Hub : Genes

Med24

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA isoform ratio XM_006247416.4 0.71 0.11 4.8e-04 -0 0.02 0.06 0.03 5.0e-01 2.9e-02 6.1e-04 7.5e-03
2 BLA alternative TSS XM_039086760.1 0.62 0.15 2.5e-03 0.02 0.02 0.05 0.04 2.3e-02 2.4e-02 8.6e-04 3.8e-03
3 BLA alternative TSS XM_039086760.1 0.58 0.14 1.1e-03 0.03 0.04 0.06 0.05 1.0e-02 4.0e-03 5.4e-04 1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density3.25.86.32.5-2.3-2.4
Area under the delay curve1.01.61.71.2-1.2-1.3
BMI with tail0.51.62.1-1.41.31.1
BMI without tail0.20.91.4-1.21.00.6
Body weight3.615.818.0-4.24.03.7
Weight adjusted by age0.00.10.2-0.40.40.3
Bone surface0.00.00.10.2-0.0-0.3
Bone volume0.10.20.30.5-0.3-0.5
Breakpoint value in progressive ratio session0.50.91.0-0.91.00.9
Number of licking bursts0.00.00.00.20.0-0.0
Context. condit. distance diff. score0.20.30.4-0.60.40.5
Locomotion velocity, session 12.22.52.9-1.41.71.7
Locomotion distance, session 13.34.24.7-2.12.21.9
Locomotion velocity, session 20.40.40.5-0.60.70.7
Locomotion distance, session 20.20.30.5-0.60.70.4
Locomotion velocity, session 30.50.60.80.6-0.9-0.8
Locomotion distance, session 30.00.10.1-0.30.20.1
Stereotopy head waving bouts, day 33.33.94.12.0-2.0-2.0
Stereotopy head waving duration, day 30.30.40.40.7-0.6-0.6
Locomotion velocity, session 71.31.51.9-1.41.11.1
Locomotion distance, session 71.31.61.8-1.31.21.2
Stereotopy head waving bouts, day 74.04.65.02.0-2.2-2.2
Stereotopy head waving duration, day 72.83.43.91.6-2.0-1.9
Locomotion velocity, session 87.89.49.7-3.13.03.1
Locomotion distance, session 81.11.71.8-1.41.31.2
Degree of sensitization distance2.22.32.4-1.51.51.6
Degree of sensitization stereotypy4.55.05.42.0-2.3-2.3
Conditioned locomotion0.50.60.70.7-0.8-0.7
Cocaine response after cond. corrected1.01.51.81.2-1.1-1.3
Cocaine response after cond. not corrected0.60.81.01.0-0.7-1.0
Cocaine response before conditioning0.10.10.2-0.20.40.4
Saline control response0.20.30.3-0.60.60.6
Bone: connectivity density4.36.97.32.7-2.5-2.6
Bone: cortical apparent density3.75.96.82.6-2.4-2.3
Bone: cortical area0.20.30.30.5-0.5-0.5
Bone: cortical porosity0.20.20.30.6-0.4-0.4
Bone: cortical porosity0.00.00.00.2-0.1-0.1
Bone: cortical thickness2.13.53.71.9-1.9-1.8
Bone: cortical thickness4.25.15.52.4-2.3-2.1
Bone: cortical tissue density3.55.66.52.6-2.3-2.2
Condit. Reinf. active minus inactive responses1.21.41.51.2-1.2-1.1
Condit. Reinf. active-inactive response ratio2.42.63.01.5-1.7-1.6
Condit. Reinf. active responses0.50.60.70.8-0.8-0.7
Condit. Reinf. inactive responses0.10.10.1-0.10.30.3
Incentive salience index mean1.11.41.61.3-1.2-1.1
Condit. Reinf. lever presses0.30.40.60.8-0.6-0.5
Condit. Reinf. active minus inactive responses0.00.10.10.3-0.2-0.2
Condit. Reinf. active-inactive response ratio0.20.30.40.6-0.5-0.6
Condit. Reinf. active responses0.10.10.20.4-0.2-0.2
Condit. Reinf. inactive responses0.10.10.20.5-0.2-0.3
Condit. Reinf. lever presses0.10.10.10.3-0.3-0.2
