Hub : Genes

Mindy4b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr2_145189733_145190730 0.02 0.02 2.5e-03 0.01 0.01 0.02 0.01 2.2e-03 3.4e-03 1.2e-03 5.1e-03
2 BLA gene expression Mindy4b 0.38 0.19 1.8e-12 0.16 0.2 0.18 0.19 4.5e-09 1.1e-10 6.1e-10 2.8e-10
3 BLA mRNA stability Mindy4b 0.1 0.08 2.0e-04 0.05 0.06 0.05 0.06 1.3e-03 4.4e-04 1.6e-03 3.9e-04
4 IC gene expression Mindy4b 0.31 0.2 8.8e-10 0.14 0.18 0.15 0.16 1.5e-06 4.4e-08 8.1e-07 4.8e-07
5 NAcc mRNA stability Mindy4b 0.05 0.05 1.3e-05 0.03 0.03 0.03 0.03 8.7e-06 2.0e-05 2.8e-05 2.6e-05
6 PL mRNA stability Mindy4b 0.05 0.05 5.3e-05 0.04 0.03 0.02 0.03 9.4e-05 2.6e-04 1.1e-03 2.8e-04
7 PL intron excision ratio chr2_145189733_145190730 0.08 0.09 1.6e-04 0.03 0.03 0.03 0.03 1.6e-04 2.3e-04 3.5e-04 1.9e-04
8 pVTA gene expression Mindy4b 0.08 0.06 1.1e-06 0.09 0.08 0.08 0.08 2.0e-07 8.0e-07 5.1e-07 9.5e-07
9 Brain mRNA stability Mindy4b 0.02 0.03 7.4e-03 0.01 0.02 0.01 0.02 2.2e-02 3.7e-03 2.1e-02 5.5e-03
10 Brain gene expression Mindy4b 0.09 0.07 1.3e-08 0.09 0.09 0.09 0.09 6.7e-09 1.3e-08 1.6e-08 1.8e-08
11 OFC gene expression Mindy4b 0.24 0.19 6.4e-03 0.02 0.01 0.01 0.01 1.3e-01 2.0e-01 2.3e-01 2.0e-01
12 NAcc gene expression Mindy4b 0.13 0.11 5.6e-09 0.07 0.06 0.06 0.06 3.2e-10 3.6e-09 5.1e-10 4.0e-10
13 PL gene expression Mindy4b 0.38 0.19 0.0e+00 0.2 0.21 0.22 0.22 2.0e-21 4.9e-23 4.9e-24 3.8e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.81.42.40.61.11.31.2-1.1-1.1-1.1-1.31.2-1.1-1.3-1.1-1.5
Area under the delay curve2.84.310.13.2-2.2-2.0-2.12.12.12.11.6-1.91.81.61.82.2
BMI with tail2.68.937.96.2-2.7-2.6-2.62.62.62.62.3-2.42.72.22.72.6
BMI without tail1.36.816.64.1-2.7-2.5-2.62.42.52.52.1-2.42.32.02.52.7
Body weight2.08.927.85.3-2.8-2.7-2.82.72.72.72.7-2.82.72.62.82.5
Weight adjusted by age0.20.63.92.00.00.30.3-0.3-0.3-0.3-1.00.6-0.7-1.1-0.10.2
Bone surface0.20.33.41.9-0.4-0.2-0.30.30.30.3-0.0-0.20.2-0.00.4-0.0
Bone volume0.51.01.80.70.91.01.0-0.9-0.9-0.9-1.11.0-1.0-1.1-0.9-1.3
Breakpoint value in progressive ratio session0.00.10.20.3-0.2-0.1-0.20.10.30.3-0.1-0.00.1-0.10.30.5
Number of licking bursts0.10.33.61.9-0.1-0.1-0.10.30.10.1-0.0-0.0-0.0-0.00.3-0.1
Context. condit. distance diff. score0.70.81.1-0.80.80.90.9-0.9-0.9-0.9-1.00.9-1.1-1.0-0.9-0.8
Locomotion velocity, session 10.20.30.4-0.30.50.60.5-0.6-0.5-0.5-0.50.5-0.7-0.5-0.5-0.6
Locomotion distance, session 10.10.20.7-0.30.50.30.3-0.3-0.3-0.30.20.1-0.50.2-0.3-0.8
Locomotion velocity, session 24.65.56.8-2.62.42.32.3-2.4-2.3-2.3-2.12.3-2.5-2.1-2.3-2.6
Locomotion distance, session 20.20.31.5-1.20.60.50.5-0.5-0.5-0.5-0.10.3-0.7-0.1-0.5-0.6
Locomotion velocity, session 30.10.10.3-0.3-0.3-0.3-0.30.30.20.20.2-0.20.10.10.20.6
Locomotion distance, session 30.10.10.3-0.2-0.4-0.4-0.30.30.30.30.0-0.20.20.00.30.6
Stereotopy head waving bouts, day 30.80.91.2-0.71.11.01.0-0.9-1.0-1.0-0.81.0-0.9-0.9-1.0-1.1
Stereotopy head waving duration, day 30.91.11.3-1.11.11.11.1-1.0-1.1-1.1-0.91.0-1.0-0.9-1.1-1.1
Locomotion velocity, session 70.10.10.4-0.20.30.40.3-0.5-0.3-0.3-0.40.4-0.6-0.4-0.3-0.0
Locomotion distance, session 70.10.20.6-0.80.40.30.4-0.3-0.4-0.4-0.30.3-0.3-0.2-0.4-0.3
Stereotopy head waving bouts, day 70.40.50.9-0.20.60.80.7-0.8-0.6-0.6-0.90.8-0.8-0.9-0.6-0.5
