Hub : Genes

Mfsd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Mfsd1 0.23 0.1 0.0e+00 0.1 0.13 0.12 0.13 3.5e-11 2.7e-14 2.7e-13 5.0e-14
2 IC gene expression Mfsd1 0.12 0.06 5.7e-06 0.1 0.13 0.11 0.12 6.3e-05 6.0e-06 2.6e-05 1.5e-05
3 BLA gene expression Mfsd1 0.07 0.04 8.1e-03 0.03 0.02 0.01 0.03 1.8e-02 2.6e-02 5.5e-02 1.3e-02
4 Adipose mRNA stability Mfsd1 0.1 0.06 2.2e-06 0.01 0.04 0.04 0.03 4.7e-02 7.2e-05 2.1e-05 2.2e-04
5 Brain mRNA stability Mfsd1 0.06 0.03 1.0e-05 0.05 0.04 0.04 0.04 1.2e-05 1.3e-04 1.8e-04 1.3e-04
6 NAcc gene expression Mfsd1 0.06 0.03 8.6e-14 0.1 0.09 0.09 0.09 1.4e-14 3.4e-13 5.6e-13 4.1e-13
7 NAcc mRNA stability Mfsd1 0.03 0.02 6.1e-04 0.02 0.02 0.02 0.02 1.1e-04 1.6e-03 7.9e-04 5.0e-04
8 BLA mRNA stability Mfsd1 0.08 0.05 2.2e-03 0.07 0.03 0.04 0.06 1.2e-04 1.3e-02 4.8e-03 3.8e-04
9 LHb mRNA stability Mfsd1 0.24 0.13 1.1e-03 0.07 0.09 0.1 0.08 8.1e-03 4.6e-03 1.9e-03 6.4e-03
10 IL mRNA stability Mfsd1 0.19 0.11 6.4e-03 -0.01 0.04 0 0.01 5.0e-01 4.9e-02 2.8e-01 1.6e-01
11 Brain gene expression Mfsd1 0.18 0.08 5.9e-15 0.18 0.16 0.17 0.17 2.5e-16 1.1e-14 2.6e-15 2.0e-15
12 Liver mRNA stability Mfsd1 0.05 0.03 1.7e-04 0.04 0.04 0.02 0.03 8.6e-05 4.5e-05 1.3e-03 2.1e-04
13 PL gene expression Mfsd1 0.1 0.04 3.8e-11 0.1 0.09 0.1 0.1 1.6e-11 4.8e-10 3.5e-11 9.7e-11
14 IL gene expression Mfsd1 0.37 0.16 2.1e-03 0.01 0.02 0.03 0.04 1.5e-01 9.1e-02 7.9e-02 3.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density2.85.226.95.2-3.7-2.8-2.31.41.51.51.12.11.31.5-0.31.4-0.8
Area under the delay curve0.20.30.50.50.20.3-0.4-0.5-0.5-0.50.60.50.7-0.70.6-0.60.5
BMI with tail0.93.35.40.61.41.6-1.7-2.1-2.3-2.3-1.5-0.22.3-2.02.2-2.31.1
BMI without tail0.42.35.92.4-0.31.1-0.3-0.6-0.5-0.50.22.12.1-2.21.4-1.82.2
Body weight0.62.74.60.11.71.9-1.3-2.0-1.9-1.9-1.30.51.8-2.21.9-2.11.2
Weight adjusted by age0.10.42.21.5-0.5-0.1-0.9-0.6-0.4-0.4-0.20.51.0-0.30.5-0.40.3
Bone surface1.32.514.03.7-1.7-1.3-2.8-0.6-0.4-0.4-0.70.22.30.31.10.2-0.8
Bone volume1.83.619.54.4-2.6-2.3-3.10.10.40.4-0.01.01.81.10.51.1-1.3
Breakpoint value in progressive ratio session0.10.20.8-0.90.60.40.5-0.3-0.3-0.3-0.6-0.90.0-0.10.3-0.30.1
Number of licking bursts0.30.94.62.1-0.9-0.8-1.6-0.3-0.3-0.3-0.5-0.31.50.00.90.1-0.5
Context. condit. distance diff. score2.12.66.02.0-2.4-1.70.51.81.81.82.01.6-0.81.4-1.51.2-0.1
Locomotion velocity, session 10.10.10.5-0.4-0.1-0.10.70.20.50.50.2-0.1-0.50.3-0.40.4-0.1
Locomotion distance, session 10.60.72.5-1.31.00.50.0-1.0-0.9-0.9-1.1-1.60.1-0.00.4-0.1-0.6
Locomotion velocity, session 20.40.52.20.2-0.4-1.1-0.5-0.10.20.2-0.2-0.4-0.20.9-0.31.2-1.5
Locomotion distance, session 21.11.63.2-1.71.80.8-0.5-1.5-1.6-1.6-1.8-1.70.4-0.30.9-0.4-0.8
Locomotion velocity, session 30.91.02.51.10.1-0.1-1.5-1.1-1.0-1.0-1.4-0.91.6-0.41.3-0.3-0.5
Locomotion distance, session 30.70.85.02.2-1.3-0.8-1.40.30.30.30.10.90.90.40.30.3-0.1
Stereotopy head waving bouts, day 30.30.41.71.3-1.0-0.9-0.60.20.20.20.2-0.00.40.6-0.10.6-0.5
Stereotopy head waving duration, day 30.50.62.21.5-1.2-1.1-0.70.30.40.40.50.30.30.8-0.20.8-0.7
Locomotion velocity, session 70.30.42.2-1.50.80.50.6-0.2-0.5-0.5-0.3-0.8-0.60.3-0.2-0.1-0.2
Locomotion distance, session 70.81.03.0-0.9-0.4-0.21.71.31.11.10.90.4-1.60.8-1.40.60.2
Stereotopy head waving bouts, day 70.60.61.9-0.10.50.0-0.9-1.3-1.0-1.0-0.7-1.40.8-0.20.70.0-0.8
