Hub : Genes

Mknk2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Mknk2 0.1 0.07 3.8e-08 0.06 0.06 0.06 0.06 1.7e-06 4.1e-06 2.4e-06 1.2e-06
2 Liver gene expression Mknk2 0.08 0.06 3.2e-04 0.03 0.01 0.02 0.02 7.3e-04 8.3e-03 1.1e-03 2.2e-03
3 BLA gene expression Mknk2 0.45 0.21 1.7e-07 0.14 0.12 0.14 0.14 4.4e-08 3.3e-07 6.6e-08 4.8e-08
4 IL gene expression Mknk2 0.13 0.1 5.1e-03 0.05 0.06 0.04 0.04 2.5e-02 1.2e-02 3.3e-02 3.0e-02
5 PL gene expression Mknk2 0.29 0.22 3.8e-11 0.08 0.1 0.08 0.09 3.8e-09 3.4e-11 2.8e-09 2.7e-10
6 NAcc gene expression Mknk2 0.07 0.05 1.2e-08 0.06 0.07 0.07 0.07 1.3e-07 1.1e-08 9.3e-09 5.6e-09
7 Adipose gene expression Mknk2 0.1 0.07 6.0e-10 0.07 0.08 0.08 0.07 1.6e-08 3.7e-09 5.1e-09 1.0e-08
8 Adipose mRNA stability Mknk2 0.06 0.04 2.5e-05 0 0.03 0.03 0.02 7.6e-02 3.9e-04 4.0e-04 2.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.61.02.80.51.1-1.1-0.30.2-0.71.51.7
Area under the delay curve2.22.33.1-1.7-1.21.3-1.7-1.3-1.71.51.5
BMI with tail6.220.024.3-4.9-4.74.9-4.7-4.8-4.53.63.4
BMI without tail2.24.67.7-2.8-2.62.7-2.3-2.2-1.91.00.8
Body weight1.04.45.5-2.4-2.12.3-2.3-2.2-2.11.71.6
Weight adjusted by age0.40.41.1-0.9-1.00.9-0.5-0.5-0.3-0.3-0.4
Bone surface1.32.34.81.32.2-2.10.20.9-0.31.71.9
Bone volume1.32.34.81.32.2-2.10.21.0-0.31.61.9
Breakpoint value in progressive ratio session5.15.66.82.12.0-2.12.62.42.6-2.6-2.5
Number of licking bursts0.20.30.5-0.6-0.60.6-0.1-0.20.2-0.6-0.7
Context. condit. distance diff. score0.20.30.4-0.6-0.60.6-0.6-0.5-0.60.30.3
Locomotion velocity, session 10.70.71.61.31.2-1.20.70.80.50.10.3
Locomotion distance, session 10.50.71.51.10.9-0.90.20.0-0.11.01.2
Locomotion velocity, session 23.33.87.72.82.5-2.52.01.81.7-0.5-0.2
Locomotion distance, session 21.62.24.82.22.0-2.01.41.11.00.20.4
Locomotion velocity, session 35.86.87.72.72.5-2.52.82.72.7-2.5-2.4
Locomotion distance, session 30.00.00.1-0.2-0.10.1-0.00.00.0-0.2-0.2
Stereotopy head waving bouts, day 34.35.17.52.72.5-2.52.42.32.2-1.6-1.4
Stereotopy head waving duration, day 35.26.28.62.92.6-2.62.72.52.6-2.0-1.8
Locomotion velocity, session 70.80.92.00.71.1-1.10.81.40.9-0.7-0.8
Locomotion distance, session 70.20.20.5-0.7-0.60.6-0.3-0.1-0.0-0.4-0.5
Stereotopy head waving bouts, day 70.20.30.70.40.6-0.5-0.00.1-0.30.70.8
Stereotopy head waving duration, day 70.40.51.20.91.1-1.00.40.60.10.50.6
Locomotion velocity, session 80.80.92.01.31.4-1.40.60.70.30.50.7
Locomotion distance, session 80.10.20.60.80.6-0.50.30.20.20.20.3
Degree of sensitization distance0.30.30.4-0.6-0.60.5-0.7-0.5-0.60.60.5
