Mcrs1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Mcrs1 0.05 0.04 5.6e-07 0.04 0.05 0.04 0.04 1.3e-05 4.8e-06 9.5e-06 1.5e-05
2 BLA gene expression Mcrs1 0.05 0.04 6.6e-03 0.04 0.04 0.03 0.03 3.7e-03 5.5e-03 1.2e-02 8.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density10.517.618.24.3-4.1
Area under the delay curve1.21.31.51.0-1.2
BMI with tail4.514.714.83.8-3.8
BMI without tail0.00.00.1-0.1-0.2
Body weight6.326.226.45.1-5.1
Weight adjusted by age1.72.02.11.4-1.4
Bone surface12.522.022.64.8-4.6
Bone volume9.916.917.14.1-4.1
Breakpoint value in progressive ratio session0.30.30.30.5-0.6
Number of licking bursts1.21.41.7-1.01.3
Context. condit. distance diff. score0.20.20.30.5-0.5
Locomotion velocity, session 11.82.02.2-1.31.5
Locomotion distance, session 12.83.63.6-1.91.9
Locomotion velocity, session 20.20.30.3-0.50.5
Locomotion distance, session 22.63.73.8-1.92.0
Locomotion velocity, session 34.85.65.8-2.32.4
Locomotion distance, session 34.75.25.4-2.32.2
Stereotopy head waving bouts, day 30.60.70.91.0-0.6
Stereotopy head waving duration, day 30.20.30.40.7-0.4
Locomotion velocity, session 70.91.01.3-0.81.1
Locomotion distance, session 72.73.43.7-1.81.9
Stereotopy head waving bouts, day 70.70.70.80.9-0.8
Stereotopy head waving duration, day 71.11.31.41.2-1.1
Locomotion velocity, session 80.10.10.1-0.10.4
Locomotion distance, session 81.31.81.9-1.31.4
Degree of sensitization distance0.20.20.30.6-0.4
Degree of sensitization stereotypy0.20.20.30.4-0.5
Conditioned locomotion0.00.00.00.10.2
Cocaine response after cond. corrected0.00.00.0-0.0-0.1
Cocaine response after cond. not corrected0.40.40.5-0.70.5
Cocaine response before conditioning3.34.04.2-2.02.0
Saline control response0.00.10.10.3-0.0
Bone: connectivity density6.910.911.83.4-3.2
Bone: cortical apparent density0.20.30.3-0.60.5
Bone: cortical area8.813.313.93.7-3.6
Bone: cortical porosity0.30.30.4-0.60.5
Bone: cortical porosity0.60.60.7-0.90.7
Bone: cortical thickness2.74.44.82.2-2.0
Bone: cortical thickness0.00.00.00.10.1
Bone: cortical tissue density0.30.40.4-0.70.6
Condit. Reinf. active minus inactive responses0.10.10.1-0.30.2
Condit. Reinf. active-inactive response ratio0.20.30.30.5-0.5
Condit. Reinf. active responses0.70.90.9-0.90.9
Condit. Reinf. inactive responses3.13.73.7-1.91.9
Incentive salience index mean0.00.00.00.1-0.1
Condit. Reinf. lever presses0.20.30.40.4-0.6
Condit. Reinf. active minus inactive responses0.00.00.00.1-0.2
Condit. Reinf. active-inactive response ratio0.10.10.1-0.30.2
Condit. Reinf. active responses0.10.10.1-0.30.2
Condit. Reinf. inactive responses0.60.70.8-0.90.8
Condit. Reinf. lever presses0.00.00.00.00.1
Condit. Reinf. lever reinforcers received0.40.50.5-0.70.7
Conditioned reinforcement - actives1.51.51.7-1.31.1
Conditioned reinforcement - inactives2.42.72.8-1.71.6
Conditioned locomotion0.50.60.7-0.70.8
Patch foraging indifference point 0 sec3.96.26.9-2.32.6
Patch foraging indifference point AUC0.40.50.7-0.60.8
Delay disc. indifference point, 0s delay1.31.41.61.3-1.1
Delay disc. indifference point, 16s delay1.01.01.11.0-1.0
Delay disc. indifference point, 2s delay2.22.42.81.4-1.7
Delay disc. indifference point, 24s delay1.21.21.21.1-1.1
Delay disc. indifference point, 4s delay0.60.60.70.7-0.9
Delay disc. indifference point, 8s delay2.52.62.71.6-1.6
Indifference point function ln k5.17.17.62.6-2.8
Indifference point function log k5.17.17.62.6-2.8
Patch foraging total patch changes 0 sec3.75.96.6-2.32.6
