Hub : Genes

Mlip

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Mlip 0.07 0.04 3.1e-06 0.04 0.03 0.04 0.03 9.5e-07 3.1e-05 4.4e-06 5.4e-06
2 BLA gene expression Mlip 0.15 0.1 6.4e-03 0.04 0.05 0.05 0.05 2.0e-03 1.7e-03 1.1e-03 1.3e-03
3 NAcc alternative TSS XM_063266133.1 0.03 0.02 9.1e-03 0.01 0.01 0.01 0.01 6.4e-03 1.4e-02 2.6e-02 9.2e-03
4 NAcc intron excision ratio chr8_86900503_86953094 0.02 0.01 7.1e-03 0.01 0.01 0.01 0.01 1.0e-02 2.3e-03 3.7e-02 1.5e-02
5 IC gene expression Mlip 0.1 0.07 2.1e-03 0.01 0.03 0.01 0.01 9.3e-02 1.8e-02 1.3e-01 8.3e-02
6 PL gene expression Mlip 0.05 0.04 6.2e-03 0.03 0.02 0.04 0.03 1.9e-04 2.9e-03 8.8e-05 1.4e-04
7 Adipose mRNA stability Mlip 0.02 0.01 8.7e-03 0 0.01 -0 -0 9.4e-02 3.0e-02 7.6e-01 3.9e-01
8 NAcc mRNA stability Mlip 0.03 0.02 4.7e-04 0.02 0.01 0.02 0.01 4.1e-04 2.0e-03 9.8e-04 3.1e-03
9 IC intron excision ratio chr8_86908366_86908656 0.11 0.07 1.6e-04 0.06 0.1 0.07 0.07 2.3e-03 4.7e-05 7.2e-04 5.4e-04
10 Brain isoform ratio XM_039082523.1 0.03 0.02 8.3e-03 0 0 -0 -0 1.2e-01 1.6e-01 7.4e-01 5.5e-01
11 NAcc intron excision ratio chr8_86908366_86908656 0.02 0.01 1.5e-03 0.01 0.02 0.01 0.01 1.7e-03 1.6e-03 4.0e-03 1.9e-03
12 PL intron excision ratio chr8_86908366_86908656 0.03 0.02 2.4e-04 0.03 0.02 0.02 0.02 4.7e-04 5.7e-03 2.9e-03 4.0e-03
13 IC intron excision ratio chr8_86890338_86900459 0.24 0.12 3.4e-06 0.12 0.13 0.08 0.12 7.9e-06 5.5e-06 3.3e-04 9.5e-06
14 IC intron excision ratio chr8_86900503_86953094 0.12 0.06 6.7e-05 0.1 0.09 0.05 0.08 4.4e-05 2.0e-04 3.5e-03 2.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.91.76.52.32.61.0-1.4-1.42.0-1.00.70.8-0.6-0.2-0.50.10.5
Area under the delay curve0.10.20.9-0.4-0.3-0.7-0.1-0.2-1.0-0.20.20.4-0.10.4-0.0-0.80.5
BMI with tail2.58.938.96.24.74.8-2.7-2.53.3-1.60.81.2-0.6-2.30.22.30.3
BMI without tail0.84.119.24.43.22.6-2.3-2.01.6-1.41.41.1-1.4-0.90.11.20.0
Body weight1.88.127.75.34.64.1-3.0-2.93.4-2.01.51.5-1.6-1.4-1.61.50.6
Weight adjusted by age0.72.17.52.72.61.8-1.3-1.42.0-1.00.60.8-0.4-0.7-1.00.60.6
Bone surface2.03.815.33.53.92.6-1.5-1.53.2-0.90.10.5-0.1-1.4-0.51.20.2
Bone volume1.73.412.23.33.52.0-1.9-1.92.8-1.30.91.1-0.8-0.6-0.90.50.6
Breakpoint value in progressive ratio session0.40.81.51.11.20.60.20.41.00.6-0.7-0.70.8-1.01.11.2-1.0
Number of licking bursts0.20.62.71.41.70.8-0.3-0.10.70.3-0.0-0.30.1-0.80.90.9-0.8
Context. condit. distance diff. score0.30.31.80.60.01.3-0.6-0.50.7-0.50.20.4-0.2-0.2-0.70.40.3
Locomotion velocity, session 10.60.71.9-0.10.2-0.3-0.9-0.7-1.1-0.71.00.8-1.40.9-0.8-0.90.5
Locomotion distance, session 10.50.71.1-0.10.1-0.1-1.0-0.9-0.6-0.91.01.0-1.00.8-0.9-1.10.9
Locomotion velocity, session 20.70.82.7-1.7-1.1-1.41.10.8-1.00.7-0.9-0.50.60.20.2-0.70.2
Locomotion distance, session 20.30.41.6-0.90.0-1.1-0.1-0.2-0.3-0.20.30.4-0.30.8-0.7-1.30.5
Locomotion velocity, session 30.40.42.40.71.50.3-0.7-0.70.9-0.40.40.4-0.6-0.1-0.2-0.20.3
Locomotion distance, session 30.20.21.3-0.70.1-1.10.10.10.20.10.30.0-0.30.5-0.1-0.6-0.1
Stereotopy head waving bouts, day 31.31.62.6-0.6-1.00.31.61.6-0.11.5-1.6-1.51.4-1.21.51.3-1.1
Stereotopy head waving duration, day 30.30.40.8-0.4-0.90.70.80.7-0.30.6-0.9-0.60.7-0.60.40.7-0.3
Locomotion velocity, session 70.91.02.10.2-0.11.10.91.00.51.1-1.1-1.21.1-1.20.51.4-1.2
Locomotion distance, session 70.20.31.4-0.8-1.20.40.60.4-0.60.4-0.6-0.40.4-0.3-0.60.2-0.2
