Micall1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Micall1	0.26	0.13	2.9e-03	0.03	0.01	-0	-0	8.0e-02	2.1e-01	4.5e-01	3.9e-01
2	NAcc	gene expression	Micall1	0.04	0.02	2.4e-05	0.01	0.03	0.03	0.03	3.2e-03	1.7e-05	1.8e-05	4.8e-05
3	Adipose	gene expression	Micall1	0.05	0.03	2.4e-04	0.03	0.02	0	0.03	4.1e-04	2.5e-03	7.7e-02	7.0e-04
4	Brain	gene expression	Micall1	0.09	0.04	1.5e-07	0.08	0.08	0.06	0.07	3.8e-08	7.8e-08	4.4e-06	2.1e-07
5	pVTA	gene expression	Micall1	0.14	0.07	1.1e-07	0.08	0.07	0.06	0.07	3.8e-07	3.8e-06	1.4e-05	5.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.0	0.0	0.1	0.2	-0.2	-0.2	0.2	0.3
Area under the delay curve	1.3	1.6	3.7	1.0	-1.9	1.2	-1.1	-0.8
BMI with tail	0.1	0.4	0.6	-0.5	0.4	-0.8	0.8	-0.3
BMI without tail	0.6	1.9	3.1	-0.2	1.6	-1.8	1.7	0.9
Body weight	0.8	3.3	6.4	-1.5	2.5	-1.8	1.8	1.2
Weight adjusted by age	0.2	0.3	1.1	-1.1	0.6	-0.2	0.1	-0.2
Bone surface	0.1	0.3	0.5	-0.2	-0.5	0.5	-0.5	-0.7
Bone volume	0.0	0.0	0.1	0.3	-0.1	-0.1	0.1	-0.0
Breakpoint value in progressive ratio session	0.1	0.1	0.4	0.3	-0.6	0.2	-0.2	-0.2
Number of licking bursts	0.3	0.5	1.5	1.2	0.1	-0.7	0.6	-0.1
Context. condit. distance diff. score	1.2	1.5	3.2	-1.5	1.8	-0.4	0.4	1.2
Locomotion velocity, session 1	0.9	0.9	3.0	-1.7	0.2	0.9	-0.7	-0.7
Locomotion distance, session 1	1.5	1.9	2.7	0.8	-1.6	1.5	-1.2	-1.6
Locomotion velocity, session 2	2.9	3.4	5.2	-1.3	-1.6	1.9	-2.0	-2.3
Locomotion distance, session 2	1.9	2.6	4.2	1.0	-2.0	1.7	-1.7	-1.4
Locomotion velocity, session 3	0.5	0.5	1.3	-1.0	1.1	0.3	-0.3	0.3
Locomotion distance, session 3	0.5	0.5	1.7	1.3	0.4	-0.5	0.6	0.3
Stereotopy head waving bouts, day 3	0.2	0.3	1.2	-1.1	0.3	0.1	-0.3	-0.1
Stereotopy head waving duration, day 3	1.3	1.5	6.6	-2.6	0.6	0.3	-0.5	-0.6
Locomotion velocity, session 7	0.7	0.7	1.1	-0.8	1.0	-0.9	1.0	0.2
Locomotion distance, session 7	1.1	1.3	2.2	-0.5	1.5	-1.2	1.1	1.3
Stereotopy head waving bouts, day 7	1.5	1.7	6.5	-2.6	0.3	0.7	-0.6	-1.0
Stereotopy head waving duration, day 7	1.6	1.9	5.9	-2.4	-0.2	1.1	-0.9	-1.3
Locomotion velocity, session 8	1.4	1.7	5.4	-2.3	0.3	1.2	-1.1	-0.8
Locomotion distance, session 8	0.4	0.5	1.1	-1.1	0.1	0.9	-0.9	0.1
Degree of sensitization distance	1.7	1.7	4.5	-2.1	1.3	-0.7	0.6	1.2
Degree of sensitization stereotypy	2.2	2.4	6.7	-2.6	-0.3	1.4	-1.2	-1.4
Conditioned locomotion	0.5	0.6	1.2	-1.1	0.9	-0.7	0.6	-0.1
Cocaine response after cond. corrected	0.7	0.8	1.4	-1.1	-0.6	0.8	-0.8	-1.2
