Hub : Genes

Mat2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr10_25113065_25116692 0.6 0.12 9.2e-11 0.01 0.1 0.08 0.07 2.4e-02 1.6e-11 2.0e-09 1.4e-08
2 Liver intron excision ratio chr10_25112547_25112951 0.56 0.13 2.3e-09 0.01 0.09 0.07 0.07 1.2e-02 4.5e-10 1.0e-08 5.9e-08
3 PL mRNA stability Mat2b 0.11 0.06 0.0e+00 0.16 0.17 0.18 0.18 1.5e-17 7.2e-19 9.4e-20 1.4e-19
4 Brain gene expression Mat2b 0.28 0.15 0.0e+00 0.3 0.3 0.29 0.3 7.8e-28 1.2e-27 6.8e-27 5.4e-28
5 Liver gene expression Mat2b 0.16 0.11 7.2e-04 0.01 0.01 0.01 0.01 1.4e-02 4.3e-02 2.7e-02 3.0e-02
6 Adipose mRNA stability Mat2b 0.15 0.1 1.8e-11 0.07 0.08 0.07 0.06 7.8e-08 4.9e-09 5.2e-08 8.9e-08
7 Brain mRNA stability Mat2b 0.32 0.15 0.0e+00 0.38 0.4 0.39 0.4 1.4e-37 3.1e-39 1.8e-38 1.5e-39
8 pVTA gene expression Mat2b 0.14 0.17 7.3e-04 0.06 0.01 0.05 0.07 1.6e-03 1.2e-01 4.0e-03 7.6e-04
9 pVTA mRNA stability Mat2b 0.09 0.09 2.9e-03 0.06 0.06 0.05 0.05 1.4e-03 9.4e-04 3.7e-03 2.3e-03
10 NAcc gene expression Mat2b 0.3 0 0.0e+00 0.33 0.32 0.32 0.32 8.7e-39 5.1e-38 3.7e-38 2.3e-38
11 Adipose intron excision ratio chr10_25116886_25120353 0.04 0.03 2.3e-04 0.02 0.02 0.02 0.02 5.8e-03 2.7e-03 2.9e-03 5.2e-03
12 Liver mRNA stability Mat2b 0.04 0.05 9.9e-03 0.01 0 0 0 3.6e-02 1.7e-01 1.8e-01 8.1e-02
13 OFC mRNA stability Mat2b 0.25 0.19 1.3e-05 0.19 0.21 0.18 0.19 2.8e-05 1.0e-05 3.6e-05 3.2e-05
14 BLA mRNA stability Mat2b 0.11 0.07 1.5e-07 0.13 0.12 0.12 0.12 1.9e-07 4.2e-07 8.3e-07 6.7e-07
15 LHb mRNA stability Mat2b 0.15 0.14 1.1e-03 0.09 0.12 0.09 0.11 3.3e-03 8.9e-04 4.0e-03 1.4e-03
16 NAcc intron excision ratio chr10_25116886_25122643 0.02 0.02 9.6e-04 0.03 0.02 0.03 0.03 4.9e-04 7.9e-04 3.7e-04 4.6e-04
17 BLA gene expression Mat2b 0.34 0.14 5.6e-17 0.28 0.29 0.3 0.3 4.4e-15 5.4e-16 2.4e-16 3.3e-16
18 PL gene expression Mat2b 0.36 0.06 0.0e+00 0.3 0.29 0.3 0.3 7.1e-34 2.2e-32 1.4e-33 2.5e-33
19 IL gene expression Mat2b 0.25 0.18 1.6e-05 0.19 0.2 0.18 0.19 2.9e-05 1.4e-05 4.4e-05 2.8e-05
20 IL mRNA stability Mat2b 0.33 0.2 4.2e-08 0.17 0.32 0.31 0.3 5.6e-05 2.3e-08 3.0e-08 7.1e-08
21 NAcc mRNA stability Mat2b 0.09 0.05 0.0e+00 0.12 0.16 0.14 0.15 9.3e-14 3.9e-18 1.2e-15 4.7e-17
22 NAcc intron excision ratio chr10_25116886_25120353 0.02 0.02 1.7e-03 0.02 0.02 0.02 0.02 1.0e-03 2.0e-03 9.4e-04 1.3e-03
23 Adipose intron excision ratio chr10_25116886_25122643 0.02 0.02 4.8e-03 0.01 0.01 0 0.01 3.3e-02 4.9e-02 1.3e-01 7.1e-02
24 OFC gene expression Mat2b 0.24 0.2 6.6e-05 0.19 0.19 0.21 0.19 2.8e-05 3.2e-05 1.3e-05 3.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Bone: apparent density0.00.10.10.1-0.10.3-0.3-0.2-0.4-0.2-0.3-0.30.30.30.3-0.30.4-0.30.20.20.2-0.3-0.3-0.3-0.20.30.1
Area under the delay curve2.72.98.72.9-3.0-1.61.61.21.81.71.61.5-1.8-1.5-1.41.4-1.61.4-1.6-1.6-1.61.41.51.51.6-1.3-1.7
BMI with tail0.62.19.63.1-3.1-0.71.20.81.71.11.01.1-0.9-1.4-1.51.2-0.91.2-1.2-1.3-1.01.21.21.31.2-1.2-1.2
BMI without tail0.40.88.72.9-3.00.20.1-0.20.90.00.00.10.1-0.4-0.30.20.10.20.0-0.40.10.10.10.2-0.0-0.30.0
Body weight1.04.05.60.2-0.12.4-2.3-1.9-2.0-2.2-2.2-2.02.32.02.0-2.12.2-2.02.11.92.3-2.0-2.0-2.0-2.02.11.8
Weight adjusted by age0.30.30.80.9-0.9-0.40.60.30.40.60.70.3-0.8-0.4-0.50.4-0.80.4-0.3-0.5-0.70.40.40.40.2-0.4-0.3
Bone surface0.20.30.6-0.60.70.6-0.6-0.4-0.8-0.4-0.5-0.60.50.60.7-0.60.6-0.60.70.50.5-0.6-0.6-0.6-0.70.50.6
Bone volume0.61.01.40.8-0.71.2-1.1-1.1-1.0-0.9-1.0-1.11.01.01.1-1.11.0-1.11.00.90.9-1.1-1.1-1.1-1.01.00.9
Breakpoint value in progressive ratio session0.40.55.12.3-2.20.4-0.1-0.2-0.20.10.1-0.2-0.20.20.2-0.3-0.1-0.30.5-0.2-0.1-0.3-0.3-0.3-0.60.40.1
Number of licking bursts0.00.00.10.4-0.40.1-0.2-0.2-0.0-0.2-0.2-0.20.20.10.2-0.20.2-0.20.10.20.2-0.2-0.2-0.1-0.10.0-0.0
Context. condit. distance diff. score0.50.61.2-0.10.11.0-0.7-1.1-0.5-0.6-0.8-0.90.80.70.5-0.70.8-0.70.90.90.5-0.7-0.8-0.8-0.90.60.9
Locomotion velocity, session 10.50.50.60.5-0.5-0.70.70.80.70.80.70.7-0.6-0.7-0.80.7-0.70.7-0.7-0.7-0.80.70.70.70.7-0.8-0.7
Locomotion distance, session 10.30.31.01.0-1.0-0.40.31.00.30.40.60.7-0.5-0.4-0.30.5-0.40.5-0.6-0.8-0.30.50.60.60.6-0.3-0.7
Locomotion velocity, session 20.91.11.31.0-1.0-1.01.01.11.01.01.11.1-1.1-1.0-1.01.0-1.11.0-1.1-1.1-0.91.01.01.01.0-1.1-1.0
Locomotion distance, session 20.50.61.71.3-1.3-0.50.60.80.80.60.80.8-0.5-0.7-0.70.7-0.50.7-0.8-0.9-0.50.80.80.80.9-0.8-0.9
Locomotion velocity, session 31.21.46.52.5-2.5-0.90.81.20.81.01.11.0-1.2-0.8-0.60.8-1.20.8-1.0-1.3-0.90.80.90.91.0-0.7-1.2
Locomotion distance, session 32.42.63.61.4-1.4-1.61.51.91.41.51.71.7-1.8-1.5-1.41.6-1.71.6-1.7-1.8-1.41.61.61.61.7-1.4-1.8
Stereotopy head waving bouts, day 30.30.43.01.7-1.70.4-0.4-0.4-0.3-0.3-0.3-0.30.40.40.5-0.50.4-0.50.30.10.4-0.5-0.5-0.5-0.30.60.3