Stereotopy head waving bouts, day 70.30.31.20.91.10.7-0.6-0.50.7-0.30.20.3-0.4-0.2-0.00.10.2
Stereotopy head waving duration, day 70.60.83.41.51.91.2-0.8-0.71.3-0.40.20.3-0.3-0.60.20.50.1
Locomotion velocity, session 80.20.20.50.60.60.5-0.6-0.70.7-0.50.20.5-0.2-0.20.0-0.10.4
Locomotion distance, session 80.10.21.0-0.30.3-0.0-0.4-0.40.3-0.30.30.4-0.40.2-1.0-0.60.5
Degree of sensitization distance0.30.31.6-0.3-1.30.8-0.0-0.1-0.9-0.2-0.10.20.10.0-0.80.10.3
Degree of sensitization stereotypy0.40.51.71.11.30.7-0.9-0.80.5-0.50.60.6-0.7-0.0-0.10.00.2
Conditioned locomotion1.72.04.1-1.5-1.9-1.61.41.8-2.01.6-0.3-1.50.20.11.10.6-2.0
Cocaine response after cond. corrected0.10.20.40.3-0.00.50.30.30.40.4-0.3-0.40.4-0.5-0.20.6-0.6
Cocaine response after cond. not corrected0.20.31.10.90.51.0-0.0-0.10.90.0-0.3-0.20.4-0.7-0.40.7-0.3
Cocaine response before conditioning0.81.04.71.62.21.0-0.6-0.81.7-0.5-0.00.3-0.1-0.6-0.20.40.5
Saline control response0.60.82.81.60.11.7-1.2-0.8-0.2-0.80.90.6-1.0-0.1-0.30.9-0.3
Bone: connectivity density0.71.26.81.92.60.4-0.6-0.62.1-0.20.10.1-0.0-0.60.20.5-0.2
Bone: cortical apparent density0.81.24.7-1.9-2.2-1.70.70.6-1.60.10.3-0.0-0.21.2-0.4-0.90.3
Bone: cortical area0.81.32.81.10.70.3-1.5-1.3-0.2-1.41.71.3-1.61.1-1.3-0.60.7
Bone: cortical porosity0.91.03.10.30.30.40.81.01.01.0-0.7-1.20.7-0.91.81.3-1.3
Bone: cortical porosity1.31.43.6-0.0-0.00.31.21.31.11.3-1.1-1.51.1-1.01.91.4-1.4
Bone: cortical thickness0.91.63.9-1.2-1.4-2.0-0.20.1-2.0-0.41.60.5-1.52.0-0.6-1.2-0.0
Bone: cortical thickness0.10.21.2-0.2-1.1-0.30.20.3-0.60.20.3-0.2-0.20.30.00.2-0.3
Bone: cortical tissue density0.71.24.8-1.9-2.2-1.60.70.6-1.50.20.2-0.1-0.11.1-0.4-0.90.3
Condit. Reinf. active minus inactive responses0.40.51.2-0.20.9-0.50.80.50.90.8-1.1-0.80.8-0.80.30.2-0.4
Condit. Reinf. active-inactive response ratio0.60.62.3-0.3-0.30.51.10.60.50.6-1.5-0.81.2-1.0-0.10.6-0.0
Condit. Reinf. active responses0.20.32.20.11.5-0.40.20.01.00.4-0.4-0.30.2-0.50.2-0.1-0.2
Condit. Reinf. inactive responses0.50.61.50.21.1-0.5-1.1-0.80.0-0.51.20.8-1.20.7-0.2-0.90.3
Incentive salience index mean0.30.32.00.21.4-0.20.3-0.01.10.3-0.7-0.30.4-0.6-0.2-0.10.2
Condit. Reinf. lever presses0.20.21.40.51.20.1-0.2-0.40.8-0.1-0.20.20.0-0.3-0.4-0.40.7
Condit. Reinf. active minus inactive responses1.62.44.41.20.21.1-2.1-2.1-0.2-2.11.82.0-1.81.1-1.5-1.01.7
Condit. Reinf. active-inactive response ratio0.50.82.71.3-0.21.6-1.2-1.1-0.3-1.10.80.9-0.60.0-0.40.30.5
Condit. Reinf. active responses2.02.95.21.30.90.7-2.3-2.30.2-2.22.12.1-2.01.2-1.7-1.31.8
Condit. Reinf. inactive responses1.92.84.70.61.0-0.4-2.0-2.00.1-1.92.22.0-2.11.6-2.0-1.81.9
Condit. Reinf. lever presses2.63.86.61.10.40.9-2.4-2.5-0.3-2.62.42.5-2.31.6-2.0-1.62.5
Condit. Reinf. lever reinforcers received2.53.56.10.90.40.3-2.4-2.3-0.2-2.42.52.4-2.41.8-1.9-1.72.0
Conditioned reinforcement - actives0.10.31.20.70.40.90.00.30.20.4-0.4-0.50.3-0.80.11.1-0.8
Conditioned reinforcement - inactives0.20.54.0-0.30.0-0.5-0.7-0.3-2.0-0.21.00.4-0.70.5-0.4-0.5-0.2
Conditioned locomotion0.10.10.4-0.1-0.50.60.30.3-0.30.2-0.5-0.20.3-0.40.50.5-0.1
Patch foraging indifference point 0 sec0.51.42.6-0.00.00.2-1.4-1.5-0.4-1.61.41.6-1.31.2-1.0-1.21.6
Patch foraging indifference point AUC0.40.92.8-0.8-0.5-0.2-0.6-1.0-0.1-1.10.61.0-0.40.9-1.7-1.41.4
Delay disc. indifference point, 0s delay0.40.51.7-1.20.1-1.3-0.2-0.4-0.2-0.20.40.5-0.40.7-0.3-1.30.6
