Hub : Genes

Midn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC isoform ratio XM_006240912.4 0.13 0.09 4.5e-03 0.07 0.09 0.08 0.08 8.5e-03 4.7e-03 5.7e-03 7.4e-03
2 Liver mRNA stability Midn 0.03 0.02 5.0e-03 0.02 0.01 0.01 0.02 3.8e-03 9.9e-03 1.5e-02 5.3e-03
3 PL alternative TSS XM_006240912.4 0.04 0.03 4.4e-06 0.04 0.05 0.03 0.04 6.1e-05 8.5e-06 1.6e-04 1.3e-05
4 PL alternative TSS XM_006240912.4 0.04 0.03 4.5e-06 0.04 0.05 0.04 0.04 5.2e-05 8.0e-06 4.3e-05 1.3e-05
5 Eye alternative TSS XM_008765097.3 0.44 0.23 1.4e-03 0.11 0.11 0.1 0.12 8.2e-03 8.4e-03 1.5e-02 7.0e-03
6 Brain alternative TSS XM_006240912.4 0.07 0.05 1.1e-05 0.04 0.04 0.04 0.04 4.6e-05 2.1e-04 2.1e-04 1.3e-04
7 Adipose gene expression Midn 0.06 0.04 1.3e-06 0.06 0.05 0.05 0.05 9.8e-07 2.2e-06 2.1e-06 1.3e-06
8 Brain alternative TSS XM_006240912.4 0.07 0.05 1.1e-05 0.05 0.04 0.04 0.04 2.1e-05 2.1e-04 1.6e-04 8.3e-05
9 NAcc isoform ratio XM_006240912.4 0.03 0.02 6.6e-04 0.02 0.02 0.02 0.01 9.0e-04 4.1e-03 3.8e-03 6.1e-03
10 Brain isoform ratio XM_006240912.4 0.08 0.06 3.1e-06 0.05 0.05 0.05 0.04 1.1e-05 2.3e-05 2.7e-05 5.5e-05
11 Eye gene expression Midn 0.32 0.18 2.2e-03 0.12 0.11 0.09 0.11 6.4e-03 9.1e-03 1.5e-02 8.2e-03
12 LHb isoform ratio XM_006240912.4 0.16 0.11 1.3e-03 0.06 0.03 0.03 0.03 1.8e-02 6.8e-02 7.0e-02 5.6e-02
13 PL isoform ratio XM_006240912.4 0.07 0.04 4.1e-09 0.08 0.08 0.08 0.09 1.4e-09 2.3e-09 3.2e-09 1.3e-09
14 NAcc alternative TSS XM_006240912.4 0.02 0.02 4.8e-03 0.02 0.01 0.01 0.01 5.3e-03 1.4e-02 2.3e-02 2.1e-02
15 NAcc alternative TSS XM_006240912.4 0.02 0.02 6.2e-03 0.02 0.01 0.01 0.01 4.2e-03 9.7e-03 1.6e-02 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.30.51.1-0.3-1.10.40.4-0.2-1.00.7-1.0-0.7-0.70.7-0.60.6-0.6-0.6
Area under the delay curve2.42.52.81.61.21.71.7-1.6-1.61.6-1.6-1.5-1.61.6-1.71.6-1.5-1.5
BMI with tail6.621.524.04.94.84.74.7-4.7-4.54.5-4.5-4.7-4.64.5-4.54.6-4.6-4.6
BMI without tail2.14.37.22.62.72.32.2-2.2-1.81.8-1.8-1.9-1.71.9-1.91.9-2.1-2.1
Body weight1.24.95.92.42.32.32.3-2.2-2.12.1-2.1-2.3-2.12.1-2.12.2-2.3-2.3
Weight adjusted by age0.30.31.01.00.90.60.6-0.5-0.40.3-0.4-0.4-0.50.3-0.30.3-0.5-0.5
Bone surface0.30.54.4-1.2-2.1-0.2-0.10.3-0.50.4-0.5-0.4-0.30.4-0.30.3-0.2-0.2
Bone volume0.30.54.5-1.0-2.1-0.1-0.00.3-0.60.4-0.7-0.5-0.40.4-0.30.3-0.3-0.3
Breakpoint value in progressive ratio session5.96.57.1-2.4-2.1-2.6-2.62.52.6-2.62.62.62.6-2.62.7-2.62.52.5
Number of licking bursts0.10.10.40.50.60.10.1-0.10.1-0.10.10.0-0.0-0.10.2-0.20.20.2
Context. condit. distance diff. score0.20.20.40.50.60.50.5-0.6-0.00.5-0.00.0-0.00.6-0.60.6-0.6-0.6
Locomotion velocity, session 10.30.41.3-1.0-1.2-0.7-0.60.70.3-0.60.30.30.4-0.50.4-0.50.50.5
Locomotion distance, session 10.10.21.0-1.0-0.9-0.3-0.20.10.30.20.30.20.30.2-0.20.2-0.1-0.1
Locomotion velocity, session 23.54.07.5-2.7-2.5-2.1-2.12.02.1-1.82.12.02.0-1.61.5-1.71.71.7
Locomotion distance, session 21.01.54.2-2.0-2.0-1.3-1.31.30.8-1.00.80.90.8-1.00.9-1.01.01.0
Locomotion velocity, session 37.08.29.9-2.8-2.5-2.9-2.92.83.1-2.83.13.12.9-2.82.7-2.82.92.9
Locomotion distance, session 30.00.00.10.10.1-0.0-0.0-0.10.30.00.30.20.10.00.0-0.0-0.0-0.0
Stereotopy head waving bouts, day 35.26.27.8-2.8-2.5-2.6-2.62.42.7-2.32.72.72.4-2.32.2-2.32.32.3
Stereotopy head waving duration, day 36.37.68.7-2.9-2.6-2.8-2.82.72.9-2.62.92.92.7-2.62.5-2.62.72.7
Locomotion velocity, session 70.90.91.8-0.7-1.1-0.7-0.71.01.4-0.91.41.31.0-0.80.8-0.80.70.7
Locomotion distance, session 70.10.10.50.70.60.40.4-0.20.00.00.00.1-0.10.1-0.10.1-0.2-0.2