Cocaine response after cond. not corrected	0.8	0.9	1.6	-0.7	-0.9	0.9	-0.9	-1.3
Cocaine response before conditioning	0.3	0.3	1.4	1.2	-0.4	-0.1	0.1	0.0
Saline control response	0.2	0.2	0.6	-0.2	0.7	0.1	0.2	0.7
Bone: connectivity density	0.2	0.2	0.4	-0.4	0.6	-0.5	0.4	0.5
Bone: cortical apparent density	1.9	2.6	4.1	1.3	1.4	-1.9	2.0	1.3
Bone: cortical area	0.3	0.4	1.6	-0.8	-0.2	-0.1	-0.1	-1.3
Bone: cortical porosity	1.0	1.0	1.8	-0.7	-0.9	1.1	-1.0	-1.3
Bone: cortical porosity	1.8	2.0	2.9	-1.6	-0.8	1.5	-1.3	-1.7
Bone: cortical thickness	0.4	0.6	2.0	1.4	-0.7	-0.3	0.0	-0.7
Bone: cortical thickness	0.7	0.8	1.9	1.4	-1.0	0.1	-0.3	-0.9
Bone: cortical tissue density	1.8	2.5	3.9	1.2	1.4	-1.9	2.0	1.3
Condit. Reinf. active minus inactive responses	1.0	1.1	1.6	0.8	1.1	-1.1	1.1	1.3
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.6	0.3	1.3	-0.9	0.8	1.1
Condit. Reinf. active responses	2.3	2.9	5.3	1.6	1.3	-1.5	1.6	2.3
Condit. Reinf. inactive responses	2.4	2.9	6.6	1.8	0.9	-1.4	1.5	2.6
Incentive salience index mean	2.0	2.5	3.5	1.1	1.5	-1.9	1.9	1.5
Condit. Reinf. lever presses	2.5	3.5	6.0	1.2	1.6	-2.4	2.4	1.4
Condit. Reinf. active minus inactive responses	0.4	0.5	1.1	0.0	-0.7	1.0	-1.1	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.6	-0.6	-0.3	0.7	-0.8	-0.0
Condit. Reinf. active responses	1.0	1.5	2.9	-0.4	-1.1	1.6	-1.7	-0.6
Condit. Reinf. inactive responses	0.6	0.7	1.2	0.1	-0.8	1.0	-1.0	-1.1
Condit. Reinf. lever presses	0.2	0.2	0.5	0.7	-0.3	0.2	-0.3	0.7
Condit. Reinf. lever reinforcers received	0.8	1.1	2.3	-0.6	-0.9	1.5	-1.5	-0.4
Conditioned reinforcement - actives	0.9	1.5	2.0	1.2	-1.4	1.2	-1.4	-0.8
Conditioned reinforcement - inactives	0.8	1.2	5.1	2.3	-0.9	-0.1	0.1	0.1
Conditioned locomotion	2.1	2.7	4.3	0.2	-1.9	2.1	-2.1	-1.1
Patch foraging indifference point 0 sec	0.8	1.5	2.7	0.0	1.6	-1.2	1.0	1.4
Patch foraging indifference point AUC	0.2	0.2	1.0	1.0	0.1	0.1	-0.2	0.1
Delay disc. indifference point, 0s delay	0.2	0.3	0.8	0.0	-0.9	0.5	-0.4	-0.3
Delay disc. indifference point, 16s delay	1.6	1.7	3.6	1.2	-1.9	1.1	-1.2	-1.0
Delay disc. indifference point, 2s delay	6.9	7.7	15.7	1.2	-4.0	2.8	-2.8	-2.4
Delay disc. indifference point, 24s delay	0.5	0.5	0.8	-0.0	0.8	-0.8	0.9	-0.6
Delay disc. indifference point, 4s delay	1.6	1.7	3.6	0.2	-1.9	1.5	-1.3	-0.9
Delay disc. indifference point, 8s delay	0.4	0.5	1.8	1.4	-0.4	-0.2	0.4	0.6
Indifference point function ln k	0.2	0.4	1.7	-1.3	0.5	-0.2	0.2	-0.1
