Hub : Genes

Mest

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Mest 0.14 0.09 3.5e-03 0.04 0.09 0.04 0.06 4.2e-02 2.4e-03 3.3e-02 1.3e-02
2 Adipose mRNA stability Mest 0.03 0.02 6.3e-03 0.01 0.01 0 0.01 7.0e-03 1.1e-02 1.3e-01 5.5e-02
3 Brain mRNA stability Mest 0.03 0.02 9.2e-03 0.02 0.03 0.02 0.02 1.0e-02 1.4e-03 4.4e-03 8.3e-03
4 BLA gene expression Mest 0.08 0.05 1.4e-03 0.05 0.06 0.04 0.04 1.2e-03 6.6e-04 4.2e-03 2.9e-03
5 pVTA mRNA stability Mest 0.06 0.05 1.5e-03 0.02 0.04 0.04 0.03 4.7e-03 3.3e-04 4.5e-04 2.0e-03
6 Liver mRNA stability Mest 0.07 0.04 1.3e-09 0.07 0.09 0.09 0.09 1.7e-08 4.7e-10 4.7e-10 4.2e-10
7 IC gene expression Mest 0.16 0.08 1.9e-05 0.14 0.12 0.12 0.12 1.8e-06 8.7e-06 1.4e-05 8.2e-06
8 PL gene expression Mest 0.1 0.05 1.6e-09 0.08 0.1 0.09 0.09 4.9e-09 1.2e-10 3.7e-10 2.5e-10
9 NAcc gene expression Mest 0.04 0.02 5.8e-06 0.03 0.04 0.03 0.03 9.2e-06 3.1e-06 3.2e-05 2.0e-05
10 Brain gene expression Mest 0.17 0.07 5.0e-16 0.14 0.19 0.19 0.18 7.0e-13 1.4e-17 2.7e-17 9.1e-17
11 Adipose gene expression Mest 0.5 0.24 1.1e-13 0.11 0.12 0.12 0.13 8.3e-12 1.9e-13 1.1e-13 7.3e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.01.73.5-0.5-1.11.3-0.71.61.2-0.8-1.6-1.9-1.6-1.5
Area under the delay curve1.72.05.3-2.3-1.31.72.01.2-1.51.30.90.41.10.2
BMI with tail0.41.43.61.31.5-1.7-0.1-1.9-0.60.11.01.40.81.1
BMI without tail1.23.78.92.93.0-3.0-1.7-2.70.6-0.80.31.00.11.6
Body weight1.35.813.53.73.2-3.3-3.0-2.72.1-2.3-1.0-0.1-1.20.7
Weight adjusted by age0.81.12.2-0.2-0.70.7-0.61.11.0-1.2-1.5-1.5-1.3-1.3
Bone surface0.50.92.41.00.5-0.3-1.50.11.6-1.1-0.9-0.9-1.0-0.2
Bone volume0.40.71.30.3-0.30.4-0.80.61.1-1.0-1.0-1.1-1.1-0.9
Breakpoint value in progressive ratio session0.20.20.50.60.7-0.7-0.4-0.50.3-0.40.00.20.10.4
Number of licking bursts2.94.710.3-2.4-1.61.33.20.5-3.12.42.32.02.50.8
Context. condit. distance diff. score0.91.12.91.70.9-1.5-1.3-0.90.9-1.3-0.8-0.2-0.8-0.3
Locomotion velocity, session 10.70.72.81.11.7-1.0-0.8-1.30.4-0.10.20.30.00.7
Locomotion distance, session 10.30.41.20.21.0-0.5-0.3-0.50.20.60.40.40.51.1
Locomotion velocity, session 21.71.95.71.92.4-1.8-1.5-1.91.0-0.80.10.4-0.11.0
Locomotion distance, session 20.40.61.50.91.2-0.8-1.2-0.71.1-0.6-0.4-0.3-0.30.4
Locomotion velocity, session 31.72.04.72.12.1-2.2-1.5-1.71.2-0.8-0.30.4-0.20.9
Locomotion distance, session 31.21.33.31.41.8-1.7-0.8-1.60.40.20.50.90.51.3
Stereotopy head waving bouts, day 30.40.51.41.00.6-1.2-0.3-0.90.0-1.0-0.10.40.0-0.1
Stereotopy head waving duration, day 30.30.41.30.80.5-1.0-0.4-0.70.2-1.1-0.30.2-0.0-0.1
Locomotion velocity, session 70.50.61.40.50.5-0.2-1.10.31.1-0.3-1.2-1.0-1.0-0.2
Locomotion distance, session 70.30.40.90.90.5-0.8-0.6-0.50.5-0.9-0.5-0.1-0.5-0.5
Stereotopy head waving bouts, day 70.20.30.90.70.0-0.6-0.4-0.20.5-0.9-0.5-0.2-0.4-0.5
Stereotopy head waving duration, day 70.30.31.10.70.0-0.6-0.6-0.10.7-1.0-0.7-0.3-0.5-0.5
Locomotion velocity, session 82.02.45.91.92.4-2.3-1.1-2.20.5-0.20.61.10.61.7
