Hub : Genes

Mkrn2os

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Mkrn2os	0.09	0.05	2.4e-07	0.06	0.06	0.06	0.07	7.0e-07	5.6e-07	8.3e-07	7.4e-08
2	Adipose	gene expression	Mkrn2os	0.02	0.01	7.8e-03	0	0.01	0.01	0.01	1.3e-01	6.4e-02	3.8e-02	5.0e-02
3	Adipose	isoform ratio	XM_008763263.3	0.02	0.01	3.9e-03	0.01	0.02	0.01	0.01	9.2e-03	6.4e-03	4.6e-02	1.3e-02
4	Adipose	isoform ratio	XM_039108781.2	0.02	0.01	6.0e-03	0.01	0.01	0.01	0.01	1.0e-02	8.6e-03	7.0e-02	1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.2	0.6	-0.8	-0.1	-0.3	0.3
Area under the delay curve	0.1	0.1	0.2	0.3	0.4	-0.0	0.0
BMI with tail	0.9	3.1	3.9	2.0	1.1	1.9	-1.9
BMI without tail	0.1	0.4	0.8	0.4	0.3	0.9	-0.9
Body weight	0.2	1.0	2.1	1.4	0.2	1.0	-1.0
Weight adjusted by age	0.2	0.2	0.5	0.2	0.7	0.5	-0.5
Bone surface	0.2	0.4	1.2	-1.1	-0.2	-0.5	0.5
Bone volume	0.2	0.4	0.6	-0.8	-0.3	-0.6	0.6
Breakpoint value in progressive ratio session	0.3	0.4	0.7	0.8	-0.2	-0.6	0.6
Number of licking bursts	0.4	0.6	1.4	-1.2	-0.7	-0.5	0.5
Context. condit. distance diff. score	1.4	1.7	2.4	1.6	1.4	1.1	-1.1
Locomotion velocity, session 1	0.3	0.4	0.5	-0.5	-0.7	-0.6	0.6
Locomotion distance, session 1	1.3	1.6	2.8	-1.4	-1.7	-0.9	0.9
Locomotion velocity, session 2	0.8	1.0	2.0	-1.4	-0.7	-0.8	0.8
Locomotion distance, session 2	2.8	3.9	4.9	-2.2	-2.2	-1.8	1.7
Locomotion velocity, session 3	0.3	0.3	0.4	-0.6	0.4	0.6	-0.6
Locomotion distance, session 3	0.4	0.5	0.6	-0.8	0.5	0.7	-0.7
Stereotopy head waving bouts, day 3	0.9	1.1	1.6	-0.8	-0.8	-1.2	1.3
Stereotopy head waving duration, day 3	1.5	1.8	2.6	-0.8	-1.3	-1.6	1.6
Locomotion velocity, session 7	0.1	0.1	0.5	-0.7	0.2	0.1	-0.1
Locomotion distance, session 7	0.1	0.2	0.3	0.2	0.3	0.5	-0.5
Stereotopy head waving bouts, day 7	0.7	0.8	2.3	-1.5	-0.3	-0.6	0.6
Stereotopy head waving duration, day 7	1.2	1.5	3.1	-1.8	-0.7	-1.1	1.1
Locomotion velocity, session 8	0.3	0.4	0.6	-0.8	-0.5	-0.6	0.6
Locomotion distance, session 8	0.1	0.2	0.4	-0.2	-0.6	-0.3	0.3
Degree of sensitization distance	0.5	0.5	0.6	0.6	-0.7	-0.7	0.8
Degree of sensitization stereotypy	0.2	0.2	0.6	-0.8	0.2	0.0	-0.0
Conditioned locomotion	2.6	3.0	4.1	0.9	1.7	2.0	-2.0
Cocaine response after cond. corrected	4.7	5.7	7.7	-2.8	-2.1	-2.3	2.3
Cocaine response after cond. not corrected	5.2	6.1	8.5	-2.9	-2.2	-2.4	2.4
Cocaine response before conditioning	0.0	0.0	0.0	0.2	0.1	-0.1	0.1
Saline control response	0.8	1.1	2.1	-0.4	1.4	1.0	-1.1
Bone: connectivity density	0.5	0.8	1.1	-1.0	-0.9	-0.9	0.8
Bone: cortical apparent density	0.3	0.3	0.4	-0.5	-0.6	-0.6	0.6
Bone: cortical area	0.0	0.1	0.1	-0.1	0.4	-0.3	0.3
