Hub : Genes

Medag

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC mRNA stability Medag 0.08 0.06 8.4e-03 0.05 0.02 0.03 -0 4.8e-03 6.9e-02 3.2e-02 3.7e-01
2 Adipose isoform ratio NM_001398808.1 0.04 0.03 7.3e-04 0.02 0.02 0.02 0.01 6.5e-03 2.7e-03 6.1e-03 9.3e-03
3 Adipose isoform ratio NM_001398809.1 0.04 0.03 9.3e-04 0.02 0.02 0.02 0.01 5.9e-03 3.3e-03 4.5e-03 8.9e-03
4 NAcc intron excision ratio chr12_10653776_10656355 0.03 0.02 3.4e-05 0.03 0.03 0.03 0.03 6.3e-05 3.3e-05 1.5e-05 3.1e-05
5 NAcc intron excision ratio chr12_10653776_10658987 0.03 0.02 5.5e-05 0.03 0.03 0.03 0.03 9.2e-05 5.6e-05 3.8e-05 5.8e-05
6 OFC gene expression Medag 0.37 0.13 7.7e-12 0.37 0.49 0.47 0.49 1.1e-09 2.3e-13 8.7e-13 2.8e-13
7 Brain gene expression Medag 0.21 0.08 0.0e+00 0.28 0.3 0.3 0.29 1.0e-25 1.2e-28 7.4e-28 5.4e-27
8 NAcc gene expression Medag 0.13 0.05 0.0e+00 0.28 0.28 0.27 0.28 5.0e-42 1.1e-41 8.0e-41 5.6e-43
9 IC gene expression Medag 0.2 0.08 2.5e-13 0.3 0.3 0.27 0.29 7.0e-13 4.5e-13 9.1e-12 8.1e-13
10 BLA gene expression Medag 0.2 0.11 1.3e-08 0.17 0.16 0.16 0.16 3.2e-09 8.1e-09 9.2e-09 6.6e-09
11 IL gene expression Medag 0.16 0.11 7.5e-04 0.12 0.09 0.1 0.12 7.1e-04 3.3e-03 2.8e-03 1.1e-03
12 PL gene expression Medag 0.09 0.04 5.6e-17 0.17 0.16 0.17 0.17 9.1e-19 1.2e-17 2.8e-18 4.8e-18

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density4.17.012.2-3.2-3.43.43.5-3.42.22.31.92.11.51.91.8
Area under the delay curve0.40.51.30.91.1-1.1-0.00.0-0.5-0.7-0.6-0.5-0.5-0.8-0.7
BMI with tail2.38.114.8-3.1-3.03.03.9-3.82.82.52.52.62.62.21.6
BMI without tail0.20.51.9-0.6-0.40.40.6-0.6-0.4-0.5-0.9-0.6-0.4-1.1-1.4
Body weight4.419.345.8-6.8-6.76.75.1-5.03.23.62.52.62.31.71.5
Weight adjusted by age0.40.61.6-0.2-0.50.50.4-0.3-0.7-0.7-1.3-0.9-1.1-1.0-1.1
Bone surface2.75.09.8-2.8-3.13.03.1-3.01.71.91.31.50.91.31.2
Bone volume4.37.812.1-3.3-3.23.23.5-3.32.62.72.22.51.92.42.1
Breakpoint value in progressive ratio session0.10.20.50.10.3-0.30.1-0.2-0.4-0.2-0.6-0.4-0.3-0.5-0.7
Number of licking bursts0.30.41.00.2-0.70.60.4-0.4-0.6-0.6-0.6-0.7-0.7-1.0-0.9
Context. condit. distance diff. score1.61.93.9-2.0-1.81.70.8-0.81.41.71.11.31.11.20.8
Locomotion velocity, session 10.90.91.80.20.5-0.6-1.11.1-1.0-1.0-1.1-1.1-1.1-1.3-0.8
Locomotion distance, session 11.92.43.61.21.4-1.4-1.21.3-1.7-1.9-1.9-1.7-1.9-1.7-1.2
Locomotion velocity, session 21.31.52.90.60.6-0.6-0.30.3-1.5-1.6-1.5-1.6-1.6-1.7-1.4
Locomotion distance, session 23.04.26.71.51.2-1.3-1.41.5-2.5-2.4-2.6-2.5-2.6-2.6-1.8
Locomotion velocity, session 30.70.81.0-1.0-0.90.90.8-0.81.01.01.01.00.80.90.7
Locomotion distance, session 30.30.31.10.00.1-0.1-1.01.1-0.3-0.3-0.3-0.3-0.4-0.4-0.7
Stereotopy head waving bouts, day 30.80.92.0-0.3-0.10.1-0.50.6-1.1-0.8-1.3-1.2-1.3-1.4-1.3
Stereotopy head waving duration, day 30.10.10.20.30.2-0.2-0.10.1-0.3-0.1-0.3-0.3-0.4-0.40.0
Locomotion velocity, session 70.10.10.4-0.00.4-0.4-0.60.60.20.40.10.20.20.10.5
Locomotion distance, session 70.10.10.50.40.4-0.5-0.70.7-0.00.2-0.1-0.10.1-0.20.4
Stereotopy head waving bouts, day 72.83.14.41.51.6-1.7-2.12.1-1.8-1.6-1.7-1.8-1.8-1.6-1.8
