Hub : Genes

Mindy4b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr2_145189733_145190730 0.02 0.02 2.5e-03 0.01 0.01 0.02 0.01 2.2e-03 3.4e-03 1.1e-03 5.0e-03
2 BLA gene expression Mindy4b 0.38 0.19 1.8e-12 0.16 0.2 0.18 0.19 4.5e-09 1.1e-10 6.3e-10 2.8e-10
3 BLA mRNA stability Mindy4b 0.1 0.08 2.0e-04 0.05 0.06 0.05 0.06 1.3e-03 4.4e-04 1.6e-03 4.0e-04
4 IC gene expression Mindy4b 0.31 0.2 8.8e-10 0.14 0.18 0.15 0.16 1.5e-06 4.4e-08 8.0e-07 5.0e-07
5 NAcc mRNA stability Mindy4b 0.05 0.05 1.3e-05 0.03 0.03 0.03 0.03 8.7e-06 2.0e-05 2.9e-05 2.5e-05
6 PL mRNA stability Mindy4b 0.05 0.05 5.3e-05 0.04 0.03 0.02 0.03 9.4e-05 2.6e-04 1.1e-03 2.8e-04
7 PL intron excision ratio chr2_145189733_145190730 0.08 0.09 1.6e-04 0.03 0.03 0.03 0.03 1.6e-04 2.3e-04 3.5e-04 1.8e-04
8 pVTA gene expression Mindy4b 0.08 0.06 1.1e-06 0.09 0.08 0.08 0.08 2.0e-07 8.0e-07 5.1e-07 9.6e-07
9 Brain mRNA stability Mindy4b 0.02 0.03 7.4e-03 0.01 0.02 0.01 0.02 2.2e-02 3.7e-03 2.1e-02 5.3e-03
10 Brain gene expression Mindy4b 0.09 0.07 1.3e-08 0.09 0.09 0.09 0.09 6.7e-09 1.3e-08 1.6e-08 1.8e-08
11 OFC gene expression Mindy4b 0.24 0.19 6.4e-03 0.02 0.01 0.01 0.01 1.3e-01 2.0e-01 2.3e-01 2.1e-01
12 NAcc gene expression Mindy4b 0.13 0.11 5.6e-09 0.07 0.06 0.06 0.06 3.2e-10 3.6e-09 5.1e-10 4.2e-10
13 PL gene expression Mindy4b 0.38 0.19 0.0e+00 0.2 0.21 0.22 0.22 2.0e-21 4.9e-23 5.7e-24 3.7e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.81.42.4-0.61.11.31.21.11.11.11.31.21.11.31.11.5
Area under the delay curve3.74.410.4-3.2-2.2-2.0-2.1-2.1-2.1-2.1-1.6-1.9-1.8-1.6-1.8-2.2
BMI with tail2.69.039.2-6.3-2.7-2.6-2.6-2.6-2.6-2.6-2.3-2.4-2.7-2.2-2.7-2.6
BMI without tail2.26.817.0-4.1-2.7-2.5-2.6-2.4-2.5-2.5-2.1-2.4-2.3-2.0-2.5-2.7
Body weight2.19.028.9-5.4-2.8-2.7-2.8-2.7-2.7-2.7-2.7-2.8-2.7-2.6-2.8-2.5
Weight adjusted by age0.40.63.9-2.00.00.30.30.30.30.31.00.60.71.10.1-0.2
Bone surface0.20.33.6-1.9-0.4-0.2-0.3-0.3-0.3-0.30.0-0.2-0.20.0-0.40.0
Bone volume0.61.01.8-0.70.91.01.00.90.90.91.11.01.01.10.91.3
Breakpoint value in progressive ratio session0.00.10.2-0.3-0.2-0.1-0.2-0.1-0.3-0.30.1-0.0-0.10.1-0.3-0.5
Number of licking bursts0.20.33.9-2.0-0.1-0.1-0.1-0.3-0.1-0.10.0-0.00.00.0-0.30.1
Context. condit. distance diff. score0.70.81.10.90.80.90.90.90.90.91.00.91.11.00.90.8
Locomotion velocity, session 10.20.30.40.30.50.60.50.60.50.50.50.50.70.50.50.6
Locomotion distance, session 10.10.20.70.30.50.30.30.30.30.3-0.20.10.5-0.20.30.8
Locomotion velocity, session 24.75.57.02.62.42.32.32.42.32.32.12.32.52.12.32.6
Locomotion distance, session 20.20.31.51.20.60.50.50.50.50.50.10.30.70.10.50.6
Locomotion velocity, session 30.10.10.30.3-0.3-0.3-0.3-0.3-0.2-0.2-0.2-0.2-0.1-0.1-0.2-0.6
Locomotion distance, session 30.10.10.30.3-0.4-0.4-0.3-0.3-0.3-0.3-0.0-0.2-0.2-0.0-0.3-0.6
Stereotopy head waving bouts, day 30.80.91.20.61.11.01.00.91.01.00.81.00.90.91.01.1
Stereotopy head waving duration, day 30.91.11.31.01.11.11.11.01.11.10.91.01.00.91.11.1
Locomotion velocity, session 70.10.10.40.10.30.40.30.50.30.30.40.40.60.40.30.0
Locomotion distance, session 70.10.20.60.80.40.30.40.30.40.40.30.30.30.20.40.3
Stereotopy head waving bouts, day 70.40.50.90.10.60.80.70.80.60.60.90.80.80.90.60.5
Stereotopy head waving duration, day 70.10.20.50.10.30.40.30.60.30.30.60.50.50.70.30.1
