Hub : Genes

Mllt6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	isoform ratio	XM_039087725.1	0.05	0.06	9.9e-03	0.02	0.02	0.02	0.02	4.6e-03	4.5e-03	4.1e-03	4.3e-03
2	Brain	intron excision ratio	chr10_82666271_82667041	0.03	0.02	5.7e-03	0.02	0.01	0	0.01	9.4e-03	1.9e-02	1.1e-01	1.5e-02
3	RMTg	gene expression	Mllt6	0.15	0.1	1.3e-03	0.06	0.06	0.02	0.07	1.0e-02	8.0e-03	9.5e-02	5.6e-03
4	Adipose	mRNA stability	Mllt6	0.03	0.03	3.8e-05	0.03	0.03	0.03	0.03	2.9e-04	1.5e-04	5.6e-04	2.2e-04
5	Liver	gene expression	Mllt6	0.09	0.05	4.4e-16	0.13	0.12	0.12	0.13	1.3e-14	1.4e-13	9.7e-14	2.0e-14
6	Brain	gene expression	Mllt6	0.05	0.04	2.6e-05	0.04	0.04	0.04	0.04	9.2e-05	1.8e-04	9.3e-05	1.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.9	3.2	4.0	-2.0	-1.9	-1.7	-1.8	1.6	1.6
Area under the delay curve	0.8	0.9	1.0	-0.9	-0.9	-1.0	-0.9	1.0	1.0
BMI with tail	1.3	4.3	5.5	2.3	2.3	2.1	1.8	-2.1	-1.7
BMI without tail	0.1	0.3	0.5	0.5	0.7	0.5	0.5	-0.5	-0.5
Body weight	5.9	24.6	27.9	5.2	5.3	5.0	4.9	-4.8	-4.5
Weight adjusted by age	0.2	0.2	0.3	0.4	0.5	0.4	0.5	-0.4	-0.6
Bone surface	0.0	0.1	0.1	0.1	0.1	0.3	0.2	-0.3	-0.3
Bone volume	0.0	0.1	0.1	-0.4	-0.3	-0.1	-0.2	0.0	0.1
Breakpoint value in progressive ratio session	1.0	1.1	1.6	1.2	1.2	1.0	1.2	-0.8	-0.8
Number of licking bursts	0.5	0.6	0.8	-0.9	-0.9	-0.7	-0.8	0.7	0.7
Context. condit. distance diff. score	0.4	0.5	0.7	0.7	0.6	0.7	0.6	-0.6	-0.8
Locomotion velocity, session 1	0.9	1.0	1.2	1.0	1.1	1.1	1.0	-1.1	-0.8
Locomotion distance, session 1	4.1	5.2	5.7	2.4	2.4	2.3	2.4	-2.3	-1.9
Locomotion velocity, session 2	0.8	1.0	1.1	0.9	1.0	1.0	1.1	-1.0	-1.0
Locomotion distance, session 2	1.3	1.8	2.1	1.3	1.3	1.4	1.4	-1.4	-1.2
Locomotion velocity, session 3	0.1	0.2	0.2	0.5	0.4	0.4	0.4	-0.4	-0.1
Locomotion distance, session 3	0.7	0.7	1.0	0.8	0.7	0.9	1.0	-0.9	-0.9
Stereotopy head waving bouts, day 3	4.0	4.7	5.1	-2.1	-2.1	-2.2	-2.3	2.2	2.1
Stereotopy head waving duration, day 3	0.7	0.9	1.0	-0.8	-0.9	-0.9	-1.0	1.0	1.0
Locomotion velocity, session 7	0.6	0.7	1.0	1.0	1.0	0.7	0.9	-0.7	-0.5
Locomotion distance, session 7	0.1	0.1	0.2	0.4	0.3	0.2	0.4	-0.1	-0.3
Stereotopy head waving bouts, day 7	0.9	1.1	1.4	-1.2	-1.2	-1.0	-1.1	0.9	0.8
Stereotopy head waving duration, day 7	0.2	0.2	0.4	-0.6	-0.7	-0.4	-0.5	0.3	0.3
Locomotion velocity, session 8	6.8	8.1	8.6	2.9	2.9	2.9	2.8	-2.8	-2.7
Locomotion distance, session 8	1.8	2.7	2.9	1.6	1.6	1.7	1.7	-1.7	-1.7
Degree of sensitization distance	0.2	0.2	0.3	0.5	0.5	0.3	0.4	-0.3	-0.3
Degree of sensitization stereotypy	1.6	1.8	2.3	-1.5	-1.5	-1.3	-1.4	1.2	1.1
Conditioned locomotion	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.4	0.4	0.4