Stereotopy head waving duration, day 71.31.52.01.11.2-1.2-1.41.4-1.2-1.2-1.1-1.2-1.3-1.0-1.3
Locomotion velocity, session 81.11.31.90.50.7-0.7-1.31.4-1.3-1.2-1.3-1.3-1.3-1.2-1.2
Locomotion distance, session 80.20.40.7-0.8-0.80.8-0.10.2-0.4-0.1-0.7-0.6-0.7-0.6-0.5
Degree of sensitization distance0.20.20.60.60.8-0.8-0.30.2-0.4-0.3-0.5-0.4-0.2-0.50.2
Degree of sensitization stereotypy0.91.01.61.11.3-1.3-1.21.2-0.9-0.9-0.7-0.8-0.8-0.6-0.9
Conditioned locomotion0.30.42.01.40.5-0.5-0.50.5-0.7-0.6-0.4-0.6-0.6-0.4-0.3
Cocaine response after cond. corrected0.30.40.70.30.6-0.60.5-0.50.60.30.80.70.80.80.8
Cocaine response after cond. not corrected0.50.61.30.30.5-0.50.5-0.60.80.51.00.91.10.91.1
Cocaine response before conditioning0.30.30.6-0.3-0.60.60.3-0.30.60.70.60.50.70.50.8
Saline control response2.33.05.80.90.3-0.4-1.31.3-2.0-1.7-2.3-2.2-2.4-2.2-2.1
Bone: connectivity density2.33.59.0-2.5-3.03.02.6-2.41.11.40.70.90.40.80.7
Bone: cortical apparent density0.40.61.0-0.8-0.50.50.7-0.70.80.70.90.80.80.91.0
Bone: cortical area1.42.13.5-1.9-1.81.81.8-1.81.31.41.11.21.01.00.8
Bone: cortical porosity2.02.22.81.51.5-1.5-1.61.6-1.6-1.4-1.3-1.4-1.7-1.2-1.4
Bone: cortical porosity2.02.13.11.51.5-1.6-1.81.7-1.5-1.3-1.3-1.4-1.6-1.1-1.3
Bone: cortical thickness1.11.72.9-1.6-1.71.61.7-1.61.11.21.11.10.90.90.9
Bone: cortical thickness0.40.52.21.50.5-0.5-0.40.4-0.7-0.5-0.6-0.7-0.7-0.3-0.7
Bone: cortical tissue density0.30.40.8-0.7-0.40.40.6-0.60.70.50.80.70.70.80.9
Condit. Reinf. active minus inactive responses1.01.22.3-1.5-1.31.40.8-0.71.11.10.91.01.00.91.0
Condit. Reinf. active-inactive response ratio1.51.72.2-1.3-1.21.21.0-0.91.51.41.41.51.51.31.1
Condit. Reinf. active responses0.10.10.6-0.8-0.50.50.3-0.30.30.20.20.30.20.20.3
Condit. Reinf. inactive responses0.60.71.00.81.0-1.0-0.70.6-0.9-0.9-0.9-0.8-0.8-0.9-0.5
Incentive salience index mean0.20.30.5-0.7-0.50.60.3-0.30.60.50.50.60.50.50.6
Condit. Reinf. lever presses0.10.20.80.70.9-0.9-0.20.1-0.1-0.20.00.0-0.10.00.1
Condit. Reinf. active minus inactive responses0.81.01.90.70.4-0.4-0.90.9-1.1-1.0-1.1-1.2-1.0-1.4-1.3
Condit. Reinf. active-inactive response ratio1.61.83.71.00.9-0.9-1.21.2-1.3-1.4-1.5-1.4-1.3-1.7-1.9
Condit. Reinf. active responses0.40.51.20.3-0.00.0-0.60.6-0.8-0.7-0.9-0.9-0.9-1.1-1.0
Condit. Reinf. inactive responses0.10.10.4-0.6-0.60.60.2-0.10.10.30.10.1-0.20.10.4
Condit. Reinf. lever presses0.20.30.4-0.5-0.60.60.6-0.50.60.60.50.60.50.30.3
Condit. Reinf. lever reinforcers received0.30.41.00.0-0.20.2-0.50.4-0.7-0.6-0.8-0.8-0.8-1.0-0.9
Conditioned reinforcement - actives0.20.30.9-0.9-0.80.70.0-0.0-0.4-0.1-0.6-0.5-0.6-0.3-0.3
Conditioned reinforcement - inactives0.10.10.4-0.7-0.20.2-0.20.20.10.20.20.20.20.30.4
Conditioned locomotion0.10.10.3-0.5-0.40.40.5-0.6-0.1-0.2-0.1-0.20.1-0.4-0.0
Patch foraging indifference point 0 sec1.42.63.6-1.6-1.91.91.9-1.91.41.51.71.41.51.31.3
Patch foraging indifference point AUC0.00.10.2-0.2-0.30.30.5-0.4-0.0-0.1-0.1-0.1-0.2-0.20.1
Delay disc. indifference point, 0s delay0.30.41.6-0.3-0.60.61.3-1.20.40.40.30.30.10.00.1
Delay disc. indifference point, 16s delay0.10.10.2-0.10.5-0.50.3-0.40.30.20.30.40.50.10.1