Stereotopy head waving duration, day 70.10.20.5-0.10.30.40.3-0.6-0.3-0.3-0.60.5-0.5-0.7-0.3-0.1
Locomotion velocity, session 80.10.10.40.4-0.1-0.2-0.20.10.20.20.7-0.4-0.10.60.20.4
Locomotion distance, session 80.10.20.4-0.50.50.50.4-0.5-0.4-0.4-0.20.3-0.7-0.2-0.4-0.5
Degree of sensitization distance0.10.10.3-0.10.40.40.4-0.3-0.3-0.3-0.10.3-0.2-0.1-0.3-0.5
Degree of sensitization stereotypy0.40.40.7-0.50.60.70.6-0.8-0.5-0.5-0.80.7-0.8-0.8-0.5-0.4
Conditioned locomotion0.10.10.5-0.2-0.3-0.3-0.30.20.30.30.3-0.30.40.30.30.7
Cocaine response after cond. corrected1.32.04.02.0-1.4-1.3-1.41.41.41.41.3-1.41.01.31.31.3
Cocaine response after cond. not corrected1.62.33.51.9-1.7-1.4-1.61.51.61.61.3-1.51.21.31.41.5
Cocaine response before conditioning0.40.42.2-1.50.30.50.4-0.6-0.4-0.4-0.80.6-0.5-0.8-0.6-0.1
Saline control response0.71.01.40.0-1.1-1.0-1.10.91.11.10.9-1.01.10.90.91.2
Bone: connectivity density0.20.43.92.0-0.2-0.2-0.20.40.20.20.2-0.20.40.20.3-0.2
Bone: cortical apparent density3.75.86.7-2.32.32.42.4-2.2-2.4-2.4-2.62.5-2.2-2.6-2.5-2.4
Bone: cortical area0.10.10.7-0.9-0.10.00.1-0.1-0.1-0.1-0.40.20.0-0.4-0.20.3
Bone: cortical porosity0.10.10.30.3-0.2-0.2-0.30.20.30.30.5-0.40.10.50.30.2
Bone: cortical porosity0.40.50.60.5-0.7-0.6-0.70.60.80.80.7-0.70.50.70.70.8
Bone: cortical thickness1.22.16.5-2.61.21.31.3-1.4-1.3-1.3-1.51.4-1.2-1.5-1.4-0.7
Bone: cortical thickness0.10.10.8-0.9-0.1-0.1-0.10.00.10.10.1-0.10.20.10.00.4
Bone: cortical tissue density3.25.05.8-2.12.12.22.2-2.1-2.3-2.3-2.42.3-2.0-2.4-2.4-2.3
Condit. Reinf. active minus inactive responses6.16.911.53.4-2.3-2.6-2.52.72.52.53.0-2.72.52.92.52.0
Condit. Reinf. active-inactive response ratio5.55.810.43.2-2.0-2.3-2.22.52.22.22.9-2.52.42.82.21.6
Condit. Reinf. active responses7.910.112.63.1-3.0-3.2-3.23.33.13.13.5-3.33.13.63.12.7
Condit. Reinf. inactive responses1.92.53.40.5-1.7-1.6-1.61.61.61.61.6-1.61.51.71.61.8
Incentive salience index mean2.63.34.81.8-1.6-1.8-1.82.01.71.72.2-1.91.92.21.71.3
Condit. Reinf. lever presses0.00.10.3-0.5-0.1-0.2-0.10.30.10.10.3-0.20.20.40.1-0.1
Condit. Reinf. active minus inactive responses1.42.22.61.3-1.6-1.5-1.51.51.51.51.4-1.51.61.41.51.5
Condit. Reinf. active-inactive response ratio1.82.86.42.5-1.7-1.6-1.61.81.61.61.4-1.51.61.41.61.4
Condit. Reinf. active responses0.20.40.5-0.5-0.7-0.7-0.60.60.60.60.5-0.60.60.50.50.7
Condit. Reinf. inactive responses0.71.06.3-2.50.80.70.7-0.9-0.7-0.7-0.60.7-0.8-0.6-0.8-0.5
Condit. Reinf. lever presses2.43.54.20.4-1.9-2.0-2.01.82.02.02.0-2.01.92.01.91.9
Condit. Reinf. lever reinforcers received0.20.30.5-0.7-0.6-0.6-0.60.50.60.60.4-0.50.50.40.50.7
Conditioned reinforcement - actives0.51.95.82.41.41.41.3-1.3-1.3-1.3-0.71.1-1.3-0.9-1.3-1.3
Conditioned reinforcement - inactives0.20.54.12.0-0.1-0.2-0.30.20.30.30.7-0.50.20.70.50.1
Conditioned locomotion2.13.131.15.61.11.11.0-0.8-1.0-1.0-0.40.8-0.9-0.7-0.8-1.0
Patch foraging indifference point 0 sec0.10.41.5-1.20.10.40.3-0.5-0.3-0.3-0.90.5-0.7-0.9-0.20.0
Patch foraging indifference point AUC0.10.20.7-0.90.50.30.3-0.3-0.3-0.30.20.1-0.30.3-0.5-0.6
Delay disc. indifference point, 0s delay2.22.510.83.3-1.5-1.3-1.41.41.41.41.2-1.31.41.11.31.4
Delay disc. indifference point, 16s delay4.66.510.33.2-2.6-2.6-2.62.62.52.52.4-2.52.52.32.32.4