Stereotopy head waving bouts, day 70.00.10.3-0.4-0.5-0.1-0.1-0.00.10.30.10.00.00.2-0.30.2-0.1-0.1
Stereotopy head waving duration, day 70.10.21.0-0.8-1.0-0.4-0.40.40.3-0.10.30.20.2-0.10.1-0.10.20.2
Locomotion velocity, session 80.50.62.0-1.3-1.4-0.7-0.70.71.0-0.41.01.00.5-0.40.3-0.40.40.4
Locomotion distance, session 80.10.20.6-0.8-0.5-0.5-0.50.30.6-0.30.60.70.6-0.20.2-0.20.20.2
Degree of sensitization distance0.30.30.50.70.50.70.7-0.6-0.50.6-0.5-0.5-0.50.6-0.60.6-0.7-0.7
Degree of sensitization stereotypy2.12.33.01.20.91.51.5-1.5-1.61.7-1.6-1.7-1.51.7-1.61.6-1.6-1.6
Conditioned locomotion1.11.33.31.61.81.31.2-1.2-1.00.9-1.0-1.0-1.10.9-1.01.0-0.9-0.9
Cocaine response after cond. corrected4.65.18.93.02.92.42.4-2.4-2.31.9-2.2-1.9-2.02.0-2.12.0-2.0-2.0
Cocaine response after cond. not corrected4.85.39.23.03.02.52.4-2.4-2.22.0-2.2-1.9-2.02.1-2.12.1-2.1-2.1
Cocaine response before conditioning0.50.61.0-0.9-0.9-0.8-0.80.81.0-0.71.00.70.8-0.70.7-0.70.60.6
Saline control response0.00.10.20.30.40.20.2-0.2-0.20.1-0.2-0.3-0.30.2-0.10.1-0.2-0.2
Bone: connectivity density0.50.71.20.1-0.40.70.7-0.7-1.11.0-1.1-0.9-1.01.1-1.00.9-0.8-0.8
Bone: cortical apparent density0.91.21.91.11.01.11.1-1.1-1.41.0-1.4-1.2-1.31.0-1.01.0-1.0-1.0
Bone: cortical area0.71.01.40.80.11.11.1-0.8-1.01.1-1.0-1.2-1.11.1-1.11.1-1.1-1.1
Bone: cortical porosity0.40.41.2-0.9-1.1-0.7-0.60.80.5-0.50.50.50.5-0.60.6-0.60.60.6
Bone: cortical porosity0.10.10.6-0.4-0.7-0.0-0.00.1-0.10.2-0.1-0.1-0.20.1-0.10.2-0.1-0.1
Bone: cortical thickness1.32.12.61.30.91.51.5-1.3-1.51.5-1.6-1.6-1.61.4-1.51.5-1.5-1.5
Bone: cortical thickness0.00.00.20.40.40.0-0.00.10.1-0.30.10.00.2-0.30.3-0.30.20.2
Bone: cortical tissue density0.60.81.40.90.80.90.9-0.9-1.20.8-1.2-1.0-1.10.9-0.80.8-0.8-0.8
Condit. Reinf. active minus inactive responses4.75.26.1-2.4-2.1-2.4-2.42.22.5-2.22.52.32.5-2.22.1-2.22.32.3
Condit. Reinf. active-inactive response ratio2.42.63.1-1.4-1.2-1.7-1.71.61.5-1.61.51.51.8-1.71.6-1.71.71.7
Condit. Reinf. active responses3.64.56.6-2.6-2.3-2.3-2.22.12.2-1.92.22.02.2-1.91.9-1.92.02.0
Condit. Reinf. inactive responses0.60.82.1-1.5-1.4-0.9-0.90.90.8-0.70.80.70.7-0.60.6-0.70.70.7
Incentive salience index mean2.32.84.2-2.1-1.8-1.8-1.81.61.8-1.41.81.61.8-1.41.4-1.41.51.5
Condit. Reinf. lever presses0.10.10.6-0.7-0.8-0.00.0-0.0-0.20.4-0.2-0.4-0.20.3-0.40.4-0.3-0.3
Condit. Reinf. active minus inactive responses2.32.83.7-1.3-1.3-1.6-1.71.71.6-1.81.51.51.5-1.91.9-1.91.91.9
Condit. Reinf. active-inactive response ratio0.20.20.40.20.4-0.2-0.30.3-0.1-0.6-0.20.00.0-0.60.6-0.60.70.7
Condit. Reinf. active responses2.12.93.4-1.4-1.7-1.6-1.71.81.7-1.81.61.51.5-1.81.8-1.81.81.8
Condit. Reinf. inactive responses1.21.52.2-1.1-1.5-1.1-1.11.31.5-1.11.51.21.2-1.11.1-1.11.11.1
Condit. Reinf. lever presses2.43.34.1-1.5-1.4-1.8-1.81.91.7-2.01.71.61.8-2.02.0-2.01.91.9
Condit. Reinf. lever reinforcers received1.62.22.8-1.1-1.3-1.4-1.41.61.5-1.61.51.31.3-1.61.7-1.71.71.7
Conditioned reinforcement - actives2.12.12.6-1.5-1.5-1.5-1.51.51.4-1.41.41.41.4-1.41.6-1.41.31.3
Conditioned reinforcement - inactives0.40.41.10.81.00.70.6-0.7-0.50.6-0.5-0.5-0.50.6-0.60.7-0.7-0.7
Conditioned locomotion7.18.58.9-3.0-2.8-3.0-3.02.92.9-2.92.92.92.9-2.93.0-2.92.92.9
Patch foraging indifference point 0 sec0.20.30.50.40.20.50.5-0.4-0.50.5-0.5-0.7-0.70.5-0.50.5-0.5-0.5
Patch foraging indifference point AUC0.80.91.2-0.9-0.7-1.0-1.01.00.8-1.00.80.81.0-1.01.1-1.00.90.9
Delay disc. indifference point, 0s delay8.18.910.22.31.92.93.0-2.9-3.23.2-3.2-3.2-3.23.2-3.13.1-3.0-3.0