Delay disc. indifference point, 2s delay0.60.61.81.31.3-1.3-0.30.3-0.6-0.6-0.6-0.5-0.8-0.5-0.2
Delay disc. indifference point, 24s delay0.20.20.60.70.8-0.80.1-0.2-0.2-0.3-0.1-0.1-0.0-0.5-0.3
Delay disc. indifference point, 4s delay0.30.31.10.81.0-1.00.3-0.3-0.2-0.5-0.2-0.1-0.0-0.5-0.6
Delay disc. indifference point, 8s delay0.30.30.90.90.7-0.70.1-0.1-0.4-0.6-0.4-0.4-0.3-0.6-0.5
Indifference point function ln k0.10.20.7-0.8-0.80.80.2-0.20.00.2-0.1-0.1-0.10.1-0.2
Indifference point function log k0.10.20.7-0.8-0.80.80.2-0.20.00.2-0.1-0.1-0.10.1-0.2
Patch foraging total patch changes 0 sec1.22.33.3-1.5-1.81.81.7-1.71.31.51.61.31.41.31.3
Patch foraging total patch changes 12 sec2.63.44.4-1.8-1.91.92.1-2.11.81.71.91.71.81.61.8
Patch foraging total patch changes 18 sec0.50.71.1-0.4-0.60.61.1-1.10.80.70.90.80.90.80.9
Patch foraging total patch changes 24 sec0.30.40.7-0.4-0.60.60.8-0.80.60.60.80.60.80.40.8
Patch foraging total patch changes 6 sec0.30.50.7-0.6-0.80.80.7-0.70.60.70.80.60.70.60.6
Patch foraging time to switch 0 sec0.20.40.90.90.9-0.9-0.1-0.00.40.30.70.60.80.60.4
Patch foraging water rate 0 sec0.51.03.5-1.9-1.81.80.9-0.80.40.60.20.20.20.00.2
Patch foraging water rate 12 sec0.20.42.1-1.4-1.01.00.1-0.1-0.20.1-0.5-0.3-0.4-0.5-0.7
Patch foraging water rate 18 sec0.91.42.10.50.9-0.9-1.41.4-1.1-1.1-1.3-1.2-1.1-1.3-1.3
Patch foraging water rate 24 sec1.01.43.9-0.6-0.30.3-0.70.8-1.2-1.1-1.6-1.4-1.4-1.5-2.0
Patch foraging water rate 6 sec0.91.43.8-2.0-1.61.61.0-1.01.01.20.70.90.90.70.5
Seeking ratio, delayed vs. immediate footshock0.40.51.81.10.8-0.8-1.31.2-0.2-0.20.5-0.10.20.1-0.0
Distance traveled before self-admin0.50.71.3-0.10.2-0.10.9-1.00.80.61.11.01.01.11.0
Distance traveled after self-admin0.20.21.11.10.5-0.5-0.10.1-0.4-0.3-0.4-0.3-0.5-0.1-0.2
Extensor digitorum longus weight1.03.87.7-2.8-2.72.72.1-2.01.51.91.31.31.11.31.5
Bone: elastic displacement1.61.92.60.41.1-1.1-1.31.3-1.5-1.6-1.5-1.5-1.5-1.5-1.6
Bone: elastic work0.40.51.1-0.8-1.01.00.3-0.2-0.5-0.4-0.6-0.6-0.8-0.7-1.1
Bone: endosteal estimation0.20.40.7-0.6-0.80.8-0.00.1-0.5-0.2-0.8-0.7-0.7-0.6-0.8
Bone: endosteal perimeter0.30.72.5-1.6-1.41.40.6-0.60.50.80.20.40.30.2-0.1
Epididymis fat weight2.37.98.8-2.5-2.72.72.9-3.02.92.92.92.82.82.62.9
Delta time in closed arm before/after self-admin0.20.20.8-0.9-0.50.50.4-0.40.30.40.10.20.00.4-0.1
Delta time in open arm before/after self-admin1.61.66.32.52.1-2.1-0.70.6-0.9-1.0-0.8-0.7-0.6-0.3-0.1
Diff in mean of infusions in LGA sessions0.20.20.7-0.10.2-0.20.2-0.30.60.50.40.60.80.50.1
Delay discount exponential model param0.60.71.9-1.1-1.41.40.2-0.20.60.70.60.50.40.80.7
Extinction: sum of active levers before priming1.11.32.8-1.0-1.01.01.7-1.71.10.80.91.11.20.70.8
Active lever presses in extinction session 62.22.25.9-1.1-1.61.62.4-2.41.21.21.01.11.20.80.7
Bone: final force0.20.30.6-0.2-0.60.60.8-0.7-0.2-0.3-0.4-0.4-0.5-0.6-0.8
Bone: final moment0.20.20.5-0.2-0.50.50.7-0.6-0.2-0.3-0.4-0.4-0.4-0.5-0.7
Food consumed during 24 hour testing period1.52.14.42.11.6-1.5-1.21.1-1.4-1.6-1.3-1.4-1.2-1.4-1.3
Glucose0.40.71.3-0.3-0.30.30.6-0.70.80.81.00.91.11.21.1
