Hub : Genes

Metrnl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Metrnl	0.04	0.02	2.1e-05	0.02	0.04	0.03	0.01	1.5e-03	4.4e-05	6.3e-04	3.3e-02
2	PL	gene expression	Metrnl	0.05	0.03	3.7e-05	0.04	0.04	0.05	0.05	7.3e-05	3.4e-05	5.0e-06	4.5e-06
3	Brain	gene expression	Metrnl	0.11	0.05	3.7e-06	0.05	0.05	0.07	0.06	1.7e-05	8.2e-06	6.4e-07	1.1e-06
4	OFC	gene expression	Metrnl	0.23	0.12	4.3e-03	0.02	0.02	0.03	0.02	1.1e-01	1.1e-01	8.6e-02	8.9e-02
5	NAcc	gene expression	Metrnl	0.04	0.03	3.2e-03	0.01	0.02	0.02	0.01	2.2e-02	1.3e-03	3.9e-03	8.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.1	0.1	0.4	-0.3	0.0	-0.6	0.0	0.4
Area under the delay curve	1.4	1.4	3.1	1.8	1.4	-0.8	-0.8	1.0
BMI with tail	0.4	1.2	3.9	-2.0	-1.1	-0.6	0.3	-0.6
BMI without tail	1.3	2.6	8.1	-2.9	0.1	-0.6	-1.9	0.9
Body weight	1.1	4.7	16.7	-4.1	-1.8	-1.7	0.2	-0.6
Weight adjusted by age	1.8	2.0	4.4	-2.1	-1.5	-0.3	1.3	-1.2
Bone surface	0.1	0.2	0.5	-0.7	-0.2	-0.7	-0.2	0.2
Bone volume	0.1	0.1	0.4	-0.6	-0.2	-0.3	0.0	0.1
Breakpoint value in progressive ratio session	0.2	0.2	0.7	0.3	-0.2	-0.2	-0.2	-0.8
Number of licking bursts	0.1	0.1	0.3	-0.2	0.3	0.0	-0.6	0.5
Context. condit. distance diff. score	0.6	0.7	1.1	-0.4	0.9	-0.7	-1.0	1.0
Locomotion velocity, session 1	1.4	1.5	2.5	0.7	-0.9	1.5	1.2	-1.6
Locomotion distance, session 1	1.5	1.9	2.8	1.3	1.7	-1.5	-1.1	1.3
Locomotion velocity, session 2	1.4	1.7	5.1	2.3	1.4	-0.5	-0.7	0.7
Locomotion distance, session 2	1.5	2.0	2.8	0.6	1.4	-1.5	-1.7	1.6
Locomotion velocity, session 3	0.8	0.9	3.7	1.9	0.5	-0.6	-0.1	0.4
Locomotion distance, session 3	2.0	2.2	6.2	2.5	1.5	-1.0	-0.9	1.1
Stereotopy head waving bouts, day 3	0.2	0.2	0.7	0.1	-0.3	-0.0	0.9	-0.5
Stereotopy head waving duration, day 3	0.1	0.1	0.3	-0.2	-0.0	-0.5	0.3	-0.2
Locomotion velocity, session 7	0.9	0.9	1.5	1.2	1.0	-0.8	-1.0	0.8
Locomotion distance, session 7	2.8	3.6	6.3	2.5	2.2	-0.9	-1.6	1.8
Stereotopy head waving bouts, day 7	0.3	0.4	1.3	-1.1	-0.3	-0.7	-0.2	-0.2
Stereotopy head waving duration, day 7	0.3	0.4	1.3	-1.1	-0.4	-0.6	0.1	-0.3
Locomotion velocity, session 8	1.8	2.1	4.1	0.9	1.4	-2.0	-0.8	1.7
Locomotion distance, session 8	3.4	5.0	7.0	-0.0	2.2	-2.4	-2.7	2.6
Degree of sensitization distance	0.1	0.1	0.3	-0.5	-0.0	0.4	-0.2	0.3
Degree of sensitization stereotypy	0.3	0.3	1.2	-1.1	-0.2	-0.5	-0.4	-0.1
Conditioned locomotion	0.9	1.1	4.6	-2.1	-0.4	-0.6	-0.0	0.4
Cocaine response after cond. corrected	0.2	0.2	0.5	0.6	-0.2	0.4	0.7	-0.4
