Hub : Genes

Mettl21a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	Mettl21a	0.02	0.02	9.9e-03	0.01	0	0	0.01	1.8e-02	1.7e-01	1.8e-01	3.8e-02
2	Liver	intron excision ratio	chr9_65985095_65986197	0.04	0.04	4.9e-04	0.03	0.03	0.03	0.03	5.7e-04	6.3e-04	4.6e-04	6.0e-04
3	LHb	gene expression	Mettl21a	0.22	0.14	3.2e-05	0.1	0.15	0.1	0.14	3.0e-03	2.2e-04	1.8e-03	3.6e-04
4	Brain	mRNA stability	Mettl21a	0.04	0.04	2.2e-04	0.03	0.04	0.04	0.04	9.0e-04	1.3e-04	3.0e-04	1.5e-04
5	NAcc	intron excision ratio	chr9_65986364_65987108	0.03	0.03	2.8e-03	0.02	0.02	0.02	0.02	4.0e-03	4.9e-03	1.7e-03	2.4e-03
6	Liver	gene expression	Mettl21a	0.04	0.04	3.9e-04	0.02	0.02	0.01	0.02	2.7e-03	2.7e-03	1.2e-02	4.6e-03
7	NAcc	intron excision ratio	chr9_65986364_65986906	0.04	0.04	2.8e-03	0.02	0.01	0.01	0.01	2.9e-03	1.9e-02	7.4e-03	9.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.1	0.2	0.3	0.5	0.4	-0.4	-0.4	-0.4	0.4	0.4
Area under the delay curve	0.0	0.0	0.1	-0.3	-0.1	0.2	0.2	0.1	-0.1	-0.1
BMI with tail	8.2	26.5	28.0	-5.1	-5.3	5.2	5.2	5.1	-5.0	-5.0
BMI without tail	3.9	8.0	9.8	-3.1	-2.8	2.7	2.7	2.8	-2.8	-2.8
Body weight	0.4	1.6	1.9	-1.0	-1.4	1.3	1.2	1.4	-1.3	-1.3
Weight adjusted by age	0.4	0.4	0.6	0.3	0.6	-0.6	-0.6	-0.7	0.8	0.8
Bone surface	0.5	0.9	1.3	1.1	0.9	-0.9	-0.9	-0.9	0.9	0.9
Bone volume	0.9	1.6	1.9	1.4	1.2	-1.3	-1.3	-1.2	1.2	1.2
Breakpoint value in progressive ratio session	1.3	1.4	1.7	1.2	1.2	-1.3	-1.3	-1.1	1.1	1.1
Number of licking bursts	0.3	0.3	0.4	-0.4	-0.6	0.5	0.5	0.7	-0.7	-0.7
Context. condit. distance diff. score	1.5	1.8	2.0	-1.4	-1.3	1.2	1.3	1.4	-1.4	-1.4
Locomotion velocity, session 1	1.5	1.7	1.8	1.3	1.3	-1.3	-1.3	-1.3	1.3	1.3
Locomotion distance, session 1	0.2	0.3	0.4	0.6	0.6	-0.5	-0.5	-0.6	0.5	0.5
Locomotion velocity, session 2	0.2	0.3	0.3	0.4	0.5	-0.4	-0.5	-0.6	0.6	0.6
Locomotion distance, session 2	0.0	0.0	0.0	0.1	0.0	0.0	0.0	-0.1	0.1	0.1
Locomotion velocity, session 3	0.6	0.7	0.8	-0.8	-0.8	0.8	0.8	0.9	-0.9	-0.9
Locomotion distance, session 3	1.4	1.6	1.7	1.2	1.3	-1.3	-1.3	-1.2	1.2	1.2
Stereotopy head waving bouts, day 3	2.0	2.4	2.7	-1.6	-1.5	1.6	1.6	1.5	-1.5	-1.5
Stereotopy head waving duration, day 3	2.3	2.8	3.0	-1.7	-1.7	1.7	1.7	1.6	-1.6	-1.6
Locomotion velocity, session 7	0.0	0.0	0.0	-0.0	-0.2	0.2	0.2	0.2	-0.2	-0.2
Locomotion distance, session 7	0.4	0.5	0.8	0.9	0.7	-0.7	-0.7	-0.7	0.7	0.7
Stereotopy head waving bouts, day 7	0.5	0.6	0.8	-0.9	-0.7	0.7	0.8	0.7	-0.7	-0.7
Stereotopy head waving duration, day 7	2.3	2.8	3.1	-1.8	-1.6	1.7	1.7	1.6	-1.6	-1.6
Locomotion velocity, session 8	0.1	0.1	0.2	-0.4	-0.3	0.4	0.4	0.3	-0.3	-0.3
Locomotion distance, session 8	0.3	0.4	0.5	-0.7	-0.6	0.6	0.6	0.7	-0.7	-0.7
Degree of sensitization distance	0.3	0.3	0.4	-0.5	-0.6	0.6	0.6	0.5	-0.5	-0.5
Degree of sensitization stereotypy	0.8	0.9	1.2	-1.1	-0.9	0.9	1.0	0.9	-0.9	-0.9