Delay disc. indifference point, 16s delay0.10.10.20.30.20.30.3-0.3-0.40.4-0.4-0.3-0.40.4-0.50.4-0.4-0.4
Delay disc. indifference point, 2s delay6.26.87.72.42.12.72.7-2.7-2.62.8-2.6-2.6-2.62.8-2.72.7-2.6-2.6
Delay disc. indifference point, 24s delay0.80.81.11.10.70.90.9-0.7-1.00.7-1.0-1.0-0.90.7-0.80.8-1.0-1.0
Delay disc. indifference point, 4s delay1.11.11.70.90.51.01.1-1.1-1.01.2-1.0-1.0-1.01.2-1.31.2-1.0-1.0
Delay disc. indifference point, 8s delay1.11.12.01.41.21.21.2-1.1-1.01.0-1.0-0.9-1.01.0-1.01.0-0.9-0.9
Indifference point function ln k0.20.30.50.70.40.60.6-0.6-0.50.5-0.5-0.5-0.50.6-0.60.6-0.4-0.4
Indifference point function log k0.20.30.50.70.40.60.6-0.6-0.50.5-0.5-0.5-0.50.6-0.60.6-0.4-0.4
Patch foraging total patch changes 0 sec0.10.20.30.40.20.40.4-0.3-0.30.4-0.4-0.5-0.60.4-0.30.4-0.4-0.4
Patch foraging total patch changes 12 sec0.30.31.30.81.10.60.6-0.6-0.50.4-0.5-0.5-0.40.4-0.40.4-0.6-0.6
Patch foraging total patch changes 18 sec1.11.41.7-1.2-1.1-1.2-1.21.21.2-1.21.11.11.2-1.21.3-1.31.11.1
Patch foraging total patch changes 24 sec0.00.10.1-0.3-0.3-0.3-0.20.30.0-0.3-0.0-0.00.1-0.30.4-0.30.20.2
Patch foraging total patch changes 6 sec0.20.30.4-0.6-0.7-0.5-0.50.60.4-0.60.40.40.2-0.60.6-0.60.50.5
Patch foraging time to switch 0 sec1.32.03.00.70.81.31.3-1.4-1.31.6-1.3-1.2-1.21.6-1.71.7-1.7-1.7
Patch foraging water rate 0 sec0.10.10.40.60.6-0.0-0.00.00.5-0.30.50.40.2-0.30.4-0.40.40.4
Patch foraging water rate 12 sec0.81.33.31.81.81.21.2-1.1-1.00.7-1.0-1.1-1.00.8-0.80.8-0.9-0.9
Patch foraging water rate 18 sec0.40.50.90.61.0-0.3-0.30.30.7-0.90.70.60.7-0.80.8-0.90.90.9
Patch foraging water rate 24 sec0.30.43.01.41.70.50.5-0.6-0.10.0-0.1-0.1-0.20.10.0-0.00.00.0
Patch foraging water rate 6 sec0.40.61.10.10.2-0.6-0.60.70.7-1.10.70.70.8-1.01.0-1.00.90.9
Seeking ratio, delayed vs. immediate footshock4.24.86.2-2.4-2.5-2.3-2.22.32.1-2.12.12.12.1-2.12.1-2.12.12.1
Distance traveled before self-admin0.70.70.90.60.40.80.8-0.8-0.90.9-0.9-0.9-0.90.9-0.80.9-0.9-0.9
Distance traveled after self-admin0.50.50.9-0.9-0.9-0.7-0.70.80.6-0.80.60.60.7-0.70.8-0.70.60.6
Extensor digitorum longus weight4.417.222.44.74.74.44.3-4.4-3.64.2-3.6-3.9-3.84.1-4.14.1-4.1-4.1
Bone: elastic displacement0.20.20.4-0.4-0.7-0.4-0.40.50.0-0.50.00.20.4-0.50.5-0.50.40.4
Bone: elastic work0.30.40.80.60.00.60.6-0.5-0.90.5-0.8-0.6-0.50.6-0.60.6-0.6-0.6
Bone: endosteal estimation0.20.40.60.50.30.60.6-0.7-0.40.7-0.3-0.6-0.40.8-0.80.8-0.7-0.7
Bone: endosteal perimeter0.20.41.4-0.9-1.2-0.6-0.60.70.7-0.50.70.60.7-0.40.4-0.50.60.6
Epididymis fat weight0.30.70.9-0.8-0.1-0.9-0.90.60.9-0.80.90.90.9-0.80.7-0.80.90.9
Delta time in closed arm before/after self-admin0.60.62.81.41.70.80.7-0.8-0.50.4-0.5-0.5-0.40.4-0.30.4-0.4-0.4
Delta time in open arm before/after self-admin1.21.21.50.90.91.11.1-1.0-1.21.1-1.2-1.2-1.11.1-1.21.1-1.1-1.1
Diff in mean of infusions in LGA sessions2.12.42.6-1.6-1.4-1.6-1.61.51.6-1.51.61.61.6-1.41.5-1.51.51.5
Delay discount exponential model param2.22.32.6-1.6-1.2-1.6-1.61.51.5-1.51.51.51.5-1.51.6-1.51.51.5
Extinction: sum of active levers before priming1.41.41.7-0.9-0.5-1.1-1.21.01.3-1.21.31.31.3-1.21.3-1.21.11.1
Active lever presses in extinction session 62.42.43.0-1.7-1.7-1.6-1.61.71.4-1.61.41.41.5-1.61.7-1.61.41.4
Bone: final force1.42.22.71.40.81.61.6-1.4-1.41.6-1.3-1.6-1.51.6-1.61.6-1.5-1.5
Bone: final moment1.11.72.11.20.61.41.4-1.2-1.31.4-1.2-1.4-1.31.4-1.41.4-1.4-1.4
Food consumed during 24 hour testing period0.50.61.01.00.80.90.9-0.9-0.80.9-0.7-0.6-0.70.9-0.70.8-0.7-0.7
