Hub : Genes

Mknk2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Mknk2 0.11 0.07 7.7e-09 0.08 0.08 0.07 0.08 3.7e-08 7.8e-08 1.8e-07 4.7e-08
2 Liver gene expression Mknk2 0.09 0.07 1.8e-04 0.03 0.01 0.02 0.02 7.2e-04 1.0e-02 3.8e-03 2.9e-03
3 BLA gene expression Mknk2 0.61 0.18 2.8e-08 0.15 0.14 0.12 0.15 2.0e-08 1.1e-07 1.0e-06 1.5e-08
4 IL gene expression Mknk2 0.15 0.11 4.1e-03 0.05 0.06 0.04 0.04 2.9e-02 1.4e-02 4.1e-02 3.5e-02
5 NAcc gene expression Mknk2 0.09 0.06 8.3e-14 0.09 0.09 0.09 0.1 9.6e-14 1.6e-13 4.2e-14 2.7e-14
6 PL gene expression Mknk2 0.3 0.21 2.4e-10 0.07 0.09 0.08 0.08 4.1e-08 1.3e-09 1.7e-09 2.1e-09
7 IC gene expression Mknk2 0.22 0.12 7.5e-09 0.11 0.1 0.09 0.11 1.7e-05 3.8e-05 1.0e-04 3.1e-05
8 pVTA gene expression Mknk2 0.18 0.11 1.6e-05 0.05 0.06 0.05 0.05 6.7e-05 2.5e-05 5.8e-05 8.3e-05
9 Adipose mRNA stability Mknk2 0.06 0.04 2.3e-05 0 0.03 0.02 0.02 8.3e-02 5.3e-04 9.8e-04 5.7e-03
10 Adipose gene expression Mknk2 0.11 0.07 7.0e-11 0.08 0.09 0.08 0.08 2.2e-09 2.5e-10 2.6e-09 1.2e-09
11 Eye intron excision ratio chr7_9690549_9690710 0.33 0.24 9.5e-03 -0 0.1 0.12 0.05 3.4e-01 1.3e-02 6.1e-03 6.4e-02
12 Brain alternative TSS XM_063263174.1 0.04 0.04 2.5e-03 0.02 0.01 0.02 0.02 4.3e-03 1.3e-02 3.3e-03 8.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.81.44.60.9-0.90.6-0.40.10.2-0.72.11.61.6-1.91.0
Area under the delay curve1.71.93.1-1.81.3-1.3-1.6-1.5-1.2-1.7-0.61.31.4-1.41.2
BMI with tail5.518.927.2-4.95.0-5.2-4.8-5.1-5.2-4.6-2.93.53.6-2.83.4
BMI without tail1.65.08.9-3.02.7-2.8-2.5-2.7-2.5-2.2-2.11.41.5-1.11.2
Body weight0.73.35.1-2.02.1-2.2-2.1-2.2-2.3-1.9-1.21.51.5-1.11.0
Weight adjusted by age0.30.41.4-0.90.9-0.8-0.6-0.6-0.5-0.4-1.2-0.1-0.00.0-0.1
Bone surface1.73.012.11.9-2.01.60.20.91.0-0.33.51.81.7-2.31.0
Bone volume1.73.011.61.9-2.01.60.20.91.1-0.33.41.81.7-2.30.8
Breakpoint value in progressive ratio session3.03.64.91.7-1.81.92.22.01.92.10.5-2.0-2.12.0-2.1
Number of licking bursts0.30.52.0-0.80.6-0.4-0.0-0.3-0.20.2-1.4-0.8-0.70.9-0.5
Context. condit. distance diff. score0.30.30.5-0.70.6-0.7-0.7-0.6-0.6-0.6-0.50.40.4-0.40.1
Locomotion velocity, session 10.70.82.71.4-1.21.00.60.80.80.41.60.30.2-0.4-0.3
Locomotion distance, session 10.91.15.41.4-1.00.70.20.50.1-0.12.31.21.1-1.10.7
Locomotion velocity, session 23.33.89.33.1-2.62.42.02.21.91.53.0-0.3-0.40.1-0.3
Locomotion distance, session 21.82.69.12.5-2.11.91.41.61.21.03.00.30.2-0.4-0.0
Locomotion velocity, session 35.05.77.42.7-2.52.62.72.62.72.61.0-2.3-2.42.0-2.0
Locomotion distance, session 30.00.00.1-0.20.1-0.10.0-0.10.10.0-0.4-0.2-0.20.2-0.3
Stereotopy head waving bouts, day 33.64.27.12.7-2.52.52.42.52.22.22.0-1.4-1.51.2-0.7
Stereotopy head waving duration, day 34.45.37.82.8-2.62.72.72.82.52.51.8-1.8-1.91.5-0.8
Locomotion velocity, session 70.70.82.10.6-1.01.00.70.91.50.80.1-0.7-0.70.3-1.4
Locomotion distance, session 70.30.41.9-0.90.6-0.5-0.4-0.5-0.1-0.1-1.4-0.4-0.40.4-0.9
Stereotopy head waving bouts, day 70.50.62.00.3-0.50.3-0.20.00.1-0.41.30.90.9-1.11.4
Stereotopy head waving duration, day 70.70.83.21.0-1.11.00.50.70.70.21.80.50.5-0.80.8
