Med1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Med1	0.04	0.03	6.5e-05	0.02	0.03	0.03	0.03	1.3e-03	1.4e-04	2.6e-04	4.0e-04
2	Liver	intron excision ratio	chr10_83670746_83671692	0.02	0.02	7.3e-03	0.01	0.01	0	0	7.0e-02	3.1e-02	7.4e-02	7.7e-02
3	Adipose	alternative polyA	XM_006247399.5	0.02	0.01	4.6e-03	0.02	0.02	0.01	0.02	3.1e-03	2.0e-03	8.3e-03	3.9e-03
4	Liver	gene expression	Med1	0.04	0.05	2.9e-04	0.01	0	0.01	0	8.1e-03	7.3e-02	3.1e-02	1.0e-01
5	RMTg	gene expression	Med1	0.13	0.09	3.8e-03	0.07	0.06	0.03	0.06	7.3e-03	9.1e-03	4.7e-02	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.1	3.6	4.2	1.9	2.0	1.9	-2.1	-1.6
Area under the delay curve	0.8	0.9	1.5	1.0	1.0	1.0	-0.6	-1.2
BMI with tail	2.5	8.5	10.5	-3.2	-2.9	-3.0	3.1	2.3
BMI without tail	1.7	5.3	6.8	-2.6	-2.3	-2.5	2.1	2.1
Body weight	8.1	35.5	40.9	-6.4	-6.0	-6.2	5.6	5.5
Weight adjusted by age	0.2	0.3	0.3	-0.5	-0.5	-0.4	0.6	0.5
Bone surface	0.0	0.0	0.0	-0.2	0.1	-0.0	-0.2	0.2
Bone volume	0.1	0.1	0.3	0.1	0.4	0.3	-0.6	-0.2
Breakpoint value in progressive ratio session	1.2	1.5	2.0	-1.3	-1.3	-1.4	0.5	1.4
Number of licking bursts	0.2	0.3	0.6	0.4	0.6	0.6	-0.1	-0.8
Context. condit. distance diff. score	0.7	0.8	1.8	-0.6	-0.9	-0.7	1.4	0.6
Locomotion velocity, session 1	0.9	1.0	1.7	-1.0	-1.0	-1.0	0.5	1.3
Locomotion distance, session 1	3.7	4.7	6.1	-2.5	-2.2	-2.4	1.4	2.2
Locomotion velocity, session 2	0.5	0.6	1.2	-0.7	-0.7	-0.8	0.3	1.1
Locomotion distance, session 2	0.8	1.1	1.7	-1.3	-1.0	-1.2	0.2	1.3
Locomotion velocity, session 3	0.1	0.1	0.2	-0.2	-0.2	-0.3	-0.1	0.5
Locomotion distance, session 3	0.5	0.5	0.7	-0.8	-0.7	-0.8	0.5	0.8
Stereotopy head waving bouts, day 3	3.6	4.2	4.8	2.2	2.1	2.1	-1.7	-2.1
Stereotopy head waving duration, day 3	0.5	0.6	0.9	0.8	0.8	0.8	-0.4	-0.9
Locomotion velocity, session 7	1.0	1.1	1.4	-1.2	-1.1	-1.1	1.0	0.8
Locomotion distance, session 7	0.2	0.2	0.4	-0.5	-0.6	-0.5	0.6	0.1
Stereotopy head waving bouts, day 7	1.1	1.2	1.5	1.2	1.2	1.2	-0.7	-1.0
Stereotopy head waving duration, day 7	0.3	0.3	0.5	0.6	0.7	0.6	-0.4	-0.4
Locomotion velocity, session 8	7.3	8.7	9.6	-3.0	-3.1	-3.0	3.0	2.7
Locomotion distance, session 8	1.8	2.5	2.9	-1.7	-1.6	-1.7	1.4	1.6
Degree of sensitization distance	0.4	0.4	0.8	-0.5	-0.7	-0.6	0.9	0.2
Degree of sensitization stereotypy	1.3	1.4	1.9	1.3	1.3	1.4	-0.7	-1.2
Conditioned locomotion	0.3	0.3	0.4	0.7	0.5	0.5	-0.5	-0.5
Cocaine response after cond. corrected	1.2	1.5	2.2	1.2	1.5	1.5	-0.6	-1.2