Conditioned locomotion	1.4	1.7	2.0	1.4	1.2	-1.3	-1.3	-1.3	1.3	1.3
Cocaine response after cond. corrected	1.4	1.6	1.7	1.2	1.3	-1.2	-1.2	-1.3	1.3	1.3
Cocaine response after cond. not corrected	1.5	1.7	1.9	1.3	1.4	-1.3	-1.3	-1.3	1.3	1.3
Cocaine response before conditioning	0.1	0.1	0.1	-0.3	-0.2	0.2	0.3	0.3	-0.3	-0.3
Saline control response	0.5	0.7	0.8	-0.8	-0.9	0.9	0.8	0.8	-0.8	-0.8
Bone: connectivity density	0.3	0.4	0.5	-0.5	-0.7	0.7	0.7	0.7	-0.7	-0.7
Bone: cortical apparent density	1.9	2.6	3.0	-1.7	-1.6	1.7	1.6	1.5	-1.5	-1.5
Bone: cortical area	0.8	1.3	1.7	1.3	1.1	-1.2	-1.2	-1.1	1.1	1.1
Bone: cortical porosity	6.8	7.4	8.1	2.8	2.7	-2.8	-2.8	-2.6	2.6	2.6
Bone: cortical porosity	8.0	8.7	9.5	3.1	2.9	-3.1	-3.0	-2.8	2.8	2.8
Bone: cortical thickness	0.2	0.3	0.6	0.8	0.5	-0.6	-0.6	-0.5	0.5	0.5
Bone: cortical thickness	2.6	3.1	3.6	1.9	1.8	-1.7	-1.7	-1.7	1.7	1.7
Bone: cortical tissue density	2.3	3.1	3.5	-1.9	-1.8	1.8	1.8	1.7	-1.7	-1.7
Condit. Reinf. active minus inactive responses	1.0	1.1	1.2	1.0	1.0	-1.1	-1.1	-1.0	1.0	1.0
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.1	0.1	0.1
Condit. Reinf. active responses	2.0	2.5	2.6	1.6	1.6	-1.6	-1.6	-1.6	1.6	1.6
Condit. Reinf. inactive responses	1.8	2.2	2.4	1.5	1.5	-1.4	-1.5	-1.5	1.5	1.5
Incentive salience index mean	1.6	1.9	1.9	1.4	1.4	-1.4	-1.4	-1.4	1.4	1.4
Condit. Reinf. lever presses	1.7	2.3	2.5	1.5	1.5	-1.4	-1.5	-1.6	1.6	1.6
Condit. Reinf. active minus inactive responses	9.0	11.1	11.4	3.2	3.4	-3.3	-3.3	-3.4	3.4	3.4
Condit. Reinf. active-inactive response ratio	7.3	7.7	7.9	2.8	2.8	-2.8	-2.8	-2.8	2.8	2.8
Condit. Reinf. active responses	6.1	8.5	9.0	2.8	3.0	-2.9	-2.9	-3.0	3.0	3.0
Condit. Reinf. inactive responses	0.4	0.5	0.6	0.5	0.7	-0.7	-0.7	-0.8	0.8	0.8
Condit. Reinf. lever presses	1.2	1.6	1.8	1.2	1.3	-1.2	-1.2	-1.3	1.3	1.3
Condit. Reinf. lever reinforcers received	6.3	8.9	9.3	2.8	3.0	-2.9	-2.9	-3.0	3.0	3.0
Conditioned reinforcement - actives	0.4	0.4	1.0	-1.0	-0.6	0.6	0.7	0.6	-0.5	-0.5
Conditioned reinforcement - inactives	2.5	2.8	3.4	1.4	1.8	-1.5	-1.5	-1.8	1.9	1.9
Conditioned locomotion	3.6	4.3	9.0	-3.0	-2.0	2.3	2.2	1.6	-1.5	-1.5
Patch foraging indifference point 0 sec	1.2	1.9	2.0	-1.4	-1.4	1.3	1.3	1.4	-1.4	-1.4
Patch foraging indifference point AUC	1.4	1.6	2.0	1.0	1.3	-1.1	-1.2	-1.4	1.4	1.4
Delay disc. indifference point, 0s delay	1.2	1.3	1.5	-1.2	-1.1	1.2	1.2	1.1	-1.1	-1.1
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.2	0.2	-0.3	-0.3	-0.2	0.2	0.2
Delay disc. indifference point, 2s delay	1.5	1.6	2.1	-1.5	-1.3	1.3	1.3	1.2	-1.2	-1.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.2	-0.5	-0.4	0.4	0.4	0.4	-0.4	-0.4
Delay disc. indifference point, 4s delay	1.0	1.0	1.4	-1.2	-1.0	1.1	1.1	0.9	-0.9	-0.9
