Hub : Genes

Mga

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative TSS XM_063284962.1 0.03 0.02 9.3e-03 0 0 0.01 -0 3.1e-01 9.3e-02 3.4e-02 5.0e-01
2 PL gene expression Mga 0.03 0.02 1.2e-03 0.02 0.02 0.02 0.02 5.9e-03 3.9e-03 3.3e-03 1.2e-03
3 NAcc alternative TSS XM_008762120.4 0.01 0.01 8.8e-03 0 0 -0 0 5.0e-02 6.1e-02 4.8e-01 1.1e-01
4 RMTg isoform ratio XM_008762120.4 0.11 0.07 7.3e-03 0.04 0.04 0.06 0.03 3.5e-02 2.8e-02 1.4e-02 5.2e-02
5 RMTg alternative TSS XM_008762120.4 0.13 0.08 1.5e-03 0.1 0.09 0.1 0.1 1.4e-03 2.0e-03 1.8e-03 1.2e-03
6 IC intron excision ratio chr3_127328375_127334111 0.09 0.05 2.2e-03 0.05 0.05 0 0.03 3.9e-03 4.9e-03 2.1e-01 1.8e-02
7 IC alternative TSS XM_063284962.1 0.09 0.06 5.1e-03 0.02 0.02 0.01 0.02 3.4e-02 4.6e-02 7.5e-02 3.7e-02
8 Brain gene expression Mga 0.11 0.07 5.6e-06 0.07 0.07 0.06 0.07 2.6e-07 4.4e-07 6.1e-06 5.7e-07
9 Brain alternative TSS XM_008762120.4 0.04 0.03 1.4e-04 0.04 0.04 0.01 0.03 2.9e-04 1.9e-04 1.3e-02 1.9e-03
10 Liver gene expression Mga 0.04 0.02 1.2e-04 0.03 0.02 0.02 0.02 2.9e-04 3.7e-03 1.6e-03 2.1e-03
11 PL alternative TSS XM_008762120.4 0.04 0.02 7.3e-04 0.01 0.03 0.03 0.02 1.3e-02 9.3e-04 5.5e-04 3.2e-03
12 NAcc gene expression Mga 0.02 0.01 1.3e-03 0.01 0 0.01 0.01 7.9e-03 7.9e-02 7.1e-03 3.8e-02
13 Adipose mRNA stability Mga 0.02 0.01 5.4e-03 0.01 0.01 0.01 0 5.1e-02 2.0e-02 1.8e-02 9.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.01.72.21.3-1.4-1.3-1.2-1.2-1.21.5-1.4-1.2-1.4-1.31.31.2
Area under the delay curve2.93.46.62.1-1.7-1.9-1.9-1.9-2.01.2-1.1-2.6-1.4-2.30.62.3
BMI with tail4.114.319.83.5-4.2-4.5-4.3-4.3-4.23.7-3.4-3.5-4.4-3.41.63.3
BMI without tail6.018.423.54.5-4.8-4.7-4.5-4.5-4.54.5-4.4-3.8-4.5-4.03.23.6
Body weight4.620.027.74.2-5.0-5.3-5.2-5.2-5.04.2-4.0-4.0-5.2-3.92.14.0
Weight adjusted by age0.71.12.51.1-1.1-1.2-1.5-1.6-1.60.4-0.6-0.9-1.0-0.50.00.9
Bone surface0.50.81.40.5-1.0-1.0-0.9-0.9-0.91.2-1.2-0.5-1.2-0.51.00.4
Bone volume0.51.01.70.5-1.1-1.2-1.1-1.1-1.11.3-1.3-0.7-1.1-0.50.80.4
Breakpoint value in progressive ratio session0.30.40.8-0.80.40.70.70.70.6-0.1-0.10.50.90.70.7-0.8
Number of licking bursts0.20.30.8-0.50.30.60.60.60.60.4-0.40.20.90.40.9-0.7
Context. condit. distance diff. score1.41.73.91.3-1.7-1.2-1.3-1.3-1.22.0-1.9-0.7-0.8-0.71.70.3
Locomotion velocity, session 11.31.42.4-0.71.61.31.41.41.4-1.51.40.51.20.4-0.9-0.2
Locomotion distance, session 10.40.50.90.11.00.90.90.90.8-0.80.70.20.8-0.1-0.20.0
Locomotion velocity, session 22.42.74.82.2-1.5-1.5-1.4-1.4-1.51.3-1.4-2.2-1.7-2.20.61.9
Locomotion distance, session 20.10.20.50.50.40.50.50.50.40.0-0.1-0.10.3-0.40.70.1
Locomotion velocity, session 30.30.31.10.5-0.6-0.6-0.5-0.5-0.50.5-0.6-1.0-0.5-0.6-0.30.4
Locomotion distance, session 30.30.31.2-0.1-0.50.10.10.10.11.1-1.0-0.10.40.50.4-1.1
Stereotopy head waving bouts, day 33.13.65.51.7-2.0-2.3-2.3-2.3-2.31.2-1.3-2.0-2.2-1.6-0.41.9
Stereotopy head waving duration, day 34.65.58.12.3-2.3-2.6-2.7-2.7-2.61.4-1.5-2.7-2.7-2.50.12.9
Locomotion velocity, session 70.40.51.30.8-0.9-0.6-0.6-0.6-0.51.1-1.1-0.6-0.2-0.20.3-0.2
Locomotion distance, session 70.20.30.80.1-0.10.40.30.30.40.5-0.60.50.60.50.9-0.9
Stereotopy head waving bouts, day 70.20.21.1-0.70.40.10.20.20.2-0.70.80.20.10.4-1.0-0.2
