Hub : Genes

Med24

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	isoform ratio	XM_006247416.4	0.71	0.11	4.8e-04	-0	0.02	0.05	0.03	5.0e-01	2.9e-02	9.2e-04	7.4e-03
2	BLA	alternative TSS	XM_039086760.1	0.62	0.15	2.5e-03	0.02	0.02	0.05	0.04	2.3e-02	2.4e-02	8.6e-04	3.8e-03
3	BLA	alternative TSS	XM_039086760.1	0.58	0.14	1.1e-03	0.03	0.04	0.06	0.05	1.0e-02	4.0e-03	5.0e-04	1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	3.4	5.8	6.3	-2.5	2.3	2.4
Area under the delay curve	1.3	1.6	1.7	-1.2	1.2	1.3
BMI with tail	0.5	1.7	2.2	1.5	-1.3	-1.1
BMI without tail	0.3	0.9	1.4	1.2	-1.0	-0.6
Body weight	3.6	15.9	18.4	4.3	-4.0	-3.7
Weight adjusted by age	0.1	0.1	0.2	0.4	-0.4	-0.3
Bone surface	0.0	0.0	0.1	-0.1	0.0	0.3
Bone volume	0.1	0.2	0.3	-0.5	0.3	0.5
Breakpoint value in progressive ratio session	0.7	0.9	1.0	0.9	-1.0	-0.9
Number of licking bursts	0.0	0.0	0.0	-0.1	-0.0	0.0
Context. condit. distance diff. score	0.2	0.3	0.4	0.7	-0.4	-0.5
Locomotion velocity, session 1	2.4	2.5	2.9	1.4	-1.7	-1.7
Locomotion distance, session 1	3.3	4.2	4.7	2.1	-2.2	-1.9
Locomotion velocity, session 2	0.4	0.4	0.5	0.6	-0.7	-0.7
Locomotion distance, session 2	0.2	0.3	0.5	0.6	-0.7	-0.4
Locomotion velocity, session 3	0.5	0.6	0.8	-0.6	0.9	0.8
Locomotion distance, session 3	0.0	0.1	0.1	0.3	-0.2	-0.1
Stereotopy head waving bouts, day 3	3.4	4.0	4.2	-2.0	2.0	2.0
Stereotopy head waving duration, day 3	0.3	0.4	0.4	-0.7	0.6	0.6
Locomotion velocity, session 7	1.3	1.5	1.9	1.4	-1.1	-1.1
Locomotion distance, session 7	1.3	1.6	1.7	1.3	-1.2	-1.2
Stereotopy head waving bouts, day 7	4.1	4.6	5.0	-1.9	2.2	2.2
Stereotopy head waving duration, day 7	2.8	3.4	3.9	-1.6	2.0	1.9
Locomotion velocity, session 8	7.9	9.4	9.8	3.1	-3.0	-3.1
Locomotion distance, session 8	1.1	1.6	1.8	1.3	-1.3	-1.2
Degree of sensitization distance	2.3	2.3	2.4	1.5	-1.5	-1.6
Degree of sensitization stereotypy	4.6	5.0	5.4	-2.0	2.3	2.3
Conditioned locomotion	0.5	0.6	0.7	-0.7	0.8	0.7
Cocaine response after cond. corrected	1.2	1.5	1.8	-1.2	1.1	1.3
Cocaine response after cond. not corrected	0.7	0.8	1.0	-1.0	0.7	1.0
Cocaine response before conditioning	0.1	0.1	0.2	0.2	-0.4	-0.4
Saline control response	0.3	0.3	0.4	0.6	-0.6	-0.6
Bone: connectivity density	4.4	6.9	7.3	-2.7	2.5	2.6
Bone: cortical apparent density	4.3	5.9	6.8	-2.6	2.4	2.3
Bone: cortical area	0.2	0.3	0.3	-0.5	0.5	0.5
Bone: cortical porosity	0.2	0.2	0.3	-0.6	0.4	0.4
Bone: cortical porosity	0.0	0.0	0.0	-0.2	0.1	0.1
Bone: cortical thickness	2.1	3.5	3.7	-1.9	1.9	1.8
Bone: cortical thickness	4.3	5.1	5.6	-2.4	2.3	2.1
Bone: cortical tissue density	4.1	5.6	6.5	-2.6	2.3	2.2
Condit. Reinf. active minus inactive responses	1.2	1.4	1.5	-1.2	1.2	1.1
Condit. Reinf. active-inactive response ratio	2.4	2.6	3.0	-1.5	1.7	1.6
Condit. Reinf. active responses	0.5	0.6	0.7	-0.8	0.8	0.7