Delay disc. indifference point, 2s delay1.61.810.83.3-1.0-0.9-1.01.11.01.01.1-1.01.21.00.90.9
Delay disc. indifference point, 24s delay1.01.62.30.5-1.5-1.5-1.41.51.31.41.2-1.31.31.21.01.2
Delay disc. indifference point, 4s delay2.02.115.94.0-1.1-0.9-1.01.01.01.00.8-0.91.00.70.91.1
Delay disc. indifference point, 8s delay1.01.72.51.5-1.6-1.4-1.41.31.41.30.9-1.21.00.81.11.6
Indifference point function ln k0.51.53.31.8-1.4-1.2-1.21.11.21.20.7-1.01.10.61.41.4
Indifference point function log k0.51.53.31.8-1.4-1.2-1.21.11.21.20.7-1.01.10.61.41.4
Patch foraging total patch changes 0 sec0.10.22.0-1.4-0.20.10.0-0.2-0.1-0.1-0.50.2-0.4-0.6-0.10.1
Patch foraging total patch changes 12 sec1.11.42.0-0.81.31.21.2-1.2-1.2-1.2-1.11.2-1.4-1.1-1.2-1.1
Patch foraging total patch changes 18 sec0.20.51.01.00.70.80.6-0.9-0.5-0.5-0.50.6-0.9-0.5-0.5-0.4
Patch foraging total patch changes 24 sec0.31.06.8-2.60.60.70.6-0.8-0.6-0.6-0.90.7-0.9-0.8-0.8-0.4
Patch foraging total patch changes 6 sec0.50.98.2-2.90.10.40.3-0.5-0.2-0.2-0.90.5-1.0-0.8-0.50.2
Patch foraging time to switch 0 sec0.41.42.00.11.11.31.2-1.3-1.1-1.1-1.41.3-1.4-1.4-1.1-0.8
Patch foraging water rate 0 sec0.31.11.41.1-1.2-1.1-1.11.11.01.01.0-1.11.00.91.01.0
Patch foraging water rate 12 sec0.20.81.91.00.60.60.7-0.6-0.9-0.9-1.10.9-0.8-1.4-0.9-0.5
Patch foraging water rate 18 sec0.10.10.5-0.1-0.5-0.4-0.40.70.20.20.0-0.20.50.10.20.4
Patch foraging water rate 24 sec0.60.83.9-2.00.70.70.7-0.6-0.9-0.9-0.80.7-0.7-0.8-0.9-0.8
Patch foraging water rate 6 sec0.30.51.21.1-0.9-0.8-0.80.60.70.70.2-0.50.40.10.81.0
Seeking ratio, delayed vs. immediate footshock2.13.017.3-4.21.01.11.2-1.4-1.5-1.4-1.71.4-1.4-1.6-1.4-1.0
Distance traveled before self-admin0.10.21.41.20.30.20.1-0.3-0.0-0.00.5-0.1-0.30.5-0.0-0.3
Distance traveled after self-admin0.10.21.21.1-0.1-0.2-0.30.20.40.40.7-0.50.30.80.40.0
Extensor digitorum longus weight1.87.311.03.3-2.7-2.6-2.72.62.72.72.6-2.72.62.62.72.5
Bone: elastic displacement0.10.10.5-0.70.50.40.4-0.3-0.4-0.4-0.10.3-0.2-0.1-0.5-0.3
Bone: elastic work0.60.82.8-1.70.90.80.8-0.8-0.8-0.8-0.60.7-0.7-0.6-1.0-0.5
Bone: endosteal estimation1.23.06.82.6-1.7-1.7-1.71.81.71.71.4-1.61.71.41.71.3
Bone: endosteal perimeter0.61.64.82.2-1.1-1.2-1.21.31.21.21.2-1.21.21.21.20.7
Epididymis fat weight0.21.01.4-1.2-0.8-1.0-0.90.90.90.91.2-1.01.01.20.80.7
Delta time in closed arm before/after self-admin0.20.20.20.30.50.40.4-0.3-0.5-0.5-0.30.4-0.5-0.3-0.5-0.5
Delta time in open arm before/after self-admin0.40.41.1-0.90.90.60.7-0.5-0.7-0.7-0.20.5-0.3-0.1-0.7-1.1
Diff in mean of infusions in LGA sessions0.20.45.12.30.10.1-0.10.00.30.30.4-0.20.10.40.30.0
Delay discount exponential model param2.73.69.1-3.02.01.81.9-1.9-1.8-1.9-1.51.7-1.7-1.4-1.6-1.9
Extinction: sum of active levers before priming1.01.57.92.8-1.1-1.1-1.01.21.01.01.0-1.00.90.81.01.0
Active lever presses in extinction session 60.60.61.7-0.7-0.9-0.6-0.80.31.01.00.1-0.50.10.21.01.3
Bone: final force0.10.20.5-0.60.20.30.3-0.4-0.3-0.3-0.70.5-0.2-0.7-0.30.0
Bone: final moment0.10.20.8-0.90.20.30.3-0.4-0.3-0.3-0.70.5-0.2-0.7-0.4-0.2
Food consumed during 24 hour testing period0.61.12.10.3-1.4-1.2-1.21.01.21.20.6-1.01.00.61.21.4
Glucose2.94.65.62.2-2.0-2.2-2.12.32.02.02.4-2.22.42.32.01.6