Degree of sensitization stereotypy1.82.03.1-1.3-0.80.9-1.5-1.2-1.71.81.8
Conditioned locomotion1.51.83.9-1.6-2.01.8-1.3-1.4-1.00.30.2
Cocaine response after cond. corrected4.75.38.8-3.0-2.92.9-2.4-2.3-2.01.00.8
Cocaine response after cond. not corrected5.15.79.5-3.0-3.13.0-2.5-2.3-2.01.00.7
Cocaine response before conditioning0.50.60.90.90.9-0.90.70.90.6-0.5-0.4
Saline control response0.10.10.2-0.2-0.40.4-0.2-0.3-0.10.00.0
Bone: connectivity density0.60.92.8-0.10.4-0.4-0.7-0.4-1.01.61.7
Bone: cortical apparent density0.70.91.1-1.1-1.01.0-1.0-1.0-1.00.80.8
Bone: cortical area0.60.92.0-0.6-0.00.1-1.0-0.5-1.11.41.4
Bone: cortical porosity0.60.61.21.01.1-1.10.70.90.6-0.2-0.1
Bone: cortical porosity0.30.30.60.60.7-0.70.10.2-0.20.70.8
Bone: cortical thickness1.01.62.3-1.1-0.90.9-1.4-1.2-1.51.51.5
Bone: cortical thickness0.20.20.6-0.3-0.30.40.10.20.3-0.7-0.8
Bone: cortical tissue density0.50.60.8-0.9-0.80.8-0.8-0.9-0.80.60.6
Condit. Reinf. active minus inactive responses3.84.25.02.22.1-2.12.22.12.2-1.8-1.7
Condit. Reinf. active-inactive response ratio2.12.33.01.21.2-1.21.61.51.7-1.7-1.7
Condit. Reinf. active responses3.24.06.32.52.4-2.32.11.91.9-1.2-1.0
Condit. Reinf. inactive responses0.91.02.51.61.4-1.40.90.70.70.10.3
Incentive salience index mean1.92.33.61.91.9-1.81.61.51.4-0.9-0.7
Condit. Reinf. lever presses0.50.71.70.80.9-0.80.0-0.0-0.31.21.3
Condit. Reinf. active minus inactive responses2.42.94.31.31.3-1.31.81.81.9-2.1-2.1
Condit. Reinf. active-inactive response ratio0.40.41.3-0.1-0.40.40.40.10.7-1.1-1.2
Condit. Reinf. active responses2.33.24.41.61.7-1.71.82.11.8-1.8-1.8
Condit. Reinf. inactive responses1.31.62.71.31.5-1.51.11.71.1-0.9-0.9
Condit. Reinf. lever presses2.33.24.21.51.4-1.41.91.92.0-2.1-2.0
Condit. Reinf. lever reinforcers received1.82.53.51.21.3-1.31.61.91.7-1.8-1.8
Conditioned reinforcement - actives2.32.32.91.41.6-1.71.61.71.5-1.3-1.3
Conditioned reinforcement - inactives0.50.51.0-1.0-1.00.9-0.7-0.7-0.60.20.1
Conditioned locomotion7.18.59.72.83.0-3.03.13.13.0-2.7-2.6
Patch foraging indifference point 0 sec0.10.20.4-0.3-0.30.2-0.5-0.4-0.50.60.6
Patch foraging indifference point AUC0.81.01.21.00.9-0.81.10.91.1-1.1-1.0
Delay disc. indifference point, 0s delay7.48.112.7-2.4-2.01.9-2.9-2.7-3.33.53.6
Delay disc. indifference point, 16s delay0.10.10.3-0.5-0.20.4-0.4-0.3-0.40.40.4
Delay disc. indifference point, 2s delay5.76.38.0-2.6-2.22.0-2.7-2.4-2.82.72.6
Delay disc. indifference point, 24s delay0.60.61.0-0.9-0.71.0-0.9-0.7-0.70.50.5
