Hub : Genes

Mettl21a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Mettl21a 0.12 0.11 4.5e-05 0.08 0.08 0.08 0.08 3.1e-05 4.1e-05 3.4e-05 3.5e-05
2 pVTA alternative TSS NM_001399451.1 0.03 0.02 2.3e-03 0.04 0.04 0.04 0.04 1.8e-04 6.9e-04 2.6e-04 2.3e-04
3 NAcc gene expression Mettl21a 0.08 0.07 1.5e-05 0.02 0.02 0.02 0.02 8.0e-04 2.2e-04 1.2e-03 1.6e-03
4 Liver gene expression Mettl21a 0.06 0.05 1.8e-05 0.03 0.03 0.03 0.03 1.4e-04 1.2e-04 4.3e-04 1.7e-04
5 pVTA isoform ratio NM_001399451.1 0.03 0.03 8.3e-03 0.02 0.03 0.03 0.02 4.6e-03 2.8e-03 4.1e-03 4.4e-03
6 PL gene expression Mettl21a 0.06 0.07 6.7e-04 0.02 0.03 0.02 0.02 3.4e-03 9.1e-04 1.7e-03 1.5e-03
7 LHb gene expression Mettl21a 0.16 0.11 3.5e-04 0.05 0.12 0.06 0.1 2.9e-02 8.3e-04 1.4e-02 3.0e-03
8 Liver intron excision ratio chr9_73478872_73479971 0.03 0.03 8.1e-04 0.02 0.02 0.03 0.02 9.1e-04 1.0e-03 8.1e-04 1.0e-03
9 Brain mRNA stability Mettl21a 0.04 0.05 5.7e-04 0.03 0.03 0.03 0.03 2.0e-03 5.5e-04 1.6e-03 5.3e-04
10 Brain gene expression Mettl21a 0.06 0.06 7.5e-06 0.06 0.05 0.05 0.05 7.0e-06 2.3e-05 8.0e-06 1.1e-05
11 OFC gene expression Mettl21a 0.14 0.11 2.6e-03 0.04 0.05 0.06 0.02 4.0e-02 2.5e-02 2.0e-02 9.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.10.10.2-0.30.3-0.5-0.40.4-0.4-0.4-0.3-0.3-0.2-0.5
Area under the delay curve0.10.10.20.4-0.40.30.3-0.30.20.30.20.20.40.2
BMI with tail8.027.533.35.8-5.64.65.4-5.15.05.15.25.05.84.9
BMI without tail3.09.210.33.1-3.22.83.1-3.02.93.03.23.13.22.8
Body weight0.20.81.51.2-1.20.50.9-0.80.80.80.80.71.20.7
Weight adjusted by age0.91.43.1-0.50.7-1.8-1.01.3-1.4-1.3-1.3-1.3-0.2-1.4
Bone surface0.40.71.4-0.40.7-1.2-0.80.9-1.0-0.9-0.9-0.9-0.4-1.0
Bone volume0.81.51.8-1.11.2-1.3-1.21.3-1.3-1.3-1.2-1.3-0.9-1.3
Breakpoint value in progressive ratio session2.53.04.3-1.42.0-2.1-1.71.8-1.9-1.8-1.6-1.6-1.4-1.8
Number of licking bursts0.20.30.50.3-0.20.70.5-0.60.70.60.60.70.20.6
Context. condit. distance diff. score1.11.32.50.7-1.01.61.1-1.31.41.31.21.20.51.2
Locomotion velocity, session 11.31.42.0-1.31.4-1.1-1.31.2-1.2-1.2-1.0-1.0-1.2-1.0
Locomotion distance, session 10.10.10.3-0.30.5-0.5-0.40.4-0.4-0.4-0.1-0.10.0-0.2
Locomotion velocity, session 20.10.10.50.10.4-0.7-0.30.4-0.5-0.4-0.3-0.3-0.1-0.3
Locomotion distance, session 20.00.10.20.3-0.1-0.10.1-0.10.00.10.30.40.40.3
Locomotion velocity, session 30.60.60.70.8-0.90.70.8-0.80.80.80.80.80.70.8
Locomotion distance, session 31.61.82.3-1.41.2-1.2-1.31.3-1.3-1.3-1.4-1.3-1.5-1.3
Stereotopy head waving bouts, day 32.12.42.91.7-1.51.41.6-1.61.51.61.61.61.51.6
Stereotopy head waving duration, day 32.22.73.92.0-1.51.31.7-1.61.51.61.61.61.91.5
Locomotion velocity, session 70.00.00.20.1-0.0-0.00.1-0.10.10.10.20.20.40.1
Locomotion distance, session 70.50.71.2-0.60.7-1.1-0.80.9-0.9-0.9-0.8-0.8-0.4-0.8
Stereotopy head waving bouts, day 70.30.30.50.4-0.40.70.6-0.60.60.60.60.60.20.7
Stereotopy head waving duration, day 72.42.93.51.6-1.41.91.7-1.81.81.81.81.81.31.8