Cocaine response after cond. corrected	2.3	2.6	3.8	-1.8	-1.9	-1.4	-1.6	1.3	1.4
Cocaine response after cond. not corrected	3.8	4.2	5.9	-2.3	-2.4	-1.9	-2.0	1.8	1.8
Cocaine response before conditioning	1.0	1.3	1.7	-1.1	-1.1	-1.3	-1.1	1.3	0.9
Saline control response	0.5	0.6	1.1	-0.6	-0.7	-0.8	-0.7	0.8	1.1
Bone: connectivity density	2.6	4.1	4.6	-2.2	-2.1	-2.0	-2.0	1.9	1.9
Bone: cortical apparent density	5.1	6.8	8.8	-2.9	-3.0	-2.5	-2.5	2.4	2.1
Bone: cortical area	0.1	0.2	0.3	-0.6	-0.5	-0.4	-0.4	0.3	0.2
Bone: cortical porosity	0.8	0.9	1.0	-0.9	-0.9	-0.9	-1.0	0.9	1.0
Bone: cortical porosity	1.1	1.2	1.6	-1.0	-1.0	-1.1	-1.1	1.1	1.3
Bone: cortical thickness	1.3	2.1	3.3	-1.8	-1.7	-1.4	-1.4	1.2	1.0
Bone: cortical thickness	4.9	5.7	6.5	-2.6	-2.5	-2.4	-2.3	2.4	2.1
Bone: cortical tissue density	5.1	6.8	8.8	-2.9	-3.0	-2.5	-2.5	2.4	2.1
Condit. Reinf. active minus inactive responses	0.4	0.4	0.5	-0.6	-0.6	-0.7	-0.7	0.7	0.5
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.2	-0.8	-0.7	-1.0	-1.0	1.1	0.9
Condit. Reinf. active responses	0.6	0.7	0.9	-0.9	-0.9	-0.9	-0.9	0.8	0.7
Condit. Reinf. inactive responses	0.5	0.6	0.8	-0.9	-0.9	-0.7	-0.8	0.6	0.8
Incentive salience index mean	1.2	1.5	1.6	-1.2	-1.1	-1.3	-1.2	1.2	1.1
Condit. Reinf. lever presses	0.9	1.3	1.4	-1.2	-1.1	-1.1	-1.1	1.1	1.2
Condit. Reinf. active minus inactive responses	0.7	0.8	1.4	-0.8	-0.8	-0.9	-0.8	0.9	1.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	-0.5	-0.5	-0.4	-0.5	0.4	0.7
Condit. Reinf. active responses	1.2	1.6	2.2	-1.1	-1.1	-1.3	-1.2	1.4	1.5
Condit. Reinf. inactive responses	2.5	3.1	3.7	-1.6	-1.6	-1.9	-1.7	1.9	1.9
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.2	-0.1	-0.3	-0.2	0.3	0.4
Condit. Reinf. lever reinforcers received	1.1	1.5	2.1	-1.1	-1.0	-1.3	-1.2	1.3	1.5
Conditioned reinforcement - actives	2.0	2.0	2.7	-1.1	-1.2	-1.4	-1.4	1.5	1.6
Conditioned reinforcement - inactives	1.6	1.8	2.9	-0.9	-1.0	-1.4	-1.3	1.5	1.7
Conditioned locomotion	1.6	2.0	2.9	-1.2	-1.2	-1.4	-1.4	1.5	1.7
Patch foraging indifference point 0 sec	1.5	2.4	3.2	-1.5	-1.5	-1.5	-1.5	1.5	1.8
Patch foraging indifference point AUC	0.2	0.2	0.6	0.0	0.0	0.5	0.3	-0.6	-0.8
Delay disc. indifference point, 0s delay	1.1	1.2	1.4	-1.2	-1.1	-1.1	-1.1	1.0	1.2
Delay disc. indifference point, 16s delay	0.7	0.7	0.9	-0.9	-0.9	-0.8	-0.8	0.8	0.7
Delay disc. indifference point, 2s delay	2.4	2.6	3.0	-1.7	-1.6	-1.6	-1.5	1.6	1.7
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.1	0.1	-0.3
Delay disc. indifference point, 4s delay	0.4	0.4	0.7	-0.8	-0.6	-0.7	-0.4	0.7	0.6
Delay disc. indifference point, 8s delay	0.8	0.9	1.2	-0.7	-0.8	-1.0	-0.9	1.1	1.0
