Med4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Med4	0.04	0.02	5.2e-04	0.03	0.02	0.02	0.02	5.6e-04	1.5e-03	3.5e-03	2.6e-03
2	Brain	gene expression	Med4	0.08	0.04	7.5e-08	0.08	0.08	0.07	0.08	5.9e-08	4.1e-08	1.7e-07	5.4e-08
3	PL	gene expression	Med4	0.03	0.02	2.3e-03	0.01	0.01	0	0.01	2.0e-02	1.4e-02	1.1e-01	4.0e-02
4	Liver	gene expression	Med4	0.08	0.05	8.0e-07	0.05	0.05	0.04	0.04	3.3e-06	3.6e-06	1.1e-05	1.2e-05
5	pVTA	gene expression	Med4	0.16	0.08	2.8e-05	0.14	0.11	0.12	0.13	1.0e-06	1.7e-05	7.0e-06	3.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.5	0.8	1.9	-0.6	0.1	-0.4	1.2	1.4
Area under the delay curve	0.9	0.9	2.3	-0.7	-0.2	-0.5	1.3	1.5
BMI with tail	0.0	0.1	0.3	0.5	0.4	0.2	-0.1	-0.1
BMI without tail	0.2	0.4	1.4	-0.4	1.2	0.8	0.0	-0.0
Body weight	0.4	1.5	2.0	-1.4	1.4	1.3	-1.0	-1.0
Weight adjusted by age	0.8	0.9	2.4	0.0	-1.5	-1.1	0.6	0.5
Bone surface	0.6	1.1	2.3	-0.7	-0.2	-0.6	1.5	1.5
Bone volume	0.9	1.5	3.4	-0.4	-0.3	-0.9	1.8	1.8
Breakpoint value in progressive ratio session	0.6	0.7	1.8	1.3	-0.1	-0.0	-0.8	-1.0
Number of licking bursts	1.2	1.4	2.0	-0.1	1.4	1.3	-1.2	-1.3
Context. condit. distance diff. score	1.7	2.1	2.8	0.9	1.7	1.4	-1.6	-1.5
Locomotion velocity, session 1	1.5	1.6	2.5	0.6	-1.6	-1.5	1.2	1.3
Locomotion distance, session 1	0.8	1.0	2.0	-0.6	-0.5	-0.7	1.3	1.4
Locomotion velocity, session 2	0.4	0.5	0.8	-0.5	-0.5	-0.5	0.9	0.8
Locomotion distance, session 2	1.8	2.6	4.9	-0.8	-0.9	-1.3	2.2	2.2
Locomotion velocity, session 3	0.1	0.1	0.2	0.5	0.2	0.1	-0.2	-0.5
Locomotion distance, session 3	0.5	0.5	0.8	0.2	0.9	0.7	-0.6	-0.9
Stereotopy head waving bouts, day 3	0.4	0.4	1.1	0.8	-1.0	-0.7	-0.0	0.0
Stereotopy head waving duration, day 3	0.8	1.0	1.9	0.6	-1.4	-1.2	0.8	0.8
Locomotion velocity, session 7	4.2	4.6	7.2	0.2	2.7	2.4	-2.1	-2.3
Locomotion distance, session 7	2.0	2.5	4.1	0.5	2.0	1.7	-1.5	-1.8
Stereotopy head waving bouts, day 7	0.3	0.3	0.4	-0.5	-0.5	-0.4	0.7	0.7
Stereotopy head waving duration, day 7	0.1	0.2	0.5	-0.0	-0.7	-0.4	0.1	0.3
Locomotion velocity, session 8	0.1	0.1	0.4	0.3	0.6	0.4	-0.2	-0.2
Locomotion distance, session 8	0.3	0.4	1.2	-0.5	1.1	0.5	0.4	0.5
Degree of sensitization distance	0.6	0.6	0.9	0.4	1.0	0.8	-0.8	-0.8
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.5	0.1	0.2	-0.1	-0.0
Conditioned locomotion	0.2	0.3	0.5	0.5	0.1	0.2	-0.7	-0.7
Cocaine response after cond. corrected	1.1	1.2	4.0	2.0	-0.8	-0.5	-0.8	-0.8