Locomotion velocity, session 80.10.10.4-0.4-0.1-0.2-0.2-0.1-0.2-0.2-0.7-0.40.1-0.6-0.2-0.4
Locomotion distance, session 80.10.20.40.50.50.50.40.50.40.40.20.30.70.20.40.5
Degree of sensitization distance0.10.10.30.00.40.40.40.30.30.30.10.30.20.10.30.5
Degree of sensitization stereotypy0.40.40.70.50.60.70.60.80.50.50.80.70.80.80.50.4
Conditioned locomotion0.10.10.50.2-0.3-0.3-0.3-0.2-0.3-0.3-0.3-0.3-0.4-0.3-0.3-0.7
Cocaine response after cond. corrected1.62.04.1-2.0-1.4-1.3-1.4-1.4-1.4-1.4-1.3-1.4-1.0-1.3-1.3-1.3
Cocaine response after cond. not corrected1.92.33.5-1.9-1.7-1.4-1.6-1.5-1.6-1.6-1.3-1.5-1.2-1.3-1.4-1.5
Cocaine response before conditioning0.40.52.61.60.30.50.40.60.40.40.80.60.50.80.60.1
Saline control response0.71.01.40.1-1.1-1.0-1.1-0.9-1.1-1.1-0.9-1.0-1.1-0.9-0.9-1.2
Bone: connectivity density0.20.44.1-2.0-0.2-0.2-0.2-0.4-0.2-0.2-0.2-0.2-0.4-0.2-0.30.2
Bone: cortical apparent density4.25.86.72.32.32.42.42.22.42.42.62.52.22.62.52.4
Bone: cortical area0.10.10.80.9-0.10.00.10.10.10.10.40.2-0.00.40.2-0.3
Bone: cortical porosity0.10.10.3-0.3-0.2-0.2-0.3-0.2-0.3-0.3-0.5-0.4-0.1-0.5-0.3-0.2
Bone: cortical porosity0.40.50.6-0.5-0.7-0.6-0.7-0.6-0.8-0.8-0.7-0.7-0.5-0.7-0.7-0.8
Bone: cortical thickness1.32.16.72.61.21.31.31.41.31.31.51.41.21.51.40.7
Bone: cortical thickness0.10.10.90.9-0.1-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.2-0.1-0.0-0.4
Bone: cortical tissue density3.75.05.82.12.12.22.22.12.32.32.42.32.02.42.42.3
Condit. Reinf. active minus inactive responses6.27.011.8-3.4-2.3-2.6-2.5-2.7-2.5-2.5-3.0-2.7-2.5-2.9-2.5-2.0
Condit. Reinf. active-inactive response ratio5.55.910.9-3.3-2.0-2.3-2.2-2.5-2.2-2.2-2.9-2.5-2.4-2.8-2.2-1.6
Condit. Reinf. active responses8.210.112.6-3.1-3.0-3.2-3.2-3.3-3.1-3.1-3.5-3.3-3.1-3.6-3.1-2.7
Condit. Reinf. inactive responses2.02.53.4-0.5-1.7-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.5-1.7-1.6-1.8
Incentive salience index mean2.73.34.8-1.8-1.6-1.8-1.8-2.0-1.7-1.7-2.2-1.9-1.9-2.2-1.7-1.3
Condit. Reinf. lever presses0.00.10.30.5-0.1-0.2-0.1-0.3-0.1-0.1-0.3-0.2-0.2-0.4-0.10.1
Condit. Reinf. active minus inactive responses1.72.22.6-1.3-1.6-1.5-1.5-1.5-1.5-1.5-1.4-1.5-1.6-1.4-1.5-1.5
Condit. Reinf. active-inactive response ratio2.42.86.6-2.6-1.7-1.6-1.6-1.8-1.6-1.6-1.4-1.5-1.6-1.4-1.6-1.4
Condit. Reinf. active responses0.30.40.50.6-0.7-0.7-0.6-0.6-0.6-0.6-0.5-0.6-0.6-0.5-0.5-0.7
Condit. Reinf. inactive responses0.81.06.92.60.80.70.70.90.70.70.60.70.80.60.80.5
Condit. Reinf. lever presses2.53.54.2-0.3-1.9-2.0-2.0-1.8-2.0-2.0-2.0-2.0-1.9-2.0-1.9-1.9
Condit. Reinf. lever reinforcers received0.20.30.60.8-0.6-0.6-0.6-0.5-0.6-0.6-0.4-0.5-0.5-0.4-0.5-0.7
Conditioned reinforcement - actives1.12.07.0-2.61.41.41.31.31.31.30.71.11.30.91.31.3
Conditioned reinforcement - inactives0.40.54.7-2.2-0.1-0.2-0.3-0.2-0.3-0.3-0.7-0.5-0.2-0.7-0.5-0.1
Conditioned locomotion2.73.536.1-6.01.11.11.00.81.01.00.40.80.90.70.81.0
Patch foraging indifference point 0 sec0.20.41.71.30.10.40.30.50.30.30.90.50.70.90.2-0.0
Patch foraging indifference point AUC0.10.20.60.80.50.30.30.30.30.3-0.20.10.3-0.30.50.6
Delay disc. indifference point, 0s delay2.32.611.6-3.4-1.5-1.4-1.4-1.4-1.4-1.4-1.2-1.3-1.4-1.1-1.3-1.4