Locomotion distance, session 80.81.22.91.61.6-1.7-1.1-1.40.6-0.60.00.50.00.7
Degree of sensitization distance0.30.30.7-0.5-0.90.70.20.7-0.1-0.3-0.4-0.5-0.3-0.7
Degree of sensitization stereotypy0.20.20.40.2-0.3-0.1-0.20.10.5-0.6-0.5-0.3-0.5-0.6
Conditioned locomotion0.80.91.91.41.4-1.3-1.2-0.90.9-0.1-0.40.0-0.40.9
Cocaine response after cond. corrected0.30.41.20.90.8-1.1-0.4-0.90.1-0.40.10.50.10.3
Cocaine response after cond. not corrected0.30.30.90.90.7-0.9-0.5-0.80.1-0.40.10.40.00.2
Cocaine response before conditioning0.10.10.30.10.30.00.0-0.2-0.20.50.50.30.30.5
Saline control response0.60.82.11.01.4-1.0-0.9-1.00.80.20.20.30.21.3
Bone: connectivity density1.21.94.2-0.3-0.91.2-1.11.71.6-0.6-1.7-2.1-1.7-1.1
Bone: cortical apparent density0.20.30.7-0.7-0.70.80.40.6-0.1-0.4-0.3-0.5-0.3-0.9
Bone: cortical area0.30.41.30.70.6-0.3-0.9-0.31.1-1.0-0.4-0.4-0.5-0.0
Bone: cortical porosity0.10.10.40.40.7-0.2-0.4-0.40.40.00.20.10.10.4
Bone: cortical porosity0.30.30.80.30.9-0.3-0.3-0.60.20.30.60.40.50.8
Bone: cortical thickness0.30.52.20.1-0.10.2-0.40.20.9-1.5-0.7-0.7-0.7-1.0
Bone: cortical thickness0.50.62.0-1.2-1.01.40.71.0-0.20.1-0.2-0.6-0.2-0.8
Bone: cortical tissue density0.30.40.8-0.8-0.80.90.40.7-0.2-0.3-0.3-0.5-0.3-0.9
Condit. Reinf. active minus inactive responses0.20.20.8-0.0-0.20.4-0.10.10.2-0.6-0.3-0.4-0.5-0.9
Condit. Reinf. active-inactive response ratio0.50.61.1-0.7-1.01.00.11.00.3-0.5-0.6-0.9-0.6-1.0
Condit. Reinf. active responses0.10.20.30.20.30.2-0.4-0.10.5-0.4-0.5-0.5-0.6-0.5
Condit. Reinf. inactive responses0.30.41.00.81.0-0.7-0.8-0.60.8-0.1-0.5-0.2-0.40.3
Incentive salience index mean0.20.20.40.60.6-0.2-0.6-0.50.5-0.6-0.2-0.2-0.4-0.4
Condit. Reinf. lever presses0.50.72.31.11.5-0.9-1.1-0.90.9-0.4-0.2-0.1-0.30.5
Condit. Reinf. active minus inactive responses0.70.91.6-1.3-1.31.21.11.1-0.81.20.70.20.7-0.0
Condit. Reinf. active-inactive response ratio0.20.30.9-0.4-0.60.8-0.20.90.50.4-0.1-0.6-0.3-0.2
Condit. Reinf. active responses1.52.03.9-1.6-1.41.22.00.8-1.91.71.51.11.40.2
Condit. Reinf. inactive responses1.72.25.3-1.2-0.80.52.1-0.0-2.31.61.81.61.70.6
Condit. Reinf. lever presses1.92.65.1-2.1-2.32.02.01.9-1.62.00.90.30.8-0.2
Condit. Reinf. lever reinforcers received2.33.26.0-2.2-1.91.72.41.3-2.22.21.71.01.60.2
Conditioned reinforcement - actives0.81.44.4-1.2-1.91.41.41.0-0.7-0.8-0.1-0.3-0.2-2.1
Conditioned reinforcement - inactives1.72.55.8-2.4-2.02.12.01.7-1.51.70.80.20.9-0.3
Conditioned locomotion0.60.81.9-1.0-1.40.91.20.5-0.8-0.80.20.10.3-1.3
Patch foraging indifference point 0 sec2.54.711.2-2.8-1.92.23.41.0-3.12.22.01.31.8-0.1
Patch foraging indifference point AUC2.43.57.8-2.8-2.52.71.72.6-1.32.10.4-0.40.6-0.0
Delay disc. indifference point, 0s delay1.01.02.4-1.4-1.51.51.11.3-0.60.90.1-0.30.1-0.8
Delay disc. indifference point, 16s delay1.21.33.6-1.9-0.61.31.50.8-1.21.30.80.41.10.8
Delay disc. indifference point, 2s delay1.01.12.6-1.6-1.31.21.51.1-1.11.00.30.10.5-0.2