Delay disc. indifference point, 16s delay1.52.25.2-2.1-2.3-2.21.71.6-2.01.3-0.9-1.01.00.41.1-0.6-0.5
Delay disc. indifference point, 2s delay0.60.71.61.01.30.5-1.2-1.00.6-0.80.90.8-0.80.2-1.0-0.30.3
Delay disc. indifference point, 24s delay0.40.61.1-1.0-0.7-1.01.01.0-0.30.9-0.6-0.80.6-0.10.70.0-0.7
Delay disc. indifference point, 4s delay0.80.91.90.61.10.2-1.4-1.3-0.4-1.11.11.2-1.00.5-0.2-0.90.9
Delay disc. indifference point, 8s delay0.30.61.30.30.40.1-0.9-1.0-0.6-0.90.61.0-0.50.5-0.5-1.01.2
Indifference point function ln k0.20.52.31.51.11.2-0.5-0.40.5-0.30.20.1-0.5-0.50.70.8-0.1
Indifference point function log k0.20.52.31.51.11.2-0.5-0.40.5-0.30.20.1-0.5-0.50.70.8-0.1
Patch foraging total patch changes 0 sec0.61.73.10.00.10.0-1.6-1.6-0.6-1.71.81.7-1.71.4-0.9-1.31.5
Patch foraging total patch changes 12 sec3.14.16.8-0.6-0.6-0.6-2.1-2.1-0.9-2.42.62.4-2.62.6-2.3-2.41.9
Patch foraging total patch changes 18 sec0.10.30.70.0-0.00.5-0.6-0.7-0.5-0.80.40.8-0.20.4-0.5-0.40.6
Patch foraging total patch changes 24 sec0.00.10.2-0.30.1-0.2-0.3-0.30.1-0.30.20.4-0.10.4-0.3-0.40.4
Patch foraging total patch changes 6 sec0.30.42.4-1.6-0.8-0.7-0.1-0.2-0.3-0.30.40.3-0.20.9-0.5-1.00.4
Patch foraging time to switch 0 sec1.55.89.7-1.0-0.9-0.33.03.00.43.1-3.0-3.13.0-2.22.62.3-2.7
Patch foraging water rate 0 sec1.14.37.91.81.21.3-2.8-2.8-0.3-2.72.32.7-2.31.4-1.8-1.42.3
Patch foraging water rate 12 sec1.24.89.71.31.20.5-3.1-2.9-0.2-2.72.82.9-2.81.8-2.0-1.81.9
Patch foraging water rate 18 sec0.71.53.01.20.90.6-1.7-1.5-0.4-1.51.51.4-1.60.8-1.1-0.71.0
Patch foraging water rate 24 sec0.91.32.30.30.60.3-1.3-1.3-0.9-1.41.41.4-1.51.1-1.3-1.11.1
Patch foraging water rate 6 sec0.91.43.31.81.31.0-1.7-1.5-0.3-1.21.21.3-1.20.2-0.8-0.20.7
Seeking ratio, delayed vs. immediate footshock0.20.31.00.4-0.10.4-0.5-0.7-0.7-0.70.10.7-0.10.3-0.5-0.71.0
Distance traveled before self-admin0.51.23.11.61.71.3-1.4-1.31.8-1.00.40.9-0.4-0.3-0.00.10.7
Distance traveled after self-admin0.91.66.82.61.72.0-1.0-0.81.7-0.40.00.2-0.1-1.1-0.51.3-0.2
Extensor digitorum longus weight0.83.29.03.03.02.8-1.8-1.92.5-1.30.21.0-0.3-1.2-0.80.70.6
Bone: elastic displacement0.50.71.60.60.30.4-1.3-0.90.1-1.01.30.9-1.20.7-0.9-0.30.2
Bone: elastic work1.51.93.21.30.61.1-1.8-1.70.8-1.81.61.6-1.80.9-1.7-0.61.2
Bone: endosteal estimation1.74.214.03.43.03.7-0.9-1.03.3-0.4-1.1-0.00.8-2.4-0.32.00.1
Bone: endosteal perimeter1.22.910.13.22.82.8-1.4-1.32.7-0.80.20.6-0.4-1.3-0.31.20.4
Epididymis fat weight0.20.95.6-0.3-0.5-2.40.10.5-0.90.41.0-0.2-1.01.10.5-0.4-1.3
Delta time in closed arm before/after self-admin0.10.10.3-0.3-0.6-0.40.60.40.50.2-0.1-0.30.10.10.60.1-0.0
Delta time in open arm before/after self-admin0.60.72.2-0.8-1.1-0.31.01.0-1.50.8-0.8-0.71.0-0.20.40.3-0.4
Diff in mean of infusions in LGA sessions0.40.83.81.20.71.3-0.2-0.01.90.2-0.6-0.30.6-1.10.41.0-0.5
Delay discount exponential model param0.10.20.60.1-0.00.40.40.40.70.3-0.4-0.50.2-0.40.10.8-0.5
Extinction: sum of active levers before priming0.50.81.4-0.9-0.8-0.61.21.10.41.1-1.0-0.90.9-0.51.20.4-0.7
Active lever presses in extinction session 60.30.32.20.10.50.20.30.31.50.4-0.5-0.40.4-0.40.80.5-0.4
Bone: final force0.60.92.30.40.60.1-1.1-1.10.0-1.21.31.1-1.51.0-1.0-0.90.9
Bone: final moment0.40.71.90.30.4-0.0-0.9-0.9-0.0-1.01.20.9-1.40.9-0.8-0.70.6
Food consumed during 24 hour testing period0.71.35.32.11.02.3-1.2-1.30.6-1.10.30.8-0.3-0.7-0.90.70.8