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.1	-0.3	-0.3
Incentive salience index mean	1.1	1.4	1.6	-1.3	1.2	1.1
Condit. Reinf. lever presses	0.3	0.4	0.6	-0.8	0.6	0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.4	0.2	0.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	-0.6	0.5	0.6
Condit. Reinf. active responses	0.1	0.1	0.2	-0.5	0.2	0.2
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.5	0.2	0.3
Condit. Reinf. lever presses	0.1	0.1	0.1	-0.3	0.3	0.2
Condit. Reinf. lever reinforcers received	0.2	0.2	0.4	-0.6	0.4	0.4
Conditioned reinforcement - actives	0.2	0.4	0.5	0.6	-0.7	-0.6
Conditioned reinforcement - inactives	0.4	0.6	1.0	0.4	-1.0	-0.8
Conditioned locomotion	0.0	0.0	0.0	-0.2	0.0	0.0
Patch foraging indifference point 0 sec	0.8	1.5	1.7	-1.2	1.2	1.3
Patch foraging indifference point AUC	0.2	0.3	0.3	-0.6	0.5	0.6
Delay disc. indifference point, 0s delay	1.2	1.3	1.7	-1.3	1.0	1.1
Delay disc. indifference point, 16s delay	2.1	2.4	2.7	-1.4	1.7	1.5
Delay disc. indifference point, 2s delay	0.5	0.5	0.8	-0.9	0.5	0.8
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	-0.3	0.5	0.6
Delay disc. indifference point, 4s delay	0.8	0.8	1.2	-1.1	0.8	0.8
Delay disc. indifference point, 8s delay	0.8	0.9	1.0	-0.9	1.0	1.0
Indifference point function ln k	0.4	0.8	1.0	-0.7	1.0	0.9
Indifference point function log k	0.4	0.8	1.0	-0.7	1.0	0.9
Patch foraging total patch changes 0 sec	0.5	1.0	1.1	-1.0	1.0	1.1
Patch foraging total patch changes 12 sec	2.4	3.2	3.9	-2.0	1.6	1.8
Patch foraging total patch changes 18 sec	0.2	0.3	0.3	-0.5	0.5	0.6
Patch foraging total patch changes 24 sec	1.9	3.2	3.5	-1.8	1.9	1.7
Patch foraging total patch changes 6 sec	1.0	1.5	1.7	-1.2	1.1	1.3
Patch foraging time to switch 0 sec	0.0	0.0	0.0	-0.0	-0.0	-0.0
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.2	0.0	0.0
Patch foraging water rate 12 sec	0.3	0.5	0.6	0.8	-0.6	-0.8
Patch foraging water rate 18 sec	1.4	2.1	2.3	-1.4	1.5	1.5
Patch foraging water rate 24 sec	0.1	0.1	0.1	-0.3	0.3	0.3
Patch foraging water rate 6 sec	1.1	1.6	1.9	-1.4	1.2	1.2
Seeking ratio, delayed vs. immediate footshock	1.0	1.3	1.8	1.0	-1.0	-1.3
Distance traveled before self-admin	1.2	1.6	1.9	1.0	-1.4	-1.4
Distance traveled after self-admin	0.5	0.6	0.8	0.6	-0.8	-0.9
Extensor digitorum longus weight	9.2	36.2	39.5	6.3	-5.7	-6.0
Bone: elastic displacement	0.0	0.1	0.1	-0.2	0.2	0.3
Bone: elastic work	0.1	0.2	0.2	-0.4	0.3	0.5
Bone: endosteal estimation	2.5	5.5	6.1	2.5	-2.4	-2.2
Bone: endosteal perimeter	2.2	4.7	4.9	2.2	-2.2	-2.1
Epididymis fat weight	0.4	1.3	1.7	0.9	-1.3	-1.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	0.8	-0.4	-0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.2	-0.4	-0.5
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	-0.1	-0.1