Delay disc. indifference point, 4s delay1.11.21.8-1.2-0.60.7-1.2-0.7-1.31.31.3
Delay disc. indifference point, 8s delay1.01.11.7-1.3-1.21.3-1.2-0.9-1.00.60.5
Indifference point function ln k0.20.30.6-0.8-0.50.4-0.6-0.3-0.50.40.3
Indifference point function log k0.20.30.6-0.8-0.50.4-0.6-0.3-0.50.40.3
Patch foraging total patch changes 0 sec0.10.10.2-0.3-0.30.2-0.4-0.3-0.40.40.4
Patch foraging total patch changes 12 sec0.40.51.2-0.8-1.01.1-0.6-0.9-0.40.0-0.1
Patch foraging total patch changes 18 sec1.01.31.61.21.1-1.11.31.11.2-1.1-1.0
Patch foraging total patch changes 24 sec0.10.10.10.40.3-0.20.30.10.3-0.2-0.2
Patch foraging total patch changes 6 sec0.20.30.70.90.6-0.60.60.50.5-0.3-0.3
Patch foraging time to switch 0 sec1.72.65.4-0.7-1.00.8-1.5-1.7-1.82.22.3
Patch foraging water rate 0 sec0.40.61.9-0.7-0.40.50.10.40.5-1.2-1.4
Patch foraging water rate 12 sec1.01.63.4-1.7-1.81.9-1.1-1.1-0.7-0.1-0.3
Patch foraging water rate 18 sec1.11.54.9-0.7-0.80.90.40.30.9-2.0-2.2
Patch foraging water rate 24 sec1.11.52.9-1.6-1.61.7-0.4-0.60.1-1.2-1.5
Patch foraging water rate 6 sec0.71.13.4-0.1-0.00.10.70.81.1-1.7-1.8
Seeking ratio, delayed vs. immediate footshock4.35.06.82.42.6-2.52.32.42.2-1.6-1.5
Distance traveled before self-admin0.40.40.7-0.6-0.30.4-0.7-0.5-0.70.90.8
Distance traveled after self-admin0.70.71.20.91.1-1.00.91.00.8-0.5-0.5
Extensor digitorum longus weight4.317.123.0-4.8-4.74.7-4.4-4.4-4.12.82.5
Bone: elastic displacement0.20.30.40.60.6-0.70.50.60.5-0.3-0.3
Bone: elastic work0.20.20.5-0.5-0.10.0-0.6-0.1-0.60.70.7
Bone: endosteal estimation0.20.40.7-0.6-0.10.3-0.7-0.5-0.80.90.9
Bone: endosteal perimeter0.30.71.70.81.3-1.20.61.00.5-0.00.0
Epididymis fat weight0.20.40.80.50.1-0.20.70.20.7-0.9-0.9
Delta time in closed arm before/after self-admin1.31.22.5-1.5-1.61.6-0.7-0.9-0.4-0.6-0.8
Delta time in open arm before/after self-admin1.11.11.5-0.7-0.90.9-1.1-1.1-1.11.21.2
Diff in mean of infusions in LGA sessions1.51.72.21.41.2-1.21.51.31.4-1.2-1.2
Delay discount exponential model param1.92.02.91.71.2-1.31.61.21.6-1.4-1.3
Extinction: sum of active levers before priming1.31.22.60.60.6-0.61.20.91.3-1.6-1.6
Active lever presses in extinction session 62.82.73.41.61.8-1.81.81.81.6-1.3-1.3
Bone: final force1.11.83.0-1.1-0.60.8-1.5-1.1-1.61.71.7
Bone: final moment0.91.42.5-1.0-0.50.6-1.4-0.9-1.41.61.5
Food consumed during 24 hour testing period0.50.61.4-1.2-0.80.8-0.8-0.6-0.80.50.4
Glucose1.21.82.5-1.6-1.41.5-1.5-1.4-1.41.11.0
Heart weight0.40.51.20.50.3-0.20.70.60.8-1.1-1.1
Delay discount hyperbolic model param2.72.93.92.01.5-1.51.91.41.9-1.7-1.6