Indifference point function log k	0.2	0.4	1.7	-1.3	0.5	-0.2	0.2	-0.1
Patch foraging total patch changes 0 sec	0.6	1.2	2.0	0.5	1.3	-1.0	0.9	1.4
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	-0.1	0.4	0.1	-0.5	-0.1
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	0.5	0.7	-0.6	0.3	0.3
Patch foraging total patch changes 24 sec	0.8	1.3	1.9	1.4	1.0	-1.0	0.8	1.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.7	0.5	-0.4	0.1	0.3
Patch foraging time to switch 0 sec	1.2	2.5	3.6	-1.0	-1.9	1.6	-1.6	-1.7
Patch foraging water rate 0 sec	2.4	5.1	8.0	0.3	2.8	-2.6	2.4	2.3
Patch foraging water rate 12 sec	0.9	1.9	3.5	0.7	1.2	-1.9	1.9	0.6
Patch foraging water rate 18 sec	2.0	3.2	5.4	-0.1	2.3	-2.2	2.1	1.0
Patch foraging water rate 24 sec	1.5	2.1	4.5	-1.2	2.1	-1.4	1.2	1.0
Patch foraging water rate 6 sec	2.9	4.2	6.2	1.3	2.1	-2.5	2.4	1.7
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	1.1	-0.1	-0.6	0.7	-1.0	-0.4
Distance traveled before self-admin	1.2	1.5	3.0	-0.3	-1.7	1.3	-1.4	-1.0
Distance traveled after self-admin	0.4	0.4	0.8	-0.5	0.9	-0.8	0.8	0.1
Extensor digitorum longus weight	0.5	2.1	5.3	1.5	-2.3	0.9	-0.9	-1.1
Bone: elastic displacement	0.3	0.4	1.7	-1.3	0.4	-0.0	0.1	-0.3
Bone: elastic work	1.5	2.0	7.0	-2.6	-0.1	0.8	-0.8	-1.3
Bone: endosteal estimation	0.8	1.7	6.4	-2.5	0.2	0.8	-0.7	-1.0
Bone: endosteal perimeter	1.0	2.2	6.7	-2.6	0.0	0.6	-0.5	-1.9
Epididymis fat weight	0.4	1.3	2.8	-1.7	1.6	-0.5	0.4	1.0
Delta time in closed arm before/after self-admin	0.5	0.4	0.8	0.9	-0.8	0.6	-0.5	-0.3
Delta time in open arm before/after self-admin	0.2	0.2	0.4	-0.6	-0.2	0.4	-0.5	-0.0
Diff in mean of infusions in LGA sessions	0.3	0.3	0.8	-0.2	0.9	-0.5	0.6	0.4
Delay discount exponential model param	1.3	1.4	3.4	-1.0	1.8	-1.1	0.9	0.8
Extinction: sum of active levers before priming	1.8	1.9	3.0	-0.3	-1.7	1.4	-1.4	-1.7
Active lever presses in extinction session 6	0.4	0.4	0.6	-0.7	-0.6	0.5	-0.5	-0.8
Bone: final force	0.6	1.0	2.6	-1.3	-0.5	0.5	-0.5	-1.6
Bone: final moment	0.6	0.9	2.2	-1.5	-0.3	0.4	-0.4	-1.5
Food consumed during 24 hour testing period	0.3	0.5	1.0	-0.2	-0.6	0.7	-0.7	-1.0
Glucose	0.9	1.4	2.3	0.9	0.9	-1.5	1.4	1.1
Heart weight	1.5	2.4	8.1	-2.8	1.6	-0.8	0.7	-0.4
Delay discount hyperbolic model param	1.9	2.1	4.9	-1.1	2.2	-1.4	1.2	0.9
Intermittent access intake day 1-15 change	0.1	0.1	0.5	0.7	-0.1	0.0	-0.1	0.2
Intermittent access intake escalation	0.1	0.1	0.6	0.8	0.1	-0.1	0.1	0.3