Indifference point function ln k	0.0	0.0	0.1	-0.0	0.0	-0.2	-0.1	0.3	0.3
Indifference point function log k	0.0	0.0	0.1	-0.0	0.0	-0.2	-0.1	0.3	0.3
Patch foraging total patch changes 0 sec	0.9	1.5	2.1	-1.2	-1.2	-1.2	-1.2	1.2	1.5
Patch foraging total patch changes 12 sec	4.5	5.8	6.5	-2.5	-2.6	-2.3	-2.4	2.2	2.5
Patch foraging total patch changes 18 sec	0.4	0.5	0.8	-0.9	-0.8	-0.5	-0.7	0.4	0.7
Patch foraging total patch changes 24 sec	1.7	2.0	3.0	-1.7	-1.6	-1.3	-1.5	1.1	1.2
Patch foraging total patch changes 6 sec	1.2	1.8	2.4	-1.5	-1.6	-1.2	-1.4	1.1	1.3
Patch foraging time to switch 0 sec	0.1	0.1	0.3	-0.2	-0.3	-0.3	-0.3	0.3	0.6
Patch foraging water rate 0 sec	0.1	0.1	0.3	0.2	0.2	0.2	0.2	-0.2	-0.6
Patch foraging water rate 12 sec	0.4	0.6	1.0	0.7	0.9	0.7	0.8	-0.8	-1.0
Patch foraging water rate 18 sec	0.5	0.6	1.0	-0.7	-0.5	-1.0	-0.7	1.0	0.7
Patch foraging water rate 24 sec	0.3	0.4	0.5	-0.5	-0.6	-0.7	-0.7	0.7	0.6
Patch foraging water rate 6 sec	0.7	1.0	1.3	-1.1	-1.1	-1.1	-1.0	1.1	0.6
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.0	0.2	0.0	-0.0	-0.1	-0.3
Distance traveled before self-admin	0.2	0.2	0.7	0.7	0.9	0.2	0.4	-0.1	0.1
Distance traveled after self-admin	1.5	1.7	2.5	1.6	1.5	1.2	1.2	-1.1	-1.3
Extensor digitorum longus weight	8.1	32.0	33.0	5.7	5.7	5.7	5.7	-5.7	-5.4
Bone: elastic displacement	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	0.1	0.3
Bone: elastic work	0.0	0.0	0.0	-0.0	0.0	0.1	0.1	-0.2	-0.1
Bone: endosteal estimation	2.0	4.3	5.2	2.3	2.3	2.0	2.1	-1.9	-1.9
Bone: endosteal perimeter	1.8	3.8	5.0	2.2	2.2	1.9	1.9	-1.8	-1.7
Epididymis fat weight	0.3	0.6	0.9	1.0	0.9	0.7	0.7	-0.5	-0.8
Delta time in closed arm before/after self-admin	3.6	3.5	4.5	2.0	2.1	1.8	1.8	-1.8	-1.7
Delta time in open arm before/after self-admin	0.1	0.1	0.1	-0.3	-0.3	-0.1	-0.2	0.1	0.1
Diff in mean of infusions in LGA sessions	0.1	0.2	0.5	0.7	0.6	0.2	0.2	0.0	0.0
Delay discount exponential model param	0.4	0.4	0.5	0.7	0.6	0.7	0.6	-0.7	-0.7
Extinction: sum of active levers before priming	0.9	0.9	1.5	1.0	1.0	0.7	0.8	-0.6	-1.2
Active lever presses in extinction session 6	0.2	0.2	0.3	-0.4	-0.3	-0.5	-0.5	0.6	-0.2
Bone: final force	1.2	1.9	2.2	-1.5	-1.5	-1.3	-1.4	1.3	1.2
Bone: final moment	1.0	1.6	1.8	-1.3	-1.3	-1.2	-1.3	1.2	1.2
Food consumed during 24 hour testing period	1.2	1.4	1.8	1.0	1.1	1.3	1.2	-1.3	-1.2
Glucose	0.6	0.8	1.1	-1.0	-1.0	-0.9	-0.9	0.9	0.8
Heart weight	3.0	4.3	5.5	2.3	2.3	2.0	1.9	-1.9	-1.9
Delay discount hyperbolic model param	0.6	0.7	0.8	0.8	0.8	0.9	0.7	-0.9	-0.9
Intermittent access intake day 1-15 change	0.2	0.2	0.3	-0.3	-0.3	-0.5	-0.5	0.6	0.2