Heart weight0.10.21.8-1.3-0.2-0.2-0.20.00.30.30.0-0.10.2-0.00.00.4
Delay discount hyperbolic model param3.24.113.0-3.62.01.81.9-2.0-1.9-1.9-1.61.8-1.8-1.5-1.7-1.9
Intermittent access intake day 1-15 change0.42.124.0-4.90.70.60.5-0.5-0.5-0.5-0.30.3-0.30.2-0.6-0.8
Intermittent access intake escalation0.42.226.1-5.10.70.60.5-0.5-0.5-0.5-0.30.3-0.30.2-0.5-0.8
Intermittent access intake escalation 20.30.66.7-2.60.30.30.10.2-0.0-0.00.2-0.10.30.6-0.0-0.4
Intermitt. access day 1 inactive lever presses0.11.42.3-0.9-1.1-1.2-1.21.31.11.11.4-1.31.31.50.70.8
Intermitt. access day 15 inactive lever presses0.00.20.9-0.10.2-0.1-0.10.30.10.10.9-0.50.70.9-0.1-0.5
Intermitt. access escalation Index0.72.320.8-4.61.21.00.9-0.9-0.8-0.8-0.50.7-0.8-0.3-0.8-1.1
Intermittent access day 1 total infusions0.41.213.93.70.50.50.4-0.4-0.4-0.40.10.2-0.3-0.0-0.2-0.5
Intermittent access day 15 total infusions0.10.30.8-0.50.80.70.5-0.4-0.5-0.50.10.2-0.30.3-0.5-0.9
Intermittent access terminal intake (last 3 days)0.10.20.5-0.50.60.50.3-0.2-0.3-0.30.3-0.0-0.10.5-0.3-0.7
Intermittent access total infusions0.50.61.2-0.61.11.00.8-0.8-0.8-0.8-0.20.5-0.7-0.2-0.8-1.1
Intermittent access day 1 locomotion0.61.114.13.80.10.1-0.00.00.10.10.6-0.20.20.40.2-0.1
Intermittent access day 15 total locomotion0.20.81.91.4-0.7-0.6-0.80.80.80.81.0-0.90.81.20.80.6
Intermittent access total locomotion1.01.214.73.80.10.0-0.00.20.10.10.6-0.20.20.40.0-0.2
Intermittent access standard deviation0.10.51.00.80.90.70.8-0.4-0.8-0.8-0.40.6-0.4-0.4-0.7-1.0
Left kidney weight0.11.011.43.4-0.00.30.1-0.50.00.1-0.40.3-0.7-0.60.00.3
Right kidney weight0.10.51.2-0.70.50.70.6-1.0-0.5-0.5-0.90.7-1.1-1.0-0.5-0.3
Cocaine induced anxiety0.20.54.72.2-0.1-0.2-0.20.30.30.30.9-0.40.40.60.20.1
Post-drug Anxiety0.10.11.21.10.30.30.2-0.2-0.1-0.10.10.1-0.2-0.0-0.3-0.2
Baseline Anxiety0.81.46.9-2.60.81.00.9-1.0-0.9-0.9-1.21.0-1.0-1.1-1.0-0.7
Tail length0.10.81.1-1.0-1.1-0.8-1.00.60.90.90.6-0.90.40.71.11.1
Length with tail0.31.11.50.8-1.1-1.1-1.21.01.01.01.2-1.20.91.21.20.8
Length without tail0.42.213.03.6-0.9-1.1-1.11.21.01.11.5-1.21.31.41.20.6
Times rat made contact with spout0.10.10.3-0.50.30.30.3-0.3-0.3-0.3-0.30.3-0.3-0.3-0.4-0.5
Lifetime Intake0.91.11.81.11.31.31.1-1.2-1.1-1.1-0.50.9-1.0-0.6-1.0-1.3
Liver weight, left0.30.55.62.40.30.20.4-0.3-0.3-0.2-0.30.4-0.2-0.5-0.2-0.2
Liver weight, right1.42.57.1-2.71.61.51.5-1.5-1.5-1.5-1.31.4-1.2-1.2-1.4-1.6
Locomotor activity1.32.12.6-0.2-1.5-1.4-1.51.31.61.61.5-1.51.51.61.51.5
Locomotor testing distance3.27.89.61.5-2.8-2.8-2.92.72.92.93.0-2.93.03.12.82.6
Locomotor testing rearing0.31.16.4-2.5-0.8-0.9-0.90.80.70.71.0-0.90.81.10.50.5
Locomotion in novel chamber0.81.15.7-2.41.21.01.0-1.0-0.8-0.8-0.30.7-0.9-0.2-0.8-1.1
Locomotion in novel chamber post-restriction0.51.48.2-2.90.80.90.8-1.1-0.9-0.9-0.90.9-1.0-0.8-0.9-0.7
Fecal boli incidents, locomotor time 10.41.13.92.0-0.6-0.9-0.80.90.70.71.5-1.11.11.30.70.2
Change in fecal boli incidents, locomotor task1.11.212.4-3.50.20.40.4-0.6-0.5-0.4-0.90.6-0.7-0.6-0.4-0.1
Time >=10cm from walls, locomotor time 11.92.323.0-4.80.50.50.7-0.7-0.8-0.8-1.10.8-0.8-1.1-0.8-0.6
Bouts of movement, locomotor time 11.21.52.8-1.71.01.01.1-1.2-1.2-1.2-1.41.2-1.4-1.4-1.2-0.9