Patch foraging total patch changes 12 sec4.05.25.9-2.12.4
Patch foraging total patch changes 18 sec6.48.29.2-2.73.0
Patch foraging total patch changes 24 sec3.64.55.1-2.02.3
Patch foraging total patch changes 6 sec4.46.57.2-2.42.7
Patch foraging time to switch 0 sec2.33.53.7-1.91.8
Patch foraging water rate 0 sec2.94.64.82.2-2.1
Patch foraging water rate 12 sec3.55.45.92.4-2.2
Patch foraging water rate 18 sec0.30.40.50.6-0.7
Patch foraging water rate 24 sec4.05.65.72.3-2.4
Patch foraging water rate 6 sec4.66.76.82.6-2.6
Seeking ratio, delayed vs. immediate footshock0.30.30.40.6-0.5
Distance traveled before self-admin1.31.41.6-1.31.1
Distance traveled after self-admin0.30.30.4-0.50.6
Extensor digitorum longus weight4.517.618.74.1-4.3
Bone: elastic displacement4.95.55.7-2.32.4
Bone: elastic work0.10.10.10.2-0.4
Bone: endosteal estimation8.518.618.84.3-4.3
Bone: endosteal perimeter7.014.515.03.9-3.7
Epididymis fat weight0.10.20.30.5-0.3
Delta time in closed arm before/after self-admin0.10.10.20.50.0
Delta time in open arm before/after self-admin4.34.24.5-2.12.0
Diff in mean of infusions in LGA sessions2.32.63.21.4-1.8
Delay discount exponential model param1.21.31.5-1.01.2
Extinction: sum of active levers before priming0.70.70.70.8-0.8
Active lever presses in extinction session 60.30.30.40.6-0.5
Bone: final force11.819.119.44.3-4.4
Bone: final moment12.920.921.34.5-4.6
Food consumed during 24 hour testing period1.82.12.31.5-1.4
Glucose0.10.10.2-0.10.4
Heart weight0.10.10.10.3-0.3
Delay discount hyperbolic model param1.31.31.6-1.01.3
Intermittent access intake day 1-15 change1.31.21.3-1.21.1
Intermittent access intake escalation0.70.70.8-0.90.7
Intermittent access intake escalation 21.21.21.4-1.21.0
Intermitt. access day 1 inactive lever presses1.51.62.0-1.41.0
Intermitt. access day 15 inactive lever presses0.70.81.0-1.00.8
Intermitt. access escalation Index0.30.20.3-0.60.4
Intermittent access day 1 total infusions1.11.31.6-1.31.0
Intermittent access day 15 total infusions2.73.03.4-1.81.6
Intermittent access terminal intake (last 3 days)2.93.13.5-1.91.7
Intermittent access total infusions2.52.73.3-1.81.5
Intermittent access day 1 locomotion1.01.01.1-1.11.0
Intermittent access day 15 total locomotion1.92.02.0-1.41.4
Intermittent access total locomotion4.04.64.6-2.12.1
Intermittent access standard deviation0.30.30.4-0.60.4
Left kidney weight0.71.92.41.2-1.6
Right kidney weight2.98.08.52.7-2.9
Cocaine induced anxiety1.71.92.61.1-1.6
Post-drug Anxiety6.57.28.32.5-2.9
Baseline Anxiety0.91.01.01.0-1.0
Tail length0.10.20.3-0.60.2
Length with tail2.17.88.32.7-2.9
Length without tail7.315.916.74.1-3.9
Times rat made contact with spout0.10.10.1-0.30.3
Lifetime Intake2.83.13.6-1.91.6
Liver weight, left1.82.93.01.7-1.7
Liver weight, right1.72.82.91.6-1.7
Locomotor activity1.11.72.1-1.51.1
Locomotor testing distance3.25.35.8-2.42.2
Locomotor testing rearing2.43.74.1-2.01.8
Locomotion in novel chamber1.11.31.51.1-1.2
Locomotion in novel chamber post-restriction0.10.10.20.3-0.4
Fecal boli incidents, locomotor time 12.02.12.5-1.61.3
Change in fecal boli incidents, locomotor task1.31.21.41.2-1.0
Time >=10cm from walls, locomotor time 10.00.00.00.20.1
Bouts of movement, locomotor time 10.00.00.00.10.1
Total resting periods, locomotor time 10.40.40.6-0.50.8
Rest time, locomotor task time 10.70.71.0-0.71.0
Distance moved, locomotor task time 10.00.00.00.1-0.0
Vertical activity count, locomotor time 11.51.61.91.1-1.4
Time >=10cm from walls, locomotor time 20.40.50.7-0.80.5