Glucose1.62.43.31.71.51.61.6-1.5-1.61.4-1.6-1.6-1.81.5-1.41.4-1.4-1.4
Heart weight0.30.40.8-0.4-0.2-0.6-0.70.70.3-0.90.30.30.5-0.90.8-0.80.90.9
Delay discount hyperbolic model param3.03.23.6-1.9-1.4-1.9-1.91.81.8-1.91.81.71.8-1.81.9-1.81.81.8
Intermittent access intake day 1-15 change6.96.87.6-2.5-2.4-2.6-2.62.72.6-2.72.62.62.6-2.72.8-2.72.52.5
Intermittent access intake escalation6.86.78.1-2.2-1.9-2.6-2.62.62.7-2.72.72.72.7-2.72.8-2.72.62.6
Intermittent access intake escalation 28.58.49.9-2.5-2.1-2.9-2.92.92.9-3.12.92.92.9-3.13.1-3.12.92.9
Intermitt. access day 1 inactive lever presses0.20.20.4-0.1-0.0-0.3-0.30.40.5-0.50.50.50.5-0.50.6-0.50.40.4
Intermitt. access day 15 inactive lever presses0.60.60.8-0.7-0.5-0.8-0.80.80.8-0.90.80.80.8-0.90.8-0.80.80.8
Intermitt. access escalation Index0.40.40.60.2-0.30.50.5-0.5-0.60.8-0.6-0.6-0.60.8-0.50.6-0.8-0.8
Intermittent access day 1 total infusions0.00.00.10.20.10.20.2-0.2-0.20.2-0.2-0.2-0.20.2-0.30.3-0.1-0.1
Intermittent access day 15 total infusions2.22.42.7-1.4-1.2-1.5-1.51.61.6-1.71.61.61.6-1.71.6-1.61.61.6
Intermittent access terminal intake (last 3 days)1.11.21.5-1.0-1.0-1.1-1.11.21.1-1.21.11.11.1-1.21.2-1.11.01.0
Intermittent access total infusions0.20.20.3-0.4-0.3-0.5-0.50.50.5-0.50.50.50.5-0.50.5-0.50.50.5
Intermittent access day 1 locomotion0.40.50.6-0.6-0.5-0.7-0.70.60.8-0.70.80.80.8-0.70.6-0.60.70.7
Intermittent access day 15 total locomotion3.74.04.3-2.0-1.6-2.1-2.12.02.1-2.02.12.12.1-2.02.0-1.91.91.9
Intermittent access total locomotion0.91.01.2-1.1-1.0-1.1-1.11.01.0-1.01.01.01.0-1.01.0-0.90.90.9
Intermittent access standard deviation2.93.13.7-1.5-1.3-1.7-1.71.81.8-1.91.81.81.8-1.91.8-1.81.71.7
Left kidney weight0.00.00.3-0.3-0.6-0.1-0.10.20.1-0.10.1-0.00.2-0.10.0-0.0-0.0-0.0
Right kidney weight1.43.94.8-2.0-2.1-2.0-2.02.12.0-2.02.01.92.2-2.02.0-1.91.91.9
Cocaine induced anxiety0.40.41.4-1.0-1.2-0.7-0.60.80.4-0.70.40.40.4-0.70.6-0.50.40.4
Post-drug Anxiety0.40.41.1-1.0-1.0-0.7-0.60.80.5-0.70.50.50.5-0.70.3-0.40.50.5
Baseline Anxiety0.30.30.4-0.20.1-0.5-0.50.40.6-0.60.60.60.6-0.60.3-0.50.60.6
Tail length3.410.312.0-3.0-2.7-3.2-3.23.23.4-3.33.43.43.5-3.23.2-3.23.13.1
Length with tail1.96.88.3-2.7-2.9-2.6-2.62.82.5-2.62.52.62.7-2.52.6-2.52.42.4
Length without tail0.00.10.8-0.6-0.9-0.2-0.20.30.10.00.1-0.10.00.00.00.00.10.1
Times rat made contact with spout0.10.20.60.70.80.40.4-0.4-0.20.3-0.2-0.1-0.40.3-0.30.3-0.3-0.3
Lifetime Intake0.10.10.1-0.3-0.2-0.3-0.30.30.3-0.30.30.30.3-0.30.3-0.20.30.3
Liver weight, left2.23.55.62.02.41.91.9-2.0-1.71.8-1.7-1.8-1.71.8-1.91.9-1.8-1.8
Liver weight, right1.72.83.21.51.81.71.7-1.8-1.41.8-1.4-1.5-1.41.7-1.81.8-1.8-1.8
Locomotor activity2.84.48.5-2.5-2.9-2.1-2.12.41.9-2.01.91.81.8-2.02.1-2.01.91.9
Locomotor testing distance1.72.84.9-1.9-2.2-1.7-1.71.91.4-1.71.51.41.5-1.71.7-1.71.61.6
Locomotor testing rearing0.00.10.20.10.0-0.1-0.10.30.2-0.40.2-0.00.2-0.40.4-0.40.30.3
Locomotion in novel chamber0.20.20.5-0.2-0.1-0.4-0.50.50.4-0.70.40.40.4-0.60.7-0.60.50.5
Locomotion in novel chamber post-restriction1.01.21.8-0.9-0.9-1.1-1.11.01.4-1.01.41.31.2-1.01.0-1.11.11.1
Fecal boli incidents, locomotor time 11.71.93.11.51.81.41.4-1.4-1.21.2-1.2-1.1-1.21.2-1.11.3-1.7-1.7
Change in fecal boli incidents, locomotor task0.10.10.9-0.3-1.0-0.2-0.20.50.2-0.30.20.20.1-0.30.4-0.30.10.1
Time >=10cm from walls, locomotor time 10.80.81.40.60.10.91.0-0.5-1.10.7-1.1-1.1-1.20.7-0.70.9-1.2-1.2
Bouts of movement, locomotor time 10.20.30.5-0.4-0.3-0.4-0.40.40.7-0.50.70.70.6-0.50.5-0.40.50.5