Stereotopy head waving duration, day 70.30.42.1-1.00.4-0.10.00.00.1-0.80.90.3-0.10.6-1.4-0.3
Locomotion velocity, session 84.04.87.32.7-2.4-2.3-2.3-2.3-2.22.1-2.0-2.4-2.0-2.30.92.0
Locomotion distance, session 81.01.43.21.6-1.3-0.8-0.8-0.8-0.81.7-1.7-0.8-0.5-0.91.80.4
Degree of sensitization distance0.80.81.9-0.91.00.90.80.80.8-1.21.11.40.70.9-0.3-0.5
Degree of sensitization stereotypy1.11.22.3-1.51.00.80.80.80.9-1.11.21.20.81.4-1.2-1.3
Conditioned locomotion1.82.02.61.6-1.6-1.4-1.4-1.4-1.41.6-1.5-1.2-1.2-1.41.41.3
Cocaine response after cond. corrected0.40.51.0-0.50.51.01.01.01.00.3-0.20.11.00.21.0-0.6
Cocaine response after cond. not corrected0.50.61.2-0.20.61.01.11.11.10.2-0.2-0.11.1-0.21.1-0.3
Cocaine response before conditioning0.10.10.40.60.2-0.2-0.1-0.1-0.0-0.40.4-0.3-0.1-0.5-0.50.6
Saline control response1.11.53.30.8-1.1-1.7-1.7-1.7-1.70.3-0.3-0.7-1.8-0.6-0.91.1
Bone: connectivity density0.20.41.30.5-0.5-0.7-0.7-0.7-0.60.10.0-0.4-1.1-0.60.00.9
Bone: cortical apparent density2.63.66.0-2.41.82.01.91.91.9-1.31.22.31.92.3-0.3-2.3
Bone: cortical area1.42.23.51.1-1.6-1.9-1.8-1.8-1.81.4-1.4-1.4-1.8-1.10.31.2
Bone: cortical porosity0.80.92.71.6-0.5-0.0-0.2-0.2-0.20.9-0.8-1.40.0-1.61.21.2
Bone: cortical porosity1.21.33.11.7-1.0-0.7-0.8-0.8-0.81.1-1.0-1.6-0.6-1.70.81.4
Bone: cortical thickness1.52.53.41.6-1.6-1.8-1.8-1.8-1.81.5-1.4-1.7-1.9-1.50.41.5
Bone: cortical thickness0.20.21.5-0.3-0.20.30.20.20.20.7-0.7-0.10.1-0.01.2-0.2
Bone: cortical tissue density2.53.55.8-2.41.71.91.91.91.9-1.31.22.21.92.3-0.3-2.3
Condit. Reinf. active minus inactive responses2.93.25.1-2.21.71.21.21.21.1-2.12.12.11.32.3-2.2-1.8
Condit. Reinf. active-inactive response ratio0.30.41.7-0.80.1-0.2-0.2-0.2-0.3-0.60.50.50.20.9-1.3-0.6
Condit. Reinf. active responses5.56.99.9-3.12.62.12.12.12.1-3.03.03.11.83.1-2.7-2.6
Condit. Reinf. inactive responses4.04.97.1-2.42.32.12.22.22.2-2.22.22.71.62.5-1.5-2.4
Incentive salience index mean4.45.48.5-2.72.51.81.91.91.8-2.92.82.61.82.6-2.6-2.0
Condit. Reinf. lever presses2.83.97.6-2.02.21.61.61.61.6-2.82.62.21.21.9-2.3-1.4
Condit. Reinf. active minus inactive responses0.10.20.8-0.50.1-0.0-0.1-0.1-0.1-0.40.30.9-0.50.6-0.1-0.3
Condit. Reinf. active-inactive response ratio0.10.10.7-0.50.10.1-0.0-0.0-0.0-0.10.20.8-0.20.6-0.0-0.5
Condit. Reinf. active responses0.20.30.8-0.7-0.0-0.3-0.4-0.4-0.3-0.40.40.9-0.60.8-0.4-0.4
Condit. Reinf. inactive responses0.30.31.3-0.70.0-0.5-0.5-0.5-0.4-0.70.70.5-0.30.6-1.1-0.1
Condit. Reinf. lever presses0.50.73.1-0.70.0-0.7-0.7-0.7-0.7-1.01.00.4-0.90.5-1.80.2
Condit. Reinf. lever reinforcers received0.30.41.2-0.90.3-0.1-0.2-0.2-0.1-0.90.81.1-0.50.9-0.8-0.4
Conditioned reinforcement - actives0.10.10.40.00.50.60.50.40.3-0.50.30.10.3-0.10.1-0.1
Conditioned reinforcement - inactives0.20.21.50.5-0.40.1-0.0-0.1-0.10.6-0.8-0.20.1-0.21.2-0.2
Conditioned locomotion0.30.41.50.30.2-0.2-0.3-0.3-0.3-0.80.8-0.5-0.3-0.6-1.20.9
Patch foraging indifference point 0 sec1.73.16.70.9-1.3-2.2-2.3-2.2-2.1-0.10.3-1.5-2.3-1.0-2.61.6
Patch foraging indifference point AUC2.02.93.9-1.91.81.72.01.91.8-1.61.51.61.91.7-1.0-1.6
Delay disc. indifference point, 0s delay0.40.41.50.10.1-0.6-0.5-0.6-0.5-0.70.7-0.6-0.3-0.4-1.20.8
Delay disc. indifference point, 16s delay0.70.82.60.9-0.7-0.8-0.8-0.8-0.80.5-0.4-1.6-0.4-1.20.21.1