Condit. Reinf. lever reinforcers received0.20.20.40.6-0.4-0.4
Conditioned reinforcement - actives0.10.40.5-0.60.70.6
Conditioned reinforcement - inactives0.20.61.0-0.51.00.8
Conditioned locomotion0.00.00.00.1-0.0-0.0
Patch foraging indifference point 0 sec0.51.51.71.2-1.2-1.3
Patch foraging indifference point AUC0.10.30.40.6-0.5-0.6
Delay disc. indifference point, 0s delay1.11.31.71.3-1.0-1.1
Delay disc. indifference point, 16s delay1.72.42.71.4-1.7-1.5
Delay disc. indifference point, 2s delay0.50.50.70.8-0.5-0.8
Delay disc. indifference point, 24s delay0.10.20.30.3-0.5-0.6
Delay disc. indifference point, 4s delay0.80.81.11.1-0.8-0.8
Delay disc. indifference point, 8s delay0.50.91.00.9-1.0-1.0
Indifference point function ln k0.30.81.00.7-1.0-0.9
Indifference point function log k0.30.81.00.7-1.0-0.9
Patch foraging total patch changes 0 sec0.31.01.11.0-1.0-1.1
Patch foraging total patch changes 12 sec2.33.13.81.9-1.6-1.8
Patch foraging total patch changes 18 sec0.10.30.30.5-0.5-0.6
Patch foraging total patch changes 24 sec1.03.33.51.8-1.9-1.7
Patch foraging total patch changes 6 sec0.91.51.71.2-1.1-1.3
Patch foraging time to switch 0 sec0.00.00.0-0.00.00.0
Patch foraging water rate 0 sec0.00.00.00.2-0.0-0.0
Patch foraging water rate 12 sec0.10.50.6-0.80.60.8
Patch foraging water rate 18 sec1.02.12.31.4-1.5-1.5
Patch foraging water rate 24 sec0.10.10.10.3-0.3-0.3
Patch foraging water rate 6 sec1.11.61.91.4-1.2-1.2
Seeking ratio, delayed vs. immediate footshock0.91.31.8-1.01.01.3
Distance traveled before self-admin0.71.61.9-0.91.41.4
Distance traveled after self-admin0.40.60.8-0.60.80.9
Extensor digitorum longus weight9.036.038.8-6.25.76.0
Bone: elastic displacement0.00.00.10.2-0.2-0.3
Bone: elastic work0.10.20.20.4-0.3-0.5
Bone: endosteal estimation2.35.56.0-2.52.42.2
Bone: endosteal perimeter1.94.84.9-2.22.22.1
Epididymis fat weight0.31.31.7-0.81.31.2
Delta time in closed arm before/after self-admin0.30.30.5-0.70.40.5
Delta time in open arm before/after self-admin0.10.10.2-0.20.40.5
Diff in mean of infusions in LGA sessions0.00.00.0-0.10.10.1
Delay discount exponential model param1.01.31.5-1.11.21.2
Extinction: sum of active levers before priming0.00.00.0-0.00.0-0.1
Active lever presses in extinction session 61.21.21.51.2-0.8-1.2
Bone: final force0.71.11.31.1-1.0-1.1
Bone: final moment0.61.01.21.0-0.9-1.1
Food consumed during 24 hour testing period0.81.51.6-1.21.31.2
Glucose0.10.20.50.70.0-0.1
Heart weight3.04.95.0-2.22.22.2
Delay discount hyperbolic model param0.70.91.0-0.90.91.0
Intermittent access intake day 1-15 change0.00.00.10.2-0.2-0.2
Intermittent access intake escalation0.00.00.00.1-0.0-0.1
Intermittent access intake escalation 20.10.20.2-0.40.50.4
Intermitt. access day 1 inactive lever presses0.22.63.31.8-1.5-1.5
Intermitt. access day 15 inactive lever presses0.42.12.31.5-1.4-1.3
Intermitt. access escalation Index0.10.20.40.1-0.6-0.4
Intermittent access day 1 total infusions0.31.01.2-0.81.11.0
Intermittent access day 15 total infusions0.10.20.2-0.30.50.4