Cocaine response after cond. not corrected	0.3	0.3	1.3	1.1	-0.4	-0.3	-0.2	-0.3
Cocaine response before conditioning	1.4	1.7	5.2	-2.3	1.2	0.8	0.9	0.7
Saline control response	0.7	0.9	1.5	-0.6	1.2	1.1	-0.8	-0.9
Bone: connectivity density	0.5	0.8	1.2	-1.1	1.1	1.0	-0.7	-0.5
Bone: cortical apparent density	1.5	2.0	3.8	1.4	0.3	0.7	-1.9	-2.0
Bone: cortical area	0.6	0.9	1.8	-0.0	-0.3	-0.8	1.3	1.4
Bone: cortical porosity	0.8	0.9	3.1	-1.8	0.4	0.2	0.8	0.8
Bone: cortical porosity	1.0	1.0	2.5	-1.6	0.2	-0.1	1.1	1.2
Bone: cortical thickness	0.1	0.2	0.5	-0.3	0.7	0.5	-0.3	-0.3
Bone: cortical thickness	0.2	0.3	0.3	0.6	0.6	0.5	-0.5	-0.6
Bone: cortical tissue density	1.5	2.0	3.9	1.4	0.3	0.7	-1.9	-2.0
Condit. Reinf. active minus inactive responses	0.4	0.5	1.5	-1.2	0.3	0.6	-0.6	-0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	0.5	-0.8	-0.4	-0.3	-0.1
Condit. Reinf. active responses	1.3	1.6	4.5	-2.1	1.1	1.2	-0.6	-0.4
Condit. Reinf. inactive responses	2.4	2.9	7.6	-2.8	1.9	1.7	-0.3	-0.2
Incentive salience index mean	2.0	2.4	7.6	-2.8	1.3	1.5	-0.7	-0.4
Condit. Reinf. lever presses	3.6	4.9	13.5	-3.7	2.2	2.2	-0.9	-0.6
Condit. Reinf. active minus inactive responses	0.6	0.7	0.9	-0.6	0.8	0.9	-1.0	-0.8
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.1	0.2	0.0	0.1	0.2
Condit. Reinf. active responses	0.6	0.9	1.4	-0.9	1.2	1.1	-0.7	-0.6
Condit. Reinf. inactive responses	1.2	1.4	2.2	-1.1	1.5	1.4	-0.9	-0.9
Condit. Reinf. lever presses	1.1	1.5	4.9	-2.2	0.6	0.3	0.9	1.1
Condit. Reinf. lever reinforcers received	0.6	0.8	1.4	-1.1	1.2	1.1	-0.5	-0.3
Conditioned reinforcement - actives	0.4	0.4	1.3	1.1	0.1	0.1	-0.5	-0.6
Conditioned reinforcement - inactives	1.1	1.2	2.3	-1.5	1.4	1.2	-0.5	-0.3
Conditioned locomotion	0.5	0.6	1.4	-0.3	-0.3	-0.6	1.1	1.2
Patch foraging indifference point 0 sec	2.4	3.9	9.9	-3.1	2.2	2.1	-0.4	-0.4
Patch foraging indifference point AUC	1.8	2.1	3.0	1.7	-1.3	-1.5	1.1	1.5
Delay disc. indifference point, 0s delay	0.7	0.7	1.2	-0.8	-0.7	-0.6	0.9	1.1
Delay disc. indifference point, 16s delay	0.4	0.4	1.1	-0.2	-0.2	-0.4	0.9	1.0
Delay disc. indifference point, 2s delay	3.5	3.8	6.9	0.2	-2.0	-2.0	2.1	2.6
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	0.2	-0.3	-0.5	0.7	0.7
Delay disc. indifference point, 4s delay	1.1	1.2	2.2	0.2	-1.0	-1.1	1.2	1.5
Delay disc. indifference point, 8s delay	0.3	0.4	0.8	-0.9	0.8	0.5	0.2	0.3
Indifference point function ln k	1.6	2.3	4.0	-2.0	1.5	1.6	-1.1	-1.2
Indifference point function log k	1.6	2.3	4.0	-2.0	1.5	1.6	-1.1	-1.2