Delay discount exponential model param	1.2	1.4	1.5	1.1	-1.2	-1.2
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.0	-0.0	0.1
Active lever presses in extinction session 6	1.2	1.2	1.4	-1.2	0.8	1.2
Bone: final force	0.7	1.1	1.3	-1.1	1.0	1.1
Bone: final moment	0.6	1.0	1.2	-1.0	0.9	1.1
Food consumed during 24 hour testing period	1.1	1.5	1.6	1.2	-1.3	-1.2
Glucose	0.1	0.2	0.5	-0.7	-0.0	0.1
Heart weight	3.2	4.9	5.1	2.2	-2.2	-2.2
Delay discount hyperbolic model param	0.8	0.9	1.0	0.9	-0.9	-1.0
Intermittent access intake day 1-15 change	0.0	0.0	0.1	-0.2	0.2	0.2
Intermittent access intake escalation	0.0	0.0	0.0	-0.2	0.0	0.1
Intermittent access intake escalation 2	0.1	0.2	0.2	0.3	-0.5	-0.4
Intermitt. access day 1 inactive lever presses	0.7	2.6	3.2	-1.8	1.5	1.5
Intermitt. access day 15 inactive lever presses	1.0	2.1	2.3	-1.5	1.4	1.3
Intermitt. access escalation Index	0.1	0.2	0.4	-0.1	0.6	0.4
Intermittent access day 1 total infusions	0.6	1.0	1.2	0.8	-1.1	-1.0
Intermittent access day 15 total infusions	0.1	0.2	0.2	0.2	-0.5	-0.4
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.0	-0.3	-0.1
Intermittent access total infusions	0.5	0.6	0.8	0.6	-0.9	-0.8
Intermittent access day 1 locomotion	0.5	0.7	0.8	0.7	-0.9	-0.8
Intermittent access day 15 total locomotion	0.1	0.2	0.4	0.3	-0.6	-0.4
Intermittent access total locomotion	0.0	0.0	0.1	-0.2	0.1	0.2
Intermittent access standard deviation	0.1	0.2	0.4	-0.6	0.1	0.3
Left kidney weight	0.1	0.4	0.5	0.7	-0.5	-0.7
Right kidney weight	0.0	0.1	0.1	-0.4	0.2	0.3
Cocaine induced anxiety	0.2	0.2	0.5	0.7	-0.3	-0.2
Post-drug Anxiety	0.1	0.1	0.2	0.1	0.3	0.4
Baseline Anxiety	0.2	0.2	0.3	-0.6	0.4	0.4
Tail length	0.7	2.8	3.3	1.8	-1.7	-1.5
Length with tail	2.7	11.7	12.8	3.6	-3.4	-3.3
Length without tail	2.7	8.7	9.0	3.0	-2.9	-2.9
Times rat made contact with spout	0.8	0.9	1.0	-1.0	0.9	1.0
Lifetime Intake	0.2	0.3	0.5	0.4	-0.7	-0.6
Liver weight, left	0.1	0.2	0.2	0.5	-0.5	-0.3
Liver weight, right	2.6	4.6	5.0	-2.1	2.1	2.2
Locomotor activity	0.1	0.1	0.3	-0.6	0.1	0.3
Locomotor testing distance	1.4	2.5	3.1	-1.8	1.5	1.5
Locomotor testing rearing	4.6	9.3	10.0	-3.2	2.9	3.1
Locomotion in novel chamber	1.5	1.9	2.4	-1.5	1.3	1.3
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.2	0.0	0.1
Fecal boli incidents, locomotor time 1	0.6	0.9	1.1	0.9	-1.1	-0.9
Change in fecal boli incidents, locomotor task	0.2	0.2	0.2	-0.5	0.4	0.4
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.0	-0.6	1.0	0.9
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.0	0.4	0.4
Total resting periods, locomotor time 1	0.1	0.1	0.3	0.5	-0.2	-0.2
Rest time, locomotor task time 1	0.0	0.0	0.0	0.1	-0.0	0.0
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.0	-0.1	-0.1
Vertical activity count, locomotor time 1	0.5	1.1	1.2	1.0	-1.1	-1.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	-0.1	-0.0	-0.0