Intermittent access intake escalation	0.1	0.1	0.2	-0.1	-0.1	-0.3	-0.3	0.4	0.3
Intermittent access intake escalation 2	0.2	0.2	0.3	0.4	0.5	0.3	0.3	-0.4	-0.6
Intermitt. access day 1 inactive lever presses	1.0	1.1	1.6	-0.7	-0.9	-1.0	-1.0	1.1	1.3
Intermitt. access day 15 inactive lever presses	2.7	2.9	3.5	-1.7	-1.4	-1.7	-1.8	1.7	1.9
Intermitt. access escalation Index	0.7	0.6	1.0	0.7	0.7	0.9	0.8	-1.0	-0.7
Intermittent access day 1 total infusions	0.1	0.2	0.3	-0.3	-0.4	-0.5	-0.4	0.5	0.3
Intermittent access day 15 total infusions	0.3	0.3	0.6	-0.3	-0.4	-0.7	-0.6	0.8	0.5
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.5	-0.4	-0.6	-0.6	-0.7	0.7	0.5
Intermittent access total infusions	0.1	0.1	0.2	-0.0	-0.2	-0.3	-0.2	0.4	0.2
Intermittent access day 1 locomotion	0.4	0.4	0.6	-0.5	-0.5	-0.7	-0.6	0.8	0.7
Intermittent access day 15 total locomotion	0.6	0.6	1.0	-0.7	-0.6	-1.0	-0.8	1.0	0.5
Intermittent access total locomotion	0.8	0.9	1.2	-0.8	-0.7	-1.0	-1.0	1.1	1.0
Intermittent access standard deviation	0.2	0.2	0.3	-0.3	-0.3	-0.5	-0.5	0.5	0.3
Left kidney weight	2.8	7.9	8.8	2.7	2.8	2.8	2.8	-2.8	-3.0
Right kidney weight	0.7	1.8	2.6	1.2	1.2	1.4	1.3	-1.4	-1.6
Cocaine induced anxiety	2.2	2.5	2.7	1.6	1.6	1.6	1.5	-1.6	-1.7
Post-drug Anxiety	0.0	0.0	0.0	0.2	0.1	0.2	0.1	-0.2	-0.1
Baseline Anxiety	3.4	3.6	5.0	-1.8	-1.8	-1.8	-1.9	1.8	2.2
Tail length	1.4	4.2	5.8	1.8	2.1	1.9	2.4	-1.9	-2.2
Length with tail	5.3	19.5	22.3	4.3	4.4	4.3	4.7	-4.3	-4.4
Length without tail	4.6	10.0	11.1	3.3	3.2	3.2	3.2	-3.0	-3.0
Times rat made contact with spout	0.8	0.9	1.4	-1.2	-1.1	-0.9	-0.9	0.8	0.8
Lifetime Intake	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.2	0.4	0.1
Liver weight, left	0.1	0.2	0.4	0.5	0.6	0.3	0.4	-0.3	-0.6
Liver weight, right	0.0	0.0	0.0	-0.1	-0.0	-0.2	0.1	0.2	-0.2
Locomotor activity	0.6	1.0	1.2	-1.0	-0.9	-1.0	-1.1	1.0	1.0
Locomotor testing distance	3.4	5.6	6.4	-2.1	-2.1	-2.5	-2.5	2.5	2.5
Locomotor testing rearing	5.4	8.3	9.3	-2.9	-2.9	-3.1	-3.0	3.0	2.5
Locomotion in novel chamber	3.3	4.1	6.9	-2.6	-2.0	-2.1	-2.0	1.8	1.5
Locomotion in novel chamber post-restriction	0.6	0.8	1.0	-1.0	-1.0	-0.7	-1.0	0.6	1.0
Fecal boli incidents, locomotor time 1	0.3	0.3	0.4	0.5	0.6	0.6	0.4	-0.7	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.4	0.5	0.1
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.0	-0.9	-1.0	-1.0	-1.0	1.0	0.9
Bouts of movement, locomotor time 1	0.3	0.3	0.7	0.8	0.5	0.5	0.6	-0.4	-0.3
Total resting periods, locomotor time 1	0.4	0.5	1.0	1.0	0.7	0.7	0.7	-0.6	-0.4
Rest time, locomotor task time 1	0.0	0.0	0.2	0.1	0.0	0.1	-0.0	-0.1	0.4
Distance moved, locomotor task time 1	0.3	0.3	0.5	-0.6	-0.6	-0.7	-0.4	0.7	0.3