Delay disc. indifference point, 2s delay0.30.40.70.6-0.7-0.8-0.8-0.9-0.90.7-0.5-0.4-0.4-0.30.10.2
Delay disc. indifference point, 24s delay0.40.51.2-0.30.80.60.70.80.7-1.11.00.10.90.1-0.50.0
Delay disc. indifference point, 4s delay1.92.03.81.8-1.2-1.4-1.3-1.4-1.41.0-0.9-1.9-0.9-1.90.71.8
Delay disc. indifference point, 8s delay4.95.89.92.4-2.4-2.7-2.7-2.7-2.71.6-1.6-3.1-2.1-2.60.52.7
Indifference point function ln k3.35.77.72.6-2.8-2.3-2.4-2.4-2.42.7-2.7-2.3-2.2-2.22.01.9
Indifference point function log k3.35.77.72.6-2.8-2.3-2.4-2.4-2.42.7-2.7-2.3-2.2-2.22.01.9
Patch foraging total patch changes 0 sec1.32.56.40.7-1.2-2.0-2.1-2.0-2.0-0.10.3-1.3-2.1-0.7-2.51.3
Patch foraging total patch changes 12 sec0.70.95.4-0.90.60.10.10.2-0.0-1.11.20.70.11.0-2.3-0.6
Patch foraging total patch changes 18 sec0.71.12.5-1.21.10.70.90.90.9-1.21.11.00.61.2-1.6-1.1
Patch foraging total patch changes 24 sec0.81.43.01.0-1.1-1.3-1.3-1.2-1.30.3-0.4-1.2-1.7-1.3-0.31.7
Patch foraging total patch changes 6 sec0.50.84.8-0.90.50.20.10.20.2-1.11.10.60.31.0-2.2-0.8
Patch foraging time to switch 0 sec0.91.83.9-1.41.51.00.80.90.8-1.92.01.40.61.2-2.0-0.8
Patch foraging water rate 0 sec0.30.72.00.3-1.2-0.8-0.8-0.8-0.71.4-1.3-0.4-0.50.01.0-0.2
Patch foraging water rate 12 sec0.40.95.80.3-0.60.20.10.10.21.4-1.6-0.10.3-0.02.4-0.7
Patch foraging water rate 18 sec1.11.73.71.3-1.4-0.9-1.0-1.0-0.91.9-1.8-1.4-0.6-1.21.90.7
Patch foraging water rate 24 sec0.40.51.8-0.6-0.5-0.1-0.1-0.2-0.01.2-1.10.40.10.90.9-1.4
Patch foraging water rate 6 sec1.11.63.8-1.20.61.31.31.31.40.3-0.31.31.41.41.3-2.0
Seeking ratio, delayed vs. immediate footshock0.30.32.20.0-0.30.30.0-0.1-0.20.5-0.90.60.40.51.5-0.5
Distance traveled before self-admin0.70.91.41.0-0.9-0.9-0.8-0.9-0.90.9-1.0-0.9-1.2-1.10.91.0
Distance traveled after self-admin0.10.10.3-0.50.10.10.10.10.20.10.00.50.10.40.4-0.4
Extensor digitorum longus weight0.41.62.21.2-1.5-1.4-1.4-1.4-1.41.4-1.4-1.4-1.4-1.00.40.8
Bone: elastic displacement0.10.11.2-0.10.0-0.2-0.2-0.2-0.3-0.30.4-0.2-0.10.0-1.10.1
Bone: elastic work0.40.51.6-0.1-0.5-0.9-0.9-0.9-1.00.00.0-0.4-0.80.1-1.30.2
Bone: endosteal estimation0.10.31.80.0-0.3-0.00.10.1-0.00.8-0.90.10.10.11.3-0.3
Bone: endosteal perimeter0.00.10.2-0.2-0.1-0.00.10.10.00.2-0.40.20.20.30.5-0.3
Epididymis fat weight0.82.74.22.1-1.7-1.7-1.6-1.6-1.61.5-1.4-2.0-1.7-1.90.61.6
Delta time in closed arm before/after self-admin0.10.10.50.10.10.20.20.10.10.4-0.30.40.40.40.4-0.7
Delta time in open arm before/after self-admin1.01.04.50.6-1.2-0.5-0.6-0.5-0.61.5-1.7-0.3-0.4-0.32.1-0.0
Diff in mean of infusions in LGA sessions0.50.71.3-0.90.80.50.60.60.5-1.10.81.00.51.1-0.8-0.8
Delay discount exponential model param2.62.95.6-2.01.61.71.71.71.7-1.21.12.41.12.2-0.7-2.2
Extinction: sum of active levers before priming0.30.40.7-0.50.70.90.70.70.7-0.60.70.20.80.4-0.4-0.4
Active lever presses in extinction session 60.10.10.20.40.10.20.10.10.1-0.00.1-0.40.3-0.4-0.10.4
Bone: final force0.30.40.80.1-0.8-0.9-0.8-0.8-0.80.8-0.9-0.1-0.70.40.1-0.4
Bone: final moment0.20.40.70.0-0.7-0.8-0.8-0.8-0.80.8-0.8-0.0-0.60.40.0-0.5
Food consumed during 24 hour testing period0.10.20.90.3-0.00.30.30.30.40.7-0.6-0.10.0-0.41.0-0.1