Stereotopy head waving duration, day 30.50.61.31.2-1.10.7-0.7-0.8-0.5-0.6-0.6-0.80.80.70.8-0.80.8-0.80.70.60.6-0.8-0.8-0.8-0.70.90.8
Locomotion velocity, session 71.31.41.9-0.70.71.3-1.2-1.2-1.1-1.2-1.3-1.21.41.21.1-1.21.4-1.21.31.21.2-1.2-1.2-1.2-1.21.11.1
Locomotion distance, session 70.00.10.1-0.10.10.3-0.3-0.2-0.2-0.2-0.2-0.30.30.20.2-0.20.3-0.20.30.20.2-0.2-0.2-0.2-0.30.10.2
Stereotopy head waving bouts, day 70.70.81.41.1-1.01.0-1.0-0.7-0.8-0.9-0.9-0.81.00.90.9-0.91.0-0.90.90.71.0-0.9-0.9-0.9-0.81.20.7
Stereotopy head waving duration, day 71.01.21.80.1-0.01.2-1.2-1.1-1.0-1.1-1.2-1.11.21.11.1-1.11.2-1.11.21.01.1-1.1-1.1-1.1-1.11.31.1
Locomotion velocity, session 81.21.43.81.9-1.9-0.91.11.11.21.11.21.2-0.9-1.1-1.11.1-0.91.1-1.1-1.3-1.11.11.11.11.1-1.1-1.2
Locomotion distance, session 80.20.30.90.8-0.70.9-0.7-0.5-0.5-0.6-0.5-0.50.70.50.5-0.60.7-0.50.60.40.6-0.5-0.5-0.5-0.60.60.4
Degree of sensitization distance3.23.24.5-1.61.61.7-1.7-2.1-1.5-1.7-1.9-1.92.01.61.6-1.71.9-1.72.02.01.5-1.8-1.8-1.8-2.01.42.1
Degree of sensitization stereotypy1.11.21.90.5-0.41.3-1.3-1.0-1.1-1.2-1.1-1.11.21.11.2-1.11.2-1.11.21.01.2-1.1-1.1-1.1-1.11.41.0
Conditioned locomotion0.10.10.20.1-0.10.4-0.3-0.4-0.2-0.3-0.4-0.30.40.30.3-0.30.4-0.30.20.40.2-0.3-0.3-0.2-0.10.30.2
Cocaine response after cond. corrected0.40.40.7-0.80.80.6-0.8-0.4-0.7-0.7-0.6-0.50.80.60.8-0.60.8-0.60.60.50.7-0.6-0.5-0.6-0.60.70.6
Cocaine response after cond. not corrected0.20.20.5-0.40.40.5-0.6-0.3-0.5-0.6-0.4-0.30.70.50.6-0.40.7-0.40.40.40.6-0.4-0.4-0.4-0.40.50.4
Cocaine response before conditioning0.50.62.01.4-1.4-0.70.70.50.90.60.70.6-0.6-0.7-0.70.6-0.60.6-0.7-0.6-0.60.60.60.60.7-0.7-0.6
Saline control response0.20.31.4-1.21.20.4-0.4-0.4-0.5-0.4-0.5-0.60.30.50.5-0.50.3-0.50.50.60.4-0.5-0.5-0.5-0.60.30.6
Bone: connectivity density0.10.21.0-1.01.0-0.40.20.7-0.00.40.30.4-0.3-0.2-0.20.3-0.20.3-0.3-0.3-0.30.40.40.30.3-0.2-0.5
Bone: cortical apparent density0.70.91.70.9-0.91.0-0.8-1.3-0.7-0.9-1.0-1.00.70.90.8-1.00.7-1.00.90.90.9-1.0-1.0-1.0-0.80.91.0
Bone: cortical area0.71.11.90.5-0.51.4-1.2-1.3-1.0-1.0-1.1-1.21.11.11.0-1.11.2-1.11.01.11.0-1.1-1.1-1.1-1.00.90.9
Bone: cortical porosity0.20.20.5-0.70.70.5-0.4-0.6-0.6-0.5-0.6-0.50.50.50.4-0.40.5-0.40.40.50.5-0.4-0.4-0.4-0.40.50.3
Bone: cortical porosity1.21.31.8-1.31.31.1-1.1-1.2-1.2-1.2-1.2-1.11.11.11.0-1.11.1-1.11.11.21.1-1.1-1.1-1.1-1.11.01.0
Bone: cortical thickness0.91.42.71.2-1.11.5-1.2-1.6-0.9-1.1-1.2-1.31.31.11.0-1.21.3-1.21.11.21.1-1.2-1.2-1.1-1.01.01.1
Bone: cortical thickness0.20.21.00.7-0.70.5-0.2-1.00.1-0.3-0.5-0.50.40.20.0-0.30.4-0.30.40.50.2-0.3-0.3-0.3-0.4-0.10.5
Bone: cortical tissue density0.50.71.40.9-0.80.8-0.7-1.2-0.6-0.8-0.9-0.90.60.80.7-0.90.6-0.90.80.80.8-0.9-0.9-0.9-0.80.80.9
Condit. Reinf. active minus inactive responses1.01.14.32.1-2.1-0.81.00.61.20.91.00.8-1.0-1.0-1.00.9-1.10.9-0.9-0.9-0.90.80.80.90.9-0.8-0.7
Condit. Reinf. active-inactive response ratio0.10.10.60.8-0.8-0.30.40.00.50.30.30.2-0.4-0.3-0.30.3-0.50.3-0.2-0.3-0.30.30.20.20.2-0.2-0.1
Condit. Reinf. active responses0.20.22.21.5-1.5-0.10.2-0.10.40.20.20.1-0.3-0.2-0.20.1-0.30.1-0.2-0.1-0.20.10.10.10.2-0.1-0.2
Condit. Reinf. inactive responses0.60.71.0-0.10.11.0-0.9-1.0-0.8-0.8-0.9-0.90.90.90.9-0.90.9-0.90.80.90.9-0.9-0.9-0.9-0.70.70.7
Incentive salience index mean0.30.41.41.2-1.2-0.50.50.40.60.60.60.5-0.6-0.5-0.50.5-0.70.5-0.6-0.5-0.50.50.50.50.6-0.4-0.5
Condit. Reinf. lever presses0.20.30.5-0.40.40.6-0.6-0.3-0.7-0.5-0.5-0.50.50.60.6-0.60.5-0.50.50.50.6-0.5-0.5-0.5-0.50.60.4
Condit. Reinf. active minus inactive responses0.81.01.91.4-1.31.2-1.1-1.0-0.9-0.9-0.9-0.91.01.01.1-1.11.0-1.00.70.90.9-1.0-1.0-0.9-0.71.20.8
Condit. Reinf. active-inactive response ratio0.10.11.61.3-1.20.3-0.1-0.20.00.1-0.0-0.10.10.10.1-0.10.1-0.1-0.10.0-0.2-0.1-0.0-0.00.10.2-0.0
Condit. Reinf. active responses2.33.24.40.4-0.32.0-2.1-1.8-1.9-1.9-1.8-1.81.92.02.1-2.01.9-1.91.71.71.9-1.9-1.9-1.8-1.62.01.6
Condit. Reinf. inactive responses3.64.55.9-1.11.22.1-2.3-2.0-2.3-2.3-2.2-2.12.12.32.4-2.22.1-2.22.12.02.4-2.2-2.2-2.2-2.12.21.9
Condit. Reinf. lever presses0.10.21.01.0-1.0-0.10.20.30.30.30.30.3-0.3-0.3-0.20.2-0.30.3-0.3-0.3-0.20.30.30.30.3-0.2-0.4
Condit. Reinf. lever reinforcers received2.63.64.60.1-0.02.1-2.1-2.0-2.0-2.0-1.9-1.92.02.02.1-2.02.0-2.01.91.92.0-2.0-2.0-1.9-1.92.01.8
Conditioned reinforcement - actives2.52.58.5-2.92.91.3-1.5-1.1-1.7-1.3-1.3-1.41.21.51.6-1.41.3-1.41.61.41.2-1.4-1.4-1.4-1.61.51.3
Conditioned reinforcement - inactives0.60.61.6-0.40.60.6-0.8-0.5-1.2-0.6-0.7-0.80.51.01.0-0.90.5-0.90.90.70.5-0.9-0.9-0.9-0.91.30.9
Conditioned locomotion1.11.37.2-2.72.60.8-0.9-1.0-1.0-0.8-0.9-1.00.60.91.0-0.91.0-0.90.81.20.5-0.9-0.9-0.9-0.81.00.9