Bone: cortical porosity	0.6	0.7	1.0	-0.4	-0.9	-1.0	1.0
Bone: cortical porosity	0.4	0.4	0.6	0.1	-0.6	-0.8	0.8
Bone: cortical thickness	0.3	0.5	0.7	-0.6	-0.3	-0.8	0.8
Bone: cortical thickness	0.1	0.1	0.2	-0.3	0.4	0.1	-0.0
Bone: cortical tissue density	0.3	0.4	0.4	-0.5	-0.6	-0.6	0.6
Condit. Reinf. active minus inactive responses	0.6	0.6	1.5	-1.2	-0.6	-0.6	0.6
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.2	-1.5	-0.9	-0.7	0.7
Condit. Reinf. active responses	0.1	0.1	0.1	-0.3	0.2	0.3	-0.3
Condit. Reinf. inactive responses	0.8	1.0	1.1	0.8	1.1	1.0	-1.0
Incentive salience index mean	1.4	1.8	2.7	-1.6	-1.3	-1.1	1.1
Condit. Reinf. lever presses	1.7	2.4	3.2	-1.4	-1.8	-1.5	1.5
Condit. Reinf. active minus inactive responses	1.0	1.4	1.9	-1.4	-0.9	-1.2	1.2
Condit. Reinf. active-inactive response ratio	2.7	3.1	4.2	-1.1	-1.7	-2.0	2.0
Condit. Reinf. active responses	0.2	0.2	0.8	-0.9	0.1	-0.2	0.2
Condit. Reinf. inactive responses	2.2	2.8	3.9	0.2	2.0	1.9	-1.9
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.8	-0.2	-0.6	0.6
Condit. Reinf. lever reinforcers received	0.4	0.5	1.5	-1.2	-0.0	-0.5	0.5
Conditioned reinforcement - actives	2.6	4.5	6.0	2.4	1.9	2.1	-2.1
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.3	0.5	-0.1	0.1
Conditioned locomotion	0.2	0.2	0.4	0.6	0.7	0.2	-0.2
Patch foraging indifference point 0 sec	0.4	0.8	1.3	0.5	0.5	1.1	-1.2
Patch foraging indifference point AUC	0.2	0.3	0.6	-0.8	-0.5	-0.4	0.4
Delay disc. indifference point, 0s delay	1.5	1.6	2.3	1.3	1.5	1.2	-1.2
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	-0.1	-0.0	-0.2	0.2
Delay disc. indifference point, 2s delay	0.8	0.9	1.8	1.4	1.2	0.5	-0.5
Delay disc. indifference point, 24s delay	0.4	0.5	1.2	-1.1	-0.7	-0.3	0.2
Delay disc. indifference point, 4s delay	0.4	0.4	0.8	0.7	0.9	0.4	-0.4
Delay disc. indifference point, 8s delay	0.1	0.2	0.3	-0.3	-0.2	-0.5	0.5
Indifference point function ln k	0.1	0.2	0.9	0.9	0.1	-0.2	0.2
Indifference point function log k	0.1	0.2	0.9	0.9	0.1	-0.2	0.2
Patch foraging total patch changes 0 sec	0.4	0.7	1.1	0.7	0.3	1.0	-1.0
Patch foraging total patch changes 12 sec	0.1	0.2	0.3	-0.6	-0.6	0.0	-0.0
Patch foraging total patch changes 18 sec	0.1	0.2	0.4	-0.4	-0.2	0.6	-0.6
Patch foraging total patch changes 24 sec	1.1	1.9	2.7	0.8	1.2	1.6	-1.6
Patch foraging total patch changes 6 sec	0.3	0.5	0.7	0.8	0.6	0.7	-0.7
Patch foraging time to switch 0 sec	0.2	0.5	0.7	0.6	0.8	0.7	-0.7
Patch foraging water rate 0 sec	0.4	0.8	2.3	-0.4	-1.5	-0.6	0.6
Patch foraging water rate 12 sec	0.2	0.4	0.7	-0.0	-0.8	-0.6	0.6
Patch foraging water rate 18 sec	0.2	0.3	1.0	1.0	0.2	0.3	-0.3