Delay disc. indifference point, 16s delay5.96.510.3-3.2-2.6-2.6-2.6-2.6-2.5-2.5-2.4-2.5-2.5-2.3-2.3-2.4
Delay disc. indifference point, 2s delay1.71.912.1-3.5-1.0-0.9-1.0-1.1-1.0-1.0-1.1-1.0-1.2-1.0-0.9-0.9
Delay disc. indifference point, 24s delay1.51.62.3-0.4-1.5-1.5-1.4-1.5-1.3-1.4-1.2-1.3-1.3-1.2-1.0-1.2
Delay disc. indifference point, 4s delay2.12.217.7-4.2-1.1-0.9-1.0-1.0-1.0-1.0-0.8-0.9-1.0-0.7-0.9-1.1
Delay disc. indifference point, 8s delay1.41.62.5-1.4-1.6-1.4-1.4-1.3-1.4-1.3-0.9-1.2-1.0-0.8-1.1-1.6
Indifference point function ln k0.81.53.3-1.8-1.4-1.2-1.2-1.1-1.2-1.2-0.7-1.0-1.1-0.6-1.4-1.4
Indifference point function log k0.81.53.3-1.8-1.4-1.2-1.2-1.1-1.2-1.2-0.7-1.0-1.1-0.6-1.4-1.4
Patch foraging total patch changes 0 sec0.10.32.31.5-0.20.10.00.20.10.10.50.20.40.60.1-0.1
Patch foraging total patch changes 12 sec1.11.42.00.81.31.21.21.21.21.21.11.21.41.11.21.1
Patch foraging total patch changes 18 sec0.30.51.4-1.20.70.80.60.90.50.50.50.60.90.50.50.4
Patch foraging total patch changes 24 sec0.61.07.52.70.60.70.60.80.60.60.90.70.90.80.80.4
Patch foraging total patch changes 6 sec0.61.09.33.00.10.40.30.50.20.20.90.51.00.80.5-0.1
Patch foraging time to switch 0 sec0.71.42.0-0.11.11.31.21.31.11.11.41.31.41.41.10.8
Patch foraging water rate 0 sec0.51.11.4-1.1-1.2-1.1-1.1-1.1-1.0-1.0-1.0-1.1-1.0-0.9-1.0-1.0
Patch foraging water rate 12 sec0.40.81.9-1.10.60.60.70.60.90.91.10.90.81.40.90.5
Patch foraging water rate 18 sec0.10.10.50.1-0.5-0.4-0.4-0.7-0.2-0.2-0.0-0.2-0.5-0.1-0.2-0.4
Patch foraging water rate 24 sec0.60.94.12.00.70.70.70.60.90.90.80.70.70.80.90.8
Patch foraging water rate 6 sec0.30.51.2-1.1-0.9-0.8-0.8-0.6-0.7-0.7-0.2-0.5-0.4-0.1-0.8-1.0
Seeking ratio, delayed vs. immediate footshock2.53.118.04.21.01.11.21.41.51.41.71.41.41.61.41.0
Distance traveled before self-admin0.20.21.8-1.30.30.20.10.30.00.0-0.5-0.10.3-0.50.00.3
Distance traveled after self-admin0.20.31.6-1.3-0.1-0.2-0.3-0.2-0.4-0.4-0.7-0.5-0.3-0.8-0.4-0.1
Extensor digitorum longus weight1.97.311.2-3.3-2.7-2.6-2.7-2.6-2.7-2.7-2.6-2.7-2.6-2.6-2.7-2.5
Bone: elastic displacement0.10.10.50.70.50.40.40.30.40.40.10.30.20.10.50.3
Bone: elastic work0.60.82.81.70.90.80.80.80.80.80.60.70.70.61.00.5
Bone: endosteal estimation1.43.06.8-2.6-1.7-1.7-1.7-1.8-1.7-1.7-1.4-1.6-1.7-1.4-1.7-1.3
Bone: endosteal perimeter0.71.64.8-2.2-1.1-1.2-1.2-1.3-1.2-1.2-1.2-1.2-1.2-1.2-1.2-0.7
Epididymis fat weight0.31.01.81.3-0.8-1.0-0.9-0.9-0.9-0.9-1.2-1.0-1.0-1.2-0.8-0.6
Delta time in closed arm before/after self-admin0.20.20.2-0.40.50.40.40.30.50.50.30.40.50.30.50.5
Delta time in open arm before/after self-admin0.40.41.11.00.90.60.70.50.70.70.20.50.30.10.71.1
Diff in mean of infusions in LGA sessions0.40.56.1-2.50.10.1-0.1-0.0-0.3-0.3-0.4-0.2-0.1-0.4-0.3-0.0
Delay discount exponential model param3.23.69.43.12.01.81.91.91.81.91.51.71.71.41.61.9
Extinction: sum of active levers before priming1.41.57.9-2.8-1.1-1.1-1.0-1.2-1.0-1.0-1.0-1.0-0.9-0.8-1.0-1.0
Active lever presses in extinction session 60.60.61.70.8-0.9-0.6-0.8-0.3-1.0-1.0-0.1-0.5-0.1-0.2-1.0-1.3
Bone: final force0.10.20.50.70.20.30.30.40.30.30.70.50.20.70.3-0.0
Bone: final moment0.10.20.90.90.20.30.30.40.30.30.70.50.20.70.40.2
Food consumed during 24 hour testing period0.81.12.1-0.2-1.4-1.2-1.2-1.0-1.2-1.2-0.6-1.0-1.0-0.6-1.2-1.4