Locomotion velocity, session 80.10.10.20.2-0.30.40.3-0.40.40.40.40.30.40.3
Locomotion distance, session 80.30.40.80.3-0.40.90.6-0.70.80.70.80.80.30.7
Degree of sensitization distance0.30.30.90.8-0.50.30.5-0.40.40.50.60.50.90.5
Degree of sensitization stereotypy0.80.91.40.7-0.81.21.0-1.01.01.01.01.00.51.1
Conditioned locomotion1.31.52.2-1.11.3-1.5-1.31.3-1.4-1.3-1.2-1.3-0.3-1.2
Cocaine response after cond. corrected1.31.61.9-1.11.1-1.4-1.21.3-1.3-1.3-1.3-1.3-1.3-1.2
Cocaine response after cond. not corrected1.51.82.6-1.41.4-1.2-1.31.3-1.3-1.3-1.3-1.3-1.6-1.2
Cocaine response before conditioning0.10.20.5-0.30.00.70.2-0.40.50.30.30.4-0.40.4
Saline control response0.30.42.00.9-0.80.20.6-0.40.40.50.50.41.40.4
Bone: connectivity density0.50.81.31.2-0.90.50.9-0.80.80.80.90.81.20.7
Bone: cortical apparent density1.21.62.91.7-1.20.91.4-1.21.11.21.31.21.51.2
Bone: cortical area0.71.11.4-0.91.1-1.2-1.11.1-1.1-1.1-1.1-1.2-0.5-1.1
Bone: cortical porosity7.48.010.8-3.32.9-2.3-2.92.7-2.6-2.7-2.8-2.7-3.2-2.7
Bone: cortical porosity8.79.412.7-3.63.2-2.6-3.23.0-2.8-3.0-3.0-3.0-3.4-3.0
Bone: cortical thickness0.30.40.8-0.40.8-0.9-0.60.7-0.7-0.7-0.7-0.7-0.1-0.7
Bone: cortical thickness1.72.03.0-1.01.3-1.7-1.31.4-1.5-1.4-1.4-1.3-1.5-1.5
Bone: cortical tissue density1.42.03.31.8-1.31.01.5-1.31.31.41.41.41.61.3
Condit. Reinf. active minus inactive responses1.11.21.6-1.11.2-1.0-1.11.1-1.1-1.1-1.0-1.0-1.3-1.0
Condit. Reinf. active-inactive response ratio0.10.10.4-0.40.30.0-0.20.2-0.1-0.2-0.1-0.1-0.6-0.1
Condit. Reinf. active responses2.02.43.0-1.41.7-1.7-1.61.6-1.6-1.6-1.5-1.5-1.4-1.5
Condit. Reinf. inactive responses1.61.93.3-0.91.3-1.8-1.31.5-1.6-1.5-1.4-1.5-0.8-1.4
Incentive salience index mean1.51.92.2-1.21.4-1.5-1.41.4-1.4-1.4-1.3-1.3-1.3-1.3
Condit. Reinf. lever presses1.21.73.0-0.81.3-1.7-1.21.4-1.5-1.4-1.4-1.4-0.8-1.3
Condit. Reinf. active minus inactive responses7.910.210.7-3.13.1-3.3-3.23.3-3.3-3.3-3.3-3.2-3.0-3.2
Condit. Reinf. active-inactive response ratio6.37.37.8-2.82.7-2.7-2.82.7-2.7-2.7-2.7-2.7-2.6-2.6
Condit. Reinf. active responses5.57.78.3-2.72.5-2.9-2.82.8-2.9-2.8-2.9-2.9-2.6-2.8
Condit. Reinf. inactive responses0.30.40.6-0.50.4-0.7-0.60.7-0.7-0.7-0.8-0.7-0.7-0.7
Condit. Reinf. lever presses1.21.71.9-1.31.2-1.4-1.31.4-1.4-1.4-1.4-1.4-1.0-1.3
Condit. Reinf. lever reinforcers received5.67.98.3-2.82.6-2.8-2.92.9-2.9-2.9-2.9-2.9-2.6-2.8
Conditioned reinforcement - actives0.91.63.51.4-1.91.11.3-1.21.21.21.11.01.20.8
Conditioned reinforcement - inactives1.82.73.8-1.30.9-1.8-1.51.6-1.7-1.6-1.9-2.0-1.5-1.9
Conditioned locomotion4.35.510.53.2-3.21.62.6-2.32.12.31.91.72.61.7
Patch foraging indifference point 0 sec0.91.72.31.0-1.21.51.3-1.41.41.31.41.31.11.3
Patch foraging indifference point AUC1.62.34.7-0.71.4-2.2-1.41.6-1.8-1.6-1.6-1.6-0.5-1.6
Delay disc. indifference point, 0s delay1.41.62.21.5-1.31.21.3-1.21.21.21.21.21.21.2
Delay disc. indifference point, 16s delay0.10.10.1-0.10.2-0.3-0.30.3-0.4-0.3-0.2-0.2-0.2-0.2