Glucose1.21.94.61.3-1.9-1.3-1.4-1.4-1.42.1-2.1-1.1-0.7-0.71.10.0
Heart weight4.26.58.22.8-2.7-2.7-2.7-2.7-2.82.5-2.7-2.2-2.9-2.31.82.3
Delay discount hyperbolic model param2.42.74.8-2.01.61.71.71.71.7-1.21.12.21.12.1-0.7-2.0
Intermittent access intake day 1-15 change0.51.05.20.7-1.0-0.2-0.2-0.3-0.21.7-1.7-0.5-0.6-0.62.3-0.0
Intermittent access intake escalation0.51.15.00.6-1.1-0.4-0.4-0.4-0.41.7-1.7-0.5-0.7-0.62.20.1
Intermittent access intake escalation 21.21.48.70.9-0.70.30.30.20.31.9-1.9-0.6-0.1-0.82.9-0.0
Intermitt. access day 1 inactive lever presses0.51.73.01.6-1.2-1.6-1.6-1.5-1.30.6-0.5-1.0-1.6-1.30.21.7
Intermitt. access day 15 inactive lever presses0.30.51.00.8-1.0-0.7-0.8-0.8-0.70.9-1.0-0.4-0.7-0.20.80.3
Intermitt. access escalation Index0.30.41.4-1.10.1-0.1-0.1-0.0-0.0-0.50.50.9-0.41.2-0.9-0.9
Intermittent access day 1 total infusions0.10.20.8-0.30.40.30.10.10.0-0.70.60.00.50.4-0.9-0.1
Intermittent access day 15 total infusions0.20.30.70.3-0.7-0.3-0.4-0.5-0.50.8-0.9-0.3-0.4-0.10.8-0.1
Intermittent access terminal intake (last 3 days)0.40.63.00.5-0.7-0.1-0.3-0.3-0.31.2-1.3-0.5-0.3-0.21.7-0.2
Intermittent access total infusions0.10.10.20.2-0.3-0.1-0.3-0.3-0.40.3-0.4-0.3-0.1-0.10.40.1
Intermittent access day 1 locomotion1.01.32.11.1-0.9-1.2-1.3-1.3-1.30.0-0.2-1.4-1.1-1.1-1.21.4
Intermittent access day 15 total locomotion0.61.23.41.1-1.2-0.6-0.7-0.8-0.81.4-1.5-0.9-0.6-0.91.90.7
Intermittent access total locomotion0.40.40.90.8-0.6-0.4-0.6-0.6-0.60.4-0.6-0.9-0.6-0.80.50.9
Intermittent access standard deviation0.30.62.30.7-0.7-0.2-0.3-0.3-0.11.4-1.2-0.5-0.5-0.31.5-0.2
Left kidney weight3.817.927.25.2-4.6-4.5-4.5-4.5-4.44.2-4.0-4.2-3.9-4.22.23.8
Right kidney weight5.525.135.56.0-5.3-5.4-5.3-5.3-5.34.5-4.4-5.0-5.0-5.12.45.0
Cocaine induced anxiety1.42.03.51.9-1.3-1.5-1.5-1.5-1.50.6-0.6-1.4-1.7-1.4-0.31.8
Post-drug Anxiety1.92.04.62.1-1.5-1.5-1.5-1.5-1.51.1-1.1-1.2-1.6-1.50.51.6
Baseline Anxiety0.10.10.4-0.10.10.20.20.20.20.2-0.20.50.30.20.2-0.6
Tail length2.07.711.03.0-3.2-2.7-2.7-2.6-2.73.2-3.3-2.1-2.5-2.43.22.1
Length with tail1.14.76.52.1-2.5-2.5-2.6-2.5-2.52.1-2.1-1.7-2.4-1.61.41.8
Length without tail0.51.72.81.0-1.4-1.5-1.6-1.6-1.51.2-1.1-1.2-1.7-0.90.51.0
Times rat made contact with spout0.40.50.80.5-0.6-0.9-0.9-0.9-0.90.4-0.3-0.8-0.7-0.4-0.20.6
Lifetime Intake0.00.00.10.0-0.1-0.0-0.2-0.2-0.30.1-0.1-0.40.0-0.10.20.2
Liver weight, left2.44.07.31.7-2.0-2.3-2.4-2.4-2.21.7-1.5-1.5-2.7-1.71.42.0
Liver weight, right2.13.75.81.6-2.1-2.3-2.4-2.4-2.31.5-1.5-1.9-2.2-1.50.21.8
Locomotor activity0.10.10.30.10.40.40.30.20.2-0.60.50.00.0-0.2-0.30.3
Locomotor testing distance0.20.30.8-0.30.60.70.50.50.4-0.90.70.30.40.3-0.9-0.3
Locomotor testing rearing0.91.72.7-1.01.51.61.41.41.4-1.31.21.41.11.2-0.8-1.4
Locomotion in novel chamber0.20.20.80.1-0.6-0.5-0.8-0.9-0.8-0.1-0.2-0.4-0.20.2-0.00.2
Locomotion in novel chamber post-restriction0.81.43.90.9-1.3-1.0-1.0-1.0-1.11.2-1.4-0.7-0.9-1.12.01.0
Fecal boli incidents, locomotor time 10.20.30.5-0.60.70.60.70.70.7-0.60.60.00.60.3-0.4-0.3
Change in fecal boli incidents, locomotor task2.12.13.11.6-1.7-1.5-1.5-1.5-1.71.6-1.8-1.1-1.5-1.10.70.9
Time >=10cm from walls, locomotor time 10.20.20.5-0.50.30.40.40.40.50.1-0.10.50.20.50.1-0.7
Bouts of movement, locomotor time 12.52.84.5-1.62.12.02.01.92.1-1.71.71.21.91.1-0.5-1.1