Cocaine response after cond. not corrected	0.3	0.3	1.1	1.1	0.5	0.0	0.1	0.0
Cocaine response before conditioning	1.7	2.0	3.1	1.0	1.8	-1.0	-1.7	1.4
Saline control response	0.2	0.3	1.0	-1.0	-0.6	0.0	0.0	0.5
Bone: connectivity density	0.5	0.8	1.6	0.4	0.9	-1.1	-0.7	1.3
Bone: cortical apparent density	0.8	1.0	4.3	2.1	0.5	0.6	0.2	0.0
Bone: cortical area	3.3	5.0	13.7	-3.7	-2.2	-2.2	1.0	-0.8
Bone: cortical porosity	3.1	3.3	5.8	-1.4	-2.1	1.3	1.6	-2.4
Bone: cortical porosity	2.6	2.8	4.5	-1.6	-2.0	1.1	1.4	-2.1
Bone: cortical thickness	3.9	6.3	13.5	-3.7	-3.2	-1.0	2.0	-1.7
Bone: cortical thickness	2.2	2.5	4.6	-2.1	-2.0	0.4	1.3	-1.4
Bone: cortical tissue density	0.9	1.2	4.9	2.2	0.5	0.9	0.3	-0.1
Condit. Reinf. active minus inactive responses	0.6	0.7	2.3	-1.5	-0.9	-0.2	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.5	-0.7	-0.6	-1.2	0.1	0.3
Condit. Reinf. active responses	1.1	1.3	4.9	-2.2	-1.1	0.5	-0.0	-0.5
Condit. Reinf. inactive responses	0.7	0.8	2.0	-1.2	-0.5	1.4	-0.1	-0.6
Incentive salience index mean	0.3	0.4	1.7	-1.3	-0.4	-0.3	-0.2	0.0
Condit. Reinf. lever presses	0.3	0.4	0.9	0.2	0.9	-0.1	-0.9	0.5
Condit. Reinf. active minus inactive responses	0.8	1.0	2.4	-1.5	-0.6	-1.6	0.5	0.1
Condit. Reinf. active-inactive response ratio	2.1	2.2	5.4	-2.3	-1.7	-0.2	1.4	-1.1
Condit. Reinf. active responses	0.5	0.7	2.9	-0.7	0.0	-1.7	-0.0	0.6
Condit. Reinf. inactive responses	1.1	1.4	2.3	1.2	1.0	-1.5	-0.8	1.2
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.2	0.4	-0.7	-0.8	0.8
Condit. Reinf. lever reinforcers received	0.6	0.8	3.1	-0.7	0.2	-1.8	-0.3	0.7
Conditioned reinforcement - actives	0.4	0.4	1.0	0.1	1.0	0.3	-0.8	0.7
Conditioned reinforcement - inactives	0.2	0.2	0.9	-0.1	-0.1	1.0	-0.5	-0.1
Conditioned locomotion	0.6	0.7	1.4	0.3	1.1	-0.2	-1.2	0.9
Patch foraging indifference point 0 sec	0.0	0.1	0.2	0.5	0.2	-0.2	0.0	0.3
Patch foraging indifference point AUC	0.4	0.5	1.7	-0.5	-0.3	1.3	0.2	-0.6
Delay disc. indifference point, 0s delay	0.3	0.3	1.1	0.1	0.1	-1.1	0.5	0.3
Delay disc. indifference point, 16s delay	4.1	4.1	6.7	2.0	2.6	-1.4	-2.1	2.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.6	0.4	-0.4	-0.1	0.1
Delay disc. indifference point, 24s delay	1.7	1.6	5.2	2.3	1.3	-0.7	-0.7	0.4
Delay disc. indifference point, 4s delay	0.7	0.8	1.8	1.3	0.6	-0.9	0.3	1.0
Delay disc. indifference point, 8s delay	0.3	0.3	1.4	1.2	0.4	-0.1	0.2	0.0
Indifference point function ln k	1.0	1.4	2.4	1.2	1.2	-1.6	-0.3	1.3