Heart weight0.30.41.4-1.2-1.01.00.6-0.5-0.1-0.2-0.2-0.2-0.2-0.6-0.4
Delay discount hyperbolic model param0.50.61.6-1.1-1.31.30.1-0.10.50.70.60.50.40.80.6
Intermittent access intake day 1-15 change0.10.20.6-0.3-0.30.30.4-0.4-0.4-0.1-0.5-0.4-0.8-0.4-0.1
Intermittent access intake escalation0.10.10.4-0.3-0.40.40.6-0.6-0.20.1-0.3-0.2-0.5-0.10.2
Intermittent access intake escalation 20.00.00.20.0-0.10.00.4-0.4-0.10.1-0.1-0.0-0.20.00.2
Intermitt. access day 1 inactive lever presses0.10.52.0-1.4-0.90.90.6-0.60.50.20.40.40.7-0.2-0.2
Intermitt. access day 15 inactive lever presses0.30.72.40.60.7-0.7-0.30.40.70.80.70.90.71.51.1
Intermitt. access escalation Index0.00.00.10.1-0.10.20.2-0.20.2-0.00.10.10.10.0-0.3
Intermittent access day 1 total infusions1.62.64.41.71.6-1.6-2.12.1-1.7-1.4-1.6-1.6-1.4-1.2-1.2
Intermittent access day 15 total infusions0.71.11.90.90.7-0.7-1.01.0-1.3-0.9-1.3-1.2-1.4-0.9-0.7
Intermittent access terminal intake (last 3 days)0.50.71.31.10.9-0.9-0.50.5-1.0-0.7-1.0-0.9-1.0-0.6-0.4
Intermittent access total infusions0.70.91.71.31.1-1.1-0.60.5-1.1-0.9-0.9-1.0-1.0-0.7-0.6
Intermittent access day 1 locomotion0.50.61.41.20.9-0.9-0.80.8-0.8-0.8-0.7-0.7-0.7-0.4-0.4
Intermittent access day 15 total locomotion1.42.53.51.91.6-1.6-1.61.7-1.7-1.5-1.6-1.6-1.6-1.3-1.1
Intermittent access total locomotion1.11.32.61.61.3-1.3-0.70.8-1.2-1.3-1.2-1.1-1.1-0.9-0.7
Intermittent access standard deviation0.20.52.0-0.4-0.50.51.3-1.40.40.50.70.50.50.30.6
Left kidney weight3.415.937.7-5.9-6.16.14.1-4.03.23.42.62.62.51.82.0
Right kidney weight3.817.238.5-6.2-6.26.24.4-4.23.33.52.82.82.82.02.0
Cocaine induced anxiety0.10.20.60.80.6-0.6-0.70.7-0.1-0.1-0.1-0.1-0.10.20.2
Post-drug Anxiety0.50.61.51.21.2-1.2-0.50.50.20.20.50.40.40.70.8
Baseline Anxiety0.60.71.4-0.30.1-0.10.8-0.90.90.81.21.01.01.01.0
Tail length0.83.26.5-2.0-1.91.9-0.60.7-1.5-0.9-2.1-2.0-2.0-2.6-2.2
Length with tail1.98.229.7-5.2-5.55.42.2-2.00.81.60.10.1-0.2-0.7-0.2
Length without tail5.818.541.8-6.2-6.56.54.5-4.33.53.83.02.92.52.32.6
Times rat made contact with spout1.01.22.00.60.2-0.2-0.80.9-1.1-1.2-1.4-1.3-1.4-1.4-1.4
Lifetime Intake0.60.71.31.21.1-1.1-0.60.5-1.0-0.8-0.9-0.8-0.8-0.6-0.5
Liver weight, left1.52.57.5-2.0-2.72.71.7-1.51.01.50.50.80.60.90.2
Liver weight, right1.01.85.1-1.9-2.32.21.7-1.60.80.90.50.50.30.30.2
Locomotor activity0.20.31.7-1.3-0.90.90.1-0.00.00.2-0.1-0.1-0.1-0.6-0.2
Locomotor testing distance0.30.51.2-1.1-1.11.10.7-0.70.60.60.40.50.60.20.4
Locomotor testing rearing0.00.00.10.30.0-0.00.1-0.10.10.2-0.00.20.00.30.1
Locomotion in novel chamber6.88.712.22.01.8-1.8-2.82.8-3.2-3.3-3.3-3.3-3.5-3.4-3.2
Locomotion in novel chamber post-restriction2.64.27.80.31.0-1.0-1.41.4-2.3-2.4-2.5-2.4-2.5-2.7-2.8
Fecal boli incidents, locomotor time 10.60.82.7-1.6-1.61.60.8-0.80.50.60.30.30.4-0.1-0.1
Change in fecal boli incidents, locomotor task0.10.10.70.40.9-0.80.0-0.1-0.1-0.30.10.1-0.00.20.0
Time >=10cm from walls, locomotor time 10.10.10.50.20.1-0.1-0.10.10.10.10.40.2-0.00.70.2
Bouts of movement, locomotor time 10.10.10.40.0-0.10.1-0.20.3-0.1-0.2-0.3-0.2-0.1-0.7-0.2
Total resting periods, locomotor time 10.00.00.20.1-0.10.1-0.20.30.0-0.1-0.00.00.1-0.5-0.1