Patch foraging water rate 24 sec	0.6	0.8	1.9	-0.2	-1.4	-0.8	0.8
Patch foraging water rate 6 sec	0.9	1.4	2.8	-1.0	-1.7	-0.9	0.9
Seeking ratio, delayed vs. immediate footshock	1.0	1.2	3.0	1.7	0.7	0.8	-0.8
Distance traveled before self-admin	0.4	0.6	0.9	-1.0	-0.5	-0.7	0.7
Distance traveled after self-admin	0.1	0.1	0.2	0.1	0.4	0.3	-0.3
Extensor digitorum longus weight	2.6	10.2	27.7	5.3	2.2	2.1	-2.0
Bone: elastic displacement	1.1	1.3	2.0	0.8	1.4	1.1	-1.1
Bone: elastic work	0.1	0.1	0.2	0.5	0.4	0.0	-0.0
Bone: endosteal estimation	0.3	0.6	0.9	0.7	1.0	0.7	-0.7
Bone: endosteal perimeter	0.3	0.6	1.2	0.5	1.1	0.6	-0.7
Epididymis fat weight	0.5	1.8	2.6	0.7	1.6	1.4	-1.4
Delta time in closed arm before/after self-admin	0.4	0.4	0.6	-0.3	-0.4	-0.8	0.8
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.3	-0.1	0.1	-0.1
Diff in mean of infusions in LGA sessions	0.3	0.3	0.5	0.4	0.3	0.7	-0.7
Delay discount exponential model param	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.0
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.3	0.5	0.4	-0.4
Active lever presses in extinction session 6	0.1	0.1	0.3	0.6	-0.0	-0.0	0.0
Bone: final force	0.1	0.1	0.3	0.5	0.2	0.1	-0.1
Bone: final moment	0.1	0.2	0.4	0.6	0.5	0.4	-0.4
Food consumed during 24 hour testing period	0.2	0.2	0.5	0.2	0.7	0.4	-0.4
Glucose	0.8	1.3	3.3	1.8	0.6	0.9	-0.9
Heart weight	0.3	0.4	0.5	0.7	0.7	0.6	-0.6
Delay discount hyperbolic model param	0.1	0.1	0.3	-0.5	-0.6	-0.1	0.1
Intermittent access intake day 1-15 change	0.2	0.5	1.1	1.0	0.9	0.1	-0.1
Intermittent access intake escalation	0.3	0.7	1.5	1.2	1.1	0.3	-0.3
Intermittent access intake escalation 2	0.6	0.7	1.7	1.3	0.6	-0.7	0.7
Intermitt. access day 1 inactive lever presses	0.4	1.7	2.7	-1.6	-0.5	-1.4	1.4
Intermitt. access day 15 inactive lever presses	0.3	0.6	1.3	-1.1	0.5	-0.7	0.6
Intermitt. access escalation Index	0.5	0.6	2.0	-0.6	-1.4	-0.4	0.4
Intermittent access day 1 total infusions	0.5	0.8	1.1	0.9	0.6	1.0	-1.0
Intermittent access day 15 total infusions	3.4	5.1	6.9	2.6	2.1	2.1	-2.1
Intermittent access terminal intake (last 3 days)	3.8	5.0	8.2	2.9	2.0	2.0	-2.0
Intermittent access total infusions	4.3	5.0	6.3	2.5	1.9	2.3	-2.2
Intermittent access day 1 locomotion	0.8	1.0	2.2	1.5	1.0	0.7	-0.7
Intermittent access day 15 total locomotion	1.4	2.6	4.1	2.0	1.7	1.3	-1.2
Intermittent access total locomotion	2.4	2.8	5.2	2.3	1.4	1.4	-1.4
Intermittent access standard deviation	0.2	0.5	1.2	0.7	1.1	0.3	-0.3
Left kidney weight	1.1	5.0	6.1	-2.0	-2.5	-2.2	2.2
Right kidney weight	1.1	5.0	6.1	-2.5	-2.3	-2.1	2.1
Cocaine induced anxiety	0.4	0.6	1.3	-1.1	-0.4	0.6	-0.7