Patch foraging total patch changes 0 sec	2.3	3.7	8.8	-3.0	2.2	2.0	-0.6	-0.5
Patch foraging total patch changes 12 sec	0.5	0.6	1.5	-1.2	0.5	0.3	0.6	0.9
Patch foraging total patch changes 18 sec	0.6	0.7	1.4	-0.2	1.2	1.1	-0.8	-0.5
Patch foraging total patch changes 24 sec	0.6	0.7	2.0	-1.4	1.0	0.7	0.3	0.4
Patch foraging total patch changes 6 sec	2.0	2.9	4.4	-1.0	2.1	2.1	-1.6	-1.5
Patch foraging time to switch 0 sec	0.0	0.0	0.1	-0.1	-0.1	-0.0	-0.0	-0.2
Patch foraging water rate 0 sec	0.4	0.7	1.4	-0.8	1.2	1.0	-0.5	-0.3
Patch foraging water rate 12 sec	0.3	0.5	1.2	-0.0	0.3	0.7	-1.1	-0.9
Patch foraging water rate 18 sec	0.3	0.5	0.8	0.4	0.5	0.6	-0.9	-0.9
Patch foraging water rate 24 sec	1.8	2.6	3.9	0.6	1.5	1.6	-2.0	-1.9
Patch foraging water rate 6 sec	0.1	0.1	0.3	0.5	-0.3	-0.3	-0.0	0.1
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.7	-0.8	-0.0	0.5	-0.9	-0.7
Distance traveled before self-admin	2.2	2.4	3.2	0.6	-1.8	-1.8	1.6	1.6
Distance traveled after self-admin	2.6	2.9	4.2	2.1	-2.0	-1.9	1.1	1.2
Extensor digitorum longus weight	4.3	17.1	26.7	4.2	-5.2	-4.8	3.0	3.0
Bone: elastic displacement	0.0	0.0	0.1	-0.4	-0.1	0.0	-0.1	-0.2
Bone: elastic work	0.9	1.2	2.4	-1.0	-0.5	-0.8	1.5	1.3
Bone: endosteal estimation	1.2	2.7	5.3	-0.1	-1.2	-1.6	2.3	2.1
Bone: endosteal perimeter	1.5	3.0	5.4	-0.2	-1.4	-1.6	2.2	2.3
Epididymis fat weight	1.5	3.4	4.6	-2.1	2.1	2.1	-1.4	-1.2
Delta time in closed arm before/after self-admin	0.7	0.6	1.5	-0.6	-0.4	-0.5	1.2	1.0
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.2	0.3	0.2	0.0	0.0
Diff in mean of infusions in LGA sessions	1.5	1.7	3.2	1.8	-0.1	0.2	-1.6	-1.6
Delay discount exponential model param	1.1	1.1	2.7	0.7	0.2	0.6	-1.4	-1.6
Extinction: sum of active levers before priming	0.9	0.9	1.6	-0.2	1.3	1.1	-0.9	-0.8
Active lever presses in extinction session 6	1.2	1.2	1.6	-0.0	1.2	1.2	-1.2	-1.3
Bone: final force	0.3	0.5	1.3	-1.1	0.9	0.6	0.3	0.2
Bone: final moment	0.3	0.5	1.6	-1.2	0.7	0.4	0.6	0.4
Food consumed during 24 hour testing period	0.8	1.0	2.2	-0.9	-0.2	-0.5	1.3	1.5
Glucose	0.5	0.8	2.6	1.6	-0.1	-0.6	0.7	0.6
Heart weight	0.2	0.2	0.5	-0.5	-0.2	-0.3	0.7	0.5
Delay discount hyperbolic model param	1.6	1.7	3.8	0.5	0.7	1.0	-1.7	-2.0
Intermittent access intake day 1-15 change	3.2	3.2	4.3	-1.2	2.0	2.1	-1.9	-1.6
Intermittent access intake escalation	3.1	3.0	4.1	-0.8	1.9	2.0	-2.0	-1.7
Intermittent access intake escalation 2	0.9	0.9	1.6	-0.4	0.9	1.1	-1.2	-1.0
