Mest

mesoderm specific transcript

chr4:60321814–60332288 (+)

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Mest	0.08	0.05	1.4e-03	0.05	0.06	0.04	0.04	1.2e-03	6.6e-04	4.2e-03	2.9e-03
2	RMTg	gene expression	Mest	0.14	0.09	3.5e-03	0.04	0.09	0.04	0.06	4.2e-02	2.4e-03	3.3e-02	1.3e-02
3	Adipose	mRNA stability	Mest	0.03	0.02	6.3e-03	0.01	0.01	0	0.01	7.0e-03	1.1e-02	1.3e-01	5.5e-02
4	Brain	mRNA stability	Mest	0.03	0.02	9.2e-03	0.02	0.03	0.02	0.02	1.0e-02	1.4e-03	4.4e-03	8.3e-03
5	pVTA	mRNA stability	Mest	0.06	0.05	1.5e-03	0.02	0.04	0.04	0.03	4.7e-03	3.3e-04	4.5e-04	2.0e-03
6	Liver	mRNA stability	Mest	0.07	0.04	1.3e-09	0.07	0.09	0.09	0.09	1.7e-08	4.7e-10	4.7e-10	4.2e-10
7	PL	gene expression	Mest	0.1	0.05	1.6e-09	0.08	0.1	0.09	0.09	4.9e-09	1.2e-10	3.7e-10	2.5e-10
8	NAcc	gene expression	Mest	0.04	0.02	5.8e-06	0.03	0.04	0.03	0.03	9.2e-06	3.1e-06	3.2e-05	2.0e-05
9	IC	gene expression	Mest	0.16	0.08	1.9e-05	0.14	0.12	0.12	0.12	1.8e-06	8.7e-06	1.4e-05	8.2e-06
10	Brain	gene expression	Mest	0.17	0.07	5.0e-16	0.14	0.19	0.19	0.18	7.0e-13	1.4e-17	2.7e-17	9.1e-17
11	Adipose	gene expression	Mest	0.5	0.24	1.1e-13	0.11	0.12	0.12	0.13	8.3e-12	1.9e-13	1.1e-13	7.3e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	1.0	1.7	3.5	-0.7	-0.5	-1.1	1.3	1.6	1.2	-1.6	-1.9	-0.8	-1.6	-1.5
Area under the delay curve	1.7	2.0	5.3	2.0	-2.3	-1.3	1.7	1.2	-1.5	0.9	0.4	1.3	1.1	0.2
BMI with tail	0.4	1.4	3.6	-0.1	1.3	1.5	-1.7	-1.9	-0.6	1.0	1.4	0.1	0.8	1.1
BMI without tail	1.2	3.7	8.9	-1.7	2.9	3.0	-3.0	-2.7	0.6	0.3	1.0	-0.8	0.1	1.6
Body weight	1.3	5.8	13.5	-3.0	3.7	3.2	-3.3	-2.7	2.1	-1.0	-0.1	-2.3	-1.2	0.7
Weight adjusted by age	0.8	1.1	2.2	-0.6	-0.2	-0.7	0.7	1.1	1.0	-1.5	-1.5	-1.2	-1.3	-1.3
Bone surface	0.5	0.9	2.4	-1.5	1.0	0.5	-0.3	0.1	1.6	-0.9	-0.9	-1.1	-1.0	-0.2
Bone volume	0.4	0.7	1.3	-0.8	0.3	-0.3	0.4	0.6	1.1	-1.0	-1.1	-1.0	-1.1	-0.9
Breakpoint value in progressive ratio session	0.2	0.2	0.5	-0.4	0.6	0.7	-0.7	-0.5	0.3	0.0	0.2	-0.4	0.1	0.4
Number of licking bursts	2.9	4.7	10.3	3.2	-2.4	-1.6	1.3	0.5	-3.1	2.3	2.0	2.4	2.5	0.8
Context. condit. distance diff. score	0.9	1.1	2.9	-1.3	1.7	0.9	-1.5	-0.9	0.9	-0.8	-0.2	-1.3	-0.8	-0.3
Locomotion velocity, session 1	0.7	0.7	2.8	-0.8	1.1	1.7	-1.0	-1.3	0.4	0.2	0.3	-0.1	0.0	0.7
Locomotion distance, session 1	0.3	0.4	1.2	-0.3	0.2	1.0	-0.5	-0.5	0.2	0.4	0.4	0.6	0.5	1.1
Locomotion velocity, session 2	1.7	1.9	5.7	-1.5	1.9	2.4	-1.8	-1.9	1.0	0.1	0.4	-0.8	-0.1	1.0
Locomotion distance, session 2	0.4	0.6	1.5	-1.2	0.9	1.2	-0.8	-0.7	1.1	-0.4	-0.3	-0.6	-0.3	0.4
Locomotion velocity, session 3	1.7	2.0	4.7	-1.5	2.1	2.1	-2.2	-1.7	1.2	-0.3	0.4	-0.8	-0.2	0.9
Locomotion distance, session 3	1.2	1.3	3.3	-0.8	1.4	1.8	-1.7	-1.6	0.4	0.5	0.9	0.2	0.5	1.3
Stereotopy head waving bouts, day 3	0.4	0.5	1.4	-0.3	1.0	0.6	-1.2	-0.9	0.0	-0.1	0.4	-1.0	0.0	-0.1
Stereotopy head waving duration, day 3	0.3	0.4	1.3	-0.4	0.8	0.5	-1.0	-0.7	0.2	-0.3	0.2	-1.1	-0.0	-0.1
Locomotion velocity, session 7	0.5	0.6	1.4	-1.1	0.5	0.5	-0.2	0.3	1.1	-1.2	-1.0	-0.3	-1.0	-0.2
Locomotion distance, session 7	0.3	0.4	0.9	-0.6	0.9	0.5	-0.8	-0.5	0.5	-0.5	-0.1	-0.9	-0.5	-0.5
Stereotopy head waving bouts, day 7	0.2	0.3	0.9	-0.4	0.7	0.0	-0.6	-0.2	0.5	-0.5	-0.2	-0.9	-0.4	-0.5
Stereotopy head waving duration, day 7	0.3	0.3	1.1	-0.6	0.7	0.0	-0.6	-0.1	0.7	-0.7	-0.3	-1.0	-0.5	-0.5
Locomotion velocity, session 8	2.0	2.4	5.9	-1.1	1.9	2.4	-2.3	-2.2	0.5	0.6	1.1	-0.2	0.6	1.7
Locomotion distance, session 8	0.8	1.2	2.9	-1.1	1.6	1.6	-1.7	-1.4	0.6	0.0	0.5	-0.6	0.0	0.7
Degree of sensitization distance	0.3	0.3	0.7	0.2	-0.5	-0.9	0.7	0.7	-0.1	-0.4	-0.5	-0.3	-0.3	-0.7
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.2	0.2	-0.3	-0.1	0.1	0.5	-0.5	-0.3	-0.6	-0.5	-0.6
Conditioned locomotion	0.8	0.9	1.9	-1.2	1.4	1.4	-1.3	-0.9	0.9	-0.4	0.0	-0.1	-0.4	0.9