Intermittent access intake day 1-15 change6.86.77.72.52.5-2.42.72.82.8-2.5-2.5
Intermittent access intake escalation6.66.58.82.12.0-2.02.72.62.9-3.0-3.0
Intermittent access intake escalation 28.07.910.42.52.2-2.23.02.83.2-3.2-3.2
Intermitt. access day 1 inactive lever presses0.40.41.20.00.3-0.20.50.70.7-1.0-1.1
Intermitt. access day 15 inactive lever presses0.50.60.80.70.5-0.50.80.80.8-0.9-0.9
Intermitt. access escalation Index0.40.41.2-0.00.1-0.1-0.5-0.3-0.71.01.1
Intermittent access day 1 total infusions0.00.00.1-0.3-0.10.0-0.2-0.1-0.30.30.3
Intermittent access day 15 total infusions2.02.32.91.21.2-1.31.61.61.6-1.7-1.7
Intermittent access terminal intake (last 3 days)1.21.31.70.91.0-1.11.11.31.2-1.1-1.1
Intermittent access total infusions0.20.30.40.20.4-0.50.50.60.5-0.6-0.6
Intermittent access day 1 locomotion0.40.40.40.50.5-0.60.60.60.6-0.7-0.7
Intermittent access day 15 total locomotion3.43.74.31.91.8-1.82.11.92.1-1.9-1.8
Intermittent access total locomotion1.01.11.41.01.2-1.21.11.11.0-0.9-0.9
Intermittent access standard deviation3.13.24.01.51.5-1.51.81.91.9-2.0-2.0
Left kidney weight0.10.20.40.50.6-0.60.20.30.10.30.4
Right kidney weight1.43.85.02.22.0-2.12.02.11.9-1.5-1.4
Cocaine induced anxiety0.60.71.41.11.2-1.20.80.80.60.00.1
Post-drug Anxiety0.50.51.21.11.0-1.00.60.50.40.20.4
Baseline Anxiety0.20.20.50.2-0.10.10.30.10.5-0.7-0.7
Tail length3.09.110.92.92.8-2.83.23.23.3-3.0-3.0
Length with tail1.96.98.72.92.9-2.92.72.92.6-2.0-1.8
Length without tail0.20.51.00.81.0-1.00.20.50.10.60.7
Times rat made contact with spout0.20.30.6-0.8-0.80.8-0.4-0.4-0.3-0.1-0.2
Lifetime Intake0.10.10.10.10.3-0.40.30.40.3-0.3-0.4
Liver weight, left2.54.05.6-2.1-2.32.4-2.0-2.4-1.91.41.3
Liver weight, right1.82.93.8-1.7-1.61.7-1.8-2.0-1.81.61.6
Locomotor activity3.45.48.62.72.9-2.92.32.62.1-1.2-1.0
Locomotor testing distance2.03.35.02.12.2-2.21.82.01.7-1.1-1.0
Locomotor testing rearing0.10.10.4-0.1-0.00.10.20.30.3-0.6-0.6
Locomotion in novel chamber0.30.40.80.40.3-0.20.60.40.8-0.9-0.9
Locomotion in novel chamber post-restriction0.81.01.40.70.9-1.01.01.21.0-1.1-1.1
Fecal boli incidents, locomotor time 11.71.83.0-1.2-1.71.7-1.4-1.7-1.20.90.8
Change in fecal boli incidents, locomotor task0.50.51.30.41.0-1.10.41.10.30.00.0
Time >=10cm from walls, locomotor time 10.50.51.3-0.1-0.10.1-0.7-0.4-0.71.11.1
Bouts of movement, locomotor time 10.20.20.30.40.3-0.30.40.50.5-0.5-0.5
Total resting periods, locomotor time 10.30.30.40.60.5-0.50.50.60.5-0.5-0.5
Rest time, locomotor task time 10.20.20.40.50.5-0.60.50.40.4-0.2-0.2