Post-drug Anxiety	1.5	1.6	5.1	-2.3	-0.8	-0.5	0.5
Baseline Anxiety	0.3	0.3	0.4	-0.5	0.6	-0.6	0.6
Tail length	0.2	0.9	1.2	-1.1	-1.0	-0.9	0.8
Length with tail	0.0	0.1	0.3	0.0	-0.6	-0.3	0.3
Length without tail	0.3	1.1	1.7	1.3	0.7	1.0	-1.0
Times rat made contact with spout	0.3	0.4	0.6	-0.7	-0.6	-0.5	0.5
Lifetime Intake	3.1	3.8	4.7	2.2	1.6	2.0	-2.0
Liver weight, left	0.5	0.9	1.7	-0.3	-1.3	-0.9	0.9
Liver weight, right	1.0	1.7	2.7	-0.9	-1.6	-1.3	1.3
Locomotor activity	0.5	0.7	2.2	-1.5	-0.8	-0.3	0.2
Locomotor testing distance	0.5	0.9	2.0	-1.4	-1.0	-0.6	0.5
Locomotor testing rearing	0.8	1.6	2.1	-0.8	1.4	1.4	-1.4
Locomotion in novel chamber	1.0	1.3	2.9	-0.5	-1.7	-1.0	1.0
Locomotion in novel chamber post-restriction	6.3	10.4	14.0	-1.7	-3.7	-3.5	3.5
Fecal boli incidents, locomotor time 1	0.5	0.7	1.2	-1.1	-1.0	-0.5	0.5
Change in fecal boli incidents, locomotor task	0.3	0.3	0.4	0.6	0.2	0.6	-0.6
Time >=10cm from walls, locomotor time 1	1.8	1.9	3.8	-2.0	-1.2	-1.1	1.1
Bouts of movement, locomotor time 1	0.4	0.4	0.6	0.5	0.6	0.7	-0.8
Total resting periods, locomotor time 1	0.7	0.8	0.9	0.9	0.9	0.9	-0.9
Rest time, locomotor task time 1	0.8	1.0	3.0	1.7	0.2	0.7	-0.6
Distance moved, locomotor task time 1	0.9	1.4	3.9	-2.0	-0.0	-0.9	0.9
Vertical activity count, locomotor time 1	0.1	0.2	0.6	-0.8	0.4	-0.0	0.0
Time >=10cm from walls, locomotor time 2	0.5	0.8	1.8	-1.4	-0.9	-0.4	0.4
Bouts of movement, locomotor time 2	0.1	0.2	0.8	-0.9	0.0	-0.3	0.2
Total resting periods, locomotor time 2	0.2	0.4	1.2	-1.1	-0.2	-0.4	0.3
Rest time, locomotor task time 2	0.2	0.2	0.5	0.7	0.3	0.3	-0.3
Distance moved, locomotor task time 2	0.5	0.6	1.1	-1.1	-0.2	-0.8	0.8
Vertical activity count, locomotor time 2	0.4	0.6	1.0	-0.4	-0.4	-1.0	1.0
Light reinforcement 1	0.1	0.2	0.3	-0.6	-0.5	-0.4	0.4
Light reinforcement 2	0.0	0.0	0.1	-0.1	-0.3	0.1	-0.1
Bone: marrow area	0.3	0.6	0.9	0.6	0.9	0.7	-0.7
Bone: maximum diameter	0.1	0.3	0.4	-0.5	0.2	-0.6	0.6
Bone: maximum force	0.3	0.5	1.1	1.1	0.7	0.4	-0.4
Bone: maximum moment	0.4	0.7	1.2	1.1	0.9	0.6	-0.6
Mean time between licks in bursts	0.0	0.0	0.1	0.0	0.0	-0.3	0.3
Mean num. licks in bursts	0.0	0.0	0.2	0.4	-0.0	-0.0	0.0
Cd content in liver	0.1	0.1	0.2	-0.0	-0.5	-0.2	0.3
Co content in liver	0.1	0.1	0.2	0.4	0.4	0.0	0.0
Cu content in liver	0.9	1.1	1.3	1.1	1.0	1.0	-1.1
Fe content in liver	0.9	1.0	3.1	1.8	0.6	0.6	-0.6
K content in liver	1.2	1.1	1.6	-1.1	-0.5	-1.3	1.2
Mg content in liver	0.1	0.1	0.4	-0.1	0.7	-0.1	0.1
Mn content in liver	0.1	0.1	0.4	-0.6	0.2	-0.2	0.2
Na content in liver	0.2	0.2	0.3	-0.3	0.6	0.4	-0.4
Rb content in liver	0.2	0.2	0.5	-0.1	0.7	0.3	-0.3