Delay disc. indifference point, 24s delay0.20.20.6-0.8-0.40.60.70.5-0.6-0.10.20.10.3-0.3
Delay disc. indifference point, 4s delay1.01.12.8-1.7-1.01.31.41.0-1.01.10.70.30.80.1
Delay disc. indifference point, 8s delay0.60.72.4-1.6-0.91.20.91.2-0.60.70.1-0.20.30.2
Indifference point function ln k1.11.95.71.91.7-2.1-0.5-2.4-0.1-1.30.61.20.40.3
Indifference point function log k1.11.95.71.91.7-2.1-0.5-2.4-0.1-1.30.61.20.40.3
Patch foraging total patch changes 0 sec2.44.410.8-2.7-1.92.03.31.0-3.02.11.91.31.8-0.1
Patch foraging total patch changes 12 sec3.95.19.5-3.1-2.02.43.01.5-2.82.81.91.11.90.6
Patch foraging total patch changes 18 sec2.94.59.9-3.1-2.73.12.22.9-1.62.50.5-0.40.5-0.3
Patch foraging total patch changes 24 sec1.52.66.2-2.5-2.12.51.62.2-1.21.40.2-0.50.3-0.5
Patch foraging total patch changes 6 sec2.74.28.2-2.9-2.22.62.81.7-2.52.11.60.71.4-0.3
Patch foraging time to switch 0 sec0.10.10.70.30.8-0.3-0.4-0.50.40.2-0.1-0.1-0.20.4
Patch foraging water rate 0 sec0.51.02.8-1.1-1.20.71.60.3-1.70.51.00.80.9-0.3
Patch foraging water rate 12 sec0.71.43.00.80.9-1.40.7-1.7-1.1-0.91.31.71.20.2
Patch foraging water rate 18 sec0.81.23.21.10.8-1.50.4-1.8-0.8-1.10.91.50.8-0.2
Patch foraging water rate 24 sec0.20.30.90.20.3-0.50.5-0.7-0.90.50.60.80.50.3
Patch foraging water rate 6 sec0.50.82.31.00.7-1.50.1-1.3-0.6-0.80.51.10.60.5
Seeking ratio, delayed vs. immediate footshock0.20.30.60.70.6-0.5-0.8-0.50.7-0.50.10.0-0.00.3
Distance traveled before self-admin0.10.20.4-0.20.0-0.20.5-0.1-0.50.50.50.60.60.5
Distance traveled after self-admin0.70.83.30.51.1-0.8-0.4-0.50.11.50.60.60.61.8
Extensor digitorum longus weight0.31.22.9-0.3-0.91.0-0.91.41.10.1-1.5-1.7-1.5-0.6
Bone: elastic displacement0.80.92.0-0.1-0.40.7-0.91.11.2-0.6-1.2-1.4-1.2-0.8
Bone: elastic work0.91.22.9-0.9-1.01.6-0.41.70.90.2-1.1-1.6-1.1-0.7
Bone: endosteal estimation1.32.96.82.62.5-2.5-2.1-2.01.6-0.8-0.10.4-0.31.3
Bone: endosteal perimeter0.40.92.11.51.4-1.2-1.1-1.20.7-0.40.20.4-0.00.9
Epididymis fat weight0.10.51.3-0.9-1.11.10.50.9-0.30.2-0.2-0.5-0.3-0.6
Delta time in closed arm before/after self-admin1.01.02.3-0.5-0.71.0-0.71.31.0-0.0-1.2-1.5-1.2-0.5
Delta time in open arm before/after self-admin1.41.43.5-0.60.5-0.01.1-0.6-1.31.91.51.41.51.4
Diff in mean of infusions in LGA sessions0.40.50.90.40.8-0.70.2-1.0-0.3-0.30.81.00.90.6
Delay discount exponential model param1.71.85.12.31.3-1.7-1.9-1.31.4-1.2-0.7-0.3-1.0-0.2
Extinction: sum of active levers before priming0.30.31.1-0.5-0.70.80.20.7-0.1-0.2-0.4-0.5-0.4-1.0
Active lever presses in extinction session 61.11.12.81.11.7-1.4-0.6-1.40.10.40.70.90.61.4
Bone: final force0.20.21.3-0.50.10.60.10.3-0.01.10.4-0.00.20.7
Bone: final moment0.20.31.5-0.50.20.60.00.30.11.20.4-0.00.30.8
Food consumed during 24 hour testing period2.83.86.5-0.70.7-0.41.8-1.0-2.32.52.62.42.62.4
Glucose0.81.33.21.80.8-1.2-1.4-1.01.0-1.8-0.6-0.3-0.9-0.6
Heart weight0.60.92.31.40.5-1.2-1.0-0.70.8-1.5-0.8-0.2-0.7-0.5