Indifference point function log k	1.0	1.4	2.4	1.2	1.2	-1.6	-0.3	1.3
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.5	0.4	-0.4	-0.1	0.5
Patch foraging total patch changes 12 sec	0.6	0.8	2.7	-0.1	-0.4	1.6	0.5	-1.0
Patch foraging total patch changes 18 sec	0.5	0.6	1.1	0.7	1.0	-0.5	-0.7	0.8
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.2	-0.0
Patch foraging total patch changes 6 sec	0.4	0.6	1.4	-0.6	-0.7	1.2	0.5	-0.7
Patch foraging time to switch 0 sec	0.1	0.2	0.4	0.6	0.7	-0.2	-0.1	0.0
Patch foraging water rate 0 sec	0.1	0.2	0.5	-0.3	0.2	-0.1	-0.5	0.7
Patch foraging water rate 12 sec	0.1	0.2	0.4	-0.1	0.6	-0.5	-0.1	0.5
Patch foraging water rate 18 sec	1.2	1.6	3.6	-0.3	1.2	-1.9	-0.9	1.4
Patch foraging water rate 24 sec	1.5	2.1	5.5	-0.4	1.0	-2.3	-1.2	1.6
Patch foraging water rate 6 sec	0.4	0.6	1.2	0.6	0.7	-1.1	-0.6	0.8
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	1.0	-1.0	-0.5	0.1	0.6	-0.0
Distance traveled before self-admin	0.3	0.3	0.9	-0.3	-1.0	-0.1	0.6	-0.3
Distance traveled after self-admin	0.7	0.8	1.5	0.1	1.1	0.8	-1.2	0.8
Extensor digitorum longus weight	0.2	0.9	1.4	-1.0	0.7	-1.2	-1.0	0.9
Bone: elastic displacement	1.1	1.2	3.3	-1.2	-1.8	0.3	1.0	-0.5
Bone: elastic work	7.6	9.8	18.8	-3.6	-4.3	1.1	3.0	-2.6
Bone: endosteal estimation	0.9	2.0	4.1	-0.1	1.6	-2.0	-1.4	1.1
Bone: endosteal perimeter	0.3	0.7	2.4	-1.1	-0.1	-1.6	0.1	0.2
Epididymis fat weight	0.2	0.4	1.6	-1.3	0.1	-0.3	-0.6	0.1
Delta time in closed arm before/after self-admin	0.3	0.3	0.7	0.2	0.1	0.8	0.8	-0.1
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.6	0.4	0.1	-0.6	0.1
Diff in mean of infusions in LGA sessions	0.2	0.3	1.2	1.1	0.3	0.1	-0.3	0.1
Delay discount exponential model param	1.4	1.5	4.1	-2.0	-1.3	0.6	0.7	-0.9
Extinction: sum of active levers before priming	1.3	1.3	2.0	0.7	-1.3	1.0	1.2	-1.4
Active lever presses in extinction session 6	0.6	0.5	2.1	1.4	0.2	-0.5	-0.3	-0.5
Bone: final force	2.7	4.4	12.2	-3.5	-2.2	-2.0	0.6	-0.7
Bone: final moment	3.3	5.3	14.5	-3.8	-2.6	-1.8	1.0	-1.0
Food consumed during 24 hour testing period	0.2	0.2	0.3	-0.5	-0.5	0.6	0.3	-0.1
Glucose	1.9	2.9	6.5	0.9	-1.4	1.4	1.8	-2.5
Heart weight	1.1	1.6	5.2	-2.3	-1.1	-0.3	0.5	-1.1
Delay discount hyperbolic model param	1.4	1.5	4.0	-2.0	-1.3	0.7	0.6	-0.9
Intermittent access intake day 1-15 change	0.2	0.2	0.7	0.4	0.0	0.8	-0.5	0.3
Intermittent access intake escalation	0.5	0.5	1.4	0.5	0.3	0.6	-1.2	0.6