Se content in liver	0.5	0.5	2.2	1.5	0.1	0.1	-0.1
Sr content in liver	0.8	0.7	0.8	-0.9	-0.8	-0.9	0.8
Zn content in liver	0.4	0.5	0.8	-0.2	-0.4	-0.9	0.9
Bone: minimum diameter	0.7	1.3	3.1	1.8	1.3	0.6	-0.6
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.6	-0.2	0.1	-0.2
Time in novel zone, hab. session 1	0.1	0.1	0.1	0.4	-0.3	-0.2	0.2
Total zone transitions, hab. session 1	0.4	0.5	1.2	-1.1	-0.2	0.7	-0.7
Total locomotion distance, hab. session 1	0.5	0.8	1.4	-0.2	0.4	1.2	-1.2
Locomotion velocity, hab. session 1	0.3	0.4	0.7	-0.3	0.3	0.8	-0.8
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.0	0.2	0.3	-0.4
Time in novel zone, hab. session 2	0.3	0.3	0.4	-0.2	-0.5	-0.6	0.6
Total zone transitions, hab. session 2	1.3	1.7	3.7	-1.9	-1.4	-0.7	0.7
Total locomotion distance, hab. session 2	1.4	1.8	4.2	-2.1	-1.5	-0.7	0.6
Locomotion velocity, hab. session 2	1.1	1.5	3.6	-1.9	-1.3	-0.6	0.5
Novel to familiar place preference ratio	0.1	0.1	0.3	0.5	0.2	-0.1	0.1
Novelty place preference	0.1	0.1	0.3	0.5	0.0	-0.2	0.3
Time in novel zone, NPP test	0.2	0.2	0.6	0.8	0.3	0.1	-0.1
Total zone transitions, NPP test	1.9	2.7	4.3	-1.8	-2.1	-1.3	1.3
Total locomotion distance, NPP test	0.4	0.6	1.5	-0.7	-1.2	-0.5	0.5
Locomotion velocity, NPP test	0.9	1.3	2.3	-1.1	-1.5	-0.9	0.9
Intraocular pressure	0.1	0.1	0.2	-0.1	-0.5	-0.4	0.4
Delta distance traveled before/after self-admin	4.9	5.2	6.2	2.0	2.1	2.5	-2.5
Delta ambulatory time before/after self-admin	2.1	2.6	3.0	1.5	1.5	1.7	-1.7
Parametrial fat weight	0.1	0.3	0.4	-0.4	-0.5	-0.6	0.6
Pavlov. Cond. lever latency	0.0	0.1	0.1	0.2	0.2	0.2	-0.2
Pavlov. Cond. magazine entry latency	2.3	2.9	3.1	-1.7	-1.6	-1.7	1.7
Pavlov. Cond. change in total contacts	0.7	0.7	1.3	-0.6	-1.2	-0.8	0.8
Pavlov. Cond. index score	0.5	0.6	0.6	-0.8	-0.7	-0.8	0.8
Pavlov. Cond. latency score	0.6	0.8	0.8	-0.8	-0.9	-0.9	0.9
Pavlov. Cond. lever contacts	0.1	0.2	0.3	-0.2	-0.5	-0.4	0.4
Pavlov. Cond. magazine entry number	1.4	1.7	1.9	1.3	1.2	1.4	-1.4
Pavlov. Cond. intertrial magazine entries	2.1	2.6	4.2	0.9	2.0	1.6	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	0.9	-0.9	-1.0	-1.0	1.0
Pavlov. Cond. response bias	1.5	1.8	2.0	-1.3	-1.3	-1.4	1.4
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.5	0.2	0.6	-0.7
Pavlov. Cond. magazine entry latency	1.3	1.5	2.2	-0.9	-0.9	-1.5	1.5
Pavlov. Cond. change in total contacts	2.1	3.4	4.2	-1.7	-1.5	-2.0	2.0
Pavlov. Cond. index score	1.0	1.3	1.8	-0.9	-0.9	-1.3	1.4
Pavlov. Cond. latency score	1.5	1.9	2.7	-1.0	-1.1	-1.6	1.7
Pavlov. Cond. lever contacts	0.3	0.4	0.6	-0.6	-0.3	-0.8	0.8