Delay discount hyperbolic model param1.71.95.22.31.3-1.7-2.0-1.31.5-1.3-0.8-0.4-1.1-0.2
Intermittent access intake day 1-15 change0.20.51.70.1-0.50.2-0.30.30.5-1.3-0.8-0.7-0.7-1.1
Intermittent access intake escalation0.20.51.2-0.5-0.90.80.10.80.2-0.6-0.6-0.8-0.6-1.1
Intermittent access intake escalation 20.40.51.50.5-0.1-0.2-0.80.10.8-1.2-0.8-0.7-0.7-0.8
Intermitt. access day 1 inactive lever presses0.20.61.41.10.8-0.8-1.2-0.31.0-0.8-0.8-0.5-0.8-0.1
Intermitt. access day 15 inactive lever presses0.91.94.62.02.1-2.1-1.3-2.00.6-0.90.20.70.11.1
Intermitt. access escalation Index0.40.61.2-0.1-0.60.5-0.30.80.7-0.4-1.1-1.0-1.1-1.0
Intermittent access day 1 total infusions0.40.61.7-0.8-1.21.00.21.30.30.3-0.5-0.7-0.3-0.7
Intermittent access day 15 total infusions0.91.43.3-1.1-1.71.50.21.80.5-0.2-1.0-1.3-0.8-1.5
Intermittent access terminal intake (last 3 days)0.50.71.6-0.5-0.90.8-0.41.30.8-0.1-0.9-1.1-0.7-0.8
Intermittent access total infusions1.51.74.6-1.7-2.01.90.62.10.00.7-0.7-1.1-0.5-1.1
Intermittent access day 1 locomotion0.60.82.5-0.9-1.61.00.81.2-0.3-0.5-0.4-0.5-0.2-1.4
Intermittent access day 15 total locomotion0.30.61.5-0.8-1.20.90.40.9-0.2-0.7-0.4-0.5-0.3-1.1
Intermittent access total locomotion1.31.63.9-1.1-2.01.40.31.80.2-0.5-1.1-1.3-0.9-1.7
Intermittent access standard deviation0.51.01.90.8-0.0-0.3-1.40.31.3-1.3-1.3-1.2-1.3-0.8
Left kidney weight2.712.428.33.42.1-2.0-5.1-0.05.3-3.4-4.4-3.5-4.1-1.1
Right kidney weight2.511.623.63.31.4-1.7-4.80.34.9-3.4-4.4-3.6-4.2-1.7
Cocaine induced anxiety0.71.02.71.31.6-1.4-0.7-1.60.2-0.60.50.70.40.9
Post-drug Anxiety2.62.86.51.82.5-2.2-0.9-2.50.1-0.31.21.51.02.2
Baseline Anxiety0.20.21.10.20.6-0.3-0.5-0.20.40.50.10.10.21.1
Tail length1.66.113.03.32.3-2.4-3.6-1.33.1-2.9-2.2-1.4-2.2-0.3
Length with tail1.56.613.73.02.0-2.0-3.7-0.93.5-3.2-2.7-2.0-2.6-0.8
Length without tail0.20.81.60.60.3-0.2-1.10.01.3-1.1-1.2-1.0-1.0-0.7
Times rat made contact with spout0.60.71.9-0.2-0.3-0.11.2-0.5-1.40.31.11.21.0-0.0
Lifetime Intake1.62.05.4-1.8-2.12.00.62.30.11.0-0.7-1.2-0.5-1.1
Liver weight, left0.71.12.81.41.2-1.1-1.2-0.91.1-1.7-0.7-0.3-0.7-0.5
Liver weight, right1.01.73.71.81.6-1.4-1.9-0.81.6-1.1-1.1-0.7-1.10.2
Locomotor activity1.62.45.8-2.2-1.11.51.81.2-1.42.41.20.71.51.3
Locomotor testing distance0.30.61.4-1.2-1.01.20.71.1-0.40.80.1-0.30.1-0.1
Locomotor testing rearing0.71.32.50.5-0.30.3-1.30.71.5-1.1-1.6-1.5-1.6-1.1
Locomotion in novel chamber0.40.61.4-1.1-0.91.20.61.1-0.40.9-0.1-0.5-0.1-0.3
Locomotion in novel chamber post-restriction0.00.10.20.20.4-0.3-0.0-0.40.0-0.40.00.1-0.0-0.0
Fecal boli incidents, locomotor time 10.10.20.60.70.1-0.80.0-0.6-0.0-0.20.40.60.3-0.2
Change in fecal boli incidents, locomotor task0.20.20.80.40.4-0.30.1-0.8-0.1-0.90.40.40.2-0.1
Time >=10cm from walls, locomotor time 10.90.92.11.41.2-1.4-1.1-1.10.5-1.2-0.40.0-0.40.1
Bouts of movement, locomotor time 10.40.41.0-0.9-1.00.90.70.8-0.30.3-0.0-0.20.0-0.7