Intermittent access intake escalation 2	0.4	0.5	0.9	0.9	0.5	-0.6	0.6	0.8
Intermitt. access day 1 inactive lever presses	0.2	0.9	1.6	-0.6	1.3	-0.9	0.9	0.9
Intermitt. access day 15 inactive lever presses	0.2	0.3	0.4	0.4	0.6	-0.7	0.5	0.6
Intermitt. access escalation Index	0.3	0.5	1.9	1.4	-0.6	-0.1	0.3	-0.2
Intermittent access day 1 total infusions	1.8	2.9	4.2	0.2	-1.9	2.0	-1.9	-1.7
Intermittent access day 15 total infusions	1.0	1.4	2.2	0.8	-1.5	1.3	-1.2	-1.1
Intermittent access terminal intake (last 3 days)	1.1	1.4	1.9	0.4	-1.4	1.4	-1.3	-1.2
Intermittent access total infusions	2.6	3.1	4.6	0.5	-2.1	2.0	-1.9	-1.7
Intermittent access day 1 locomotion	0.5	0.6	1.1	0.7	-1.0	0.8	-0.7	-0.5
Intermittent access day 15 total locomotion	0.1	0.2	0.5	0.7	-0.5	0.4	-0.5	-0.1
Intermittent access total locomotion	0.1	0.2	0.6	0.8	-0.2	0.1	-0.1	0.3
Intermittent access standard deviation	0.1	0.2	0.3	-0.3	-0.4	0.5	-0.5	-0.3
Left kidney weight	2.0	9.3	37.0	-6.1	1.5	1.7	-1.7	-1.3
Right kidney weight	1.9	8.4	34.9	-5.9	2.6	0.6	-0.6	-0.1
Cocaine induced anxiety	0.1	0.2	0.4	-0.4	-0.2	0.5	-0.6	-0.1
Post-drug Anxiety	0.6	0.7	0.9	-0.4	0.8	-0.9	0.9	1.0
Baseline Anxiety	0.7	0.8	1.9	0.5	0.5	-1.2	1.4	0.5
Tail length	1.1	4.2	6.8	0.4	2.6	-2.0	2.0	2.4
Length with tail	0.9	4.0	9.0	-1.3	3.0	-1.6	1.7	1.9
Length without tail	0.7	2.2	7.5	-2.7	1.7	-0.2	0.4	0.3
Times rat made contact with spout	3.7	4.2	6.7	1.8	1.9	-2.5	2.6	1.2
Lifetime Intake	2.7	3.2	5.0	0.4	-2.2	2.0	-1.9	-1.8
Liver weight, left	0.1	0.2	0.5	-0.3	0.2	0.6	-0.7	-0.1
Liver weight, right	0.8	1.4	3.6	-1.0	1.9	-0.7	0.6	1.1
Locomotor activity	0.2	0.3	0.9	-0.9	0.6	-0.2	0.2	-0.4
Locomotor testing distance	0.3	0.6	0.9	1.0	0.4	-0.9	0.9	0.2
Locomotor testing rearing	0.1	0.1	0.3	-0.5	0.1	0.3	-0.3	-0.6
Locomotion in novel chamber	0.7	0.9	4.1	2.0	-0.3	-0.2	0.1	0.6
Locomotion in novel chamber post-restriction	0.7	1.1	3.1	1.8	-1.4	0.4	-0.5	-0.4
Fecal boli incidents, locomotor time 1	0.2	0.3	0.8	-0.1	0.9	-0.6	0.5	0.1
Change in fecal boli incidents, locomotor task	0.8	0.8	1.3	-0.7	1.1	-1.0	1.1	-0.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.9	-1.0	0.2	0.6	-0.6	-0.4
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.2	0.5	-0.3	0.3	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	0.4	-0.4	0.4	-0.1
Rest time, locomotor task time 1	0.5	0.6	1.1	-0.3	1.0	-0.9	0.9	0.5
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.5	-0.1	0.4	-0.4	-0.1
Vertical activity count, locomotor time 1	0.8	1.9	3.3	0.5	1.7	-1.3	1.2	1.8