Total resting periods, locomotor time 13.03.45.0-1.82.22.12.12.02.2-1.91.91.51.91.4-0.9-1.4
Rest time, locomotor task time 10.20.20.5-0.50.40.20.30.30.2-0.60.40.50.00.5-0.7-0.5
Distance moved, locomotor task time 10.30.40.9-1.00.60.50.40.40.2-0.60.70.50.51.0-0.7-0.6
Vertical activity count, locomotor time 10.00.10.3-0.4-0.00.2-0.00.0-0.00.2-0.00.30.10.40.6-0.2
Time >=10cm from walls, locomotor time 24.87.010.92.4-2.9-3.3-3.2-3.3-3.31.9-1.9-2.0-3.2-2.11.12.6
Bouts of movement, locomotor time 20.10.21.1-1.00.1-0.0-0.0-0.00.2-0.10.30.5-0.40.60.1-0.2
Total resting periods, locomotor time 20.10.21.4-1.20.20.10.10.10.3-0.20.30.6-0.20.80.0-0.4
Rest time, locomotor task time 23.13.95.9-1.62.22.42.42.42.4-1.71.61.72.21.6-1.1-1.9
Distance moved, locomotor task time 21.11.32.90.8-1.2-1.5-1.5-1.5-1.70.6-0.5-0.9-1.2-0.8-0.01.1
Vertical activity count, locomotor time 21.21.73.30.5-1.6-1.8-1.8-1.8-1.81.2-0.9-0.7-1.5-0.50.60.8
Light reinforcement 10.82.013.0-0.90.2-1.0-1.1-1.1-1.2-1.81.60.6-0.71.1-3.6-0.0
Light reinforcement 21.21.93.0-1.51.61.21.21.21.0-1.71.51.51.61.5-1.2-1.1
Bone: marrow area0.10.31.60.1-0.4-0.2-0.1-0.1-0.10.8-0.9-0.0-0.1-0.01.3-0.1
Bone: maximum diameter0.40.71.40.4-0.9-1.1-1.1-1.1-1.20.8-0.9-0.5-1.2-0.30.20.5
Bone: maximum force1.11.93.31.1-1.6-1.8-1.7-1.7-1.81.3-1.3-1.0-1.7-0.70.20.8
Bone: maximum moment0.91.62.81.0-1.4-1.7-1.6-1.6-1.61.2-1.2-1.0-1.6-0.60.20.7
Mean time between licks in bursts0.10.20.50.30.40.50.70.70.70.10.1-0.20.3-0.50.50.2
Mean num. licks in bursts0.40.61.20.6-0.6-1.0-1.0-1.0-1.0-0.00.1-0.5-1.1-0.4-0.80.8
Cd content in liver0.20.20.60.0-0.5-0.6-0.5-0.5-0.40.3-0.3-0.2-0.30.10.80.1
Co content in liver0.60.61.50.8-0.8-0.7-0.6-0.6-0.70.9-0.7-1.2-0.5-1.00.80.8
Cu content in liver0.60.72.6-0.40.40.70.90.91.00.4-0.30.61.10.61.6-1.0
Fe content in liver5.26.39.4-3.12.62.32.42.42.4-2.22.43.02.22.9-1.5-2.8
K content in liver0.80.83.40.9-0.6-0.3-0.3-0.3-0.41.2-1.0-0.7-0.7-1.01.80.7
Mg content in liver1.31.35.60.7-1.2-0.6-0.6-0.6-0.61.9-1.7-0.8-0.8-0.82.40.2
Mn content in liver1.61.82.81.4-1.6-1.4-1.6-1.6-1.71.1-1.2-1.3-1.5-1.2-0.21.2
Na content in liver0.50.61.3-0.31.01.11.01.01.0-0.60.60.80.40.10.7-0.2
Rb content in liver4.95.77.62.4-2.8-2.5-2.4-2.4-2.52.6-2.5-2.4-2.2-2.02.31.8
Se content in liver0.10.10.3-0.1-0.2-0.3-0.1-0.1-0.10.5-0.40.00.10.3-0.1-0.5
Sr content in liver0.10.10.40.40.1-0.1-0.1-0.10.10.10.2-0.3-0.2-0.60.00.6
Zn content in liver1.51.73.0-1.21.11.41.61.61.5-0.30.31.41.21.11.7-1.4
Bone: minimum diameter2.13.85.12.0-2.0-2.2-2.1-2.1-2.21.5-1.5-2.3-2.1-2.10.52.2
Time in familiar zone, hab. session 11.01.01.8-0.91.21.31.41.41.3-0.60.70.81.20.40.7-0.5
Time in novel zone, hab. session 11.21.22.40.7-1.4-1.4-1.6-1.6-1.50.8-0.7-0.7-1.3-0.2-1.00.3
Total zone transitions, hab. session 10.20.30.50.20.70.70.60.60.5-0.70.50.10.3-0.50.50.6
Total locomotion distance, hab. session 10.20.20.70.50.50.60.30.30.3-0.60.5-0.20.2-0.70.20.8
Locomotion velocity, hab. session 10.30.41.00.30.80.80.50.50.5-1.00.9-0.00.3-0.7-0.00.8
Time in familiar zone, hab. session 20.10.10.6-0.80.20.20.20.20.1-0.30.20.30.10.50.0-0.2
Time in novel zone, hab. session 20.70.71.51.2-1.0-1.0-1.0-1.0-0.90.9-0.7-0.9-0.7-0.8-0.20.6