Intermittent access intake escalation 2	0.4	0.4	0.9	-0.1	-1.0	0.8	-0.2	-0.6
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.7	-0.3	-0.8	0.2	0.2	-0.4
Intermitt. access day 15 inactive lever presses	1.0	1.1	2.3	0.1	0.6	-1.2	-1.1	1.5
Intermitt. access escalation Index	0.2	0.1	0.4	-0.6	-0.3	-0.1	0.1	0.4
Intermittent access day 1 total infusions	0.2	0.3	1.2	-1.1	0.3	0.2	-0.2	0.1
Intermittent access day 15 total infusions	0.2	0.2	0.4	-0.3	0.3	0.5	-0.7	0.4
Intermittent access terminal intake (last 3 days)	0.3	0.3	1.2	-0.4	-0.2	1.1	-0.1	-0.0
Intermittent access total infusions	0.2	0.2	0.3	-0.5	0.5	0.4	-0.4	0.6
Intermittent access day 1 locomotion	0.5	0.5	1.0	0.2	1.0	-0.5	-0.7	1.0
Intermittent access day 15 total locomotion	0.1	0.2	0.4	-0.0	0.2	-0.1	-0.6	0.7
Intermittent access total locomotion	0.4	0.4	0.9	0.3	0.5	-0.3	-0.8	1.0
Intermittent access standard deviation	0.7	0.7	2.5	1.6	0.4	0.8	-0.3	-0.2
Left kidney weight	0.5	1.5	2.5	-1.6	-1.0	-1.4	1.0	-1.0
Right kidney weight	0.3	0.7	2.4	-1.0	-0.3	-1.6	0.5	-0.2
Cocaine induced anxiety	4.7	5.4	8.4	-1.4	-2.9	1.5	2.8	-2.6
Post-drug Anxiety	0.9	1.0	2.3	0.2	-1.1	0.4	1.5	-1.1
Baseline Anxiety	5.3	5.7	7.2	2.5	2.7	-2.3	-2.0	2.4
Tail length	0.9	2.7	8.7	-3.0	0.1	-0.7	-1.8	1.1
Length with tail	0.5	1.9	7.0	-2.6	-1.1	-1.1	0.2	-0.3
Length without tail	0.8	1.8	3.6	-0.3	-1.3	-0.6	1.9	-1.8
Times rat made contact with spout	3.6	4.2	7.9	-1.5	-2.1	2.8	1.5	-2.0
Lifetime Intake	0.2	0.2	0.8	-0.1	0.3	0.9	-0.1	0.3
Liver weight, left	0.3	0.5	1.3	-0.3	-0.7	0.4	0.6	-1.1
Liver weight, right	0.5	0.9	3.0	-1.7	-0.9	-0.6	-0.2	-0.3
Locomotor activity	0.3	0.4	0.8	0.9	0.8	-0.3	-0.7	0.2
Locomotor testing distance	0.7	1.2	2.0	1.0	1.4	-1.3	-0.8	0.8
Locomotor testing rearing	0.7	1.1	1.9	1.4	1.3	0.1	-1.0	0.8
Locomotion in novel chamber	0.2	0.3	0.8	0.3	0.6	-0.9	0.3	0.5
Locomotion in novel chamber post-restriction	0.8	0.9	3.3	-1.8	-0.8	0.4	0.5	-0.4
Fecal boli incidents, locomotor time 1	0.4	0.4	1.4	0.1	0.6	-0.2	-1.2	0.3
Change in fecal boli incidents, locomotor task	1.5	1.4	2.2	1.3	-0.0	1.5	1.3	-1.2
Time >=10cm from walls, locomotor time 1	1.2	1.2	2.8	0.4	0.8	-1.4	-0.7	1.7
Bouts of movement, locomotor time 1	0.2	0.2	0.3	0.4	-0.2	0.6	0.4	-0.4
Total resting periods, locomotor time 1	0.2	0.3	0.5	0.6	-0.3	0.7	0.4	-0.5
Rest time, locomotor task time 1	0.2	0.3	0.8	-0.2	-0.4	0.9	0.1	-0.6
Distance moved, locomotor task time 1	0.8	0.9	1.7	1.1	1.3	-0.9	-0.6	0.8
Vertical activity count, locomotor time 1	0.7	0.7	1.3	0.2	0.8	-1.1	-0.7	1.0