Intermittent access terminal intake (last 3 days)0.00.00.10.00.30.1
Intermittent access total infusions0.50.60.8-0.60.90.8
Intermittent access day 1 locomotion0.40.70.8-0.80.90.8
Intermittent access day 15 total locomotion0.10.20.4-0.40.60.4
Intermittent access total locomotion0.00.00.00.2-0.1-0.2
Intermittent access standard deviation0.00.10.30.6-0.1-0.3
Left kidney weight0.00.40.5-0.60.50.7
Right kidney weight0.00.10.20.4-0.2-0.3
Cocaine induced anxiety0.10.20.5-0.70.30.2
Post-drug Anxiety0.10.10.2-0.1-0.3-0.4
Baseline Anxiety0.10.20.30.5-0.4-0.4
Tail length0.52.83.3-1.81.71.5
Length with tail2.611.612.6-3.53.43.3
Length without tail1.68.78.8-3.02.92.9
Times rat made contact with spout0.80.91.01.0-0.9-1.0
Lifetime Intake0.20.30.5-0.40.70.6
Liver weight, left0.10.20.2-0.50.50.3
Liver weight, right2.64.65.02.1-2.1-2.2
Locomotor activity0.10.10.30.6-0.1-0.3
Locomotor testing distance1.02.53.01.7-1.5-1.5
Locomotor testing rearing2.59.29.73.1-2.9-3.1
Locomotion in novel chamber1.41.92.41.5-1.3-1.3
Locomotion in novel chamber post-restriction0.00.00.00.2-0.0-0.1
Fecal boli incidents, locomotor time 10.40.91.1-0.91.10.9
Change in fecal boli incidents, locomotor task0.10.20.20.5-0.4-0.4
Time >=10cm from walls, locomotor time 10.60.71.00.6-1.0-0.9
Bouts of movement, locomotor time 10.10.10.20.0-0.4-0.4
Total resting periods, locomotor time 10.10.10.3-0.50.20.2
Rest time, locomotor task time 10.00.00.0-0.10.0-0.0
Distance moved, locomotor task time 10.00.00.00.00.10.1
Vertical activity count, locomotor time 10.21.11.2-1.01.11.1
Time >=10cm from walls, locomotor time 20.00.00.00.10.00.0
Bouts of movement, locomotor time 20.51.52.01.0-1.4-1.2
Total resting periods, locomotor time 20.31.41.90.9-1.4-1.2
Rest time, locomotor task time 20.20.30.6-0.80.50.4
Distance moved, locomotor task time 20.00.00.10.3-0.1-0.2
Vertical activity count, locomotor time 20.00.10.1-0.40.30.3
Light reinforcement 10.73.34.02.0-1.7-1.7
Light reinforcement 20.20.40.70.8-0.3-0.6
Bone: marrow area2.25.35.8-2.42.32.2
Bone: maximum diameter0.00.10.1-0.20.30.3
Bone: maximum force0.00.00.0-0.00.0-0.1
Bone: maximum moment0.00.00.0-0.10.0-0.1
Mean time between licks in bursts0.32.02.0-1.41.41.4
Mean num. licks in bursts0.20.50.50.6-0.7-0.7
Cd content in liver0.91.01.2-1.11.00.9
Co content in liver1.51.82.0-1.41.31.3
Cu content in liver0.10.10.10.2-0.3-0.3
Fe content in liver2.73.33.6-1.81.91.7
K content in liver0.90.91.01.0-0.9-0.9
Mg content in liver1.61.82.01.3-1.4-1.3
Mn content in liver0.80.91.01.0-1.0-1.0
Na content in liver0.00.10.10.3-0.0-0.2
Rb content in liver2.02.32.51.5-1.4-1.6
Se content in liver5.06.06.72.6-2.3-2.4
Sr content in liver0.20.20.3-0.50.40.5
Zn content in liver2.63.03.31.8-1.7-1.7
Bone: minimum diameter0.40.70.8-0.90.80.7
Time in familiar zone, hab. session 10.70.81.0-0.81.00.9
Time in novel zone, hab. session 13.64.04.51.8-2.1-2.1
Total zone transitions, hab. session 13.04.24.4-2.12.12.0
Total locomotion distance, hab. session 10.00.00.0-0.20.10.1
Locomotion velocity, hab. session 10.50.70.7-0.70.80.9