Intermitt. access day 1 inactive lever presses	2.6	2.8	4.3	-0.7	1.4	1.7	-2.1	-2.0
Intermitt. access day 15 inactive lever presses	1.1	1.2	1.5	-1.1	1.2	1.2	-1.0	-0.8
Intermitt. access escalation Index	0.4	0.3	0.7	0.9	-0.6	-0.6	0.4	0.4
Intermittent access day 1 total infusions	0.6	0.6	1.8	-0.5	1.4	1.0	-0.4	-0.2
Intermittent access day 15 total infusions	2.6	2.9	4.4	-0.8	2.1	2.0	-1.7	-1.5
Intermittent access terminal intake (last 3 days)	1.2	1.3	2.2	-0.4	1.5	1.3	-1.2	-0.9
Intermittent access total infusions	2.1	2.3	4.3	-0.7	2.1	1.8	-1.4	-1.2
Intermittent access day 1 locomotion	1.7	1.8	3.4	-1.4	1.9	1.6	-0.7	-0.7
Intermittent access day 15 total locomotion	1.1	1.2	2.0	-0.4	1.4	1.3	-1.0	-1.1
Intermittent access total locomotion	1.3	1.5	2.9	-1.1	1.7	1.5	-0.8	-0.7
Intermittent access standard deviation	1.2	1.2	1.9	-0.1	1.2	1.2	-1.4	-1.2
Left kidney weight	1.0	2.8	9.4	-3.1	1.6	1.4	-0.1	-0.1
Right kidney weight	1.9	5.4	20.4	-4.5	1.9	1.7	0.2	0.2
Cocaine induced anxiety	1.5	1.7	2.2	-0.9	-1.5	-1.3	1.3	1.5
Post-drug Anxiety	0.6	0.7	1.3	-1.2	0.4	0.8	-0.9	-0.7
Baseline Anxiety	2.6	2.8	4.1	-0.6	2.0	2.0	-1.6	-1.7
Tail length	0.6	1.8	5.6	-2.4	1.5	1.1	0.3	0.3
Length with tail	0.4	1.4	2.8	-1.7	0.9	1.1	-1.1	-1.0
Length without tail	0.2	0.4	0.8	0.1	-0.7	-0.2	-0.9	-0.9
Times rat made contact with spout	1.7	1.9	4.5	-0.9	2.1	1.7	-0.8	-0.8
Lifetime Intake	1.3	1.5	3.1	-0.6	1.8	1.5	-1.0	-0.8
Liver weight, left	0.1	0.2	0.2	0.4	-0.4	-0.1	-0.5	-0.5
Liver weight, right	0.1	0.2	0.9	0.9	-0.3	-0.4	0.2	0.2
Locomotor activity	2.8	4.5	6.3	-1.0	-2.2	-2.2	2.5	2.4
Locomotor testing distance	1.1	1.8	2.7	-1.6	-1.0	-0.9	1.6	1.5
Locomotor testing rearing	1.3	1.9	4.3	-2.1	-0.7	-0.7	1.5	1.4
Locomotion in novel chamber	0.6	0.7	1.6	-0.7	0.1	-0.3	1.3	1.2
Locomotion in novel chamber post-restriction	0.8	0.9	1.5	0.6	-0.7	-0.9	1.1	1.2
Fecal boli incidents, locomotor time 1	0.4	0.5	1.1	-0.1	-0.1	-0.5	1.1	1.0
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	0.5	-0.8	-0.2	-0.8	-0.4
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.6	-1.3	0.6	0.6	-0.1	-0.4
Bouts of movement, locomotor time 1	0.6	0.6	1.5	1.2	-0.5	-0.2	-0.6	-1.0
Total resting periods, locomotor time 1	0.6	0.7	2.0	1.4	-0.6	-0.4	-0.5	-0.8
Rest time, locomotor task time 1	1.8	2.0	2.9	1.3	-1.7	-1.7	1.3	0.9
Distance moved, locomotor task time 1	1.7	1.9	2.4	-1.0	1.4	1.6	-1.5	-1.3
Vertical activity count, locomotor time 1	0.1	0.1	0.2	-0.0	-0.4	-0.3	-0.1	-0.1