Rest time, locomotor task time 10.70.91.21.00.8-0.8-1.11.0-0.9-1.1-0.8-0.9-0.9-1.1-0.7
Distance moved, locomotor task time 10.10.10.3-0.6-0.40.40.6-0.50.30.30.10.20.20.40.1
Vertical activity count, locomotor time 10.41.02.4-1.4-1.21.21.6-1.50.90.70.60.70.80.50.3
Time >=10cm from walls, locomotor time 20.20.30.8-0.6-0.90.90.5-0.50.50.70.40.40.20.50.5
Bouts of movement, locomotor time 20.81.33.1-1.5-1.81.71.5-1.50.71.00.50.60.30.60.7
Total resting periods, locomotor time 21.01.83.4-1.7-1.81.81.8-1.81.01.20.80.90.60.91.0
Rest time, locomotor task time 20.20.30.70.60.8-0.7-0.80.8-0.2-0.30.1-0.1-0.1-0.1-0.2
Distance moved, locomotor task time 20.20.20.5-0.2-0.60.50.5-0.4-0.3-0.3-0.7-0.4-0.5-0.7-0.3
Vertical activity count, locomotor time 20.71.02.5-1.5-1.41.41.5-1.60.40.1-0.20.20.2-0.4-0.1
Light reinforcement 10.10.31.30.91.2-1.1-0.40.3-0.1-0.30.00.1-0.10.40.2
Light reinforcement 20.10.20.4-0.50.2-0.20.2-0.20.40.20.60.60.60.60.5
Bone: marrow area0.20.40.7-0.5-0.70.7-0.10.1-0.5-0.3-0.8-0.7-0.8-0.7-0.9
Bone: maximum diameter0.71.23.5-1.9-1.61.61.2-1.10.81.10.60.70.40.60.4
Bone: maximum force0.20.41.2-0.5-1.01.01.1-1.00.20.20.00.0-0.2-0.1-0.3
Bone: maximum moment0.20.31.0-0.5-0.90.91.0-0.90.10.1-0.00.0-0.1-0.2-0.2
Mean time between licks in bursts0.10.30.70.50.7-0.7-0.80.7-0.7-0.4-0.4-0.6-0.4-0.5-0.2
Mean num. licks in bursts0.30.51.20.40.9-0.9-1.11.1-0.5-0.5-0.6-0.5-0.6-0.3-0.4
Cd content in liver1.31.52.40.30.8-0.8-1.51.5-1.2-1.3-1.3-1.2-1.2-1.4-1.5
Co content in liver2.32.63.81.92.0-2.0-1.21.1-1.7-1.8-1.6-1.6-1.6-1.5-1.0
Cu content in liver0.91.11.4-1.1-1.11.11.1-1.11.21.10.91.10.90.91.0
Fe content in liver7.08.510.5-3.0-3.23.23.0-2.93.03.12.72.92.72.72.2
K content in liver0.10.10.30.50.5-0.5-0.30.3-0.3-0.3-0.3-0.2-0.3-0.3-0.3
Mg content in liver0.50.50.90.90.9-1.0-0.90.9-0.5-0.5-0.4-0.5-0.4-0.5-0.3
Mn content in liver0.40.40.70.10.1-0.1-0.60.7-0.7-0.7-0.7-0.8-0.8-0.8-0.8
Na content in liver0.20.20.5-0.5-0.50.50.7-0.70.20.20.20.20.10.20.3
Rb content in liver0.50.61.10.91.0-1.0-0.40.30.60.50.60.70.80.70.9
Se content in liver3.44.06.3-1.0-1.31.32.2-2.22.21.92.22.22.12.12.5
Sr content in liver0.40.40.8-0.5-0.30.2-0.30.3-0.6-0.5-0.8-0.7-0.8-0.8-0.9
Zn content in liver0.80.92.6-1.6-1.51.51.1-1.10.50.60.30.40.20.20.5
Bone: minimum diameter0.00.00.00.20.2-0.2-0.00.0-0.10.0-0.2-0.1-0.1-0.1-0.1
Time in familiar zone, hab. session 10.30.30.7-0.9-0.60.60.5-0.50.50.30.40.40.30.40.6
Time in novel zone, hab. session 10.10.10.4-0.5-0.60.60.3-0.30.30.40.20.20.30.1-0.1
Total zone transitions, hab. session 13.95.58.31.61.5-1.6-2.82.9-2.5-2.2-2.6-2.6-2.5-2.6-2.1
Total locomotion distance, hab. session 11.31.84.01.61.2-1.3-2.02.0-1.2-0.9-1.1-1.2-1.1-1.1-0.8
Locomotion velocity, hab. session 12.02.85.22.31.9-1.9-2.32.2-1.5-1.2-1.3-1.3-1.2-1.1-1.0
Time in familiar zone, hab. session 22.42.53.6-1.6-1.41.41.3-1.31.71.91.61.71.41.81.9
Time in novel zone, hab. session 21.41.41.91.31.2-1.2-1.00.9-1.2-1.4-1.1-1.1-0.9-1.2-1.3
Total zone transitions, hab. session 23.95.07.51.51.5-1.5-1.81.8-2.6-2.6-2.7-2.6-2.7-2.7-2.2