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.1	0.3	-0.2	0.1	0.2	-0.3
Time >=10cm from walls, locomotor time 2	1.9	2.0	2.3	-1.4	-1.2	-1.5	-1.4	1.5	1.4
Bouts of movement, locomotor time 2	0.1	0.2	0.3	-0.0	-0.0	-0.5	-0.4	0.6	0.5
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.2	0.2	-0.3	-0.2	0.4	0.4
Rest time, locomotor task time 2	1.2	1.3	2.4	1.3	1.5	1.1	1.0	-1.0	-0.8
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.2	-0.3	-0.0	0.1	0.0	-0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.0	0.1	0.1	-0.1	0.2	0.1	-0.1
Light reinforcement 1	2.2	4.0	4.8	-1.9	-1.9	-1.9	-2.0	2.0	2.2
Light reinforcement 2	0.7	0.9	1.1	-1.0	-1.1	-0.9	-1.0	0.9	1.0
Bone: marrow area	1.9	4.1	4.9	2.2	2.2	2.0	2.0	-1.9	-1.9
Bone: maximum diameter	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.1	-0.0	-0.0
Bone: maximum force	0.0	0.1	0.1	-0.3	-0.3	-0.2	-0.3	0.2	-0.0
Bone: maximum moment	0.0	0.0	0.0	-0.2	-0.2	-0.1	-0.1	0.1	-0.1
Mean time between licks in bursts	1.2	1.7	2.0	1.4	1.4	1.3	1.3	-1.3	-1.1
Mean num. licks in bursts	0.0	0.0	0.0	-0.0	-0.0	-0.1	-0.0	0.1	0.1
Cd content in liver	0.1	0.2	0.3	-0.3	-0.3	-0.5	-0.4	0.5	0.4
Co content in liver	1.4	1.6	1.8	1.2	1.2	1.3	1.3	-1.3	-1.3
Cu content in liver	1.0	1.2	1.3	1.1	1.0	1.1	1.1	-1.1	-1.0
Fe content in liver	1.6	1.9	2.2	1.4	1.4	1.4	1.5	-1.4	-1.4
K content in liver	0.2	0.2	0.4	-0.6	-0.6	-0.4	-0.4	0.3	0.3
Mg content in liver	0.2	0.2	0.4	-0.6	-0.6	-0.4	-0.4	0.3	0.4
Mn content in liver	0.4	0.5	0.7	-0.8	-0.8	-0.7	-0.7	0.6	0.5
Na content in liver	0.2	0.3	0.4	-0.6	-0.6	-0.4	-0.5	0.3	0.6
Rb content in liver	1.2	1.5	2.2	-1.1	-1.1	-1.2	-1.2	1.2	1.5
Se content in liver	2.1	2.6	3.3	-1.8	-1.8	-1.6	-1.6	1.5	1.3
Sr content in liver	0.2	0.2	0.3	0.4	0.4	0.4	0.5	-0.4	-0.5
Zn content in liver	1.9	2.1	3.0	-1.3	-1.3	-1.4	-1.4	1.4	1.7
Bone: minimum diameter	0.5	1.0	1.3	1.0	1.0	0.9	0.9	-0.9	-1.1
Time in familiar zone, hab. session 1	0.6	0.5	0.8	-0.6	-0.6	-0.9	-0.8	0.9	0.6
Time in novel zone, hab. session 1	0.8	0.8	1.0	-0.9	-1.0	-0.7	-0.9	0.7	1.0
Total zone transitions, hab. session 1	2.5	3.5	4.0	1.8	1.8	1.9	2.0	-1.9	-1.8
Total locomotion distance, hab. session 1	0.0	0.0	0.1	0.2	0.2	0.2	0.3	-0.2	-0.0
Locomotion velocity, hab. session 1	0.6	0.9	1.1	1.0	1.0	0.9	1.0	-0.9	-0.7
Time in familiar zone, hab. session 2	0.5	0.5	0.7	-0.6	-0.6	-0.8	-0.8	0.8	0.8
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.3	-0.2	-0.2	-0.1	0.1	0.2
Total zone transitions, hab. session 2	0.7	0.8	1.0	1.0	1.0	0.9	0.9	-0.9	-0.8
Total locomotion distance, hab. session 2	0.1	0.1	0.3	0.5	0.5	0.2	0.3	-0.2	-0.0
Locomotion velocity, hab. session 2	0.2	0.3	0.6	0.7	0.8	0.5	0.5	-0.4	-0.3