Locomotion velocity, session 81.01.25.11.4-1.41.20.61.00.90.32.30.60.6-0.90.6
Locomotion distance, session 80.20.21.10.8-0.60.50.40.50.20.21.00.30.2-0.2-0.0
Degree of sensitization distance0.30.30.5-0.60.6-0.6-0.7-0.7-0.6-0.7-0.30.60.6-0.50.1
Degree of sensitization stereotypy1.71.83.0-1.10.8-1.0-1.4-1.3-1.1-1.60.31.71.7-1.71.6
Conditioned locomotion1.41.63.8-1.71.9-1.7-1.2-1.3-1.4-0.9-1.90.10.10.20.8
Cocaine response after cond. corrected4.35.19.6-3.13.0-2.9-2.5-2.7-2.3-2.1-2.90.91.0-0.71.0
Cocaine response after cond. not corrected4.75.510.3-3.23.1-2.9-2.5-2.8-2.4-2.2-3.00.91.0-0.61.1
Cocaine response before conditioning0.40.50.90.8-0.91.00.80.80.90.70.7-0.4-0.40.2-0.4
Saline control response0.20.20.7-0.70.7-0.6-0.3-0.5-0.5-0.2-0.8-0.1-0.10.3-0.1
Bone: connectivity density0.71.12.90.2-0.20.0-0.7-0.4-0.3-1.01.41.51.5-1.71.3
Bone: cortical apparent density0.70.91.3-1.01.0-1.0-1.1-1.0-1.0-1.1-0.31.01.0-0.90.9
Bone: cortical area0.50.82.6-0.1-0.1-0.1-0.8-0.5-0.2-1.00.81.31.3-1.60.8
Bone: cortical porosity0.30.31.00.7-0.70.70.30.50.50.21.00.30.2-0.3-0.1
Bone: cortical porosity0.40.52.00.7-0.60.5-0.00.30.2-0.21.40.90.8-0.90.4
Bone: cortical thickness0.81.42.6-0.70.7-0.9-1.4-1.1-1.0-1.50.31.61.6-1.61.1
Bone: cortical thickness0.30.41.3-0.40.2-0.10.20.10.30.4-1.1-0.9-0.80.8-0.7
Bone: cortical tissue density0.50.60.8-0.80.8-0.8-0.9-0.8-0.8-0.9-0.20.80.8-0.80.8
Condit. Reinf. active minus inactive responses3.33.75.62.4-2.22.12.22.22.12.11.1-1.7-1.81.5-1.3
Condit. Reinf. active-inactive response ratio1.92.13.01.3-1.21.31.61.41.51.6-0.1-1.7-1.71.6-1.5
Condit. Reinf. active responses2.93.67.42.7-2.42.32.22.21.91.92.1-1.0-1.10.8-0.8
Condit. Reinf. inactive responses1.01.24.31.7-1.51.20.91.10.80.62.10.30.2-0.4-0.4
Incentive salience index mean1.92.35.52.3-1.91.81.71.71.51.41.7-0.8-0.80.6-0.7
Condit. Reinf. lever presses0.71.04.31.3-0.90.50.10.30.1-0.32.11.21.1-1.20.6
Condit. Reinf. active minus inactive responses2.32.94.51.2-1.31.51.81.61.81.9-0.3-2.1-2.12.0-2.0
Condit. Reinf. active-inactive response ratio0.60.71.9-0.20.4-0.20.40.1-0.00.6-1.3-1.2-1.11.4-0.9
Condit. Reinf. active responses2.23.14.61.5-1.81.91.81.82.11.90.3-1.8-1.81.5-2.0
Condit. Reinf. inactive responses1.11.53.11.1-1.51.51.21.41.81.20.7-1.0-0.90.5-1.2
Condit. Reinf. lever presses1.82.43.41.1-1.31.41.71.61.71.8-0.1-1.9-1.81.7-1.8
Condit. Reinf. lever reinforcers received1.72.43.61.1-1.41.51.61.51.91.7-0.2-1.8-1.81.5-1.9
Conditioned reinforcement - actives1.11.83.30.4-0.80.91.31.21.21.5-0.7-1.8-1.71.7-1.8
Conditioned reinforcement - inactives0.10.20.6-0.50.4-0.4-0.1-0.3-0.2-0.0-0.8-0.4-0.30.4-0.1
Conditioned locomotion6.88.812.52.9-3.33.23.33.23.33.11.4-2.6-2.72.4-3.5
Patch foraging indifference point 0 sec0.10.30.6-0.30.3-0.3-0.5-0.4-0.4-0.50.20.70.7-0.80.6
Patch foraging indifference point AUC0.81.22.41.1-1.00.91.21.00.91.20.1-1.2-1.21.2-1.6
Delay disc. indifference point, 0s delay7.68.313.0-2.22.2-2.5-3.0-2.8-2.8-3.30.63.63.6-3.53.2
Delay disc. indifference point, 16s delay0.20.20.3-0.50.2-0.3-0.4-0.4-0.2-0.50.00.40.4-0.50.5