Glucose2.94.65.6-2.1-2.0-2.2-2.1-2.3-2.0-2.0-2.4-2.2-2.4-2.3-2.0-1.6
Heart weight0.10.22.11.4-0.2-0.2-0.2-0.0-0.3-0.3-0.0-0.1-0.20.0-0.0-0.4
Delay discount hyperbolic model param3.74.113.83.72.01.81.92.01.91.91.61.81.81.51.71.9
Intermittent access intake day 1-15 change1.12.226.35.10.70.60.50.50.50.50.30.30.3-0.20.60.8
Intermittent access intake escalation1.22.428.65.30.70.60.50.50.50.50.30.30.3-0.20.50.8
Intermittent access intake escalation 20.50.66.82.60.30.30.1-0.20.00.0-0.2-0.1-0.3-0.60.00.4
Intermitt. access day 1 inactive lever presses0.41.42.31.1-1.1-1.2-1.2-1.3-1.1-1.1-1.4-1.3-1.3-1.5-0.7-0.8
Intermitt. access day 15 inactive lever presses0.10.20.90.10.2-0.1-0.1-0.3-0.1-0.1-0.9-0.5-0.7-0.90.10.5
Intermitt. access escalation Index1.62.321.34.61.21.00.90.90.80.80.50.70.80.30.81.1
Intermittent access day 1 total infusions0.91.416.8-4.10.50.50.40.40.40.4-0.10.20.30.00.20.6
Intermittent access day 15 total infusions0.20.30.80.40.80.70.50.40.50.5-0.10.20.3-0.30.50.9
Intermittent access terminal intake (last 3 days)0.10.20.50.40.60.50.30.20.30.3-0.3-0.00.1-0.50.30.7
Intermittent access total infusions0.50.61.20.41.11.00.80.80.80.80.20.50.70.20.81.1
Intermittent access day 1 locomotion1.01.316.7-4.10.10.1-0.0-0.0-0.1-0.1-0.6-0.2-0.2-0.4-0.20.1
Intermittent access day 15 total locomotion0.40.82.1-1.4-0.7-0.6-0.8-0.8-0.8-0.8-1.0-0.9-0.8-1.2-0.8-0.6
Intermittent access total locomotion1.11.417.1-4.10.10.0-0.0-0.2-0.1-0.1-0.6-0.2-0.2-0.4-0.00.2
Intermittent access standard deviation0.20.51.0-1.00.90.70.80.40.80.80.40.60.40.40.71.0
Left kidney weight0.21.113.0-3.6-0.00.30.10.5-0.0-0.10.40.30.70.6-0.0-0.3
Right kidney weight0.10.51.20.70.50.70.61.00.50.50.90.71.11.00.50.3
Cocaine induced anxiety0.40.65.4-2.3-0.1-0.2-0.2-0.3-0.3-0.3-0.9-0.4-0.4-0.6-0.2-0.1
Post-drug Anxiety0.10.21.5-1.20.30.30.20.20.10.1-0.10.10.20.00.30.2
Baseline Anxiety1.21.47.12.70.81.00.91.00.90.91.21.01.01.11.00.7
Tail length0.20.81.31.1-1.1-0.8-1.0-0.6-0.9-0.9-0.6-0.9-0.4-0.7-1.1-1.1
Length with tail0.31.11.5-0.8-1.1-1.1-1.2-1.0-1.0-1.0-1.2-1.2-0.9-1.2-1.2-0.8
Length without tail0.72.314.0-3.7-0.9-1.1-1.1-1.2-1.0-1.1-1.5-1.2-1.3-1.4-1.2-0.6
Times rat made contact with spout0.10.10.30.60.30.30.30.30.30.30.30.30.30.30.40.5
Lifetime Intake1.01.22.1-1.41.31.31.11.21.11.10.50.91.00.61.01.3
Liver weight, left0.30.66.2-2.50.30.20.40.30.30.20.30.40.20.50.20.2
Liver weight, right1.42.57.32.71.61.51.51.51.51.51.31.41.21.21.41.6
Locomotor activity1.32.12.60.3-1.5-1.4-1.5-1.3-1.6-1.6-1.5-1.5-1.5-1.6-1.5-1.5
Locomotor testing distance4.37.89.6-1.4-2.8-2.8-2.9-2.7-2.9-2.9-3.0-2.9-3.0-3.1-2.8-2.6
Locomotor testing rearing0.61.27.32.7-0.8-0.9-0.9-0.8-0.7-0.7-1.0-0.9-0.8-1.1-0.5-0.5
Locomotion in novel chamber0.91.26.02.51.21.01.01.00.80.80.30.70.90.20.81.1
Locomotion in novel chamber post-restriction0.91.49.03.00.80.90.81.10.90.90.90.91.00.80.90.7
Fecal boli incidents, locomotor time 10.81.14.4-2.1-0.6-0.9-0.8-0.9-0.7-0.7-1.5-1.1-1.1-1.3-0.7-0.2
Change in fecal boli incidents, locomotor task1.41.314.13.80.20.40.40.60.50.40.90.60.70.60.40.1
Time >=10cm from walls, locomotor time 12.42.626.45.10.50.50.70.70.80.81.10.80.81.10.80.6
Bouts of movement, locomotor time 11.41.63.21.81.01.01.11.21.21.21.41.21.41.41.20.9