Total resting periods, locomotor time 12.32.63.8-1.11.41.51.5-1.7-1.7-1.6-1.81.7-1.7-2.0-1.7-1.3
Rest time, locomotor task time 11.93.14.3-0.81.71.81.8-1.8-1.9-1.8-1.91.8-1.6-2.1-1.9-1.6
Distance moved, locomotor task time 10.41.21.90.4-1.0-1.1-1.11.11.11.11.3-1.21.21.41.10.9
Vertical activity count, locomotor time 10.10.40.70.0-0.5-0.6-0.60.60.70.60.8-0.70.60.90.70.4
Time >=10cm from walls, locomotor time 21.74.841.8-6.51.31.21.3-1.4-1.4-1.3-1.31.3-1.4-1.2-1.3-1.4
Bouts of movement, locomotor time 21.24.019.8-4.41.11.51.4-1.8-1.4-1.4-2.21.7-2.3-2.0-1.3-0.7
Total resting periods, locomotor time 20.83.011.4-3.41.01.41.3-1.7-1.2-1.2-2.11.6-2.2-2.0-1.2-0.6
Rest time, locomotor task time 20.50.92.91.70.60.90.7-0.8-0.7-0.6-1.20.9-0.9-1.4-0.6-0.3
Distance moved, locomotor task time 20.81.113.8-3.7-0.2-0.3-0.20.10.20.20.3-0.30.20.50.10.1
Vertical activity count, locomotor time 21.32.930.6-5.50.90.70.8-0.9-0.8-0.8-0.70.7-0.9-0.4-0.9-0.9
Light reinforcement 10.93.912.43.5-1.7-1.8-1.81.91.81.81.9-1.92.01.81.51.5
Light reinforcement 20.30.77.52.7-0.4-0.4-0.40.40.50.50.4-0.40.70.30.40.4
Bone: marrow area1.02.56.12.5-1.6-1.5-1.51.71.51.51.3-1.41.61.31.51.1
Bone: maximum diameter0.00.00.10.1-0.10.00.00.10.00.0-0.30.1-0.1-0.3-0.10.0
Bone: maximum force0.10.10.30.2-0.4-0.3-0.30.40.30.30.1-0.20.50.10.30.5
Bone: maximum moment0.00.10.2-0.1-0.3-0.3-0.30.30.30.30.0-0.20.50.00.20.3
Mean time between licks in bursts0.63.75.00.3-1.8-2.0-1.92.01.91.92.2-2.02.12.21.62.1
Mean num. licks in bursts0.10.44.4-2.10.10.20.1-0.4-0.1-0.1-0.20.1-0.1-0.2-0.4-0.0
Cd content in liver0.70.71.1-0.60.90.90.8-1.0-0.8-0.8-0.80.8-1.0-0.8-0.8-0.9
Co content in liver1.51.83.20.9-1.7-1.4-1.51.31.51.50.9-1.21.10.91.51.8
Cu content in liver1.11.31.90.9-1.2-1.2-1.21.11.21.21.0-1.11.11.01.21.4
Fe content in liver0.00.00.1-0.20.20.10.2-0.1-0.2-0.2-0.10.1-0.0-0.1-0.2-0.0
K content in liver0.20.20.6-0.80.30.30.4-0.3-0.4-0.4-0.70.5-0.2-0.7-0.4-0.4
Mg content in liver0.20.20.50.1-0.6-0.5-0.50.60.50.50.2-0.40.70.20.50.4
Mn content in liver0.00.00.1-0.2-0.3-0.2-0.20.30.20.2-0.1-0.10.2-0.10.20.2
Na content in liver0.10.10.4-0.70.10.20.2-0.3-0.2-0.2-0.50.3-0.2-0.5-0.20.1
Rb content in liver4.04.75.81.8-2.2-2.2-2.22.22.22.22.0-2.12.22.02.22.4
Se content in liver0.00.00.1-0.10.20.20.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.2-0.1
Sr content in liver1.11.01.2-0.91.01.01.0-1.0-1.0-1.0-0.91.0-1.0-0.9-1.0-1.1
Zn content in liver0.40.51.21.1-0.5-0.6-0.60.60.60.60.8-0.70.70.80.60.3
Bone: minimum diameter1.73.33.81.5-1.8-1.9-1.81.91.81.81.9-1.91.91.91.81.8
Time in familiar zone, hab. session 11.41.52.5-1.21.01.21.1-1.3-1.1-1.1-1.61.3-1.3-1.5-1.1-1.0
Time in novel zone, hab. session 10.50.61.40.8-0.5-0.6-0.60.80.60.61.2-0.90.91.20.60.5
Total zone transitions, hab. session 11.01.42.00.4-1.1-1.2-1.21.11.31.31.4-1.31.01.41.31.3
Total locomotion distance, hab. session 10.40.60.80.2-0.7-0.8-0.80.70.80.80.9-0.80.70.90.80.8
Locomotion velocity, hab. session 10.40.60.80.2-0.7-0.8-0.80.70.80.80.9-0.80.60.90.80.8
Time in familiar zone, hab. session 22.52.93.6-1.41.51.71.6-1.7-1.7-1.7-1.91.8-1.8-1.9-1.7-1.6
Time in novel zone, hab. session 22.42.63.41.3-1.5-1.6-1.61.61.61.61.9-1.71.71.91.61.6
Total zone transitions, hab. session 20.20.31.2-1.10.60.40.4-0.5-0.4-0.40.00.2-0.60.1-0.4-0.5