Glucose0.91.43.4-0.40.10.61.11.3-0.71.4-1.1-1.40.9-1.31.81.6-1.2
Heart weight0.30.52.61.61.40.4-0.7-0.60.7-0.30.00.50.1-0.40.20.20.2
Delay discount hyperbolic model param0.10.20.4-0.1-0.30.20.50.50.60.4-0.4-0.50.3-0.30.10.6-0.5
Intermittent access intake day 1-15 change0.10.52.4-0.7-0.5-1.60.10.2-1.50.30.40.1-0.40.60.3-0.9-0.0
Intermittent access intake escalation0.10.72.7-0.4-0.3-1.4-0.4-0.2-1.7-0.20.90.6-0.80.9-0.0-1.10.4
Intermittent access intake escalation 20.20.31.5-0.10.0-0.6-0.4-0.3-1.2-0.10.50.5-0.50.30.0-0.80.3
Intermitt. access day 1 inactive lever presses0.22.84.90.70.10.1-2.2-1.9-1.7-2.12.22.2-1.81.8-1.2-1.51.5
Intermitt. access day 15 inactive lever presses0.10.41.4-0.10.4-0.6-0.8-0.5-1.2-0.50.90.7-0.60.8-0.0-0.70.0
Intermitt. access escalation Index0.31.02.81.20.51.00.10.40.90.7-0.5-0.90.5-1.31.21.7-1.2
Intermittent access day 1 total infusions0.41.32.20.1-0.40.91.21.10.11.2-1.4-1.31.5-1.51.21.5-0.9
Intermittent access day 15 total infusions0.51.12.8-0.3-0.6-0.11.21.2-1.01.3-1.1-1.11.4-1.11.70.8-0.8
Intermittent access terminal intake (last 3 days)0.61.12.50.4-0.10.70.91.0-0.41.2-1.2-1.01.4-1.51.61.2-0.9
Intermittent access total infusions1.11.32.1-0.1-0.80.71.31.3-0.81.3-1.3-1.31.5-1.31.21.3-1.0
Intermittent access day 1 locomotion0.30.51.00.1-0.00.90.60.60.60.6-1.0-0.61.0-1.01.00.9-0.3
Intermittent access day 15 total locomotion0.20.61.8-0.7-1.2-0.51.00.9-0.90.7-0.7-0.60.9-0.21.30.1-0.2
Intermittent access total locomotion0.10.10.90.50.21.0-0.3-0.3-0.2-0.2-0.10.20.2-0.30.20.30.3
Intermittent access standard deviation0.10.31.0-0.7-0.8-1.00.60.6-0.60.6-0.2-0.40.00.20.0-0.3-0.3
Left kidney weight0.75.810.02.52.21.9-3.2-3.21.6-3.02.52.7-2.51.1-2.7-0.92.3
Right kidney weight1.17.713.93.12.71.8-3.7-3.61.4-3.33.13.1-3.11.3-3.2-1.12.4
Cocaine induced anxiety0.51.42.80.60.30.71.01.01.11.3-1.7-1.41.4-1.71.01.5-1.2
Post-drug Anxiety0.30.30.70.60.40.3-0.7-0.8-0.2-0.60.30.6-0.50.1-0.9-0.40.6
Baseline Anxiety4.47.411.70.10.2-0.8-2.9-3.0-1.7-3.23.43.4-3.33.1-3.1-3.23.0
Tail length0.31.73.6-1.2-0.2-1.9-0.7-0.6-1.0-0.81.60.7-1.91.8-1.7-1.60.5
Length with tail0.83.49.20.71.60.1-2.2-2.20.7-2.02.31.8-2.71.4-3.0-1.31.3
Length without tail0.73.88.32.42.92.5-2.3-2.42.6-1.91.21.5-1.3-0.2-2.10.01.3
Times rat made contact with spout2.22.64.70.80.10.5-2.2-1.9-0.7-2.02.12.0-2.21.5-1.8-1.31.4
Lifetime Intake0.91.11.90.1-0.60.71.21.2-0.51.2-1.2-1.31.2-1.30.91.4-1.1
Liver weight, left0.20.31.01.00.70.30.00.10.80.30.2-0.4-0.3-0.41.00.8-0.5
Liver weight, right0.00.00.10.20.1-0.0-0.1-0.1-0.2-0.10.3-0.0-0.30.1-0.10.00.1
Locomotor activity0.30.41.00.30.20.3-1.0-0.90.3-0.80.80.8-0.70.5-0.7-0.50.5
Locomotor testing distance0.30.81.61.10.60.9-1.3-1.10.9-0.91.10.8-1.10.3-0.9-0.10.4
Locomotor testing rearing0.20.81.81.30.80.9-1.3-1.00.6-0.81.20.8-1.10.1-0.70.20.4
Locomotion in novel chamber0.91.24.8-1.5-2.2-1.60.90.8-1.80.4-0.3-0.20.30.80.4-0.90.2
Locomotion in novel chamber post-restriction0.10.31.41.01.10.6-0.2-0.21.2-0.0-0.2-0.10.2-0.50.20.6-0.2
Fecal boli incidents, locomotor time 10.51.43.30.81.31.20.70.61.21.0-1.3-1.11.3-1.81.31.5-0.8
Change in fecal boli incidents, locomotor task1.41.42.7-0.4-1.4-0.3-0.8-0.9-1.5-1.30.91.3-0.81.5-1.6-1.61.5
Time >=10cm from walls, locomotor time 11.01.32.61.60.91.20.50.41.30.7-1.2-0.81.3-1.61.51.3-0.5
Bouts of movement, locomotor time 12.22.812.6-3.5-1.7-3.00.70.6-2.60.30.30.2-0.31.6-0.2-2.10.5