Cocaine response after cond. corrected	0.3	0.4	1.2	-0.4	0.9	0.8	-1.1	-0.9	0.1	0.1	0.5	-0.4	0.1	0.3
Cocaine response after cond. not corrected	0.3	0.3	0.9	-0.5	0.9	0.7	-0.9	-0.8	0.1	0.1	0.4	-0.4	0.0	0.2
Cocaine response before conditioning	0.1	0.1	0.3	0.0	0.1	0.3	0.0	-0.2	-0.2	0.5	0.3	0.5	0.3	0.5
Saline control response	0.6	0.8	2.1	-0.9	1.0	1.4	-1.0	-1.0	0.8	0.2	0.3	0.2	0.2	1.3
Bone: connectivity density	1.2	1.9	4.2	-1.1	-0.3	-0.9	1.2	1.7	1.6	-1.7	-2.1	-0.6	-1.7	-1.1
Bone: cortical apparent density	0.2	0.3	0.7	0.4	-0.7	-0.7	0.8	0.6	-0.1	-0.3	-0.5	-0.4	-0.3	-0.9
Bone: cortical area	0.3	0.4	1.3	-0.9	0.7	0.6	-0.3	-0.3	1.1	-0.4	-0.4	-1.0	-0.5	-0.0
Bone: cortical porosity	0.1	0.1	0.4	-0.4	0.4	0.7	-0.2	-0.4	0.4	0.2	0.1	0.0	0.1	0.4
Bone: cortical porosity	0.3	0.3	0.8	-0.3	0.3	0.9	-0.3	-0.6	0.2	0.6	0.4	0.3	0.5	0.8
Bone: cortical thickness	0.3	0.5	2.2	-0.4	0.1	-0.1	0.2	0.2	0.9	-0.7	-0.7	-1.5	-0.7	-1.0
Bone: cortical thickness	0.5	0.6	2.0	0.7	-1.2	-1.0	1.4	1.0	-0.2	-0.2	-0.6	0.1	-0.2	-0.8
Bone: cortical tissue density	0.3	0.4	0.8	0.4	-0.8	-0.8	0.9	0.7	-0.2	-0.3	-0.5	-0.3	-0.3	-0.9
Condit. Reinf. active minus inactive responses	0.2	0.2	0.8	-0.1	-0.0	-0.2	0.4	0.1	0.2	-0.3	-0.4	-0.6	-0.5	-0.9
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.1	0.1	-0.7	-1.0	1.0	1.0	0.3	-0.6	-0.9	-0.5	-0.6	-1.0
Condit. Reinf. active responses	0.1	0.2	0.3	-0.4	0.2	0.3	0.2	-0.1	0.5	-0.5	-0.5	-0.4	-0.6	-0.5
Condit. Reinf. inactive responses	0.3	0.4	1.0	-0.8	0.8	1.0	-0.7	-0.6	0.8	-0.5	-0.2	-0.1	-0.4	0.3
Incentive salience index mean	0.2	0.2	0.4	-0.6	0.6	0.6	-0.2	-0.5	0.5	-0.2	-0.2	-0.6	-0.4	-0.4
Condit. Reinf. lever presses	0.5	0.7	2.3	-1.1	1.1	1.5	-0.9	-0.9	0.9	-0.2	-0.1	-0.4	-0.3	0.5
Condit. Reinf. active minus inactive responses	0.7	0.9	1.6	1.1	-1.3	-1.3	1.2	1.1	-0.8	0.7	0.2	1.2	0.7	-0.0
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.9	-0.2	-0.4	-0.6	0.8	0.9	0.5	-0.1	-0.6	0.4	-0.3	-0.2
Condit. Reinf. active responses	1.5	2.0	3.9	2.0	-1.6	-1.4	1.2	0.8	-1.9	1.5	1.1	1.7	1.4	0.2
Condit. Reinf. inactive responses	1.7	2.2	5.3	2.1	-1.2	-0.8	0.5	-0.0	-2.3	1.8	1.6	1.6	1.7	0.6
Condit. Reinf. lever presses	1.9	2.6	5.1	2.0	-2.1	-2.3	2.0	1.9	-1.6	0.9	0.3	2.0	0.8	-0.2
Condit. Reinf. lever reinforcers received	2.3	3.2	6.0	2.4	-2.2	-1.9	1.7	1.3	-2.2	1.7	1.0	2.2	1.6	0.2
Conditioned reinforcement - actives	0.8	1.4	4.4	1.4	-1.2	-1.9	1.4	1.0	-0.7	-0.1	-0.3	-0.8	-0.2	-2.1
Conditioned reinforcement - inactives	1.7	2.5	5.8	2.0	-2.4	-2.0	2.1	1.7	-1.5	0.8	0.2	1.7	0.9	-0.3
Conditioned locomotion	0.6	0.8	1.9	1.2	-1.0	-1.4	0.9	0.5	-0.8	0.2	0.1	-0.8	0.3	-1.3
Patch foraging indifference point 0 sec	2.5	4.7	11.2	3.4	-2.8	-1.9	2.2	1.0	-3.1	2.0	1.3	2.2	1.8	-0.1
Patch foraging indifference point AUC	2.4	3.5	7.8	1.7	-2.8	-2.5	2.7	2.6	-1.3	0.4	-0.4	2.1	0.6	-0.0
Delay disc. indifference point, 0s delay	1.0	1.0	2.4	1.1	-1.4	-1.5	1.5	1.3	-0.6	0.1	-0.3	0.9	0.1	-0.8
Delay disc. indifference point, 16s delay	1.2	1.3	3.6	1.5	-1.9	-0.6	1.3	0.8	-1.2	0.8	0.4	1.3	1.1	0.8
Delay disc. indifference point, 2s delay	1.0	1.1	2.6	1.5	-1.6	-1.3	1.2	1.1	-1.1	0.3	0.1	1.0	0.5	-0.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.6	0.7	-0.8	-0.4	0.6	0.5	-0.6	0.2	0.1	-0.1	0.3	-0.3
Delay disc. indifference point, 4s delay	1.0	1.1	2.8	1.4	-1.7	-1.0	1.3	1.0	-1.0	0.7	0.3	1.1	0.8	0.1
Delay disc. indifference point, 8s delay	0.6	0.7	2.4	0.9	-1.6	-0.9	1.2	1.2	-0.6	0.1	-0.2	0.7	0.3	0.2
Indifference point function ln k	1.1	1.9	5.7	-0.5	1.9	1.7	-2.1	-2.4	-0.1	0.6	1.2	-1.3	0.4	0.3
Indifference point function log k	1.1	1.9	5.7	-0.5	1.9	1.7	-2.1	-2.4	-0.1	0.6	1.2	-1.3	0.4	0.3
Patch foraging total patch changes 0 sec	2.4	4.4	10.8	3.3	-2.7	-1.9	2.0	1.0	-3.0	1.9	1.3	2.1	1.8	-0.1
Patch foraging total patch changes 12 sec	3.9	5.1	9.5	3.0	-3.1	-2.0	2.4	1.5	-2.8	1.9	1.1	2.8	1.9	0.6