Time >=10cm from walls, locomotor time 2	1.0	1.1	2.1	0.6	-1.5	-1.3	0.8	0.7
Bouts of movement, locomotor time 2	0.7	0.7	2.9	1.7	-0.5	-0.4	-0.4	-0.5
Total resting periods, locomotor time 2	0.6	0.6	2.6	1.6	-0.4	-0.4	-0.3	-0.4
Rest time, locomotor task time 2	0.4	0.4	1.5	1.2	-0.2	-0.5	0.5	0.1
Distance moved, locomotor task time 2	0.8	0.9	1.9	-1.4	0.8	1.0	-0.7	-0.6
Vertical activity count, locomotor time 2	1.0	1.1	1.8	0.4	-1.3	-1.3	1.0	1.0
Light reinforcement 1	1.5	2.8	5.2	-0.9	2.3	2.1	-1.4	-1.3
Light reinforcement 2	1.4	1.9	2.8	0.7	1.5	1.4	-1.7	-1.5
Bone: marrow area	1.2	2.6	5.2	-0.3	-1.1	-1.5	2.3	2.1
Bone: maximum diameter	1.0	1.8	2.7	0.8	-1.1	-1.4	1.6	1.7
Bone: maximum force	0.5	0.8	2.0	-0.8	0.1	-0.4	1.4	1.2
Bone: maximum moment	0.7	1.2	2.5	-1.0	-0.0	-0.5	1.6	1.4
Mean time between licks in bursts	0.1	0.1	0.1	-0.3	0.1	0.0	0.4	0.3
Mean num. licks in bursts	0.2	0.2	0.5	-0.2	0.1	-0.2	0.6	0.7
Cd content in liver	0.6	0.6	1.0	0.1	0.7	0.8	-1.0	-1.0
Co content in liver	3.2	3.7	9.3	3.1	-1.9	-1.9	0.9	1.0
Cu content in liver	0.8	0.9	2.1	1.4	-1.2	-1.0	0.1	0.2
Fe content in liver	0.3	0.3	0.5	-0.7	0.6	0.7	-0.4	-0.3
K content in liver	0.5	0.5	0.9	-0.6	1.0	0.8	-0.5	-0.4
Mg content in liver	0.1	0.1	0.2	0.3	0.0	-0.2	0.4	0.5
Mn content in liver	0.3	0.4	0.7	0.4	-0.2	-0.5	0.8	0.8
Na content in liver	2.8	3.0	4.5	-1.7	-1.2	-1.3	2.1	2.1
Rb content in liver	1.1	1.4	2.7	0.1	0.9	1.1	-1.6	-1.5
Se content in liver	1.4	1.8	2.4	-0.5	-1.5	-1.4	1.4	1.5
Sr content in liver	0.7	0.7	1.1	0.1	-0.8	-0.8	1.0	1.0
Zn content in liver	1.1	1.2	1.7	-0.7	-1.1	-1.1	1.2	1.3
Bone: minimum diameter	1.1	2.0	4.0	-0.7	-0.6	-1.0	2.0	2.0
Time in familiar zone, hab. session 1	0.4	0.3	0.9	-0.6	0.9	0.7	-0.1	0.0
Time in novel zone, hab. session 1	2.3	2.2	5.9	2.4	-1.8	-1.4	-0.0	-0.2
Total zone transitions, hab. session 1	0.7	0.9	1.6	0.0	-0.9	-1.0	1.1	1.3
Total locomotion distance, hab. session 1	0.7	1.0	1.8	-0.9	-0.6	-0.7	1.2	1.3
Locomotion velocity, hab. session 1	1.2	1.8	3.0	-1.7	-0.4	-0.6	1.6	1.7
Time in familiar zone, hab. session 2	0.7	0.7	2.4	1.6	-0.7	-0.7	0.0	-0.3
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.4	-0.0	-0.1	0.3	0.6
Total zone transitions, hab. session 2	0.8	1.1	1.5	-0.2	-1.2	-1.1	1.1	1.2
Total locomotion distance, hab. session 2	0.4	0.6	1.0	-0.3	-0.8	-0.7	0.8	1.0
Locomotion velocity, hab. session 2	0.9	1.2	2.2	-0.4	-1.1	-1.0	1.2	1.5
Novel to familiar place preference ratio	0.7	0.7	1.2	-0.9	1.1	1.0	-0.5	-0.3