Total locomotion distance, hab. session 23.34.45.02.12.0-2.0-2.22.2-2.2-2.2-2.1-2.1-2.1-1.9-1.9
Locomotion velocity, hab. session 23.54.65.42.22.0-2.1-2.22.2-2.3-2.3-2.2-2.2-2.2-2.0-1.9
Novel to familiar place preference ratio0.10.20.6-0.00.4-0.4-0.00.0-0.4-0.5-0.4-0.4-0.3-0.4-0.8
Novelty place preference0.00.00.3-0.30.1-0.10.1-0.1-0.1-0.2-0.2-0.1-0.1-0.1-0.5
Time in novel zone, NPP test0.00.10.3-0.6-0.10.10.2-0.2-0.0-0.1-0.1-0.1-0.10.0-0.4
Total zone transitions, NPP test1.62.33.80.50.6-0.6-1.41.4-1.8-1.6-1.9-1.9-2.0-1.8-1.5
Total locomotion distance, NPP test1.92.64.21.51.6-1.6-2.02.0-1.6-1.4-1.5-1.5-1.4-1.3-1.4
Locomotion velocity, NPP test2.73.85.21.91.9-1.9-2.32.3-2.0-1.8-1.9-1.9-1.9-1.8-1.7
Intraocular pressure0.60.92.1-1.4-1.01.00.5-0.50.91.20.90.90.90.91.0
Delta distance traveled before/after self-admin2.12.23.51.50.7-0.8-1.11.2-1.6-1.5-1.8-1.7-1.9-1.7-1.7
Delta ambulatory time before/after self-admin1.21.52.31.50.8-0.8-1.01.0-1.3-1.1-1.5-1.3-1.5-1.2-1.3
Parametrial fat weight1.22.87.0-2.7-1.81.81.4-1.51.61.71.71.51.41.31.4
Pavlov. Cond. lever latency3.34.17.8-2.7-2.82.82.2-2.11.81.71.51.61.51.41.5
Pavlov. Cond. magazine entry latency2.63.35.41.51.4-1.4-2.32.3-1.9-1.5-1.8-1.9-1.6-1.7-2.2
Pavlov. Cond. change in total contacts0.50.51.10.91.0-1.0-1.01.0-0.5-0.4-0.4-0.4-0.3-0.5-0.5
Pavlov. Cond. index score2.43.04.62.11.9-1.9-2.12.1-1.6-1.4-1.4-1.5-1.3-1.3-1.6
Pavlov. Cond. latency score3.24.05.82.42.3-2.3-2.32.3-1.9-1.8-1.7-1.8-1.7-1.6-1.8
Pavlov. Cond. lever contacts3.44.18.02.72.8-2.8-2.42.3-1.7-1.6-1.4-1.5-1.3-1.3-1.4
Pavlov. Cond. magazine entry number1.82.34.8-1.3-1.21.22.2-2.21.51.11.41.51.21.31.6
Pavlov. Cond. intertrial magazine entries0.10.20.2-0.4-0.30.40.5-0.50.50.20.30.50.40.30.4
Pavlov. Cond. lever-magazine prob. diff.2.02.53.91.91.8-1.8-2.01.9-1.4-1.2-1.2-1.3-1.1-1.2-1.5
Pavlov. Cond. response bias2.32.85.11.71.7-1.7-2.32.2-1.6-1.3-1.5-1.5-1.3-1.3-1.7
Pavlov. Cond. lever latency0.00.10.2-0.3-0.40.40.3-0.30.00.10.10.00.00.10.2
Pavlov. Cond. magazine entry latency0.00.00.1-0.30.1-0.1-0.30.20.00.20.20.00.10.0-0.2
Pavlov. Cond. change in total contacts0.10.10.5-0.7-0.40.4-0.20.2-0.00.1-0.1-0.1-0.2-0.30.0
Pavlov. Cond. index score0.10.10.40.00.3-0.3-0.60.6-0.3-0.2-0.2-0.3-0.2-0.4-0.4
Pavlov. Cond. latency score0.10.10.4-0.00.2-0.2-0.70.6-0.2-0.1-0.2-0.3-0.2-0.3-0.3
Pavlov. Cond. lever contacts0.00.10.20.30.5-0.5-0.20.10.20.10.20.20.20.10.1
Pavlov. Cond. magazine entry number0.00.10.10.4-0.10.10.3-0.2-0.1-0.3-0.3-0.2-0.2-0.1-0.2
Pavlov. Cond. intertrial magazine entries0.30.40.80.90.2-0.2-0.40.4-0.7-0.8-0.8-0.8-0.7-0.8-0.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.10.2-0.2-0.60.5-0.3-0.1-0.2-0.3-0.2-0.4-0.3
Pavlov. Cond. response bias0.10.10.40.30.6-0.6-0.40.30.10.20.20.20.30.20.0
Time in closed arm before self-admin0.40.51.1-0.7-1.11.0-0.00.1-0.5-0.4-0.6-0.7-0.7-0.9-0.8
Time in closed arm after self-admin0.80.92.3-1.4-1.51.5-0.00.2-0.5-0.2-0.8-0.8-1.1-0.8-0.8
Time in open arm before self-admin0.20.20.6-0.7-0.30.3-0.70.80.30.40.10.20.20.3-0.1
Time in open arm after self-admin0.90.93.31.71.8-1.8-0.90.8-0.4-0.5-0.3-0.2-0.2-0.00.0
Bone: periosteal estimation0.30.51.7-1.2-1.31.30.8-0.80.20.5-0.00.1-0.1-0.0-0.2