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.0	0.2	-0.1	-0.1	-0.2	0.2	0.2
Indifference point function ln k	3.1	4.3	4.4	-2.1	-2.1	2.0	2.1	2.1	-2.1	-2.1
Indifference point function log k	3.1	4.3	4.4	-2.1	-2.1	2.0	2.1	2.1	-2.1	-2.1
Patch foraging total patch changes 0 sec	1.1	1.8	1.9	-1.3	-1.3	1.3	1.3	1.4	-1.4	-1.4
Patch foraging total patch changes 12 sec	0.2	0.3	0.3	0.3	0.5	-0.5	-0.6	-0.5	0.6	0.6
Patch foraging total patch changes 18 sec	0.3	0.4	0.4	-0.6	-0.6	0.6	0.6	0.6	-0.6	-0.6
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.2	0.4	-0.2	-0.3	-0.4	0.4	0.4
Patch foraging total patch changes 6 sec	0.6	0.9	1.1	-1.0	-1.0	1.0	0.9	0.9	-0.9	-0.9
Patch foraging time to switch 0 sec	0.0	0.0	0.0	0.2	-0.1	-0.0	-0.0	0.1	-0.1	-0.1
Patch foraging water rate 0 sec	0.1	0.1	0.2	-0.5	-0.3	0.3	0.3	0.4	-0.4	-0.4
Patch foraging water rate 12 sec	0.8	1.2	1.6	-0.9	-1.1	1.0	1.0	1.3	-1.2	-1.2
Patch foraging water rate 18 sec	0.1	0.1	0.2	0.4	0.3	-0.4	-0.4	-0.3	0.3	0.3
Patch foraging water rate 24 sec	0.4	0.5	0.7	-0.4	-0.7	0.5	0.6	0.8	-0.9	-0.9
Patch foraging water rate 6 sec	2.0	3.0	3.5	-1.6	-1.7	1.5	1.6	1.9	-1.9	-1.9
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.3	0.9	0.9	-1.1	-1.1	-0.7	0.7	0.7
Distance traveled before self-admin	5.4	5.8	6.7	2.1	2.4	-2.2	-2.3	-2.6	2.6	2.6
Distance traveled after self-admin	0.0	0.1	0.1	-0.0	0.2	-0.1	-0.2	-0.3	0.3	0.3
Extensor digitorum longus weight	1.6	6.2	6.8	-2.3	-2.6	2.6	2.6	2.5	-2.4	-2.4
Bone: elastic displacement	0.1	0.1	0.3	-0.6	-0.3	0.4	0.4	0.3	-0.3	-0.3
Bone: elastic work	0.3	0.4	0.4	0.7	0.6	-0.6	-0.6	-0.6	0.6	0.6
Bone: endosteal estimation	1.6	3.5	3.7	1.9	1.8	-1.9	-1.9	-1.9	1.9	1.9
Bone: endosteal perimeter	0.3	0.6	0.8	0.8	0.7	-0.9	-0.9	-0.7	0.7	0.7
Epididymis fat weight	0.0	0.0	0.1	0.0	-0.1	-0.0	0.0	0.3	-0.2	-0.2
Delta time in closed arm before/after self-admin	0.8	0.7	1.8	-1.4	-0.8	0.9	0.9	0.6	-0.6	-0.6
Delta time in open arm before/after self-admin	4.2	4.1	4.4	1.9	2.1	-2.0	-2.0	-2.1	2.1	2.1
Diff in mean of infusions in LGA sessions	0.3	0.4	0.4	-0.5	-0.6	0.6	0.6	0.6	-0.6	-0.6
Delay discount exponential model param	0.0	0.0	0.1	0.3	0.1	-0.2	-0.2	-0.1	0.1	0.1
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.3	0.1	0.0	-0.0	-0.1	0.2	0.2
Active lever presses in extinction session 6	0.5	0.5	0.6	0.6	0.8	-0.8	-0.8	-0.7	0.7	0.7
Bone: final force	1.3	2.0	3.1	1.8	1.4	-1.5	-1.5	-1.3	1.3	1.3
Bone: final moment	0.7	1.1	1.9	1.4	1.0	-1.1	-1.1	-0.9	0.9	0.9
Food consumed during 24 hour testing period	0.8	0.9	1.1	1.0	0.9	-0.9	-1.0	-1.0	1.0	1.0
Glucose	0.9	1.3	1.5	-1.0	-1.2	1.1	1.1	1.2	-1.2	-1.2
Heart weight	0.0	0.0	0.1	0.3	-0.1	0.1	0.2	0.2	-0.2	-0.2
Delay discount hyperbolic model param	0.1	0.1	0.3	0.5	0.3	-0.4	-0.4	-0.3	0.3	0.3
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.3	-0.3	0.2	0.3	0.4	-0.4	-0.4