Novelty place preference	0.8	0.9	1.5	-1.0	1.2	1.1	-0.6	-0.4
Time in novel zone, NPP test	0.5	0.5	0.9	-0.8	0.9	0.9	-0.3	-0.2
Total zone transitions, NPP test	0.1	0.2	0.7	-0.8	0.1	-0.0	0.5	0.4
Total locomotion distance, NPP test	0.4	0.6	2.0	-1.4	0.7	0.5	0.3	0.4
Locomotion velocity, NPP test	0.6	0.9	2.5	-1.6	1.0	0.9	-0.1	-0.0
Intraocular pressure	0.9	1.2	1.7	-0.5	1.3	1.3	-1.0	-1.2
Delta distance traveled before/after self-admin	0.9	1.0	4.1	2.0	-0.5	-0.4	-0.5	-0.3
Delta ambulatory time before/after self-admin	0.5	0.5	2.2	1.5	-0.3	-0.3	-0.5	-0.3
Parametrial fat weight	0.9	1.7	2.2	-0.2	1.4	1.5	-1.5	-1.4
Pavlov. Cond. lever latency	2.5	3.1	4.8	2.2	-2.0	-2.0	1.3	1.0
Pavlov. Cond. magazine entry latency	1.0	1.3	1.8	-1.0	1.3	1.3	-1.1	-0.9
Pavlov. Cond. change in total contacts	1.0	1.1	1.8	-1.3	1.1	1.2	-0.8	-0.6
Pavlov. Cond. index score	2.2	2.8	4.1	-2.0	2.0	1.9	-1.3	-0.9
Pavlov. Cond. latency score	2.8	3.6	5.3	-2.3	2.2	2.2	-1.4	-1.0
Pavlov. Cond. lever contacts	2.6	3.1	4.9	-2.2	2.0	2.0	-1.3	-1.0
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	0.5	-0.7	-0.6	0.4	0.2
Pavlov. Cond. intertrial magazine entries	0.7	0.8	3.1	-1.7	0.7	0.7	-0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	3.4	-1.8	1.7	1.6	-0.9	-0.7
Pavlov. Cond. response bias	0.8	1.0	1.2	-1.1	1.1	1.1	-0.9	-0.7
Pavlov. Cond. lever latency	1.0	1.3	2.3	1.5	0.3	0.4	-1.3	-1.5
Pavlov. Cond. magazine entry latency	1.4	1.6	2.8	-1.6	-0.0	-0.4	1.6	1.7
Pavlov. Cond. change in total contacts	1.5	2.0	2.8	-0.1	-1.6	-1.6	1.5	1.7
Pavlov. Cond. index score	1.6	2.0	3.8	-1.4	-0.7	-0.9	1.7	2.0
Pavlov. Cond. latency score	1.6	2.0	3.6	-1.6	-0.6	-0.8	1.6	1.9
Pavlov. Cond. lever contacts	1.5	2.1	3.8	-1.7	-0.5	-0.7	1.7	2.0
Pavlov. Cond. magazine entry number	1.2	1.5	2.7	1.5	-0.0	0.4	-1.5	-1.7
Pavlov. Cond. intertrial magazine entries	2.5	3.3	6.3	-1.4	2.5	2.2	-1.2	-1.4
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	3.9	-1.3	-0.7	-1.0	1.8	2.0
Pavlov. Cond. response bias	2.0	2.8	5.4	-1.6	-0.7	-1.0	2.1	2.3
Time in closed arm before self-admin	0.1	0.1	0.3	-0.1	-0.3	-0.3	0.3	0.6
Time in closed arm after self-admin	0.2	0.2	0.3	0.1	-0.5	-0.5	0.4	0.4
Time in open arm before self-admin	0.4	0.4	1.1	1.1	-0.7	-0.7	0.2	0.2
Time in open arm after self-admin	0.2	0.2	0.3	0.3	-0.4	-0.5	0.5	0.6
Bone: periosteal estimation	1.1	2.2	4.4	-0.0	-0.9	-1.4	2.1	2.0
Bone: periosteal perimeter	0.8	1.3	2.6	0.1	-0.8	-1.1	1.5	1.6
Bone: post-yield work	0.1	0.2	0.6	0.1	0.8	0.3	0.2	0.2