Bone: periosteal perimeter1.01.73.2-1.8-1.71.71.3-1.21.21.41.01.11.01.00.8
Bone: post-yield work0.20.41.50.0-0.30.31.2-1.20.50.30.30.50.20.40.5
Progressive ratio test 1 active lever presses0.40.51.30.30.3-0.3-0.30.3-1.0-0.7-1.1-1.0-1.1-0.8-0.5
Progressive ratio test 1 breakpoint0.40.51.20.30.3-0.3-0.30.3-1.0-0.7-1.1-1.0-1.1-0.9-0.6
Progressive ratio test 1 inactive lever presses0.10.20.5-0.20.2-0.3-0.60.6-0.4-0.3-0.7-0.4-0.3-0.3-0.3
Progressive ratio test 2 active lever presses0.70.91.7-0.30.1-0.1-0.80.8-1.1-1.1-1.2-1.2-1.0-1.3-1.1
Progressive ratio test 2 breakpoint0.70.81.6-0.30.1-0.2-0.70.7-1.1-1.0-1.2-1.2-0.9-1.3-1.1
Progressive ratio test 2 inactive lever presses0.30.40.8-0.9-0.30.3-0.60.6-0.6-0.5-0.7-0.7-0.5-0.9-0.8
Incentive Sensitization - Responses0.30.51.3-0.60.3-0.3-1.21.1-0.6-0.6-0.7-0.6-0.2-0.6-0.8
Incentive Sensitization - Breakpoint0.40.51.3-0.50.4-0.4-1.11.1-0.6-0.7-0.7-0.6-0.2-0.7-0.8
Sum of active levers in priming session hrs 5-60.50.51.4-1.2-0.90.91.0-1.00.30.50.40.30.30.10.3
Progressive ratio0.30.40.90.80.8-0.8-0.90.9-0.6-0.4-0.2-0.5-0.5-0.2-0.5
Food seeking constrained by brief footshock0.20.20.7-0.7-0.60.60.2-0.10.30.40.40.40.10.60.8
Seeking ratio, punishment vs. effort0.20.31.2-0.9-1.11.10.6-0.60.20.1-0.10.0-0.1-0.10.3
Retroperitoneal fat weight2.711.613.3-3.6-3.53.53.4-3.53.43.73.53.33.23.13.1
Reaction time number correct0.20.31.1-1.1-0.80.80.4-0.3-0.2-0.2-0.4-0.3-0.5-0.4-0.5
Reaction time mean minus median1.43.46.12.22.0-2.0-2.52.4-1.7-1.2-1.6-1.7-1.6-1.3-1.5
Reaction time mean minus median AUC1.33.46.92.42.0-2.0-2.62.6-1.6-1.1-1.4-1.5-1.4-0.9-1.4
Reaction time num false alarms0.20.30.50.50.4-0.4-0.60.6-0.6-0.6-0.4-0.6-0.7-0.5-0.2
Reaction time num false alarms AUC0.00.00.20.10.0-0.0-0.00.00.0-0.00.10.0-0.10.10.4
Reaction time trials correct on left0.20.31.1-1.1-0.80.80.4-0.3-0.2-0.2-0.4-0.3-0.5-0.4-0.5
Reaction time trials on left0.20.31.0-1.0-0.70.70.3-0.3-0.2-0.3-0.5-0.3-0.5-0.5-0.5
Reaction time mean1.32.15.72.32.4-2.4-1.81.7-0.7-0.7-0.6-0.5-0.3-0.1-0.5
Reaction time mean AUC1.21.85.12.12.3-2.3-1.81.7-0.6-0.6-0.5-0.5-0.3-0.1-0.4
Median of all reaction times0.91.24.31.82.1-2.1-1.21.1-0.1-0.3-0.00.10.30.40.0
Reaction time omissions0.50.71.51.21.1-1.1-1.11.1-0.6-0.4-0.6-0.6-0.6-0.0-0.2
Reaction time false alarm rate0.10.10.40.40.2-0.2-0.10.00.20.20.40.30.20.30.6
Reaction time premature initiation rate5.57.611.23.33.1-3.1-3.03.0-2.7-2.7-2.5-2.6-2.7-2.1-2.2
Reaction time premature initiations3.76.68.02.52.5-2.5-2.72.7-2.6-2.6-2.7-2.6-2.8-2.2-2.3
Std. dev. reaction times1.42.64.92.22.1-2.1-2.22.1-1.2-0.9-1.1-1.2-1.0-0.8-1.1
Reaction time trials completed0.20.31.0-1.0-0.70.70.3-0.3-0.2-0.3-0.5-0.3-0.5-0.5-0.5
Reaction time trials AUC0.20.31.2-1.1-0.90.90.5-0.4-0.0-0.1-0.3-0.2-0.3-0.3-0.3
Run reversals in cocaine runway, females0.50.51.31.11.1-1.1-0.70.7-0.4-0.4-0.5-0.3-0.4-0.1-0.0
Run reversals in cocaine runway, males0.50.51.2-0.8-0.90.91.1-1.10.40.60.00.4-0.00.60.9
Latency to leave start box in cocaine runway3.64.17.1-1.0-1.51.50.9-0.92.22.52.72.32.32.62.6
Latency to leave start box in cocaine runway, F4.85.58.8-1.8-2.02.01.6-1.62.42.83.02.52.52.62.8