Intermittent access intake escalation	0.1	0.1	0.2	0.5	-0.2	0.2	0.2	0.3	-0.3	-0.3
Intermittent access intake escalation 2	0.2	0.2	1.2	1.1	0.2	-0.2	-0.2	0.0	-0.0	-0.0
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	-0.2	0.2	-0.2	-0.2	-0.2	0.1	0.1
Intermitt. access day 15 inactive lever presses	0.9	1.0	1.2	0.9	1.0	-0.9	-0.8	-1.1	1.1	1.1
Intermitt. access escalation Index	0.6	0.5	1.7	-1.3	-0.6	0.8	0.7	0.4	-0.3	-0.3
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.4	-0.0	-0.0	-0.0	-0.0	0.1	0.1
Intermittent access day 15 total infusions	0.3	0.3	0.4	-0.6	-0.6	0.5	0.5	0.6	-0.6	-0.6
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.1	-0.9	-1.0	0.8	0.8	1.1	-1.0	-1.0
Intermittent access total infusions	0.0	0.0	0.1	-0.3	-0.1	-0.0	-0.0	0.1	-0.1	-0.1
Intermittent access day 1 locomotion	0.1	0.1	0.4	-0.6	0.2	-0.1	-0.1	-0.3	0.4	0.4
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.1	0.2	-0.0	-0.0	-0.1	0.2	0.2
Intermittent access total locomotion	0.2	0.2	1.2	-1.1	-0.2	0.4	0.3	0.1	0.1	0.1
Intermittent access standard deviation	0.5	0.5	2.1	1.4	0.6	-0.7	-0.7	-0.3	0.3	0.3
Left kidney weight	0.0	0.1	0.2	-0.1	-0.2	0.5	0.5	0.2	-0.1	-0.1
Right kidney weight	0.0	0.1	0.2	-0.1	-0.4	0.3	0.3	0.4	-0.4	-0.4
Cocaine induced anxiety	1.0	1.2	1.5	-0.9	-1.2	1.1	1.2	1.2	-1.0	-1.0
Post-drug Anxiety	1.0	1.1	1.3	-0.8	-1.1	1.1	1.2	1.1	-1.0	-1.0
Baseline Anxiety	0.6	0.6	0.8	0.9	0.9	-0.7	-0.7	-0.8	0.7	0.7
Tail length	4.8	14.7	16.1	3.6	4.0	-4.0	-4.0	-3.8	3.7	3.7
Length with tail	5.1	18.5	20.9	4.6	4.3	-4.3	-4.3	-4.2	4.2	4.2
Length without tail	1.2	2.6	4.9	2.2	1.5	-1.5	-1.4	-1.5	1.5	1.5
Times rat made contact with spout	0.8	1.0	1.0	1.0	1.0	-1.0	-1.0	-1.0	1.0	1.0
Lifetime Intake	0.3	0.3	0.6	-0.8	-0.6	0.5	0.5	0.6	-0.6	-0.6
Liver weight, left	2.1	3.3	3.5	1.7	1.8	-1.8	-1.9	-1.8	1.8	1.8
Liver weight, right	1.1	1.8	1.9	1.3	1.3	-1.3	-1.3	-1.4	1.4	1.4
Locomotor activity	0.0	0.1	0.1	-0.2	-0.2	0.2	0.2	0.3	-0.3	-0.3
Locomotor testing distance	0.3	0.5	0.7	-0.6	-0.7	0.7	0.7	0.8	-0.8	-0.8
Locomotor testing rearing	0.1	0.2	0.3	-0.1	-0.4	0.3	0.4	0.5	-0.5	-0.5
Locomotion in novel chamber	0.7	0.9	1.5	-1.2	-0.9	1.0	0.9	0.8	-0.8	-0.8
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.1	-0.0	-0.0	-0.0
Fecal boli incidents, locomotor time 1	1.3	1.5	1.8	1.3	1.2	-1.2	-1.2	-1.1	1.1	1.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.2	0.4	-0.3	-0.3	-0.4	0.4	0.4
Time >=10cm from walls, locomotor time 1	3.1	3.1	3.4	1.6	1.8	-1.7	-1.7	-1.8	1.8	1.8
Bouts of movement, locomotor time 1	1.9	2.1	2.5	1.4	1.6	-1.4	-1.4	-1.4	1.4	1.4
Total resting periods, locomotor time 1	1.4	1.5	1.9	1.2	1.4	-1.2	-1.2	-1.2	1.2	1.2
Rest time, locomotor task time 1	1.9	2.1	2.1	1.4	1.5	-1.5	-1.5	-1.4	1.4	1.4
Distance moved, locomotor task time 1	0.5	0.6	0.9	-0.9	-0.8	0.8	0.8	0.6	-0.6	-0.6