Stereotopy head waving duration, day 71.41.74.1-0.21.10.5-1.4-2.0-1.7-1.7-1.4-1.81.5-0.81.5-0.5-0.7
Locomotion velocity, session 80.40.50.9-0.10.60.5-0.2-0.9-0.7-0.7-0.7-0.90.8-0.70.8-0.60.1
Locomotion distance, session 80.10.10.5-0.60.3-0.10.1-0.3-0.3-0.3-0.6-0.7-0.20.3-0.00.2-0.5
Degree of sensitization distance1.81.98.3-2.90.90.92.90.70.60.60.7-0.7-2.10.0-1.30.00.5
Degree of sensitization stereotypy0.50.52.0-0.90.80.2-0.4-1.1-0.9-0.9-0.7-1.40.3-0.10.40.1-0.9
Conditioned locomotion0.40.41.00.40.50.2-1.0-0.9-0.8-0.8-0.6-0.40.9-0.50.9-0.3-0.2
Cocaine response after cond. corrected0.50.72.1-0.80.50.91.30.60.50.50.81.0-0.7-0.7-0.4-0.81.4
Cocaine response after cond. not corrected0.50.72.0-0.91.01.30.8-0.2-0.3-0.3-0.20.10.0-1.30.4-1.31.4
Cocaine response before conditioning0.50.61.60.8-0.10.1-0.7-0.6-0.6-0.6-1.2-1.01.3-0.51.0-0.40.0
Saline control response1.92.76.51.40.50.9-1.9-1.8-1.6-1.6-2.1-1.22.6-1.52.2-1.60.7
Bone: connectivity density1.42.314.93.9-2.5-1.5-1.60.70.70.70.61.41.40.50.20.4-0.1
Bone: cortical apparent density3.96.110.70.4-2.2-1.62.03.33.33.33.12.9-2.82.0-2.91.90.2
Bone: cortical area1.11.87.82.8-0.9-0.6-2.4-1.2-1.0-1.0-0.90.02.2-0.31.3-0.4-0.5
Bone: cortical porosity1.92.03.9-1.51.90.9-0.7-1.9-1.6-1.6-1.9-2.00.9-1.01.4-0.7-0.5
Bone: cortical porosity2.22.44.9-1.11.90.9-1.0-2.2-1.9-1.9-2.1-1.91.3-1.21.7-0.8-0.6
Bone: cortical thickness0.61.05.42.3-1.5-1.2-1.10.30.40.40.51.00.70.6-0.10.5-0.4
Bone: cortical thickness1.11.48.73.0-1.4-0.9-1.9-0.3-0.2-0.2-0.20.31.8-0.20.90.1-0.4
Bone: cortical tissue density3.75.810.40.4-2.1-1.52.03.23.23.23.02.9-2.71.9-2.81.80.3
Condit. Reinf. active minus inactive responses2.93.35.3-1.42.32.2-0.3-2.0-2.1-2.1-2.1-1.71.4-1.91.9-2.01.0
Condit. Reinf. active-inactive response ratio2.52.74.8-1.52.21.7-0.5-2.0-2.1-2.1-1.9-1.91.1-1.41.6-1.40.2
Condit. Reinf. active responses4.45.68.4-1.62.92.9-0.3-2.6-2.8-2.8-2.6-2.11.8-2.62.4-2.81.5
Condit. Reinf. inactive responses1.21.53.8-0.71.22.01.0-0.6-0.9-0.9-0.7-0.50.6-1.70.9-1.91.9
Incentive salience index mean1.82.44.6-1.82.12.00.3-1.6-1.8-1.8-1.8-1.50.7-1.41.3-1.60.8
Condit. Reinf. lever presses0.71.04.1-2.01.41.21.2-0.6-0.8-0.8-0.9-1.3-0.4-0.40.2-0.70.4
Condit. Reinf. active minus inactive responses0.71.02.30.70.40.9-0.3-1.0-1.1-1.1-0.8-0.81.5-1.11.3-1.40.9
Condit. Reinf. active-inactive response ratio0.40.63.10.6-0.11.00.90.2-0.1-0.10.00.40.6-0.90.4-1.31.7
Condit. Reinf. active responses0.91.32.60.70.50.3-1.3-1.4-1.4-1.4-1.5-1.31.6-0.71.4-0.8-0.3
Condit. Reinf. inactive responses0.71.03.70.30.4-0.5-1.9-1.2-1.1-1.1-1.2-1.10.90.20.90.2-1.4
Condit. Reinf. lever presses2.33.35.7-0.92.01.9-0.5-2.1-2.1-2.1-2.4-1.81.8-2.02.1-2.00.8
Condit. Reinf. lever reinforcers received0.71.02.00.60.40.2-1.2-1.2-1.3-1.3-1.3-1.11.4-0.51.2-0.7-0.3
Conditioned reinforcement - actives0.00.20.9-0.6-0.1-0.21.00.30.30.30.2-0.2-0.60.5-0.50.2-0.1
Conditioned reinforcement - inactives0.20.61.5-1.11.21.00.5-0.8-0.8-0.8-0.9-0.40.1-0.70.5-0.90.6
Conditioned locomotion0.20.20.60.1-0.3-0.8-0.20.10.10.10.70.7-0.60.5-0.70.3-0.5
Patch foraging indifference point 0 sec0.31.04.32.0-1.2-0.9-1.40.10.30.30.72.10.30.7-0.2-0.10.1
Patch foraging indifference point AUC0.30.83.3-1.81.10.80.9-0.8-0.8-0.8-0.8-1.3-0.4-0.30.0-0.50.1
Delay disc. indifference point, 0s delay0.80.93.71.0-0.6-1.2-1.9-0.2-0.2-0.20.1-1.30.60.60.30.9-1.7
Delay disc. indifference point, 16s delay0.50.72.8-0.00.10.61.50.40.40.40.61.4-0.2-0.5-0.2-0.71.7