Bouts of movement, locomotor time 22.83.13.21.8-1.7
Total resting periods, locomotor time 23.13.33.71.9-1.7
Rest time, locomotor task time 20.10.10.1-0.00.4
Distance moved, locomotor task time 20.00.00.0-0.20.1
Vertical activity count, locomotor time 20.10.10.10.1-0.3
Light reinforcement 12.44.44.9-2.22.0
Light reinforcement 20.40.50.8-0.90.4
Bone: marrow area8.217.918.24.3-4.2
Bone: maximum diameter2.85.25.62.4-2.2
Bone: maximum force16.829.129.45.4-5.4
Bone: maximum moment18.131.231.75.5-5.6
Mean time between licks in bursts0.00.00.0-0.1-0.0
Mean num. licks in bursts0.30.30.50.4-0.7
Cd content in liver0.90.91.0-0.91.0
Co content in liver0.80.91.1-1.00.9
Cu content in liver0.40.50.60.8-0.6
Fe content in liver0.60.70.7-0.80.8
K content in liver0.00.00.10.3-0.1
Mg content in liver0.10.10.2-0.30.4
Mn content in liver0.10.10.20.4-0.4
Na content in liver0.10.10.1-0.30.4
Rb content in liver1.11.41.7-1.01.3
Se content in liver1.41.82.2-1.21.5
Sr content in liver0.10.10.10.3-0.1
Zn content in liver2.83.13.3-1.71.8
Bone: minimum diameter9.718.218.24.3-4.3
Time in familiar zone, hab. session 10.10.10.1-0.40.3
Time in novel zone, hab. session 10.20.10.20.4-0.3
Total zone transitions, hab. session 10.20.30.4-0.60.5
Total locomotion distance, hab. session 10.00.00.1-0.00.3
Locomotion velocity, hab. session 10.00.00.00.10.1
Time in familiar zone, hab. session 20.70.80.90.8-0.9
Time in novel zone, hab. session 20.70.70.9-0.70.9
Total zone transitions, hab. session 20.30.40.4-0.60.6
Total locomotion distance, hab. session 20.20.20.3-0.30.6
Locomotion velocity, hab. session 20.10.10.1-0.20.4
Novel to familiar place preference ratio1.71.81.91.4-1.3
Novelty place preference1.11.21.31.1-1.0
Time in novel zone, NPP test0.90.91.01.0-0.9
Total zone transitions, NPP test1.82.62.7-1.61.6
Total locomotion distance, NPP test2.43.33.7-1.71.9
Locomotion velocity, NPP test1.42.02.3-1.31.5
Intraocular pressure7.310.211.0-3.33.1
Delta distance traveled before/after self-admin0.10.10.10.3-0.1
Delta ambulatory time before/after self-admin0.00.00.00.1-0.0
Parametrial fat weight2.44.64.8-2.12.2
Pavlov. Cond. lever latency0.10.10.10.3-0.1
Pavlov. Cond. magazine entry latency0.20.20.30.3-0.6
Pavlov. Cond. change in total contacts0.20.20.30.2-0.6
Pavlov. Cond. index score0.10.10.10.1-0.4
Pavlov. Cond. latency score0.00.00.00.0-0.2
Pavlov. Cond. lever contacts0.30.30.5-0.70.4
Pavlov. Cond. magazine entry number0.00.00.00.10.2
Pavlov. Cond. intertrial magazine entries1.21.52.0-1.01.4
Pavlov. Cond. lever-magazine prob. diff.0.30.30.40.5-0.7
Pavlov. Cond. response bias0.00.00.0-0.2-0.1
Pavlov. Cond. lever latency0.30.40.60.4-0.8
Pavlov. Cond. magazine entry latency0.40.50.80.9-0.4
Pavlov. Cond. change in total contacts0.81.11.51.2-0.9
Pavlov. Cond. index score0.10.10.20.50.1
Pavlov. Cond. latency score0.10.10.20.50.1
Pavlov. Cond. lever contacts0.40.60.8-0.60.9
Pavlov. Cond. magazine entry number0.91.21.7-1.30.8
Pavlov. Cond. intertrial magazine entries4.45.76.5-2.52.2
Pavlov. Cond. lever-magazine prob. diff.0.20.30.60.8-0.2
Pavlov. Cond. response bias0.10.20.3-0.20.6
Time in closed arm before self-admin1.51.81.81.3-1.4
Time in closed arm after self-admin0.60.60.80.9-0.6
Time in open arm before self-admin0.60.70.70.8-0.8
Time in open arm after self-admin0.20.20.3-0.50.2
Bone: periosteal estimation12.024.725.35.0-4.9
Bone: periosteal perimeter10.317.217.84.2-4.1
Bone: post-yield work10.013.613.63.7-3.7
Progressive ratio test 1 active lever presses6.16.46.7-2.62.5