Cocaine response after cond. not corrected	1.9	2.2	3.0	1.4	1.7	1.7	-0.6	-1.7
Cocaine response before conditioning	0.5	0.5	1.4	0.7	0.6	0.7	-0.1	-1.2
Saline control response	0.2	0.2	0.8	-0.3	-0.2	-0.1	0.9	-0.3
Bone: connectivity density	3.1	4.8	5.3	2.2	2.3	2.2	-2.3	-1.9
Bone: cortical apparent density	6.0	8.2	10.2	3.2	2.9	3.0	-2.7	-2.4
Bone: cortical area	0.1	0.2	0.3	0.5	0.5	0.6	-0.3	-0.5
Bone: cortical porosity	0.6	0.7	1.0	0.7	0.8	0.9	-0.4	-1.0
Bone: cortical porosity	0.5	0.5	1.2	0.6	0.7	0.8	-0.3	-1.1
Bone: cortical thickness	1.4	2.3	2.9	1.7	1.6	1.7	-1.1	-1.3
Bone: cortical thickness	5.3	6.2	6.8	2.6	2.5	2.5	-2.5	-2.4
Bone: cortical tissue density	6.0	8.2	10.2	3.2	2.9	3.0	-2.7	-2.4
Condit. Reinf. active minus inactive responses	0.7	0.8	1.0	1.0	0.9	0.8	-1.0	-0.7
Condit. Reinf. active-inactive response ratio	1.1	1.1	1.6	1.3	1.0	1.0	-1.0	-1.0
Condit. Reinf. active responses	0.9	1.1	1.3	1.1	1.0	1.1	-1.2	-0.8
Condit. Reinf. inactive responses	0.3	0.4	0.5	0.6	0.6	0.7	-0.6	-0.7
Incentive salience index mean	1.7	2.1	2.6	1.5	1.4	1.4	-1.6	-1.2
Condit. Reinf. lever presses	1.4	2.0	2.3	1.4	1.4	1.4	-1.5	-1.3
Condit. Reinf. active minus inactive responses	0.7	0.9	1.6	0.9	0.9	0.9	-1.3	-0.8
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.4	0.6	0.8	0.7	-1.2	-0.5
Condit. Reinf. active responses	1.1	1.6	2.6	1.1	1.1	1.1	-1.6	-1.2
Condit. Reinf. inactive responses	1.7	2.2	3.1	1.4	1.4	1.4	-1.5	-1.8
Condit. Reinf. lever presses	0.0	0.0	0.1	0.1	0.2	0.1	-0.2	-0.2
Condit. Reinf. lever reinforcers received	1.2	1.7	2.9	1.1	1.2	1.1	-1.7	-1.2
Conditioned reinforcement - actives	0.3	0.6	1.5	0.8	0.5	0.7	-0.0	-1.2
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.3	0.2	0.2	-0.5	-0.2
Conditioned locomotion	1.0	1.3	1.9	1.2	1.2	1.2	-0.7	-1.4
Patch foraging indifference point 0 sec	1.6	2.9	3.3	1.8	1.7	1.7	-1.7	-1.6
Patch foraging indifference point AUC	0.0	0.0	0.2	-0.0	0.0	0.0	-0.0	0.4
Delay disc. indifference point, 0s delay	2.1	2.3	2.5	1.5	1.6	1.5	-1.4	-1.5
Delay disc. indifference point, 16s delay	0.6	0.7	1.1	1.1	0.8	0.9	-0.5	-0.8
Delay disc. indifference point, 2s delay	2.0	2.2	3.3	1.4	1.5	1.6	-1.1	-1.8
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.2	0.1	0.1	0.6	-0.1
Delay disc. indifference point, 4s delay	0.8	0.9	1.1	0.8	1.0	1.0	-1.1	-0.7
Delay disc. indifference point, 8s delay	0.4	0.5	1.3	0.6	0.6	0.6	-0.2	-1.1
Indifference point function ln k	0.0	0.0	0.1	0.2	0.1	0.1	0.3	-0.3