Patch foraging total patch changes 18 sec	2.9	4.5	9.9	2.2	-3.1	-2.7	3.1	2.9	-1.6	0.5	-0.4	2.5	0.5	-0.3
Patch foraging total patch changes 24 sec	1.5	2.6	6.2	1.6	-2.5	-2.1	2.5	2.2	-1.2	0.2	-0.5	1.4	0.3	-0.5
Patch foraging total patch changes 6 sec	2.7	4.2	8.2	2.8	-2.9	-2.2	2.6	1.7	-2.5	1.6	0.7	2.1	1.4	-0.3
Patch foraging time to switch 0 sec	0.1	0.1	0.7	-0.4	0.3	0.8	-0.3	-0.5	0.4	-0.1	-0.1	0.2	-0.2	0.4
Patch foraging water rate 0 sec	0.5	1.0	2.8	1.6	-1.1	-1.2	0.7	0.3	-1.7	1.0	0.8	0.5	0.9	-0.3
Patch foraging water rate 12 sec	0.7	1.4	3.0	0.7	0.8	0.9	-1.4	-1.7	-1.1	1.3	1.7	-0.9	1.2	0.2
Patch foraging water rate 18 sec	0.8	1.2	3.2	0.4	1.1	0.8	-1.5	-1.8	-0.8	0.9	1.5	-1.1	0.8	-0.2
Patch foraging water rate 24 sec	0.2	0.3	0.9	0.5	0.2	0.3	-0.5	-0.7	-0.9	0.6	0.8	0.5	0.5	0.3
Patch foraging water rate 6 sec	0.5	0.8	2.3	0.1	1.0	0.7	-1.5	-1.3	-0.6	0.5	1.1	-0.8	0.6	0.5
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.6	-0.8	0.7	0.6	-0.5	-0.5	0.7	0.1	0.0	-0.5	-0.0	0.3
Distance traveled before self-admin	0.1	0.2	0.4	0.5	-0.2	0.0	-0.2	-0.1	-0.5	0.5	0.6	0.5	0.6	0.5
Distance traveled after self-admin	0.7	0.8	3.3	-0.4	0.5	1.1	-0.8	-0.5	0.1	0.6	0.6	1.5	0.6	1.8
Extensor digitorum longus weight	0.3	1.2	2.9	-0.9	-0.3	-0.9	1.0	1.4	1.1	-1.5	-1.7	0.1	-1.5	-0.6
Bone: elastic displacement	0.8	0.9	2.0	-0.9	-0.1	-0.4	0.7	1.1	1.2	-1.2	-1.4	-0.6	-1.2	-0.8
Bone: elastic work	0.9	1.2	2.9	-0.4	-0.9	-1.0	1.6	1.7	0.9	-1.1	-1.6	0.2	-1.1	-0.7
Bone: endosteal estimation	1.3	2.9	6.8	-2.1	2.6	2.5	-2.5	-2.0	1.6	-0.1	0.4	-0.8	-0.3	1.3
Bone: endosteal perimeter	0.4	0.9	2.1	-1.1	1.5	1.4	-1.2	-1.2	0.7	0.2	0.4	-0.4	-0.0	0.9
Epididymis fat weight	0.1	0.5	1.3	0.5	-0.9	-1.1	1.1	0.9	-0.3	-0.2	-0.5	0.2	-0.3	-0.6
Delta time in closed arm before/after self-admin	1.0	1.0	2.3	-0.7	-0.5	-0.7	1.0	1.3	1.0	-1.2	-1.5	-0.0	-1.2	-0.5
Delta time in open arm before/after self-admin	1.4	1.4	3.5	1.1	-0.6	0.5	-0.0	-0.6	-1.3	1.5	1.4	1.9	1.5	1.4
Diff in mean of infusions in LGA sessions	0.4	0.5	0.9	0.2	0.4	0.8	-0.7	-1.0	-0.3	0.8	1.0	-0.3	0.9	0.6
Delay discount exponential model param	1.7	1.8	5.1	-1.9	2.3	1.3	-1.7	-1.3	1.4	-0.7	-0.3	-1.2	-1.0	-0.2
Extinction: sum of active levers before priming	0.3	0.3	1.1	0.2	-0.5	-0.7	0.8	0.7	-0.1	-0.4	-0.5	-0.2	-0.4	-1.0
Active lever presses in extinction session 6	1.1	1.1	2.8	-0.6	1.1	1.7	-1.4	-1.4	0.1	0.7	0.9	0.4	0.6	1.4
Bone: final force	0.2	0.2	1.3	0.1	-0.5	0.1	0.6	0.3	-0.0	0.4	-0.0	1.1	0.2	0.7
Bone: final moment	0.2	0.3	1.5	0.0	-0.5	0.2	0.6	0.3	0.1	0.4	-0.0	1.2	0.3	0.8
Food consumed during 24 hour testing period	2.8	3.8	6.5	1.8	-0.7	0.7	-0.4	-1.0	-2.3	2.6	2.4	2.5	2.6	2.4
Glucose	0.8	1.3	3.2	-1.4	1.8	0.8	-1.2	-1.0	1.0	-0.6	-0.3	-1.8	-0.9	-0.6
Heart weight	0.6	0.9	2.3	-1.0	1.4	0.5	-1.2	-0.7	0.8	-0.8	-0.2	-1.5	-0.7	-0.5
Delay discount hyperbolic model param	1.7	1.9	5.2	-2.0	2.3	1.3	-1.7	-1.3	1.5	-0.8	-0.4	-1.3	-1.1	-0.2
Intermittent access intake day 1-15 change	0.2	0.5	1.7	-0.3	0.1	-0.5	0.2	0.3	0.5	-0.8	-0.7	-1.3	-0.7	-1.1
Intermittent access intake escalation	0.2	0.5	1.2	0.1	-0.5	-0.9	0.8	0.8	0.2	-0.6	-0.8	-0.6	-0.6	-1.1
Intermittent access intake escalation 2	0.4	0.5	1.5	-0.8	0.5	-0.1	-0.2	0.1	0.8	-0.8	-0.7	-1.2	-0.7	-0.8
Intermitt. access day 1 inactive lever presses	0.2	0.6	1.4	-1.2	1.1	0.8	-0.8	-0.3	1.0	-0.8	-0.5	-0.8	-0.8	-0.1
Intermitt. access day 15 inactive lever presses	0.9	1.9	4.6	-1.3	2.0	2.1	-2.1	-2.0	0.6	0.2	0.7	-0.9	0.1	1.1
Intermitt. access escalation Index	0.4	0.6	1.2	-0.3	-0.1	-0.6	0.5	0.8	0.7	-1.1	-1.0	-0.4	-1.1	-1.0
Intermittent access day 1 total infusions	0.4	0.6	1.7	0.2	-0.8	-1.2	1.0	1.3	0.3	-0.5	-0.7	0.3	-0.3	-0.7
Intermittent access day 15 total infusions	0.9	1.4	3.3	0.2	-1.1	-1.7	1.5	1.8	0.5	-1.0	-1.3	-0.2	-0.8	-1.5
