Mast4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	XM_039103960.1	0.04	0.04	9.5e-04	0.01	0.01	0.01	0.01	1.8e-02	1.3e-02	3.3e-02	2.5e-02
2	Brain	intron excision ratio	chr2_33964820_33969144	0.04	0.04	1.4e-03	0.04	0.03	0.03	0.03	2.3e-04	1.0e-03	7.6e-04	3.5e-04
3	Eye	gene expression	Mast4	0.55	0.22	6.9e-04	0.05	0.08	0.07	0.05	5.5e-02	2.6e-02	3.3e-02	6.3e-02
4	Brain	mRNA stability	Mast4	0.16	0.11	9.4e-16	0.16	0.17	0.16	0.16	6.7e-15	2.0e-15	5.5e-15	3.9e-15
5	BLA	mRNA stability	Mast4	0.09	0.08	1.1e-03	0.04	0.02	0.02	0.01	5.5e-03	3.1e-02	1.8e-02	7.5e-02
6	Liver	mRNA stability	Mast4	0.05	0.04	2.7e-06	0.04	0.03	0.04	0.03	3.8e-05	9.9e-05	7.4e-05	2.3e-04
7	PL	mRNA stability	Mast4	0.04	0.04	4.9e-04	0.03	0.03	0.03	0.03	1.7e-04	8.1e-04	6.8e-04	3.2e-04
8	Adipose	gene expression	Mast4	0.18	0.14	4.3e-10	0.08	0.07	0.07	0.08	2.2e-09	5.1e-08	1.2e-08	1.9e-09
9	Adipose	isoform ratio	XM_039103960.1	0.02	0.02	5.4e-03	0.01	0	0.01	0	4.3e-02	8.2e-02	6.0e-02	7.7e-02
10	Adipose	intron excision ratio	chr2_34212463_34293688	0.04	0.03	2.0e-05	0.04	0.02	0.03	0.01	5.6e-05	6.0e-03	5.7e-04	5.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10
Bone: apparent density	1.2	2.0	2.5	1.3	1.3	-1.3	-1.4	-1.4	-1.4	-1.3	-1.5	-1.5	1.6
Area under the delay curve	0.5	0.5	1.1	-0.5	-0.1	0.5	0.6	1.0	0.9	1.0	0.6	0.6	-0.6
BMI with tail	2.2	7.2	8.3	2.8	2.9	-2.8	-2.8	-2.6	-2.6	-2.6	-2.6	-2.5	2.7
BMI without tail	0.5	1.1	1.6	1.0	1.2	-1.0	-1.0	-1.0	-0.9	-1.0	-1.0	-1.0	1.1
Body weight	0.9	4.0	4.8	-2.1	-2.2	2.1	1.9	1.9	1.9	1.9	2.0	2.0	-1.8
Weight adjusted by age	1.1	1.3	1.9	-1.0	-0.8	1.0	1.2	0.9	1.4	0.9	1.4	1.4	-1.4
Bone surface	0.6	1.0	1.5	0.8	0.6	-0.8	-1.0	-1.1	-1.1	-1.1	-1.1	-1.1	1.2
Bone volume	0.9	1.5	2.1	1.0	0.8	-1.0	-1.1	-1.3	-1.3	-1.3	-1.4	-1.4	1.5
Breakpoint value in progressive ratio session	2.3	2.5	4.4	1.8	2.1	-1.7	-1.6	-1.6	-1.3	-1.6	-1.4	-1.3	1.3
Number of licking bursts	3.5	4.1	5.5	2.1	2.3	-2.0	-2.0	-2.0	-1.9	-2.0	-1.9	-1.9	1.9
Context. condit. distance diff. score	0.8	1.0	1.1	-1.0	-0.8	1.0	0.9	1.1	1.0	1.0	1.0	1.0	-1.0
Locomotion velocity, session 1	0.4	0.4	0.6	-0.6	-0.7	0.7	0.7	0.5	0.6	0.5	0.6	0.6	-0.7
Locomotion distance, session 1	0.4	0.5	0.7	-0.7	-0.7	0.6	0.6	0.7	0.8	0.7	0.8	0.8	-0.8
Locomotion velocity, session 2	3.1	3.6	4.7	-2.0	-2.2	2.0	1.9	1.9	1.7	1.9	1.8	1.8	-1.7