Indifference point function log k	0.0	0.0	0.1	0.2	0.1	0.1	0.3	-0.3
Patch foraging total patch changes 0 sec	1.0	1.8	2.1	1.5	1.3	1.3	-1.4	-1.2
Patch foraging total patch changes 12 sec	4.5	5.8	6.8	2.4	2.5	2.4	-2.6	-2.1
Patch foraging total patch changes 18 sec	0.3	0.4	0.6	0.7	0.6	0.7	-0.8	-0.3
Patch foraging total patch changes 24 sec	1.1	1.8	2.4	1.5	1.5	1.5	-1.1	-1.1
Patch foraging total patch changes 6 sec	1.5	2.3	3.8	1.5	1.5	1.5	-1.9	-1.0
Patch foraging time to switch 0 sec	0.0	0.1	0.2	0.2	0.2	0.1	-0.4	-0.1
Patch foraging water rate 0 sec	0.0	0.0	0.1	0.2	0.2	0.1	-0.3	-0.0
Patch foraging water rate 12 sec	0.2	0.4	0.6	-0.5	-0.6	-0.6	0.6	0.8
Patch foraging water rate 18 sec	0.4	0.6	1.0	0.7	0.8	0.7	-0.5	-1.0
Patch foraging water rate 24 sec	0.4	0.6	1.2	0.7	0.7	0.6	-1.1	-0.8
Patch foraging water rate 6 sec	1.0	1.5	2.0	1.2	1.2	1.2	-1.4	-1.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.0	-0.3	-0.2	-0.2	0.5
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	0.3
Distance traveled after self-admin	0.7	0.9	1.3	-1.1	-1.1	-1.2	0.5	0.7
Extensor digitorum longus weight	9.3	36.7	40.1	-6.0	-6.2	-6.0	6.3	5.8
Bone: elastic displacement	0.0	0.0	0.0	0.1	0.2	0.2	0.1	-0.1
Bone: elastic work	0.0	0.0	0.1	-0.0	0.2	0.1	-0.2	0.1
Bone: endosteal estimation	2.2	4.9	5.9	-2.4	-2.3	-2.3	2.1	1.9
Bone: endosteal perimeter	1.8	3.9	4.9	-2.2	-2.1	-2.2	1.6	1.8
Epididymis fat weight	0.1	0.4	0.6	-0.8	-0.7	-0.6	0.8	0.3
Delta time in closed arm before/after self-admin	4.5	4.2	5.0	-2.2	-2.1	-2.2	1.9	1.9
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.1	0.1	0.1	0.3	-0.0
Diff in mean of infusions in LGA sessions	0.1	0.2	0.3	-0.5	-0.5	-0.5	0.2	-0.0
Delay discount exponential model param	0.5	0.6	1.0	-0.7	-0.7	-0.8	0.4	1.0
Extinction: sum of active levers before priming	1.1	1.3	2.9	-1.1	-1.0	-1.0	1.7	0.4
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.2	0.3	0.0	-0.3	-0.1
Bone: final force	0.8	1.3	1.9	1.1	1.2	1.2	-0.8	-1.4
Bone: final moment	0.6	1.0	1.6	0.9	1.1	1.1	-0.6	-1.3
Food consumed during 24 hour testing period	0.8	1.1	1.3	-1.1	-1.1	-1.1	0.9	1.1
Glucose	0.2	0.4	0.6	0.4	0.7	0.7	-0.1	-0.8
Heart weight	3.4	5.3	6.0	-2.4	-2.4	-2.4	2.2	2.1
Delay discount hyperbolic model param	0.5	0.5	0.9	-0.7	-0.7	-0.7	0.4	1.0
Intermittent access intake day 1-15 change	0.1	0.1	0.3	-0.4	-0.4	-0.5	-0.1	0.2
Intermittent access intake escalation	0.1	0.1	0.3	-0.4	-0.4	-0.5	-0.0	0.1
Intermittent access intake escalation 2	0.5	0.6	0.9	-0.9	-0.8	-0.9	0.6	0.6