Delay disc. indifference point, 2s delay0.80.95.51.10.0-0.5-2.4-0.9-0.9-0.9-0.1-0.21.1-0.20.90.1-1.1
Delay disc. indifference point, 24s delay0.50.82.8-0.40.51.01.20.10.10.10.71.7-0.2-1.1-0.0-0.91.5
Delay disc. indifference point, 4s delay0.50.51.61.2-0.3-0.4-1.3-0.5-0.5-0.5-0.1-0.71.2-0.20.8-0.0-0.5
Delay disc. indifference point, 8s delay0.10.20.90.00.30.2-0.1-0.3-0.3-0.31.00.80.1-0.40.1-0.40.3
Indifference point function ln k0.20.51.00.9-0.7-0.7-1.00.70.70.70.61.0-0.30.9-0.40.7-0.4
Indifference point function log k0.20.51.00.9-0.7-0.7-1.00.70.70.70.61.0-0.30.9-0.40.7-0.4
Patch foraging total patch changes 0 sec0.30.84.21.7-0.9-0.7-1.30.10.30.30.62.00.30.5-0.1-0.20.2
Patch foraging total patch changes 12 sec0.10.20.60.5-0.7-0.40.30.20.40.40.60.7-0.20.0-0.4-0.10.4
Patch foraging total patch changes 18 sec0.10.31.01.0-0.40.0-0.4-0.4-0.2-0.20.10.80.6-0.50.3-0.70.6
Patch foraging total patch changes 24 sec0.10.21.01.0-0.7-0.6-0.6-0.3-0.2-0.2-0.10.50.50.40.1-0.1-0.2
Patch foraging total patch changes 6 sec0.20.40.90.70.00.1-1.0-0.8-0.7-0.7-0.50.60.6-0.20.5-0.70.3
Patch foraging time to switch 0 sec0.20.81.51.2-1.1-0.31.01.01.21.21.10.80.0-0.3-0.40.40.8
Patch foraging water rate 0 sec0.31.12.0-0.71.31.1-0.7-1.3-1.4-1.4-1.2-0.30.7-0.81.0-1.40.4
Patch foraging water rate 12 sec0.20.72.61.6-1.1-1.2-1.30.60.60.60.00.80.40.7-0.00.7-0.8
Patch foraging water rate 18 sec0.10.20.6-0.20.4-0.0-0.7-0.5-0.7-0.7-0.1-0.50.20.50.4-0.1-0.5
Patch foraging water rate 24 sec0.30.41.01.0-0.9-0.8-0.60.50.50.50.0-0.10.10.9-0.10.6-0.6
Patch foraging water rate 6 sec0.60.94.11.6-0.5-0.7-2.0-0.4-0.5-0.5-1.0-0.01.3-0.10.90.2-1.0
Seeking ratio, delayed vs. immediate footshock0.91.32.70.8-1.4-0.90.81.41.41.41.61.2-1.00.7-1.30.70.3
Distance traveled before self-admin0.20.41.6-0.9-0.0-0.31.30.40.50.50.5-0.2-0.90.2-0.80.4-0.2
Distance traveled after self-admin0.71.33.0-0.4-1.1-1.21.71.41.41.40.90.1-1.50.5-1.51.0-0.3
Extensor digitorum longus weight2.610.217.3-2.53.93.1-1.0-4.2-4.1-4.1-3.5-3.92.4-2.63.1-3.00.5
Bone: elastic displacement0.30.41.80.8-0.3-0.5-1.3-0.5-0.6-0.6-0.5-0.10.70.50.50.0-0.6
Bone: elastic work1.21.66.11.9-0.8-1.2-2.5-1.0-1.1-1.1-0.8-0.71.50.70.90.5-1.6
Bone: endosteal estimation1.02.45.61.40.50.5-2.0-1.9-1.8-1.8-1.8-0.82.4-1.12.0-1.1-0.0
Bone: endosteal perimeter0.92.25.81.80.0-0.1-2.2-1.7-1.6-1.6-1.7-1.22.4-0.81.8-0.6-0.6
Epididymis fat weight0.20.83.50.8-0.70.11.10.70.70.71.41.9-0.2-0.6-0.5-0.31.1
Delta time in closed arm before/after self-admin0.20.10.60.10.40.3-0.70.0-0.0-0.0-0.80.50.3-0.30.5-0.00.1
Delta time in open arm before/after self-admin0.30.31.3-0.2-0.2-0.7-0.5-0.1-0.1-0.10.6-0.6-0.41.1-0.50.6-1.2
Diff in mean of infusions in LGA sessions0.30.61.4-0.10.80.6-0.9-1.2-1.1-1.1-0.2-0.40.8-0.60.9-0.80.0
Delay discount exponential model param0.30.40.8-0.3-0.5-0.50.40.70.70.7-0.3-0.4-0.70.9-0.70.8-0.5
Extinction: sum of active levers before priming0.71.13.1-1.41.81.3-0.0-1.5-1.4-1.4-0.1-0.30.2-0.60.7-1.20.4
Active lever presses in extinction session 60.10.10.30.40.20.0-0.0-0.5-0.4-0.4-0.30.30.5-0.40.5-0.60.4
Bone: final force1.52.48.52.9-1.0-1.2-2.9-1.3-1.2-1.2-0.8-0.42.20.21.30.2-1.4
Bone: final moment1.52.59.23.0-1.2-1.4-3.0-1.2-1.1-1.1-0.7-0.42.10.41.20.3-1.5
Food consumed during 24 hour testing period0.30.62.1-0.6-0.20.21.40.90.80.80.90.5-1.10.3-0.9-0.10.7
Glucose0.91.44.01.5-0.01.0-0.0-0.30.10.1-0.11.41.5-2.01.2-1.42.0