Distance moved, locomotor task time 10.50.61.5-0.5-0.10.2-0.8-0.3-0.81.21.2
Vertical activity count, locomotor time 10.10.10.3-0.6-0.30.2-0.30.1-0.2-0.1-0.2
Time >=10cm from walls, locomotor time 21.01.01.6-1.1-1.21.3-1.2-0.9-0.90.60.5
Bouts of movement, locomotor time 20.50.51.31.11.0-1.00.60.50.40.10.3
Total resting periods, locomotor time 20.50.51.21.11.0-0.90.60.50.30.20.3
Rest time, locomotor task time 20.50.61.01.01.0-0.90.80.80.6-0.2-0.2
Distance moved, locomotor task time 20.70.81.3-1.2-1.11.1-0.9-1.0-0.80.50.4
Vertical activity count, locomotor time 20.70.81.7-1.2-1.31.2-0.8-0.9-0.60.0-0.1
Light reinforcement 15.39.713.03.63.4-3.33.43.13.2-2.4-2.2
Light reinforcement 21.82.43.21.81.7-1.81.71.61.5-1.1-1.0
Bone: marrow area0.20.40.7-0.6-0.20.3-0.7-0.5-0.80.90.9
Bone: maximum diameter0.81.53.31.41.8-1.71.01.40.8-0.2-0.0
Bone: maximum force1.01.82.6-1.3-0.70.9-1.6-1.1-1.61.61.6
Bone: maximum moment0.81.42.2-1.1-0.60.8-1.4-0.9-1.41.51.4
Mean time between licks in bursts3.95.56.82.32.1-2.12.52.32.6-2.4-2.3
Mean num. licks in bursts0.00.10.2-0.00.0-0.0-0.2-0.1-0.30.40.4
Cd content in liver0.20.20.3-0.4-0.30.3-0.5-0.4-0.50.60.5
Co content in liver0.50.60.80.80.7-0.60.80.80.9-0.9-0.9
Cu content in liver0.30.31.0-0.00.3-0.2-0.4-0.2-0.51.01.0
Fe content in liver0.10.10.20.0-0.20.10.20.00.3-0.5-0.5
K content in liver0.30.30.80.50.5-0.4-0.1-0.0-0.20.80.9
Mg content in liver0.30.30.90.40.6-0.5-0.1-0.0-0.30.90.9
Mn content in liver1.51.74.01.62.0-2.00.81.30.50.50.7
Na content in liver1.11.22.6-0.4-0.50.5-1.1-1.1-1.21.61.6
Rb content in liver0.60.72.1-0.30.00.0-0.7-0.5-1.01.41.4
Se content in liver0.10.20.20.50.5-0.50.40.40.3-0.2-0.2
Sr content in liver0.20.20.6-0.2-0.40.40.1-0.00.2-0.7-0.8
Zn content in liver2.22.45.60.80.6-0.51.51.21.8-2.3-2.4
Bone: minimum diameter0.10.10.30.10.5-0.4-0.20.2-0.30.50.6
Time in familiar zone, hab. session 12.32.12.71.31.1-1.21.51.51.6-1.6-1.6
Time in novel zone, hab. session 11.11.12.3-0.9-0.40.4-1.1-0.8-1.21.51.5
Total zone transitions, hab. session 10.91.22.51.51.6-1.61.11.00.80.10.2
Total locomotion distance, hab. session 11.31.84.01.82.0-2.01.01.20.70.40.7
Locomotion velocity, hab. session 11.52.14.52.12.0-2.01.31.31.00.10.3
Time in familiar zone, hab. session 26.16.38.12.32.0-2.02.72.52.8-2.8-2.8
Time in novel zone, hab. session 24.54.46.3-1.9-1.51.6-2.3-1.9-2.42.52.5
Total zone transitions, hab. session 20.81.03.50.40.3-0.3-0.4-0.7-0.81.71.9
Total locomotion distance, hab. session 20.91.23.21.81.4-1.41.00.70.70.10.3
Locomotion velocity, hab. session 21.01.33.51.91.5-1.51.00.60.60.40.6