Bouts of movement, locomotor time 2	0.9	1.5	2.0	-1.0	1.4	1.2
Total resting periods, locomotor time 2	0.8	1.3	1.9	-0.9	1.4	1.2
Rest time, locomotor task time 2	0.3	0.3	0.6	0.8	-0.5	-0.4
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.2	0.1	0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.1	0.4	-0.3	-0.3
Light reinforcement 1	1.3	3.3	4.0	-2.0	1.7	1.7
Light reinforcement 2	0.2	0.4	0.7	-0.8	0.3	0.6
Bone: marrow area	2.4	5.3	5.8	2.4	-2.3	-2.2
Bone: maximum diameter	0.0	0.1	0.1	0.3	-0.3	-0.3
Bone: maximum force	0.0	0.0	0.0	0.1	-0.0	0.1
Bone: maximum moment	0.0	0.0	0.0	0.1	-0.0	0.1
Mean time between licks in bursts	0.8	2.0	2.0	1.4	-1.4	-1.4
Mean num. licks in bursts	0.3	0.5	0.5	-0.6	0.7	0.7
Cd content in liver	0.9	1.0	1.2	1.1	-1.0	-0.9
Co content in liver	1.6	1.8	2.0	1.4	-1.3	-1.3
Cu content in liver	0.1	0.1	0.1	-0.2	0.3	0.3
Fe content in liver	2.7	3.3	3.6	1.8	-1.9	-1.7
K content in liver	0.9	0.9	0.9	-1.0	0.9	0.9
Mg content in liver	1.7	1.8	2.0	-1.3	1.4	1.3
Mn content in liver	0.8	0.9	0.9	-1.0	1.0	1.0
Na content in liver	0.0	0.0	0.1	-0.3	0.0	0.2
Rb content in liver	2.0	2.4	2.5	-1.6	1.4	1.6
Se content in liver	5.1	6.0	6.7	-2.6	2.3	2.4
Sr content in liver	0.2	0.2	0.3	0.5	-0.4	-0.5
Zn content in liver	2.7	3.0	3.3	-1.8	1.7	1.7
Bone: minimum diameter	0.4	0.7	0.8	0.9	-0.8	-0.7
Time in familiar zone, hab. session 1	0.8	0.8	1.0	0.8	-1.0	-0.9
Time in novel zone, hab. session 1	4.0	4.0	4.5	-1.8	2.1	2.1
Total zone transitions, hab. session 1	3.0	4.2	4.3	2.1	-2.1	-2.0
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.2	-0.1	-0.1
Locomotion velocity, hab. session 1	0.5	0.7	0.7	0.7	-0.8	-0.9
Time in familiar zone, hab. session 2	0.2	0.2	0.2	-0.5	0.3	0.5
Time in novel zone, hab. session 2	0.4	0.4	0.5	-0.6	0.7	0.6
Total zone transitions, hab. session 2	1.0	1.2	1.4	1.1	-1.2	-1.0
Total locomotion distance, hab. session 2	0.2	0.2	0.3	0.5	-0.6	-0.4
Locomotion velocity, hab. session 2	0.6	0.8	0.9	0.8	-1.0	-0.8
Novel to familiar place preference ratio	0.8	0.9	1.3	1.1	-0.7	-0.9
Novelty place preference	0.6	0.6	0.9	1.0	-0.5	-0.8
Time in novel zone, NPP test	0.1	0.1	0.2	0.4	-0.0	-0.3
Total zone transitions, NPP test	2.0	2.9	3.8	1.5	-1.9	-1.6
Total locomotion distance, NPP test	0.1	0.2	0.3	0.3	-0.6	-0.3
Locomotion velocity, NPP test	0.9	1.2	1.7	1.0	-1.3	-1.0
Intraocular pressure	3.6	5.2	6.0	2.4	-2.2	-2.1
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.0	0.4	0.3
Delta ambulatory time before/after self-admin	0.8	1.0	1.4	-0.7	1.1	1.2
Parametrial fat weight	0.1	0.1	0.2	-0.5	0.2	0.3
Pavlov. Cond. lever latency	2.2	2.8	2.9	1.7	-1.6	-1.7
Pavlov. Cond. magazine entry latency	7.4	9.5	10.9	-3.3	3.0	3.0
Pavlov. Cond. change in total contacts	10.7	11.3	11.7	-3.4	3.4	3.3
Pavlov. Cond. index score	7.2	9.0	10.0	-3.2	2.9	3.0