Delay disc. indifference point, 2s delay5.56.18.0-2.52.3-2.4-2.8-2.6-2.4-2.8-0.32.72.8-2.72.5
Delay disc. indifference point, 24s delay0.40.40.8-0.90.7-0.7-0.8-0.8-0.5-0.7-0.80.30.4-0.2-0.3
Delay disc. indifference point, 4s delay1.41.42.7-1.30.7-0.7-1.3-1.1-0.7-1.40.21.41.4-1.61.6
Delay disc. indifference point, 8s delay0.91.02.1-1.41.2-1.2-1.2-1.2-0.9-1.1-1.20.60.6-0.50.3
Indifference point function ln k0.10.20.6-0.70.4-0.3-0.5-0.4-0.1-0.4-0.50.20.2-0.30.2
Indifference point function log k0.10.20.6-0.70.4-0.3-0.5-0.4-0.1-0.4-0.50.20.2-0.30.2
Patch foraging total patch changes 0 sec0.10.20.4-0.30.2-0.3-0.5-0.4-0.3-0.50.20.60.6-0.60.5
Patch foraging total patch changes 12 sec0.40.51.1-0.91.0-1.1-0.6-0.9-1.0-0.5-1.10.10.10.10.0
Patch foraging total patch changes 18 sec0.61.01.61.3-1.21.11.11.11.01.10.7-0.8-0.80.7-0.8
Patch foraging total patch changes 24 sec0.00.10.20.5-0.30.20.30.30.10.30.3-0.1-0.10.1-0.2
Patch foraging total patch changes 6 sec0.20.30.90.9-0.70.60.50.60.50.50.7-0.1-0.20.1-0.1
Patch foraging time to switch 0 sec1.53.06.5-0.51.0-1.1-1.5-1.2-1.7-1.71.32.42.3-2.22.6
Patch foraging water rate 0 sec0.51.24.2-0.90.3-0.30.2-0.10.40.5-2.0-1.4-1.31.4-1.7
Patch foraging water rate 12 sec0.91.86.3-2.01.8-1.6-1.1-1.4-1.1-0.8-2.5-0.3-0.20.5-0.2
Patch foraging water rate 18 sec1.82.89.7-1.30.9-0.60.4-0.10.20.9-3.1-2.3-2.22.5-2.0
Patch foraging water rate 24 sec1.72.410.6-2.21.6-1.4-0.5-1.0-0.7-0.0-3.3-1.4-1.31.7-1.2
Patch foraging water rate 6 sec1.21.73.7-0.40.10.10.70.40.71.1-1.9-1.9-1.81.9-1.9
Seeking ratio, delayed vs. immediate footshock3.54.36.62.3-2.62.52.32.32.42.11.6-1.5-1.51.2-2.1
Distance traveled before self-admin0.10.20.6-0.3-0.0-0.1-0.4-0.4-0.1-0.60.20.50.6-0.4-0.7
Distance traveled after self-admin0.10.11.10.2-0.30.20.20.10.30.10.1-0.1-0.00.1-1.1
Extensor digitorum longus weight3.513.621.6-4.74.5-4.5-4.2-4.4-4.2-3.9-3.42.52.6-1.82.1
Bone: elastic displacement0.10.20.30.5-0.40.50.50.50.50.40.3-0.3-0.30.3-0.3
Bone: elastic work0.20.30.7-0.40.2-0.2-0.6-0.4-0.1-0.70.10.70.8-0.80.4
Bone: endosteal estimation0.20.40.9-0.40.1-0.3-0.7-0.5-0.3-0.70.20.80.8-1.00.8
Bone: endosteal perimeter0.30.71.71.0-1.31.10.70.91.10.51.1-0.1-0.1-0.3-0.2
Epididymis fat weight0.10.52.1-0.60.7-0.6-0.0-0.4-0.40.1-1.5-0.8-0.80.90.2
Delta time in closed arm before/after self-admin1.91.77.2-1.91.5-1.4-0.6-1.0-0.9-0.2-2.7-0.9-0.81.2-0.8
Delta time in open arm before/after self-admin0.50.50.9-0.40.7-0.8-0.8-0.8-0.8-0.9-0.20.70.7-0.60.8
Diff in mean of infusions in LGA sessions1.11.32.01.4-1.21.41.41.31.21.20.8-1.0-1.11.0-0.6
Delay discount exponential model param1.41.52.81.7-1.21.21.51.41.01.50.6-1.1-1.21.2-0.9
Extinction: sum of active levers before priming1.01.13.00.4-0.60.71.10.80.71.2-0.4-1.3-1.31.5-1.7
Active lever presses in extinction session 62.32.34.21.6-1.81.71.61.61.71.51.0-1.1-1.11.0-2.0
Bone: final force1.11.74.1-0.80.5-0.8-1.5-1.2-0.8-1.60.41.81.8-2.01.2
Bone: final moment0.91.43.5-0.60.4-0.7-1.4-1.0-0.7-1.50.41.71.7-1.91.1
Food consumed during 24 hour testing period0.40.51.6-1.20.8-0.8-0.8-0.9-0.6-0.8-0.70.50.5-0.50.3
Glucose1.93.14.4-2.12.0-2.0-2.1-2.1-1.8-2.0-1.31.41.5-1.30.9