Intermittent access terminal intake (last 3 days)	0.5	0.7	1.6	-0.4	-0.5	-0.9	0.8	1.3	0.8	-0.9	-1.1	-0.1	-0.7	-0.8
Intermittent access total infusions	1.5	1.7	4.6	0.6	-1.7	-2.0	1.9	2.1	0.0	-0.7	-1.1	0.7	-0.5	-1.1
Intermittent access day 1 locomotion	0.6	0.8	2.5	0.8	-0.9	-1.6	1.0	1.2	-0.3	-0.4	-0.5	-0.5	-0.2	-1.4
Intermittent access day 15 total locomotion	0.3	0.6	1.5	0.4	-0.8	-1.2	0.9	0.9	-0.2	-0.4	-0.5	-0.7	-0.3	-1.1
Intermittent access total locomotion	1.3	1.6	3.9	0.3	-1.1	-2.0	1.4	1.8	0.2	-1.1	-1.3	-0.5	-0.9	-1.7
Intermittent access standard deviation	0.5	1.0	1.9	-1.4	0.8	-0.0	-0.3	0.3	1.3	-1.3	-1.2	-1.3	-1.3	-0.8
Left kidney weight	2.7	12.4	28.3	-5.1	3.4	2.1	-2.0	-0.0	5.3	-4.4	-3.5	-3.4	-4.1	-1.1
Right kidney weight	2.5	11.6	23.6	-4.8	3.3	1.4	-1.7	0.3	4.9	-4.4	-3.6	-3.4	-4.2	-1.7
Cocaine induced anxiety	0.7	1.0	2.7	-0.7	1.3	1.6	-1.4	-1.6	0.2	0.5	0.7	-0.6	0.4	0.9
Post-drug Anxiety	2.6	2.8	6.5	-0.9	1.8	2.5	-2.2	-2.5	0.1	1.2	1.5	-0.3	1.0	2.2
Baseline Anxiety	0.2	0.2	1.1	-0.5	0.2	0.6	-0.3	-0.2	0.4	0.1	0.1	0.5	0.2	1.1
Tail length	1.6	6.1	13.0	-3.6	3.3	2.3	-2.4	-1.3	3.1	-2.2	-1.4	-2.9	-2.2	-0.3
Length with tail	1.5	6.6	13.7	-3.7	3.0	2.0	-2.0	-0.9	3.5	-2.7	-2.0	-3.2	-2.6	-0.8
Length without tail	0.2	0.8	1.6	-1.1	0.6	0.3	-0.2	0.0	1.3	-1.2	-1.0	-1.1	-1.0	-0.7
LgA early post infusion interval	0.3	0.4	1.3	1.1	-0.5	-0.4	0.4	-0.3	-1.1	0.8	0.7	0.2	0.6	-0.4
LgA late post infusion interval	1.2	1.4	3.7	0.4	-1.5	-1.6	1.9	1.9	0.0	-0.6	-1.1	1.0	-0.6	-0.6
LgA early loading	0.3	0.6	1.3	-1.1	0.0	-0.2	0.5	1.1	1.1	-0.8	-1.1	0.7	-0.8	0.2
LgA late loading	0.1	0.3	0.6	-0.8	0.3	-0.0	-0.0	0.6	0.6	-0.8	-0.8	0.3	-0.8	-0.1
LgA early average infusions	1.2	1.5	3.5	-1.9	0.6	0.1	0.1	1.0	1.8	-1.7	-1.7	-0.1	-1.6	-0.1
LgA late average infusions	0.4	0.6	1.6	-1.0	1.2	1.1	-1.3	-0.7	0.7	-0.3	0.1	-0.3	-0.2	0.7
LgA early timeout	1.0	1.1	2.9	-1.6	0.4	0.2	0.3	0.7	1.7	-1.3	-1.5	-0.3	-1.3	-0.1
LgA late timeout	0.9	1.1	2.7	-0.8	1.4	1.6	-1.6	-1.5	0.4	0.4	0.8	-0.4	0.4	0.9
LgA early titration	1.1	1.6	4.1	-1.9	0.6	0.2	-0.0	0.9	2.0	-1.7	-1.7	-0.4	-1.5	-0.2
LgA late titration	0.8	1.2	2.5	-1.6	1.6	0.9	-1.1	-0.5	1.3	-1.0	-0.6	-1.1	-1.1	-0.4
LgA total infusion	1.0	1.4	3.9	-2.0	1.5	1.3	-1.3	-0.4	1.7	-1.0	-0.7	-0.5	-0.9	0.7
Times rat made contact with spout	0.6	0.7	1.9	1.2	-0.2	-0.3	-0.1	-0.5	-1.4	1.1	1.2	0.3	1.0	-0.0
Lifetime Intake	1.6	2.0	5.4	0.6	-1.8	-2.1	2.0	2.3	0.1	-0.7	-1.2	1.0	-0.5	-1.1
Liver weight, left	0.7	1.1	2.8	-1.2	1.4	1.2	-1.1	-0.9	1.1	-0.7	-0.3	-1.7	-0.7	-0.5
Liver weight, right	1.0	1.7	3.7	-1.9	1.8	1.6	-1.4	-0.8	1.6	-1.1	-0.7	-1.1	-1.1	0.2
Locomotor activity	1.6	2.4	5.8	1.8	-2.2	-1.1	1.5	1.2	-1.4	1.2	0.7	2.4	1.5	1.3
Locomotor testing distance	0.3	0.6	1.4	0.7	-1.2	-1.0	1.2	1.1	-0.4	0.1	-0.3	0.8	0.1	-0.1
Locomotor testing rearing	0.7	1.3	2.5	-1.3	0.5	-0.3	0.3	0.7	1.5	-1.6	-1.5	-1.1	-1.6	-1.1
Locomotion in novel chamber	0.4	0.6	1.4	0.6	-1.1	-0.9	1.2	1.1	-0.4	-0.1	-0.5	0.9	-0.1	-0.3
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	-0.0	0.2	0.4	-0.3	-0.4	0.0	0.0	0.1	-0.4	-0.0	-0.0
Fecal boli incidents, locomotor time 1	0.1	0.2	0.6	0.0	0.7	0.1	-0.8	-0.6	-0.0	0.4	0.6	-0.2	0.3	-0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.8	0.1	0.4	0.4	-0.3	-0.8	-0.1	0.4	0.4	-0.9	0.2	-0.1
Time >=10cm from walls, locomotor time 1	0.9	0.9	2.1	-1.1	1.4	1.2	-1.4	-1.1	0.5	-0.4	0.0	-1.2	-0.4	0.1
Bouts of movement, locomotor time 1	0.4	0.4	1.0	0.7	-0.9	-1.0	0.9	0.8	-0.3	-0.0	-0.2	0.3	0.0	-0.7
Total resting periods, locomotor time 1	0.9	1.0	2.2	1.5	-1.5	-1.3	1.2	0.9	-1.0	0.6	0.3	1.0	0.7	-0.3
Rest time, locomotor task time 1	2.0	2.5	5.9	2.4	-1.9	-1.5	1.1	0.4	-2.0	1.8	1.4	1.4	1.8	0.3
Distance moved, locomotor task time 1	0.2	0.3	0.7	-0.7	0.3	0.1	0.2	0.2	0.6	-0.7	-0.8	-0.2	-0.8	-0.4
Vertical activity count, locomotor time 1	0.7	1.8	4.2	-1.5	0.2	-0.5	0.9	1.3	1.5	-1.8	-2.1	-0.0	-1.9	-1.1