Total resting periods, locomotor time 10.91.02.2-1.5-1.31.21.50.9-1.01.00.60.30.7-0.3
Rest time, locomotor task time 12.02.55.9-1.9-1.51.12.40.4-2.01.41.81.41.80.3
Distance moved, locomotor task time 10.20.30.70.30.10.2-0.70.20.6-0.2-0.7-0.8-0.8-0.4
Vertical activity count, locomotor time 10.71.84.20.2-0.50.9-1.51.31.5-0.0-1.8-2.1-1.9-1.1
Time >=10cm from walls, locomotor time 20.60.92.1-0.30.1-0.11.1-0.6-1.40.91.41.31.30.7
Bouts of movement, locomotor time 20.10.10.6-0.40.10.40.20.3-0.10.80.1-0.00.10.2
Total resting periods, locomotor time 20.00.10.30.10.5-0.2-0.1-0.10.20.40.10.10.10.4
Rest time, locomotor task time 20.50.61.50.81.2-1.1-0.9-0.90.9-0.8-0.40.0-0.10.8
Distance moved, locomotor task time 23.13.78.1-2.3-2.21.92.80.9-2.71.91.81.21.6-0.4
Vertical activity count, locomotor time 20.81.13.0-0.7-0.90.71.5-0.0-1.71.21.20.90.8-0.5
Light reinforcement 10.51.23.6-1.8-0.71.70.81.4-0.41.90.3-0.40.40.7
Light reinforcement 22.53.89.6-3.0-1.92.72.02.3-1.43.10.7-0.20.90.5
Bone: marrow area1.32.96.72.62.4-2.5-2.1-2.01.6-0.7-0.10.4-0.21.3
Bone: maximum diameter0.50.92.51.01.6-0.9-1.0-1.10.80.10.50.40.31.4
Bone: maximum force0.10.10.4-0.30.20.30.2-0.0-0.10.60.50.30.40.6
Bone: maximum moment0.10.10.5-0.20.20.20.00.00.10.60.40.10.30.7
Mean time between licks in bursts1.84.39.7-3.1-2.93.12.12.8-1.31.9-0.0-0.80.1-1.0
Mean num. licks in bursts2.23.46.71.90.7-0.7-2.6-0.12.5-2.0-2.1-1.9-2.4-1.3
Cd content in liver0.40.51.0-0.2-0.50.6-0.40.60.7-0.7-1.0-1.0-0.9-0.8
Co content in liver0.30.41.0-1.0-0.50.90.40.8-0.30.90.1-0.20.20.4
Cu content in liver1.01.24.4-0.30.9-0.30.3-0.4-0.52.11.00.91.12.0
Fe content in liver0.30.41.7-0.80.20.40.50.1-0.31.30.40.20.50.9
K content in liver1.11.12.2-0.90.00.20.9-0.1-1.11.51.21.01.51.5
Mg content in liver1.31.35.0-0.60.6-0.10.5-0.2-0.71.81.31.01.52.2
Mn content in liver0.40.41.40.50.8-0.2-1.20.11.00.2-0.4-0.6-0.40.7
Na content in liver2.32.55.40.71.4-1.70.9-2.1-1.40.61.92.31.91.5
Rb content in liver2.63.17.0-2.6-1.21.81.91.4-1.62.51.30.71.71.4
Se content in liver0.20.31.2-0.50.10.40.30.2-0.21.10.50.20.50.8
Sr content in liver0.20.20.40.2-0.3-0.0-0.30.20.40.1-0.7-0.5-0.6-0.4
Zn content in liver1.31.54.4-1.8-1.11.60.61.6-0.42.10.2-0.40.51.2
Bone: minimum diameter1.01.94.71.61.0-1.1-2.1-0.42.2-1.7-1.3-1.0-1.2-0.1
Time in familiar zone, hab. session 11.41.43.31.71.7-1.8-1.1-1.40.70.10.40.80.41.3
Time in novel zone, hab. session 11.31.33.2-1.5-1.71.41.80.8-1.50.30.40.20.2-1.2
Total zone transitions, hab. session 10.20.20.5-0.1-0.0-0.00.7-0.4-0.70.20.70.70.5-0.3
Total locomotion distance, hab. session 10.20.30.8-0.7-0.40.40.90.2-0.70.40.50.40.5-0.2
Locomotion velocity, hab. session 10.20.30.8-0.9-0.50.70.90.4-0.60.40.40.20.4-0.3
Time in familiar zone, hab. session 20.60.71.71.30.9-1.3-1.0-0.80.7-1.0-0.20.2-0.20.1
Time in novel zone, hab. session 22.62.65.9-2.4-2.12.42.01.6-1.61.60.5-0.10.5-0.7
Total zone transitions, hab. session 20.30.41.0-0.3-0.0-0.10.8-0.3-0.7-0.00.90.91.00.1
Total locomotion distance, hab. session 20.50.61.6-1.0-0.40.51.30.1-1.10.40.90.81.10.1