Pavlov. Cond. latency score	5.9	7.4	8.0	-2.8	2.6	2.7
Pavlov. Cond. lever contacts	2.0	2.4	2.6	-1.6	1.5	1.5
Pavlov. Cond. magazine entry number	13.6	17.2	18.5	4.3	-4.1	-4.1
Pavlov. Cond. intertrial magazine entries	1.2	1.4	1.7	1.3	-1.1	-1.2
Pavlov. Cond. lever-magazine prob. diff.	8.1	10.0	11.2	-3.4	3.0	3.1
Pavlov. Cond. response bias	9.7	12.0	13.3	-3.6	3.4	3.4
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.5	-0.3	-0.2
Pavlov. Cond. magazine entry latency	1.4	1.6	1.9	1.0	-1.4	-1.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.0	-0.2	-0.3
Pavlov. Cond. index score	0.1	0.2	0.3	0.2	-0.5	-0.5
Pavlov. Cond. latency score	0.2	0.3	0.4	0.3	-0.6	-0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.5	0.3	0.3
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	-0.3	0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.0	1.0	-0.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.4	0.4	-0.7	-0.7
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.6	0.2	0.2
Time in closed arm before self-admin	2.3	3.0	3.3	-1.7	1.6	1.8
Time in closed arm after self-admin	0.5	0.5	0.6	-0.6	0.8	0.8
Time in open arm before self-admin	2.0	2.2	2.7	1.6	-1.3	-1.5
Time in open arm after self-admin	1.4	1.5	1.7	1.2	-1.2	-1.3
Bone: periosteal estimation	0.3	0.7	0.8	0.9	-0.8	-0.7
Bone: periosteal perimeter	1.5	2.5	2.7	1.5	-1.6	-1.6
Bone: post-yield work	0.6	0.9	1.2	1.1	-0.9	-0.9
Progressive ratio test 1 active lever presses	0.1	0.2	0.3	-0.3	0.3	0.5
Progressive ratio test 1 breakpoint	0.1	0.2	0.3	-0.3	0.4	0.5
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.3	-0.5	0.5	0.6
Progressive ratio test 2 active lever presses	0.6	0.7	1.0	0.5	-1.0	-0.9
Progressive ratio test 2 breakpoint	0.6	0.7	1.0	0.5	-1.0	-0.9
Progressive ratio test 2 inactive lever presses	0.7	1.1	1.5	0.8	-1.2	-1.1
Incentive Sensitization - Responses	1.8	2.6	3.5	1.1	-1.9	-1.8
Incentive Sensitization - Breakpoint	2.0	2.6	3.5	1.1	-1.9	-1.8
Sum of active levers in priming session hrs 5-6	1.7	1.6	1.8	-1.3	1.2	1.3
Progressive ratio	0.0	0.1	0.1	0.3	-0.2	-0.2
Food seeking constrained by brief footshock	1.5	1.8	2.0	-1.4	1.3	1.3
Seeking ratio, punishment vs. effort	0.6	0.9	1.0	-1.0	0.9	0.9
Retroperitoneal fat weight	0.1	0.3	0.3	-0.6	0.4	0.5
Reaction time number correct	1.8	3.5	3.9	1.8	-1.9	-2.0
Reaction time mean minus median	0.0	0.1	0.1	0.3	-0.3	-0.4
Reaction time mean minus median AUC	0.1	0.1	0.2	-0.4	0.4	0.3
Reaction time num false alarms	0.0	0.0	0.1	0.1	-0.3	-0.1
Reaction time num false alarms AUC	0.1	0.2	0.4	0.3	-0.6	-0.5
Reaction time trials correct on left	1.8	3.5	3.9	1.8	-1.9	-2.0
Reaction time trials on left	1.8	3.4	3.8	1.7	-1.9	-2.0
Reaction time mean	0.3	0.5	0.6	-0.8	0.7	0.6
Reaction time mean AUC	0.5	0.8	0.9	-0.9	0.9	0.8
Median of all reaction times	0.8	1.2	1.5	-1.2	1.1	1.0