Total zone transitions, hab. session 20.30.41.70.90.00.20.20.20.20.2-0.3-0.6-0.0-1.11.30.9
Total locomotion distance, hab. session 20.10.10.50.6-0.0-0.1-0.1-0.1-0.10.00.0-0.3-0.1-0.70.50.7
Locomotion velocity, hab. session 20.10.10.40.40.20.10.10.10.1-0.30.3-0.1-0.0-0.60.30.7
Novel to familiar place preference ratio0.60.71.60.5-0.9-1.2-1.2-1.2-1.30.2-0.3-0.5-0.8-0.3-0.50.8
Novelty place preference0.70.71.60.5-0.9-1.1-1.2-1.2-1.30.2-0.4-0.5-0.8-0.4-0.50.8
Time in novel zone, NPP test0.50.61.50.4-0.9-1.1-1.1-1.1-1.20.2-0.3-0.4-0.6-0.3-0.50.7
Total zone transitions, NPP test0.40.62.80.90.20.70.70.70.70.4-0.5-0.50.4-1.01.70.5
Total locomotion distance, NPP test0.81.13.41.8-0.6-0.3-0.2-0.2-0.20.9-0.9-1.3-0.1-1.71.51.3
Locomotion velocity, NPP test0.81.13.61.9-0.5-0.3-0.2-0.2-0.20.9-0.9-1.4-0.2-1.81.41.4
Intraocular pressure1.31.84.9-1.71.41.11.01.01.0-1.61.70.90.91.4-2.2-1.1
Delta distance traveled before/after self-admin0.60.61.2-1.10.70.50.50.60.7-0.81.00.80.70.9-0.9-0.8
Delta ambulatory time before/after self-admin1.11.42.3-1.31.10.80.80.91.0-1.51.51.21.01.3-1.5-1.0
Parametrial fat weight0.10.30.90.60.1-0.5-0.4-0.5-0.5-0.50.5-0.2-0.7-0.4-0.90.7
Pavlov. Cond. lever latency0.20.20.8-0.3-0.6-0.3-0.2-0.2-0.30.9-0.7-0.1-0.30.30.5-0.5
Pavlov. Cond. magazine entry latency0.60.73.8-0.40.5-0.1-0.2-0.2-0.2-1.51.30.80.30.7-2.0-0.2
Pavlov. Cond. change in total contacts0.10.10.40.40.10.20.20.20.2-0.0-0.00.40.60.10.4-0.2
Pavlov. Cond. index score0.50.72.3-0.40.90.40.40.40.4-1.51.30.70.70.4-1.4-0.0
Pavlov. Cond. latency score0.40.52.2-0.10.80.20.10.10.1-1.51.30.40.30.1-1.40.4
Pavlov. Cond. lever contacts0.30.41.50.10.80.50.40.40.4-1.21.00.40.5-0.0-0.70.3
Pavlov. Cond. magazine entry number0.30.42.40.1-0.10.30.40.40.41.0-0.8-0.4-0.3-0.41.6-0.0
Pavlov. Cond. intertrial magazine entries0.81.02.5-1.50.61.01.11.11.10.1-0.11.10.21.30.5-1.6
Pavlov. Cond. lever-magazine prob. diff.0.50.61.8-0.30.90.50.50.50.5-1.31.20.70.90.4-1.1-0.1
Pavlov. Cond. response bias0.60.81.5-0.50.90.70.60.60.5-1.21.11.01.10.9-1.1-0.7
Pavlov. Cond. lever latency0.81.22.50.00.91.51.51.51.50.0-0.00.11.5-0.21.6-0.4
Pavlov. Cond. magazine entry latency0.70.83.3-1.20.3-0.3-0.3-0.3-0.3-0.90.91.2-0.21.5-1.8-1.0
Pavlov. Cond. change in total contacts0.30.51.5-0.90.2-0.2-0.2-0.2-0.1-0.70.61.2-0.21.2-1.1-0.8
Pavlov. Cond. index score0.60.72.5-1.0-0.1-0.6-0.6-0.6-0.6-0.50.51.0-0.51.4-1.6-0.9
Pavlov. Cond. latency score0.40.61.8-0.9-0.1-0.6-0.5-0.5-0.5-0.40.40.9-0.41.2-1.3-0.8
Pavlov. Cond. lever contacts0.91.22.9-0.3-0.8-1.5-1.5-1.5-1.5-0.20.20.0-1.50.3-1.70.3
Pavlov. Cond. magazine entry number0.40.61.80.9-0.00.40.30.30.30.5-0.5-1.10.2-1.31.21.0
Pavlov. Cond. intertrial magazine entries1.01.53.11.5-1.1-1.0-1.0-1.0-1.01.2-1.2-1.8-0.9-1.70.81.5
Pavlov. Cond. lever-magazine prob. diff.0.50.72.4-1.0-0.1-0.6-0.6-0.6-0.6-0.50.51.0-0.51.3-1.5-0.8
Pavlov. Cond. response bias0.81.13.3-0.7-0.6-1.3-1.3-1.3-1.2-0.40.40.6-1.31.0-1.8-0.3
Time in closed arm before self-admin2.53.14.5-2.12.11.71.81.81.8-1.92.01.71.41.6-1.3-1.5
Time in closed arm after self-admin2.42.63.7-1.81.81.41.61.51.6-1.51.61.91.31.9-0.9-1.9
Time in open arm before self-admin0.70.71.20.5-1.0-1.1-1.1-1.0-1.00.5-0.5-1.0-0.9-0.5-0.80.7
Time in open arm after self-admin2.52.76.11.5-2.1-1.4-1.5-1.4-1.52.3-2.5-1.4-1.0-1.12.10.7