Heart weight0.50.92.40.10.81.30.0-0.6-0.6-0.6-0.01.60.6-1.20.7-1.31.5
Delay discount hyperbolic model param0.40.50.9-0.5-0.5-0.50.60.80.80.8-0.3-0.3-0.90.9-0.90.8-0.5
Intermittent access intake day 1-15 change0.10.30.7-0.50.80.7-0.1-0.7-0.7-0.7-0.6-0.40.4-0.30.6-0.60.3
Intermittent access intake escalation0.00.20.4-0.30.60.5-0.1-0.5-0.5-0.5-0.4-0.30.3-0.20.5-0.40.1
Intermittent access intake escalation 20.00.00.10.00.00.20.30.00.00.0-0.0-0.10.10.10.1-0.10.3
Intermitt. access day 1 inactive lever presses0.22.04.1-2.01.81.91.8-1.0-1.0-1.0-1.3-1.00.1-1.60.7-1.61.5
Intermitt. access day 15 inactive lever presses0.31.65.5-2.31.91.20.4-0.9-0.9-0.9-2.2-1.9-0.1-0.80.7-0.5-0.1
Intermitt. access escalation Index0.30.83.9-2.00.8-0.20.4-0.2-0.2-0.20.1-1.4-1.10.7-0.60.6-1.3
Intermittent access day 1 total infusions0.10.41.4-0.70.80.80.8-0.4-0.4-0.4-0.8-0.00.2-1.20.4-0.80.8
Intermittent access day 15 total infusions0.20.51.3-1.11.00.90.9-0.6-0.6-0.6-0.5-0.3-0.0-1.10.3-0.80.7
Intermittent access terminal intake (last 3 days)0.30.51.1-1.00.90.70.6-0.7-0.7-0.7-0.8-0.70.2-0.90.5-0.60.3
Intermittent access total infusions0.20.21.1-1.10.80.40.5-0.3-0.3-0.3-0.5-0.3-0.3-0.60.1-0.20.0
Intermittent access day 1 locomotion0.10.20.6-0.60.30.30.8-0.0-0.0-0.0-0.20.3-0.3-0.6-0.1-0.40.6
Intermittent access day 15 total locomotion0.00.10.40.30.10.30.4-0.2-0.2-0.2-0.10.10.4-0.40.3-0.50.6
Intermittent access total locomotion0.10.10.20.20.10.10.0-0.3-0.3-0.3-0.20.30.3-0.40.3-0.40.4
Intermittent access standard deviation0.31.53.8-0.5-0.7-0.32.01.51.51.51.31.1-1.60.7-1.50.60.7
Left kidney weight0.21.55.12.1-1.5-1.0-1.20.70.80.81.72.3-0.01.0-0.60.50.0
Right kidney weight0.10.82.11.5-1.1-1.1-1.30.30.40.41.01.10.01.2-0.40.8-0.7
Cocaine induced anxiety0.20.61.1-0.2-0.7-0.80.91.01.01.00.70.1-1.00.2-1.00.9-0.5
Post-drug Anxiety0.20.31.0-1.00.2-0.30.20.20.20.2-0.4-0.5-0.60.3-0.40.6-1.0
Baseline Anxiety0.91.53.4-1.31.71.3-0.5-1.4-1.4-1.4-1.8-1.70.8-0.31.2-0.8-0.1
Tail length0.10.74.21.4-0.8-0.3-0.10.40.70.71.02.10.2-0.2-0.20.30.4
Length with tail0.10.30.9-0.40.70.3-0.9-0.8-0.6-0.6-0.5-0.00.2-0.10.40.1-0.7
Length without tail0.21.22.3-1.41.40.3-1.5-1.2-1.2-1.2-1.3-1.40.00.30.60.1-1.4
Times rat made contact with spout1.41.63.11.4-1.8-0.90.71.81.61.61.21.8-0.70.8-1.10.70.4
Lifetime Intake0.10.10.7-0.80.60.20.3-0.1-0.1-0.1-0.5-0.1-0.2-0.40.0-0.0-0.1
Liver weight, left1.01.73.8-0.81.40.9-0.6-1.8-1.6-1.6-1.5-1.91.1-1.21.3-0.9-0.2
Liver weight, right0.20.41.40.7-0.4-0.7-0.9-0.4-0.3-0.3-0.3-1.10.70.20.40.5-1.2
Locomotor activity0.40.71.7-0.11.00.6-1.0-1.3-0.9-0.9-1.0-0.00.9-0.91.1-0.60.0
Locomotor testing distance0.92.34.4-0.31.61.4-1.1-2.1-1.6-1.6-2.0-0.71.6-1.91.9-1.40.6
Locomotor testing rearing0.20.82.91.2-0.1-0.2-1.7-0.9-0.5-0.5-1.2-0.61.5-0.61.20.0-0.4
Locomotion in novel chamber1.82.55.2-0.6-1.0-1.8-0.11.31.31.32.10.3-2.02.3-1.91.9-2.0
Locomotion in novel chamber post-restriction0.30.92.3-0.0-0.6-1.3-0.60.70.70.70.90.4-0.91.2-0.91.3-1.5
Fecal boli incidents, locomotor time 10.30.73.2-0.60.60.80.8-0.1-0.1-0.11.51.8-0.6-0.2-0.4-0.61.0
Change in fecal boli incidents, locomotor task1.01.12.11.3-1.4-1.00.41.31.31.31.11.4-0.50.3-0.90.70.1
Time >=10cm from walls, locomotor time 11.72.15.60.7-1.4-1.20.51.61.61.61.82.4-1.51.2-1.71.2-0.2
Bouts of movement, locomotor time 10.60.73.50.1-0.0-1.0-1.8-0.4-0.4-0.4-0.0-0.1-0.21.1-0.20.9-1.9