Novel to familiar place preference ratio	1.7	1.7	2.4	1.2	1.2	1.3	1.3	-1.3	-1.6
Novelty place preference	1.0	1.0	1.6	0.9	0.9	0.9	1.0	-0.9	-1.3
Time in novel zone, NPP test	0.3	0.3	0.6	0.4	0.4	0.4	0.5	-0.5	-0.8
Total zone transitions, NPP test	0.4	0.5	0.7	0.7	0.7	0.8	0.8	-0.7	-0.6
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0	-0.0	0.2
Locomotion velocity, NPP test	0.3	0.4	0.5	0.6	0.7	0.7	0.7	-0.7	-0.4
Intraocular pressure	1.3	1.8	2.2	1.4	1.4	1.2	1.3	-1.1	-1.5
Delta distance traveled before/after self-admin	1.0	1.1	1.6	1.1	1.0	1.1	0.9	-1.0	-1.3
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	0.6	0.3	0.5	0.4	-0.5	-0.6
Parametrial fat weight	0.7	1.5	2.4	-0.8	-1.0	-1.3	-1.2	1.4	1.5
Pavlov. Cond. lever latency	2.9	3.7	4.1	1.9	1.9	1.9	1.9	-1.9	-2.0
Pavlov. Cond. magazine entry latency	10.2	13.2	14.0	-3.7	-3.7	-3.7	-3.6	3.6	3.4
Pavlov. Cond. change in total contacts	7.4	8.0	9.4	-3.1	-3.0	-2.9	-2.8	2.8	2.4
Pavlov. Cond. index score	8.6	10.9	11.6	-3.4	-3.3	-3.3	-3.3	3.3	3.2
Pavlov. Cond. latency score	6.7	8.5	9.2	-3.0	-3.0	-2.9	-2.9	2.9	2.8
Pavlov. Cond. lever contacts	2.6	3.0	3.2	-1.8	-1.7	-1.8	-1.7	1.7	1.8
Pavlov. Cond. magazine entry number	12.8	16.0	17.6	4.2	4.2	4.0	4.0	-3.9	-3.7
Pavlov. Cond. intertrial magazine entries	1.6	1.9	2.0	1.4	1.4	1.4	1.4	-1.4	-1.3
Pavlov. Cond. lever-magazine prob. diff.	9.8	12.2	12.9	-3.6	-3.5	-3.5	-3.5	3.5	3.3
Pavlov. Cond. response bias	9.7	11.8	12.5	-3.5	-3.5	-3.5	-3.4	3.4	3.3
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.5	0.4	0.5	0.5	-0.5	-0.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.1	0.2	0.2	0.3	-0.2	-0.2
Pavlov. Cond. change in total contacts	0.5	0.6	0.9	-0.7	-0.6	-0.8	-0.8	0.8	1.0
Pavlov. Cond. index score	0.1	0.2	0.2	-0.5	-0.4	-0.4	-0.4	0.4	0.4
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.4	-0.3	-0.3	-0.3	0.3	0.3
Pavlov. Cond. lever contacts	0.8	1.1	1.3	-1.0	-0.9	-1.1	-1.0	1.1	1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.4	0.3	0.3	0.2	-0.3	-0.4
Pavlov. Cond. intertrial magazine entries	1.4	1.8	1.9	1.4	1.3	1.4	1.4	-1.4	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	-0.3	-0.2	-0.3	-0.2	0.2	0.3
Pavlov. Cond. response bias	0.9	1.3	1.5	-1.1	-1.0	-1.1	-1.1	1.1	1.2
Time in closed arm before self-admin	1.6	1.8	3.3	-1.2	-1.4	-1.1	-1.3	1.2	1.8
Time in closed arm after self-admin	0.6	0.6	0.7	0.8	0.9	0.8	0.8	-0.9	-0.3
Time in open arm before self-admin	3.3	3.6	5.1	2.0	2.2	1.7	1.8	-1.7	-1.8
Time in open arm after self-admin	0.6	0.6	1.0	0.8	1.0	0.7	0.7	-0.7	-0.8
Bone: periosteal estimation	0.2	0.4	0.5	0.6	0.7	0.6	0.6	-0.6	-0.7
Bone: periosteal perimeter	0.7	1.2	1.5	1.1	1.2	1.0	1.0	-1.0	-1.0