Total resting periods, locomotor time 12.32.63.81.21.41.51.51.71.71.61.81.71.72.01.71.3
Rest time, locomotor task time 12.43.14.30.81.71.81.81.81.91.81.91.81.62.11.91.6
Distance moved, locomotor task time 10.81.21.9-0.4-1.0-1.1-1.1-1.1-1.1-1.1-1.3-1.2-1.2-1.4-1.1-0.9
Vertical activity count, locomotor time 10.20.40.70.0-0.5-0.6-0.6-0.6-0.7-0.6-0.8-0.7-0.6-0.9-0.7-0.4
Time >=10cm from walls, locomotor time 23.55.246.56.81.31.21.31.41.41.31.31.31.41.21.31.4
Bouts of movement, locomotor time 22.64.221.94.71.11.51.41.81.41.42.21.72.32.01.30.7
Total resting periods, locomotor time 21.83.112.53.51.01.41.31.71.21.22.11.62.22.01.20.6
Rest time, locomotor task time 20.70.93.5-1.90.60.90.70.80.70.61.20.90.91.40.60.3
Distance moved, locomotor task time 21.11.316.14.0-0.2-0.3-0.2-0.1-0.2-0.2-0.3-0.3-0.2-0.5-0.1-0.1
Vertical activity count, locomotor time 22.33.234.15.80.90.80.80.90.80.80.70.70.90.40.90.9
Light reinforcement 11.64.013.3-3.7-1.7-1.8-1.8-1.9-1.8-1.8-1.9-1.9-2.0-1.8-1.5-1.5
Light reinforcement 20.50.88.4-2.9-0.4-0.4-0.4-0.4-0.5-0.5-0.4-0.4-0.7-0.3-0.4-0.4
Bone: marrow area1.12.56.0-2.5-1.6-1.5-1.5-1.7-1.5-1.5-1.3-1.4-1.6-1.3-1.5-1.1
Bone: maximum diameter0.00.00.1-0.1-0.10.00.0-0.1-0.0-0.00.30.10.10.30.1-0.0
Bone: maximum force0.10.10.3-0.2-0.4-0.3-0.3-0.4-0.3-0.3-0.1-0.2-0.5-0.1-0.3-0.5
Bone: maximum moment0.00.10.20.1-0.3-0.3-0.3-0.3-0.3-0.3-0.0-0.2-0.5-0.0-0.2-0.3
Mean time between licks in bursts1.53.75.0-0.2-1.8-2.0-1.9-2.0-1.9-1.9-2.2-2.0-2.1-2.2-1.6-2.1
Mean num. licks in bursts0.30.44.92.20.10.20.10.40.10.10.20.10.10.20.40.0
Cd content in liver0.70.71.10.60.90.90.81.00.80.80.80.81.00.80.80.9
Co content in liver1.51.83.2-0.8-1.7-1.4-1.5-1.3-1.5-1.5-0.9-1.2-1.1-0.9-1.5-1.8
Cu content in liver1.11.31.9-0.9-1.2-1.2-1.2-1.1-1.2-1.2-1.0-1.1-1.1-1.0-1.2-1.4
Fe content in liver0.00.00.00.20.20.10.20.10.20.20.10.10.00.10.20.0
K content in liver0.20.20.80.90.30.30.40.30.40.40.70.50.20.70.40.4
Mg content in liver0.20.20.5-0.0-0.6-0.5-0.5-0.6-0.5-0.5-0.2-0.4-0.7-0.2-0.5-0.4
Mn content in liver0.00.00.10.3-0.3-0.2-0.2-0.3-0.2-0.20.1-0.1-0.20.1-0.2-0.2
Na content in liver0.10.10.50.70.10.20.20.30.20.20.50.30.20.50.2-0.1
Rb content in liver4.04.75.8-1.8-2.2-2.2-2.2-2.2-2.2-2.2-2.0-2.1-2.2-2.0-2.2-2.4
Se content in liver0.00.00.10.10.20.20.20.20.20.20.20.20.20.20.20.1
Sr content in liver1.11.01.20.91.01.01.01.01.01.00.91.01.00.91.01.1
Zn content in liver0.40.51.3-1.1-0.5-0.6-0.6-0.6-0.6-0.6-0.8-0.7-0.7-0.8-0.6-0.3
Bone: minimum diameter1.83.33.8-1.5-1.8-1.9-1.8-1.9-1.8-1.8-1.9-1.9-1.9-1.9-1.8-1.8
Time in familiar zone, hab. session 11.61.52.51.31.01.21.11.31.11.11.61.31.31.51.11.0
Time in novel zone, hab. session 10.60.61.4-0.9-0.5-0.6-0.6-0.8-0.6-0.6-1.2-0.9-0.9-1.2-0.6-0.5
Total zone transitions, hab. session 11.01.42.0-0.4-1.1-1.2-1.2-1.1-1.3-1.3-1.4-1.3-1.0-1.4-1.3-1.3
Total locomotion distance, hab. session 10.40.60.8-0.2-0.7-0.8-0.8-0.7-0.8-0.8-0.9-0.8-0.7-0.9-0.8-0.8
Locomotion velocity, hab. session 10.40.60.8-0.2-0.7-0.8-0.8-0.7-0.8-0.8-0.9-0.8-0.6-0.9-0.8-0.8
Time in familiar zone, hab. session 22.72.93.61.41.51.71.61.71.71.71.91.81.81.91.71.6
Time in novel zone, hab. session 22.62.63.4-1.3-1.5-1.6-1.6-1.6-1.6-1.6-1.9-1.7-1.7-1.9-1.6-1.6
Total zone transitions, hab. session 20.20.31.21.10.60.40.40.50.40.4-0.00.20.6-0.10.40.5