Bone: periosteal estimation0.51.11.60.7-1.1-1.2-1.1-1.1-1.21.2-1.3-0.9-1.1-0.60.70.7
Bone: periosteal perimeter1.01.72.51.2-1.4-1.6-1.5-1.5-1.61.1-1.2-1.4-1.4-1.10.21.2
Bone: post-yield work0.30.52.61.1-0.30.10.10.10.10.8-0.9-0.40.1-0.81.60.5
Progressive ratio test 1 active lever presses0.20.20.5-0.70.50.50.30.30.2-0.70.60.40.40.7-0.3-0.3
Progressive ratio test 1 breakpoint0.20.20.4-0.60.50.50.30.30.2-0.60.60.40.40.6-0.2-0.2
Progressive ratio test 1 inactive lever presses0.10.10.3-0.30.30.30.20.20.2-0.50.40.50.30.6-0.1-0.3
Progressive ratio test 2 active lever presses0.20.30.7-0.90.40.50.40.30.1-0.50.20.70.50.9-0.3-0.7
Progressive ratio test 2 breakpoint0.20.20.6-0.80.20.30.30.2-0.1-0.30.10.60.30.8-0.2-0.6
Progressive ratio test 2 inactive lever presses0.00.10.30.2-0.4-0.2-0.2-0.3-0.50.2-0.5-0.1-0.10.20.2-0.2
Incentive Sensitization - Responses0.00.00.1-0.3-0.10.10.10.0-0.20.0-0.30.00.10.2-0.2-0.3
Incentive Sensitization - Breakpoint0.00.00.1-0.4-0.00.10.10.0-0.2-0.0-0.20.10.10.2-0.3-0.3
Sum of active levers in priming session hrs 5-60.30.31.00.00.00.60.50.60.50.3-0.40.30.80.21.0-0.5
Progressive ratio0.10.20.4-0.50.60.30.50.50.4-0.30.40.60.00.20.6-0.0
Food seeking constrained by brief footshock0.00.00.10.10.10.20.00.10.1-0.30.3-0.00.2-0.1-0.30.3
Seeking ratio, punishment vs. effort0.10.11.3-0.1-0.00.1-0.1-0.1-0.0-0.30.2-0.00.30.3-1.1-0.2
Retroperitoneal fat weight1.77.414.12.1-2.9-3.6-3.6-3.6-3.61.4-1.5-2.0-3.8-1.8-0.82.5
Reaction time number correct1.93.66.81.8-2.2-1.9-1.8-1.7-1.62.6-2.4-1.5-1.9-1.42.21.0
Reaction time mean minus median0.30.71.60.6-0.9-0.7-1.1-1.1-1.30.4-0.6-0.7-1.0-0.60.11.0
Reaction time mean minus median AUC1.02.55.01.3-1.8-1.7-2.0-2.0-2.21.0-1.4-1.3-1.8-1.20.21.6
Reaction time num false alarms0.00.10.30.3-0.0-0.2-0.1-0.1-0.2-0.10.2-0.1-0.3-0.1-0.60.1
Reaction time num false alarms AUC0.10.10.3-0.20.30.20.30.30.2-0.30.40.40.00.4-0.5-0.4
Reaction time trials correct on left1.93.66.81.8-2.2-1.9-1.8-1.7-1.62.6-2.4-1.5-1.9-1.42.21.0
Reaction time trials on left1.93.56.51.7-2.2-1.9-1.8-1.8-1.62.6-2.3-1.4-1.9-1.42.20.9
Reaction time mean1.22.03.7-1.91.31.31.21.31.2-1.51.21.71.31.8-0.7-1.5
Reaction time mean AUC0.61.02.2-1.50.80.90.80.80.7-1.10.81.20.81.4-0.6-1.0
Median of all reaction times3.24.56.9-2.62.12.02.12.12.1-2.11.82.42.22.5-1.0-2.2
Reaction time omissions0.40.61.30.5-0.6-1.0-1.1-1.1-1.0-0.10.1-0.5-0.9-0.3-1.00.7
Reaction time false alarm rate0.81.22.4-1.01.20.91.01.00.8-1.41.40.90.90.9-1.5-0.6
Reaction time premature initiation rate2.12.95.2-1.71.91.51.51.61.5-2.12.32.11.01.6-1.6-1.2
Reaction time premature initiations0.30.51.6-0.80.70.50.50.60.6-0.71.01.30.00.9-0.5-0.8
Std. dev. reaction times0.20.41.2-0.1-0.7-0.6-1.0-0.9-1.1-0.1-0.2-0.3-0.70.0-0.60.5
Reaction time trials completed1.93.56.51.7-2.2-1.9-1.8-1.8-1.62.6-2.3-1.4-1.9-1.42.20.9
Reaction time trials AUC1.42.75.71.4-2.0-1.7-1.6-1.5-1.42.4-2.2-1.1-1.7-1.02.10.6
Run reversals in cocaine runway, females0.80.83.91.2-0.7-0.2-0.2-0.1-0.11.3-1.4-0.5-0.0-0.92.00.2
Run reversals in cocaine runway, males0.70.71.6-0.60.81.01.11.11.3-0.50.50.70.80.6-0.8-0.9
Latency to leave start box in cocaine runway0.30.40.8-0.90.70.30.60.60.6-0.70.70.90.20.7-0.3-0.4
Latency to leave start box in cocaine runway, F0.20.20.5-0.40.70.50.70.70.6-0.50.60.30.3-0.0-0.10.1