Bone: post-yield work	0.9	1.3	1.4	1.2	1.2	1.1	1.1	-1.1	-1.2
Progressive ratio test 1 active lever presses	1.3	1.4	1.8	-1.2	-1.3	-1.1	-1.1	1.1	1.1
Progressive ratio test 1 breakpoint	1.4	1.5	2.0	-1.2	-1.4	-1.2	-1.1	1.2	1.2
Progressive ratio test 1 inactive lever presses	1.2	1.3	2.1	-0.9	-1.0	-1.2	-1.1	1.2	1.4
Progressive ratio test 2 active lever presses	1.1	1.2	1.4	-1.0	-1.0	-1.2	-1.1	1.2	1.0
Progressive ratio test 2 breakpoint	1.0	1.1	1.3	-1.0	-1.0	-1.1	-1.1	1.2	0.9
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.1	0.1	-0.3	-0.1	0.2	-0.0
Incentive Sensitization - Responses	0.9	0.9	1.1	-1.0	-0.8	-1.0	-1.0	1.0	0.9
Incentive Sensitization - Breakpoint	0.8	0.8	1.0	-1.0	-0.8	-1.0	-1.0	0.9	0.8
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.6	-0.6	-0.6	-0.7	-0.6	0.8	-0.1
Progressive ratio	0.0	0.0	0.2	-0.1	0.0	0.0	0.0	-0.0	0.4
Food seeking constrained by brief footshock	0.3	0.4	0.8	-0.6	-0.9	-0.5	-0.6	0.5	0.5
Seeking ratio, punishment vs. effort	0.2	0.2	0.4	-0.5	-0.7	-0.5	-0.5	0.5	-0.1
Retroperitoneal fat weight	0.1	0.2	0.5	0.7	0.6	0.3	0.5	-0.2	-0.2
Reaction time number correct	0.7	1.0	1.1	1.0	1.0	1.1	1.1	-1.1	-0.7
Reaction time mean minus median	0.0	0.0	0.1	0.2	0.2	0.1	0.1	-0.1	0.3
Reaction time mean minus median AUC	0.4	0.6	1.3	-0.6	-0.6	-0.7	-0.7	0.7	1.1
Reaction time num false alarms	0.8	1.1	1.5	-1.0	-1.0	-1.2	-1.0	1.2	0.9
Reaction time num false alarms AUC	0.6	0.9	1.2	-0.9	-0.9	-1.0	-0.9	1.1	0.8
Reaction time trials correct on left	0.7	1.0	1.1	1.0	1.0	1.1	1.1	-1.1	-0.7
Reaction time trials on left	0.7	0.9	1.1	1.0	1.0	1.0	1.0	-1.0	-0.6
Reaction time mean	0.0	0.0	0.1	-0.2	-0.1	-0.0	-0.1	-0.0	0.3
Reaction time mean AUC	0.0	0.0	0.1	-0.1	0.1	-0.0	-0.1	-0.0	0.3
Median of all reaction times	0.2	0.3	0.5	-0.7	-0.5	-0.5	-0.6	0.4	0.6
Reaction time omissions	0.8	1.0	1.2	-1.0	-1.1	-1.0	-0.9	1.0	1.1
Reaction time false alarm rate	1.3	1.8	2.3	-1.3	-1.3	-1.5	-1.3	1.5	1.1
Reaction time premature initiation rate	0.4	0.5	1.0	-0.6	-0.7	-0.5	-0.7	0.5	1.0
Reaction time premature initiations	0.0	0.1	0.1	0.2	0.1	0.3	0.1	-0.3	0.3
Std. dev. reaction times	0.0	0.1	0.2	-0.2	-0.2	-0.1	-0.1	0.1	0.5
Reaction time trials completed	0.7	0.9	1.1	1.0	1.0	1.0	1.0	-1.0	-0.6
Reaction time trials AUC	0.5	0.7	0.9	0.9	0.9	0.9	0.9	-0.9	-0.5
Run reversals in cocaine runway, females	2.4	2.3	2.9	1.6	1.7	1.4	1.5	-1.3	-1.6
Run reversals in cocaine runway, males	0.5	0.5	0.7	-0.7	-0.2	-0.8	-0.8	0.7	0.8
Latency to leave start box in cocaine runway	3.2	3.4	3.9	1.8	2.0	1.9	1.8	-1.9	-1.7
Latency to leave start box in cocaine runway, F	2.6	2.9	3.6	1.7	1.7	1.9	1.6	-1.9	-1.3
Latency to leave start box in cocaine runway, M	0.5	0.5	1.2	0.6	0.8	0.6	0.6	-0.6	-1.1