Time >=10cm from walls, locomotor time 2	0.6	0.9	2.1	1.1	-0.3	0.1	-0.1	-0.6	-1.4	1.4	1.3	0.9	1.3	0.7
Bouts of movement, locomotor time 2	0.1	0.1	0.6	0.2	-0.4	0.1	0.4	0.3	-0.1	0.1	-0.0	0.8	0.1	0.2
Total resting periods, locomotor time 2	0.0	0.1	0.3	-0.1	0.1	0.5	-0.2	-0.1	0.2	0.1	0.1	0.4	0.1	0.4
Rest time, locomotor task time 2	0.5	0.6	1.5	-0.9	0.8	1.2	-1.1	-0.9	0.9	-0.4	0.0	-0.8	-0.1	0.8
Distance moved, locomotor task time 2	3.1	3.7	8.1	2.8	-2.3	-2.2	1.9	0.9	-2.7	1.8	1.2	1.9	1.6	-0.4
Vertical activity count, locomotor time 2	0.8	1.1	3.0	1.5	-0.7	-0.9	0.7	-0.0	-1.7	1.2	0.9	1.2	0.8	-0.5
Light reinforcement 1	0.5	1.2	3.6	0.8	-1.8	-0.7	1.7	1.4	-0.4	0.3	-0.4	1.9	0.4	0.7
Light reinforcement 2	2.5	3.8	9.6	2.0	-3.0	-1.9	2.7	2.3	-1.4	0.7	-0.2	3.1	0.9	0.5
Bone: marrow area	1.3	2.9	6.7	-2.1	2.6	2.4	-2.5	-2.0	1.6	-0.1	0.4	-0.7	-0.2	1.3
Bone: maximum diameter	0.5	0.9	2.5	-1.0	1.0	1.6	-0.9	-1.1	0.8	0.5	0.4	0.1	0.3	1.4
Bone: maximum force	0.1	0.1	0.4	0.2	-0.3	0.2	0.3	-0.0	-0.1	0.5	0.3	0.6	0.4	0.6
Bone: maximum moment	0.1	0.1	0.5	0.0	-0.2	0.2	0.2	0.0	0.1	0.4	0.1	0.6	0.3	0.7
Mean time between licks in bursts	1.8	4.3	9.7	2.1	-3.1	-2.9	3.1	2.8	-1.3	-0.0	-0.8	1.9	0.1	-1.0
Mean num. licks in bursts	2.2	3.4	6.7	-2.6	1.9	0.7	-0.7	-0.1	2.5	-2.1	-1.9	-2.0	-2.4	-1.3
Cd content in liver	0.4	0.5	1.0	-0.4	-0.2	-0.5	0.6	0.6	0.7	-1.0	-1.0	-0.7	-0.9	-0.8
Co content in liver	0.3	0.4	1.0	0.4	-1.0	-0.5	0.9	0.8	-0.3	0.1	-0.2	0.9	0.2	0.4
Cu content in liver	1.0	1.2	4.4	0.3	-0.3	0.9	-0.3	-0.4	-0.5	1.0	0.9	2.1	1.1	2.0
Fe content in liver	0.3	0.4	1.7	0.5	-0.8	0.2	0.4	0.1	-0.3	0.4	0.2	1.3	0.5	0.9
K content in liver	1.1	1.1	2.2	0.9	-0.9	0.0	0.2	-0.1	-1.1	1.2	1.0	1.5	1.5	1.5
Mg content in liver	1.3	1.3	5.0	0.5	-0.6	0.6	-0.1	-0.2	-0.7	1.3	1.0	1.8	1.5	2.2
Mn content in liver	0.4	0.4	1.4	-1.2	0.5	0.8	-0.2	0.1	1.0	-0.4	-0.6	0.2	-0.4	0.7
Na content in liver	2.3	2.5	5.4	0.9	0.7	1.4	-1.7	-2.1	-1.4	1.9	2.3	0.6	1.9	1.5
Rb content in liver	2.6	3.1	7.0	1.9	-2.6	-1.2	1.8	1.4	-1.6	1.3	0.7	2.5	1.7	1.4
Se content in liver	0.2	0.3	1.2	0.3	-0.5	0.1	0.4	0.2	-0.2	0.5	0.2	1.1	0.5	0.8
Sr content in liver	0.2	0.2	0.4	-0.3	0.2	-0.3	-0.0	0.2	0.4	-0.7	-0.5	0.1	-0.6	-0.4
Zn content in liver	1.3	1.5	4.4	0.6	-1.8	-1.1	1.6	1.6	-0.4	0.2	-0.4	2.1	0.5	1.2
Bone: minimum diameter	1.0	1.9	4.7	-2.1	1.6	1.0	-1.1	-0.4	2.2	-1.3	-1.0	-1.7	-1.2	-0.1
Time in familiar zone, hab. session 1	1.4	1.4	3.3	-1.1	1.7	1.7	-1.8	-1.4	0.7	0.4	0.8	0.1	0.4	1.3
Time in novel zone, hab. session 1	1.3	1.3	3.2	1.8	-1.5	-1.7	1.4	0.8	-1.5	0.4	0.2	0.3	0.2	-1.2
Total zone transitions, hab. session 1	0.2	0.2	0.5	0.7	-0.1	-0.0	-0.0	-0.4	-0.7	0.7	0.7	0.2	0.5	-0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.8	0.9	-0.7	-0.4	0.4	0.2	-0.7	0.5	0.4	0.4	0.5	-0.2
Locomotion velocity, hab. session 1	0.2	0.3	0.8	0.9	-0.9	-0.5	0.7	0.4	-0.6	0.4	0.2	0.4	0.4	-0.3
Time in familiar zone, hab. session 2	0.6	0.7	1.7	-1.0	1.3	0.9	-1.3	-0.8	0.7	-0.2	0.2	-1.0	-0.2	0.1
Time in novel zone, hab. session 2	2.6	2.6	5.9	2.0	-2.4	-2.1	2.4	1.6	-1.6	0.5	-0.1	1.6	0.5	-0.7
Total zone transitions, hab. session 2	0.3	0.4	1.0	0.8	-0.3	-0.0	-0.1	-0.3	-0.7	0.9	0.9	-0.0	1.0	0.1
Total locomotion distance, hab. session 2	0.5	0.6	1.6	1.3	-1.0	-0.4	0.5	0.1	-1.1	0.9	0.8	0.4	1.1	0.1
Locomotion velocity, hab. session 2	0.3	0.4	1.0	0.9	-0.7	-0.0	0.2	-0.2	-0.9	0.8	0.8	0.3	1.0	0.3
Novel to familiar place preference ratio	0.5	0.6	1.4	1.0	0.0	-0.2	-0.2	-0.8	-1.0	1.2	1.1	-0.3	0.9	-0.3
Novelty place preference	1.2	1.3	3.2	1.2	0.2	0.3	-0.6	-1.4	-1.4	1.8	1.8	0.0	1.4	0.2
Time in novel zone, NPP test	0.8	0.8	2.1	1.0	0.2	0.0	-0.4	-1.0	-1.2	1.4	1.4	-0.1	1.1	-0.2
Total zone transitions, NPP test	0.0	0.1	0.2	-0.3	0.3	0.4	-0.2	-0.2	0.3	-0.0	-0.0	0.1	-0.1	0.1