Vertical activity count, locomotor time 1	1.1	1.2	1.5	-1.2	-1.1	1.2	1.2	1.0	-1.0	-1.0
Time >=10cm from walls, locomotor time 2	0.7	0.7	0.8	0.9	0.9	-0.9	-0.9	-0.8	0.8	0.8
Bouts of movement, locomotor time 2	0.6	0.7	0.8	-0.7	-0.8	0.7	0.7	0.9	-0.9	-0.9
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.3	-0.3	0.3	0.3	0.4	-0.4	-0.4
Rest time, locomotor task time 2	2.0	2.3	2.6	1.3	1.5	-1.4	-1.4	-1.6	1.6	1.6
Distance moved, locomotor task time 2	0.8	0.9	1.0	-1.0	-1.0	1.0	0.9	0.9	-0.9	-0.9
Vertical activity count, locomotor time 2	4.1	4.4	4.6	-2.1	-2.1	2.1	2.1	2.1	-2.1	-2.1
Light reinforcement 1	1.4	2.6	3.3	-1.5	-1.8	1.7	1.6	1.6	-1.6	-1.6
Light reinforcement 2	0.7	0.9	1.5	1.2	0.8	-1.0	-1.0	-0.9	0.9	0.9
Bone: marrow area	1.6	3.4	3.6	1.8	1.8	-1.9	-1.9	-1.8	1.8	1.8
Bone: maximum diameter	1.0	1.8	2.1	1.4	1.3	-1.4	-1.4	-1.3	1.3	1.3
Bone: maximum force	0.6	1.0	1.8	1.3	0.9	-1.1	-1.0	-0.8	0.8	0.8
Bone: maximum moment	0.2	0.3	0.8	0.9	0.5	-0.6	-0.6	-0.4	0.4	0.4
Mean time between licks in bursts	0.5	0.6	0.7	-0.7	-0.8	0.8	0.8	0.8	-0.8	-0.8
Mean num. licks in bursts	0.6	0.7	0.8	0.7	0.9	-0.8	-0.8	-0.9	0.9	0.9
Cd content in liver	0.5	0.5	0.7	-0.8	-0.7	0.7	0.8	0.7	-0.6	-0.6
Co content in liver	0.3	0.3	0.6	-0.8	-0.6	0.5	0.6	0.5	-0.5	-0.5
Cu content in liver	0.0	0.0	0.0	0.1	-0.1	0.0	0.0	0.1	-0.1	-0.1
Fe content in liver	0.0	0.0	0.1	0.3	0.2	-0.3	-0.2	-0.1	0.1	0.1
K content in liver	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	0.1	-0.1	-0.1
Mg content in liver	0.4	0.5	0.5	-0.5	-0.7	0.7	0.7	0.7	-0.7	-0.7
Mn content in liver	2.5	2.8	2.9	-1.7	-1.7	1.6	1.7	1.7	-1.7	-1.7
Na content in liver	1.2	1.3	1.5	1.2	1.1	-1.0	-1.1	-1.2	1.2	1.2
Rb content in liver	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0	0.1	-0.1	-0.1
Se content in liver	0.9	1.0	1.2	-0.9	-1.0	0.9	1.0	1.1	-1.1	-1.1
Sr content in liver	0.2	0.2	0.2	0.5	0.4	-0.4	-0.4	-0.5	0.5	0.5
Zn content in liver	0.3	0.4	0.4	-0.5	-0.6	0.6	0.6	0.7	-0.6	-0.6
Bone: minimum diameter	1.3	2.5	2.8	1.6	1.5	-1.7	-1.7	-1.5	1.5	1.5
Time in familiar zone, hab. session 1	2.4	2.2	2.5	-1.5	-1.6	1.5	1.5	1.5	-1.5	-1.5
Time in novel zone, hab. session 1	6.7	6.5	6.9	2.6	2.6	-2.6	-2.6	-2.5	2.5	2.5
Total zone transitions, hab. session 1	0.6	0.9	1.0	1.0	0.9	-0.9	-0.9	-0.9	0.9	0.9
Total locomotion distance, hab. session 1	2.0	2.9	3.3	1.8	1.7	-1.7	-1.7	-1.6	1.6	1.6
Locomotion velocity, hab. session 1	1.6	2.2	2.7	1.7	1.5	-1.5	-1.5	-1.4	1.4	1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.3	-0.4	0.4	0.4	0.3	-0.2	-0.2
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.0	0.1	-0.1	-0.1
Total zone transitions, hab. session 2	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.0	-0.0	-0.0
Total locomotion distance, hab. session 2	0.0	0.0	0.1	0.2	0.2	-0.2	-0.2	-0.1	0.1	0.1
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.2	0.2	-0.2	-0.2	-0.1	0.1	0.1