Std. dev. time between licks in bursts	0.3	0.3	0.4	0.5	0.6	0.6	0.5	-0.6	-0.4
Total sessions with >9 infusions	0.9	1.0	1.2	-0.9	-1.1	-1.0	-1.0	1.1	0.9
Short access day 1 total inactive lever presses	1.7	1.9	2.6	-1.1	-1.2	-1.5	-1.3	1.6	1.5
Short access day 10 total inactive lever presses	0.4	0.4	0.7	0.8	0.8	0.7	0.7	-0.6	-0.2
Short access day 1 total infusions	0.2	0.2	0.3	-0.2	-0.3	-0.5	-0.5	0.5	0.3
Short access day 10 total infusions	0.1	0.2	0.2	-0.4	-0.5	-0.4	-0.4	0.5	-0.0
Short access total infusions	0.0	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1	-0.1
Short access day 1 locomotion	2.2	2.4	2.6	-1.6	-1.6	-1.5	-1.6	1.5	1.5
Short access day 10 total locomotion	1.9	2.2	2.3	-1.5	-1.5	-1.5	-1.5	1.5	1.4
Short access total locomotion	0.6	0.6	0.8	-0.6	-0.8	-0.8	-0.8	0.9	0.9
One hour access (0.3 mA shock)	0.1	0.1	0.3	-0.0	-0.2	-0.4	-0.3	0.5	0.3
Compulsive drug intake	0.0	0.0	0.1	0.1	-0.1	0.1	0.2	-0.1	0.2
One hour access (shock baseline)	0.2	0.3	0.5	-0.2	-0.2	-0.6	-0.6	0.7	0.6
Social response proportion	0.1	0.1	0.3	-0.0	-0.0	-0.2	-0.0	0.3	0.6
Social responses	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.3	0.4	0.5
Social time	0.0	0.0	0.0	0.1	0.0	0.0	-0.0	0.0	0.1
Soleus weight	0.5	1.5	1.7	-1.3	-1.2	-1.2	-1.2	1.1	1.3
Bone: stiffness	0.0	0.1	0.1	-0.3	-0.3	-0.2	-0.3	0.2	0.0
Tibialis anterior weight	1.4	4.7	4.9	2.1	2.2	2.2	2.2	-2.2	-2.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.4	0.6	0.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.5	-0.4	-0.2	-0.3	0.2	0.1
Time to tail flick, test, before self-admin	0.6	0.6	1.0	0.9	0.7	0.7	0.7	-0.6	-1.0
Time to tail flick, test, after self-admin	0.1	0.1	0.4	-0.3	-0.3	-0.0	-0.1	-0.1	-0.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	-0.6	-0.7	-0.5	-0.6	0.4	0.4
Delta time to tail flick, test, before/after SA	1.4	1.3	2.0	-1.4	-1.2	-1.1	-1.0	1.0	1.0
Tibia length	0.8	2.3	2.8	1.4	1.4	1.6	1.5	-1.6	-1.7
Ambulatory time before self-admin	0.5	0.5	1.2	0.9	1.1	0.5	0.6	-0.4	-0.3
Ambulatory time after self-admin	3.0	3.3	3.9	2.0	1.9	1.8	1.7	-1.7	-1.9
Bone: tissue strength	0.4	0.4	0.6	0.5	0.4	0.7	0.6	-0.8	-0.8
Total heroin consumption	0.2	0.2	0.4	-0.7	-0.4	-0.5	-0.5	0.5	0.0
Bone: trabecular number	4.7	7.4	8.3	-2.9	-2.8	-2.7	-2.8	2.6	2.5
Bone: trabecular spacing	0.7	0.9	1.3	1.1	1.0	1.0	0.9	-0.9	-0.8
Bone: trabecular thickness	0.0	0.0	0.1	-0.3	-0.1	0.0	-0.1	-0.1	0.0
Bone: trabecular tissue density	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.1	0.2
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.0	-0.1	0.2
Number of responses in last shaping day	0.1	0.1	0.3	0.2	0.1	0.2	0.2	-0.3	-0.5