Total locomotion distance, NPP test	0.0	0.0	0.1	0.0	-0.1	0.1	-0.1	0.1	0.0	0.1	0.1	0.2	0.3	0.4
Locomotion velocity, NPP test	0.2	0.3	0.8	0.1	0.1	0.6	-0.4	-0.4	-0.2	0.5	0.6	0.3	0.7	0.9
Intraocular pressure	2.2	3.2	8.0	1.6	-0.9	0.4	-0.2	-0.7	-1.8	2.2	2.0	2.8	2.3	2.3
Delta distance traveled before/after self-admin	0.1	0.1	0.5	-0.5	0.0	0.1	0.1	0.3	0.4	-0.3	-0.4	0.7	-0.2	0.5
Delta ambulatory time before/after self-admin	0.3	0.4	1.3	-0.2	-0.6	-0.5	0.7	1.0	0.2	-0.3	-0.6	1.1	-0.2	0.4
Parametrial fat weight	0.7	1.6	3.8	0.4	1.0	1.5	-1.8	-1.9	-0.9	1.1	1.7	-0.2	1.1	1.0
Pavlov. Cond. lever latency	2.5	3.1	9.3	1.3	-2.0	-3.0	2.3	2.5	-0.6	-0.9	-1.2	-0.1	-0.7	-2.1
Pavlov. Cond. magazine entry latency	0.3	0.3	0.7	0.2	0.3	0.6	-0.4	-0.7	-0.5	0.8	0.8	0.5	0.7	0.6
Pavlov. Cond. change in total contacts	0.8	0.8	2.1	0.1	0.8	1.1	-1.1	-1.4	-0.5	1.1	1.2	0.1	0.9	0.8
Pavlov. Cond. index score	1.0	1.3	3.1	-0.4	1.2	1.7	-1.4	-1.8	-0.2	1.0	1.2	0.1	0.8	1.1
Pavlov. Cond. latency score	1.3	1.7	4.4	-0.6	1.4	2.1	-1.6	-1.9	-0.0	1.0	1.2	0.2	0.8	1.5
Pavlov. Cond. lever contacts	1.5	1.8	5.5	-1.0	1.4	2.4	-1.6	-1.8	0.4	0.8	0.9	0.4	0.6	1.8
Pavlov. Cond. magazine entry number	0.6	0.8	1.8	-0.9	-0.1	-0.4	0.5	1.0	1.2	-1.3	-1.3	-0.3	-1.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.9	-1.7	1.1	1.0	-0.4	-0.1	1.6	-1.0	-1.0	0.1	-1.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.4	3.4	-0.4	1.2	1.8	-1.5	-1.8	-0.2	1.1	1.2	0.2	0.8	1.3
Pavlov. Cond. response bias	0.5	0.7	1.5	0.2	0.6	1.0	-0.8	-1.2	-0.6	1.0	1.1	0.2	0.8	0.7
Pavlov. Cond. lever latency	1.6	2.1	6.1	-1.8	2.0	2.5	-1.8	-1.9	1.1	-0.4	-0.0	-1.0	-0.5	0.7
Pavlov. Cond. magazine entry latency	2.7	3.2	10.2	1.6	-2.2	-3.2	2.4	2.6	-0.8	-0.5	-0.9	0.5	-0.4	-1.7
Pavlov. Cond. change in total contacts	1.9	3.0	6.4	2.5	-2.2	-2.5	1.8	1.6	-1.9	1.2	0.7	1.4	1.2	-0.6
Pavlov. Cond. index score	2.3	3.1	9.8	1.6	-2.2	-3.1	2.4	2.6	-0.8	-0.3	-0.7	0.8	-0.1	-1.5
Pavlov. Cond. latency score	2.2	3.0	9.4	1.6	-2.2	-3.1	2.3	2.6	-0.8	-0.2	-0.7	0.8	-0.1	-1.4
Pavlov. Cond. lever contacts	1.5	2.1	6.9	1.5	-1.9	-2.6	1.9	2.1	-0.8	-0.0	-0.4	0.7	0.1	-1.1
Pavlov. Cond. magazine entry number	3.4	4.2	13.1	-2.0	2.6	3.6	-2.8	-2.8	1.1	0.3	0.8	-0.6	0.2	2.0
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.8	-0.8	0.3	0.9	-0.2	-0.2	0.7	-0.2	-0.3	0.4	-0.2	0.7
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.3	10.3	1.8	-2.3	-3.2	2.5	2.6	-1.0	-0.2	-0.7	0.9	-0.1	-1.5
Pavlov. Cond. response bias	2.2	2.9	9.1	2.0	-2.3	-3.0	2.2	2.3	-1.2	0.1	-0.3	0.9	0.2	-1.3
LgA PC1 addiction-like behavior	0.6	1.2	3.3	-1.8	1.5	1.3	-1.2	-0.4	1.6	-0.8	-0.5	-0.2	-0.7	0.8
Time in closed arm before self-admin	0.6	0.8	2.0	1.0	-0.8	-0.2	0.4	0.0	-1.1	1.0	0.8	1.4	1.0	0.7
Time in closed arm after self-admin	1.0	1.0	2.6	-0.1	-1.0	-1.0	1.4	1.6	0.3	-0.9	-1.3	1.2	-0.9	-0.2
Time in open arm before self-admin	1.5	1.6	7.2	-0.8	1.0	-0.4	-0.5	-0.1	1.0	-1.3	-0.8	-2.7	-1.2	-1.9
Time in open arm after self-admin	0.3	0.3	1.8	0.3	0.4	-0.0	-0.6	-0.7	-0.2	0.3	0.6	-1.4	0.3	-0.6
Bone: periosteal estimation	0.8	1.8	3.9	-1.6	1.9	2.0	-1.7	-1.5	1.4	-0.1	0.2	-0.9	-0.2	1.0
Bone: periosteal perimeter	0.7	1.3	2.9	-1.3	1.6	1.7	-1.5	-1.5	1.0	0.1	0.4	-1.0	-0.0	0.8
Bone: post-yield work	1.6	2.4	5.9	1.2	0.6	0.9	-1.4	-1.9	-1.6	2.1	2.4	0.2	1.9	1.1
Progressive ratio test 1 active lever presses	1.8	2.2	5.9	-0.0	-1.3	-2.0	1.8	2.4	0.8	-1.4	-1.8	0.5	-1.2	-1.4
Progressive ratio test 1 breakpoint	2.0	2.4	6.1	-0.1	-1.3	-2.1	1.9	2.5	0.9	-1.5	-1.9	0.3	-1.3	-1.6
Progressive ratio test 1 inactive lever presses	0.7	0.9	1.7	-0.8	0.3	-0.7	0.4	1.0	1.0	-1.2	-1.2	-0.8	-1.2	-1.3
Progressive ratio test 2 active lever presses	1.0	1.1	2.8	0.3	-1.1	-1.7	1.3	1.7	0.3	-0.9	-1.1	0.1	-0.7	-1.2
Progressive ratio test 2 breakpoint	1.0	1.1	2.9	0.2	-1.1	-1.6	1.3	1.7	0.3	-0.9	-1.1	0.2	-0.7	-1.1