Progressive ratio test 1 active lever presses	0.6	0.6	0.9	0.6	1.0	0.7	-0.8	-0.8
Progressive ratio test 1 breakpoint	0.7	0.8	1.0	0.7	1.0	0.8	-0.9	-0.9
Progressive ratio test 1 inactive lever presses	6.0	6.6	8.2	-0.6	2.8	2.9	-2.8	-2.9
Progressive ratio test 2 active lever presses	1.1	1.2	2.4	0.5	1.5	1.2	-1.0	-0.9
Progressive ratio test 2 breakpoint	1.2	1.3	3.0	0.0	1.7	1.4	-0.9	-0.9
Progressive ratio test 2 inactive lever presses	1.4	1.6	3.0	-0.8	1.7	1.5	-1.1	-1.1
Incentive Sensitization - Responses	0.5	0.5	1.5	-0.4	1.2	0.8	-0.1	0.0
Incentive Sensitization - Breakpoint	0.7	0.7	2.1	-0.7	1.4	1.0	-0.2	-0.1
Sum of active levers in priming session hrs 5-6	1.1	1.1	4.4	2.1	-0.6	-0.5	-0.5	-0.3
Progressive ratio	0.5	0.6	1.7	1.3	0.3	0.2	-0.8	-0.8
Food seeking constrained by brief footshock	3.5	4.3	14.8	3.8	-1.3	-0.9	-1.6	-1.4
Seeking ratio, punishment vs. effort	0.3	0.4	1.0	0.6	-1.0	-0.7	0.2	0.3
Retroperitoneal fat weight	0.8	2.5	3.5	-0.7	1.5	1.7	-1.9	-1.9
Reaction time number correct	0.8	1.2	4.6	2.2	-0.9	-0.7	-0.2	-0.3
Reaction time mean minus median	0.3	0.4	0.9	-1.0	-0.6	-0.5	0.5	0.4
Reaction time mean minus median AUC	0.2	0.2	0.5	-0.7	-0.2	-0.3	0.5	0.5
Reaction time num false alarms	0.4	0.6	1.6	-0.4	-0.3	-0.5	1.3	0.9
Reaction time num false alarms AUC	0.5	0.7	1.8	-0.5	-0.1	-0.4	1.3	1.0
Reaction time trials correct on left	0.8	1.2	4.6	2.2	-0.9	-0.7	-0.2	-0.3
Reaction time trials on left	0.8	1.1	4.4	2.1	-0.8	-0.6	-0.2	-0.4
Reaction time mean	0.8	1.1	1.4	-1.0	-1.0	-0.9	1.2	1.2
Reaction time mean AUC	1.0	1.4	1.7	-0.9	-1.3	-1.1	1.3	1.3
Median of all reaction times	0.7	1.0	1.3	-0.9	-0.9	-0.9	1.1	1.1
Reaction time omissions	0.3	0.4	1.0	-1.0	0.5	0.6	-0.4	-0.4
Reaction time false alarm rate	0.5	0.7	1.8	-1.3	0.5	0.2	1.0	0.8
Reaction time premature initiation rate	1.4	1.9	4.2	0.8	0.3	0.9	-2.0	-1.9
Reaction time premature initiations	1.6	2.3	4.0	1.9	-0.2	0.4	-2.0	-1.9
Std. dev. reaction times	0.4	0.5	0.7	-0.7	-0.9	-0.7	0.7	0.6
Reaction time trials completed	0.8	1.1	4.4	2.1	-0.8	-0.6	-0.2	-0.4
Reaction time trials AUC	0.8	1.2	4.6	2.2	-0.9	-0.7	-0.1	-0.3
Run reversals in cocaine runway, females	0.2	0.2	0.7	-0.2	0.2	-0.1	0.6	0.8
Run reversals in cocaine runway, males	0.5	0.5	1.1	0.1	-0.2	-0.6	0.9	1.0
Latency to leave start box in cocaine runway	1.0	1.1	2.2	1.0	-1.5	-1.2	0.6	0.5
Latency to leave start box in cocaine runway, F	0.3	0.3	0.8	0.7	-0.9	-0.7	0.1	0.1