Heart weight0.71.12.60.4-0.30.50.90.70.81.1-1.0-1.6-1.61.6-1.2
Delay discount hyperbolic model param2.52.74.22.0-1.51.61.91.81.42.00.6-1.7-1.71.7-1.4
Intermittent access intake day 1-15 change3.16.49.62.1-2.22.42.72.62.62.90.1-2.8-2.82.7-3.1
Intermittent access intake escalation2.75.68.22.0-2.02.22.62.42.52.70.1-2.7-2.72.5-2.9
Intermittent access intake escalation 24.34.96.52.1-2.02.12.42.32.32.50.2-2.4-2.42.2-2.5
Intermitt. access day 1 inactive lever presses0.41.35.4-0.40.1-0.10.50.10.50.7-1.7-1.5-1.41.6-2.3
Intermitt. access day 15 inactive lever presses0.20.30.50.7-0.70.70.70.70.60.60.4-0.4-0.50.3-0.2
Intermitt. access escalation Index0.71.02.4-0.30.4-0.5-1.0-0.7-0.7-1.10.81.51.5-1.61.1
Intermittent access day 1 total infusions0.20.30.8-0.3-0.10.10.40.20.40.4-0.8-0.9-0.90.8-0.6
Intermittent access day 15 total infusions2.33.44.81.3-1.71.82.01.92.12.0-0.0-2.2-2.11.9-2.2
Intermittent access terminal intake (last 3 days)1.82.44.01.1-1.41.51.61.51.81.60.0-1.7-1.71.5-2.0
Intermittent access total infusions1.01.22.00.4-0.91.01.11.01.21.1-0.2-1.3-1.31.2-1.4
Intermittent access day 1 locomotion1.41.83.70.5-0.80.91.41.11.21.5-0.7-1.9-1.91.9-1.5
Intermittent access day 15 total locomotion2.74.96.81.8-1.92.02.52.22.22.5-0.0-2.6-2.62.6-2.5
Intermittent access total locomotion2.32.84.81.0-1.41.41.81.51.61.8-0.2-2.0-2.02.0-2.2
Intermittent access standard deviation3.47.09.42.6-2.92.92.92.83.12.81.0-2.5-2.52.2-2.9
Left kidney weight0.10.41.8-0.50.6-0.4-0.1-0.2-0.10.2-1.3-0.7-0.70.8-0.8
Right kidney weight0.52.14.10.9-0.81.11.41.31.51.6-0.8-2.0-2.01.8-1.6
Cocaine induced anxiety1.11.53.91.9-1.61.51.21.41.21.02.0-0.1-0.2-0.0-0.5
Post-drug Anxiety1.31.44.51.9-1.61.41.11.21.00.72.10.10.0-0.30.1
Baseline Anxiety0.10.10.20.1-0.30.30.30.20.40.1-0.1-0.3-0.30.2-0.4
Tail length3.011.916.03.2-3.53.83.83.94.03.81.1-3.4-3.42.9-3.7
Length with tail1.67.19.02.7-2.62.93.03.02.93.00.9-2.6-2.72.4-2.7
Length without tail0.00.00.1-0.10.1-0.2-0.1-0.1-0.1-0.1-0.2-0.0-0.00.0-0.0
Times rat made contact with spout0.30.31.2-0.80.7-0.6-0.4-0.5-0.4-0.2-1.1-0.2-0.20.3-0.1
Lifetime Intake0.50.71.30.2-0.60.60.80.60.90.8-0.4-1.1-1.01.0-1.1
Liver weight, left0.81.42.0-1.31.4-1.4-1.3-1.4-1.3-1.3-0.90.80.9-0.71.1
Liver weight, right0.50.81.5-1.21.0-1.1-1.0-1.2-0.8-0.9-1.20.30.4-0.40.1
Locomotor activity3.04.88.12.8-2.82.82.22.52.62.02.3-1.0-1.00.6-1.9
Locomotor testing distance1.73.05.32.2-2.32.21.82.02.01.61.9-0.8-0.80.4-1.6
Locomotor testing rearing0.10.20.4-0.2-0.00.10.20.20.40.3-0.6-0.6-0.60.4-0.5
Locomotion in novel chamber1.21.54.50.9-0.90.91.31.10.91.3-0.1-1.3-1.31.5-2.1
Locomotion in novel chamber post-restriction1.01.62.50.9-1.21.41.31.41.61.40.2-1.4-1.31.0-1.2
Fecal boli incidents, locomotor time 11.11.63.5-1.11.7-1.7-1.4-1.5-1.9-1.3-1.01.01.0-0.40.4
Change in fecal boli incidents, locomotor task0.60.61.80.5-1.11.10.50.81.30.40.8-0.1-0.0-0.5-0.9
Time >=10cm from walls, locomotor time 10.40.51.30.30.0-0.2-0.6-0.3-0.2-0.60.81.11.1-1.1-0.4
Bouts of movement, locomotor time 10.30.40.50.5-0.50.60.60.60.70.7-0.1-0.7-0.70.6-0.7