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.7	0.5	-0.1	-0.0	-0.2	-0.3	-0.4	0.8	0.8	0.4	0.8	0.5
ShA PR total presses	0.4	0.5	1.2	-0.7	-0.1	-0.5	0.5	1.0	0.6	-1.0	-1.1	0.2	-0.9	-0.3
Incentive Sensitization - Responses	0.1	0.2	0.4	0.5	-0.2	-0.2	-0.2	-0.3	-0.6	0.4	0.6	-0.1	0.6	0.2
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	0.5	-0.1	-0.0	-0.3	-0.4	-0.6	0.5	0.7	0.0	0.7	0.3
LgA PR total presses	1.2	1.3	3.7	-1.9	0.9	0.7	-0.2	0.6	1.8	-1.3	-1.3	0.6	-1.3	0.6
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.6	-0.3	0.7	1.0	-0.9	-1.0	0.1	1.0	0.9	0.4	0.9	1.3
Progressive ratio	2.3	3.5	7.6	-2.3	0.5	-0.0	0.5	1.3	2.7	-2.8	-2.7	-1.0	-2.6	-1.2
Food seeking constrained by brief footshock	1.2	1.5	3.0	-1.4	0.8	-0.3	0.0	0.7	1.5	-1.7	-1.5	-1.1	-1.7	-1.2
Seeking ratio, punishment vs. effort	0.8	1.1	2.9	1.5	-0.1	-0.3	-0.4	-0.9	-1.7	1.5	1.6	-0.2	1.3	-0.1
Retroperitoneal fat weight	0.5	2.2	4.7	1.4	0.0	0.7	-0.9	-1.6	-1.9	2.0	2.2	0.5	2.0	1.3
Reaction time number correct	0.4	0.8	2.3	1.5	-0.7	-0.6	0.5	-0.2	-1.5	1.1	0.9	0.4	0.8	-0.3
Reaction time mean minus median	0.3	0.8	2.7	-1.7	1.0	0.7	-0.4	0.0	1.4	-0.8	-0.9	-0.4	-0.9	0.3
Reaction time mean minus median AUC	0.2	0.4	0.9	-0.7	0.9	0.9	-0.7	-0.8	0.3	0.5	0.4	0.3	0.2	0.9
Reaction time num false alarms	0.7	1.0	2.6	1.4	-1.6	-1.0	1.1	0.8	-1.0	0.5	0.3	1.2	0.8	0.1
Reaction time num false alarms AUC	1.0	1.6	3.9	1.7	-2.0	-1.6	1.6	1.2	-1.2	0.5	0.1	1.3	0.6	-0.4
Reaction time trials correct on left	0.4	0.8	2.3	1.5	-0.7	-0.6	0.5	-0.2	-1.5	1.1	0.9	0.4	0.8	-0.3
Reaction time trials on left	0.4	0.8	2.4	1.5	-0.7	-0.7	0.5	-0.1	-1.5	1.1	0.9	0.4	0.8	-0.4
Reaction time mean	0.1	0.2	0.6	-0.8	0.6	0.3	-0.2	-0.2	0.6	-0.3	-0.4	-0.4	-0.5	-0.2
Reaction time mean AUC	0.1	0.2	0.4	-0.7	0.6	0.4	-0.2	-0.3	0.5	-0.2	-0.2	-0.4	-0.4	-0.2
Median of all reaction times	0.0	0.0	0.2	-0.3	0.2	0.1	0.1	-0.1	0.2	-0.2	-0.2	-0.2	-0.3	-0.4
Reaction time omissions	1.4	2.1	5.7	1.0	-1.8	-2.2	2.4	2.2	-0.4	-0.1	-0.9	0.8	-0.3	-1.2
Reaction time false alarm rate	0.4	0.5	1.5	0.6	-1.2	-0.9	1.0	1.0	-0.2	-0.2	-0.4	0.8	0.1	-0.0
Reaction time premature initiation rate	0.1	0.1	0.5	-0.3	0.2	0.1	0.1	0.0	0.2	-0.4	-0.4	-0.7	-0.5	-0.5
Reaction time premature initiations	0.1	0.2	0.6	0.6	-0.2	-0.2	0.3	-0.2	-0.8	0.3	0.3	-0.4	0.1	-0.6
Std. dev. reaction times	0.2	0.4	1.1	-1.1	1.0	0.6	-0.5	-0.5	0.7	-0.2	-0.3	-0.5	-0.5	0.1
Reaction time trials completed	0.4	0.8	2.4	1.5	-0.7	-0.7	0.5	-0.1	-1.5	1.1	0.9	0.4	0.8	-0.4
Reaction time trials AUC	0.4	0.7	2.0	1.4	-0.7	-0.8	0.6	-0.0	-1.4	0.9	0.7	0.2	0.6	-0.6
Run reversals in cocaine runway, females	0.7	0.7	2.0	1.0	-1.4	-0.6	0.8	0.9	-0.7	0.3	0.2	1.3	0.8	0.6
Run reversals in cocaine runway, males	1.2	1.2	3.3	1.8	-0.7	-1.0	0.3	-0.1	-1.7	1.2	1.3	0.1	1.2	-0.6
Latency to leave start box in cocaine runway	1.7	1.9	4.6	1.2	-0.6	0.7	-0.4	-0.8	-1.4	1.7	1.7	1.4	1.9	2.1
Latency to leave start box in cocaine runway, F	0.9	1.1	2.5	1.0	-0.5	0.5	-0.2	-0.5	-1.1	1.3	1.3	0.9	1.5	1.6
Latency to leave start box in cocaine runway, M	1.2	1.1	2.5	1.0	-0.6	0.3	-0.2	-0.5	-1.1	1.2	1.2	1.3	1.4	1.6
Std. dev. time between licks in bursts	2.0	2.7	6.5	1.9	-2.5	-2.0	2.1	2.0	-1.4	0.6	0.0	2.1	0.9	0.1
Total sessions with >9 infusions	3.5	4.3	11.3	1.0	-2.6	-2.9	3.1	3.4	-0.1	-1.1	-1.8	1.6	-0.9	-1.5
Short access day 1 total inactive lever presses	0.3	0.4	1.6	0.7	-0.8	-0.6	0.6	0.6	-0.6	0.5	0.3	1.3	0.6	0.4
Short access day 10 total inactive lever presses	0.5	1.3	3.6	-1.3	1.6	0.9	-1.3	-1.0	1.1	-0.8	-0.4	-1.9	-0.9	-0.6
Short access day 1 total infusions	1.6	2.2	5.6	0.8	-1.9	-2.0	2.1	2.4	-0.2	-0.6	-1.1	1.7	-0.4	-0.6
Short access day 10 total infusions	0.8	1.0	3.0	0.3	-1.1	-1.4	1.4	1.7	0.1	-0.6	-0.9	0.7	-0.5	-0.8
Short access total infusions	1.5	1.9	5.2	0.6	-1.7	-1.9	2.0	2.3	0.0	-0.6	-1.1	1.5	-0.5	-0.7