Total resting periods, locomotor time 12.42.711.1-3.3-1.7-2.90.50.3-2.60.00.40.4-0.51.7-0.5-2.20.7
Rest time, locomotor task time 10.81.34.2-2.0-1.5-2.01.11.0-2.00.8-0.3-0.60.10.50.4-0.6-0.4
Distance moved, locomotor task time 10.10.43.01.00.90.6-0.1-0.01.70.1-0.1-0.20.4-0.40.30.5-0.3
Vertical activity count, locomotor time 10.10.51.3-0.0-0.30.20.80.80.10.7-1.0-0.91.1-0.60.70.6-0.6
Time >=10cm from walls, locomotor time 20.30.82.7-0.0-0.70.21.01.0-0.10.9-1.1-1.01.2-0.81.60.7-0.6
Bouts of movement, locomotor time 20.41.56.8-2.6-1.3-2.30.50.6-1.70.40.2-0.0-0.11.2-0.4-1.3-0.1
Total resting periods, locomotor time 20.41.66.9-2.6-1.4-2.30.50.6-1.90.30.20.0-0.11.2-0.5-1.40.0
Rest time, locomotor task time 21.52.57.3-2.7-2.4-2.61.51.5-2.61.0-0.3-0.80.11.00.1-0.9-0.5
Distance moved, locomotor task time 20.50.72.01.01.20.5-1.1-1.01.4-0.90.90.8-0.70.4-0.4-0.40.5
Vertical activity count, locomotor time 20.30.71.81.40.91.30.10.11.30.2-0.7-0.50.7-1.00.41.1-0.5
Light reinforcement 10.00.10.3-0.10.3-0.60.30.30.60.6-0.2-0.30.2-0.40.60.1-0.2
Light reinforcement 20.10.31.5-0.3-1.20.30.2-0.20.4-0.40.00.40.20.1-0.4-0.31.2
Bone: marrow area1.74.113.93.32.93.7-0.8-1.03.3-0.4-1.1-0.10.8-2.4-0.32.10.1
Bone: maximum diameter2.14.211.43.42.92.6-2.5-2.52.0-2.11.31.8-1.4-0.2-1.60.21.3
Bone: maximum force0.40.71.30.80.80.7-0.9-1.10.3-1.10.90.9-1.10.5-1.0-0.40.9
Bone: maximum moment0.20.51.00.70.60.7-0.7-0.80.3-0.90.80.7-1.00.4-0.8-0.20.6
Mean time between licks in bursts0.00.10.5-0.6-0.4-0.70.30.20.70.1-0.1-0.10.20.2-0.5-0.30.0
Mean num. licks in bursts0.51.33.0-0.6-1.3-0.2-0.9-1.0-0.8-1.31.01.3-1.21.4-1.7-1.31.4
Cd content in liver3.94.48.6-2.1-1.5-1.62.42.80.02.8-1.6-2.61.6-1.22.51.5-2.9
Co content in liver0.50.62.5-1.2-1.2-1.40.20.3-1.60.10.30.2-0.30.8-0.3-0.80.1
Cu content in liver0.91.01.80.90.90.2-1.3-1.30.0-1.31.01.3-1.00.8-0.9-1.01.2
Fe content in liver1.21.53.01.00.80.5-1.7-1.60.6-1.51.51.5-1.51.0-1.4-0.90.7
K content in liver1.61.63.31.11.11.3-1.8-1.70.4-1.61.41.5-1.40.6-1.1-0.51.0
Mg content in liver2.83.16.01.01.21.4-2.4-2.40.4-2.41.82.3-1.81.0-1.8-1.22.1
Mn content in liver1.11.22.61.60.61.1-1.5-1.30.8-1.31.31.2-1.30.6-0.8-0.11.0
Na content in liver1.41.64.21.62.01.0-1.5-1.52.0-1.21.01.1-1.00.2-0.7-0.30.8
Rb content in liver0.10.10.5-0.3-0.2-0.1-0.4-0.30.2-0.40.70.4-0.70.6-0.1-0.3-0.1
Se content in liver0.81.01.91.00.20.9-1.4-1.20.5-1.21.31.1-1.30.7-1.2-0.30.5
Sr content in liver0.40.41.1-0.9-0.4-1.00.80.90.00.8-0.3-0.70.30.10.5-0.1-0.7
Zn content in liver0.60.61.90.90.70.90.10.40.40.6-0.4-0.60.4-1.11.11.4-1.1
Bone: minimum diameter0.10.20.60.60.80.3-0.4-0.30.7-0.30.30.1-0.50.1-0.60.2-0.1
Time in familiar zone, hab. session 10.10.20.50.50.60.5-0.4-0.30.4-0.20.40.2-0.70.2-0.40.0-0.2
Time in novel zone, hab. session 10.30.30.8-0.3-0.90.10.50.6-0.70.5-0.4-0.50.8-0.40.40.6-0.5
Total zone transitions, hab. session 10.71.04.1-1.4-0.7-2.0-0.10.2-1.40.11.00.2-1.11.4-0.6-1.2-0.4
Total locomotion distance, hab. session 11.31.98.6-2.4-1.4-2.90.70.9-1.80.60.4-0.2-0.51.4-0.3-1.4-0.4
Locomotion velocity, hab. session 11.31.98.7-2.5-1.4-2.90.70.7-1.70.50.4-0.1-0.51.5-0.5-1.6-0.1
Time in familiar zone, hab. session 20.81.03.50.60.20.0-1.2-1.00.3-1.01.51.1-1.91.1-0.8-0.70.4
Time in novel zone, hab. session 21.51.74.6-0.1-0.60.81.41.3-0.31.3-1.8-1.42.2-1.61.01.5-0.9