Total resting periods, locomotor time 10.40.50.70.7-0.70.70.70.70.80.70.1-0.7-0.70.6-0.7
Rest time, locomotor task time 10.20.20.40.6-0.60.60.50.60.50.40.6-0.2-0.20.0-0.2
Distance moved, locomotor task time 10.60.92.5-0.40.2-0.3-0.9-0.6-0.3-1.00.81.41.4-1.60.6
Vertical activity count, locomotor time 10.10.20.5-0.70.3-0.3-0.5-0.40.1-0.3-0.70.00.1-0.2-0.4
Time >=10cm from walls, locomotor time 20.60.91.6-1.11.2-1.2-1.1-1.2-0.9-0.9-1.30.50.6-0.3-0.5
Bouts of movement, locomotor time 20.30.52.01.2-0.90.80.50.60.50.31.40.30.2-0.40.6
Total resting periods, locomotor time 20.30.62.21.2-0.90.80.50.60.50.31.50.40.3-0.50.8
Rest time, locomotor task time 20.50.71.21.1-1.11.10.81.00.90.71.1-0.2-0.30.1-0.3
Distance moved, locomotor task time 20.60.71.3-1.11.0-1.0-0.8-1.0-1.0-0.7-0.90.40.4-0.20.5
Vertical activity count, locomotor time 20.60.82.4-1.31.2-1.1-0.7-0.9-0.9-0.5-1.6-0.1-0.10.3-0.1
Light reinforcement 13.48.313.13.6-3.43.43.33.43.03.12.5-2.0-2.11.8-2.2
Light reinforcement 21.42.23.61.9-1.81.81.71.81.61.51.5-0.9-1.00.8-0.8
Bone: marrow area0.20.40.9-0.40.2-0.3-0.7-0.5-0.4-0.70.20.80.8-1.00.8
Bone: maximum diameter0.91.73.71.8-1.91.81.21.51.61.01.8-0.3-0.3-0.2-0.6
Bone: maximum force1.01.73.4-1.00.7-0.9-1.6-1.3-0.9-1.60.11.61.7-1.81.2
Bone: maximum moment0.81.43.0-0.90.6-0.8-1.4-1.1-0.8-1.50.11.51.6-1.71.1
Mean time between licks in bursts2.15.26.82.3-2.32.42.62.52.32.60.9-2.3-2.32.1-2.1
Mean num. licks in bursts0.10.10.30.1-0.0-0.0-0.2-0.1-0.1-0.30.40.50.5-0.60.4
Cd content in liver0.10.20.30.4-0.50.50.50.50.40.40.5-0.2-0.20.2-0.3
Co content in liver1.51.72.31.3-1.21.31.51.41.31.50.2-1.4-1.41.4-1.3
Cu content in liver0.40.51.80.8-1.00.80.40.60.70.21.40.40.3-0.5-0.1
Fe content in liver0.10.20.4-0.1-0.10.20.40.30.20.5-0.3-0.6-0.60.7-0.4
K content in liver0.30.31.20.8-0.60.40.10.20.2-0.11.10.60.5-0.50.1
Mg content in liver0.30.30.91.0-0.80.70.50.60.60.50.8-0.1-0.10.1-0.4
Mn content in liver2.02.26.51.9-2.22.01.11.61.70.82.60.20.2-0.7-0.2
Na content in liver1.11.12.5-0.20.4-0.6-1.0-0.9-1.0-1.20.81.61.5-1.41.2
Rb content in liver0.50.52.20.9-0.80.60.00.30.3-0.21.50.80.8-1.00.4
Se content in liver0.10.20.30.3-0.30.40.50.50.40.50.1-0.5-0.50.5-0.2
Sr content in liver0.10.10.3-0.30.3-0.2-0.1-0.2-0.20.0-0.5-0.2-0.20.3-0.1
Zn content in liver4.14.68.71.3-1.21.42.21.81.72.4-0.9-2.9-2.93.0-2.6
Bone: minimum diameter0.10.20.70.3-0.50.3-0.20.10.3-0.30.70.60.6-0.80.3
Time in familiar zone, hab. session 11.81.72.61.1-1.11.31.51.41.51.50.0-1.6-1.61.3-0.7
Time in novel zone, hab. session 11.01.02.3-0.70.4-0.6-1.1-0.8-0.7-1.20.61.51.5-1.50.5
Total zone transitions, hab. session 10.91.35.01.6-1.51.41.01.20.90.72.20.30.2-0.40.4
Total locomotion distance, hab. session 11.62.38.82.0-2.01.81.11.41.30.73.00.60.5-0.90.7
Locomotion velocity, hab. session 11.72.48.02.3-2.01.81.41.61.31.02.80.20.1-0.40.4
Time in familiar zone, hab. session 25.55.88.32.1-2.02.32.72.52.52.80.0-2.9-2.92.6-2.4
Time in novel zone, hab. session 24.24.26.4-1.81.5-1.8-2.3-2.1-1.9-2.40.12.52.5-2.42.1
Total zone transitions, hab. session 21.41.85.40.6-0.3-0.1-0.5-0.3-0.8-0.92.32.01.9-1.82.0