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.9	-1.0	-0.6	-0.5	0.6	0.2
Bouts of movement, locomotor time 2	0.3	0.4	1.0	1.0	0.6	-0.5	-0.2	0.4
Total resting periods, locomotor time 2	0.5	0.6	0.9	0.8	0.9	-0.7	-0.6	0.8
Rest time, locomotor task time 2	0.1	0.1	0.4	-0.2	0.0	0.7	-0.1	-0.1
Distance moved, locomotor task time 2	0.1	0.1	0.4	0.4	0.6	-0.2	0.2	0.2
Vertical activity count, locomotor time 2	1.0	1.1	2.1	-0.1	1.0	-1.4	-1.2	0.9
Light reinforcement 1	0.4	0.8	1.8	-1.3	-0.6	0.9	1.0	-0.3
Light reinforcement 2	0.5	0.7	2.6	-1.6	-0.6	0.4	0.5	-0.5
Bone: marrow area	0.9	2.0	4.2	-0.1	1.6	-2.0	-1.4	1.1
Bone: maximum diameter	0.9	1.7	5.0	-1.8	-0.4	-2.2	0.1	0.2
Bone: maximum force	2.9	5.0	15.0	-3.9	-2.1	-2.2	0.5	-0.7
Bone: maximum moment	3.4	5.9	17.7	-4.2	-2.5	-2.0	0.9	-1.0
Mean time between licks in bursts	0.8	1.2	3.3	1.8	1.4	-0.2	-0.5	0.6
Mean num. licks in bursts	1.2	1.4	1.7	-0.7	-1.3	1.3	1.3	-1.3
Cd content in liver	0.6	0.7	1.6	1.3	1.0	-0.4	-0.7	0.4
Co content in liver	0.4	0.4	0.8	0.7	0.9	-0.6	-0.6	0.4
Cu content in liver	0.5	0.6	1.3	-0.2	-1.1	0.9	0.7	-0.8
Fe content in liver	1.6	1.9	2.5	1.6	1.5	-1.4	-1.2	1.1
K content in liver	0.4	0.4	0.9	-0.4	0.5	0.2	-0.9	0.8
Mg content in liver	2.0	2.0	4.0	0.7	1.7	-0.0	-2.0	1.6
Mn content in liver	0.1	0.1	0.2	-0.3	-0.1	0.5	0.1	-0.1
Na content in liver	0.1	0.1	0.5	0.7	0.2	-0.1	-0.0	0.4
Rb content in liver	0.4	0.5	0.9	-0.8	0.1	-0.6	-0.9	0.9
Se content in liver	0.2	0.2	1.1	0.1	-0.0	1.0	0.3	0.1
Sr content in liver	1.9	1.7	3.5	-0.1	-1.3	1.2	1.9	-1.4
Zn content in liver	0.3	0.4	0.6	0.4	0.7	-0.7	-0.8	0.4
Bone: minimum diameter	1.2	2.2	6.2	-2.5	-1.4	-1.2	1.0	-0.6
Time in familiar zone, hab. session 1	0.6	0.5	1.0	-0.3	-0.7	0.9	0.6	-1.0
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.2	0.2	0.2	0.0	0.3
Total zone transitions, hab. session 1	0.1	0.1	0.3	0.4	0.5	-0.0	-0.5	0.4
Total locomotion distance, hab. session 1	0.2	0.3	0.8	-0.7	0.2	-0.3	-0.9	0.5
Locomotion velocity, hab. session 1	0.4	0.5	1.2	-0.7	0.4	-0.5	-1.1	0.6
Time in familiar zone, hab. session 2	0.2	0.2	0.5	0.5	0.7	0.4	-0.4	-0.0
Time in novel zone, hab. session 2	0.1	0.1	0.4	0.2	-0.1	-0.6	0.2	0.3
Total zone transitions, hab. session 2	0.8	1.0	1.5	-0.2	1.2	-0.8	-1.1	1.1
Total locomotion distance, hab. session 2	0.7	0.9	1.5	-1.1	0.9	-0.5	-1.2	1.0
Locomotion velocity, hab. session 2	0.8	1.0	1.6	-1.3	0.7	-0.6	-1.2	1.0
Novel to familiar place preference ratio	3.0	3.1	5.0	-1.9	-2.2	1.0	1.9	-1.6