Locomotion velocity, hab. session 20.30.41.0-0.7-0.00.20.9-0.2-0.90.30.80.81.00.3
Novel to familiar place preference ratio0.50.61.40.0-0.2-0.21.0-0.8-1.0-0.31.21.10.9-0.3
Novelty place preference1.21.33.20.20.3-0.61.2-1.4-1.40.01.81.81.40.2
Time in novel zone, NPP test0.80.82.10.20.0-0.41.0-1.0-1.2-0.11.41.41.1-0.2
Total zone transitions, NPP test0.00.10.20.30.4-0.2-0.3-0.20.30.1-0.0-0.0-0.10.1
Total locomotion distance, NPP test0.00.00.1-0.10.1-0.10.00.10.00.20.10.10.30.4
Locomotion velocity, NPP test0.20.30.80.10.6-0.40.1-0.4-0.20.30.50.60.70.9
Intraocular pressure2.23.28.0-0.90.4-0.21.6-0.7-1.82.82.22.02.32.3
Delta distance traveled before/after self-admin0.10.10.50.00.10.1-0.50.30.40.7-0.3-0.4-0.20.5
Delta ambulatory time before/after self-admin0.30.41.3-0.6-0.50.7-0.21.00.21.1-0.3-0.6-0.20.4
Parametrial fat weight0.71.63.81.01.5-1.80.4-1.9-0.9-0.21.11.71.11.0
Pavlov. Cond. lever latency2.53.19.3-2.0-3.02.31.32.5-0.6-0.1-0.9-1.2-0.7-2.1
Pavlov. Cond. magazine entry latency0.30.30.70.30.6-0.40.2-0.7-0.50.50.80.80.70.6
Pavlov. Cond. change in total contacts0.80.82.10.81.1-1.10.1-1.4-0.50.11.11.20.90.8
Pavlov. Cond. index score1.01.33.11.21.7-1.4-0.4-1.8-0.20.11.01.20.81.1
Pavlov. Cond. latency score1.31.74.41.42.1-1.6-0.6-1.9-0.00.21.01.20.81.5
Pavlov. Cond. lever contacts1.51.85.51.42.4-1.6-1.0-1.80.40.40.80.90.61.8
Pavlov. Cond. magazine entry number0.60.81.8-0.1-0.40.5-0.91.01.2-0.3-1.3-1.3-1.1-0.4
Pavlov. Cond. intertrial magazine entries0.91.12.91.11.0-0.4-1.7-0.11.60.1-1.0-1.0-1.20.3
Pavlov. Cond. lever-magazine prob. diff.1.21.43.41.21.8-1.5-0.4-1.8-0.20.21.11.20.81.3
Pavlov. Cond. response bias0.50.71.50.61.0-0.80.2-1.2-0.60.21.01.10.80.7
Pavlov. Cond. lever latency1.62.16.12.02.5-1.8-1.8-1.91.1-1.0-0.4-0.0-0.50.7
Pavlov. Cond. magazine entry latency2.73.210.2-2.2-3.22.41.62.6-0.80.5-0.5-0.9-0.4-1.7
Pavlov. Cond. change in total contacts1.93.06.4-2.2-2.51.82.51.6-1.91.41.20.71.2-0.6
Pavlov. Cond. index score2.33.19.8-2.2-3.12.41.62.6-0.80.8-0.3-0.7-0.1-1.5
Pavlov. Cond. latency score2.23.09.4-2.2-3.12.31.62.6-0.80.8-0.2-0.7-0.1-1.4
Pavlov. Cond. lever contacts1.52.16.9-1.9-2.61.91.52.1-0.80.7-0.0-0.40.1-1.1
Pavlov. Cond. magazine entry number3.44.213.12.63.6-2.8-2.0-2.81.1-0.60.30.80.22.0
Pavlov. Cond. intertrial magazine entries0.20.30.80.30.9-0.2-0.8-0.20.70.4-0.2-0.3-0.20.7
Pavlov. Cond. lever-magazine prob. diff.2.53.310.3-2.3-3.22.51.82.6-1.00.9-0.2-0.7-0.1-1.5
Pavlov. Cond. response bias2.22.99.1-2.3-3.02.22.02.3-1.20.90.1-0.30.2-1.3
Time in closed arm before self-admin0.60.82.0-0.8-0.20.41.00.0-1.11.41.00.81.00.7
Time in closed arm after self-admin1.01.02.6-1.0-1.01.4-0.11.60.31.2-0.9-1.3-0.9-0.2
Time in open arm before self-admin1.51.67.21.0-0.4-0.5-0.8-0.11.0-2.7-1.3-0.8-1.2-1.9
Time in open arm after self-admin0.30.31.80.4-0.0-0.60.3-0.7-0.2-1.40.30.60.3-0.6
Bone: periosteal estimation0.81.83.91.92.0-1.7-1.6-1.51.4-0.9-0.10.2-0.21.0