Delay disc. indifference point, 2s delay1.71.82.21.4-1.51.31.4-1.41.31.41.31.21.51.3
Delay disc. indifference point, 24s delay0.20.20.40.4-0.50.40.4-0.40.40.40.40.40.60.4
Delay disc. indifference point, 4s delay1.21.31.81.4-1.21.01.2-1.11.01.11.00.91.31.0
Delay disc. indifference point, 8s delay0.00.00.0-0.10.0-0.1-0.10.1-0.2-0.1-0.2-0.2-0.1-0.2
Indifference point function ln k2.34.16.41.4-2.02.51.9-2.12.22.12.12.01.52.1
Indifference point function log k2.34.16.41.4-2.02.51.9-2.12.22.12.12.01.52.1
Patch foraging total patch changes 0 sec0.81.52.40.9-1.21.51.2-1.31.41.31.31.31.01.2
Patch foraging total patch changes 12 sec0.30.41.1-0.10.6-1.1-0.50.7-0.8-0.7-0.6-0.60.2-0.8
Patch foraging total patch changes 18 sec0.20.30.60.8-0.50.30.6-0.50.50.50.60.60.60.4
Patch foraging total patch changes 24 sec0.10.30.7-0.10.1-0.8-0.40.5-0.6-0.5-0.5-0.5-0.4-0.6
Patch foraging total patch changes 6 sec0.71.12.91.2-1.00.81.0-0.90.90.90.90.81.70.9
Patch foraging time to switch 0 sec0.00.00.0-0.20.10.1-0.10.00.0-0.00.10.10.00.1
Patch foraging water rate 0 sec0.00.00.10.3-0.30.20.2-0.20.20.20.20.3-0.00.1
Patch foraging water rate 12 sec0.51.01.70.6-0.91.30.9-1.11.11.01.21.30.21.1
Patch foraging water rate 18 sec0.10.20.8-0.90.60.1-0.40.2-0.1-0.3-0.2-0.2-0.6-0.2
Patch foraging water rate 24 sec0.40.51.6-0.2-0.41.30.5-0.80.90.70.70.8-0.50.7
Patch foraging water rate 6 sec1.92.83.91.5-1.41.81.6-1.71.71.71.92.01.41.6
Seeking ratio, delayed vs. immediate footshock0.81.02.1-0.60.8-1.4-1.01.2-1.2-1.1-0.7-0.7-0.3-1.2
Distance traveled before self-admin3.54.66.3-1.62.0-2.5-2.12.2-2.3-2.2-2.2-2.3-1.6-2.3
Distance traveled after self-admin0.10.10.40.10.1-0.7-0.20.4-0.4-0.4-0.3-0.30.1-0.5
Extensor digitorum longus weight1.87.09.83.1-2.72.32.8-2.62.52.62.62.62.72.5
Bone: elastic displacement0.10.10.10.3-0.20.30.3-0.20.20.20.20.20.40.3
Bone: elastic work0.30.30.6-0.80.5-0.4-0.70.6-0.6-0.6-0.6-0.7-0.2-0.6
Bone: endosteal estimation1.63.64.4-1.91.3-1.9-1.91.9-2.0-2.0-2.0-2.1-1.5-2.0
Bone: endosteal perimeter0.30.61.3-1.10.7-0.4-0.80.7-0.7-0.7-0.8-0.8-0.8-0.6
Epididymis fat weight0.20.60.80.7-0.90.80.8-0.80.80.80.70.60.70.7
Delta time in closed arm before/after self-admin1.00.91.61.0-1.30.91.0-0.90.90.90.80.81.00.9
Delta time in open arm before/after self-admin5.85.86.3-2.32.4-2.4-2.42.4-2.4-2.4-2.5-2.5-2.3-2.4
Diff in mean of infusions in LGA sessions0.40.50.60.6-0.50.70.7-0.70.70.70.70.70.60.7
Delay discount exponential model param0.10.10.2-0.40.4-0.2-0.30.3-0.2-0.3-0.2-0.2-0.4-0.2
Extinction: sum of active levers before priming0.00.00.20.4-0.2-0.20.1-0.0-0.00.0-0.1-0.20.4-0.1
Active lever presses in extinction session 60.90.91.1-0.91.1-1.0-0.91.0-0.9-0.9-0.9-0.8-0.9-1.0
Bone: final force1.52.42.9-1.71.4-1.4-1.61.5-1.5-1.5-1.6-1.6-1.5-1.7
Bone: final moment1.01.62.2-1.51.2-1.0-1.31.2-1.1-1.2-1.3-1.2-1.4-1.3
Food consumed during 24 hour testing period0.70.91.4-0.81.0-1.2-1.01.0-1.1-1.0-1.0-1.0-0.5-0.9
Glucose0.61.01.21.1-0.90.91.0-1.01.01.01.01.11.11.0