Novel to familiar place preference ratio4.14.36.7-1.9-1.31.4-2.2-1.9-2.32.62.6
Novelty place preference2.62.64.6-1.4-0.91.0-1.7-1.4-1.82.12.1
Time in novel zone, NPP test2.93.04.7-1.6-1.11.1-1.8-1.5-1.92.22.2
Total zone transitions, NPP test0.30.41.10.70.2-0.3-0.0-0.5-0.30.91.1
Total locomotion distance, NPP test0.30.51.60.60.3-0.3-0.2-0.4-0.41.11.3
Locomotion velocity, NPP test0.30.41.00.90.6-0.60.1-0.1-0.10.91.0
Intraocular pressure0.40.61.7-0.4-0.70.70.2-0.10.5-1.2-1.3
Delta distance traveled before/after self-admin1.61.72.21.51.3-1.41.41.41.3-1.1-1.1
Delta ambulatory time before/after self-admin1.71.82.41.51.5-1.51.41.41.3-1.0-0.9
Parametrial fat weight0.50.91.20.70.9-0.80.91.11.0-1.1-1.1
Pavlov. Cond. lever latency0.20.30.9-0.4-0.40.40.10.10.4-0.8-0.9
Pavlov. Cond. magazine entry latency2.63.44.22.01.7-1.72.01.82.0-1.8-1.7
Pavlov. Cond. change in total contacts0.00.00.10.30.3-0.30.20.10.2-0.1-0.0
Pavlov. Cond. index score0.40.51.01.00.9-0.90.70.60.5-0.1-0.0
Pavlov. Cond. latency score0.40.51.11.01.1-1.10.60.60.40.10.3
Pavlov. Cond. lever contacts0.30.40.80.60.7-0.70.10.2-0.30.80.9
Pavlov. Cond. magazine entry number0.60.71.0-1.0-0.80.8-1.0-0.8-0.90.80.7
Pavlov. Cond. intertrial magazine entries0.20.30.90.1-0.10.10.40.20.6-0.9-0.9
Pavlov. Cond. lever-magazine prob. diff.0.70.81.51.21.2-1.10.90.90.8-0.4-0.3
Pavlov. Cond. response bias0.91.11.61.31.1-1.11.21.01.1-0.9-0.8
Pavlov. Cond. lever latency0.91.22.1-0.9-1.21.2-1.0-1.5-1.11.01.0
Pavlov. Cond. magazine entry latency0.50.61.00.61.0-0.80.71.00.7-0.6-0.6
Pavlov. Cond. change in total contacts0.81.11.80.81.0-1.01.01.31.1-1.1-1.1
Pavlov. Cond. index score1.01.32.10.91.2-1.11.01.41.2-1.1-1.1
Pavlov. Cond. latency score0.91.22.00.91.2-1.21.01.41.0-0.9-0.9
Pavlov. Cond. lever contacts0.81.21.80.80.9-0.91.01.31.1-1.2-1.2
Pavlov. Cond. magazine entry number0.81.01.6-0.7-1.31.1-0.9-1.3-1.00.80.7
Pavlov. Cond. intertrial magazine entries0.30.40.9-0.7-0.90.9-0.6-0.6-0.40.0-0.1
Pavlov. Cond. lever-magazine prob. diff.1.01.32.10.91.2-1.21.01.41.1-1.0-0.9
Pavlov. Cond. response bias1.92.63.71.31.5-1.41.61.91.7-1.7-1.7
Time in closed arm before self-admin1.01.12.9-0.4-0.40.3-0.9-1.0-1.21.61.7
Time in closed arm after self-admin0.00.00.0-0.0-0.10.00.10.00.1-0.2-0.2
Time in open arm before self-admin0.91.01.30.60.9-0.81.01.11.0-1.1-1.1
Time in open arm after self-admin0.60.70.9-0.9-0.80.9-0.9-0.8-0.80.70.6
Bone: periosteal estimation0.40.82.0-0.50.10.0-0.9-0.4-1.11.41.4
Bone: periosteal perimeter0.30.41.20.51.1-1.00.10.7-0.00.50.6