Time >=10cm from walls, locomotor time 2	1.0	1.4	2.9	-0.7	1.7	-1.4	1.3	-0.0
Bouts of movement, locomotor time 2	1.1	1.7	4.2	1.2	-2.1	0.8	-0.7	-1.3
Total resting periods, locomotor time 2	1.3	2.3	5.6	1.0	-2.4	1.1	-1.1	-1.5
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.0	-0.1
Distance moved, locomotor task time 2	0.5	0.6	1.0	-1.0	1.0	-0.5	0.6	0.5
Vertical activity count, locomotor time 2	1.5	2.1	3.3	0.1	1.8	-1.6	1.8	1.1
Light reinforcement 1	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.4	-0.5
Light reinforcement 2	0.4	0.7	1.0	-0.4	-0.9	1.0	-0.9	-0.8
Bone: marrow area	0.8	1.8	6.9	-2.6	0.3	0.8	-0.7	-1.1
Bone: maximum diameter	1.1	2.0	6.8	-2.6	0.1	0.5	-0.6	-1.7
Bone: maximum force	0.7	1.2	2.7	-1.4	-0.5	0.6	-0.7	-1.6
Bone: maximum moment	0.7	1.2	2.7	-1.6	-0.4	0.6	-0.7	-1.6
Mean time between licks in bursts	0.9	2.3	3.7	-0.5	-1.9	1.4	-1.4	-1.9
Mean num. licks in bursts	0.6	0.9	1.6	0.0	1.3	-0.8	1.0	1.0
Cd content in liver	0.4	0.5	0.9	0.1	-0.3	0.9	-1.0	-0.7
Co content in liver	0.3	0.3	0.8	0.9	-0.5	0.0	-0.1	-0.7
Cu content in liver	1.4	1.6	5.5	2.3	-0.4	-1.1	1.1	0.2
Fe content in liver	1.5	1.8	8.0	-2.8	0.7	0.3	-0.3	-0.5
K content in liver	0.2	0.2	0.3	0.4	0.2	-0.6	0.5	0.3
Mg content in liver	0.2	0.2	0.4	0.4	0.4	-0.6	0.6	0.2
Mn content in liver	0.2	0.2	0.7	0.8	-0.5	0.4	-0.4	-0.2
Na content in liver	0.6	0.6	1.0	0.2	0.8	-1.0	1.0	0.7
Rb content in liver	0.1	0.1	0.4	-0.2	-0.1	-0.3	0.3	-0.6
Se content in liver	0.2	0.2	0.6	0.7	-0.6	0.4	-0.4	-0.3
Sr content in liver	1.8	1.6	5.4	2.3	-0.5	-0.7	0.6	1.2
Zn content in liver	0.2	0.2	0.5	0.7	0.4	-0.2	0.2	0.4
Bone: minimum diameter	0.2	0.4	0.7	-0.8	-0.3	0.6	-0.5	-0.6
Time in familiar zone, hab. session 1	0.3	0.3	1.0	-0.7	0.1	-0.3	-0.1	-1.0
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.5	0.0	0.6	-0.3	0.1
Total zone transitions, hab. session 1	0.5	0.7	2.8	1.7	-0.7	0.4	-0.1	0.1
Total locomotion distance, hab. session 1	0.2	0.3	1.5	1.2	0.0	0.0	0.0	0.3
Locomotion velocity, hab. session 1	0.3	0.5	2.1	1.5	-0.1	-0.1	0.2	0.4
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.4	0.2	-0.5	-0.1	-0.2
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.2	-0.3	0.6	-0.2	0.5
Total zone transitions, hab. session 2	0.1	0.2	0.5	0.7	0.2	-0.2	0.5	0.1
Total locomotion distance, hab. session 2	0.2	0.2	0.4	0.1	-0.5	0.7	-0.3	-0.4
Locomotion velocity, hab. session 2	0.0	0.1	0.1	0.2	-0.3	0.3	0.1	-0.3
Novel to familiar place preference ratio	0.3	0.4	1.1	-1.0	0.6	0.5	-0.2	0.3