Reaction time omissions	0.3	0.4	0.6	-0.8	0.5	0.5
Reaction time false alarm rate	0.3	0.3	0.4	-0.6	0.5	0.6
Reaction time premature initiation rate	1.3	1.8	1.9	-1.4	1.3	1.3
Reaction time premature initiations	0.0	0.0	0.1	-0.2	0.1	0.1
Std. dev. reaction times	0.0	0.1	0.1	-0.3	0.2	0.2
Reaction time trials completed	1.8	3.4	3.8	1.7	-1.9	-2.0
Reaction time trials AUC	1.7	3.3	3.8	1.7	-1.8	-1.9
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.3	-0.2	-0.3
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.2	-0.0	-0.1
Latency to leave start box in cocaine runway	4.3	4.9	5.8	2.1	-2.2	-2.4
Latency to leave start box in cocaine runway, F	5.6	6.4	7.5	2.3	-2.5	-2.7
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.0	0.0	0.0
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.0	-0.0	-0.0
Total sessions with >9 infusions	0.0	0.0	0.1	-0.2	0.2	0.2
Short access day 1 total inactive lever presses	0.3	0.4	0.8	-0.9	0.3	0.5
Short access day 10 total inactive lever presses	0.1	0.2	0.3	0.3	-0.4	-0.5
Short access day 1 total infusions	0.6	0.9	0.9	-1.0	0.9	0.9
Short access day 10 total infusions	0.0	0.0	0.1	-0.2	-0.2	-0.0
Short access total infusions	0.0	0.0	0.0	-0.2	-0.0	0.0
Short access day 1 locomotion	1.4	1.8	1.9	-1.4	1.3	1.3
Short access day 10 total locomotion	0.2	0.4	0.7	-0.8	0.5	0.7
Short access total locomotion	0.0	0.0	0.1	-0.1	-0.2	-0.1
One hour access (0.3 mA shock)	0.5	0.6	0.8	0.9	-0.7	-0.7
Compulsive drug intake	1.7	2.0	3.2	-0.8	1.8	1.5
One hour access (shock baseline)	0.5	0.8	1.1	0.7	-1.1	-1.0
Social response proportion	0.1	0.2	0.2	-0.3	0.4	0.5
Social responses	0.2	0.2	0.4	-0.4	0.3	0.6
Social time	0.2	0.3	0.5	0.3	-0.7	-0.4
Soleus weight	0.0	0.0	0.0	-0.1	0.0	0.1
Bone: stiffness	0.0	0.1	0.1	0.2	-0.3	-0.2
Tibialis anterior weight	1.5	5.0	5.6	2.4	-2.2	-2.2
Time to tail flick, vehicle, before self-admin	0.4	0.5	0.8	0.5	-0.9	-0.6
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.1	0.1	0.1
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.1	0.1	0.2
Time to tail flick, test, after self-admin	0.2	0.2	0.5	0.3	-0.7	-0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.2	-0.4	0.5	0.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.2	-0.3	-0.1
Tibia length	0.8	2.1	2.4	1.6	-1.5	-1.3
Ambulatory time before self-admin	1.4	2.0	2.5	1.1	-1.6	-1.6
Ambulatory time after self-admin	0.4	0.4	0.5	0.6	-0.7	-0.7
Bone: tissue strength	0.4	0.4	0.5	0.7	-0.5	-0.6
Total heroin consumption	0.1	0.1	0.2	-0.4	-0.2	0.0
Bone: trabecular number	6.0	10.0	10.8	-3.3	3.0	3.2
Bone: trabecular spacing	2.7	3.6	3.7	1.9	-1.9	-1.9
Bone: trabecular thickness	0.1	0.2	0.2	-0.4	0.4	0.4
Bone: trabecular tissue density	0.3	0.5	0.7	-0.5	0.9	0.7
Water consumed over 24 hours	0.2	0.3	0.4	0.5	-0.6	-0.5
Number of responses in last shaping day	0.5	0.6	0.7	-0.6	0.8	0.8