Patch foraging indifference point 0 sec2.13.34.5-0.30.42.0-2.0-1.6-2.1-1.9-1.8-1.81.62.02.1-2.01.5-2.02.01.61.9-2.0-1.9-1.9-2.02.11.7
Patch foraging indifference point AUC0.20.20.40.6-0.60.5-0.6-0.1-0.5-0.5-0.2-0.30.40.50.6-0.40.3-0.40.30.20.5-0.4-0.4-0.4-0.30.70.2
Delay disc. indifference point, 0s delay1.31.412.73.6-3.50.6-0.5-1.2-0.0-0.4-0.5-0.70.40.60.7-0.80.4-0.80.30.50.6-0.7-0.7-0.7-0.30.50.6
Delay disc. indifference point, 16s delay4.14.26.22.5-2.5-1.91.91.72.12.01.92.0-2.1-2.0-1.92.0-2.02.0-2.1-1.9-2.02.02.02.02.1-1.9-2.2
Delay disc. indifference point, 2s delay0.50.52.21.4-1.5-0.80.80.11.00.80.60.5-0.8-0.7-0.60.5-0.80.5-0.7-0.5-0.70.50.50.50.6-0.6-0.3
Delay disc. indifference point, 24s delay3.43.35.20.7-0.8-2.01.82.01.71.71.82.0-1.8-1.8-1.81.9-1.71.9-1.9-1.8-1.61.92.02.02.0-1.8-2.3
Delay disc. indifference point, 4s delay0.40.54.32.1-2.1-0.40.4-0.10.60.50.40.2-0.6-0.3-0.20.2-0.50.2-0.3-0.3-0.40.20.10.20.20.0-0.2
Delay disc. indifference point, 8s delay0.90.91.51.0-1.0-1.00.91.10.81.01.01.0-1.0-0.8-0.80.9-1.00.9-0.9-1.0-0.90.91.01.00.9-0.6-1.2
Indifference point function ln k0.00.00.1-0.20.2-0.10.20.00.20.20.10.1-0.3-0.2-0.40.2-0.20.20.0-0.1-0.30.20.20.2-0.1-0.3-0.1
Indifference point function log k0.00.00.1-0.20.2-0.10.20.00.20.20.10.1-0.3-0.2-0.40.2-0.20.20.0-0.1-0.30.20.20.2-0.1-0.3-0.1
Patch foraging total patch changes 0 sec2.33.75.10.3-0.22.2-2.1-1.8-2.2-2.0-1.8-1.91.72.12.3-2.11.6-2.12.11.72.0-2.1-2.1-2.1-2.12.21.8
Patch foraging total patch changes 12 sec0.50.71.30.5-0.40.8-0.9-0.6-0.8-1.0-0.8-0.70.80.91.0-0.90.7-0.90.90.61.1-0.9-0.9-0.9-0.91.00.8
Patch foraging total patch changes 18 sec0.81.01.60.5-0.51.1-1.1-1.0-1.0-1.1-1.0-1.00.91.11.2-1.10.9-1.11.00.91.1-1.1-1.1-1.1-1.01.21.0
Patch foraging total patch changes 24 sec0.20.20.40.6-0.60.6-0.5-0.3-0.4-0.6-0.4-0.40.40.40.5-0.50.3-0.40.50.30.6-0.4-0.4-0.4-0.60.50.2
Patch foraging total patch changes 6 sec1.42.13.4-1.51.51.4-1.7-0.9-1.8-1.6-1.4-1.31.41.61.8-1.51.3-1.51.31.31.7-1.4-1.4-1.4-1.21.61.0
Patch foraging time to switch 0 sec0.50.81.4-1.11.0-1.21.00.60.90.90.60.7-0.8-0.8-1.00.9-0.80.8-0.9-0.5-1.00.80.80.81.0-1.0-0.6
Patch foraging water rate 0 sec0.81.35.92.4-2.4-0.60.90.81.10.81.11.0-0.9-1.0-0.90.9-1.00.9-0.9-1.2-0.70.90.91.00.9-1.1-1.0
Patch foraging water rate 12 sec1.11.64.02.0-2.0-0.81.11.01.41.01.21.2-1.0-1.3-1.11.2-1.01.2-1.1-1.3-1.01.21.21.21.1-1.6-1.4
Patch foraging water rate 18 sec0.20.22.41.5-1.50.3-0.3-0.10.0-0.3-0.1-0.10.20.20.3-0.20.2-0.20.1-0.10.4-0.2-0.2-0.2-0.1-0.0-0.1
Patch foraging water rate 24 sec0.50.75.02.2-2.20.8-0.6-0.5-0.3-0.6-0.3-0.50.50.50.6-0.60.5-0.60.50.20.7-0.6-0.6-0.6-0.60.40.4
Patch foraging water rate 6 sec1.62.48.62.9-2.9-0.91.21.21.61.21.41.4-1.3-1.4-1.31.3-1.31.4-1.4-1.6-1.21.41.41.41.3-1.4-1.6
Seeking ratio, delayed vs. immediate footshock0.00.00.10.3-0.30.1-0.1-0.1-0.1-0.10.1-0.10.10.10.1-0.10.1-0.1-0.00.10.0-0.1-0.1-0.10.1-0.20.1
Distance traveled before self-admin0.10.10.7-0.20.20.2-0.3-0.80.2-0.4-0.5-0.40.60.10.1-0.20.6-0.20.40.50.4-0.3-0.3-0.3-0.4-0.10.6
Distance traveled after self-admin1.21.32.8-1.21.31.1-1.1-1.1-1.0-1.3-1.1-1.11.21.01.0-1.01.3-1.01.51.11.2-1.0-1.1-1.1-1.70.80.9
Extensor digitorum longus weight0.31.23.21.8-1.71.1-1.1-1.2-0.9-0.9-0.9-0.91.01.11.2-1.11.0-1.10.70.91.0-1.0-1.0-1.0-0.61.30.8
Bone: elastic displacement0.10.10.60.8-0.80.10.1-0.10.20.10.10.0-0.0-0.2-0.20.1-0.00.10.0-0.1-0.10.10.10.1-0.1-0.3-0.0
Bone: elastic work0.70.91.10.8-0.8-0.81.01.00.90.91.01.0-0.9-1.0-1.01.0-0.91.0-0.9-1.0-0.91.01.01.00.9-1.1-0.9
Bone: endosteal estimation0.10.20.6-0.30.3-0.60.50.80.20.50.60.5-0.6-0.4-0.30.4-0.50.5-0.4-0.6-0.50.40.40.40.4-0.5-0.5
Bone: endosteal perimeter0.10.10.40.5-0.4-0.20.20.60.10.30.40.4-0.3-0.2-0.00.2-0.30.2-0.3-0.4-0.20.20.30.20.3-0.1-0.5
Epididymis fat weight0.20.55.12.3-2.1-0.00.00.7-0.10.40.60.4-0.3-0.10.10.1-0.40.2-0.4-0.7-0.20.20.20.20.3-0.1-0.6
Delta time in closed arm before/after self-admin0.50.55.82.4-2.30.5-0.2-0.50.30.00.0-0.20.10.00.1-0.10.2-0.10.30.00.0-0.1-0.1-0.1-0.40.20.0
Delta time in open arm before/after self-admin1.11.07.6-2.72.70.2-0.6-0.4-1.0-0.8-0.9-0.60.80.80.8-0.70.8-0.70.40.80.9-0.7-0.6-0.6-0.20.40.6
Diff in mean of infusions in LGA sessions0.50.66.22.5-2.40.2-0.1-0.6-0.1-0.0-0.1-0.4-0.10.30.3-0.4-0.2-0.40.30.2-0.1-0.4-0.4-0.4-0.30.40.1
Delay discount exponential model param2.82.97.4-2.72.71.6-1.6-1.3-1.8-1.7-1.7-1.61.81.51.4-1.51.7-1.51.61.61.6-1.5-1.5-1.5-1.61.31.7
Extinction: sum of active levers before priming1.71.62.20.1-0.1-1.31.41.51.11.41.51.3-1.4-1.3-1.31.3-1.41.3-1.1-1.4-1.51.31.31.31.0-1.4-1.4
Active lever presses in extinction session 61.00.92.11.4-1.5-0.80.90.80.91.00.90.9-1.0-0.9-0.90.9-0.90.9-0.9-0.9-0.90.90.90.90.9-0.8-1.1
Bone: final force0.20.30.40.1-0.1-0.40.40.60.30.60.60.5-0.5-0.5-0.50.5-0.40.6-0.5-0.5-0.60.60.60.60.5-0.4-0.6