Pavlov. Cond. magazine entry number	2.7	3.3	4.2	1.6	1.5	2.1	-2.0
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.6	0.1	0.4	0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	2.2	-1.1	-1.0	-1.5	1.5
Pavlov. Cond. response bias	0.4	0.6	0.8	-0.9	-0.4	-0.9	0.9
Time in closed arm before self-admin	0.1	0.1	0.2	-0.2	0.0	0.4	-0.4
Time in closed arm after self-admin	0.1	0.1	0.1	-0.0	-0.2	-0.3	0.3
Time in open arm before self-admin	0.1	0.1	0.3	0.5	0.2	-0.3	0.3
Time in open arm after self-admin	0.1	0.1	0.4	0.6	0.3	0.2	-0.2
Bone: periosteal estimation	0.1	0.3	0.9	0.4	0.9	0.3	-0.3
Bone: periosteal perimeter	0.1	0.1	0.2	-0.4	0.5	-0.0	0.0
Bone: post-yield work	0.1	0.2	0.4	-0.3	-0.0	-0.6	0.6
Progressive ratio test 1 active lever presses	1.7	2.1	3.1	1.1	1.0	1.8	-1.8
Progressive ratio test 1 breakpoint	1.6	1.9	2.9	1.0	1.0	1.7	-1.7
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	-0.4	0.3	0.1	-0.1
Progressive ratio test 2 active lever presses	4.6	5.4	7.3	2.7	1.9	2.3	-2.3
Progressive ratio test 2 breakpoint	4.8	5.5	7.5	2.7	1.9	2.3	-2.3
Progressive ratio test 2 inactive lever presses	0.9	1.5	1.6	1.1	1.2	1.3	-1.3
Incentive Sensitization - Responses	2.2	3.0	5.4	2.3	1.3	1.6	-1.6
Incentive Sensitization - Breakpoint	2.5	3.2	6.0	2.4	1.4	1.6	-1.6
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	0.2	-0.2	0.2
Progressive ratio	0.1	0.1	0.3	0.5	0.3	0.3	-0.3
Food seeking constrained by brief footshock	1.3	1.6	2.0	1.4	1.4	1.1	-1.1
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	0.4	0.4	0.3	-0.3
Retroperitoneal fat weight	0.0	0.0	0.1	-0.2	0.3	0.1	-0.2
Reaction time number correct	0.6	1.2	1.3	1.1	1.0	1.1	-1.1
Reaction time mean minus median	0.1	0.1	0.3	0.4	0.5	0.2	-0.2
Reaction time mean minus median AUC	0.0	0.1	0.2	0.5	0.2	0.2	-0.2
Reaction time num false alarms	0.1	0.2	0.3	0.6	-0.3	-0.3	0.3
Reaction time num false alarms AUC	0.3	0.5	0.8	0.0	-0.9	-0.8	0.8
Reaction time trials correct on left	0.6	1.2	1.3	1.1	1.0	1.1	-1.1
Reaction time trials on left	0.5	1.0	1.1	1.1	0.9	1.0	-1.0
Reaction time mean	0.0	0.1	0.1	-0.3	-0.3	0.2	-0.2
Reaction time mean AUC	0.0	0.1	0.1	-0.3	-0.4	0.2	-0.2
Median of all reaction times	0.1	0.1	0.3	-0.4	-0.6	0.2	-0.2
Reaction time omissions	2.3	3.4	4.5	-1.6	-2.1	-1.8	1.8
Reaction time false alarm rate	1.0	1.3	1.7	-0.6	-1.3	-1.2	1.3
Reaction time premature initiation rate	0.1	0.1	0.4	-0.6	0.1	-0.1	0.1
Reaction time premature initiations	0.1	0.2	0.4	-0.2	0.6	0.4	-0.4
Std. dev. reaction times	0.4	0.8	1.1	-0.6	-1.1	-0.9	0.9
Reaction time trials completed	0.5	1.0	1.1	1.1	0.9	1.0	-1.0
Reaction time trials AUC	0.5	0.9	1.2	1.1	0.8	0.9	-0.9