Latency to leave start box in cocaine runway, M0.50.41.7-1.00.2-0.10.10.10.1-0.40.41.30.01.2-0.4-0.9
Std. dev. time between licks in bursts1.82.43.51.6-1.6-1.6-1.7-1.7-1.71.2-1.1-1.8-1.9-1.70.21.7
Total sessions with >9 infusions0.30.31.1-0.40.50.20.00.00.1-1.01.1-0.30.30.0-1.00.4
Short access day 1 total inactive lever presses2.12.74.92.2-1.5-1.5-1.5-1.5-1.51.4-1.3-2.0-1.6-2.21.01.9
Short access day 10 total inactive lever presses0.71.84.42.1-1.5-1.2-1.1-1.1-1.11.6-1.7-0.7-1.0-1.21.70.8
Short access day 1 total infusions0.10.10.30.10.30.30.20.20.2-0.30.3-0.50.3-0.4-0.20.4
Short access day 10 total infusions0.30.31.2-0.60.70.50.30.30.4-1.01.10.30.40.3-0.40.1
Short access total infusions0.10.10.5-0.50.50.30.10.10.1-0.60.7-0.20.30.1-0.50.2
Short access day 1 locomotion0.70.92.1-0.91.10.80.70.70.7-1.41.40.40.80.7-1.4-0.4
Short access day 10 total locomotion1.73.16.32.2-1.7-1.4-1.5-1.5-1.41.5-1.6-2.5-1.3-2.30.72.2
Short access total locomotion0.81.02.70.9-0.5-0.9-1.1-1.1-0.9-0.20.2-1.4-0.8-1.2-1.11.6
One hour access (0.3 mA shock)0.60.72.8-0.5-0.20.60.50.50.41.0-1.20.60.50.91.7-1.2
Compulsive drug intake0.20.31.0-0.3-0.50.0-0.00.00.10.9-1.00.2-0.20.40.9-0.7
One hour access (shock baseline)0.10.20.4-0.50.50.40.30.30.2-0.50.50.60.40.7-0.3-0.5
Social response proportion1.61.85.2-1.61.00.90.70.70.8-1.21.22.30.92.1-1.2-1.9
Social responses4.45.711.0-3.02.11.71.81.81.7-2.22.23.11.93.3-2.2-3.0
Social time0.40.61.9-1.40.50.40.50.50.4-0.50.41.2-0.01.2-0.6-1.1
Soleus weight0.30.81.9-1.40.70.60.70.70.6-0.90.81.10.41.3-0.6-1.2
Bone: stiffness0.61.01.90.9-1.1-1.3-1.2-1.2-1.20.9-0.9-0.6-1.4-0.60.50.8
Tibialis anterior weight0.20.62.0-1.30.40.30.30.30.3-0.30.31.20.01.4-0.3-1.4
Time to tail flick, vehicle, before self-admin0.40.51.60.3-0.5-0.7-0.7-0.6-0.60.1-0.1-0.9-0.5-0.9-0.51.3
Time to tail flick, vehicle, after self-admin0.20.20.40.0-0.5-0.4-0.3-0.4-0.40.7-0.6-0.6-0.6-0.40.50.4
Time to tail flick, test, before self-admin0.10.10.5-0.50.1-0.2-0.10.10.1-0.70.50.10.00.2-0.30.3
Time to tail flick, test, after self-admin0.30.30.80.3-0.6-0.8-0.7-0.6-0.60.2-0.3-0.5-0.9-0.50.00.8
Delta time to tail flick, vehicle, before/after SA0.80.82.10.6-1.0-0.7-0.6-0.8-0.71.4-1.5-0.3-0.8-0.31.3-0.1
Delta time to tail flick, test, before/after SA0.10.10.30.1-0.1-0.2-0.2-0.3-0.30.2-0.1-0.2-0.5-0.2-0.40.1
Tibia length1.02.84.31.8-1.3-2.1-1.9-1.9-1.90.4-0.3-1.7-2.0-1.7-1.22.0
Ambulatory time before self-admin0.60.91.60.9-0.9-1.0-0.9-1.0-1.00.8-0.9-1.0-1.3-1.00.51.1
Ambulatory time after self-admin0.40.50.9-0.90.60.50.60.60.6-0.50.50.90.70.9-0.3-0.9
Bone: tissue strength0.80.81.91.4-0.8-0.8-0.8-0.8-0.80.8-0.9-1.0-0.8-1.10.50.9
Total heroin consumption0.20.20.60.70.00.30.20.20.20.2-0.4-0.60.3-0.80.60.5
Bone: trabecular number1.52.54.51.6-1.8-1.4-1.4-1.4-1.32.1-2.1-1.1-1.5-1.32.00.9
Bone: trabecular spacing1.62.17.3-1.71.40.70.80.80.8-2.22.10.90.91.3-2.7-0.7
Bone: trabecular thickness0.50.60.9-0.90.60.90.90.90.80.00.00.90.80.70.9-0.9
Bone: trabecular tissue density1.72.56.3-0.31.22.02.12.12.10.4-0.31.02.10.42.5-1.2
Water consumed over 24 hours0.60.81.8-1.30.80.70.70.70.7-0.60.61.00.91.4-0.8-1.3
Number of responses in last shaping day0.50.51.9-0.40.80.50.40.30.5-1.11.20.40.30.3-1.4-0.4