Total resting periods, locomotor time 10.80.93.20.7-0.7-1.3-1.70.10.10.10.40.2-0.31.4-0.51.2-1.8
Rest time, locomotor task time 11.01.64.11.5-1.5-1.8-1.80.70.70.70.60.0-0.11.3-0.51.7-2.0
Distance moved, locomotor task time 10.41.24.8-1.00.91.61.9-0.2-0.2-0.20.11.0-0.1-1.30.2-1.52.2
Vertical activity count, locomotor time 10.10.82.8-1.71.11.21.6-0.3-0.3-0.3-0.30.1-0.5-1.10.0-0.91.1
Time >=10cm from walls, locomotor time 20.20.51.30.1-0.5-1.0-0.60.70.70.70.50.4-0.70.5-0.61.1-1.1
Bouts of movement, locomotor time 20.30.93.7-1.60.5-0.6-0.10.20.20.2-0.5-1.0-1.21.0-0.71.3-1.9
Total resting periods, locomotor time 20.20.73.2-1.20.4-0.6-0.50.10.10.1-0.7-1.1-0.80.8-0.41.1-1.8
Rest time, locomotor task time 20.81.35.21.9-1.3-1.4-2.30.00.00.0-0.5-0.20.81.10.21.1-1.7
Distance moved, locomotor task time 20.50.61.9-0.90.91.11.1-0.2-0.2-0.20.40.4-0.1-1.10.3-1.01.4
Vertical activity count, locomotor time 20.10.31.3-1.00.50.41.20.30.30.30.40.4-0.6-0.6-0.3-0.10.5
Light reinforcement 10.41.96.1-0.31.21.90.5-1.5-1.3-1.3-0.00.40.9-1.81.0-2.52.2
Light reinforcement 20.51.25.6-2.41.71.41.5-0.7-0.6-0.60.4-0.5-0.9-0.8-0.2-0.90.8
Bone: marrow area0.92.25.21.40.40.3-2.0-1.8-1.8-1.8-1.8-0.92.3-1.01.9-1.0-0.2
Bone: maximum diameter0.61.38.02.8-1.5-1.2-1.6-0.20.20.2-0.30.51.50.10.60.5-0.5
Bone: maximum force1.22.48.12.3-0.4-0.6-2.9-1.7-1.6-1.6-1.2-0.72.4-0.31.6-0.3-1.0
Bone: maximum moment1.12.28.12.3-0.6-0.8-2.8-1.5-1.4-1.4-1.1-0.62.10.11.4-0.2-1.1
Mean time between licks in bursts0.95.210.9-2.73.32.7-0.2-2.7-2.6-2.6-2.1-2.21.2-2.52.0-2.31.0
Mean num. licks in bursts0.51.44.2-1.2-0.20.32.11.31.21.21.21.2-1.80.4-1.40.20.8
Cd content in liver0.50.51.10.6-0.9-1.00.50.60.50.50.60.7-0.61.1-0.80.9-0.7
Co content in liver0.50.61.1-0.81.01.00.5-0.8-0.9-0.9-0.8-0.80.4-0.90.7-0.80.5
Cu content in liver0.70.81.4-0.21.10.9-0.8-1.1-1.0-1.0-1.1-0.31.0-1.11.2-0.80.3
Fe content in liver0.40.51.41.0-0.80.10.70.70.80.80.80.70.1-0.6-0.2-0.41.2
K content in liver1.21.22.8-0.41.00.0-1.7-1.5-1.4-1.4-1.3-1.10.80.01.00.0-1.1
Mg content in liver1.51.63.6-1.21.91.3-0.5-1.7-1.5-1.5-1.6-1.00.8-1.21.4-0.90.1
Mn content in liver0.30.41.30.30.30.8-0.1-0.4-0.3-0.30.10.30.6-1.10.6-1.01.2
Na content in liver0.50.62.61.1-0.0-0.2-1.6-0.7-0.6-0.6-0.4-0.21.2-0.40.9-0.1-0.3
Rb content in liver1.21.44.90.10.81.80.6-0.4-0.4-0.40.10.90.8-1.90.9-1.92.2
Se content in liver0.50.51.60.1-0.30.41.10.60.80.80.81.3-0.4-0.5-0.4-0.41.3
Sr content in liver1.81.63.0-0.5-1.0-1.31.01.31.41.41.10.3-1.61.5-1.61.7-1.0
Zn content in liver0.20.21.1-0.70.00.01.10.40.40.4-0.00.1-0.80.3-0.60.20.0
Bone: minimum diameter2.54.811.41.90.80.7-3.0-2.8-2.6-2.6-2.4-1.33.4-1.72.9-1.5-0.2
Time in familiar zone, hab. session 11.21.32.41.0-1.6-1.20.41.31.61.61.41.0-0.81.0-1.21.2-0.2
Time in novel zone, hab. session 10.60.71.30.50.60.5-1.1-0.9-1.0-1.0-0.7-0.11.1-0.71.1-0.80.1
Total zone transitions, hab. session 11.31.93.3-1.11.81.6-0.3-1.6-1.7-1.7-1.5-1.01.0-1.31.4-1.50.6
Total locomotion distance, hab. session 10.71.03.5-1.91.71.20.6-1.0-1.0-1.0-1.0-0.8-0.1-0.60.5-0.70.1
Locomotion velocity, hab. session 11.11.66.7-2.62.01.41.1-1.0-1.2-1.2-1.2-1.3-0.4-0.60.4-0.80.1
Time in familiar zone, hab. session 25.76.512.52.3-3.5-3.2-0.22.92.82.82.61.7-1.73.1-2.52.9-1.5
Time in novel zone, hab. session 23.84.16.6-0.92.62.2-0.8-2.5-2.4-2.4-2.1-1.01.9-2.52.4-2.30.9
Total zone transitions, hab. session 20.81.02.7-1.41.30.80.1-1.2-1.3-1.3-1.3-1.60.3-0.30.7-0.5-0.4