Bone: periosteal perimeter0.71.32.91.61.7-1.5-1.3-1.51.0-1.00.10.4-0.00.8
Bone: post-yield work1.62.45.90.60.9-1.41.2-1.9-1.60.22.12.41.91.1
Progressive ratio test 1 active lever presses1.82.25.9-1.3-2.01.8-0.02.40.80.5-1.4-1.8-1.2-1.4
Progressive ratio test 1 breakpoint2.02.46.1-1.3-2.11.9-0.12.50.90.3-1.5-1.9-1.3-1.6
Progressive ratio test 1 inactive lever presses0.70.91.70.3-0.70.4-0.81.01.0-0.8-1.2-1.2-1.2-1.3
Progressive ratio test 2 active lever presses1.01.12.8-1.1-1.71.30.31.70.30.1-0.9-1.1-0.7-1.2
Progressive ratio test 2 breakpoint1.01.12.9-1.1-1.61.30.21.70.30.2-0.9-1.1-0.7-1.1
Progressive ratio test 2 inactive lever presses0.20.30.7-0.1-0.0-0.20.5-0.3-0.40.40.80.80.80.5
Incentive Sensitization - Responses0.10.20.4-0.2-0.2-0.20.5-0.3-0.6-0.10.40.60.60.2
Incentive Sensitization - Breakpoint0.20.20.4-0.1-0.0-0.30.5-0.4-0.60.00.50.70.70.3
Sum of active levers in priming session hrs 5-60.80.71.60.71.0-0.9-0.3-1.00.10.41.00.90.91.3
Progressive ratio2.33.57.60.5-0.00.5-2.31.32.7-1.0-2.8-2.7-2.6-1.2
Food seeking constrained by brief footshock1.21.53.00.8-0.30.0-1.40.71.5-1.1-1.7-1.5-1.7-1.2
Seeking ratio, punishment vs. effort0.81.12.9-0.1-0.3-0.41.5-0.9-1.7-0.21.51.61.3-0.1
Retroperitoneal fat weight0.52.24.70.00.7-0.91.4-1.6-1.90.52.02.22.01.3
Reaction time number correct0.40.82.3-0.7-0.60.51.5-0.2-1.50.41.10.90.8-0.3
Reaction time mean minus median0.30.82.71.00.7-0.4-1.70.01.4-0.4-0.8-0.9-0.90.3
Reaction time mean minus median AUC0.20.40.90.90.9-0.7-0.7-0.80.30.30.50.40.20.9
Reaction time num false alarms0.71.02.6-1.6-1.01.11.40.8-1.01.20.50.30.80.1
Reaction time num false alarms AUC1.01.63.9-2.0-1.61.61.71.2-1.21.30.50.10.6-0.4
Reaction time trials correct on left0.40.82.3-0.7-0.60.51.5-0.2-1.50.41.10.90.8-0.3
Reaction time trials on left0.40.82.4-0.7-0.70.51.5-0.1-1.50.41.10.90.8-0.4
Reaction time mean0.10.20.60.60.3-0.2-0.8-0.20.6-0.4-0.3-0.4-0.5-0.2
Reaction time mean AUC0.10.20.40.60.4-0.2-0.7-0.30.5-0.4-0.2-0.2-0.4-0.2
Median of all reaction times0.00.00.20.20.10.1-0.3-0.10.2-0.2-0.2-0.2-0.3-0.4
Reaction time omissions1.42.15.7-1.8-2.22.41.02.2-0.40.8-0.1-0.9-0.3-1.2
Reaction time false alarm rate0.40.51.5-1.2-0.91.00.61.0-0.20.8-0.2-0.40.1-0.0
Reaction time premature initiation rate0.10.10.50.20.10.1-0.30.00.2-0.7-0.4-0.4-0.5-0.5
Reaction time premature initiations0.10.20.6-0.2-0.20.30.6-0.2-0.8-0.40.30.30.1-0.6
Std. dev. reaction times0.20.41.11.00.6-0.5-1.1-0.50.7-0.5-0.2-0.3-0.50.1
Reaction time trials completed0.40.82.4-0.7-0.70.51.5-0.1-1.50.41.10.90.8-0.4
Reaction time trials AUC0.40.72.0-0.7-0.80.61.4-0.0-1.40.20.90.70.6-0.6
Run reversals in cocaine runway, females0.70.72.0-1.4-0.60.81.00.9-0.71.30.30.20.80.6
Run reversals in cocaine runway, males1.21.23.3-0.7-1.00.31.8-0.1-1.70.11.21.31.2-0.6
Latency to leave start box in cocaine runway1.71.94.6-0.60.7-0.41.2-0.8-1.41.41.71.71.92.1
Latency to leave start box in cocaine runway, F0.91.12.5-0.50.5-0.21.0-0.5-1.10.91.31.31.51.6