Total resting periods, locomotor time 10.30.30.6-0.5-0.5-0.5-0.50.50.8-0.50.80.80.7-0.50.5-0.50.50.5
Rest time, locomotor task time 10.30.40.8-0.7-0.5-0.6-0.60.40.9-0.30.90.90.8-0.30.4-0.30.40.4
Distance moved, locomotor task time 10.90.91.60.60.10.90.9-0.6-1.30.8-1.3-1.2-1.20.8-0.90.9-1.1-1.1
Vertical activity count, locomotor time 10.20.20.60.80.30.50.5-0.2-0.70.2-0.7-0.6-0.70.2-0.10.2-0.3-0.3
Time >=10cm from walls, locomotor time 21.41.52.41.51.31.41.4-1.1-1.31.0-1.3-1.2-1.31.0-1.01.1-1.2-1.2
Bouts of movement, locomotor time 20.40.41.1-1.0-1.0-0.7-0.70.50.5-0.30.50.50.6-0.30.3-0.40.70.7
Total resting periods, locomotor time 20.30.31.0-1.0-1.0-0.7-0.60.50.5-0.30.50.40.5-0.30.2-0.40.70.7
Rest time, locomotor task time 20.50.61.3-1.0-1.1-0.8-0.80.90.7-0.70.70.70.8-0.70.6-0.60.70.7
Distance moved, locomotor task time 20.70.81.51.01.20.90.9-1.0-0.80.8-0.8-0.8-0.80.8-0.80.8-0.8-0.8
Vertical activity count, locomotor time 20.60.61.91.21.40.90.8-0.9-0.60.7-0.6-0.5-0.60.7-0.50.6-0.7-0.7
Light reinforcement 15.810.613.7-3.7-3.4-3.5-3.43.43.0-3.23.03.03.2-3.23.2-3.23.23.2
Light reinforcement 21.92.63.7-1.9-1.8-1.7-1.71.71.4-1.51.41.51.4-1.61.6-1.61.61.6
Bone: marrow area0.20.40.70.50.30.60.6-0.7-0.40.8-0.3-0.6-0.40.8-0.80.8-0.7-0.7
Bone: maximum diameter0.61.03.0-1.3-1.7-1.0-1.01.11.0-0.81.00.80.9-0.80.8-0.80.80.8
Bone: maximum force1.32.22.61.50.91.61.6-1.4-1.31.5-1.3-1.6-1.41.5-1.61.6-1.5-1.5
Bone: maximum moment1.01.82.11.30.81.41.4-1.2-1.31.4-1.2-1.4-1.31.4-1.51.4-1.4-1.4
Mean time between licks in bursts4.46.16.9-2.3-2.1-2.5-2.52.62.5-2.62.52.32.2-2.62.6-2.62.62.6
Mean num. licks in bursts0.00.10.10.0-0.00.20.2-0.2-0.20.3-0.2-0.0-0.10.3-0.30.3-0.4-0.4
Cd content in liver0.30.40.90.60.30.60.6-0.4-0.70.5-0.7-0.9-0.90.5-0.50.5-0.5-0.5
Co content in liver0.60.71.0-0.7-0.7-0.8-0.80.81.0-0.91.00.80.9-0.80.9-0.90.90.9
Cu content in liver0.20.20.30.1-0.20.40.5-0.3-0.40.5-0.4-0.5-0.50.6-0.60.6-0.6-0.6
Fe content in liver0.10.20.6-0.10.2-0.3-0.30.10.8-0.30.80.70.5-0.20.3-0.30.30.3
K content in liver0.10.10.1-0.3-0.40.10.2-0.20.20.30.2-0.2-0.30.4-0.30.3-0.3-0.3
Mg content in liver0.10.10.2-0.2-0.40.20.2-0.2-0.00.3-0.0-0.4-0.40.4-0.40.4-0.4-0.4
Mn content in liver0.70.83.6-1.5-1.9-0.8-0.80.81.0-0.51.00.90.7-0.40.4-0.40.50.5
Na content in liver1.11.11.90.60.61.01.1-1.2-0.71.2-0.7-1.0-1.01.4-1.31.3-1.2-1.2
Rb content in liver0.60.71.10.30.10.70.8-0.7-0.81.0-0.8-0.9-1.01.0-0.91.0-0.9-0.9
Se content in liver0.30.40.9-0.7-0.5-0.5-0.50.30.9-0.20.90.90.9-0.20.4-0.40.40.4
Sr content in liver0.10.10.10.20.3-0.1-0.10.10.3-0.20.30.30.3-0.20.3-0.30.30.3
Zn content in liver2.12.33.2-0.9-0.5-1.5-1.51.31.5-1.61.51.51.7-1.71.8-1.71.81.8
Bone: minimum diameter0.00.00.2-0.0-0.40.10.1-0.10.20.30.2-0.1-0.00.3-0.30.3-0.2-0.2
Time in familiar zone, hab. session 12.82.63.7-1.4-1.2-1.6-1.61.61.5-1.81.51.91.8-1.71.6-1.71.71.7
Time in novel zone, hab. session 11.51.52.30.90.41.21.2-1.1-1.21.4-1.2-1.5-1.41.3-1.21.3-1.3-1.3
Total zone transitions, hab. session 10.71.02.5-1.6-1.6-1.1-1.01.01.0-0.81.00.80.7-0.80.7-0.80.80.8
Total locomotion distance, hab. session 10.91.24.0-1.8-2.0-1.1-1.11.11.2-0.81.21.00.9-0.70.6-0.70.70.7
Locomotion velocity, hab. session 11.31.94.2-2.1-2.0-1.4-1.41.41.5-1.11.51.31.2-1.11.0-1.01.01.0
Time in familiar zone, hab. session 27.17.38.6-2.4-2.0-2.8-2.82.72.6-2.92.62.82.9-2.82.8-2.82.82.8
Time in novel zone, hab. session 25.45.46.22.11.62.42.4-2.3-2.32.5-2.3-2.5-2.52.4-2.42.4-2.4-2.4