Bone: final moment0.20.30.50.3-0.3-0.40.40.70.40.70.60.6-0.5-0.5-0.60.6-0.40.6-0.6-0.6-0.70.60.60.60.6-0.5-0.7
Food consumed during 24 hour testing period0.20.20.80.9-0.9-0.50.30.40.40.40.40.4-0.6-0.3-0.10.3-0.60.3-0.6-0.4-0.30.30.30.40.7-0.2-0.5
Glucose0.00.00.3-0.50.50.1-0.1-0.10.0-0.1-0.1-0.00.4-0.00.00.00.40.0-0.10.10.00.00.00.00.1-0.20.0
Heart weight0.20.32.31.5-1.40.1-0.00.8-0.60.20.40.3-0.30.20.20.0-0.30.00.1-0.6-0.10.00.10.0-0.20.6-0.3
Delay discount hyperbolic model param2.32.56.9-2.62.61.5-1.5-1.1-1.6-1.6-1.5-1.41.71.41.3-1.31.6-1.31.51.41.5-1.3-1.3-1.4-1.41.11.5
Intermittent access intake day 1-15 change2.01.922.3-4.74.70.0-0.20.2-0.8-0.5-0.3-0.20.30.30.1-0.10.4-0.00.40.60.3-0.1-0.1-0.1-0.4-0.10.2
Intermittent access intake escalation0.60.65.7-2.42.40.3-0.3-0.4-0.5-0.5-0.4-0.40.40.30.1-0.20.4-0.20.40.60.3-0.2-0.2-0.3-0.4-0.00.3
Intermittent access intake escalation 22.62.616.0-4.04.01.1-1.2-0.9-1.5-1.4-1.3-1.21.21.11.0-1.01.3-1.01.41.41.2-1.0-1.0-1.1-1.41.01.1
Intermitt. access day 1 inactive lever presses0.50.61.1-0.50.4-1.00.81.00.60.80.80.9-0.8-0.7-0.60.8-0.80.8-0.5-0.8-0.80.80.80.80.5-0.7-0.7
Intermitt. access day 15 inactive lever presses1.11.27.42.7-2.7-0.80.90.01.31.00.80.5-1.2-0.8-0.80.6-1.00.6-0.4-0.7-1.20.60.50.60.3-0.7-0.3
Intermitt. access escalation Index4.23.78.8-2.93.01.5-1.8-1.5-2.1-1.9-1.8-1.71.91.91.9-1.82.1-1.81.71.91.8-1.8-1.8-1.8-1.61.51.9
Intermittent access day 1 total infusions0.30.41.3-0.60.70.3-0.6-0.0-1.1-0.3-0.4-0.40.20.81.0-0.70.1-0.70.70.30.3-0.7-0.6-0.7-0.71.00.6
Intermittent access day 15 total infusions0.60.72.0-1.31.40.5-0.8-0.4-1.3-0.5-0.6-0.70.51.01.0-0.80.4-0.80.80.70.5-0.8-0.8-0.8-0.80.90.6
Intermittent access terminal intake (last 3 days)0.50.64.3-2.02.10.2-0.60.1-1.2-0.3-0.3-0.30.20.70.7-0.50.2-0.50.60.40.2-0.5-0.4-0.5-0.60.70.2
Intermittent access total infusions0.50.54.4-2.02.1-0.0-0.40.4-1.1-0.1-0.1-0.10.00.60.6-0.4-0.0-0.30.40.20.1-0.3-0.2-0.3-0.40.70.0
Intermittent access day 1 locomotion2.32.43.9-0.50.61.4-1.7-1.3-2.0-1.4-1.5-1.61.31.82.0-1.71.4-1.71.71.41.3-1.7-1.7-1.7-1.71.91.6
Intermittent access day 15 total locomotion0.60.65.5-2.32.30.2-0.4-0.2-0.8-0.3-0.4-0.40.20.50.5-0.40.3-0.40.70.50.2-0.4-0.4-0.5-0.80.50.4
Intermittent access total locomotion0.50.64.6-2.12.20.1-0.5-0.1-0.8-0.3-0.3-0.40.10.50.6-0.40.2-0.40.60.40.2-0.4-0.4-0.4-0.60.60.3
Intermittent access standard deviation1.81.921.8-4.74.6-0.20.00.7-0.90.0-0.10.0-0.20.2-0.20.1-0.10.10.30.2-0.10.10.10.0-0.4-0.0-0.0
Left kidney weight0.20.51.41.2-1.10.6-0.8-0.1-1.0-0.5-0.4-0.40.40.80.9-0.70.4-0.70.50.20.6-0.7-0.6-0.6-0.51.20.3
Right kidney weight0.10.22.01.4-1.3-0.0-0.10.7-0.50.20.20.2-0.20.20.3-0.1-0.3-0.1-0.2-0.4-0.1-0.00.0-0.00.30.6-0.4
Cocaine induced anxiety0.70.87.42.7-2.70.7-0.3-1.00.2-0.4-0.4-0.60.50.30.1-0.50.6-0.50.40.40.4-0.5-0.6-0.5-0.40.30.8
Post-drug Anxiety1.11.214.73.8-3.80.30.0-0.50.50.10.1-0.1-0.0-0.1-0.1-0.10.0-0.1-0.0-0.1-0.0-0.2-0.2-0.10.00.10.1
Baseline Anxiety5.15.47.91.1-1.2-2.42.32.72.12.42.52.5-2.4-2.3-2.22.4-2.52.4-2.4-2.5-2.42.42.52.42.4-2.2-2.8
Tail length2.06.27.6-1.41.52.4-2.6-2.4-2.5-2.6-2.5-2.52.52.52.7-2.52.5-2.52.72.42.6-2.6-2.6-2.6-2.82.52.6
Length with tail3.713.618.1-3.23.33.6-3.9-3.1-4.3-3.8-3.7-3.63.73.93.9-3.73.7-3.73.83.63.8-3.7-3.7-3.7-3.83.93.4
Length without tail3.78.112.0-3.03.12.8-3.0-2.4-3.5-2.9-2.9-2.72.83.12.9-2.82.8-2.82.62.82.8-2.8-2.7-2.8-2.62.92.5
Times rat made contact with spout1.01.21.9-0.1-0.0-1.21.20.81.21.31.01.0-1.1-1.1-1.11.1-1.11.1-1.2-0.9-1.41.11.11.11.3-1.3-1.0
Lifetime Intake0.10.10.5-0.40.4-0.50.10.7-0.40.50.40.3-0.50.10.10.1-0.60.1-0.2-0.4-0.50.20.20.20.20.2-0.4
Liver weight, left1.52.43.30.5-0.41.8-1.8-1.4-1.6-1.6-1.4-1.41.61.61.8-1.61.6-1.61.61.31.8-1.6-1.6-1.6-1.71.61.3
Liver weight, right0.20.40.8-0.20.30.9-0.8-0.5-0.6-0.7-0.6-0.60.70.60.7-0.60.7-0.60.80.50.8-0.6-0.6-0.6-0.80.50.6
Locomotor activity7.111.213.90.6-0.43.7-3.6-3.4-3.3-3.6-3.5-3.53.43.53.5-3.63.4-3.63.33.23.7-3.5-3.5-3.5-3.33.73.4
Locomotor testing distance11.419.022.5-0.81.04.7-4.6-4.7-4.2-4.6-4.6-4.64.54.54.5-4.64.5-4.64.54.54.6-4.6-4.6-4.5-4.44.54.5
Locomotor testing rearing8.513.116.80.8-0.64.1-3.9-3.8-3.6-3.8-3.7-3.83.73.83.8-3.83.6-3.83.63.53.9-3.8-3.8-3.8-3.64.13.5
Locomotion in novel chamber0.10.10.30.1-0.1-0.10.40.20.20.40.20.1-0.5-0.3-0.40.2-0.50.20.2-0.3-0.40.20.20.1-0.3-0.2-0.1
Locomotion in novel chamber post-restriction0.30.30.7-0.20.2-0.40.70.80.40.60.70.5-0.6-0.6-0.70.7-0.70.7-0.0-0.7-0.70.60.60.5-0.2-0.5-0.4
Fecal boli incidents, locomotor time 10.20.20.6-0.30.4-0.40.20.8-0.20.30.70.5-0.4-0.1-0.10.3-0.50.3-0.5-0.5-0.30.30.40.40.5-0.1-0.8
Change in fecal boli incidents, locomotor task1.21.12.0-0.40.4-1.01.30.61.41.10.90.9-0.9-1.3-1.41.2-0.91.2-0.9-0.8-1.21.21.11.10.8-1.4-1.0