Total locomotion distance, hab. session 20.30.40.7-0.4-0.6-0.7-0.70.60.70.70.8-0.70.50.80.70.5
Locomotion velocity, hab. session 20.20.30.7-0.8-0.4-0.5-0.50.40.40.40.6-0.60.30.70.50.3
Novel to familiar place preference ratio0.00.00.10.30.30.30.3-0.1-0.2-0.2-0.00.2-0.0-0.0-0.2-0.1
Novelty place preference0.10.20.30.10.60.50.5-0.4-0.5-0.5-0.20.4-0.3-0.2-0.5-0.3
Time in novel zone, NPP test0.10.20.30.30.60.60.5-0.4-0.5-0.5-0.20.4-0.3-0.2-0.5-0.3
Total zone transitions, NPP test0.10.10.4-0.4-0.2-0.3-0.30.30.30.30.6-0.40.10.60.30.4
Total locomotion distance, NPP test0.00.00.1-0.1-0.0-0.1-0.10.10.10.10.3-0.2-0.00.40.10.2
Locomotion velocity, NPP test0.00.00.1-0.40.0-0.1-0.10.10.10.10.3-0.20.00.40.10.1
Intraocular pressure0.71.14.2-2.0-0.7-0.9-0.91.00.70.81.3-1.11.11.30.60.2
Delta distance traveled before/after self-admin0.40.51.8-1.30.60.60.6-0.5-0.7-0.7-0.70.6-0.5-0.6-0.7-0.6
Delta ambulatory time before/after self-admin0.10.10.1-0.20.30.40.3-0.3-0.3-0.3-0.30.3-0.3-0.4-0.3-0.3
Parametrial fat weight0.51.21.41.0-1.1-1.2-1.11.11.21.21.2-1.21.11.11.01.0
Pavlov. Cond. lever latency0.60.71.81.3-0.7-0.7-0.80.60.80.81.1-0.90.71.00.80.6
Pavlov. Cond. magazine entry latency0.10.10.3-0.6-0.2-0.1-0.0-0.0-0.0-0.0-0.50.20.1-0.5-0.00.0
Pavlov. Cond. change in total contacts0.30.31.3-1.10.40.40.4-0.3-0.5-0.5-0.50.5-0.5-0.5-0.5-0.4
Pavlov. Cond. index score1.31.63.5-1.90.91.01.1-1.0-1.2-1.2-1.61.3-1.1-1.6-1.2-1.0
Pavlov. Cond. latency score1.01.32.6-1.60.80.91.0-0.9-1.1-1.1-1.51.2-0.9-1.5-1.1-1.0
Pavlov. Cond. lever contacts0.40.51.0-1.00.50.50.6-0.5-0.7-0.7-0.90.7-0.6-0.9-0.6-0.5
Pavlov. Cond. magazine entry number0.40.51.61.3-0.3-0.5-0.50.50.60.61.0-0.70.61.10.60.3
Pavlov. Cond. intertrial magazine entries0.81.02.01.4-0.7-0.8-0.90.90.90.91.3-1.00.71.30.90.8
Pavlov. Cond. lever-magazine prob. diff.1.41.73.6-1.91.01.11.2-1.1-1.2-1.2-1.61.3-1.1-1.6-1.2-1.1
Pavlov. Cond. response bias0.50.71.9-1.40.50.60.7-0.6-0.7-0.7-1.10.8-0.7-1.1-0.7-0.4
Pavlov. Cond. lever latency0.81.11.20.01.11.11.1-0.9-1.1-1.1-1.11.1-1.0-1.1-1.0-1.1
Pavlov. Cond. magazine entry latency0.10.10.1-0.3-0.3-0.3-0.30.20.30.30.3-0.30.10.30.20.3
Pavlov. Cond. change in total contacts0.51.11.4-0.3-1.2-1.2-1.11.11.11.11.1-1.11.01.11.01.2
Pavlov. Cond. index score0.71.11.3-0.1-1.1-1.1-1.10.91.11.11.2-1.10.91.21.01.1
Pavlov. Cond. latency score0.91.41.80.2-1.2-1.3-1.31.11.31.31.3-1.31.11.31.21.2
Pavlov. Cond. lever contacts0.50.70.8-0.1-0.9-0.9-0.90.70.90.90.9-0.90.80.90.80.9
Pavlov. Cond. magazine entry number0.50.60.7-0.40.80.80.9-0.8-0.9-0.9-0.90.9-0.6-0.9-0.8-0.8
Pavlov. Cond. intertrial magazine entries0.20.50.6-0.80.80.70.8-0.7-0.8-0.8-0.70.8-0.6-0.7-0.7-0.7
Pavlov. Cond. lever-magazine prob. diff.0.71.01.2-0.1-1.1-1.1-1.10.91.11.11.1-1.10.91.11.01.0
Pavlov. Cond. response bias0.40.60.8-0.3-0.8-0.8-0.80.60.80.80.8-0.80.70.80.70.9
Time in closed arm before self-admin0.91.62.00.81.31.21.3-1.2-1.4-1.4-1.31.3-1.1-1.4-1.4-1.4
Time in closed arm after self-admin0.70.81.50.91.10.90.9-0.8-1.0-1.0-0.40.7-0.7-0.5-1.0-1.2
Time in open arm before self-admin4.45.47.5-2.5-2.6-2.4-2.42.12.52.51.7-2.21.81.92.52.7
Time in open arm after self-admin0.70.83.8-2.0-0.9-0.9-0.80.70.80.80.4-0.60.60.40.81.0