Total locomotion distance, hab. session 21.11.43.5-1.91.71.51.1-1.0-1.1-1.1-1.3-1.30.0-0.90.6-1.10.6
Locomotion velocity, hab. session 21.21.65.1-2.31.81.61.2-1.0-1.2-1.2-1.4-1.4-0.2-0.80.5-1.00.5
Novel to familiar place preference ratio0.81.02.2-0.71.20.5-1.3-1.2-1.4-1.4-1.5-1.00.6-0.21.0-0.3-0.7
Novelty place preference0.70.92.2-0.61.00.1-1.5-1.1-1.2-1.2-1.4-0.90.50.10.80.0-1.1
Time in novel zone, NPP test0.80.93.3-0.20.8-0.1-1.8-1.1-1.2-1.2-1.3-0.80.70.20.80.1-1.2
Total zone transitions, NPP test1.01.54.9-2.21.71.00.5-1.3-1.3-1.3-1.6-1.8-0.1-0.30.5-0.5-0.4
Total locomotion distance, NPP test0.71.05.3-2.31.50.60.7-0.7-0.9-0.9-1.1-1.2-0.70.2-0.00.1-0.8
Locomotion velocity, NPP test0.91.37.3-2.71.60.71.1-0.7-0.8-0.8-1.1-1.4-1.00.2-0.20.0-0.7
Intraocular pressure0.30.51.4-0.90.0-0.10.80.70.60.60.80.7-1.20.5-0.90.4-0.1
Delta distance traveled before/after self-admin2.12.33.91.0-2.0-1.60.61.81.81.81.81.3-1.41.3-1.81.4-0.3
Delta ambulatory time before/after self-admin1.62.85.11.1-2.2-2.10.42.02.02.01.91.0-1.51.6-1.91.7-0.8
Parametrial fat weight0.10.10.90.30.1-0.0-1.0-0.3-0.4-0.4-0.20.40.30.00.3-0.2-0.3
Pavlov. Cond. lever latency0.30.41.60.7-0.6-0.5-0.30.50.80.81.21.2-0.20.2-0.40.30.2
Pavlov. Cond. magazine entry latency0.10.10.40.6-0.5-0.20.20.40.30.30.20.60.10.1-0.10.20.1
Pavlov. Cond. change in total contacts0.70.84.2-1.50.51.02.10.60.30.30.00.0-0.9-0.3-0.6-0.51.1
Pavlov. Cond. index score0.00.10.20.0-0.3-0.20.50.40.20.2-0.2-0.0-0.20.2-0.20.3-0.1
Pavlov. Cond. latency score0.10.10.4-0.1-0.2-0.10.60.40.20.2-0.30.0-0.20.2-0.30.2-0.1
Pavlov. Cond. lever contacts0.40.51.6-1.10.80.50.3-0.5-0.8-0.8-1.2-1.20.0-0.20.3-0.2-0.3
Pavlov. Cond. magazine entry number0.10.21.0-1.00.70.50.4-0.20.00.00.1-0.2-0.4-0.4-0.0-0.30.3
Pavlov. Cond. intertrial magazine entries1.31.66.9-2.62.21.70.7-1.0-0.9-0.9-1.0-0.9-0.5-1.00.5-1.00.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.0-0.3-0.10.70.50.30.3-0.20.1-0.30.2-0.30.20.0
Pavlov. Cond. response bias0.10.20.9-0.20.1-0.10.0-0.3-0.5-0.5-0.7-0.90.20.30.10.2-0.6
Pavlov. Cond. lever latency1.31.82.81.0-1.7-1.6-0.11.51.51.51.51.4-1.11.5-1.41.5-0.7
Pavlov. Cond. magazine entry latency0.50.72.11.4-0.8-1.2-1.4-0.3-0.3-0.3-0.4-0.30.90.60.40.7-1.3
Pavlov. Cond. change in total contacts0.61.42.2-0.41.31.1-0.3-1.5-1.4-1.4-1.4-1.41.3-1.41.4-1.10.4
Pavlov. Cond. index score0.71.12.10.10.80.5-0.9-1.4-1.4-1.4-1.4-1.21.3-0.81.3-0.7-0.3
Pavlov. Cond. latency score0.71.12.00.20.80.5-1.0-1.4-1.4-1.4-1.4-1.11.4-0.81.4-0.7-0.3
Pavlov. Cond. lever contacts0.91.42.0-0.91.41.30.2-1.3-1.3-1.3-1.4-1.30.9-1.31.2-1.20.6
Pavlov. Cond. magazine entry number0.20.31.0-1.00.50.60.70.30.30.30.30.4-0.8-0.2-0.4-0.30.7
Pavlov. Cond. intertrial magazine entries0.10.20.8-0.90.50.30.50.20.40.4-0.00.3-0.7-0.1-0.30.10.2
Pavlov. Cond. lever-magazine prob. diff.0.50.81.40.00.70.5-0.6-1.2-1.1-1.1-1.2-1.01.1-0.81.1-0.6-0.1
Pavlov. Cond. response bias0.81.22.2-0.31.00.9-0.3-1.4-1.3-1.3-1.3-1.51.2-1.01.2-0.90.1
Time in closed arm before self-admin0.40.62.20.8-1.1-1.3-0.60.20.20.20.1-1.50.20.5-0.20.8-1.3
Time in closed arm after self-admin0.20.20.9-0.5-0.0-0.5-0.30.30.30.3-0.2-1.0-0.40.2-0.20.7-0.9
Time in open arm before self-admin0.91.12.8-0.01.01.30.0-0.7-0.7-0.7-1.01.00.9-1.71.1-1.31.5
Time in open arm after self-admin0.10.10.60.7-0.2-0.3-0.8-0.2-0.2-0.20.20.50.40.20.10.1-0.4