Total locomotion distance, hab. session 21.11.45.32.0-1.41.31.11.20.70.72.30.30.1-0.30.8
Locomotion velocity, hab. session 21.31.77.32.1-1.51.31.01.20.70.62.70.50.4-0.50.9
Novel to familiar place preference ratio3.63.96.9-1.61.3-1.6-2.2-2.0-1.8-2.40.52.62.6-2.51.5
Novelty place preference2.32.44.7-1.20.9-1.2-1.7-1.5-1.3-1.90.62.22.2-2.11.1
Time in novel zone, NPP test2.52.74.8-1.31.1-1.3-1.8-1.6-1.4-2.00.42.22.2-2.11.2
Total zone transitions, NPP test0.60.82.80.8-0.20.0-0.1-0.0-0.6-0.41.71.21.1-0.91.5
Total locomotion distance, NPP test0.60.93.00.8-0.30.1-0.2-0.0-0.4-0.51.71.21.1-1.11.5
Locomotion velocity, NPP test0.60.83.41.1-0.60.40.20.3-0.1-0.21.91.00.9-0.91.2
Intraocular pressure0.71.03.9-0.90.9-0.70.1-0.3-0.40.4-2.0-1.2-1.21.5-0.8
Delta distance traveled before/after self-admin0.30.30.70.7-0.40.50.60.70.50.90.0-0.7-0.70.6-0.3
Delta ambulatory time before/after self-admin0.20.30.70.7-0.50.60.60.70.50.80.3-0.5-0.50.3-0.0
Parametrial fat weight0.00.10.30.0-0.20.1-0.00.0-0.1-0.10.50.30.3-0.4-0.2
Pavlov. Cond. lever latency0.60.72.6-0.80.6-0.40.1-0.1-0.10.3-1.6-1.0-0.91.1-1.2
Pavlov. Cond. magazine entry latency2.32.94.42.1-1.81.82.01.91.72.01.0-1.6-1.61.4-1.1
Pavlov. Cond. change in total contacts0.00.00.20.4-0.20.20.20.20.10.20.3-0.0-0.00.00.1
Pavlov. Cond. index score0.40.51.41.2-0.90.80.70.70.60.51.1-0.1-0.1-0.10.3
Pavlov. Cond. latency score0.50.72.21.3-1.10.90.60.70.60.41.50.20.2-0.40.6
Pavlov. Cond. lever contacts0.50.61.90.7-0.50.3-0.10.00.0-0.31.40.90.9-1.01.1
Pavlov. Cond. magazine entry number0.50.71.1-1.10.8-0.9-1.0-0.9-0.7-1.0-0.40.80.9-0.80.2
Pavlov. Cond. intertrial magazine entries0.30.41.0-0.00.10.10.40.30.20.6-0.8-1.0-0.91.0-0.5
Pavlov. Cond. lever-magazine prob. diff.0.50.61.61.3-1.00.90.80.80.70.61.1-0.2-0.30.10.1
Pavlov. Cond. response bias0.60.71.31.1-0.90.91.00.90.81.00.5-0.8-0.80.6-0.3
Pavlov. Cond. lever latency0.81.12.3-0.81.2-1.2-1.0-1.2-1.5-1.1-0.21.01.0-0.71.3
Pavlov. Cond. magazine entry latency0.50.51.20.5-1.00.90.70.81.10.70.3-0.6-0.60.3-0.9
Pavlov. Cond. change in total contacts0.61.01.80.6-0.91.00.91.01.31.0-0.1-1.1-1.10.9-1.3
Pavlov. Cond. index score0.81.02.00.7-1.11.10.91.01.41.00.1-1.0-1.00.7-1.4
Pavlov. Cond. latency score0.81.02.20.8-1.21.20.91.11.51.00.3-0.9-0.90.6-1.3
Pavlov. Cond. lever contacts0.70.91.90.5-0.91.00.91.01.31.0-0.2-1.1-1.00.8-1.4
Pavlov. Cond. magazine entry number0.70.92.0-0.71.3-1.2-0.9-1.0-1.4-0.9-0.40.80.8-0.41.1
Pavlov. Cond. intertrial magazine entries0.30.40.9-0.80.9-0.9-0.6-0.7-0.7-0.5-0.90.10.10.10.2
Pavlov. Cond. lever-magazine prob. diff.0.81.02.20.8-1.21.21.01.11.51.00.3-0.9-0.90.6-1.3
Pavlov. Cond. response bias1.72.33.71.0-1.41.51.51.61.91.6-0.1-1.7-1.61.3-1.9
Time in closed arm before self-admin0.70.91.9-0.00.3-0.4-0.7-0.6-0.7-0.91.01.41.3-1.41.3
Time in closed arm after self-admin0.20.20.5-0.00.10.10.40.30.20.5-0.5-0.7-0.70.7-0.3
Time in open arm before self-admin0.30.31.50.2-0.60.50.50.50.60.60.2-0.3-0.30.4-1.2
Time in open arm after self-admin0.70.71.1-1.00.9-1.0-1.0-1.0-0.9-1.0-0.50.80.8-0.60.4
Bone: periosteal estimation0.40.82.50.0-0.2-0.0-0.7-0.4-0.1-0.91.01.31.3-1.60.9