Time >=10cm from walls, locomotor time 10.70.76.82.6-2.6-0.30.50.00.80.40.30.3-0.4-0.4-0.30.3-0.40.3-0.4-0.5-0.20.30.30.30.5-0.8-0.4
Bouts of movement, locomotor time 10.60.75.8-2.42.4-0.40.40.8-0.00.40.30.5-0.4-0.4-0.40.5-0.30.5-0.4-0.3-0.30.50.50.50.4-0.6-0.6
Total resting periods, locomotor time 10.80.94.1-2.02.0-0.90.81.20.30.80.70.9-0.8-0.7-0.60.9-0.80.9-0.7-0.7-0.70.90.90.80.7-0.9-0.9
Rest time, locomotor task time 10.10.10.3-0.60.6-0.40.10.3-0.10.30.30.2-0.2-0.10.20.1-0.30.1-0.3-0.2-0.30.10.10.10.3-0.3-0.3
Distance moved, locomotor task time 10.80.91.9-0.90.91.2-0.8-1.4-0.4-1.0-1.1-1.11.20.60.3-0.71.2-0.70.81.20.8-0.8-0.8-0.8-0.80.61.2
Vertical activity count, locomotor time 10.30.33.1-1.81.70.40.1-0.50.3-0.2-0.3-0.20.4-0.3-0.60.20.50.20.30.40.00.20.10.1-0.4-0.40.3
Time >=10cm from walls, locomotor time 20.20.20.90.9-0.90.3-0.1-0.90.3-0.2-0.4-0.40.40.1-0.1-0.20.3-0.2-0.00.60.3-0.2-0.2-0.20.1-0.20.2
Bouts of movement, locomotor time 20.60.61.2-0.10.20.6-0.8-0.5-1.0-0.7-0.7-0.60.70.91.1-0.90.8-0.90.90.61.1-0.8-0.8-0.8-0.80.70.6
Total resting periods, locomotor time 20.30.30.9-0.30.30.4-0.5-0.1-0.8-0.5-0.4-0.30.50.70.9-0.60.5-0.60.70.30.8-0.6-0.5-0.5-0.70.40.3
Rest time, locomotor task time 22.42.77.0-0.20.2-2.11.52.70.91.81.82.0-1.7-1.4-1.01.6-1.81.6-1.5-2.1-1.61.61.71.71.5-1.6-1.9
Distance moved, locomotor task time 21.31.54.4-1.00.91.6-1.0-2.1-0.5-1.3-1.5-1.61.40.90.5-1.01.4-1.11.01.61.1-1.1-1.2-1.2-1.00.81.6
Vertical activity count, locomotor time 20.50.62.7-1.61.50.7-0.2-1.30.1-0.7-0.7-0.80.70.1-0.3-0.30.8-0.30.51.00.4-0.3-0.4-0.4-0.5-0.20.9
Light reinforcement 11.01.92.4-0.80.81.4-1.5-1.3-1.4-1.5-1.4-1.41.41.41.4-1.41.5-1.41.41.41.5-1.4-1.4-1.4-1.41.41.3
Light reinforcement 21.21.72.70.6-0.61.6-1.3-1.6-0.9-1.4-1.4-1.41.61.21.0-1.31.6-1.31.31.41.3-1.3-1.3-1.3-1.31.11.1
Bone: marrow area0.10.30.8-0.40.4-0.70.50.90.30.60.60.6-0.6-0.5-0.40.5-0.60.5-0.5-0.6-0.50.50.50.50.4-0.5-0.6
Bone: maximum diameter0.00.10.80.9-0.90.1-0.0-0.10.10.10.1-0.0-0.0-0.00.0-0.00.00.0-0.1-0.1-0.10.00.00.00.1-0.2-0.2
Bone: maximum force0.00.10.10.2-0.2-0.10.20.20.10.30.20.2-0.2-0.2-0.20.2-0.10.2-0.2-0.2-0.30.20.20.20.2-0.3-0.3
Bone: maximum moment0.10.10.20.4-0.4-0.10.20.30.20.40.30.3-0.2-0.3-0.30.3-0.20.3-0.3-0.3-0.40.30.30.30.3-0.3-0.4
Mean time between licks in bursts1.31.83.40.6-0.7-1.21.31.11.51.41.31.4-1.0-1.4-1.41.4-1.01.4-1.7-1.1-1.41.41.51.51.8-1.4-1.6
Mean num. licks in bursts0.30.40.8-0.70.7-0.70.70.40.50.70.50.5-0.6-0.6-0.60.6-0.60.6-0.6-0.4-0.90.60.60.50.6-0.6-0.3
Cd content in liver11.312.416.30.9-0.74.0-3.7-4.0-3.2-3.6-3.5-3.83.53.63.6-3.83.5-3.83.83.53.5-3.8-3.8-3.8-3.83.73.5
Co content in liver0.80.91.40.1-0.11.1-0.9-1.2-0.8-0.9-0.9-1.10.80.90.9-1.00.8-1.01.11.00.9-1.0-1.0-1.0-1.11.01.2
Cu content in liver0.60.71.20.2-0.2-1.00.91.10.60.90.90.9-1.0-0.8-0.70.8-1.00.9-0.9-1.0-0.90.90.90.90.9-0.6-1.1
Fe content in liver1.92.33.41.8-1.8-1.41.51.21.51.61.51.4-1.6-1.4-1.41.4-1.61.4-1.6-1.5-1.61.41.41.41.6-1.4-1.5
K content in liver0.00.00.3-0.20.2-0.20.00.5-0.00.10.10.3-0.0-0.1-0.00.2-0.00.2-0.2-0.30.00.20.20.20.20.3-0.3
Mg content in liver0.80.81.2-0.10.1-1.00.91.10.80.90.91.0-0.8-0.9-0.91.0-0.81.0-1.0-0.9-0.91.01.01.01.0-0.8-0.8
Mn content in liver0.60.75.1-2.32.20.5-0.6-0.4-0.7-0.7-0.6-0.50.70.60.5-0.50.7-0.50.70.70.6-0.5-0.5-0.5-0.70.50.5
Na content in liver3.13.34.40.1-0.2-2.01.92.01.91.81.82.0-1.7-1.9-2.02.0-1.72.0-1.9-1.8-1.72.02.02.01.9-2.1-1.8
Rb content in liver0.91.11.7-0.30.31.1-1.0-1.3-0.9-1.1-1.1-1.21.11.01.0-1.11.1-1.11.11.21.0-1.1-1.1-1.1-1.10.91.3
Se content in liver0.91.11.6-0.50.4-1.11.01.30.81.11.11.1-1.0-1.0-1.01.1-1.01.1-1.1-1.0-1.11.11.11.11.0-0.9-1.1
Sr content in liver0.80.81.2-0.20.31.0-0.9-0.8-1.0-0.9-0.8-0.90.80.90.9-0.90.8-0.90.90.80.9-0.9-0.9-0.9-1.01.10.9
Zn content in liver0.10.10.20.3-0.3-0.30.20.10.20.30.20.2-0.3-0.1-0.10.2-0.30.2-0.4-0.2-0.40.20.20.20.50.0-0.2
Bone: minimum diameter0.30.62.81.7-1.7-0.60.60.60.70.70.60.6-0.7-0.6-0.50.6-0.60.6-0.8-0.7-0.60.60.60.60.9-0.5-0.9
Time in familiar zone, hab. session 10.30.32.11.4-1.4-0.10.40.10.50.30.30.2-0.3-0.4-0.40.3-0.30.3-0.2-0.4-0.40.30.30.30.1-0.4-0.4
Time in novel zone, hab. session 11.11.01.40.1-0.1-1.11.01.21.01.11.11.1-1.0-1.0-0.91.1-1.01.0-1.1-1.1-1.01.11.11.11.1-1.0-1.0
Total zone transitions, hab. session 10.40.53.41.9-1.8-0.50.30.70.50.30.40.6-0.6-0.4-0.30.4-0.60.4-0.6-0.7-0.20.40.50.50.7-0.2-0.6
Total locomotion distance, hab. session 10.30.54.82.2-2.10.4-0.4-0.1-0.2-0.3-0.2-0.10.20.30.4-0.40.2-0.40.2-0.00.5-0.3-0.3-0.3-0.10.50.0
Locomotion velocity, hab. session 10.60.82.81.7-1.60.9-0.9-0.7-0.7-0.9-0.8-0.70.70.80.9-0.90.8-0.90.60.61.0-0.9-0.8-0.8-0.61.00.7
Time in familiar zone, hab. session 22.62.63.4-1.41.41.6-1.7-1.5-1.7-1.7-1.6-1.61.81.61.6-1.61.8-1.61.61.71.7-1.6-1.6-1.6-1.61.61.6