Heart weight0.10.20.8-0.90.20.3-0.40.2-0.1-0.2-0.3-0.3-0.9-0.2
Delay discount hyperbolic model param0.20.20.3-0.50.5-0.4-0.40.4-0.3-0.4-0.3-0.3-0.5-0.3
Intermittent access intake day 1-15 change0.20.50.50.7-0.70.70.7-0.70.70.70.70.70.40.7
Intermittent access intake escalation0.20.50.80.4-0.50.90.7-0.80.80.80.70.80.10.7
Intermittent access intake escalation 20.20.30.40.6-0.30.50.6-0.60.60.60.50.60.40.6
Intermitt. access day 1 inactive lever presses0.10.51.30.1-0.71.10.5-0.70.80.70.80.80.30.8
Intermitt. access day 15 inactive lever presses0.10.10.4-0.5-0.30.0-0.30.2-0.1-0.2-0.4-0.4-0.7-0.3
Intermitt. access escalation Index0.20.31.61.00.1-0.20.5-0.30.20.30.30.31.30.4
Intermittent access day 1 total infusions0.10.20.6-0.1-0.2-0.7-0.40.5-0.5-0.5-0.4-0.4-0.1-0.8
Intermittent access day 15 total infusions0.50.71.81.0-1.30.70.9-0.80.80.80.90.90.80.5
Intermittent access terminal intake (last 3 days)1.41.83.21.4-1.81.21.3-1.31.31.31.41.41.21.0
Intermittent access total infusions0.30.31.20.9-1.10.10.5-0.40.30.40.50.40.70.0
Intermittent access day 1 locomotion0.10.10.30.6-0.6-0.30.2-0.0-0.00.0-0.1-0.20.2-0.3
Intermittent access day 15 total locomotion0.61.13.11.4-1.80.61.0-0.90.80.90.90.91.10.5
Intermittent access total locomotion2.12.65.82.3-2.40.91.7-1.41.31.41.31.21.70.9
Intermittent access standard deviation0.00.10.3-0.3-0.20.0-0.20.1-0.1-0.1-0.1-0.1-0.6-0.2
Left kidney weight0.52.34.02.0-1.31.11.6-1.41.41.51.41.42.01.5
Right kidney weight0.73.34.12.0-1.71.51.9-1.81.71.81.81.82.01.8
Cocaine induced anxiety0.30.40.80.4-0.20.90.6-0.70.80.70.50.5-0.20.9
Post-drug Anxiety1.21.32.00.9-1.21.41.1-1.21.21.20.91.00.51.4
Baseline Anxiety0.30.41.00.4-1.00.70.5-0.60.60.50.50.50.60.5
Tail length3.312.714.3-3.83.6-3.4-3.73.6-3.5-3.6-3.4-3.4-3.8-3.5
Length with tail3.917.018.1-4.14.0-4.1-4.14.1-4.1-4.1-4.3-4.2-4.1-4.1
Length without tail0.82.53.6-1.51.3-1.6-1.51.5-1.5-1.5-1.8-1.9-1.5-1.6
Times rat made contact with spout0.91.01.5-1.01.0-1.0-1.01.0-1.0-1.0-1.0-0.9-1.2-1.0
Lifetime Intake0.60.71.91.0-1.40.60.8-0.80.70.70.80.80.80.4
Liver weight, left3.25.27.5-1.81.9-2.7-2.22.4-2.5-2.4-2.4-2.4-1.8-2.5
Liver weight, right0.20.30.70.8-0.70.20.5-0.40.40.50.30.30.80.3
Locomotor activity0.10.10.3-0.2-0.10.50.1-0.30.40.30.20.2-0.40.2
Locomotor testing distance0.20.41.0-0.0-0.31.00.4-0.60.80.60.60.7-0.40.6
Locomotor testing rearing0.10.20.5-0.2-0.10.70.3-0.40.60.40.40.5-0.50.4
Locomotion in novel chamber0.50.72.01.4-1.00.10.9-0.60.50.60.60.51.40.5
Locomotion in novel chamber post-restriction0.00.00.10.30.1-0.40.00.1-0.2-0.1-0.1-0.00.1-0.1
Fecal boli incidents, locomotor time 11.01.51.8-1.31.3-1.2-1.21.2-1.2-1.2-1.1-1.1-1.4-1.2
Change in fecal boli incidents, locomotor task0.00.00.1-0.20.1-0.1-0.10.1-0.1-0.1-0.2-0.3-0.2-0.1
Time >=10cm from walls, locomotor time 12.72.83.4-1.61.6-1.6-1.61.6-1.7-1.6-1.8-1.8-1.8-1.6
Bouts of movement, locomotor time 12.12.44.9-1.41.4-1.4-1.41.5-1.5-1.4-1.6-1.4-2.2-1.5
Total resting periods, locomotor time 11.51.74.0-1.21.2-1.2-1.21.2-1.2-1.2-1.4-1.2-2.0-1.3