Novel to familiar place preference ratio	1.4	1.5	1.6	1.2	1.2	-1.2	-1.2	-1.2	1.2	1.2
Novelty place preference	2.0	2.0	2.2	1.5	1.4	-1.4	-1.4	-1.4	1.4	1.4
Time in novel zone, NPP test	2.2	2.3	2.4	1.5	1.5	-1.5	-1.5	-1.5	1.5	1.5
Total zone transitions, NPP test	0.2	0.3	0.4	0.6	0.6	-0.6	-0.6	-0.6	0.6	0.6
Total locomotion distance, NPP test	0.6	0.9	1.0	1.0	0.9	-0.9	-0.9	-0.9	0.9	0.9
Locomotion velocity, NPP test	0.3	0.4	0.5	0.7	0.6	-0.6	-0.6	-0.6	0.6	0.6
Intraocular pressure	3.3	4.7	5.9	-2.4	-2.2	2.1	2.1	2.1	-2.1	-2.1
Delta distance traveled before/after self-admin	3.1	3.3	3.7	-1.8	-1.7	1.7	1.7	1.9	-1.9	-1.9
Delta ambulatory time before/after self-admin	2.8	3.1	3.6	-1.7	-1.7	1.6	1.6	1.9	-1.9	-1.9
Parametrial fat weight	0.3	0.5	0.9	1.0	0.7	-0.8	-0.8	-0.6	0.6	0.6
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.3	-0.3	0.3	0.3	0.3	-0.3	-0.3
Pavlov. Cond. magazine entry latency	0.4	0.6	0.7	0.8	0.8	-0.8	-0.8	-0.7	0.7	0.7
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.2	-0.1	0.2	0.2	0.1	-0.1	-0.1
Pavlov. Cond. index score	0.5	0.7	0.7	0.8	0.8	-0.8	-0.8	-0.8	0.8	0.8
Pavlov. Cond. latency score	0.4	0.6	0.6	0.8	0.8	-0.7	-0.8	-0.7	0.7	0.7
Pavlov. Cond. lever contacts	0.3	0.3	0.4	0.5	0.6	-0.5	-0.6	-0.6	0.6	0.6
Pavlov. Cond. magazine entry number	0.2	0.3	0.3	-0.5	-0.5	0.6	0.6	0.5	-0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.1	0.1	-0.0	-0.0	-0.1	0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	0.8	0.9	0.9	-0.9	-0.9	-0.9	0.9	0.9
Pavlov. Cond. response bias	0.6	0.8	0.8	0.9	0.9	-0.9	-0.9	-0.9	0.9	0.9
Pavlov. Cond. lever latency	1.3	1.7	1.8	-1.3	-1.3	1.3	1.3	1.3	-1.3	-1.3
Pavlov. Cond. magazine entry latency	0.3	0.4	0.4	0.6	0.6	-0.6	-0.6	-0.7	0.7	0.7
Pavlov. Cond. change in total contacts	1.7	2.3	2.5	1.3	1.5	-1.5	-1.5	-1.6	1.6	1.6
Pavlov. Cond. index score	2.1	2.7	2.9	1.6	1.7	-1.6	-1.6	-1.7	1.7	1.7
Pavlov. Cond. latency score	2.0	2.4	2.6	1.5	1.6	-1.5	-1.5	-1.6	1.6	1.6
Pavlov. Cond. lever contacts	2.3	3.2	3.2	1.7	1.8	-1.8	-1.8	-1.8	1.8	1.8
Pavlov. Cond. magazine entry number	1.1	1.4	1.5	-1.1	-1.2	1.1	1.1	1.2	-1.2	-1.2
Pavlov. Cond. intertrial magazine entries	2.2	2.8	3.0	-1.6	-1.7	1.7	1.7	1.7	-1.7	-1.7
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	2.6	1.5	1.6	-1.5	-1.5	-1.6	1.6	1.6
Pavlov. Cond. response bias	2.4	3.2	3.3	1.8	1.8	-1.8	-1.8	-1.8	1.8	1.8
Time in closed arm before self-admin	1.7	1.9	2.2	1.4	1.3	-1.2	-1.1	-1.5	1.5	1.5
Time in closed arm after self-admin	0.1	0.1	0.1	0.2	0.2	-0.2	-0.1	-0.3	0.3	0.3
Time in open arm before self-admin	3.0	3.2	3.7	-1.9	-1.8	1.7	1.7	1.8	-1.8	-1.8
Time in open arm after self-admin	1.4	1.6	1.8	1.1	1.2	-1.3	-1.3	-1.3	1.3	1.3
Bone: periosteal estimation	1.7	3.6	3.9	2.0	1.9	-2.0	-2.0	-1.8	1.8	1.8