Total zone transitions, hab. session 21.31.74.7-1.0-0.1-1.5-0.9-1.0-0.9-1.11.31.4-1.51.7-1.2-2.21.4
Total locomotion distance, hab. session 21.11.47.6-2.3-0.8-2.80.70.7-1.00.50.2-0.2-0.51.3-0.1-1.6-0.0
Locomotion velocity, hab. session 21.31.88.9-2.6-1.1-3.00.90.9-1.20.70.1-0.3-0.31.30.1-1.6-0.0
Novel to familiar place preference ratio0.30.41.00.80.60.90.10.00.40.1-0.6-0.31.0-0.80.50.70.0
Novelty place preference0.50.71.71.20.81.30.10.10.60.3-0.8-0.41.1-1.20.71.1-0.2
Time in novel zone, NPP test0.81.02.71.40.81.70.20.20.70.4-0.9-0.61.3-1.50.81.5-0.4
Total zone transitions, NPP test0.71.13.0-1.1-0.1-1.7-0.5-0.5-0.5-0.61.10.9-1.21.5-0.9-1.70.7
Total locomotion distance, NPP test0.40.64.0-1.10.1-2.00.30.5-0.20.50.3-0.2-0.40.80.2-0.9-0.4
Locomotion velocity, NPP test0.70.96.5-1.6-0.0-2.50.40.5-0.30.40.5-0.1-0.51.10.1-1.3-0.2
Intraocular pressure0.30.41.00.50.20.5-0.9-0.90.1-1.00.61.0-0.40.5-0.6-0.50.5
Delta distance traveled before/after self-admin0.30.41.20.9-0.10.50.30.5-0.30.5-0.3-0.60.3-0.7-0.31.1-0.9
Delta ambulatory time before/after self-admin0.30.52.21.30.11.00.20.40.20.5-0.3-0.70.2-0.9-0.21.5-0.9
Parametrial fat weight0.20.52.30.20.0-0.50.30.8-0.90.9-0.1-0.70.3-0.50.80.8-1.5
Pavlov. Cond. lever latency0.30.32.2-0.2-1.50.3-0.20.0-1.0-0.40.60.2-0.30.6-0.30.2-0.1
Pavlov. Cond. magazine entry latency2.22.85.2-0.60.3-0.52.22.00.82.3-2.2-2.31.8-1.71.71.4-1.8
Pavlov. Cond. change in total contacts1.21.32.7-0.80.8-0.51.61.21.21.5-1.7-1.51.3-1.10.80.4-0.8
Pavlov. Cond. index score1.21.53.3-0.30.9-0.31.51.21.21.5-1.8-1.51.4-1.51.10.7-0.8
Pavlov. Cond. latency score0.70.91.8-0.30.9-0.51.10.90.91.2-1.3-1.11.0-1.10.80.4-0.6
Pavlov. Cond. lever contacts0.80.91.8-0.01.2-0.21.00.71.21.1-1.3-1.01.1-1.21.10.5-0.5
Pavlov. Cond. magazine entry number1.51.94.10.8-0.30.4-1.9-1.6-0.7-1.82.01.8-1.61.4-1.3-0.91.1
Pavlov. Cond. intertrial magazine entries0.40.51.10.40.50.5-1.0-1.00.1-0.90.70.9-0.50.3-0.6-0.60.8
Pavlov. Cond. lever-magazine prob. diff.1.72.14.6-0.41.0-0.31.81.41.51.8-2.2-1.81.7-1.71.21.0-0.9
Pavlov. Cond. response bias1.92.34.7-0.31.0-0.31.91.61.41.9-2.2-1.91.8-1.81.61.2-1.2
Pavlov. Cond. lever latency3.04.27.5-1.2-0.8-1.02.62.7-0.12.7-2.4-2.72.2-1.52.31.7-2.6
Pavlov. Cond. magazine entry latency0.40.51.3-1.1-0.8-1.0-0.2-0.1-0.6-0.30.90.5-0.61.1-0.5-1.00.3
Pavlov. Cond. change in total contacts1.94.68.20.70.40.4-2.7-2.60.1-2.72.92.7-2.52.1-2.5-2.02.2
Pavlov. Cond. index score1.62.54.60.50.30.4-2.0-2.0-0.2-2.02.22.1-1.91.5-1.6-1.51.8
Pavlov. Cond. latency score1.82.95.10.40.20.3-2.1-2.1-0.3-2.22.32.2-2.01.7-1.8-1.71.9
Pavlov. Cond. lever contacts2.84.17.51.41.01.3-2.6-2.70.3-2.62.32.6-2.11.3-2.2-1.52.5
Pavlov. Cond. magazine entry number0.30.40.60.50.40.20.50.50.30.7-0.8-0.70.6-0.80.80.8-0.7
Pavlov. Cond. intertrial magazine entries0.10.20.80.90.90.3-0.3-0.30.7-0.2-0.10.1-0.0-0.2-0.10.2-0.1
Pavlov. Cond. lever-magazine prob. diff.1.82.75.10.40.30.2-2.1-2.0-0.3-2.12.32.2-1.91.7-1.7-1.71.8
Pavlov. Cond. response bias1.41.93.30.60.60.5-1.7-1.80.2-1.81.71.8-1.41.0-1.6-1.21.8
Time in closed arm before self-admin0.50.93.51.61.21.9-0.7-0.71.0-0.4-0.30.20.4-1.1-0.00.80.2
Time in closed arm after self-admin0.30.40.80.80.60.6-0.8-0.70.9-0.70.40.4-0.60.2-0.60.00.3
Time in open arm before self-admin0.30.41.1-0.1-0.3-0.50.80.80.60.8-0.4-0.70.4-0.31.00.5-0.7
Time in open arm after self-admin0.60.61.10.5-0.10.50.80.8-0.30.8-0.8-0.81.1-1.01.11.1-0.6