Rest time, locomotor task time 12.63.23.3-1.71.8-1.8-1.81.8-1.8-1.8-1.8-1.8-1.7-1.8
Distance moved, locomotor task time 10.40.71.31.0-0.90.70.8-0.80.70.80.60.61.10.8
Vertical activity count, locomotor time 10.51.32.01.2-1.21.11.1-1.11.11.11.00.91.41.1
Time >=10cm from walls, locomotor time 20.60.91.4-1.00.9-0.9-0.90.9-0.9-0.9-0.9-0.8-1.2-0.9
Bouts of movement, locomotor time 20.40.60.90.7-0.80.80.8-0.80.80.80.91.00.40.8
Total resting periods, locomotor time 20.10.10.20.2-0.30.30.3-0.30.30.30.40.5-0.10.3
Rest time, locomotor task time 21.62.02.6-1.51.4-1.4-1.51.4-1.4-1.4-1.6-1.6-1.1-1.4
Distance moved, locomotor task time 20.91.01.31.2-1.00.91.0-1.00.91.01.01.01.11.0
Vertical activity count, locomotor time 23.34.65.12.3-2.22.12.2-2.12.12.12.12.12.22.1
Light reinforcement 11.33.27.81.8-1.61.51.7-1.61.61.71.81.62.81.7
Light reinforcement 20.50.81.1-1.00.8-0.8-0.90.9-0.9-0.9-0.9-1.0-0.5-0.9
Bone: marrow area1.53.34.1-1.81.2-1.8-1.91.9-1.9-1.9-2.0-2.0-1.5-1.9
Bone: maximum diameter0.81.51.8-1.31.2-1.2-1.31.3-1.3-1.3-1.3-1.3-0.7-1.2
Bone: maximum force0.91.62.0-1.41.1-1.2-1.31.3-1.2-1.3-1.3-1.3-1.2-1.4
Bone: maximum moment0.40.71.1-1.10.6-0.6-0.90.8-0.7-0.8-0.9-0.9-1.0-0.9
Mean time between licks in bursts0.41.01.21.0-1.10.91.0-1.01.01.01.01.01.10.9
Mean num. licks in bursts0.40.60.9-0.60.6-0.9-0.80.8-0.9-0.8-0.9-0.9-0.6-0.9
Cd content in liver1.21.33.00.5-0.81.71.1-1.31.41.21.11.00.51.4
Co content in liver0.10.10.4-0.50.20.60.0-0.20.20.20.10.0-0.40.3
Cu content in liver0.10.20.30.3-0.50.50.4-0.40.40.40.40.40.30.4
Fe content in liver0.20.20.8-0.90.40.1-0.40.3-0.2-0.3-0.3-0.2-0.9-0.1
K content in liver0.10.10.50.7-0.3-0.50.20.0-0.1-0.00.00.00.6-0.0
Mg content in liver0.20.20.70.8-0.9-0.00.4-0.30.20.30.30.30.60.2
Mn content in liver1.31.41.81.3-1.21.11.3-1.21.21.21.21.30.91.1
Na content in liver1.21.33.4-0.10.5-1.9-0.91.2-1.4-1.2-1.3-1.2-0.4-1.3
Rb content in liver0.20.20.30.5-0.60.40.5-0.40.40.40.50.50.50.4
Se content in liver0.40.51.00.1-1.01.00.5-0.70.70.60.60.7-0.10.6
Sr content in liver1.10.91.7-0.91.3-1.0-0.91.0-1.0-1.0-1.0-1.0-0.9-0.8
Zn content in liver0.20.20.50.6-0.70.30.5-0.40.40.40.40.40.40.4
Bone: minimum diameter1.42.53.2-1.81.6-1.4-1.71.6-1.6-1.6-1.6-1.7-1.4-1.4
Time in familiar zone, hab. session 12.12.12.91.4-1.61.51.4-1.51.51.41.31.21.71.3
Time in novel zone, hab. session 16.26.27.8-2.52.8-2.4-2.62.5-2.5-2.5-2.3-2.2-2.6-2.3
Total zone transitions, hab. session 10.60.81.1-1.01.1-0.9-1.00.9-0.9-0.9-0.8-0.7-0.7-0.8
Total locomotion distance, hab. session 11.92.63.9-1.72.0-1.6-1.71.7-1.6-1.7-1.5-1.4-1.4-1.5
Locomotion velocity, hab. session 11.42.03.0-1.51.7-1.4-1.51.5-1.4-1.5-1.2-1.2-1.1-1.3
Time in familiar zone, hab. session 20.10.10.40.7-0.50.10.4-0.30.20.30.20.20.70.2
Time in novel zone, hab. session 20.10.10.2-0.50.20.4-0.1-0.10.20.00.10.2-0.40.1
Total zone transitions, hab. session 20.00.00.2-0.50.30.2-0.20.00.1-0.00.10.2-0.20.0