Time in novel zone, hab. session 21.91.92.61.6-1.6-1.21.41.11.41.41.31.3-1.6-1.4-1.31.3-1.51.3-1.3-1.4-1.41.31.31.31.2-1.3-1.3
Total zone transitions, hab. session 22.43.17.22.7-2.7-1.51.51.81.51.61.81.8-1.7-1.5-1.41.5-1.71.6-1.9-1.9-1.51.61.71.71.9-1.3-2.0
Total locomotion distance, hab. session 20.60.86.92.6-2.6-0.20.30.60.40.40.60.6-0.5-0.3-0.20.3-0.50.3-0.6-0.7-0.30.40.40.40.7-0.0-0.7
Locomotion velocity, hab. session 20.81.07.52.7-2.7-0.50.50.80.60.60.80.8-0.7-0.5-0.40.5-0.70.5-0.9-0.9-0.50.60.60.60.9-0.2-0.9
Novel to familiar place preference ratio0.10.10.70.9-0.80.00.0-0.10.20.1-0.1-0.0-0.1-0.1-0.00.0-0.00.00.1-0.1-0.10.0-0.00.0-0.1-0.00.2
Novelty place preference0.20.21.11.1-1.00.4-0.3-0.4-0.1-0.3-0.4-0.30.20.20.3-0.30.3-0.30.40.20.2-0.3-0.3-0.3-0.40.30.4
Time in novel zone, NPP test0.20.21.61.3-1.20.3-0.2-0.30.0-0.2-0.3-0.20.10.10.3-0.20.2-0.20.30.10.2-0.3-0.3-0.2-0.30.30.3
Total zone transitions, NPP test1.21.85.92.4-2.4-1.01.01.31.11.11.21.3-1.1-1.1-1.01.1-1.11.1-1.4-1.4-0.91.21.21.21.4-0.9-1.5
Total locomotion distance, NPP test0.40.66.02.5-2.40.6-0.5-0.1-0.2-0.3-0.2-0.10.30.30.4-0.40.3-0.40.1-0.00.5-0.3-0.3-0.2-0.10.60.1
Locomotion velocity, NPP test0.40.66.22.5-2.40.6-0.5-0.2-0.2-0.4-0.2-0.20.40.40.4-0.40.4-0.40.20.00.5-0.4-0.3-0.3-0.10.70.1
Intraocular pressure1.42.08.12.8-2.8-1.01.21.11.41.21.41.2-1.5-1.2-1.21.1-1.41.1-1.0-1.4-1.21.11.11.10.9-1.2-1.3
Delta distance traveled before/after self-admin0.10.10.6-0.70.80.2-0.20.3-0.6-0.2-0.0-0.10.00.30.3-0.20.1-0.20.60.00.2-0.2-0.2-0.3-0.70.4-0.1
Delta ambulatory time before/after self-admin0.00.00.20.3-0.20.10.00.4-0.30.10.30.1-0.30.10.1-0.0-0.2-0.00.3-0.3-0.1-0.0-0.0-0.1-0.50.1-0.3
Parametrial fat weight0.40.86.12.5-2.5-0.50.50.70.70.50.70.7-0.6-0.5-0.40.4-0.60.4-0.6-0.9-0.30.50.50.50.7-0.4-0.8
Pavlov. Cond. lever latency0.20.20.70.8-0.8-0.50.40.40.50.40.40.4-0.5-0.4-0.40.4-0.40.4-0.4-0.5-0.40.40.40.40.4-0.5-0.4
Pavlov. Cond. magazine entry latency1.01.23.4-1.91.91.0-1.1-0.9-1.1-1.1-1.1-0.91.11.11.0-1.01.1-1.00.91.11.1-1.0-0.9-0.9-0.81.10.8
Pavlov. Cond. change in total contacts2.02.13.1-1.71.81.6-1.5-1.3-1.5-1.4-1.6-1.31.71.41.3-1.31.7-1.31.31.51.4-1.3-1.3-1.3-1.31.51.2
Pavlov. Cond. index score0.50.62.6-1.61.60.7-0.7-0.6-0.8-0.7-0.8-0.60.80.70.7-0.60.7-0.60.60.80.7-0.6-0.6-0.6-0.60.70.5
Pavlov. Cond. latency score0.60.83.7-1.91.90.7-0.8-0.6-0.9-0.7-0.8-0.70.80.70.7-0.70.8-0.70.70.90.7-0.7-0.6-0.7-0.70.80.6
Pavlov. Cond. lever contacts1.21.53.1-1.71.81.2-1.2-1.1-1.2-1.1-1.2-1.21.31.11.0-1.11.2-1.11.11.31.1-1.1-1.1-1.1-1.11.11.0
Pavlov. Cond. magazine entry number0.20.30.50.7-0.7-0.60.60.50.60.50.60.5-0.6-0.5-0.50.5-0.60.5-0.5-0.6-0.60.50.50.50.4-0.6-0.4
Pavlov. Cond. intertrial magazine entries0.50.51.00.7-0.70.9-0.7-1.0-0.5-0.7-0.7-0.90.80.60.6-0.70.8-0.70.80.70.6-0.8-0.8-0.8-0.80.70.7
Pavlov. Cond. lever-magazine prob. diff.0.80.92.4-1.51.50.9-1.0-0.8-1.0-0.9-1.0-0.90.90.90.9-0.90.9-0.90.81.00.9-0.8-0.8-0.8-0.81.00.7
Pavlov. Cond. response bias0.40.50.8-0.90.90.8-0.8-0.7-0.8-0.7-0.8-0.70.80.70.7-0.70.8-0.70.60.80.7-0.7-0.7-0.7-0.60.80.6
Pavlov. Cond. lever latency0.30.40.60.2-0.20.6-0.6-0.8-0.6-0.6-0.6-0.70.60.70.6-0.70.6-0.70.70.60.6-0.7-0.7-0.7-0.70.70.8
Pavlov. Cond. magazine entry latency1.61.93.50.7-0.7-1.41.21.91.11.31.41.6-1.5-1.3-1.11.4-1.51.4-1.5-1.6-1.21.41.51.41.5-1.1-1.6
Pavlov. Cond. change in total contacts0.10.20.70.8-0.80.4-0.5-0.1-0.4-0.4-0.3-0.20.20.40.6-0.40.2-0.40.20.10.5-0.4-0.3-0.3-0.20.50.2
Pavlov. Cond. index score0.70.91.50.6-0.6-0.90.91.20.80.91.01.1-1.0-0.9-0.81.0-1.01.0-1.1-1.1-0.81.01.01.01.1-0.8-1.1
Pavlov. Cond. latency score0.60.71.40.5-0.5-0.80.71.20.70.80.91.0-0.9-0.8-0.70.9-0.90.9-1.0-1.0-0.70.90.90.91.0-0.7-1.0
Pavlov. Cond. lever contacts0.81.11.40.4-0.5-1.01.01.21.11.01.11.1-1.0-1.1-1.01.1-1.01.1-1.1-1.1-1.01.11.11.11.1-1.2-1.1
Pavlov. Cond. magazine entry number0.00.00.2-0.20.20.1-0.0-0.50.1-0.1-0.1-0.30.20.0-0.0-0.10.2-0.10.20.3-0.0-0.1-0.2-0.2-0.3-0.00.2
Pavlov. Cond. intertrial magazine entries0.30.41.01.0-0.90.7-0.5-1.0-0.3-0.5-0.6-0.70.50.50.4-0.60.5-0.60.60.60.5-0.6-0.6-0.6-0.70.50.6
Pavlov. Cond. lever-magazine prob. diff.0.71.01.70.6-0.7-0.90.91.30.80.91.01.1-1.0-0.9-0.81.0-1.01.0-1.1-1.1-0.81.01.01.01.1-0.8-1.1
Pavlov. Cond. response bias0.60.81.20.6-0.7-0.90.81.10.80.80.91.0-0.9-0.9-0.80.9-0.90.9-1.0-1.0-0.80.90.90.91.0-0.8-1.0
Time in closed arm before self-admin0.40.44.1-2.02.0-0.1-0.20.5-0.7-0.1-0.10.00.10.30.3-0.10.0-0.10.20.00.1-0.1-0.1-0.2-0.10.30.1
Time in closed arm after self-admin0.90.97.82.8-2.70.8-0.6-0.6-0.3-0.4-0.3-0.50.50.60.8-0.60.4-0.60.70.30.5-0.6-0.6-0.5-0.70.50.3
Time in open arm before self-admin2.12.33.81.0-1.0-1.31.71.02.01.61.51.4-1.5-1.8-1.91.7-1.51.7-1.4-1.3-1.71.61.61.61.2-1.7-1.4