Novelty place preference	0.3	0.3	0.9	-1.0	0.7	0.4	-0.1	0.3
Time in novel zone, NPP test	0.4	0.4	0.9	-0.9	0.8	0.4	-0.1	0.5
Total zone transitions, NPP test	0.3	0.4	1.8	1.4	-0.3	0.2	-0.2	0.1
Total locomotion distance, NPP test	0.1	0.1	0.2	0.0	-0.1	0.5	-0.4	0.0
Locomotion velocity, NPP test	0.1	0.1	0.1	0.4	-0.3	0.4	-0.3	-0.2
Intraocular pressure	0.5	0.8	1.7	-1.3	-0.0	0.8	-0.9	-0.8
Delta distance traveled before/after self-admin	3.1	3.2	7.7	-0.7	2.8	-1.8	1.9	1.2
Delta ambulatory time before/after self-admin	2.0	2.5	6.4	-0.9	2.5	-1.5	1.5	0.8
Parametrial fat weight	1.6	3.8	5.7	0.5	2.1	-2.4	2.4	1.7
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.2	-0.1	0.5	-0.5	-0.1
Pavlov. Cond. magazine entry latency	0.6	0.8	1.9	0.4	-1.4	0.5	-0.3	-1.3
Pavlov. Cond. change in total contacts	0.6	0.6	1.3	0.8	-1.1	0.4	-0.5	-0.8
Pavlov. Cond. index score	0.1	0.1	0.3	0.2	-0.4	-0.2	0.3	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.1	0.1	-0.3	-0.2	0.3	-0.4
Pavlov. Cond. lever contacts	0.3	0.4	0.8	0.6	0.1	-0.9	0.9	0.3
Pavlov. Cond. magazine entry number	0.3	0.3	0.7	-0.8	0.9	-0.1	-0.0	0.6
Pavlov. Cond. intertrial magazine entries	1.8	2.2	3.8	0.8	1.5	-1.4	1.5	2.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.3	-0.4	-0.2	0.3	-0.5
Pavlov. Cond. response bias	0.2	0.3	0.3	0.6	-0.6	-0.4	0.5	-0.5
Pavlov. Cond. lever latency	0.3	0.4	0.7	0.5	-0.6	0.6	-0.5	-0.8
Pavlov. Cond. magazine entry latency	0.3	0.4	1.1	1.0	-0.1	-0.3	0.2	0.9
Pavlov. Cond. change in total contacts	0.8	1.3	4.2	-2.1	1.1	-0.7	0.7	0.3
Pavlov. Cond. index score	0.4	0.5	1.0	-0.1	0.7	-0.8	0.6	1.0
Pavlov. Cond. latency score	0.6	0.8	1.5	0.0	0.8	-1.0	0.9	1.2
Pavlov. Cond. lever contacts	0.4	0.5	0.9	-0.3	0.8	-0.8	0.6	1.0
Pavlov. Cond. magazine entry number	0.3	0.3	0.9	-0.1	-0.5	0.6	-0.4	-1.0
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.7	0.1	0.6	-0.7	0.8	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.8	-0.2	0.5	-0.6	0.5	0.9
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.4	0.3	-0.3	0.2	0.5
Time in closed arm before self-admin	0.3	0.4	0.7	0.8	-0.1	-0.7	0.6	0.5
Time in closed arm after self-admin	0.7	0.8	0.9	0.9	0.8	-0.9	0.9	1.0
Time in open arm before self-admin	0.5	0.5	0.9	0.1	1.0	-0.8	0.8	0.6
Time in open arm after self-admin	0.0	0.0	0.0	0.1	0.0	-0.1	-0.0	0.1
Bone: periosteal estimation	0.7	1.6	4.8	-2.2	-0.1	0.6	-0.6	-1.5
Bone: periosteal perimeter	1.2	2.1	7.3	-2.7	0.5	0.2	-0.3	-1.7