Total locomotion distance, hab. session 20.00.10.3-0.50.40.2-0.20.10.0-0.10.10.1-0.20.1
Locomotion velocity, hab. session 20.00.00.2-0.50.40.1-0.20.10.0-0.10.10.1-0.10.1
Novel to familiar place preference ratio1.31.52.0-1.21.4-1.2-1.21.2-1.2-1.2-1.2-1.2-1.0-1.2
Novelty place preference1.82.02.4-1.21.5-1.5-1.41.4-1.4-1.4-1.4-1.4-1.1-1.5
Time in novel zone, NPP test2.12.22.6-1.31.6-1.6-1.51.5-1.5-1.5-1.5-1.5-1.2-1.5
Total zone transitions, NPP test0.20.30.4-0.60.6-0.6-0.60.6-0.6-0.6-0.4-0.4-0.6-0.4
Total locomotion distance, NPP test0.50.70.9-0.90.9-0.8-0.90.9-0.8-0.9-0.7-0.7-0.8-0.7
Locomotion velocity, NPP test0.20.30.4-0.60.6-0.5-0.60.6-0.6-0.6-0.4-0.4-0.4-0.4
Intraocular pressure3.55.16.12.0-2.22.52.2-2.32.32.32.32.22.22.4
Delta distance traveled before/after self-admin2.02.22.61.4-1.51.51.4-1.51.51.51.51.61.41.5
Delta ambulatory time before/after self-admin2.12.53.01.5-1.61.61.6-1.61.61.61.71.71.51.6
Parametrial fat weight0.10.30.8-0.2-0.20.90.3-0.50.60.50.50.6-0.20.6
Pavlov. Cond. lever latency0.20.20.40.2-0.30.60.4-0.50.50.50.50.40.40.5
Pavlov. Cond. magazine entry latency0.91.11.6-1.11.1-1.0-1.11.1-1.0-1.1-1.0-1.0-1.3-1.0
Pavlov. Cond. change in total contacts0.00.00.10.3-0.1-0.10.1-0.0-0.00.10.00.10.00.1
Pavlov. Cond. index score0.60.81.2-0.70.8-1.1-0.91.0-1.0-0.9-0.9-0.9-0.9-0.9
Pavlov. Cond. latency score0.60.71.1-0.60.7-1.0-0.80.9-0.9-0.9-0.9-0.8-0.9-0.8
Pavlov. Cond. lever contacts0.20.20.6-0.10.3-0.7-0.40.5-0.6-0.5-0.5-0.5-0.4-0.5
Pavlov. Cond. magazine entry number0.20.20.40.5-0.50.40.5-0.50.50.50.40.40.70.4
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.1-0.1-0.0-0.00.0-0.0-0.0-0.0-0.00.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.70.81.2-0.70.8-1.1-0.91.0-1.0-0.9-0.9-0.9-0.9-0.9
Pavlov. Cond. response bias0.60.71.0-0.80.9-0.9-0.80.9-0.9-0.9-0.8-0.8-1.0-0.8
Pavlov. Cond. lever latency1.21.72.21.5-1.31.21.4-1.31.21.31.31.21.31.2
Pavlov. Cond. magazine entry latency0.30.30.4-0.50.5-0.6-0.50.6-0.6-0.6-0.6-0.6-0.5-0.6
Pavlov. Cond. change in total contacts1.42.22.4-1.61.5-1.4-1.51.5-1.5-1.5-1.5-1.5-1.3-1.4
Pavlov. Cond. index score1.92.52.6-1.61.6-1.6-1.61.6-1.6-1.6-1.6-1.6-1.5-1.6
Pavlov. Cond. latency score1.62.22.3-1.51.4-1.5-1.51.5-1.5-1.5-1.5-1.5-1.5-1.5
Pavlov. Cond. lever contacts2.02.83.4-1.81.7-1.6-1.81.7-1.7-1.7-1.6-1.7-1.5-1.6
Pavlov. Cond. magazine entry number0.91.11.50.7-1.01.21.0-1.11.11.11.11.10.91.1
Pavlov. Cond. intertrial magazine entries1.82.73.11.7-1.71.51.7-1.61.61.61.71.71.71.6
Pavlov. Cond. lever-magazine prob. diff.1.72.32.4-1.51.5-1.5-1.51.5-1.5-1.5-1.5-1.5-1.4-1.5
Pavlov. Cond. response bias2.22.93.2-1.81.8-1.7-1.81.7-1.7-1.7-1.7-1.7-1.5-1.7
Time in closed arm before self-admin1.41.82.6-1.41.3-1.1-1.31.2-1.2-1.3-1.5-1.6-1.4-1.3
Time in closed arm after self-admin0.00.00.1-0.30.10.3-0.1-0.10.10.00.00.0-0.30.1
Time in open arm before self-admin2.62.83.31.8-1.71.51.7-1.61.61.61.81.81.81.7
Time in open arm after self-admin2.62.94.4-1.31.5-2.1-1.71.8-1.9-1.8-1.7-1.7-1.3-1.8