Latency to leave start box in cocaine runway, M	0.3	0.2	0.4	0.1	-0.4	-0.5	0.6	0.6
Std. dev. time between licks in bursts	1.0	1.2	4.9	-2.2	0.3	0.3	0.7	0.6
Total sessions with >9 infusions	0.2	0.2	0.5	-0.4	0.7	0.6	-0.3	-0.3
Short access day 1 total inactive lever presses	1.9	2.1	4.8	-1.3	2.2	1.7	-0.7	-0.6
Short access day 10 total inactive lever presses	1.5	1.7	2.6	-0.5	1.4	1.5	-1.6	-1.2
Short access day 1 total infusions	0.2	0.2	0.5	0.2	0.7	0.6	-0.4	-0.4
Short access day 10 total infusions	0.3	0.3	0.6	-0.8	0.7	0.3	0.4	0.5
Short access total infusions	0.9	1.1	2.4	-0.7	1.6	1.3	-0.7	-0.5
Short access day 1 locomotion	0.2	0.3	0.8	-0.9	-0.2	-0.2	0.5	0.5
Short access day 10 total locomotion	0.7	0.8	2.1	-1.4	0.2	-0.1	0.9	1.0
Short access total locomotion	1.1	1.1	3.6	-1.9	1.0	1.0	-0.2	-0.1
One hour access (0.3 mA shock)	0.4	0.4	0.9	-0.1	1.0	0.8	-0.7	-0.5
Compulsive drug intake	0.2	0.2	0.7	-0.8	0.2	0.2	0.2	0.3
One hour access (shock baseline)	0.2	0.2	0.9	0.9	0.1	-0.0	-0.4	-0.3
Social response proportion	1.0	1.1	3.5	1.9	-0.7	-0.4	-0.9	-0.8
Social responses	0.2	0.3	0.6	0.3	0.0	0.3	-0.8	-0.7
Social time	0.3	0.4	1.3	-1.1	-0.1	-0.1	0.6	0.7
Soleus weight	2.8	8.1	14.1	3.8	-3.6	-3.2	1.4	1.3
Bone: stiffness	0.3	0.4	0.9	-1.0	0.5	0.2	0.7	0.5
Tibialis anterior weight	2.7	9.3	13.7	2.8	-3.7	-3.6	2.5	2.5
Time to tail flick, vehicle, before self-admin	3.5	3.6	5.3	-1.1	2.3	2.2	-1.9	-1.8
Time to tail flick, vehicle, after self-admin	1.9	2.0	3.4	1.8	0.2	0.5	-1.7	-1.8
Time to tail flick, test, before self-admin	1.0	1.0	2.2	-1.0	0.0	-0.3	1.2	1.5
Time to tail flick, test, after self-admin	1.8	1.9	2.9	-1.0	1.7	1.7	-1.2	-1.1
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	3.1	1.8	-0.4	-0.2	-0.7	-0.9
Delta time to tail flick, test, before/after SA	1.1	1.0	1.7	0.3	0.9	1.0	-1.2	-1.3
Tibia length	3.8	10.8	28.7	-5.4	3.6	3.3	-1.0	-0.8
Ambulatory time before self-admin	1.0	1.1	1.4	0.4	-1.0	-1.2	1.2	1.2
Ambulatory time after self-admin	2.4	2.6	3.7	1.8	-1.9	-1.9	1.2	1.2
Bone: tissue strength	0.4	0.4	0.9	-1.0	-0.1	-0.1	0.8	0.7
Total heroin consumption	0.3	0.3	0.8	0.9	-0.6	-0.6	0.1	0.1
Bone: trabecular number	0.3	0.4	0.9	-1.0	0.7	0.4	0.4	0.5
Bone: trabecular spacing	0.4	0.6	1.3	0.9	-1.1	-0.9	0.3	0.1
Bone: trabecular thickness	0.4	0.5	1.0	-0.8	1.0	0.5	0.5	0.5
Bone: trabecular tissue density	0.9	1.2	1.9	1.0	-1.4	-1.4	0.9	0.8
Water consumed over 24 hours	0.2	0.3	0.6	-0.2	-0.0	-0.3	0.8	0.8
Number of responses in last shaping day	0.3	0.3	0.5	0.3	-0.6	-0.6	0.7	0.7