Bone: periosteal estimation1.12.78.93.02.62.8-1.4-1.42.3-1.00.10.6-0.3-1.2-1.01.10.4
Bone: periosteal perimeter1.32.57.92.82.42.1-1.8-1.81.6-1.51.01.3-1.1-0.2-0.90.31.0
Bone: post-yield work0.71.24.51.82.11.6-0.7-1.01.5-0.7-0.20.50.1-0.8-0.50.40.9
Progressive ratio test 1 active lever presses0.91.53.40.4-0.31.11.31.30.71.3-1.4-1.61.4-1.60.91.9-1.2
Progressive ratio test 1 breakpoint0.81.33.30.5-0.31.21.11.10.71.2-1.2-1.51.2-1.50.81.8-1.1
Progressive ratio test 1 inactive lever presses0.71.93.60.80.50.8-1.9-1.7-1.1-1.81.91.8-1.61.1-0.9-0.91.3
Progressive ratio test 2 active lever presses0.00.10.5-0.2-0.50.4-0.00.1-0.7-0.10.00.10.20.0-0.00.1-0.0
Progressive ratio test 2 breakpoint0.10.10.5-0.2-0.40.4-0.1-0.0-0.7-0.20.20.20.10.1-0.2-0.00.0
Progressive ratio test 2 inactive lever presses0.10.21.60.1-0.50.50.00.1-1.2-0.0-0.10.10.5-0.20.70.20.1
Incentive Sensitization - Responses0.41.02.6-0.7-0.9-0.4-0.9-0.7-1.6-1.00.91.3-0.61.2-0.6-1.40.9
Incentive Sensitization - Breakpoint0.51.03.0-0.9-0.9-0.6-0.8-0.7-1.7-0.90.91.3-0.61.3-0.6-1.50.8
Sum of active levers in priming session hrs 5-60.60.61.6-0.20.3-0.50.70.80.60.9-0.8-0.80.9-0.51.30.5-0.9
Progressive ratio0.82.33.70.10.40.61.61.61.31.8-1.6-1.91.9-1.91.61.9-1.6
Food seeking constrained by brief footshock0.91.12.40.61.30.9-1.4-1.5-0.2-1.20.91.2-0.90.2-1.6-0.61.0
Seeking ratio, punishment vs. effort1.73.76.20.30.60.2-2.3-2.4-0.9-2.42.12.4-2.41.8-2.5-2.02.1
Retroperitoneal fat weight0.41.84.8-0.6-0.4-2.2-1.0-0.5-1.6-0.62.21.0-2.01.9-0.2-1.4-0.1
Reaction time number correct0.31.12.61.41.00.7-1.5-1.30.5-1.01.61.0-1.60.3-0.5-0.20.4
Reaction time mean minus median0.21.01.7-1.1-1.3-0.11.31.2-0.61.0-1.2-1.11.0-0.61.20.7-0.6
Reaction time mean minus median AUC0.21.43.0-0.7-1.0-0.21.41.5-0.21.4-1.3-1.51.0-0.81.71.2-1.2
Reaction time num false alarms0.20.41.6-1.10.0-1.30.10.3-0.60.10.6-0.0-0.60.80.2-0.60.2
Reaction time num false alarms AUC0.20.51.1-0.70.3-1.0-0.5-0.3-0.6-0.41.00.5-1.11.0-0.1-0.80.5
Reaction time trials correct on left0.31.12.61.41.00.7-1.5-1.30.5-1.01.61.0-1.60.3-0.5-0.20.4
Reaction time trials on left0.31.22.71.41.10.8-1.6-1.30.6-1.01.61.1-1.70.3-0.5-0.20.4
Reaction time mean0.41.02.7-1.4-1.6-0.60.91.1-1.60.8-0.8-0.70.8-0.01.10.3-0.7
Reaction time mean AUC0.30.71.9-1.2-1.4-0.30.80.9-1.40.7-0.9-0.60.8-0.11.00.3-0.5
Median of all reaction times0.71.03.2-1.6-1.8-0.90.81.0-1.70.7-0.6-0.50.70.21.00.0-0.7
Reaction time omissions0.10.10.50.00.20.2-0.2-0.20.7-0.30.40.1-0.40.20.50.1-0.1
Reaction time false alarm rate0.30.42.1-1.4-0.3-1.50.50.6-0.70.30.1-0.2-0.10.70.2-0.50.0
Reaction time premature initiation rate0.30.52.41.50.81.4-0.7-0.40.6-0.20.30.1-0.1-0.80.30.80.0
Reaction time premature initiations0.41.24.32.11.21.7-1.5-1.20.7-0.81.10.8-1.0-0.4-0.20.60.4
Std. dev. reaction times0.20.81.3-1.0-1.1-0.01.01.1-0.70.9-0.9-1.00.8-0.41.10.8-0.8
Reaction time trials completed0.31.22.71.41.10.8-1.6-1.30.6-1.01.61.1-1.70.3-0.5-0.20.4
Reaction time trials AUC0.30.92.31.21.00.7-1.4-1.20.4-0.91.50.9-1.50.3-0.5-0.10.3
Run reversals in cocaine runway, females0.40.51.3-0.4-1.1-0.5-0.4-0.4-0.4-0.70.70.6-0.81.0-0.8-0.80.5
Run reversals in cocaine runway, males1.31.42.60.61.50.4-1.6-1.6-0.1-1.50.81.5-1.10.9-1.2-1.21.4
Latency to leave start box in cocaine runway0.20.20.9-0.8-0.7-0.00.2-0.1-0.3-0.3-0.60.30.20.3-0.3-0.61.0
Latency to leave start box in cocaine runway, F0.20.20.8-0.6-0.4-0.20.0-0.2-0.3-0.4-0.00.4-0.20.5-0.5-0.60.9