Time in open arm after self-admin0.90.95.0-2.22.20.5-0.6-0.9-0.8-0.9-0.9-0.80.70.80.6-0.80.8-0.80.61.00.8-0.8-0.8-0.8-0.60.50.8
Bone: periosteal estimation0.10.10.20.1-0.10.4-0.4-0.3-0.5-0.3-0.3-0.40.30.40.4-0.40.4-0.40.40.30.3-0.4-0.4-0.4-0.40.30.2
Bone: periosteal perimeter0.10.11.11.1-1.00.3-0.3-0.0-0.2-0.1-0.0-0.10.20.20.3-0.20.2-0.20.1-0.00.2-0.2-0.2-0.2-0.10.2-0.1
Bone: post-yield work1.21.72.3-0.60.61.4-1.3-1.5-1.3-1.2-1.4-1.41.31.31.3-1.41.4-1.41.41.41.2-1.4-1.4-1.4-1.41.11.4
Progressive ratio test 1 active lever presses0.40.51.3-1.11.10.2-0.70.0-1.1-0.5-0.4-0.40.50.81.0-0.70.3-0.70.70.30.4-0.6-0.6-0.6-0.70.90.5
Progressive ratio test 1 breakpoint0.60.72.1-1.41.50.3-0.8-0.1-1.2-0.6-0.6-0.50.70.91.1-0.80.5-0.80.80.50.6-0.7-0.7-0.7-0.71.00.6
Progressive ratio test 1 inactive lever presses1.01.11.90.3-0.3-1.31.01.40.71.21.31.2-1.3-0.9-0.71.0-1.31.0-1.0-1.2-1.41.01.01.01.0-0.3-1.1
Progressive ratio test 2 active lever presses1.61.72.80.8-0.71.3-1.4-1.3-1.4-1.1-1.1-1.31.11.41.4-1.40.9-1.41.61.11.0-1.4-1.4-1.4-1.71.71.1
Progressive ratio test 2 breakpoint1.61.72.90.10.01.3-1.4-1.3-1.5-1.2-1.2-1.41.21.51.5-1.51.0-1.41.71.21.1-1.4-1.4-1.4-1.71.71.2
Progressive ratio test 2 inactive lever presses0.60.71.4-0.60.70.6-0.8-0.7-1.0-0.6-0.7-0.80.60.91.0-0.90.6-0.91.10.70.5-0.9-0.9-0.9-1.20.90.8
Incentive Sensitization - Responses1.91.93.61.9-1.81.5-1.3-1.6-1.1-1.2-1.2-1.41.11.31.3-1.41.0-1.41.51.21.1-1.4-1.4-1.4-1.61.61.2
Incentive Sensitization - Breakpoint2.02.03.41.8-1.71.6-1.3-1.7-1.1-1.2-1.2-1.51.11.31.2-1.51.1-1.41.61.21.1-1.5-1.5-1.4-1.71.51.2
Sum of active levers in priming session hrs 5-60.90.88.52.9-2.9-0.30.4-0.10.70.40.30.3-0.3-0.3-0.20.2-0.30.2-0.4-0.3-0.40.20.30.30.5-0.5-0.5
Progressive ratio0.70.81.71.3-1.20.8-0.8-0.7-0.9-0.7-0.6-0.80.71.01.1-1.00.7-1.00.50.60.9-1.0-1.0-1.0-0.41.10.8
Food seeking constrained by brief footshock0.50.74.52.1-2.1-0.20.30.40.90.40.50.6-0.3-0.6-0.40.5-0.30.5-0.6-0.6-0.40.60.60.70.6-0.2-1.0
Seeking ratio, punishment vs. effort0.91.11.7-0.80.7-0.91.01.01.20.90.91.1-0.8-1.2-1.21.3-0.81.3-0.9-0.9-1.11.31.31.30.8-1.1-1.3
Retroperitoneal fat weight0.31.11.91.4-1.4-0.90.91.31.01.01.11.1-0.9-1.1-0.81.1-0.91.1-1.0-1.3-0.91.11.01.00.9-1.1-1.2
Reaction time number correct9.213.215.6-2.72.73.8-4.0-3.5-3.9-3.8-3.7-3.73.73.83.9-3.83.7-3.73.63.73.7-3.7-3.7-3.7-3.53.63.4
Reaction time mean minus median4.05.48.2-0.70.6-2.72.42.91.92.42.42.5-2.4-2.3-2.32.4-2.52.5-2.4-2.4-2.42.52.52.42.4-2.0-2.3
Reaction time mean minus median AUC2.83.66.7-1.21.1-2.31.92.61.41.91.92.1-2.0-1.8-1.72.0-2.12.0-1.9-2.1-1.92.02.02.02.0-1.5-1.9
Reaction time num false alarms3.44.712.1-3.43.51.8-2.0-1.5-2.2-2.2-2.0-1.91.81.92.0-1.91.8-1.92.31.92.3-1.9-1.9-2.0-2.51.82.2
Reaction time num false alarms AUC3.34.511.7-3.43.41.8-1.9-1.4-2.2-2.1-1.9-1.91.81.92.0-1.91.8-1.92.31.92.2-1.9-1.9-2.0-2.41.72.2
Reaction time trials correct on left9.213.215.6-2.72.73.8-4.0-3.5-3.9-3.8-3.7-3.73.73.83.9-3.83.7-3.73.63.73.7-3.7-3.7-3.7-3.53.63.4
Reaction time trials on left9.513.615.9-2.93.03.8-4.0-3.6-3.9-3.8-3.8-3.73.83.83.9-3.83.8-3.83.63.73.7-3.7-3.7-3.7-3.53.63.4
Reaction time mean6.18.511.60.8-0.9-3.33.03.42.63.13.13.1-3.0-2.9-2.83.0-3.13.0-3.0-3.2-3.23.03.03.02.9-2.7-3.0
Reaction time mean AUC6.18.211.90.6-0.6-3.32.93.42.53.13.13.1-3.0-2.9-2.73.0-3.13.0-2.9-3.1-3.13.03.02.92.8-2.6-2.9
Median of all reaction times4.46.08.21.1-1.1-2.82.52.92.22.62.72.6-2.6-2.5-2.32.5-2.62.5-2.4-2.7-2.72.52.52.52.4-2.3-2.5
Reaction time omissions2.12.923.4-4.84.80.6-1.0-0.3-1.5-1.0-1.1-0.91.11.01.0-0.81.1-0.81.21.10.9-0.9-0.9-1.0-1.20.81.2
Reaction time false alarm rate0.20.31.0-1.01.0-0.60.60.70.40.40.50.5-0.7-0.5-0.50.5-0.70.5-0.1-0.5-0.20.50.40.4-0.1-0.7-0.0
Reaction time premature initiation rate0.10.11.41.2-1.20.2-0.1-0.10.20.0-0.0-0.00.00.0-0.1-0.10.2-0.1-0.20.00.1-0.0-0.00.00.20.0-0.2
Reaction time premature initiations2.33.24.2-0.40.42.0-2.1-1.9-1.8-1.9-1.9-1.91.91.91.9-1.92.0-1.91.61.91.9-1.9-1.9-1.8-1.51.81.5
Std. dev. reaction times2.63.66.1-1.41.3-2.31.92.51.42.01.92.1-1.9-1.8-1.82.0-2.02.0-1.9-1.9-2.02.02.01.91.9-1.7-1.8
Reaction time trials completed9.513.615.9-2.93.03.8-4.0-3.6-3.9-3.8-3.8-3.73.83.83.9-3.83.8-3.83.63.73.7-3.7-3.7-3.7-3.53.63.4
Reaction time trials AUC9.613.816.0-3.03.03.9-4.0-3.6-3.9-3.8-3.8-3.83.83.93.9-3.83.8-3.83.73.83.7-3.8-3.7-3.7-3.63.63.5
Run reversals in cocaine runway, females1.61.62.81.5-1.41.4-1.3-1.7-0.9-1.2-1.4-1.31.21.21.2-1.31.2-1.31.21.21.0-1.3-1.2-1.2-1.01.31.0
Run reversals in cocaine runway, males2.01.99.93.1-3.1-0.90.91.01.21.01.11.1-1.2-1.0-0.91.0-1.21.0-1.3-1.2-0.81.01.11.11.4-0.8-1.4
Latency to leave start box in cocaine runway0.00.00.1-0.10.00.1-0.2-0.20.1-0.3-0.1-0.10.30.00.1-0.10.3-0.10.20.20.3-0.1-0.1-0.1-0.10.30.3