Novelty place preference	3.2	3.3	5.3	-1.9	-2.3	0.9	2.1	-1.6
Time in novel zone, NPP test	2.6	2.7	4.3	-1.7	-2.1	0.9	1.9	-1.4
Total zone transitions, NPP test	2.5	3.6	5.1	0.7	2.2	-1.8	-2.0	2.3
Total locomotion distance, NPP test	2.0	2.7	5.0	-0.1	1.8	-1.2	-2.2	2.0
Locomotion velocity, NPP test	1.3	1.8	3.3	-0.4	1.4	-1.0	-1.8	1.6
Intraocular pressure	0.9	1.3	2.3	-0.8	0.6	-1.5	-1.4	1.0
Delta distance traveled before/after self-admin	1.2	1.3	3.1	1.0	1.7	0.7	-1.2	0.9
Delta ambulatory time before/after self-admin	1.4	1.6	3.5	1.2	1.9	0.9	-1.2	0.8
Parametrial fat weight	1.4	2.8	4.7	-2.2	-1.5	2.1	0.7	-1.5
Pavlov. Cond. lever latency	3.1	3.9	4.8	1.2	2.1	-2.1	-2.2	2.0
Pavlov. Cond. magazine entry latency	2.5	3.2	4.4	-1.4	-2.1	1.5	2.0	-1.9
Pavlov. Cond. change in total contacts	1.9	2.0	2.9	-0.6	-1.4	1.6	1.5	-1.7
Pavlov. Cond. index score	2.9	3.7	4.6	-1.9	-2.1	1.7	2.0	-1.8
Pavlov. Cond. latency score	3.2	4.0	5.0	-1.8	-2.2	1.9	2.1	-2.0
Pavlov. Cond. lever contacts	1.1	1.3	1.7	-0.9	-1.1	1.3	1.1	-1.1
Pavlov. Cond. magazine entry number	3.8	4.8	6.2	1.6	2.5	-2.0	-2.2	2.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	-0.6	0.4	-0.1	-0.6	0.4
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.3	4.5	-1.8	-2.1	1.4	2.0	-1.7
Pavlov. Cond. response bias	3.0	3.6	4.4	-1.4	-2.1	1.8	2.0	-2.1
Pavlov. Cond. lever latency	0.3	0.5	0.7	0.8	-0.2	0.8	0.8	-0.6
Pavlov. Cond. magazine entry latency	2.1	2.4	4.3	1.6	1.7	-0.6	-2.1	1.4
Pavlov. Cond. change in total contacts	1.1	1.6	2.7	0.6	1.2	-1.6	-1.4	1.3
Pavlov. Cond. index score	0.8	1.1	2.5	0.5	1.1	-0.7	-1.6	1.0
Pavlov. Cond. latency score	0.9	1.1	2.5	0.3	1.1	-0.8	-1.6	1.0
Pavlov. Cond. lever contacts	0.5	0.6	0.8	-0.9	0.3	-0.9	-0.9	0.9
Pavlov. Cond. magazine entry number	2.2	2.7	4.5	-1.6	-1.9	0.7	2.1	-1.6
Pavlov. Cond. intertrial magazine entries	0.4	0.6	2.0	-1.4	-0.6	-0.6	0.4	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	2.7	0.6	1.2	-0.7	-1.7	1.1
Pavlov. Cond. response bias	0.5	0.7	1.5	0.0	0.7	-0.7	-1.2	0.9
Time in closed arm before self-admin	0.0	0.1	0.1	0.2	0.1	-0.3	-0.3	-0.1
Time in closed arm after self-admin	0.5	0.5	0.8	0.9	-0.2	0.9	0.8	-0.7
Time in open arm before self-admin	0.4	0.4	1.1	-0.7	-0.5	-0.1	1.0	-0.2
Time in open arm after self-admin	0.0	0.1	0.3	-0.0	0.0	-0.5	0.1	-0.0
Bone: periosteal estimation	1.3	2.6	7.0	-2.4	-0.5	-2.6	-0.2	0.2
Bone: periosteal perimeter	2.1	3.4	7.6	-2.7	-2.1	-1.2	1.5	-1.3