Bone: post-yield work0.50.60.9-0.9-0.80.9-0.9-0.8-0.80.60.5
Progressive ratio test 1 active lever presses0.10.10.2-0.5-0.50.4-0.3-0.2-0.2-0.1-0.2
Progressive ratio test 1 breakpoint0.10.20.3-0.6-0.60.5-0.4-0.3-0.30.0-0.0
Progressive ratio test 1 inactive lever presses0.00.00.00.10.1-0.20.10.20.0-0.1-0.1
Progressive ratio test 2 active lever presses0.30.30.80.10.2-0.20.50.50.6-0.8-0.9
Progressive ratio test 2 breakpoint0.30.30.50.30.5-0.50.50.70.6-0.6-0.7
Progressive ratio test 2 inactive lever presses0.10.10.20.20.3-0.40.20.30.2-0.1-0.1
Incentive Sensitization - Responses0.30.30.90.00.2-0.20.50.50.6-0.8-0.9
Incentive Sensitization - Breakpoint0.30.30.80.20.3-0.30.50.60.7-0.8-0.9
Sum of active levers in priming session hrs 5-60.00.00.0-0.0-0.10.00.0-0.1-0.00.00.0
Progressive ratio0.30.40.9-0.4-0.90.9-0.4-1.0-0.30.20.1
Food seeking constrained by brief footshock0.10.10.30.60.2-0.30.4-0.10.3-0.1-0.0
Seeking ratio, punishment vs. effort0.20.20.60.50.7-0.80.50.50.3-0.00.0
Retroperitoneal fat weight0.31.01.5-1.2-1.21.2-1.0-1.2-1.00.60.6
Reaction time number correct0.71.02.2-1.5-1.41.3-0.8-0.7-0.6-0.3-0.4
Reaction time mean minus median0.81.01.50.81.1-0.80.91.21.1-1.0-1.0
Reaction time mean minus median AUC0.20.20.70.30.8-0.5-0.10.4-0.10.60.6
Reaction time num false alarms0.10.20.6-0.8-0.40.4-0.30.2-0.1-0.4-0.5
Reaction time num false alarms AUC0.30.30.9-1.0-0.70.7-0.4-0.0-0.2-0.5-0.7
Reaction time trials correct on left0.71.02.2-1.5-1.41.3-0.8-0.7-0.6-0.3-0.4
Reaction time trials on left0.60.92.2-1.5-1.41.3-0.8-0.7-0.6-0.2-0.3
Reaction time mean0.10.10.20.20.5-0.2-0.10.2-0.10.40.4
Reaction time mean AUC0.10.10.30.10.4-0.2-0.20.1-0.20.50.5
Median of all reaction times0.30.40.9-0.3-0.10.2-0.6-0.4-0.70.91.0
Reaction time omissions0.20.30.60.60.7-0.70.60.60.5-0.3-0.2
Reaction time false alarm rate0.00.00.1-0.2-0.00.0-0.10.2-0.10.0-0.0
Reaction time premature initiation rate1.11.52.31.10.8-0.81.31.11.4-1.5-1.5
Reaction time premature initiations0.91.23.40.40.1-0.21.00.91.2-1.7-1.8
Std. dev. reaction times0.20.30.70.60.8-0.60.50.80.6-0.4-0.4
Reaction time trials completed0.60.92.2-1.5-1.41.3-0.8-0.7-0.6-0.2-0.3
Reaction time trials AUC0.71.02.3-1.5-1.51.3-0.7-0.6-0.5-0.4-0.6
Run reversals in cocaine runway, females0.40.40.70.70.8-0.80.60.70.5-0.3-0.3
Run reversals in cocaine runway, males1.21.21.91.31.2-1.41.21.11.0-0.7-0.6
Latency to leave start box in cocaine runway1.21.33.01.31.7-1.60.91.30.8-0.00.0
Latency to leave start box in cocaine runway, F0.60.61.50.41.0-1.0-0.10.3-0.31.21.2