Bone: periosteal perimeter	1.3	2.1	2.4	1.5	1.4	-1.6	-1.5	-1.4	1.4	1.4
Bone: post-yield work	0.1	0.1	0.2	-0.3	-0.4	0.2	0.3	0.4	-0.4	-0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.8	-0.9	0.0	-0.1	-0.1	-0.1	0.2	0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.7	-0.8	0.1	-0.2	-0.2	-0.2	0.3	0.3
Progressive ratio test 1 inactive lever presses	1.5	1.6	3.7	-1.9	-1.2	1.2	1.2	1.1	-1.1	-1.1
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.3	-0.2	0.2	0.2	0.1	-0.0	-0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0	-0.1	0.2	0.2
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	-0.2	-0.0	0.2	0.2	-0.1	0.2	0.2
Incentive Sensitization - Responses	0.4	0.4	0.7	0.3	0.6	-0.5	-0.6	-0.7	0.8	0.8
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	0.3	0.5	-0.4	-0.5	-0.6	0.7	0.7
Sum of active levers in priming session hrs 5-6	1.4	1.4	1.7	0.9	1.2	-1.1	-1.1	-1.3	1.3	1.3
Progressive ratio	0.0	0.0	0.1	-0.0	-0.3	0.1	0.1	0.3	-0.3	-0.3
Food seeking constrained by brief footshock	1.5	1.9	2.4	-1.5	-1.4	1.4	1.4	1.3	-1.3	-1.3
Seeking ratio, punishment vs. effort	0.4	0.5	1.0	-1.0	-0.7	0.8	0.8	0.5	-0.5	-0.5
Retroperitoneal fat weight	0.8	2.5	2.7	-1.3	-1.6	1.6	1.6	1.6	-1.6	-1.6
Reaction time number correct	0.7	0.9	1.1	-0.9	-1.0	0.9	0.9	1.0	-1.1	-1.1
Reaction time mean minus median	0.0	0.0	0.1	-0.3	0.1	-0.2	-0.2	-0.1	0.1	0.1
Reaction time mean minus median AUC	0.1	0.1	0.2	0.2	0.3	-0.5	-0.5	-0.3	0.4	0.4
Reaction time num false alarms	4.1	5.6	5.9	-2.3	-2.3	2.3	2.3	2.4	-2.4	-2.4
Reaction time num false alarms AUC	3.8	5.2	5.6	-2.2	-2.2	2.2	2.2	2.3	-2.4	-2.4
Reaction time trials correct on left	0.7	0.9	1.1	-0.9	-1.0	0.9	0.9	1.0	-1.1	-1.1
Reaction time trials on left	0.7	1.0	1.2	-0.9	-1.0	0.9	1.0	1.0	-1.1	-1.1
Reaction time mean	3.5	4.8	5.3	1.9	2.2	-2.3	-2.3	-2.2	2.2	2.2
Reaction time mean AUC	2.6	3.6	4.0	1.6	1.9	-2.0	-2.0	-1.9	1.9	1.9
Median of all reaction times	5.0	6.8	7.2	2.4	2.6	-2.7	-2.7	-2.6	2.6	2.6
Reaction time omissions	0.1	0.2	0.3	-0.5	-0.3	0.4	0.4	0.3	-0.5	-0.5
Reaction time false alarm rate	1.6	2.3	2.4	-1.5	-1.5	1.5	1.5	1.5	-1.6	-1.6
Reaction time premature initiation rate	0.3	0.4	0.6	0.8	0.6	-0.6	-0.6	-0.6	0.6	0.6
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.1	0.0	0.1	0.0	-0.1	-0.1
Std. dev. reaction times	0.5	0.8	1.0	0.5	0.9	-1.0	-1.0	-0.8	0.9	0.9
Reaction time trials completed	0.7	1.0	1.2	-0.9	-1.0	0.9	1.0	1.0	-1.1	-1.1
Reaction time trials AUC	0.5	0.7	0.8	-0.8	-0.8	0.8	0.8	0.8	-0.9	-0.9
Run reversals in cocaine runway, females	1.0	1.0	1.3	-0.3	-1.0	1.1	1.1	1.1	-1.1	-1.1
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.6	0.2	-0.3	-0.3	-0.1	0.1	0.1
Latency to leave start box in cocaine runway	3.3	3.5	4.3	-1.6	-2.0	1.7	1.7	2.0	-2.1	-2.1
Latency to leave start box in cocaine runway, F	2.6	2.8	3.2	-1.5	-1.7	1.6	1.6	1.8	-1.8	-1.8