Bone: post-yield work	0.8	1.2	3.3	0.2	1.0	-1.8	-0.7	1.0
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	-0.4	0.4	-0.2	-0.4	0.6
Progressive ratio test 1 breakpoint	0.2	0.2	0.6	-0.8	0.0	-0.1	-0.2	0.4
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	-0.6	-0.2	0.0	-0.1	0.4
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	-0.5	-0.0	0.4	-0.3	0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	-0.5	0.2	0.0	-0.5	0.3
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.3	-0.1
Incentive Sensitization - Responses	0.5	0.5	1.0	-1.0	-0.8	0.7	0.1	-0.5
Incentive Sensitization - Breakpoint	0.4	0.4	0.8	-0.9	-0.8	0.7	0.1	-0.5
Sum of active levers in priming session hrs 5-6	1.0	1.0	2.3	-0.4	-0.9	1.2	0.6	-1.5
Progressive ratio	0.8	0.9	2.2	0.5	0.8	-1.5	-1.1	0.4
Food seeking constrained by brief footshock	0.2	0.3	0.9	0.5	-1.0	0.4	0.4	-0.2
Seeking ratio, punishment vs. effort	0.4	0.5	1.0	-0.2	-1.0	0.9	0.8	0.0
Retroperitoneal fat weight	0.9	3.1	13.6	-3.7	-1.2	-0.3	-0.6	-0.3
Reaction time number correct	3.3	4.7	7.0	0.6	2.5	-2.2	-2.3	2.6
Reaction time mean minus median	0.3	0.4	1.0	0.3	-0.3	1.0	0.2	-1.0
Reaction time mean minus median AUC	0.0	0.0	0.1	0.1	-0.2	0.2	0.0	-0.3
Reaction time num false alarms	0.1	0.1	0.2	-0.1	-0.1	-0.5	0.2	-0.4
Reaction time num false alarms AUC	0.1	0.1	0.3	0.3	0.4	-0.5	-0.1	-0.0
Reaction time trials correct on left	3.3	4.7	7.0	0.6	2.5	-2.2	-2.3	2.6
Reaction time trials on left	3.5	5.0	7.3	0.6	2.5	-2.3	-2.3	2.7
Reaction time mean	0.2	0.3	0.6	-0.8	-0.6	0.4	0.3	-0.6
Reaction time mean AUC	0.1	0.1	0.4	-0.7	0.0	-0.2	-0.1	0.0
Median of all reaction times	0.2	0.2	0.6	-0.8	-0.5	0.1	0.3	-0.3
Reaction time omissions	0.2	0.2	0.4	0.4	0.6	0.2	-0.5	0.5
Reaction time false alarm rate	0.7	0.9	2.0	-0.1	-1.0	0.7	1.1	-1.4
Reaction time premature initiation rate	0.3	0.4	0.8	0.8	0.4	0.9	0.2	-0.3
Reaction time premature initiations	1.1	1.5	3.3	1.0	1.8	-0.5	-1.2	1.3
Std. dev. reaction times	0.1	0.1	0.2	0.4	0.3	0.2	-0.2	-0.1
Reaction time trials completed	3.5	5.0	7.3	0.6	2.5	-2.3	-2.3	2.7
Reaction time trials AUC	3.2	4.6	6.9	0.5	2.4	-2.2	-2.2	2.6
Run reversals in cocaine runway, females	0.7	0.6	2.1	0.3	1.5	-0.6	-0.6	0.5
Run reversals in cocaine runway, males	1.7	1.7	2.2	-1.3	-1.3	1.4	0.8	-1.5
Latency to leave start box in cocaine runway	0.5	0.6	1.6	-0.1	1.0	0.0	-1.3	0.4
Latency to leave start box in cocaine runway, F	1.2	1.3	3.4	-0.2	1.2	-0.7	-1.9	1.2