Total locomotion distance, hab. session 20.30.40.70.4-0.6-0.7-0.7-0.6-0.7-0.7-0.8-0.7-0.5-0.8-0.7-0.5
Locomotion velocity, hab. session 20.20.30.80.9-0.4-0.5-0.5-0.4-0.4-0.4-0.6-0.6-0.3-0.7-0.5-0.3
Novel to familiar place preference ratio0.00.00.2-0.40.30.30.30.10.20.20.00.20.00.00.20.1
Novelty place preference0.20.20.3-0.20.60.50.50.40.50.50.20.40.30.20.50.3
Time in novel zone, NPP test0.20.20.3-0.40.60.60.50.40.50.50.20.40.30.20.50.3
Total zone transitions, NPP test0.10.10.40.4-0.2-0.3-0.3-0.3-0.3-0.3-0.6-0.4-0.1-0.6-0.3-0.4
Total locomotion distance, NPP test0.00.00.10.1-0.0-0.1-0.1-0.1-0.1-0.1-0.3-0.20.0-0.4-0.1-0.2
Locomotion velocity, NPP test0.00.00.10.40.0-0.1-0.1-0.1-0.1-0.1-0.3-0.2-0.0-0.4-0.1-0.1
Intraocular pressure0.81.24.82.2-0.7-0.9-0.9-1.0-0.7-0.8-1.3-1.1-1.1-1.3-0.6-0.2
Delta distance traveled before/after self-admin0.50.51.81.40.60.60.60.50.70.70.70.60.50.60.70.6
Delta ambulatory time before/after self-admin0.10.10.10.10.30.40.30.30.30.30.30.30.30.40.30.3
Parametrial fat weight0.51.21.4-1.0-1.1-1.2-1.1-1.1-1.2-1.2-1.2-1.2-1.1-1.1-1.0-1.0
Pavlov. Cond. lever latency0.60.81.9-1.4-0.7-0.7-0.8-0.6-0.8-0.8-1.1-0.9-0.7-1.0-0.8-0.6
Pavlov. Cond. magazine entry latency0.10.10.50.7-0.2-0.1-0.00.00.00.00.50.2-0.10.50.0-0.0
Pavlov. Cond. change in total contacts0.30.31.51.20.40.40.40.30.50.50.50.50.50.50.50.4
Pavlov. Cond. index score1.31.64.02.00.91.01.11.01.21.21.61.31.11.61.21.0
Pavlov. Cond. latency score1.11.33.01.70.80.91.00.91.11.11.51.20.91.51.11.0
Pavlov. Cond. lever contacts0.40.51.11.10.50.50.60.50.70.70.90.70.60.90.60.5
Pavlov. Cond. magazine entry number0.40.51.9-1.4-0.3-0.5-0.5-0.5-0.6-0.6-1.0-0.7-0.6-1.1-0.6-0.3
Pavlov. Cond. intertrial magazine entries0.81.02.2-1.5-0.7-0.8-0.9-0.9-0.9-0.9-1.3-1.0-0.7-1.3-0.9-0.8
Pavlov. Cond. lever-magazine prob. diff.1.41.84.12.01.01.11.21.11.21.21.61.31.11.61.21.1
Pavlov. Cond. response bias0.60.72.31.50.50.60.70.60.70.71.10.80.71.10.70.4
Pavlov. Cond. lever latency0.81.11.2-0.11.11.11.10.91.11.11.11.11.01.11.01.1
Pavlov. Cond. magazine entry latency0.10.10.10.4-0.3-0.3-0.3-0.2-0.3-0.3-0.3-0.3-0.1-0.3-0.2-0.3
Pavlov. Cond. change in total contacts0.71.11.40.4-1.2-1.2-1.1-1.1-1.1-1.1-1.1-1.1-1.0-1.1-1.0-1.2
Pavlov. Cond. index score0.81.11.30.2-1.1-1.1-1.1-0.9-1.1-1.1-1.2-1.1-0.9-1.2-1.0-1.1
Pavlov. Cond. latency score1.11.41.8-0.1-1.2-1.3-1.3-1.1-1.3-1.3-1.3-1.3-1.1-1.3-1.2-1.2
Pavlov. Cond. lever contacts0.50.70.80.2-0.9-0.9-0.9-0.7-0.9-0.9-0.9-0.9-0.8-0.9-0.8-0.9
Pavlov. Cond. magazine entry number0.50.60.70.40.80.80.90.80.90.90.90.90.60.90.80.8
Pavlov. Cond. intertrial magazine entries0.40.50.60.80.80.70.80.70.80.80.70.80.60.70.70.7
Pavlov. Cond. lever-magazine prob. diff.0.81.01.20.2-1.1-1.1-1.1-0.9-1.1-1.1-1.1-1.1-0.9-1.1-1.0-1.0
Pavlov. Cond. response bias0.40.60.80.4-0.8-0.8-0.8-0.6-0.8-0.8-0.8-0.8-0.7-0.8-0.7-0.9
Time in closed arm before self-admin1.31.62.0-0.81.31.21.31.21.41.41.31.31.11.41.41.4
Time in closed arm after self-admin0.80.81.5-1.01.10.90.90.81.01.00.40.70.70.51.01.2
Time in open arm before self-admin5.05.57.52.7-2.6-2.4-2.4-2.1-2.5-2.5-1.7-2.2-1.8-1.9-2.5-2.7
Time in open arm after self-admin0.80.94.72.2-0.9-0.9-0.8-0.7-0.8-0.8-0.4-0.6-0.6-0.4-0.8-1.0
Bone: periosteal estimation0.61.21.7-1.3-1.2-1.2-1.1-1.2-1.1-1.1-0.8-1.0-1.2-0.8-1.1-1.0