Run reversals in cocaine runway, females	2.7	2.7	3.2	-1.4	-1.6	-1.8	1.8
Run reversals in cocaine runway, males	1.2	1.2	1.9	-1.2	-1.4	-0.9	0.9
Latency to leave start box in cocaine runway	0.3	0.4	1.5	-1.2	-0.2	0.0	-0.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.6	0.2	0.3	-0.3
Latency to leave start box in cocaine runway, M	0.2	0.2	0.7	-0.8	0.0	0.3	-0.3
Std. dev. time between licks in bursts	1.5	2.0	2.7	-0.7	-1.5	-1.6	1.6
Total sessions with >9 infusions	0.9	1.1	1.4	0.7	1.1	1.2	-1.2
Short access day 1 total inactive lever presses	0.2	0.3	0.6	-0.7	0.2	0.5	-0.5
Short access day 10 total inactive lever presses	1.5	3.6	6.2	-2.5	-0.8	-2.0	1.9
Short access day 1 total infusions	0.6	0.7	1.2	0.4	0.6	1.1	-1.1
Short access day 10 total infusions	2.6	3.4	5.3	2.3	1.4	1.7	-1.7
Short access total infusions	1.4	1.7	2.2	1.1	1.2	1.5	-1.5
Short access day 1 locomotion	1.5	1.8	3.7	1.9	1.4	0.9	-0.9
Short access day 10 total locomotion	0.3	0.6	1.6	0.8	1.3	-0.3	0.3
Short access total locomotion	1.5	1.8	3.3	1.1	1.8	1.1	-1.1
One hour access (0.3 mA shock)	5.6	6.4	11.6	3.4	2.0	2.3	-2.2
Compulsive drug intake	0.1	0.1	0.1	-0.3	-0.4	0.1	-0.1
One hour access (shock baseline)	2.5	3.8	7.4	2.7	1.7	1.6	-1.5
Social response proportion	0.1	0.2	0.6	-0.8	0.1	0.0	-0.1
Social responses	0.9	1.2	2.0	-1.4	-0.6	-1.1	1.1
Social time	0.2	0.2	0.6	-0.8	-0.4	-0.2	0.2
Soleus weight	0.9	2.6	5.4	2.3	1.1	1.4	-1.4
Bone: stiffness	0.0	0.1	0.2	0.4	-0.1	-0.2	0.2
Tibialis anterior weight	2.4	8.1	10.0	2.7	3.2	2.8	-2.8
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.7	0.1	0.5	-0.5
Time to tail flick, vehicle, after self-admin	2.0	2.7	4.1	-0.3	-2.0	-1.8	1.8
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.1	0.4	0.4	-0.4
Time to tail flick, test, after self-admin	0.6	0.6	0.9	-0.4	-0.8	-0.9	0.9
Delta time to tail flick, vehicle, before/after SA	3.0	2.9	3.6	-1.0	-1.9	-1.8	1.9
Delta time to tail flick, test, before/after SA	0.5	0.5	0.8	-0.7	-0.9	-0.7	0.7
Tibia length	0.4	1.2	3.3	-1.8	-1.0	-0.5	0.5
Ambulatory time before self-admin	0.4	0.6	0.8	-0.8	-0.6	-0.9	0.9
Ambulatory time after self-admin	0.2	0.2	0.4	0.7	0.6	0.4	-0.3
Bone: tissue strength	0.5	0.5	0.8	-0.4	0.9	0.7	-0.8
Total heroin consumption	0.4	0.5	0.8	-0.4	-0.7	-0.8	0.9
Bone: trabecular number	0.2	0.3	1.0	-1.0	0.0	-0.2	0.1
Bone: trabecular spacing	0.7	0.9	1.8	1.3	0.8	0.8	-0.8
Bone: trabecular thickness	0.3	0.3	0.8	-0.9	-0.4	-0.4	0.4
Bone: trabecular tissue density	0.9	1.3	1.7	-0.5	1.2	1.3	-1.3
Water consumed over 24 hours	0.0	0.1	0.2	0.1	0.4	0.1	-0.1
Number of responses in last shaping day	1.6	1.8	3.6	1.9	1.5	0.8	-0.8