Latency to leave start box in cocaine runway, M	0.4	0.4	1.1	-0.3	0.4	1.0	0.1	-0.8
Std. dev. time between licks in bursts	3.1	3.7	5.9	0.3	2.1	-1.9	-2.1	2.4
Total sessions with >9 infusions	0.3	0.3	0.9	0.5	0.9	-0.0	-0.6	0.6
Short access day 1 total inactive lever presses	0.2	0.3	0.5	-0.2	0.6	-0.4	-0.7	0.4
Short access day 10 total inactive lever presses	0.7	0.8	1.4	-1.2	-0.9	0.8	0.7	-0.7
Short access day 1 total infusions	0.5	0.6	1.8	1.3	0.4	0.7	0.5	-0.2
Short access day 10 total infusions	0.2	0.3	1.3	-0.2	-0.1	1.1	0.1	-0.1
Short access total infusions	0.4	0.4	2.0	0.2	-0.2	1.4	0.4	-0.2
Short access day 1 locomotion	0.6	0.7	1.5	0.5	-0.7	0.7	1.2	-0.7
Short access day 10 total locomotion	0.8	0.9	2.5	0.8	-0.6	1.6	0.9	-0.5
Short access total locomotion	0.4	0.5	0.9	0.7	-0.5	0.9	0.8	-0.2
One hour access (0.3 mA shock)	0.5	0.5	1.3	-1.2	-0.2	1.1	-0.3	0.0
Compulsive drug intake	0.2	0.2	0.7	-0.8	-0.2	-0.2	-0.3	0.0
One hour access (shock baseline)	0.2	0.3	0.6	-0.6	0.2	0.8	-0.3	0.4
Social response proportion	1.4	1.5	2.6	1.4	1.4	-1.6	-0.4	1.0
Social responses	0.5	0.7	1.0	1.0	0.8	-0.9	0.4	0.9
Social time	0.3	0.4	1.8	0.2	0.4	-1.4	-0.0	0.4
Soleus weight	0.5	1.5	4.4	-2.1	-1.2	0.5	1.0	-0.4
Bone: stiffness	1.0	1.5	3.8	-1.7	-0.3	-1.9	-0.8	0.0
Tibialis anterior weight	0.0	0.2	0.7	-0.9	-0.0	0.1	-0.3	0.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	0.0	0.0	-0.2	-0.7	0.7
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	0.7	0.6	-0.4	-0.1	0.4
Time to tail flick, test, before self-admin	0.7	0.7	1.8	0.7	0.7	0.7	-1.4	0.7
Time to tail flick, test, after self-admin	0.9	0.9	2.5	1.6	1.2	0.3	-0.5	0.6
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.5	-0.1	0.3	0.7	-0.1	-0.1
Delta time to tail flick, test, before/after SA	0.8	0.7	2.1	0.3	-0.2	0.2	1.4	-1.2
Tibia length	5.6	15.9	38.3	-6.2	-5.1	-1.1	2.7	-2.6
Ambulatory time before self-admin	0.4	0.5	1.5	-0.5	-1.2	-0.1	0.7	-0.3
Ambulatory time after self-admin	0.2	0.3	0.5	0.3	0.7	0.4	-0.7	0.4
Bone: tissue strength	1.6	1.5	4.8	-1.0	0.2	-2.2	-0.8	1.0
Total heroin consumption	0.5	0.6	1.7	-0.2	-0.5	-1.3	0.2	-1.0
Bone: trabecular number	0.0	0.1	0.2	-0.1	-0.1	0.4	0.3	-0.1
Bone: trabecular spacing	3.1	4.0	5.7	0.4	1.9	-2.3	-2.4	2.3
Bone: trabecular thickness	3.9	4.7	6.7	-1.2	-2.4	1.8	2.6	-2.5
Bone: trabecular tissue density	0.9	1.3	2.5	1.2	0.8	-1.1	-1.6	0.9
Water consumed over 24 hours	1.0	1.2	2.0	-0.1	-1.2	1.4	1.2	-1.1
Number of responses in last shaping day	0.1	0.1	0.1	-0.4	-0.4	-0.4	0.4	0.1