Bone: periosteal estimation0.51.21.81.3-1.2-1.2-1.11.21.11.10.8-1.01.20.81.11.0
Bone: periosteal perimeter0.10.11.51.2-0.2-0.1-0.10.30.10.1-0.20.00.2-0.20.1-0.1
Bone: post-yield work3.15.37.72.8-2.3-2.3-2.32.32.32.32.1-2.22.42.12.32.3
Progressive ratio test 1 active lever presses0.91.52.8-1.71.41.41.2-1.4-1.3-1.3-0.81.0-1.0-0.7-1.2-1.4
Progressive ratio test 1 breakpoint0.91.62.3-1.31.51.51.3-1.5-1.3-1.3-0.81.1-1.1-0.8-1.2-1.4
Progressive ratio test 1 inactive lever presses0.10.20.50.50.0-0.3-0.20.30.10.10.7-0.40.70.70.3-0.2
Progressive ratio test 2 active lever presses0.50.78.62.90.20.30.1-0.2-0.1-0.10.10.1-0.20.0-0.0-0.1
Progressive ratio test 2 breakpoint0.70.810.83.30.00.2-0.0-0.1-0.0-0.00.2-0.0-0.10.10.10.0
Progressive ratio test 2 inactive lever presses0.10.51.51.2-0.4-0.4-0.50.60.50.50.9-0.70.70.90.50.3
Incentive Sensitization - Responses1.02.726.45.1-1.0-0.8-0.90.90.90.90.8-0.80.60.60.91.0
Incentive Sensitization - Breakpoint1.22.726.65.2-1.0-0.8-0.90.90.90.90.8-0.80.60.70.91.0
Sum of active levers in priming session hrs 5-60.80.72.41.5-0.7-0.7-0.70.60.90.90.9-0.80.50.80.90.8
Progressive ratio0.30.86.12.5-0.8-0.4-0.60.60.60.60.1-0.40.60.00.60.9
Food seeking constrained by brief footshock1.21.45.82.4-1.3-1.1-1.21.01.11.00.5-0.91.00.51.11.4
Seeking ratio, punishment vs. effort0.10.20.3-0.1-0.5-0.6-0.50.40.40.40.6-0.50.30.60.40.4
Retroperitoneal fat weight2.08.910.53.2-3.0-3.2-3.02.92.93.02.9-3.02.92.83.12.7
Reaction time number correct0.20.60.8-0.50.80.80.8-0.7-0.7-0.7-0.60.7-0.9-0.8-0.9-0.8
Reaction time mean minus median2.113.416.91.7-4.1-3.9-4.03.73.93.93.4-3.83.43.53.83.9
Reaction time mean minus median AUC2.013.616.81.5-4.1-4.0-4.03.83.93.93.5-3.83.53.63.73.8
Reaction time num false alarms2.64.45.6-1.0-2.2-2.4-2.22.12.12.12.1-2.22.22.22.21.9
Reaction time num false alarms AUC1.22.83.6-1.4-1.8-1.9-1.81.61.61.61.6-1.71.71.71.81.5
Reaction time trials correct on left0.20.60.8-0.50.80.80.8-0.7-0.7-0.7-0.60.7-0.9-0.8-0.9-0.8
Reaction time trials on left0.10.40.6-0.30.70.60.6-0.5-0.6-0.6-0.50.6-0.7-0.6-0.8-0.7
Reaction time mean5.812.944.06.6-3.4-3.3-3.33.33.33.32.9-3.13.22.73.23.4
Reaction time mean AUC5.413.040.46.4-3.5-3.4-3.43.43.33.33.0-3.23.32.83.33.4
Median of all reaction times6.29.851.37.2-2.7-2.6-2.62.62.62.62.3-2.42.62.02.62.7
Reaction time omissions10.316.822.84.8-4.0-4.2-4.04.33.93.94.3-4.14.34.33.83.4
Reaction time false alarm rate2.53.54.4-1.0-2.0-2.1-2.01.81.81.81.8-1.92.01.92.01.8
Reaction time premature initiation rate1.31.911.3-3.40.61.10.8-1.2-0.8-0.8-1.61.2-1.6-1.4-0.8-0.2
Reaction time premature initiations0.72.29.9-3.10.81.21.0-1.4-0.9-0.9-1.71.3-1.9-1.6-1.0-0.4
Std. dev. reaction times4.615.417.73.8-4.2-4.1-4.14.04.04.03.6-3.93.83.63.94.0
Reaction time trials completed0.10.40.6-0.30.70.60.6-0.5-0.6-0.6-0.50.6-0.7-0.6-0.8-0.7
Reaction time trials AUC0.10.40.6-0.10.70.60.7-0.5-0.6-0.6-0.40.6-0.7-0.6-0.8-0.7
Run reversals in cocaine runway, females0.30.44.5-2.10.30.10.2-0.0-0.3-0.30.00.1-0.10.0-0.2-0.5
Run reversals in cocaine runway, males0.20.30.8-0.10.70.60.5-0.5-0.5-0.50.00.3-0.30.0-0.6-0.9
Latency to leave start box in cocaine runway0.30.34.4-2.10.10.10.0-0.1-0.1-0.10.0-0.0-0.20.20.0-0.1
Latency to leave start box in cocaine runway, F1.11.410.1-3.20.90.90.8-0.8-0.9-0.9-0.70.7-0.8-0.5-0.8-1.0