Bone: periosteal perimeter0.10.11.5-1.2-0.2-0.1-0.1-0.3-0.1-0.10.20.0-0.20.2-0.10.1
Bone: post-yield work3.65.38.0-2.8-2.3-2.3-2.3-2.3-2.3-2.3-2.1-2.2-2.4-2.1-2.3-2.3
Progressive ratio test 1 active lever presses1.21.52.51.61.41.41.21.41.31.30.81.01.00.71.21.4
Progressive ratio test 1 breakpoint1.31.62.31.11.51.51.31.51.31.30.81.11.10.81.21.4
Progressive ratio test 1 inactive lever presses0.10.20.5-0.50.0-0.3-0.2-0.3-0.1-0.1-0.7-0.4-0.7-0.7-0.30.2
Progressive ratio test 2 active lever presses0.70.810.0-3.20.20.30.10.20.10.1-0.10.10.2-0.00.00.1
Progressive ratio test 2 breakpoint0.81.012.4-3.50.00.2-0.00.10.00.0-0.2-0.00.1-0.1-0.1-0.0
Progressive ratio test 2 inactive lever presses0.30.51.7-1.3-0.4-0.4-0.5-0.6-0.5-0.5-0.9-0.7-0.7-0.9-0.5-0.3
Incentive Sensitization - Responses2.12.928.9-5.4-1.0-0.8-0.9-0.9-0.9-0.9-0.8-0.8-0.6-0.6-0.9-1.0
Incentive Sensitization - Breakpoint2.22.929.3-5.4-1.0-0.8-0.9-0.9-0.9-0.9-0.8-0.8-0.6-0.7-0.9-1.0
Sum of active levers in priming session hrs 5-60.80.72.6-1.6-0.7-0.7-0.7-0.6-0.9-0.9-0.9-0.8-0.5-0.8-0.9-0.8
Progressive ratio0.50.86.7-2.6-0.8-0.4-0.6-0.6-0.6-0.6-0.1-0.4-0.6-0.0-0.6-0.9
Food seeking constrained by brief footshock1.21.45.7-2.4-1.3-1.1-1.2-1.0-1.1-1.0-0.5-0.9-1.0-0.5-1.1-1.4
Seeking ratio, punishment vs. effort0.10.20.30.2-0.5-0.6-0.5-0.4-0.4-0.4-0.6-0.5-0.3-0.6-0.4-0.4
Retroperitoneal fat weight2.18.910.1-3.2-3.0-3.2-3.0-2.9-2.9-3.0-2.9-3.0-2.9-2.8-3.1-2.7
Reaction time number correct0.30.60.80.50.80.80.80.70.70.70.60.70.90.80.90.8
Reaction time mean minus median5.413.416.9-1.5-4.1-3.9-4.0-3.7-3.9-3.9-3.4-3.8-3.4-3.5-3.8-3.9
Reaction time mean minus median AUC5.313.516.8-1.3-4.1-4.0-4.0-3.8-3.9-3.9-3.5-3.8-3.5-3.6-3.7-3.8
Reaction time num false alarms3.14.45.61.3-2.2-2.4-2.2-2.1-2.1-2.1-2.1-2.2-2.2-2.2-2.2-1.9
Reaction time num false alarms AUC1.92.93.61.7-1.8-1.9-1.8-1.6-1.6-1.6-1.6-1.7-1.7-1.7-1.8-1.5
Reaction time trials correct on left0.30.60.80.50.80.80.80.70.70.70.60.70.90.80.90.8
Reaction time trials on left0.20.40.60.30.70.60.60.50.60.60.50.60.70.60.80.7
Reaction time mean8.213.046.1-6.8-3.4-3.3-3.3-3.3-3.3-3.3-2.9-3.1-3.2-2.7-3.2-3.4
Reaction time mean AUC8.213.242.3-6.5-3.5-3.4-3.4-3.4-3.3-3.3-3.0-3.2-3.3-2.8-3.3-3.4
Median of all reaction times7.110.155.1-7.4-2.7-2.6-2.6-2.6-2.6-2.6-2.3-2.4-2.6-2.0-2.6-2.7
Reaction time omissions11.516.822.9-4.8-4.0-4.2-4.0-4.3-3.9-3.9-4.3-4.1-4.3-4.3-3.8-3.4
Reaction time false alarm rate2.63.54.41.2-2.0-2.1-2.0-1.8-1.8-1.8-1.8-1.9-2.0-1.9-2.0-1.8
Reaction time premature initiation rate1.52.012.43.50.61.10.81.20.80.81.61.21.61.40.80.2
Reaction time premature initiations1.32.310.93.30.81.21.01.40.90.91.71.31.91.61.00.4
Std. dev. reaction times8.315.417.7-3.7-4.2-4.1-4.1-4.0-4.0-4.0-3.6-3.9-3.8-3.6-3.9-4.0
Reaction time trials completed0.20.40.60.30.70.60.60.50.60.60.50.60.70.60.80.7
Reaction time trials AUC0.20.40.60.10.70.60.70.50.60.60.40.60.70.60.80.7
Run reversals in cocaine runway, females0.40.45.12.30.30.10.20.00.30.3-0.00.10.1-0.00.20.5
Run reversals in cocaine runway, males0.30.30.80.10.70.60.50.50.50.5-0.00.30.3-0.00.60.9
Latency to leave start box in cocaine runway0.30.44.72.20.10.10.00.10.10.1-0.0-0.00.2-0.2-0.00.1