Intermitt. access day 1 inactive lever presses	0.3	1.1	2.8	0.8	0.9	0.7	-1.7	-0.9
Intermitt. access day 15 inactive lever presses	0.7	1.4	2.2	1.2	1.3	1.1	-1.5	-0.8
Intermitt. access escalation Index	1.3	1.8	2.5	-1.3	-1.3	-1.3	1.6	1.3
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.1	-0.0	0.1	-0.4	-0.1
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.3	-0.5	-0.4	-0.1	0.2
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.2	0.1	-0.0	-0.0	-0.4	-0.2
Intermittent access total infusions	0.1	0.1	0.1	-0.2	-0.3	-0.3	-0.2	0.2
Intermittent access day 1 locomotion	0.1	0.2	0.2	0.4	0.3	0.4	-0.4	-0.4
Intermittent access day 15 total locomotion	0.3	0.6	0.9	0.7	0.8	0.8	-0.6	-0.9
Intermittent access total locomotion	1.1	1.3	1.4	1.2	1.1	1.1	-1.0	-1.2
Intermittent access standard deviation	0.3	0.6	2.2	0.6	0.5	0.4	-1.5	-0.4
Left kidney weight	0.9	4.1	5.4	-2.1	-2.1	-2.2	1.3	2.3
Right kidney weight	0.1	0.4	0.8	-0.8	-0.6	-0.7	0.0	0.9
Cocaine induced anxiety	3.6	5.2	6.0	-2.4	-2.3	-2.4	2.1	2.1
Post-drug Anxiety	1.1	1.2	1.5	-1.1	-1.2	-1.2	1.1	0.8
Baseline Anxiety	3.2	3.7	4.3	2.0	1.9	2.1	-1.4	-2.0
Tail length	1.2	4.8	6.9	-2.2	-2.2	-2.3	1.6	2.6
Length with tail	4.2	18.3	20.5	-4.5	-4.4	-4.5	3.4	4.4
Length without tail	3.5	11.2	12.6	-3.6	-3.4	-3.4	3.1	3.2
Times rat made contact with spout	0.9	1.1	1.3	0.9	1.2	1.1	-1.2	-0.8
Lifetime Intake	0.0	0.0	0.2	0.0	-0.2	-0.1	-0.4	0.1
Liver weight, left	0.3	0.4	0.7	-0.7	-0.6	-0.6	0.8	0.6
Liver weight, right	0.4	0.7	0.8	0.9	0.8	0.8	-0.9	-0.7
Locomotor activity	0.4	0.6	0.8	0.7	0.9	0.9	-0.5	-0.9
Locomotor testing distance	2.4	4.3	6.1	2.1	2.1	2.1	-1.6	-2.5
Locomotor testing rearing	4.7	9.4	10.1	3.2	3.1	3.0	-3.2	-2.8
Locomotion in novel chamber	4.6	5.9	7.2	2.4	2.7	2.6	-2.7	-1.5
Locomotion in novel chamber post-restriction	0.2	0.3	0.7	0.2	0.5	0.4	-0.8	-0.3
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	-0.5	-0.4	-0.4	0.1	0.6
Change in fecal boli incidents, locomotor task	0.3	0.3	0.8	0.5	0.5	0.5	0.2	-0.9
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.0	1.0	0.8	0.9	-0.2	-0.9
Bouts of movement, locomotor time 1	0.5	0.6	0.7	-0.8	-0.9	-0.9	0.8	0.5
Total resting periods, locomotor time 1	0.9	1.0	1.2	-1.1	-1.1	-1.0	1.1	0.7
Rest time, locomotor task time 1	0.0	0.0	0.0	-0.2	-0.1	-0.2	-0.2	0.1
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.3	0.2	0.3	-0.3	-0.4
Vertical activity count, locomotor time 1	0.1	0.2	0.4	-0.5	-0.5	-0.4	0.6	0.1