Total zone transitions, hab. session 20.30.40.8-0.4-0.30.40.4-0.5-0.60.7-0.6-0.9-0.80.8-0.80.8-0.7-0.7
Total locomotion distance, hab. session 20.81.02.9-1.7-1.4-1.1-1.11.00.9-0.80.90.70.9-0.80.7-0.80.80.8
Locomotion velocity, hab. session 20.70.93.1-1.8-1.5-1.1-1.01.00.8-0.70.80.60.8-0.70.6-0.70.70.7
Novel to familiar place preference ratio5.15.26.21.91.42.32.3-2.2-2.42.4-2.4-2.4-2.52.4-2.32.4-2.4-2.4
Novelty place preference3.23.23.91.41.01.81.8-1.7-1.92.0-1.9-1.9-1.91.9-1.91.9-1.9-1.9
Time in novel zone, NPP test3.53.64.21.51.11.91.9-1.8-1.92.0-1.9-1.9-2.02.0-2.02.0-2.0-2.0
Total zone transitions, NPP test0.10.10.3-0.5-0.3-0.00.0-0.1-0.30.2-0.3-0.3-0.40.2-0.30.2-0.2-0.2
Total locomotion distance, NPP test0.10.10.2-0.4-0.30.10.1-0.2-0.20.3-0.2-0.3-0.40.4-0.50.4-0.4-0.4
Locomotion velocity, NPP test0.10.10.5-0.7-0.6-0.2-0.10.10.00.00.0-0.1-0.10.1-0.20.1-0.1-0.1
Intraocular pressure0.10.20.50.40.7-0.2-0.20.2-0.0-0.5-0.00.40.3-0.50.5-0.50.50.5
Delta distance traveled before/after self-admin1.92.12.3-1.5-1.4-1.4-1.41.51.5-1.51.51.51.4-1.51.4-1.41.31.3
Delta ambulatory time before/after self-admin2.02.22.5-1.6-1.5-1.5-1.51.51.5-1.51.51.51.5-1.41.4-1.41.41.4
Parametrial fat weight0.40.81.3-0.7-0.7-0.9-0.90.90.9-1.00.91.11.1-1.01.0-1.00.80.8
Pavlov. Cond. lever latency0.10.10.20.40.4-0.0-0.10.1-0.3-0.4-0.3-0.1-0.1-0.30.4-0.40.30.3
Pavlov. Cond. magazine entry latency3.74.76.4-2.2-1.7-2.2-2.22.02.5-2.02.52.42.4-2.02.0-2.02.12.1
Pavlov. Cond. change in total contacts0.20.20.6-0.5-0.3-0.3-0.30.20.8-0.10.80.60.6-0.20.2-0.20.20.2
Pavlov. Cond. index score0.60.81.6-1.1-0.9-0.8-0.80.71.3-0.51.31.11.1-0.60.5-0.50.60.6
Pavlov. Cond. latency score0.50.71.4-1.2-1.1-0.8-0.80.71.2-0.41.21.01.0-0.50.4-0.40.50.5
Pavlov. Cond. lever contacts0.10.10.5-0.6-0.7-0.2-0.10.10.50.30.50.30.20.1-0.20.2-0.1-0.1
Pavlov. Cond. magazine entry number1.01.22.11.20.81.11.1-1.0-1.40.9-1.4-1.3-1.31.0-0.90.9-1.0-1.0
Pavlov. Cond. intertrial magazine entries0.20.20.4-0.10.1-0.4-0.40.40.3-0.60.30.30.4-0.50.6-0.60.60.6
Pavlov. Cond. lever-magazine prob. diff.1.01.32.2-1.4-1.1-1.1-1.11.01.5-0.81.51.31.4-0.90.8-0.80.90.9
Pavlov. Cond. response bias1.51.82.9-1.4-1.1-1.4-1.31.21.7-1.11.71.51.5-1.21.1-1.11.21.2
Pavlov. Cond. lever latency0.70.91.40.71.20.90.9-1.2-0.81.1-0.8-0.8-0.81.1-1.11.0-1.0-1.0
Pavlov. Cond. magazine entry latency0.50.50.7-0.7-0.8-0.7-0.70.80.9-0.70.80.80.8-0.70.7-0.70.60.6
Pavlov. Cond. change in total contacts0.60.91.3-0.7-1.0-0.9-0.91.10.7-1.10.70.70.7-1.11.1-1.11.11.1
Pavlov. Cond. index score0.81.11.5-0.8-1.1-0.9-1.01.21.0-1.21.01.00.9-1.21.1-1.11.01.0
Pavlov. Cond. latency score0.70.91.4-0.8-1.2-0.9-0.91.20.8-1.10.80.80.8-1.11.0-1.00.90.9
Pavlov. Cond. lever contacts0.71.01.4-0.7-0.9-0.9-0.91.20.9-1.10.90.90.9-1.21.1-1.11.01.0
Pavlov. Cond. magazine entry number0.80.91.20.91.10.90.9-1.0-1.10.9-1.1-1.0-1.00.9-0.90.9-0.9-0.9
Pavlov. Cond. intertrial magazine entries0.20.30.80.80.90.60.6-0.6-0.40.4-0.4-0.6-0.50.4-0.40.4-0.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.81.11.5-0.8-1.2-0.9-1.01.21.0-1.11.01.00.9-1.11.1-1.11.01.0
Pavlov. Cond. response bias1.82.43.0-1.2-1.4-1.5-1.51.71.5-1.71.51.51.5-1.71.7-1.71.61.6
Time in closed arm before self-admin0.91.01.50.50.30.90.9-1.0-1.01.2-1.0-1.0-1.11.2-1.11.2-1.1-1.1
Time in closed arm after self-admin0.00.00.0-0.1-0.0-0.1-0.10.10.2-0.10.20.20.2-0.10.2-0.20.20.2
Time in open arm before self-admin0.70.81.1-0.7-0.8-0.9-0.90.90.8-0.90.80.80.9-0.91.0-0.90.90.9
Time in open arm after self-admin0.80.91.01.00.91.01.0-1.0-1.00.9-1.0-1.0-0.90.9-0.90.9-0.8-0.8