Bone: periosteal perimeter0.30.61.70.9-1.10.90.30.60.90.11.30.40.4-0.80.0
Bone: post-yield work0.50.71.0-1.00.8-0.9-1.0-1.0-0.8-1.0-0.70.70.7-0.70.8
Progressive ratio test 1 active lever presses0.30.41.4-0.60.2-0.10.30.00.20.4-1.2-1.0-0.90.9-0.3
Progressive ratio test 1 breakpoint0.30.41.4-0.60.3-0.10.2-0.00.20.3-1.2-1.0-0.90.9-0.4
Progressive ratio test 1 inactive lever presses0.20.30.80.1-0.20.30.60.40.50.6-0.4-0.9-0.90.8-0.5
Progressive ratio test 2 active lever presses0.91.02.7-0.4-0.10.10.60.30.60.7-1.4-1.4-1.41.5-1.6
Progressive ratio test 2 breakpoint0.91.12.7-0.3-0.20.20.70.30.70.8-1.4-1.5-1.41.5-1.7
Progressive ratio test 2 inactive lever presses0.10.20.70.1-0.40.30.40.30.40.4-0.2-0.5-0.50.5-0.9
Incentive Sensitization - Responses0.50.72.4-0.70.5-0.50.0-0.3-0.10.2-1.5-0.9-0.81.1-1.4
Incentive Sensitization - Breakpoint0.40.61.8-0.50.3-0.30.2-0.1-0.00.3-1.3-0.9-0.81.1-1.3
Sum of active levers in priming session hrs 5-60.00.00.3-0.10.2-0.1-0.1-0.1-0.1-0.0-0.10.00.10.1-0.6
Progressive ratio0.40.71.8-0.61.2-1.2-0.6-0.9-1.3-0.5-0.90.10.10.40.8
Food seeking constrained by brief footshock0.10.10.40.6-0.20.20.40.2-0.30.30.5-0.1-0.10.30.5
Seeking ratio, punishment vs. effort0.30.41.10.8-0.90.90.60.70.70.41.0-0.0-0.1-0.2-0.1
Retroperitoneal fat weight0.52.14.3-1.82.1-1.9-1.3-1.7-1.9-1.2-1.90.30.40.10.8
Reaction time number correct0.61.14.1-1.81.4-1.1-0.7-0.9-0.7-0.4-2.0-0.5-0.40.50.1
Reaction time mean minus median0.30.81.50.8-1.00.90.90.91.20.90.0-1.0-0.90.7-1.2
Reaction time mean minus median AUC0.10.30.90.5-0.70.5-0.10.20.5-0.30.90.60.6-1.00.0
Reaction time num false alarms0.20.31.7-0.90.5-0.4-0.4-0.40.1-0.2-1.3-0.5-0.40.3-0.4
Reaction time num false alarms AUC0.30.52.4-1.10.7-0.5-0.4-0.5-0.0-0.2-1.5-0.6-0.50.5-0.5
Reaction time trials correct on left0.61.14.1-1.81.4-1.1-0.7-0.9-0.7-0.4-2.0-0.5-0.40.50.1
Reaction time trials on left0.61.13.8-1.71.4-1.1-0.7-0.9-0.7-0.5-1.9-0.4-0.30.50.1
Reaction time mean0.10.20.70.4-0.40.2-0.20.00.3-0.30.60.50.5-0.80.3
Reaction time mean AUC0.10.20.80.4-0.30.2-0.3-0.00.2-0.30.60.60.6-0.90.3
Median of all reaction times0.30.51.60.10.0-0.2-0.6-0.4-0.2-0.70.61.01.0-1.30.9
Reaction time omissions0.20.31.00.8-0.60.60.40.50.40.21.00.20.2-0.2-0.3
Reaction time false alarm rate0.00.00.1-0.20.1-0.1-0.2-0.10.2-0.2-0.20.00.1-0.1-0.2
Reaction time premature initiation rate0.91.22.00.8-0.81.01.21.11.11.3-0.2-1.4-1.41.4-1.1
Reaction time premature initiations0.71.33.2-0.1-0.10.50.90.70.81.2-1.3-1.8-1.71.8-1.2
Std. dev. reaction times0.10.30.60.7-0.70.60.40.50.80.40.3-0.3-0.30.0-0.6
Reaction time trials completed0.61.13.8-1.71.4-1.1-0.7-0.9-0.7-0.5-1.9-0.4-0.30.50.1
Reaction time trials AUC0.61.24.8-1.81.4-1.2-0.7-1.0-0.7-0.4-2.2-0.6-0.50.70.0
Run reversals in cocaine runway, females0.60.61.31.0-1.11.00.70.80.90.51.1-0.2-0.2-0.1-0.2
Run reversals in cocaine runway, males1.31.32.51.6-1.41.51.31.41.31.11.3-0.6-0.70.3-0.2
Latency to leave start box in cocaine runway0.91.02.51.3-1.61.20.70.91.20.41.60.10.1-0.4-1.2
Latency to leave start box in cocaine runway, F0.80.93.20.8-1.10.6-0.10.10.5-0.51.81.11.1-1.4-0.7