Time >=10cm from walls, locomotor time 2	1.1	1.7	2.2	1.4	1.3	1.5	-0.8	-1.4
Bouts of movement, locomotor time 2	0.1	0.2	0.4	0.6	0.4	0.4	-0.5	-0.4
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.4	0.1	0.1	-0.3	-0.2
Rest time, locomotor task time 2	1.0	1.2	1.4	-1.2	-1.1	-1.2	1.0	1.0
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.1	0.0
Vertical activity count, locomotor time 2	0.1	0.2	0.4	-0.4	-0.4	-0.3	0.7	0.0
Light reinforcement 1	1.4	3.3	4.3	1.8	1.8	1.7	-2.1	-1.7
Light reinforcement 2	0.4	0.6	0.8	0.6	0.9	0.8	-0.7	-0.8
Bone: marrow area	2.1	4.6	5.6	-2.4	-2.2	-2.3	2.1	1.8
Bone: maximum diameter	0.0	0.0	0.0	0.0	-0.0	0.0	-0.2	-0.0
Bone: maximum force	0.0	0.0	0.1	-0.1	-0.1	-0.0	0.3	-0.2
Bone: maximum moment	0.0	0.1	0.2	-0.2	-0.2	-0.1	0.5	-0.1
Mean time between licks in bursts	1.0	2.5	3.0	-1.7	-1.6	-1.7	1.4	1.5
Mean num. licks in bursts	0.1	0.1	0.4	0.3	0.3	0.2	-0.7	-0.0
Cd content in liver	1.4	1.6	1.8	-1.3	-1.4	-1.3	1.3	0.9
Co content in liver	2.0	2.3	2.6	-1.4	-1.6	-1.6	1.4	1.5
Cu content in liver	0.3	0.4	1.1	-0.4	-0.5	-0.6	-0.3	1.0
Fe content in liver	2.1	2.5	3.2	-1.8	-1.6	-1.7	1.1	1.7
K content in liver	0.4	0.3	0.9	0.5	0.5	0.4	-1.0	0.1
Mg content in liver	0.4	0.4	0.7	0.9	0.7	0.6	-0.8	-0.1
Mn content in liver	0.5	0.6	1.3	0.9	0.7	0.6	-1.1	-0.2
Na content in liver	0.1	0.1	0.4	0.1	0.4	0.3	-0.6	-0.2
Rb content in liver	1.8	2.0	2.2	1.4	1.5	1.4	-1.5	-1.3
Se content in liver	5.2	6.2	8.4	2.6	2.5	2.4	-2.9	-1.8
Sr content in liver	0.6	0.5	1.0	-0.5	-0.8	-0.8	0.5	1.0
Zn content in liver	2.6	2.9	4.4	1.7	1.7	1.6	-2.1	-1.4
Bone: minimum diameter	0.6	1.0	1.2	-1.1	-1.1	-1.0	1.0	0.8
Time in familiar zone, hab. session 1	0.3	0.2	0.6	0.2	0.5	0.5	-0.4	-0.8
Time in novel zone, hab. session 1	0.7	0.7	1.2	1.1	0.9	0.9	-0.5	-0.8
Total zone transitions, hab. session 1	2.2	3.0	3.3	-1.8	-1.8	-1.8	1.5	1.8
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.1	0.1
Locomotion velocity, hab. session 1	0.5	0.7	0.9	-0.9	-0.9	-0.9	0.7	0.8
Time in familiar zone, hab. session 2	0.4	0.5	0.9	0.5	0.7	0.6	-0.5	-1.0
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	0.3	0.3	-0.4	-0.0
Total zone transitions, hab. session 2	0.9	1.1	1.5	-1.1	-1.1	-1.0	1.2	0.8
Total locomotion distance, hab. session 2	0.2	0.3	0.4	-0.7	-0.5	-0.6	0.6	0.2
Locomotion velocity, hab. session 2	0.5	0.6	0.8	-0.9	-0.8	-0.8	0.9	0.4
Novel to familiar place preference ratio	1.2	1.3	1.7	-1.0	-1.2	-1.1	1.1	1.3