Latency to leave start box in cocaine runway, M0.10.10.70.4-0.20.2-0.70.9-0.00.1-0.1-0.0-0.00.2-0.2
Std. dev. time between licks in bursts0.00.00.20.50.0-0.00.1-0.2-0.1-0.10.1-0.10.0-0.10.2
Total sessions with >9 infusions0.10.10.2-0.4-0.10.10.5-0.5-0.10.1-0.1-0.0-0.20.30.4
Short access day 1 total inactive lever presses0.20.31.8-1.3-0.90.9-0.10.20.10.40.10.00.2-0.10.2
Short access day 10 total inactive lever presses0.20.41.3-1.1-0.50.50.2-0.20.80.60.70.71.00.30.5
Short access day 1 total infusions0.00.10.2-0.10.2-0.3-0.20.1-0.4-0.1-0.3-0.2-0.40.00.2
Short access day 10 total infusions0.40.50.80.70.8-0.8-0.60.6-0.8-0.6-0.9-0.7-0.9-0.2-0.5
Short access total infusions0.30.30.90.70.9-0.9-0.40.4-0.6-0.5-0.5-0.4-0.5-0.1-0.1
Short access day 1 locomotion0.10.20.3-0.20.3-0.30.0-0.0-0.6-0.5-0.6-0.5-0.6-0.5-0.3
Short access day 10 total locomotion0.30.61.4-0.9-1.01.01.2-1.20.50.70.40.40.30.50.6
Short access total locomotion0.10.10.10.20.3-0.30.3-0.3-0.3-0.3-0.3-0.3-0.2-0.2-0.1
One hour access (0.3 mA shock)2.52.94.21.41.4-1.4-1.51.4-1.9-1.8-2.1-1.9-1.7-1.9-1.7
Compulsive drug intake0.81.02.61.61.5-1.5-1.11.1-0.7-0.8-0.5-0.6-0.7-0.3-0.5
One hour access (shock baseline)0.40.61.30.20.3-0.3-0.10.1-0.9-0.9-1.1-0.9-0.7-1.1-1.0
Social response proportion1.01.12.5-0.5-0.10.1-1.11.1-1.0-0.7-1.2-1.2-1.1-1.6-1.5
Social responses1.52.03.50.60.8-0.8-1.81.9-1.4-1.0-1.6-1.6-1.6-1.5-1.6
Social time0.20.31.20.91.1-1.1-0.40.4-0.1-0.0-0.00.10.2-0.1-0.5
Soleus weight0.61.93.9-2.0-1.91.91.3-1.31.21.51.11.00.81.01.1
Bone: stiffness0.10.10.20.3-0.50.50.4-0.30.20.20.30.10.10.0-0.2
Tibialis anterior weight0.62.06.6-2.5-2.62.61.4-1.30.50.90.20.2-0.0-0.10.3
Time to tail flick, vehicle, before self-admin0.40.40.7-0.3-0.30.30.6-0.80.80.80.70.80.80.60.5
Time to tail flick, vehicle, after self-admin0.71.02.2-1.2-1.51.51.0-1.00.90.80.90.70.80.70.5
Time to tail flick, test, before self-admin0.60.72.5-1.1-1.61.60.8-0.70.20.40.10.1-0.10.1-0.1
Time to tail flick, test, after self-admin0.50.51.4-0.0-0.20.20.8-0.80.80.70.80.80.51.11.2
Delta time to tail flick, vehicle, before/after SA1.31.22.1-1.0-1.11.21.4-1.31.10.91.21.11.01.00.9
Delta time to tail flick, test, before/after SA0.40.41.61.01.3-1.3-0.50.5-0.2-0.40.0-0.0-0.10.10.2
Tibia length1.13.08.8-2.5-3.03.01.8-1.71.11.40.90.80.80.60.6
Ambulatory time before self-admin0.20.30.50.00.2-0.20.7-0.70.50.30.60.60.60.60.6
Ambulatory time after self-admin0.20.31.61.30.5-0.50.00.0-0.4-0.3-0.4-0.4-0.7-0.1-0.1
Bone: tissue strength0.70.72.7-1.7-1.31.30.7-0.60.60.40.30.50.40.20.3
Total heroin consumption0.40.51.81.31.3-1.3-0.0-0.1-0.3-0.3-0.3-0.2-0.0-0.1-0.2
Bone: trabecular number2.54.28.6-2.7-2.92.92.7-2.51.61.71.31.40.91.21.2
Bone: trabecular spacing0.20.20.50.40.6-0.5-0.30.20.40.20.50.50.70.60.2
Bone: trabecular thickness3.34.26.8-2.3-2.42.42.6-2.61.81.81.61.71.41.61.7
Bone: trabecular tissue density1.11.62.9-1.1-0.90.90.6-0.61.41.41.61.41.31.51.7
Water consumed over 24 hours1.01.32.40.60.2-0.2-0.80.9-1.3-1.3-1.5-1.4-1.5-1.5-1.3
Number of responses in last shaping day0.20.20.4-0.4-0.20.20.7-0.60.30.30.20.30.20.50.6