Latency to leave start box in cocaine runway, F1.31.410.53.20.90.90.80.80.90.90.70.70.80.50.81.0
Latency to leave start box in cocaine runway, M1.41.33.7-1.9-1.2-1.1-1.1-1.0-1.1-1.1-0.9-1.0-0.8-0.9-1.4-1.2
Std. dev. time between licks in bursts6.38.510.5-2.0-3.0-2.9-3.0-3.0-3.0-3.0-3.0-3.0-3.0-3.0-2.8-3.2
Total sessions with >9 infusions1.61.922.1-4.70.70.60.50.60.50.5-0.10.30.40.10.40.7
Short access day 1 total inactive lever presses2.23.028.75.41.00.90.91.20.90.90.70.81.00.41.01.0
Short access day 10 total inactive lever presses0.20.61.1-0.6-1.0-1.1-0.8-0.8-0.7-0.7-0.5-0.7-0.8-0.4-0.6-0.9
Short access day 1 total infusions1.21.62.7-1.61.61.41.31.31.31.30.41.01.10.51.31.6
Short access day 10 total infusions1.72.27.5-2.71.61.61.41.51.41.40.81.21.30.91.21.5
Short access total infusions2.02.517.3-4.21.41.41.21.31.11.10.71.01.10.81.01.2
Short access day 1 locomotion0.50.61.5-1.20.90.80.70.80.80.80.30.60.80.50.60.9
Short access day 10 total locomotion3.05.671.5-8.50.50.30.40.10.30.3-0.10.30.10.30.10.4
Short access total locomotion1.92.328.9-5.40.40.40.40.30.40.40.00.30.30.30.30.4
One hour access (0.3 mA shock)1.41.716.6-4.10.80.80.60.50.70.70.10.50.60.30.80.8
Compulsive drug intake0.60.77.7-2.8-0.6-0.3-0.3-0.0-0.2-0.20.30.1-0.00.6-0.1-0.6
One hour access (shock baseline)0.40.61.30.61.10.90.80.60.80.80.00.40.7-0.00.91.2
Social response proportion1.11.313.4-3.7-0.5-0.3-0.5-0.4-0.6-0.6-0.5-0.5-0.6-0.3-0.7-0.6
Social responses0.20.30.6-0.8-0.6-0.4-0.6-0.3-0.7-0.7-0.4-0.5-0.4-0.4-0.5-0.7
Social time0.50.71.00.5-0.8-0.7-0.9-0.8-0.9-0.9-0.9-0.9-1.0-0.9-0.6-0.7
Soleus weight0.10.31.61.30.50.30.50.40.60.60.50.50.30.50.60.5
Bone: stiffness0.10.20.4-0.00.30.40.40.40.40.40.60.50.40.60.20.0
Tibialis anterior weight0.00.10.2-0.20.30.30.30.40.30.30.30.30.40.30.30.3
Time to tail flick, vehicle, before self-admin1.41.57.32.7-1.3-1.0-1.2-0.9-1.0-1.0-0.5-0.9-0.7-0.8-1.0-1.3
Time to tail flick, vehicle, after self-admin2.33.014.5-3.8-1.5-1.3-1.5-1.3-1.6-1.6-1.4-1.4-1.2-1.2-1.6-1.5
Time to tail flick, test, before self-admin3.23.34.7-0.9-1.8-2.0-1.8-1.9-1.8-1.8-1.9-1.9-2.2-1.9-1.8-1.6
Time to tail flick, test, after self-admin3.43.535.8-6.0-0.9-0.8-0.9-0.6-1.0-1.0-1.0-0.9-0.8-0.8-1.0-0.9
Delta time to tail flick, vehicle, before/after SA0.90.910.9-3.30.30.30.30.30.20.20.10.20.20.30.20.2
Delta time to tail flick, test, before/after SA2.22.327.9-5.30.30.50.30.60.20.20.20.30.60.50.20.1
Tibia length0.71.92.41.31.61.41.51.41.51.51.21.41.21.21.51.5
Ambulatory time before self-admin0.40.75.4-2.3-0.3-0.3-0.4-0.3-0.6-0.6-0.8-0.6-0.2-0.8-0.6-0.3
Ambulatory time after self-admin0.20.33.0-1.70.20.2-0.00.1-0.2-0.2-0.4-0.20.1-0.4-0.20.1
Bone: tissue strength0.90.91.41.20.90.90.90.90.90.91.01.00.81.01.00.7
Total heroin consumption0.60.75.8-2.4-0.7-0.2-0.4-0.2-0.7-0.70.4-0.1-0.10.5-0.7-1.1
Bone: trabecular number1.22.03.1-0.41.51.51.51.31.41.41.51.51.31.51.41.8
Bone: trabecular spacing0.30.41.21.0-0.3-0.5-0.4-0.4-0.4-0.4-0.7-0.6-0.4-0.7-0.4-1.1
Bone: trabecular thickness3.64.45.81.02.12.22.12.12.12.12.22.22.22.22.12.4
Bone: trabecular tissue density1.42.02.61.61.31.31.41.41.41.41.51.41.41.51.41.3
Water consumed over 24 hours0.10.20.5-0.4-0.7-0.4-0.5-0.4-0.5-0.50.2-0.2-0.30.2-0.5-0.5
Number of responses in last shaping day2.32.514.33.81.61.21.31.01.31.30.61.00.90.51.71.7