Novelty place preference	0.8	0.8	1.0	-0.7	-1.0	-0.9	1.0	1.0
Time in novel zone, NPP test	0.2	0.3	0.6	-0.2	-0.5	-0.4	0.8	0.5
Total zone transitions, NPP test	0.4	0.6	1.0	-1.0	-0.8	-0.8	0.6	0.7
Total locomotion distance, NPP test	0.0	0.0	0.1	-0.3	-0.0	-0.1	-0.0	0.0
Locomotion velocity, NPP test	0.3	0.4	0.7	-0.8	-0.7	-0.7	0.2	0.7
Intraocular pressure	1.7	2.4	3.0	-1.7	-1.7	-1.7	1.5	1.1
Delta distance traveled before/after self-admin	1.0	1.0	1.9	-0.9	-1.0	-1.0	1.4	0.6
Delta ambulatory time before/after self-admin	0.7	0.9	2.2	-0.8	-0.8	-0.8	1.5	0.3
Parametrial fat weight	0.3	0.8	1.2	0.7	0.8	0.8	-0.9	-1.1
Pavlov. Cond. lever latency	2.6	3.3	3.6	-1.6	-1.8	-1.8	1.9	1.9
Pavlov. Cond. magazine entry latency	10.5	13.5	14.9	3.6	3.7	3.7	-3.9	-3.5
Pavlov. Cond. change in total contacts	10.6	11.2	12.1	3.5	3.4	3.4	-3.4	-3.0
Pavlov. Cond. index score	9.6	12.0	12.7	3.3	3.5	3.5	-3.6	-3.4
Pavlov. Cond. latency score	7.3	9.2	9.8	2.9	3.1	3.1	-3.1	-3.0
Pavlov. Cond. lever contacts	3.4	4.0	4.6	1.8	2.0	2.0	-2.1	-2.0
Pavlov. Cond. magazine entry number	14.8	18.7	19.8	-4.3	-4.5	-4.4	4.3	4.1
Pavlov. Cond. intertrial magazine entries	1.5	1.8	2.3	-1.2	-1.3	-1.3	1.5	1.4
Pavlov. Cond. lever-magazine prob. diff.	11.4	14.1	15.0	3.6	3.8	3.8	-3.9	-3.7
Pavlov. Cond. response bias	11.5	14.2	14.8	3.7	3.8	3.8	-3.9	-3.6
Pavlov. Cond. lever latency	0.3	0.5	0.9	-0.5	-0.7	-0.6	1.0	0.5
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.3	-0.2	-0.2	0.2	0.3
Pavlov. Cond. change in total contacts	0.5	0.8	1.4	0.9	0.9	0.9	-1.2	-0.7
Pavlov. Cond. index score	0.1	0.2	0.4	0.3	0.4	0.4	-0.6	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	0.2	0.4	0.4	-0.4	-0.3
Pavlov. Cond. lever contacts	0.5	0.6	1.1	0.6	0.8	0.7	-1.0	-0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.4	0.4
Pavlov. Cond. intertrial magazine entries	1.4	2.1	2.4	-1.2	-1.5	-1.5	1.6	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.1	0.3	0.2	-0.5	-0.2
Pavlov. Cond. response bias	0.8	1.1	2.0	0.9	1.1	1.0	-1.4	-0.9
Time in closed arm before self-admin	2.1	2.7	3.2	1.8	1.6	1.6	-1.7	-1.5
Time in closed arm after self-admin	0.2	0.2	0.4	-0.3	-0.5	-0.5	-0.1	0.6
Time in open arm before self-admin	2.6	2.9	3.2	-1.8	-1.7	-1.7	1.6	1.7
Time in open arm after self-admin	0.5	0.5	0.9	-0.7	-0.6	-0.6	0.9	0.8
Bone: periosteal estimation	0.2	0.5	0.7	-0.8	-0.8	-0.7	0.7	0.5
Bone: periosteal perimeter	0.8	1.4	2.0	-1.4	-1.3	-1.3	0.9	1.0
Bone: post-yield work	0.9	1.3	1.6	-1.2	-1.3	-1.2	1.2	0.8