Time in familiar zone, hab. session 20.10.20.20.5-0.3-0.5
Time in novel zone, hab. session 20.40.40.50.6-0.7-0.6
Total zone transitions, hab. session 21.01.21.4-1.11.21.0
Total locomotion distance, hab. session 20.20.20.3-0.50.60.4
Locomotion velocity, hab. session 20.60.80.9-0.91.00.8
Novel to familiar place preference ratio0.70.91.3-1.10.70.9
Novelty place preference0.50.60.9-1.00.50.8
Time in novel zone, NPP test0.10.10.2-0.40.00.3
Total zone transitions, NPP test2.02.93.8-1.51.91.6
Total locomotion distance, NPP test0.10.20.3-0.30.60.3
Locomotion velocity, NPP test0.91.31.7-1.01.31.0
Intraocular pressure3.25.26.1-2.52.22.1
Delta distance traveled before/after self-admin0.10.10.20.1-0.4-0.3
Delta ambulatory time before/after self-admin0.61.01.40.7-1.1-1.2
Parametrial fat weight0.10.10.20.5-0.2-0.3
Pavlov. Cond. lever latency2.22.82.9-1.71.61.7
Pavlov. Cond. magazine entry latency7.49.510.83.3-3.0-3.0
Pavlov. Cond. change in total contacts10.511.411.73.4-3.4-3.3
Pavlov. Cond. index score7.19.09.93.2-2.9-3.0
Pavlov. Cond. latency score5.87.48.02.8-2.6-2.7
Pavlov. Cond. lever contacts2.02.42.61.6-1.5-1.5
Pavlov. Cond. magazine entry number13.517.218.4-4.34.14.1
Pavlov. Cond. intertrial magazine entries1.21.41.7-1.31.11.2
Pavlov. Cond. lever-magazine prob. diff.8.09.911.13.3-3.0-3.1
Pavlov. Cond. response bias9.612.013.33.6-3.4-3.4
Pavlov. Cond. lever latency0.10.10.2-0.40.30.2
Pavlov. Cond. magazine entry latency1.21.61.9-1.01.41.4
Pavlov. Cond. change in total contacts0.00.00.10.00.20.3
Pavlov. Cond. index score0.10.20.3-0.20.50.5
Pavlov. Cond. latency score0.20.30.4-0.40.60.6
Pavlov. Cond. lever contacts0.10.10.30.5-0.3-0.3
Pavlov. Cond. magazine entry number0.20.30.40.3-0.6-0.6
Pavlov. Cond. intertrial magazine entries0.30.61.0-1.00.60.7
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.40.70.7
Pavlov. Cond. response bias0.10.10.30.6-0.2-0.2
Time in closed arm before self-admin1.73.03.31.7-1.6-1.8
Time in closed arm after self-admin0.50.50.60.6-0.8-0.8
Time in open arm before self-admin1.82.22.6-1.61.31.5
Time in open arm after self-admin1.41.51.7-1.21.21.3
Bone: periosteal estimation0.30.70.7-0.90.80.7
Bone: periosteal perimeter1.32.52.7-1.51.61.6
Bone: post-yield work0.50.91.1-1.10.90.9
Progressive ratio test 1 active lever presses0.10.20.30.3-0.3-0.5
Progressive ratio test 1 breakpoint0.10.20.30.3-0.4-0.5
Progressive ratio test 1 inactive lever presses0.10.30.30.6-0.5-0.6
Progressive ratio test 2 active lever presses0.50.71.0-0.61.00.9
Progressive ratio test 2 breakpoint0.50.71.0-0.51.00.9
Progressive ratio test 2 inactive lever presses0.31.11.5-0.81.21.1
Incentive Sensitization - Responses1.02.63.5-1.11.91.8
Incentive Sensitization - Breakpoint1.22.63.5-1.11.91.8
Sum of active levers in priming session hrs 5-61.81.71.81.3-1.2-1.3
Progressive ratio0.00.00.1-0.30.20.2
Food seeking constrained by brief footshock1.51.82.11.4-1.3-1.3
Seeking ratio, punishment vs. effort0.40.91.01.0-0.9-0.9
Retroperitoneal fat weight0.10.30.30.6-0.4-0.5