Latency to leave start box in cocaine runway, F0.30.30.6-0.10.0-0.60.60.80.60.50.70.6-0.3-0.6-0.70.7-0.40.6-0.4-0.6-0.50.60.60.60.3-0.4-0.5
Latency to leave start box in cocaine runway, M0.30.21.71.3-1.30.3-0.2-0.70.3-0.4-0.3-0.30.30.10.3-0.30.3-0.30.30.20.5-0.3-0.3-0.3-0.20.30.5
Std. dev. time between licks in bursts0.10.10.3-0.00.00.4-0.4-0.6-0.2-0.3-0.3-0.40.40.30.3-0.40.4-0.40.10.50.2-0.3-0.3-0.3-0.10.30.3
Total sessions with >9 infusions1.61.83.92.0-2.0-1.31.11.21.11.51.41.2-1.4-1.1-0.91.1-1.51.1-1.4-1.3-1.61.11.21.21.4-1.0-1.4
Short access day 1 total inactive lever presses1.41.54.1-2.02.00.9-1.2-0.8-1.6-1.0-1.0-1.10.91.31.4-1.11.0-1.11.31.20.9-1.1-1.1-1.2-1.31.40.9
Short access day 10 total inactive lever presses0.20.20.50.4-0.4-0.30.6-0.00.70.40.30.2-0.6-0.6-0.70.4-0.40.4-0.1-0.2-0.50.40.30.30.0-0.4-0.1
Short access day 1 total infusions1.11.22.21.3-1.20.9-1.1-1.0-1.1-0.8-0.9-1.00.81.21.5-1.30.8-1.30.90.90.9-1.2-1.2-1.2-0.91.11.1
Short access day 10 total infusions0.20.20.7-0.70.7-0.50.10.8-0.50.50.40.4-0.50.10.20.1-0.50.1-0.3-0.4-0.40.20.20.20.40.3-0.5
Short access total infusions0.20.20.50.7-0.6-0.60.20.7-0.20.60.50.4-0.6-0.00.10.1-0.70.1-0.3-0.5-0.60.20.20.20.40.2-0.4
Short access day 1 locomotion0.20.21.8-1.41.4-0.10.10.2-0.10.10.10.1-0.2-0.1-0.10.2-0.10.20.2-0.0-0.20.20.10.1-0.3-0.0-0.2
Short access day 10 total locomotion0.30.33.82.0-1.90.10.0-0.50.30.20.0-0.2-0.30.0-0.1-0.1-0.0-0.10.20.1-0.3-0.1-0.1-0.1-0.2-0.1-0.0
Short access total locomotion0.10.21.41.2-1.10.1-0.2-0.3-0.20.0-0.1-0.2-0.00.30.4-0.30.1-0.30.20.1-0.1-0.2-0.2-0.2-0.10.40.0
One hour access (0.3 mA shock)0.10.21.4-1.11.20.0-0.20.2-0.70.10.1-0.1-0.10.30.2-0.2-0.2-0.10.20.1-0.1-0.1-0.1-0.2-0.20.5-0.1
Compulsive drug intake0.50.55.92.4-2.40.10.0-0.00.30.20.20.1-0.1-0.10.10.0-0.10.0-0.5-0.3-0.20.10.10.10.50.1-0.3
One hour access (shock baseline)1.01.28.0-2.82.80.5-0.8-0.4-1.3-0.6-0.7-0.70.60.90.7-0.70.5-0.71.00.80.6-0.7-0.7-0.8-1.00.90.7
Social response proportion0.40.42.61.6-1.60.6-0.4-0.8-0.1-0.1-0.4-0.50.30.40.4-0.50.4-0.50.30.40.1-0.5-0.5-0.5-0.30.40.5
Social responses0.40.64.82.2-2.20.7-0.5-0.7-0.1-0.2-0.3-0.50.20.40.7-0.50.2-0.50.30.20.4-0.5-0.5-0.5-0.30.50.4
Social time0.00.10.2-0.50.4-0.30.10.5-0.00.20.30.3-0.3-0.10.00.2-0.40.2-0.2-0.4-0.20.20.20.20.20.1-0.2
Soleus weight0.10.21.61.3-1.20.1-0.2-0.30.0-0.1-0.1-0.10.20.10.2-0.10.2-0.10.00.00.1-0.1-0.1-0.10.00.30.1
Bone: stiffness0.00.10.1-0.20.20.2-0.2-0.4-0.2-0.2-0.3-0.30.20.20.1-0.20.3-0.20.20.30.1-0.2-0.2-0.2-0.20.10.2
Tibialis anterior weight1.13.64.8-0.90.91.9-2.0-2.1-1.9-1.9-2.0-2.02.02.02.0-2.02.0-2.01.82.01.9-2.0-2.0-2.0-1.72.22.0
Time to tail flick, vehicle, before self-admin1.61.62.2-0.10.1-1.51.41.51.11.31.31.4-1.2-1.2-1.21.3-1.21.3-1.4-1.3-1.41.31.31.31.4-1.4-1.4
Time to tail flick, vehicle, after self-admin0.00.00.3-0.60.6-0.1-0.10.2-0.1-0.0-0.00.10.40.10.1-0.00.20.0-0.10.00.00.00.10.10.2-0.2-0.1
Time to tail flick, test, before self-admin2.82.85.32.3-2.3-1.41.61.51.71.71.71.6-1.7-1.6-1.51.5-1.61.5-1.5-1.7-1.71.61.61.61.5-1.5-1.8
Time to tail flick, test, after self-admin5.65.841.16.4-6.4-1.21.80.72.41.71.91.4-1.9-1.7-1.81.4-1.91.4-1.4-1.8-1.81.41.41.51.2-1.6-1.5
Delta time to tail flick, vehicle, before/after SA2.22.23.1-1.71.81.5-1.6-1.4-1.5-1.5-1.6-1.41.61.41.3-1.41.5-1.41.41.51.5-1.4-1.3-1.3-1.41.41.3
Delta time to tail flick, test, before/after SA0.60.55.02.2-2.2-0.20.4-0.00.60.30.40.2-0.5-0.4-0.40.3-0.50.3-0.3-0.4-0.30.20.20.20.2-0.3-0.1
Tibia length0.00.10.20.2-0.2-0.20.30.20.30.20.20.3-0.2-0.3-0.40.3-0.20.3-0.3-0.2-0.20.30.30.30.4-0.2-0.4
Ambulatory time before self-admin0.10.11.0-1.00.9-0.30.1-0.20.4-0.1-0.20.10.2-0.3-0.30.20.20.2-0.20.20.10.20.20.20.2-0.40.0
Ambulatory time after self-admin0.10.10.4-0.40.40.2-0.3-0.2-0.2-0.4-0.2-0.20.30.20.1-0.20.4-0.20.50.30.4-0.2-0.2-0.2-0.6-0.00.0
Bone: tissue strength1.11.12.00.3-0.3-1.11.01.40.71.11.11.2-1.0-1.0-1.01.1-1.11.1-1.1-1.2-1.11.11.11.11.1-0.7-1.2
Total heroin consumption0.91.09.43.1-3.0-0.30.60.20.80.60.50.5-0.7-0.6-0.70.4-0.80.4-0.3-0.7-0.60.40.40.50.3-0.3-0.7
Bone: trabecular number0.10.10.4-0.60.6-0.40.30.40.10.30.20.3-0.2-0.2-0.30.3-0.20.3-0.4-0.2-0.30.30.40.30.4-0.3-0.5
Bone: trabecular spacing0.20.30.60.8-0.80.5-0.5-0.4-0.4-0.6-0.5-0.50.40.50.5-0.60.4-0.60.50.40.6-0.6-0.5-0.5-0.50.60.5
Bone: trabecular thickness1.01.21.5-0.80.91.2-1.2-1.2-1.2-1.0-1.2-1.21.21.11.2-1.11.2-1.11.11.21.0-1.1-1.1-1.1-1.10.91.0
Bone: trabecular tissue density0.60.94.02.0-2.0-0.70.80.70.90.70.80.8-0.9-0.8-0.70.7-0.90.7-0.7-0.9-0.60.70.70.70.7-0.7-0.8
Water consumed over 24 hours0.10.10.7-0.80.80.1-0.2-0.2-0.3-0.2-0.3-0.20.10.20.2-0.20.1-0.20.20.30.2-0.2-0.2-0.2-0.20.30.3
Number of responses in last shaping day0.91.01.7-1.11.0-1.30.91.00.70.90.81.0-0.9-0.9-0.91.0-1.01.0-1.0-0.8-1.01.01.01.01.0-0.9-1.1