Progressive ratio test 1 active lever presses	0.2	0.3	0.6	0.6	0.4	0.6	-0.2	-0.8
Progressive ratio test 1 breakpoint	0.2	0.3	0.7	0.5	0.4	0.5	-0.1	-0.8
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.3	0.1	0.1	-0.5	-0.3
Progressive ratio test 2 active lever presses	0.6	0.7	1.2	0.9	0.8	0.8	-1.1	-0.7
Progressive ratio test 2 breakpoint	0.7	0.8	1.3	0.9	0.8	0.9	-1.2	-0.7
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.4	-0.1	-0.1	-0.1	-0.6	0.5
Incentive Sensitization - Responses	0.9	1.3	2.5	1.1	1.1	1.1	-1.6	-0.7
Incentive Sensitization - Breakpoint	0.8	1.1	2.3	1.0	1.0	1.0	-1.5	-0.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.2	0.3	0.3	-0.1	-0.4
Progressive ratio	0.0	0.0	0.0	-0.0	-0.1	-0.0	-0.2	0.1
Food seeking constrained by brief footshock	0.4	0.4	0.5	0.7	0.7	0.7	-0.6	-0.7
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.4	0.4	0.4	0.0	-0.5
Retroperitoneal fat weight	0.1	0.4	0.6	0.6	0.5	0.5	-0.6	-0.8
Reaction time number correct	0.6	1.2	1.5	-1.2	-1.2	-1.1	0.9	0.9
Reaction time mean minus median	0.1	0.2	0.6	-0.4	-0.5	-0.4	0.7	0.2
Reaction time mean minus median AUC	0.1	0.2	0.4	0.4	0.3	0.4	0.2	-0.6
Reaction time num false alarms	0.6	0.8	1.2	0.7	0.9	0.9	-1.1	-0.9
Reaction time num false alarms AUC	0.3	0.5	0.8	0.5	0.7	0.7	-0.9	-0.8
Reaction time trials correct on left	0.6	1.2	1.5	-1.2	-1.2	-1.1	0.9	0.9
Reaction time trials on left	0.6	1.1	1.4	-1.2	-1.1	-1.1	0.9	0.9
Reaction time mean	0.1	0.1	0.2	0.4	0.3	0.3	-0.4	0.1
Reaction time mean AUC	0.1	0.1	0.2	0.3	0.2	0.2	-0.4	0.2
Median of all reaction times	0.4	0.6	1.1	0.9	0.8	0.8	-1.1	-0.2
Reaction time omissions	0.3	0.5	0.6	0.7	0.7	0.6	-0.8	-0.7
Reaction time false alarm rate	1.1	1.5	1.6	1.2	1.2	1.2	-1.3	-1.2
Reaction time premature initiation rate	0.2	0.3	0.7	0.5	0.5	0.4	-0.3	-0.8
Reaction time premature initiations	0.1	0.2	0.2	-0.5	-0.5	-0.4	0.5	-0.0
Std. dev. reaction times	0.0	0.0	0.0	0.1	0.1	0.1	0.1	-0.1
Reaction time trials completed	0.6	1.1	1.4	-1.2	-1.1	-1.1	0.9	0.9
Reaction time trials AUC	0.5	1.0	1.2	-1.1	-1.1	-1.0	0.9	0.8
Run reversals in cocaine runway, females	1.6	1.6	2.0	-1.2	-1.4	-1.3	1.4	1.1
Run reversals in cocaine runway, males	0.2	0.2	0.3	0.4	0.6	0.5	-0.4	-0.5
Latency to leave start box in cocaine runway	2.0	2.3	3.3	-1.6	-1.6	-1.6	0.7	1.8
Latency to leave start box in cocaine runway, F	2.8	3.2	4.3	-1.9	-1.9	-1.8	1.2	2.1
Latency to leave start box in cocaine runway, M	0.2	0.2	0.6	-0.1	-0.0	-0.2	-0.8	0.6