Progressive ratio test 1 breakpoint5.65.86.1-2.52.4
Progressive ratio test 1 inactive lever presses3.03.34.1-2.01.6
Progressive ratio test 2 active lever presses2.42.53.1-1.71.4
Progressive ratio test 2 breakpoint2.93.33.9-2.01.6
Progressive ratio test 2 inactive lever presses2.12.42.9-1.71.4
Incentive Sensitization - Responses0.10.10.20.1-0.4
Incentive Sensitization - Breakpoint0.00.00.1-0.0-0.3
Sum of active levers in priming session hrs 5-60.40.40.8-0.20.9
Progressive ratio0.20.20.2-0.40.5
Food seeking constrained by brief footshock0.60.80.8-0.90.9
Seeking ratio, punishment vs. effort0.00.00.00.0-0.1
Retroperitoneal fat weight0.93.03.5-1.61.9
Reaction time number correct1.72.42.71.6-1.5
Reaction time mean minus median8.911.812.0-3.43.5
Reaction time mean minus median AUC6.38.28.5-2.82.9
Reaction time num false alarms1.92.52.6-1.61.6
Reaction time num false alarms AUC2.43.33.3-1.81.8
Reaction time trials correct on left1.72.42.71.6-1.5
Reaction time trials on left1.31.92.21.5-1.3
Reaction time mean0.91.21.2-1.11.1
Reaction time mean AUC0.50.70.7-0.80.8
Median of all reaction times0.00.00.0-0.00.0
Reaction time omissions10.013.614.1-3.83.6
Reaction time false alarm rate2.84.04.1-2.01.9
Reaction time premature initiation rate6.08.19.3-3.02.6
Reaction time premature initiations2.53.54.1-2.01.7
Std. dev. reaction times6.79.59.6-3.13.1
Reaction time trials completed1.31.92.21.5-1.3
Reaction time trials AUC2.13.13.41.8-1.7
Run reversals in cocaine runway, females0.10.10.10.2-0.3
Run reversals in cocaine runway, males1.71.71.9-1.21.4
Latency to leave start box in cocaine runway0.00.00.0-0.10.2
Latency to leave start box in cocaine runway, F1.82.02.1-1.41.4
Latency to leave start box in cocaine runway, M1.91.82.21.5-1.2
Std. dev. time between licks in bursts1.31.61.7-1.31.2
Total sessions with >9 infusions1.51.71.7-1.31.3
Short access day 1 total inactive lever presses1.61.82.0-1.41.3
Short access day 10 total inactive lever presses0.10.10.1-0.20.3
Short access day 1 total infusions0.20.20.2-0.50.5
Short access day 10 total infusions1.92.12.3-1.41.5
Short access total infusions1.11.31.3-1.11.1
Short access day 1 locomotion0.20.20.2-0.50.5
Short access day 10 total locomotion0.10.10.2-0.40.2
Short access total locomotion0.60.60.7-0.80.8
One hour access (0.3 mA shock)0.10.20.3-0.50.2
Compulsive drug intake1.21.21.41.2-1.0
One hour access (shock baseline)0.10.10.2-0.50.1
Social response proportion0.20.20.2-0.40.4
Social responses8.510.911.1-3.33.3
Social time0.10.10.20.2-0.4
Soleus weight0.82.42.61.5-1.6
Bone: stiffness19.831.331.65.6-5.6
Tibialis anterior weight1.55.06.31.9-2.5
Time to tail flick, vehicle, before self-admin0.60.70.8-0.90.7
Time to tail flick, vehicle, after self-admin0.60.60.70.7-0.9
Time to tail flick, test, before self-admin0.10.10.2-0.4-0.2
Time to tail flick, test, after self-admin0.60.60.80.6-0.9
Delta time to tail flick, vehicle, before/after SA0.50.50.50.7-0.7
Delta time to tail flick, test, before/after SA0.10.10.20.5-0.2
Tibia length6.418.119.44.4-4.1
Ambulatory time before self-admin3.94.04.6-2.11.8
Ambulatory time after self-admin2.42.72.9-1.61.7
Bone: tissue strength2.12.02.31.3-1.5
Total heroin consumption1.71.92.31.5-1.3
Bone: trabecular number6.410.010.83.3-3.0
Bone: trabecular spacing2.63.43.4-1.81.9
Bone: trabecular thickness0.00.10.1-0.1-0.3
Bone: trabecular tissue density0.00.00.10.0-0.3
Water consumed over 24 hours0.00.00.00.10.1
Number of responses in last shaping day0.10.10.10.2-0.3