Bone: post-yield work	0.3	0.5	1.4	-0.5	-0.6	0.4	-0.6	-1.2
Progressive ratio test 1 active lever presses	2.0	2.5	3.5	0.2	-1.9	1.8	-1.8	-1.6
Progressive ratio test 1 breakpoint	1.7	2.1	3.0	0.2	-1.7	1.7	-1.6	-1.5
Progressive ratio test 1 inactive lever presses	1.5	2.2	4.4	0.4	-2.1	1.6	-1.6	-1.0
Progressive ratio test 2 active lever presses	1.1	1.3	1.9	1.3	-1.4	1.0	-1.0	-0.8
Progressive ratio test 2 breakpoint	1.4	1.6	2.7	1.2	-1.6	1.2	-1.2	-1.0
Progressive ratio test 2 inactive lever presses	0.7	1.1	4.2	2.0	-1.0	0.3	-0.4	-0.1
Incentive Sensitization - Responses	0.2	0.3	1.5	1.2	-0.4	0.1	-0.1	0.1
Incentive Sensitization - Breakpoint	0.3	0.3	1.4	1.2	-0.5	0.2	-0.2	0.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.1	0.0
Progressive ratio	0.2	0.4	0.8	-0.4	-0.2	0.9	-0.8	0.3
Food seeking constrained by brief footshock	0.6	0.8	1.8	-0.3	-1.0	0.7	-0.7	-1.3
Seeking ratio, punishment vs. effort	0.2	0.3	1.2	0.2	-0.3	-0.4	0.3	-1.1
Retroperitoneal fat weight	0.5	2.0	7.5	-2.7	1.4	-0.5	0.4	0.1
Reaction time number correct	0.1	0.2	0.6	0.8	-0.2	0.1	0.3	-0.2
Reaction time mean minus median	0.0	0.1	0.2	-0.4	-0.1	0.3	-0.2	-0.1
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.3	0.2	0.1	-0.0	0.4
Reaction time num false alarms	0.0	0.0	0.1	0.3	0.2	-0.1	0.1	0.3
Reaction time num false alarms AUC	0.0	0.1	0.1	0.4	0.2	0.0	-0.0	0.4
Reaction time trials correct on left	0.1	0.2	0.6	0.8	-0.2	0.1	0.3	-0.2
Reaction time trials on left	0.1	0.2	0.8	0.9	-0.3	0.2	0.2	-0.3
Reaction time mean	0.1	0.2	0.4	-0.6	0.3	-0.4	0.4	0.2
Reaction time mean AUC	0.0	0.1	0.2	-0.4	0.2	-0.3	0.3	0.2
Median of all reaction times	0.1	0.2	0.4	-0.6	0.2	-0.4	0.5	-0.0
Reaction time omissions	2.6	3.8	6.9	0.8	-2.6	2.0	-2.0	-1.9
Reaction time false alarm rate	0.0	0.0	0.2	0.1	0.1	-0.0	-0.1	0.4
Reaction time premature initiation rate	0.1	0.1	0.3	-0.5	-0.0	-0.0	0.1	-0.3
Reaction time premature initiations	0.0	0.0	0.1	-0.1	0.0	-0.0	0.2	-0.1
Std. dev. reaction times	0.1	0.1	0.3	-0.6	0.4	-0.0	0.1	0.3
Reaction time trials completed	0.1	0.2	0.8	0.9	-0.3	0.2	0.2	-0.3
Reaction time trials AUC	0.1	0.1	0.4	0.7	-0.2	0.2	0.1	-0.3
Run reversals in cocaine runway, females	0.6	0.6	1.0	-0.2	1.0	-1.0	1.0	0.5
Run reversals in cocaine runway, males	0.6	0.6	0.9	-1.0	0.6	0.9	-0.7	0.5
Latency to leave start box in cocaine runway	1.8	2.0	2.5	-1.6	-1.3	1.5	-1.4	-1.3
Latency to leave start box in cocaine runway, F	1.4	1.6	2.6	-1.4	-1.2	1.1	-0.9	-1.6