Bone: periosteal estimation0.40.81.10.60.00.90.9-0.8-0.71.1-0.7-1.0-0.81.0-1.11.1-1.0-1.0
Bone: periosteal perimeter0.10.10.9-0.4-1.0-0.1-0.10.30.20.00.10.00.1-0.0-0.00.00.10.1
Bone: post-yield work0.40.60.91.00.90.90.9-0.8-0.30.8-0.3-0.6-0.60.8-0.80.8-0.7-0.7
Progressive ratio test 1 active lever presses0.00.00.20.30.50.20.2-0.3-0.00.2-0.0-0.0-0.00.2-0.20.2-0.1-0.1
Progressive ratio test 1 breakpoint0.10.10.30.40.60.30.3-0.4-0.10.3-0.1-0.1-0.10.3-0.30.3-0.2-0.2
Progressive ratio test 1 inactive lever presses0.00.00.0-0.2-0.1-0.2-0.20.10.2-0.00.20.20.2-0.00.1-0.00.10.1
Progressive ratio test 2 active lever presses0.20.20.3-0.2-0.0-0.4-0.40.40.5-0.50.50.50.5-0.50.5-0.40.40.4
Progressive ratio test 2 breakpoint0.20.20.3-0.4-0.3-0.5-0.50.50.5-0.50.50.50.5-0.50.5-0.40.40.4
Progressive ratio test 2 inactive lever presses0.00.00.1-0.3-0.2-0.2-0.20.20.1-0.20.10.10.1-0.20.1-0.10.00.0
Incentive Sensitization - Responses0.10.10.3-0.10.0-0.3-0.30.30.4-0.40.40.40.4-0.40.5-0.40.20.2
Incentive Sensitization - Breakpoint0.20.20.3-0.2-0.1-0.4-0.40.40.5-0.50.50.50.5-0.50.6-0.40.30.3
Sum of active levers in priming session hrs 5-60.00.00.0-0.00.00.00.0-0.0-0.10.0-0.1-0.1-0.00.00.00.1-0.1-0.1
Progressive ratio0.10.10.90.41.00.30.3-0.5-0.10.3-0.1-0.1-0.10.3-0.40.4-0.3-0.3
Food seeking constrained by brief footshock0.20.30.7-0.8-0.2-0.6-0.60.30.8-0.30.80.80.6-0.30.2-0.30.40.4
Seeking ratio, punishment vs. effort0.20.20.6-0.7-0.7-0.5-0.50.40.5-0.30.50.50.3-0.20.4-0.30.30.3
Retroperitoneal fat weight0.20.71.50.91.20.80.8-1.0-0.60.9-0.7-0.7-0.50.9-1.00.9-0.8-0.8
Reaction time number correct0.40.51.71.31.30.80.7-0.9-0.40.6-0.4-0.4-0.50.6-0.50.5-0.4-0.4
Reaction time mean minus median0.70.91.3-0.7-0.8-0.9-0.91.00.9-1.00.90.90.9-1.00.9-1.01.11.1
Reaction time mean minus median AUC0.00.00.3-0.1-0.50.10.10.0-0.10.1-0.1-0.1-0.10.2-0.30.2-0.1-0.1
Reaction time num false alarms0.10.10.50.70.40.40.3-0.20.00.20.0-0.1-0.20.1-0.10.1-0.1-0.1
Reaction time num false alarms AUC0.10.10.80.90.70.40.4-0.30.00.20.0-0.1-0.20.2-0.10.2-0.1-0.1
Reaction time trials correct on left0.40.51.71.31.30.80.7-0.9-0.40.6-0.4-0.4-0.50.6-0.50.5-0.4-0.4
Reaction time trials on left0.40.51.71.31.30.80.8-0.9-0.40.7-0.4-0.4-0.50.7-0.60.6-0.4-0.4
Reaction time mean0.00.10.10.1-0.30.20.20.0-0.40.0-0.4-0.4-0.30.1-0.20.1-0.1-0.1
Reaction time mean AUC0.10.10.30.2-0.20.30.3-0.1-0.50.1-0.5-0.5-0.40.2-0.30.2-0.2-0.2
Median of all reaction times0.30.50.80.50.20.70.7-0.5-0.90.6-0.9-0.9-0.80.7-0.70.7-0.7-0.7
Reaction time omissions0.20.20.5-0.6-0.7-0.5-0.50.50.1-0.40.10.20.3-0.40.5-0.40.50.5
Reaction time false alarm rate0.00.00.10.30.00.20.2-0.1-0.00.1-0.0-0.1-0.10.1-0.10.1-0.1-0.1
Reaction time premature initiation rate1.21.62.2-1.0-0.8-1.3-1.31.31.1-1.41.11.11.2-1.51.4-1.41.41.4
Reaction time premature initiations0.81.11.7-0.4-0.2-0.9-1.01.01.0-1.21.01.01.0-1.21.2-1.21.31.3
Std. dev. reaction times0.20.20.4-0.3-0.6-0.4-0.40.50.4-0.50.30.30.4-0.50.4-0.50.60.6
Reaction time trials completed0.40.51.71.31.30.80.8-0.9-0.40.7-0.4-0.4-0.50.7-0.60.6-0.4-0.4
Reaction time trials AUC0.30.51.81.31.40.70.7-0.8-0.30.6-0.3-0.3-0.40.6-0.50.5-0.3-0.3
Run reversals in cocaine runway, females0.40.40.5-0.7-0.7-0.6-0.60.60.7-0.50.70.70.7-0.50.5-0.50.60.6
Run reversals in cocaine runway, males1.41.42.0-1.4-1.3-1.3-1.31.11.1-1.01.11.21.2-1.01.0-1.11.21.2
Latency to leave start box in cocaine runway0.50.52.3-1.0-1.5-0.7-0.60.90.2-0.70.20.10.1-0.70.6-0.60.50.5
Latency to leave start box in cocaine runway, F0.40.51.1-0.1-0.70.40.5-0.1-1.00.4-1.0-1.0-1.00.5-0.50.5-0.7-0.7