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.1	0.3	-0.3	-0.3
Std. dev. time between licks in bursts	3.0	3.6	3.9	-1.7	-1.9	1.9	1.9	2.0	-2.0	-2.0
Total sessions with >9 infusions	0.3	0.4	0.6	-0.7	-0.6	0.3	0.4	0.8	-0.7	-0.7
Short access day 1 total inactive lever presses	0.1	0.1	0.4	-0.6	0.1	0.1	0.0	-0.3	0.3	0.3
Short access day 10 total inactive lever presses	0.9	1.0	2.2	1.5	1.0	-1.0	-1.0	-0.8	0.7	0.7
Short access day 1 total infusions	0.6	0.6	1.6	-1.3	-0.7	0.6	0.6	0.7	-0.7	-0.7
Short access day 10 total infusions	0.1	0.1	0.1	0.0	0.3	-0.4	-0.4	-0.2	0.2	0.2
Short access total infusions	0.8	1.0	1.4	-1.2	-1.0	0.9	0.9	1.0	-0.9	-0.9
Short access day 1 locomotion	0.9	1.0	1.1	0.7	1.1	-1.0	-1.0	-1.0	1.0	1.0
Short access day 10 total locomotion	0.5	0.5	1.0	-0.1	0.7	-0.5	-0.5	-0.8	1.0	1.0
Short access total locomotion	0.1	0.1	0.3	-0.5	0.1	0.1	0.0	-0.2	0.4	0.4
One hour access (0.3 mA shock)	0.3	0.3	0.5	0.7	0.6	-0.6	-0.6	-0.5	0.5	0.5
Compulsive drug intake	0.4	0.4	0.6	0.7	0.7	-0.5	-0.5	-0.6	0.6	0.6
One hour access (shock baseline)	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.2	-0.2	-0.2
Social response proportion	0.6	0.6	1.0	0.4	0.7	-0.6	-0.7	-0.9	1.0	1.0
Social responses	0.7	0.9	1.0	0.7	0.9	-0.9	-1.0	-0.9	1.0	1.0
Social time	0.4	0.5	0.6	0.6	0.7	-0.7	-0.7	-0.7	0.8	0.8
Soleus weight	0.0	0.1	0.2	0.4	0.3	-0.1	-0.2	-0.4	0.4	0.4
Bone: stiffness	0.5	0.8	1.4	1.2	0.8	-0.9	-0.9	-0.8	0.8	0.8
Tibialis anterior weight	0.2	0.8	1.1	-0.6	-1.0	1.1	1.0	0.9	-0.8	-0.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.6	-0.3	0.3	0.3	0.3	-0.2	-0.2
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.5	0.7	0.5	-0.6	-0.6	-0.3	0.3	0.3
Time to tail flick, test, before self-admin	0.1	0.1	0.5	0.7	0.3	-0.4	-0.3	-0.2	0.2	0.2
Time to tail flick, test, after self-admin	1.7	1.8	3.4	-1.8	-1.2	1.4	1.4	1.1	-1.1	-1.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.1	-0.2	0.1	0.2	0.3	-0.3	-0.3
Delta time to tail flick, test, before/after SA	0.9	0.8	2.3	-1.5	-0.7	1.0	0.9	0.4	-0.5	-0.5
Tibia length	1.6	4.5	4.8	2.2	2.1	-2.1	-2.1	-2.1	2.1	2.1
Ambulatory time before self-admin	2.8	2.9	3.9	1.0	1.7	-1.6	-1.6	-2.0	2.0	2.0
Ambulatory time after self-admin	0.5	0.5	1.1	-1.0	-0.7	0.9	0.8	0.5	-0.5	-0.5
Bone: tissue strength	0.9	0.8	1.0	-0.8	-0.9	0.8	0.9	1.0	-1.0	-1.0
Total heroin consumption	0.6	0.8	1.1	1.1	0.9	-0.9	-0.9	-0.8	0.8	0.8
Bone: trabecular number	0.1	0.1	0.2	-0.3	-0.4	0.4	0.4	0.3	-0.3	-0.3
Bone: trabecular spacing	0.1	0.2	0.2	0.4	0.5	-0.5	-0.5	-0.4	0.4	0.4
Bone: trabecular thickness	0.3	0.4	0.5	0.7	0.6	-0.7	-0.7	-0.6	0.6	0.6
Bone: trabecular tissue density	0.6	0.8	0.9	0.8	0.9	-0.9	-0.9	-0.9	0.9	0.9
Water consumed over 24 hours	0.1	0.1	0.2	-0.2	-0.4	0.4	0.4	0.4	-0.4	-0.4
Number of responses in last shaping day	0.1	0.1	0.3	0.2	0.2	-0.5	-0.5	-0.1	0.1	0.1