Latency to leave start box in cocaine runway, M0.30.21.0-1.0-0.9-0.20.2-0.0-0.4-0.2-0.50.20.20.2-0.1-0.70.7
Std. dev. time between licks in bursts1.32.43.90.71.00.2-1.8-2.00.9-2.01.61.9-1.51.3-1.9-1.51.9
Total sessions with >9 infusions0.10.20.70.60.30.90.00.10.40.2-0.0-0.30.0-0.5-0.30.7-0.3
Short access day 1 total inactive lever presses0.81.73.20.5-0.60.7-1.6-1.4-1.3-1.81.61.6-1.41.3-1.3-0.81.1
Short access day 10 total inactive lever presses0.21.22.40.30.30.1-1.5-1.3-0.7-1.41.31.5-1.21.2-1.0-1.00.8
Short access day 1 total infusions0.40.91.60.1-0.10.21.11.10.61.2-1.0-1.31.0-1.10.61.2-1.1
Short access day 10 total infusions0.81.33.20.90.11.40.90.90.51.0-1.2-1.21.2-1.70.71.8-1.0
Short access total infusions1.21.73.70.4-0.21.01.31.40.51.5-1.5-1.71.4-1.70.91.9-1.5
Short access day 1 locomotion0.40.71.20.60.90.40.50.61.10.8-0.7-0.80.9-1.10.91.0-0.7
Short access day 10 total locomotion0.20.81.70.50.80.6-1.3-1.10.4-1.11.01.2-1.00.6-1.1-0.60.9
Short access total locomotion0.00.10.40.30.10.5-0.1-0.10.6-0.00.10.1-0.1-0.2-0.40.20.1
One hour access (0.3 mA shock)0.81.01.8-0.5-0.7-0.51.11.3-1.21.4-0.9-1.11.1-0.70.90.8-1.2
Compulsive drug intake0.30.51.90.8-0.20.1-0.8-0.6-0.4-0.70.70.7-1.00.6-1.4-0.20.1
One hour access (shock baseline)0.71.83.0-0.9-0.8-0.51.71.7-0.81.7-1.4-1.61.6-1.11.70.9-1.3
Social response proportion1.82.38.7-2.4-3.0-2.01.21.0-2.90.4-0.3-0.20.41.20.6-1.00.2
Social responses1.01.34.2-0.7-1.6-2.0-0.10.1-2.0-0.21.20.5-1.11.50.2-1.20.2
Social time0.20.41.1-0.5-1.1-1.00.60.6-1.00.4-0.2-0.30.10.30.8-0.2-0.2
Soleus weight2.36.725.73.95.12.4-2.5-2.94.1-2.10.61.8-0.7-0.7-1.7-0.21.9
Bone: stiffness0.10.10.3-0.10.5-0.2-0.2-0.3-0.1-0.40.40.3-0.50.4-0.4-0.50.4
Tibialis anterior weight2.06.823.14.84.44.3-2.0-2.23.8-1.3-0.30.90.2-2.2-0.21.60.8
Time to tail flick, vehicle, before self-admin1.72.13.8-0.5-0.1-0.21.91.71.01.8-2.0-1.81.9-1.51.61.3-1.3
Time to tail flick, vehicle, after self-admin0.30.63.80.4-0.21.00.40.21.90.3-1.0-0.50.7-0.90.40.7-0.1
Time to tail flick, test, before self-admin0.20.20.9-0.00.10.60.40.30.90.3-0.6-0.60.4-0.6-0.00.6-0.4
Time to tail flick, test, after self-admin0.40.51.7-0.0-0.3-0.40.50.80.40.9-0.4-1.00.2-0.50.60.8-1.3
Delta time to tail flick, vehicle, before/after SA0.80.81.60.60.40.6-1.2-1.20.8-1.20.91.1-1.00.5-0.8-0.60.9
Delta time to tail flick, test, before/after SA0.10.10.40.6-0.5-0.1-0.20.0-0.70.00.3-0.0-0.40.10.00.2-0.4
Tibia length0.20.43.40.6-0.31.8-0.0-0.20.2-0.3-0.60.00.4-0.8-0.60.70.4
Ambulatory time before self-admin0.20.71.91.21.41.0-1.0-1.01.3-0.80.10.8-0.1-0.30.2-0.10.7
Ambulatory time after self-admin0.81.25.72.41.32.0-0.8-0.71.3-0.4-0.10.20.1-1.0-0.21.2-0.1
Bone: tissue strength0.80.92.3-1.5-0.8-1.50.3-0.1-0.9-0.40.50.5-0.71.4-0.5-1.41.0
Total heroin consumption0.30.41.2-0.00.5-0.20.50.60.50.6-0.7-0.70.7-0.41.10.6-0.7
Bone: trabecular number0.61.16.11.62.50.0-0.8-0.82.2-0.50.40.4-0.3-0.1-0.3-0.10.3
Bone: trabecular spacing2.23.210.7-3.0-3.0-2.60.30.6-3.30.11.00.3-0.92.0-0.5-1.6-0.2
Bone: trabecular thickness1.11.54.32.11.80.8-1.6-1.41.2-1.21.51.1-1.40.5-0.5-0.00.5
Bone: trabecular tissue density0.20.41.60.1-1.31.00.20.4-0.80.2-0.0-0.40.2-0.20.40.9-0.6
Water consumed over 24 hours1.01.93.71.81.01.8-1.9-1.90.6-1.81.21.6-1.10.2-1.2-0.31.4
Number of responses in last shaping day2.33.010.02.02.12.30.20.23.20.9-1.1-1.11.2-2.51.02.3-1.1