Latency to leave start box in cocaine runway, M2.92.84.41.31.2-1.01.71.61.9-2.1-2.1
Std. dev. time between licks in bursts0.91.12.01.11.4-1.40.91.40.9-0.4-0.4
Total sessions with >9 infusions0.10.10.2-0.10.3-0.4-0.10.2-0.20.30.3
Short access day 1 total inactive lever presses0.00.00.10.30.1-0.20.30.10.1-0.2-0.1
Short access day 10 total inactive lever presses0.10.10.2-0.0-0.00.10.20.10.3-0.4-0.5
Short access day 1 total infusions0.20.20.60.60.6-0.80.30.40.10.20.2
Short access day 10 total infusions0.10.10.2-0.1-0.0-0.10.10.20.1-0.4-0.4
Short access total infusions0.00.00.1-0.00.1-0.2-0.00.1-0.10.10.1
Short access day 1 locomotion1.11.22.21.21.4-1.51.01.30.8-0.5-0.4
Short access day 10 total locomotion4.14.55.41.92.0-2.02.32.32.2-2.2-2.2
Short access total locomotion1.01.01.50.91.1-1.21.01.20.9-0.8-0.7
One hour access (0.3 mA shock)0.10.10.3-0.5-0.40.3-0.4-0.3-0.50.30.3
Compulsive drug intake1.21.21.8-1.0-0.70.7-1.2-1.1-1.21.41.3
One hour access (shock baseline)0.20.20.50.00.0-0.10.30.40.4-0.7-0.7
Social response proportion0.60.61.81.30.8-1.00.80.50.7-0.2-0.1
Social responses6.78.611.63.43.3-3.43.03.22.8-2.0-1.9
Social time0.60.91.5-0.7-1.01.0-0.8-1.2-0.80.80.8
Soleus weight8.324.429.0-5.3-5.04.9-5.4-5.1-5.34.34.1
Bone: stiffness2.74.25.4-2.1-1.61.7-2.3-1.9-2.32.22.1
Tibialis anterior weight1.13.74.8-2.2-1.72.0-2.1-1.9-2.11.71.6
Time to tail flick, vehicle, before self-admin0.50.61.21.01.1-1.10.60.70.40.10.2
Time to tail flick, vehicle, after self-admin0.30.41.10.1-0.40.40.30.10.6-1.0-1.0
Time to tail flick, test, before self-admin0.30.30.70.80.7-0.80.30.50.20.30.4
Time to tail flick, test, after self-admin0.20.20.60.80.6-0.60.40.40.4-0.10.0
Delta time to tail flick, vehicle, before/after SA0.80.81.8-1.0-1.31.3-0.5-0.8-0.3-0.5-0.6
Delta time to tail flick, test, before/after SA0.20.20.60.20.00.00.40.20.5-0.8-0.8
Tibia length0.92.53.11.61.4-1.51.71.71.8-1.5-1.5
Ambulatory time before self-admin0.30.30.5-0.6-0.30.4-0.6-0.5-0.60.70.7
Ambulatory time after self-admin0.40.40.70.60.8-0.70.60.70.6-0.4-0.3
Bone: tissue strength1.61.51.8-1.1-1.01.1-1.3-1.4-1.31.31.3
Total heroin consumption1.82.12.51.41.5-1.51.61.51.5-1.3-1.2
Bone: trabecular number0.81.22.71.31.7-1.60.81.10.50.10.3
Bone: trabecular spacing1.01.33.0-1.3-1.71.7-0.5-0.8-0.1-0.9-1.1
Bone: trabecular thickness1.61.94.60.91.5-1.6-0.20.4-0.72.02.2
Bone: trabecular tissue density1.72.44.1-1.5-2.01.9-1.5-1.9-1.30.90.8
Water consumed over 24 hours0.60.71.4-0.7-0.30.3-0.9-0.5-1.01.21.2
Number of responses in last shaping day0.20.20.40.20.5-0.70.40.60.3-0.4-0.4