Latency to leave start box in cocaine runway, M1.41.33.61.9-1.2-1.1-1.11.01.11.10.9-1.00.80.91.41.2
Std. dev. time between licks in bursts4.58.510.52.0-3.0-2.9-3.03.03.03.03.0-3.03.03.02.83.2
Total sessions with >9 infusions1.41.719.34.40.70.60.5-0.6-0.5-0.50.10.3-0.4-0.1-0.4-0.7
Short access day 1 total inactive lever presses1.42.725.9-5.11.00.90.9-1.2-0.9-0.9-0.70.8-1.0-0.4-1.0-1.0
Short access day 10 total inactive lever presses0.10.61.10.7-1.0-1.1-0.80.80.70.70.5-0.70.80.40.60.9
Short access day 1 total infusions0.81.52.71.41.61.41.3-1.3-1.3-1.3-0.41.0-1.1-0.5-1.3-1.6
Short access day 10 total infusions1.32.15.72.41.61.61.4-1.5-1.4-1.4-0.81.2-1.3-0.9-1.2-1.5
Short access total infusions1.62.314.13.71.41.41.2-1.3-1.1-1.1-0.71.0-1.1-0.8-1.0-1.2
Short access day 1 locomotion0.30.61.21.10.90.80.7-0.8-0.8-0.8-0.30.6-0.8-0.5-0.6-0.9
Short access day 10 total locomotion1.25.063.58.00.50.30.4-0.1-0.3-0.30.10.3-0.1-0.3-0.1-0.4
Short access total locomotion1.42.125.55.00.40.40.4-0.3-0.4-0.4-0.00.3-0.3-0.3-0.3-0.4
One hour access (0.3 mA shock)1.21.413.83.70.80.80.6-0.5-0.7-0.7-0.10.5-0.6-0.3-0.8-0.8
Compulsive drug intake0.50.77.62.7-0.6-0.3-0.30.00.20.2-0.30.10.0-0.60.10.6
One hour access (shock baseline)0.20.61.3-0.81.10.90.8-0.6-0.8-0.8-0.00.4-0.70.0-0.9-1.2
Social response proportion0.91.211.93.5-0.5-0.3-0.50.40.60.60.5-0.50.60.30.70.6
Social responses0.20.30.60.8-0.6-0.4-0.60.30.70.70.4-0.50.40.40.50.7
Social time0.40.71.0-0.5-0.8-0.7-0.90.80.90.90.9-0.91.00.90.60.7
Soleus weight0.10.31.5-1.20.50.30.5-0.4-0.6-0.6-0.50.5-0.3-0.5-0.6-0.5
Bone: stiffness0.10.20.4-0.00.30.40.4-0.4-0.4-0.4-0.60.5-0.4-0.6-0.2-0.0
Tibialis anterior weight0.00.10.20.10.30.30.3-0.4-0.3-0.3-0.30.3-0.4-0.3-0.3-0.3
Time to tail flick, vehicle, before self-admin1.11.45.9-2.4-1.3-1.0-1.20.91.01.00.5-0.90.70.81.01.3
Time to tail flick, vehicle, after self-admin1.53.014.23.8-1.5-1.3-1.51.31.61.61.4-1.41.21.21.61.5
Time to tail flick, test, before self-admin2.93.34.71.0-1.8-2.0-1.81.91.81.81.9-1.92.21.91.81.6
Time to tail flick, test, after self-admin3.03.231.75.6-0.9-0.8-0.90.61.01.01.0-0.90.80.81.00.9
Delta time to tail flick, vehicle, before/after SA0.80.89.73.10.30.30.3-0.3-0.2-0.2-0.10.2-0.2-0.3-0.2-0.2
Delta time to tail flick, test, before/after SA1.62.023.94.90.30.50.3-0.6-0.2-0.2-0.20.3-0.6-0.5-0.2-0.1
Tibia length0.72.02.4-1.31.61.41.5-1.4-1.5-1.5-1.21.4-1.2-1.2-1.5-1.5
Ambulatory time before self-admin0.20.64.62.1-0.3-0.3-0.40.30.60.60.8-0.60.20.80.60.3
Ambulatory time after self-admin0.10.22.41.50.20.2-0.0-0.10.20.20.4-0.2-0.10.40.2-0.1
Bone: tissue strength0.80.91.4-1.20.90.90.9-0.9-0.9-0.9-1.01.0-0.8-1.0-1.0-0.7
Total heroin consumption0.60.75.32.3-0.7-0.2-0.40.20.70.7-0.4-0.10.1-0.50.71.1
Bone: trabecular number1.02.03.10.31.51.51.5-1.3-1.4-1.4-1.51.5-1.3-1.5-1.4-1.8
Bone: trabecular spacing0.30.41.2-1.0-0.3-0.5-0.40.40.40.40.7-0.60.40.70.41.1
Bone: trabecular thickness3.24.55.8-1.12.12.22.1-2.1-2.1-2.1-2.22.2-2.2-2.2-2.1-2.4
Bone: trabecular tissue density1.22.02.5-1.61.31.31.4-1.4-1.4-1.4-1.51.4-1.4-1.5-1.4-1.3
Water consumed over 24 hours0.10.20.50.5-0.7-0.4-0.50.40.50.5-0.2-0.20.3-0.20.50.5
Number of responses in last shaping day1.92.413.5-3.71.61.21.3-1.0-1.3-1.3-0.61.0-0.9-0.5-1.7-1.7