Latency to leave start box in cocaine runway, M1.21.12.5-0.60.3-0.21.0-0.5-1.11.31.21.21.41.6
Std. dev. time between licks in bursts2.02.76.5-2.5-2.02.11.92.0-1.42.10.60.00.90.1
Total sessions with >9 infusions3.54.311.3-2.6-2.93.11.03.4-0.11.6-1.1-1.8-0.9-1.5
Short access day 1 total inactive lever presses0.30.41.6-0.8-0.60.60.70.6-0.61.30.50.30.60.4
Short access day 10 total inactive lever presses0.51.33.61.60.9-1.3-1.3-1.01.1-1.9-0.8-0.4-0.9-0.6
Short access day 1 total infusions1.62.25.6-1.9-2.02.10.82.4-0.21.7-0.6-1.1-0.4-0.6
Short access day 10 total infusions0.81.03.0-1.1-1.41.40.31.70.10.7-0.6-0.9-0.5-0.8
Short access total infusions1.51.95.2-1.7-1.92.00.62.30.01.5-0.6-1.1-0.5-0.7
Short access day 1 locomotion2.63.27.9-1.7-2.72.21.02.3-0.2-0.6-1.3-1.5-1.2-2.8
Short access day 10 total locomotion0.40.72.2-1.0-1.50.90.91.0-0.6-0.2-0.2-0.3-0.0-1.0
Short access total locomotion1.21.54.1-1.4-2.01.61.01.7-0.40.1-0.5-0.8-0.5-1.5
One hour access (0.3 mA shock)2.22.57.0-0.8-2.11.6-0.01.80.8-1.2-1.5-1.7-1.5-2.6
Compulsive drug intake0.60.81.8-1.0-0.71.3-0.01.30.01.4-0.5-1.0-0.50.0
One hour access (shock baseline)0.81.23.80.4-0.70.0-0.50.51.1-2.0-1.2-0.9-1.0-1.9
Social response proportion0.40.51.2-0.8-0.80.81.00.4-1.10.70.60.30.4-0.4
Social responses0.10.20.7-0.3-0.20.50.30.1-0.50.80.60.20.30.2
Social time0.40.51.2-0.2-0.70.8-0.30.90.40.0-0.8-1.0-0.9-1.1
Soleus weight0.20.61.51.10.7-0.7-1.2-0.41.1-0.5-0.8-0.6-0.90.0
Bone: stiffness0.20.41.10.30.9-0.4-0.0-0.7-0.10.70.80.60.61.1
Tibialis anterior weight0.41.22.91.20.5-0.6-1.70.01.6-0.7-1.4-1.2-1.5-0.3
Time to tail flick, vehicle, before self-admin0.40.41.70.70.2-0.9-0.5-0.30.5-1.3-0.7-0.2-0.50.1
Time to tail flick, vehicle, after self-admin1.21.63.7-0.10.4-0.91.3-1.2-1.50.51.71.91.81.2
Time to tail flick, test, before self-admin0.40.51.1-0.20.0-0.30.8-0.6-1.00.40.81.00.90.5
Time to tail flick, test, after self-admin0.10.10.60.4-0.0-0.5-0.0-0.40.1-0.8-0.10.20.0-0.2
Delta time to tail flick, vehicle, before/after SA0.40.40.9-0.30.1-0.00.8-0.3-0.90.70.90.90.90.2
Delta time to tail flick, test, before/after SA0.80.81.80.80.0-0.2-1.10.11.3-1.3-1.0-0.9-1.1-0.8
Tibia length3.08.317.51.84.0-3.1-0.2-3.6-0.81.53.03.33.04.2
Ambulatory time before self-admin0.10.10.3-0.4-0.30.20.60.2-0.60.50.30.30.3-0.0
Ambulatory time after self-admin0.40.52.7-0.20.2-0.10.20.1-0.41.60.50.40.51.2
Bone: tissue strength1.21.25.1-1.3-0.30.90.90.7-0.92.30.80.40.91.2
Total heroin consumption1.01.12.51.51.5-1.6-1.0-1.50.6-0.60.50.70.40.8
Bone: trabecular number1.01.73.7-0.8-1.21.6-0.61.91.10.0-1.5-1.9-1.5-1.0
Bone: trabecular spacing0.30.50.9-0.20.1-0.20.9-0.6-0.90.60.90.90.90.5
Bone: trabecular thickness0.10.20.40.60.5-0.4-0.6-0.20.6-0.5-0.2-0.2-0.3-0.1
Bone: trabecular tissue density0.50.71.90.70.6-1.00.5-1.4-0.6-0.90.81.10.7-0.1
Water consumed over 24 hours3.14.28.6-0.30.8-0.92.1-1.7-2.61.62.82.92.71.9
Number of responses in last shaping day1.11.22.6-1.1-1.11.60.01.60.40.4-1.0-1.4-1.1-1.1