Latency to leave start box in cocaine runway, M1.81.72.31.0-1.11.11.41.31.31.5-0.0-1.5-1.51.5-1.4
Std. dev. time between licks in bursts0.81.12.51.2-1.41.51.01.21.60.81.1-0.4-0.40.0-0.6
Total sessions with >9 infusions0.50.61.8-0.1-0.30.40.60.40.70.6-0.7-1.0-0.90.9-1.3
Short access day 1 total inactive lever presses0.20.30.60.4-0.30.30.60.50.40.7-0.2-0.8-0.70.8-0.4
Short access day 10 total inactive lever presses0.20.42.0-0.30.3-0.30.1-0.1-0.10.2-1.0-0.6-0.60.9-1.4
Short access day 1 total infusions0.20.30.40.4-0.40.50.60.60.50.60.0-0.6-0.60.5-0.3
Short access day 10 total infusions0.20.20.7-0.40.1-0.10.3-0.00.20.2-0.9-0.8-0.70.7-0.4
Short access total infusions0.30.41.00.1-0.40.40.60.40.60.6-0.4-0.9-0.90.9-1.0
Short access day 1 locomotion1.31.62.60.9-1.21.31.41.31.51.40.1-1.4-1.41.2-1.6
Short access day 10 total locomotion4.17.512.21.9-2.12.32.92.62.73.0-0.5-3.4-3.33.3-3.5
Short access total locomotion2.42.96.01.0-1.41.51.81.61.81.8-0.2-2.0-1.91.9-2.5
One hour access (0.3 mA shock)0.10.10.3-0.50.1-0.2-0.1-0.20.0-0.1-0.5-0.3-0.20.20.1
Compulsive drug intake1.21.43.2-0.40.3-0.6-1.1-0.9-0.9-1.41.01.81.8-1.71.0
One hour access (shock baseline)0.50.71.80.0-0.30.40.80.60.80.9-0.8-1.3-1.31.2-0.4
Social response proportion0.60.72.01.4-0.91.00.91.00.60.81.2-0.3-0.30.30.4
Social responses5.97.611.33.3-3.33.43.13.33.22.92.2-2.0-2.11.5-2.0
Social time0.50.61.5-0.71.1-1.0-0.7-0.8-1.2-0.7-0.40.60.6-0.30.7
Soleus weight6.719.826.9-4.94.8-4.9-5.2-5.1-4.8-5.0-2.44.04.1-3.63.8
Bone: stiffness2.13.45.1-1.71.5-1.6-2.2-1.9-1.7-2.3-0.32.12.2-2.11.8
Tibialis anterior weight0.82.84.1-2.01.7-1.9-2.0-2.0-1.8-2.0-1.11.51.5-1.30.8
Time to tail flick, vehicle, before self-admin0.10.10.30.5-0.50.30.20.30.30.10.60.10.1-0.1-0.4
Time to tail flick, vehicle, after self-admin0.50.72.0-0.10.30.00.60.30.20.6-1.3-1.4-1.41.4-0.2
Time to tail flick, test, before self-admin0.40.41.21.0-0.80.90.50.70.70.51.10.10.1-0.30.1
Time to tail flick, test, after self-admin0.10.10.10.3-0.20.30.30.30.20.20.2-0.2-0.20.10.3
Delta time to tail flick, vehicle, before/after SA0.80.83.1-1.11.2-0.9-0.4-0.6-0.7-0.3-1.8-0.7-0.60.80.5
Delta time to tail flick, test, before/after SA0.30.31.4-0.50.5-0.40.0-0.2-0.30.2-1.2-0.7-0.70.8-0.1
Tibia length0.71.92.61.3-1.31.51.61.61.61.60.4-1.5-1.51.3-1.0
Ambulatory time before self-admin0.10.20.7-0.30.0-0.2-0.3-0.4-0.1-0.60.10.50.5-0.3-0.8
Ambulatory time after self-admin0.10.10.70.2-0.30.10.00.10.20.00.20.10.1-0.0-0.9
Bone: tissue strength1.61.62.2-1.01.1-1.3-1.4-1.4-1.4-1.5-0.21.51.5-1.31.2
Total heroin consumption1.21.52.11.4-1.41.41.41.31.31.21.0-0.9-0.90.8-1.1
Bone: trabecular number0.60.93.01.3-1.41.20.71.01.00.41.70.30.2-0.60.0
Bone: trabecular spacing1.21.66.9-1.71.6-1.4-0.5-1.0-0.9-0.1-2.6-1.0-0.91.2-0.4
Bone: trabecular thickness2.12.69.51.5-1.41.1-0.30.40.6-0.73.12.12.0-2.41.0
Bone: trabecular tissue density1.21.73.2-1.41.8-1.7-1.4-1.6-1.8-1.3-1.10.90.9-0.41.0
Water consumed over 24 hours0.60.81.6-0.90.5-0.6-1.0-0.8-0.6-1.10.21.11.2-1.20.7
Number of responses in last shaping day1.71.83.20.7-1.11.11.41.21.51.4-0.4-1.7-1.71.5-1.8