Bone: periosteal estimation1.33.18.12.30.00.1-2.7-2.1-1.9-1.9-1.9-0.72.8-1.02.2-1.1-0.3
Bone: periosteal perimeter0.91.96.62.6-0.8-0.8-2.5-1.2-1.1-1.1-1.0-0.42.1-0.01.3-0.1-0.9
Bone: post-yield work1.32.23.6-0.81.61.6-0.6-1.7-1.9-1.9-1.6-1.41.3-1.51.5-1.70.7
Progressive ratio test 1 active lever presses0.00.10.4-0.00.2-0.1-0.4-0.2-0.2-0.2-0.00.60.00.10.1-0.0-0.2
Progressive ratio test 1 breakpoint0.00.00.4-0.00.2-0.2-0.3-0.1-0.1-0.10.00.6-0.10.2-0.00.1-0.3
Progressive ratio test 1 inactive lever presses0.41.12.4-1.41.61.41.0-1.0-1.0-1.0-0.90.20.1-1.20.6-1.21.0
Progressive ratio test 2 active lever presses0.91.32.60.40.91.30.2-1.1-1.1-1.10.00.91.2-1.51.2-1.61.6
Progressive ratio test 2 breakpoint1.01.32.70.50.91.30.2-1.1-1.1-1.10.00.91.3-1.61.2-1.71.6
Progressive ratio test 2 inactive lever presses0.00.10.5-0.00.10.10.4-0.2-0.2-0.20.40.7-0.1-0.1-0.1-0.30.3
Incentive Sensitization - Responses0.92.54.80.51.41.9-0.1-1.8-1.8-1.8-0.30.52.0-2.21.9-2.21.8
Incentive Sensitization - Breakpoint1.02.44.50.51.41.8-0.1-1.7-1.7-1.7-0.40.51.9-2.11.8-2.11.7
Sum of active levers in priming session hrs 5-61.21.24.6-1.71.21.42.1-0.4-0.4-0.4-0.3-0.2-0.5-0.90.1-1.11.6
Progressive ratio0.20.52.00.70.00.80.30.10.10.1-0.10.90.8-1.30.7-0.81.4
Food seeking constrained by brief footshock0.30.41.2-0.1-0.3-0.9-0.60.20.20.21.00.0-0.60.9-0.60.8-1.1
Seeking ratio, punishment vs. effort0.20.51.7-0.90.2-0.7-0.3-0.2-0.2-0.20.2-0.6-0.91.1-0.60.6-1.3
Retroperitoneal fat weight0.73.18.21.30.62.00.3-1.1-1.3-1.3-0.40.72.2-2.91.8-2.82.9
Reaction time number correct1.03.66.72.3-2.6-2.5-0.71.72.02.01.91.9-0.72.1-1.51.9-1.3
Reaction time mean minus median0.53.15.5-1.32.02.20.7-1.8-1.7-1.7-1.9-1.91.4-2.31.7-1.91.3
Reaction time mean minus median AUC0.96.09.3-2.13.03.01.1-2.6-2.5-2.5-2.7-2.41.8-3.12.4-2.61.5
Reaction time num false alarms0.91.57.22.7-0.6-0.4-2.4-0.9-0.7-0.70.11.01.9-0.31.2-0.60.1
Reaction time num false alarms AUC0.61.47.02.6-0.7-0.5-2.3-0.8-0.6-0.60.00.81.8-0.21.1-0.3-0.1
Reaction time trials correct on left1.03.66.72.3-2.6-2.5-0.71.72.02.01.91.9-0.72.1-1.51.9-1.3
Reaction time trials on left1.03.36.32.3-2.5-2.4-0.71.71.91.91.81.9-0.72.0-1.41.8-1.2
Reaction time mean1.02.34.1-1.31.81.80.3-1.5-1.5-1.5-2.0-1.91.1-1.81.5-1.50.9
Reaction time mean AUC1.53.66.1-1.72.32.20.3-2.0-2.0-2.0-2.5-2.31.3-2.11.8-1.90.9
Median of all reaction times0.91.52.9-1.21.51.40.0-1.2-1.3-1.3-1.7-1.50.8-1.31.1-1.20.5
Reaction time omissions3.15.19.6-1.62.93.10.1-2.3-2.2-2.2-2.4-1.51.8-2.82.4-2.62.0
Reaction time false alarm rate1.21.74.11.30.50.9-1.6-1.5-1.5-1.5-0.7-0.12.0-1.31.7-1.40.8
Reaction time premature initiation rate0.40.61.71.1-1.3-1.2-0.60.70.60.60.2-0.70.11.0-0.40.9-0.8
Reaction time premature initiations0.82.56.02.2-2.4-2.3-0.91.41.51.51.00.4-0.21.9-1.01.8-1.4
Std. dev. reaction times1.13.88.4-1.22.11.8-0.3-2.1-2.1-2.1-2.9-2.81.8-2.02.1-1.60.4
Reaction time trials completed1.03.36.32.3-2.5-2.4-0.71.71.91.91.81.9-0.72.0-1.41.8-1.2
Reaction time trials AUC0.93.15.72.2-2.4-2.4-0.71.61.91.91.72.0-0.71.9-1.31.7-1.1
Run reversals in cocaine runway, females0.40.43.0-1.70.90.40.6-0.2-0.2-0.20.5-0.2-1.00.1-0.5-0.0-0.3
Run reversals in cocaine runway, males0.10.10.5-0.5-0.0-0.00.60.10.10.10.70.3-0.70.2-0.50.10.1
Latency to leave start box in cocaine runway0.40.63.3-0.10.00.91.40.40.40.4-0.10.6-0.1-0.8-0.0-0.81.8
Latency to leave start box in cocaine runway, F0.40.62.50.9-0.50.40.60.50.50.50.51.50.0-0.3-0.2-0.61.6