ShA early post infusion interval	1.4	1.3	2.9	1.5	-0.4	0.1	-0.1	-1.1	-1.6	1.7	1.6	0.0	1.6	0.3
ShA late post infusion interval	1.5	1.5	4.1	2.0	-1.3	-0.7	0.7	-0.1	-1.9	1.5	1.3	0.7	1.5	0.1
ShA early loading	1.4	1.4	3.5	-1.3	0.3	-0.3	0.6	1.2	1.2	-1.7	-1.8	0.2	-1.9	-0.8
ShA late loading	2.1	2.9	6.7	-1.5	-0.5	-1.1	1.5	2.4	1.7	-2.2	-2.6	0.5	-2.1	-0.9
Short access day 1 locomotion	2.6	3.2	7.9	1.0	-1.7	-2.7	2.2	2.3	-0.2	-1.3	-1.5	-0.6	-1.2	-2.8
Short access day 10 total locomotion	0.4	0.7	2.2	0.9	-1.0	-1.5	0.9	1.0	-0.6	-0.2	-0.3	-0.2	-0.0	-1.0
Short access total locomotion	1.2	1.5	4.1	1.0	-1.4	-2.0	1.6	1.7	-0.4	-0.5	-0.8	0.1	-0.5	-1.5
ShA early average infusions	1.3	1.5	3.3	-1.7	0.7	0.0	0.2	1.0	1.6	-1.7	-1.8	-0.2	-1.8	-0.7
ShA late average infusions	3.9	4.1	9.6	-2.1	0.1	-0.9	1.1	2.2	2.4	-3.0	-3.1	-0.4	-2.8	-1.3
ShA early timeout	1.0	1.0	2.2	-1.4	0.5	-0.1	0.3	0.9	1.2	-1.4	-1.5	0.1	-1.5	-0.5
ShA late timeout	5.0	5.4	10.6	-3.1	1.4	0.2	0.0	1.1	3.2	-3.3	-3.1	-2.0	-3.2	-1.5
ShA early titration	1.4	1.6	3.4	-1.8	1.0	0.2	-0.1	0.6	1.7	-1.6	-1.6	-0.8	-1.8	-0.9
ShA late titration	3.6	3.8	7.8	-2.7	0.9	0.0	0.3	1.4	2.7	-2.8	-2.8	-0.8	-2.8	-1.1
ShA total infusions	2.6	3.2	7.5	-1.8	-0.1	-0.9	1.2	2.2	1.9	-2.5	-2.7	0.2	-2.4	-1.1
One hour access (0.3 mA shock)	2.2	2.5	7.0	-0.0	-0.8	-2.1	1.6	1.8	0.8	-1.5	-1.7	-1.2	-1.5	-2.6
Shock compulsivity	0.1	0.2	0.4	-0.6	0.5	0.3	-0.5	0.0	0.4	-0.6	-0.3	-0.2	-0.4	-0.0
Compulsive drug intake	0.6	0.8	1.8	-0.0	-1.0	-0.7	1.3	1.3	0.0	-0.5	-1.0	1.4	-0.5	0.0
One hour access (shock baseline)	0.8	1.2	3.8	-0.5	0.4	-0.7	0.0	0.5	1.1	-1.2	-0.9	-2.0	-1.0	-1.9
Social response proportion	0.4	0.5	1.2	1.0	-0.8	-0.8	0.8	0.4	-1.1	0.6	0.3	0.7	0.4	-0.4
Social responses	0.1	0.2	0.7	0.3	-0.3	-0.2	0.5	0.1	-0.5	0.6	0.2	0.8	0.3	0.2
Social time	0.4	0.5	1.2	-0.3	-0.2	-0.7	0.8	0.9	0.4	-0.8	-1.0	0.0	-0.9	-1.1
Soleus weight	0.2	0.6	1.5	-1.2	1.1	0.7	-0.7	-0.4	1.1	-0.8	-0.6	-0.5	-0.9	0.0
Bone: stiffness	0.2	0.4	1.1	-0.0	0.3	0.9	-0.4	-0.7	-0.1	0.8	0.6	0.7	0.6	1.1
Tibialis anterior weight	0.4	1.2	2.9	-1.7	1.2	0.5	-0.6	0.0	1.6	-1.4	-1.2	-0.7	-1.5	-0.3
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.7	-0.5	0.7	0.2	-0.9	-0.3	0.5	-0.7	-0.2	-1.3	-0.5	0.1
Time to tail flick, vehicle, after self-admin	1.2	1.6	3.7	1.3	-0.1	0.4	-0.9	-1.2	-1.5	1.7	1.9	0.5	1.8	1.2
Time to tail flick, test, before self-admin	0.4	0.5	1.1	0.8	-0.2	0.0	-0.3	-0.6	-1.0	0.8	1.0	0.4	0.9	0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.6	-0.0	0.4	-0.0	-0.5	-0.4	0.1	-0.1	0.2	-0.8	0.0	-0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.9	0.8	-0.3	0.1	-0.0	-0.3	-0.9	0.9	0.9	0.7	0.9	0.2
Delta time to tail flick, test, before/after SA	0.8	0.8	1.8	-1.1	0.8	0.0	-0.2	0.1	1.3	-1.0	-0.9	-1.3	-1.1	-0.8
Tibia length	3.0	8.3	17.5	-0.2	1.8	4.0	-3.1	-3.6	-0.8	3.0	3.3	1.5	3.0	4.2
Ambulatory time before self-admin	0.1	0.1	0.3	0.6	-0.4	-0.3	0.2	0.2	-0.6	0.3	0.3	0.5	0.3	-0.0
Ambulatory time after self-admin	0.4	0.5	2.7	0.2	-0.2	0.2	-0.1	0.1	-0.4	0.5	0.4	1.6	0.5	1.2
Bone: tissue strength	1.2	1.2	5.1	0.9	-1.3	-0.3	0.9	0.7	-0.9	0.8	0.4	2.3	0.9	1.2
Total heroin consumption	1.0	1.1	2.5	-1.0	1.5	1.5	-1.6	-1.5	0.6	0.5	0.7	-0.6	0.4	0.8
Total infusions	1.2	1.6	4.6	-2.1	1.5	1.2	-1.1	-0.1	1.8	-1.3	-1.0	-0.3	-1.2	0.6
Bone: trabecular number	1.0	1.7	3.7	-0.6	-0.8	-1.2	1.6	1.9	1.1	-1.5	-1.9	0.0	-1.5	-1.0
Bone: trabecular spacing	0.3	0.5	0.9	0.9	-0.2	0.1	-0.2	-0.6	-0.9	0.9	0.9	0.6	0.9	0.5
Bone: trabecular thickness	0.1	0.2	0.4	-0.6	0.6	0.5	-0.4	-0.2	0.6	-0.2	-0.2	-0.5	-0.3	-0.1
Bone: trabecular tissue density	0.5	0.7	1.9	0.5	0.7	0.6	-1.0	-1.4	-0.6	0.8	1.1	-0.9	0.7	-0.1
Water consumed over 24 hours	3.1	4.2	8.6	2.1	-0.3	0.8	-0.9	-1.7	-2.6	2.8	2.9	1.6	2.7	1.9
Number of responses in last shaping day	1.1	1.2	2.6	0.0	-1.1	-1.1	1.6	1.6	0.4	-1.0	-1.4	0.4	-1.1	-1.1