Latency to leave start box in cocaine runway, M	0.5	0.5	0.9	-0.6	-0.4	0.9	-0.9	-0.2
Std. dev. time between licks in bursts	0.1	0.1	0.4	-0.6	0.3	-0.1	0.1	0.2
Total sessions with >9 infusions	1.9	2.3	3.1	-0.9	-1.4	1.8	-1.7	-1.6
Short access day 1 total inactive lever presses	0.4	0.5	1.9	-1.4	0.5	0.4	-0.4	0.1
Short access day 10 total inactive lever presses	2.2	5.3	9.4	-0.3	3.1	-2.5	2.5	2.1
Short access day 1 total infusions	0.1	0.1	0.3	-0.5	0.1	0.2	-0.1	-0.2
Short access day 10 total infusions	1.8	2.3	3.4	-0.7	-1.4	1.8	-1.8	-1.6
Short access total infusions	1.8	2.3	3.1	-0.4	-1.6	1.8	-1.7	-1.7
Short access day 1 locomotion	0.0	0.1	0.1	-0.1	0.2	0.4	-0.3	0.1
Short access day 10 total locomotion	0.8	1.6	2.6	1.1	0.8	-1.3	1.3	1.6
Short access total locomotion	0.1	0.1	0.1	0.2	-0.3	0.4	-0.4	0.2
One hour access (0.3 mA shock)	2.8	3.2	5.2	2.2	-2.3	1.4	-1.3	-1.4
Compulsive drug intake	1.0	1.2	2.1	1.4	0.6	-1.1	1.1	1.0
One hour access (shock baseline)	1.9	2.9	4.8	0.6	-2.2	1.9	-1.8	-1.6
Social response proportion	4.8	5.4	6.3	-1.6	-2.5	2.4	-2.5	-2.5
Social responses	1.1	1.5	2.0	-0.3	-1.4	1.3	-1.4	-1.3
Social time	0.7	1.0	1.9	1.3	-1.4	0.4	-0.5	-0.9
Soleus weight	1.6	4.8	7.8	1.7	1.7	-2.7	2.8	1.8
Bone: stiffness	0.3	0.5	1.2	-1.1	0.1	-0.3	0.0	-1.0
Tibialis anterior weight	1.1	3.6	11.6	3.4	-2.4	0.6	-0.5	-0.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.2	-0.6	0.7	-0.7	-0.1
Time to tail flick, vehicle, after self-admin	1.5	1.9	3.3	0.3	1.8	-1.3	1.4	1.6
Time to tail flick, test, before self-admin	0.7	0.7	1.2	1.1	-1.0	0.9	-0.8	-0.3
Time to tail flick, test, after self-admin	0.6	0.6	1.2	0.3	0.8	-1.0	1.1	0.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	-0.7	0.8	-0.2	0.3	0.5
Delta time to tail flick, test, before/after SA	1.3	1.3	2.2	0.8	0.9	-1.5	1.5	0.8
Tibia length	0.3	0.9	2.3	-1.5	0.1	0.0	-0.0	-1.4
Ambulatory time before self-admin	0.4	0.7	1.6	0.5	-1.3	0.7	-0.8	-0.4
Ambulatory time after self-admin	0.6	0.7	1.2	0.1	1.1	-1.1	1.0	0.2
Bone: tissue strength	0.1	0.1	0.4	-0.7	0.2	0.0	-0.1	-0.1
Total heroin consumption	1.1	1.3	1.9	0.2	-1.4	1.2	-1.3	-1.1
Bone: trabecular number	0.1	0.1	0.2	-0.3	0.3	-0.4	0.3	0.1
Bone: trabecular spacing	0.4	0.5	1.1	-0.6	0.4	-0.5	0.8	-1.1
Bone: trabecular thickness	0.5	0.6	1.8	0.6	0.3	-0.6	0.6	1.3
Bone: trabecular tissue density	1.0	1.5	2.4	0.8	0.9	-1.5	1.5	1.2
Water consumed over 24 hours	1.1	1.4	1.8	1.0	1.2	-1.2	1.3	1.2
Number of responses in last shaping day	2.6	2.9	5.8	0.6	-2.4	1.7	-1.6	-1.6