Bone: periosteal estimation1.63.34.0-1.91.5-1.8-1.91.9-1.9-1.9-1.9-2.0-1.4-1.9
Bone: periosteal perimeter1.01.72.2-1.51.3-1.2-1.41.3-1.3-1.3-1.4-1.4-1.1-1.2
Bone: post-yield work0.10.10.3-0.1-0.30.50.2-0.30.40.30.20.20.20.3
Progressive ratio test 1 active lever presses0.10.10.40.5-0.7-0.10.2-0.10.10.10.10.00.4-0.3
Progressive ratio test 1 breakpoint0.10.10.30.4-0.5-0.30.10.0-0.1-0.0-0.0-0.10.3-0.4
Progressive ratio test 1 inactive lever presses1.41.93.71.3-1.91.31.4-1.41.31.31.31.21.61.0
Progressive ratio test 2 active lever presses0.10.10.40.4-0.5-0.50.00.2-0.2-0.1-0.2-0.30.2-0.6
Progressive ratio test 2 breakpoint0.10.10.40.2-0.4-0.5-0.10.2-0.2-0.2-0.3-0.30.0-0.7
Progressive ratio test 2 inactive lever presses0.20.41.61.2-1.3-0.30.5-0.20.10.2-0.0-0.10.8-0.1
Incentive Sensitization - Responses0.30.41.10.10.0-1.1-0.40.6-0.7-0.6-0.7-0.8-0.1-0.9
Incentive Sensitization - Breakpoint0.20.30.80.1-0.0-0.9-0.30.5-0.5-0.5-0.6-0.7-0.1-0.8
Sum of active levers in priming session hrs 5-62.32.13.5-1.01.2-1.9-1.41.6-1.6-1.5-1.5-1.5-1.0-1.6
Progressive ratio0.00.00.2-0.30.4-0.1-0.20.2-0.1-0.20.0-0.00.1-0.1
Food seeking constrained by brief footshock1.51.93.51.7-1.30.91.4-1.31.21.31.31.31.91.3
Seeking ratio, punishment vs. effort0.50.71.41.2-1.00.60.9-0.80.80.80.60.60.90.7
Retroperitoneal fat weight0.83.44.41.7-2.12.01.9-1.91.91.91.71.71.71.9
Reaction time number correct0.40.81.30.6-0.71.20.9-1.01.11.00.80.80.60.9
Reaction time mean minus median0.00.10.40.30.1-0.6-0.10.3-0.3-0.2-0.2-0.20.1-0.3
Reaction time mean minus median AUC0.10.30.8-0.10.6-0.9-0.50.6-0.7-0.6-0.4-0.4-0.3-0.5
Reaction time num false alarms3.75.25.62.3-2.22.32.3-2.32.32.32.32.42.02.3
Reaction time num false alarms AUC3.04.75.22.1-2.12.22.2-2.32.32.22.22.31.72.2
Reaction time trials correct on left0.40.81.30.6-0.71.20.9-1.01.11.00.80.80.60.9
Reaction time trials on left0.40.81.40.6-0.71.20.9-1.01.11.00.80.80.60.9
Reaction time mean3.45.46.3-2.12.2-2.5-2.32.4-2.4-2.4-2.3-2.3-2.2-2.4
Reaction time mean AUC2.64.14.9-1.81.9-2.2-2.02.1-2.1-2.1-2.0-2.0-1.8-2.0
Median of all reaction times5.47.68.1-2.72.6-2.8-2.82.8-2.8-2.8-2.8-2.8-2.7-2.8
Reaction time omissions0.20.20.70.1-0.90.80.4-0.50.50.50.30.3-0.00.3
Reaction time false alarm rate1.52.12.61.4-1.51.51.5-1.51.51.51.51.61.01.5
Reaction time premature initiation rate0.20.30.4-0.50.3-0.5-0.50.5-0.5-0.5-0.6-0.7-0.0-0.6
Reaction time premature initiations0.00.00.1-0.1-0.10.20.0-0.10.10.1-0.1-0.10.30.0
Std. dev. reaction times0.51.01.6-0.70.9-1.3-1.01.1-1.1-1.1-0.9-0.9-0.9-1.0
Reaction time trials completed0.40.81.40.6-0.71.20.9-1.01.11.00.80.80.60.9
Reaction time trials AUC0.30.50.90.5-0.61.00.7-0.80.90.80.70.70.60.8
Run reversals in cocaine runway, females0.60.61.20.4-0.51.10.7-0.80.90.80.60.70.41.0
Run reversals in cocaine runway, males0.20.20.6-0.80.6-0.2-0.50.3-0.3-0.4-0.2-0.2-0.7-0.3
Latency to leave start box in cocaine runway3.03.44.51.8-1.71.71.8-1.81.71.82.12.11.81.8
Latency to leave start box in cocaine runway, F2.73.13.71.5-1.61.91.7-1.81.81.81.91.91.51.8