Std. dev. time between licks in bursts	0.2	0.3	0.5	-0.6	-0.5	-0.6	0.2	0.7
Total sessions with >9 infusions	0.0	0.1	0.1	0.3	0.1	0.2	-0.3	-0.2
Short access day 1 total inactive lever presses	1.3	1.7	3.1	1.2	1.2	1.1	-1.8	-1.2
Short access day 10 total inactive lever presses	0.2	0.5	0.7	-0.8	-0.7	-0.8	0.2	0.8
Short access day 1 total infusions	0.2	0.2	0.7	0.5	0.3	0.4	-0.8	-0.2
Short access day 10 total infusions	0.3	0.4	0.8	0.6	0.5	0.5	-0.9	-0.5
Short access total infusions	0.1	0.1	0.5	0.2	0.1	0.1	-0.7	0.0
Short access day 1 locomotion	0.9	1.1	1.6	1.1	1.0	1.0	-1.3	-0.9
Short access day 10 total locomotion	1.8	3.3	3.5	1.8	1.9	1.8	-1.8	-1.9
Short access total locomotion	0.3	0.4	0.7	0.6	0.6	0.6	-0.8	-0.6
One hour access (0.3 mA shock)	0.1	0.1	0.4	-0.2	-0.5	-0.2	0.6	-0.2
Compulsive drug intake	0.1	0.1	0.2	0.4	0.1	0.3	0.5	-0.4
One hour access (shock baseline)	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.0	0.2
Social response proportion	0.1	0.1	0.3	-0.1	-0.1	-0.1	0.6	-0.1
Social responses	0.0	0.0	0.1	0.0	0.3	0.2	-0.2	-0.2
Social time	0.1	0.1	0.2	-0.5	-0.2	-0.2	0.3	0.1
Soleus weight	0.2	0.6	1.1	0.5	0.8	0.8	0.5	-1.1
Bone: stiffness	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0	-0.2
Tibialis anterior weight	1.6	5.3	5.8	-2.4	-2.2	-2.2	2.3	2.3
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	0.3	0.4	0.3	-0.1	-0.7
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.1	0.2	0.2	-0.0	0.1
Time to tail flick, test, before self-admin	1.0	1.1	2.4	-0.9	-0.9	-0.9	1.6	0.7
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.1	0.4	0.2	-0.6	-0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.2	0.3	0.4	0.5	0.6	-0.5	-0.4
Delta time to tail flick, test, before/after SA	2.8	2.8	4.4	1.5	1.7	1.6	-2.1	-1.4
Tibia length	1.1	3.2	4.0	-2.0	-1.7	-1.7	2.0	1.5
Ambulatory time before self-admin	0.3	0.4	0.5	-0.7	-0.6	-0.7	-0.1	0.7
Ambulatory time after self-admin	2.3	2.7	3.4	-1.9	-1.7	-1.8	1.3	1.4
Bone: tissue strength	0.9	0.9	2.0	-0.8	-0.9	-0.8	1.4	0.8
Total heroin consumption	1.0	1.1	2.8	0.8	1.1	0.9	-1.7	-0.6
Bone: trabecular number	5.4	8.9	9.6	2.9	3.1	3.0	-3.0	-2.8
Bone: trabecular spacing	1.5	2.0	2.7	-1.6	-1.5	-1.4	1.5	1.0
Bone: trabecular thickness	0.1	0.1	0.2	0.2	0.2	0.2	-0.4	-0.0
Bone: trabecular tissue density	0.1	0.1	0.3	0.4	-0.0	0.1	0.6	0.1
Water consumed over 24 hours	0.0	0.1	0.1	-0.3	-0.2	-0.2	0.3	0.1
Number of responses in last shaping day	0.1	0.1	0.3	0.1	0.1	-0.0	-0.4	0.5