Latency to leave start box in cocaine runway, M3.33.23.8-1.4-1.2-1.7-1.71.82.0-1.92.01.91.8-1.91.9-1.91.91.9
Std. dev. time between licks in bursts0.60.82.0-0.9-1.4-0.8-0.81.00.9-0.90.90.60.6-0.80.8-0.80.80.8
Total sessions with >9 infusions0.10.10.10.1-0.20.20.2-0.1-0.30.3-0.3-0.3-0.30.3-0.10.3-0.3-0.3
Short access day 1 total inactive lever presses0.00.10.1-0.4-0.1-0.3-0.30.10.3-0.10.30.30.3-0.10.3-0.20.20.2
Short access day 10 total inactive lever presses0.00.00.10.10.20.00.00.1-0.0-0.2-0.0-0.0-0.0-0.20.3-0.20.20.2
Short access day 1 total infusions0.10.10.5-0.7-0.7-0.4-0.40.30.2-0.20.20.20.2-0.20.2-0.10.10.1
Short access day 10 total infusions0.10.10.1-0.10.1-0.2-0.20.10.4-0.10.40.40.4-0.10.1-0.10.30.3
Short access total infusions0.00.00.0-0.0-0.10.00.0-0.0-0.10.1-0.1-0.1-0.10.1-0.10.1-0.1-0.1
Short access day 1 locomotion0.80.91.8-1.2-1.4-1.0-1.01.00.9-0.90.90.90.9-0.90.9-0.80.80.8
Short access day 10 total locomotion3.94.35.3-1.9-1.9-2.1-2.12.02.1-2.02.12.12.1-2.02.3-2.12.12.1
Short access total locomotion0.70.81.2-0.9-1.1-0.9-0.90.90.8-0.80.80.80.8-0.81.0-0.80.80.8
One hour access (0.3 mA shock)0.10.20.30.40.50.40.4-0.5-0.30.4-0.3-0.3-0.30.4-0.50.5-0.3-0.3
Compulsive drug intake1.61.61.91.00.81.31.3-1.2-1.41.3-1.4-1.4-1.41.3-1.21.3-1.3-1.3
One hour access (shock baseline)0.20.20.4-0.10.0-0.4-0.40.30.6-0.40.60.60.6-0.40.3-0.40.50.5
Social response proportion0.60.61.2-1.1-1.0-0.9-0.80.90.6-0.80.60.60.5-0.80.7-0.70.80.8
Social responses6.58.311.1-3.2-3.3-2.9-2.93.12.7-2.92.82.62.7-2.82.8-2.82.82.8
Social time0.60.91.30.71.00.90.9-0.9-1.10.7-1.1-1.1-1.10.8-0.80.8-0.9-0.9
Soleus weight9.327.229.55.45.05.45.4-5.3-5.15.3-5.1-5.2-5.05.2-5.25.2-5.2-5.2
Bone: stiffness3.04.75.52.11.72.32.3-2.2-1.82.3-1.8-2.3-2.22.3-2.32.3-2.3-2.3
Tibialis anterior weight1.24.04.92.12.02.12.1-2.1-1.62.2-1.6-1.9-1.82.1-2.12.1-2.1-2.1
Time to tail flick, vehicle, before self-admin0.30.31.0-0.9-1.0-0.6-0.60.50.4-0.30.40.40.4-0.40.3-0.40.50.5
Time to tail flick, vehicle, after self-admin0.30.30.5-0.20.2-0.5-0.50.40.6-0.60.60.60.7-0.60.6-0.70.70.7
Time to tail flick, test, before self-admin0.20.10.9-0.6-1.0-0.3-0.30.40.1-0.20.10.10.2-0.20.3-0.20.20.2
Time to tail flick, test, after self-admin0.30.30.5-0.7-0.7-0.6-0.60.40.5-0.30.50.50.5-0.30.3-0.50.70.7
Delta time to tail flick, vehicle, before/after SA0.20.21.40.91.20.40.4-0.5-0.20.1-0.2-0.2-0.20.2-0.20.2-0.2-0.2
Delta time to tail flick, test, before/after SA0.30.30.5-0.20.1-0.5-0.50.30.7-0.50.70.70.6-0.50.4-0.50.60.6
Tibia length1.02.83.4-1.5-1.5-1.6-1.61.81.6-1.81.61.51.7-1.71.7-1.81.71.7
Ambulatory time before self-admin0.60.60.80.60.40.80.8-0.7-0.90.8-0.9-0.9-0.80.8-0.70.8-0.8-0.8
Ambulatory time after self-admin0.20.30.5-0.6-0.7-0.5-0.50.60.5-0.50.50.50.5-0.50.5-0.50.40.4
Bone: tissue strength1.91.92.41.31.11.41.4-1.3-1.51.3-1.4-1.6-1.51.3-1.41.4-1.4-1.4
Total heroin consumption2.02.32.6-1.6-1.5-1.6-1.61.51.5-1.41.51.51.5-1.51.5-1.51.51.5
Bone: trabecular number0.40.72.7-1.3-1.6-0.8-0.80.90.6-0.50.60.70.7-0.50.6-0.60.60.6
Bone: trabecular spacing0.30.43.01.31.70.60.5-0.6-0.10.0-0.1-0.2-0.20.1-0.10.1-0.1-0.1
Bone: trabecular thickness0.60.72.5-0.5-1.60.40.4-0.1-1.10.8-1.1-0.9-0.90.8-0.70.7-0.7-0.7
Bone: trabecular tissue density1.42.03.51.61.91.51.5-1.5-1.11.3-1.2-1.3-1.31.3-1.41.3-1.3-1.3
Water consumed over 24 hours0.70.81.10.80.31.01.0-0.8-0.91.0-0.8-0.9-1.01.0-1.01.0-1.0-1.0
Number of responses in last shaping day0.10.10.2-0.3-0.4-0.3-0.30.30.4-0.30.40.40.4-0.30.3-0.20.20.2