Latency to leave start box in cocaine runway, M0.70.71.21.0-0.70.40.8-0.70.60.71.01.11.10.7
Std. dev. time between licks in bursts2.73.64.02.0-1.91.81.9-1.91.91.92.02.01.81.8
Total sessions with >9 infusions0.00.10.30.1-0.50.20.1-0.20.10.10.30.30.1-0.1
Short access day 1 total inactive lever presses0.40.62.01.1-1.40.40.8-0.70.60.70.30.30.60.6
Short access day 10 total inactive lever presses0.10.10.7-0.80.20.4-0.30.1-0.0-0.1-0.00.1-0.70.2
Short access day 1 total infusions0.30.51.50.4-1.20.80.6-0.70.70.60.70.60.30.4
Short access day 10 total infusions0.20.30.60.7-0.80.20.5-0.40.40.40.50.50.80.2
Short access total infusions1.01.32.20.9-1.51.41.1-1.21.31.21.11.10.81.0
Short access day 1 locomotion0.30.40.7-0.70.1-0.6-0.60.6-0.6-0.6-0.7-0.7-0.6-0.8
Short access day 10 total locomotion0.20.40.50.7-0.70.70.7-0.70.70.70.30.3-0.20.5
Short access total locomotion0.70.81.51.2-1.20.81.1-1.00.91.00.60.50.50.7
One hour access (0.3 mA shock)0.10.20.50.7-0.7-0.40.3-0.1-0.00.10.10.10.6-0.3
Compulsive drug intake0.30.30.9-0.00.11.00.4-0.60.70.60.40.50.00.9
One hour access (shock baseline)0.10.21.00.6-1.00.10.4-0.30.20.30.50.50.4-0.1
Social response proportion0.30.40.6-0.50.6-0.8-0.60.7-0.7-0.7-0.6-0.7-0.3-0.5
Social responses0.70.92.0-0.71.4-1.2-0.91.0-1.0-1.0-0.9-0.9-0.5-0.8
Social time0.30.40.5-0.50.6-0.7-0.60.7-0.7-0.6-0.7-0.7-0.6-0.6
Soleus weight0.00.10.60.7-0.2-0.50.20.0-0.20.0-0.1-0.10.4-0.1
Bone: stiffness0.81.21.6-1.10.9-1.2-1.11.1-1.1-1.1-1.2-1.1-1.0-1.3
Tibialis anterior weight0.31.12.21.5-1.00.61.1-0.90.91.00.90.91.40.9
Time to tail flick, vehicle, before self-admin0.20.20.4-0.30.3-0.6-0.40.5-0.5-0.5-0.4-0.5-0.3-0.6
Time to tail flick, vehicle, after self-admin0.40.51.5-1.20.9-0.1-0.80.5-0.4-0.6-0.4-0.2-1.2-0.3
Time to tail flick, test, before self-admin0.20.20.6-0.80.40.2-0.40.2-0.2-0.2-0.3-0.2-0.8-0.1
Time to tail flick, test, after self-admin2.42.53.71.9-1.91.31.7-1.51.51.51.31.21.91.4
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.2-0.00.80.2-0.40.50.40.50.7-0.20.6
Delta time to tail flick, test, before/after SA1.61.63.71.9-1.50.61.4-1.11.01.10.90.81.90.9
Tibia length1.43.84.7-2.11.9-1.9-2.02.0-2.0-2.0-2.1-2.2-1.4-1.8
Ambulatory time before self-admin2.13.15.0-1.11.5-2.2-1.61.9-1.9-1.8-1.8-1.9-1.1-2.0
Ambulatory time after self-admin0.20.31.01.0-0.7-0.10.5-0.30.30.40.30.21.00.2
Bone: tissue strength0.70.71.70.3-0.81.30.8-0.91.00.90.80.70.50.9
Total heroin consumption0.80.91.8-1.01.3-0.8-1.00.9-0.9-0.9-0.8-0.7-1.0-0.8
Bone: trabecular number0.10.20.30.6-0.40.30.5-0.40.40.40.50.50.50.4
Bone: trabecular spacing0.40.50.9-0.90.6-0.4-0.70.6-0.6-0.6-0.8-0.8-0.9-0.6
Bone: trabecular thickness0.50.70.9-0.70.9-0.9-0.80.8-0.8-0.8-0.8-0.8-0.5-0.9
Bone: trabecular tissue density0.91.42.4-1.31.3-0.9-1.21.1-1.1-1.1-1.1-1.1-1.5-1.0
Water consumed over 24 hours0.00.00.10.20.2-0.30.00.1-0.1-0.0-0.00.00.2-0.0
Number of responses in last shaping day0.40.40.9-0.90.1-0.4-0.70.6-0.6-0.7-0.5-0.4-1.0-0.7