Reaction time number correct1.03.53.9-1.81.92.0
Reaction time mean minus median0.00.10.1-0.30.30.4
Reaction time mean minus median AUC0.00.10.20.4-0.4-0.3
Reaction time num false alarms0.00.10.1-0.10.30.1
Reaction time num false alarms AUC0.10.20.4-0.40.60.5
Reaction time trials correct on left1.03.53.9-1.81.92.0
Reaction time trials on left1.03.43.8-1.71.92.0
Reaction time mean0.20.50.60.8-0.7-0.6
Reaction time mean AUC0.30.80.90.9-0.9-0.8
Median of all reaction times0.81.21.41.2-1.1-1.0
Reaction time omissions0.20.40.60.8-0.5-0.5
Reaction time false alarm rate0.20.30.40.6-0.5-0.6
Reaction time premature initiation rate1.21.82.01.4-1.3-1.3
Reaction time premature initiations0.00.00.10.2-0.1-0.1
Std. dev. reaction times0.00.10.10.3-0.2-0.2
Reaction time trials completed1.03.43.8-1.71.92.0
Reaction time trials AUC1.03.33.8-1.71.81.9
Run reversals in cocaine runway, females0.10.10.1-0.30.20.3
Run reversals in cocaine runway, males0.00.00.00.20.00.1
Latency to leave start box in cocaine runway3.64.95.8-2.12.22.4
Latency to leave start box in cocaine runway, F5.16.37.5-2.32.52.7
Latency to leave start box in cocaine runway, M0.00.00.00.0-0.0-0.0
Std. dev. time between licks in bursts0.00.00.00.00.00.0
Total sessions with >9 infusions0.00.00.10.3-0.2-0.2
Short access day 1 total inactive lever presses0.20.40.70.8-0.3-0.5
Short access day 10 total inactive lever presses0.00.20.3-0.30.40.5
Short access day 1 total infusions0.40.91.01.0-0.9-0.9
Short access day 10 total infusions0.00.00.00.20.20.0
Short access total infusions0.00.00.00.20.0-0.0
Short access day 1 locomotion1.11.82.01.4-1.3-1.3
Short access day 10 total locomotion0.10.40.60.8-0.5-0.7
Short access total locomotion0.00.00.10.00.20.1
One hour access (0.3 mA shock)0.50.60.8-0.90.70.7
Compulsive drug intake1.42.03.20.9-1.8-1.5
One hour access (shock baseline)0.30.81.1-0.71.11.0
Social response proportion0.10.20.20.3-0.4-0.5
Social responses0.20.20.40.4-0.3-0.6
Social time0.20.30.5-0.20.70.4
Soleus weight0.00.00.00.1-0.0-0.1
Bone: stiffness0.00.10.1-0.20.30.2
Tibialis anterior weight1.55.05.5-2.32.22.2
Time to tail flick, vehicle, before self-admin0.40.50.8-0.50.90.6
Time to tail flick, vehicle, after self-admin0.00.00.0-0.1-0.1-0.1
Time to tail flick, test, before self-admin0.00.00.0-0.1-0.1-0.2
Time to tail flick, test, after self-admin0.20.20.5-0.30.70.3
Delta time to tail flick, vehicle, before/after SA0.20.20.20.4-0.5-0.4
Delta time to tail flick, test, before/after SA0.00.00.10.20.30.1
Tibia length0.82.12.4-1.61.51.3
Ambulatory time before self-admin0.72.02.5-1.11.61.6
Ambulatory time after self-admin0.30.40.5-0.50.70.7
Bone: tissue strength0.30.40.5-0.70.50.6
Total heroin consumption0.10.10.20.40.2-0.0
Bone: trabecular number5.310.010.93.3-3.0-3.2
Bone: trabecular spacing2.53.63.8-1.91.91.9
Bone: trabecular thickness0.10.20.20.4-0.4-0.4
Bone: trabecular tissue density0.30.50.70.5-0.9-0.7
Water consumed over 24 hours0.20.30.4-0.50.60.5
Number of responses in last shaping day0.40.60.70.6-0.8-0.8