Latency to leave start box in cocaine runway, M0.80.71.9-1.20.81.11.4-0.3-0.3-0.3-0.6-1.2-0.0-1.10.3-0.81.0
Std. dev. time between licks in bursts3.66.79.9-1.02.92.9-0.8-3.2-3.0-3.0-2.7-2.22.5-3.13.0-3.01.6
Total sessions with >9 infusions0.40.51.0-0.61.00.7-0.0-0.7-0.7-0.7-1.00.60.3-0.90.7-0.80.6
Short access day 1 total inactive lever presses0.10.10.7-0.30.40.1-0.1-0.5-0.5-0.5-0.10.8-0.1-0.2-0.0-0.40.1
Short access day 10 total inactive lever presses0.21.33.0-0.21.01.50.5-1.2-1.2-1.2-0.7-0.11.0-1.51.1-1.71.6
Short access day 1 total infusions0.10.30.9-1.00.50.10.80.30.30.3-0.40.8-0.8-0.2-0.40.00.2
Short access day 10 total infusions0.10.20.7-0.40.5-0.1-0.8-0.3-0.3-0.3-0.9-0.30.1-0.20.30.2-0.8
Short access total infusions0.20.31.2-0.60.70.3-0.3-0.5-0.5-0.5-1.1-0.20.2-0.60.5-0.2-0.2
Short access day 1 locomotion0.10.10.60.8-0.4-0.4-0.50.10.10.1-0.60.50.30.10.20.00.0
Short access day 10 total locomotion0.31.32.50.6-1.3-1.10.81.41.41.41.41.6-1.11.1-1.30.80.2
Short access total locomotion0.10.20.70.6-0.5-0.6-0.40.30.30.30.10.8-0.10.1-0.20.3-0.2
One hour access (0.3 mA shock)0.20.21.20.20.20.40.3-0.2-0.2-0.20.61.10.1-0.50.1-0.60.8
Compulsive drug intake0.71.13.01.30.30.5-1.7-1.2-1.2-1.2-0.1-0.31.7-0.71.4-0.90.1
One hour access (shock baseline)0.10.41.9-0.80.20.21.40.40.40.40.20.9-0.8-0.1-0.5-0.10.6
Social response proportion0.30.42.0-0.20.2-0.6-1.1-0.3-0.5-0.5-0.2-0.6-0.11.0-0.00.4-1.4
Social responses0.40.62.11.5-0.8-0.8-1.4-0.2-0.3-0.30.1-0.10.80.80.30.4-0.9
Social time0.10.10.90.0-0.10.1-0.00.1-0.1-0.10.90.4-0.20.2-0.3-0.10.1
Soleus weight0.61.73.61.5-1.6-1.9-1.41.01.01.00.91.0-0.51.7-0.91.7-1.5
Bone: stiffness0.30.52.20.7-0.1-0.6-1.5-0.7-0.6-0.6-0.4-0.30.80.10.50.5-1.1
Tibialis anterior weight0.20.61.00.7-1.0-0.60.30.80.90.91.01.0-0.60.8-0.80.40.1
Time to tail flick, vehicle, before self-admin0.30.41.31.1-0.30.4-0.1-0.2-0.2-0.2-0.50.60.9-0.70.7-0.71.1
Time to tail flick, vehicle, after self-admin1.12.24.1-1.12.02.00.2-1.6-1.6-1.6-0.80.90.7-1.81.3-2.01.7
Time to tail flick, test, before self-admin1.01.12.7-0.61.11.30.7-1.2-1.1-1.1-0.6-0.10.7-1.20.9-1.61.5
Time to tail flick, test, after self-admin0.20.20.9-0.2-0.2-0.40.30.40.40.41.00.4-0.70.4-0.60.3-0.0
Delta time to tail flick, vehicle, before/after SA0.30.42.0-1.41.10.50.2-0.4-0.4-0.40.40.6-0.8-0.1-0.3-0.2-0.1
Delta time to tail flick, test, before/after SA0.60.71.50.4-0.8-0.70.21.11.11.11.21.2-0.90.4-0.90.9-0.2
Tibia length0.10.20.9-0.90.6-0.1-0.4-0.3-0.3-0.3-0.3-0.1-0.60.6-0.20.5-0.9
Ambulatory time before self-admin0.10.21.4-0.90.40.21.2-0.10.00.00.1-0.3-0.3-0.4-0.1-0.20.3
Ambulatory time after self-admin1.82.84.70.4-2.0-2.01.62.12.22.21.60.4-1.81.2-2.11.7-0.7
Bone: tissue strength0.10.10.5-0.70.3-0.1-0.1-0.1-0.0-0.0-0.00.1-0.60.5-0.30.3-0.5
Total heroin consumption0.30.32.20.2-0.1-0.6-0.5-0.4-0.4-0.4-0.3-1.50.40.20.20.3-1.0
Bone: trabecular number3.05.730.45.5-3.8-2.9-2.81.31.31.31.02.11.51.5-0.11.5-1.0
Bone: trabecular spacing1.92.817.9-4.22.51.21.7-0.8-0.8-0.8-0.9-2.3-1.5-0.4-0.30.0-0.6
Bone: trabecular thickness5.47.522.04.7-4.2-3.5-1.62.52.62.62.33.0-0.22.5-1.62.5-1.2
Bone: trabecular tissue density0.30.62.0-1.40.60.31.20.50.60.60.50.7-1.30.2-0.80.30.1
Water consumed over 24 hours0.30.63.51.9-1.4-0.8-0.40.60.60.60.50.90.50.5-0.10.20.1
Number of responses in last shaping day0.40.51.70.1-0.5-0.21.10.80.80.80.71.3-0.60.0-0.70.10.6