Locomotion distance, session 2	0.1	0.2	0.4	-0.5	-0.6	0.5	0.4	0.4	0.4	0.4	0.4	0.4	-0.4
Locomotion velocity, session 3	3.3	3.9	4.4	-2.1	-1.9	2.1	2.1	2.0	1.8	2.0	1.8	1.9	-2.1
Locomotion distance, session 3	4.7	5.1	5.8	-2.4	-2.0	2.4	2.4	2.1	2.3	2.1	2.3	2.3	-2.4
Stereotopy head waving bouts, day 3	0.4	0.5	0.8	-0.8	-0.7	0.8	0.8	0.9	0.5	0.9	0.5	0.5	-0.7
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.2	-0.1	0.2	0.2	0.1	-0.1	0.1	-0.1	-0.1	-0.1
Locomotion velocity, session 7	0.8	0.9	1.2	-0.8	-0.4	0.9	1.1	0.9	1.1	0.9	1.1	1.1	-1.1
Locomotion distance, session 7	0.8	1.0	1.2	-0.9	-0.6	0.9	1.0	1.1	1.1	1.1	1.1	1.1	-0.9
Stereotopy head waving bouts, day 7	0.5	0.5	0.8	0.5	0.3	-0.5	-0.7	-0.9	-0.9	-0.9	-0.9	-0.9	0.7
Stereotopy head waving duration, day 7	0.1	0.1	0.2	-0.0	-0.2	0.0	-0.1	-0.4	-0.4	-0.4	-0.3	-0.3	0.1
Locomotion velocity, session 8	2.4	2.9	3.2	-1.8	-1.6	1.8	1.8	1.6	1.7	1.6	1.7	1.7	-1.7
Locomotion distance, session 8	2.0	2.9	3.1	-1.8	-1.7	1.7	1.6	1.8	1.7	1.7	1.7	1.7	-1.7
Degree of sensitization distance	0.8	0.8	1.2	1.1	1.0	-1.1	-1.0	-0.7	-0.8	-0.7	-0.9	-0.9	1.0
Degree of sensitization stereotypy	0.7	0.7	1.1	0.6	0.5	-0.6	-0.8	-1.1	-1.0	-1.1	-0.9	-0.9	0.9
Conditioned locomotion	0.2	0.2	0.4	0.2	0.4	-0.1	-0.1	-0.4	-0.6	-0.5	-0.5	-0.5	0.4
Cocaine response after cond. corrected	2.5	2.8	3.6	-1.6	-1.2	1.6	1.7	1.9	1.7	1.9	1.7	1.7	-1.8
Cocaine response after cond. not corrected	3.1	3.5	5.0	-1.7	-1.3	1.7	1.9	2.2	1.9	2.1	1.8	1.8	-1.9
Cocaine response before conditioning	0.1	0.1	0.2	-0.3	-0.4	0.3	0.2	0.4	0.2	0.3	0.1	0.1	-0.0
Saline control response	0.3	0.5	0.7	-0.8	-0.9	0.8	0.7	0.6	0.5	0.6	0.6	0.6	-0.6
Bone: connectivity density	0.1	0.2	0.3	0.4	0.4	-0.4	-0.5	-0.3	-0.3	-0.2	-0.4	-0.4	0.6
Bone: cortical apparent density	0.3	0.4	0.6	-0.6	-0.8	0.5	0.5	0.8	0.6	0.7	0.5	0.5	-0.4
Bone: cortical area	0.1	0.2	0.5	-0.4	-0.7	0.4	0.3	0.4	0.2	0.4	0.3	0.3	-0.3
Bone: cortical porosity	0.7	0.8	1.2	0.9	0.6	-0.9	-0.9	-1.1	-0.9	-1.1	-0.9	-0.9	0.9
Bone: cortical porosity	0.7	0.7	1.1	0.9	0.6	-0.9	-0.9	-1.0	-0.8	-1.0	-0.8	-0.8	0.9
Bone: cortical thickness	0.5	0.8	1.0	-0.8	-1.0	0.8	0.7	0.9	0.9	1.0	0.9	0.9	-0.9
Bone: cortical thickness	1.4	1.6	2.1	-1.1	-1.2	1.0	1.0	1.4	1.3	1.4	1.3	1.3	-1.4
Bone: cortical tissue density	0.3	0.4	0.7	-0.6	-0.8	0.6	0.5	0.8	0.6	0.8	0.5	0.5	-0.5
Condit. Reinf. active minus inactive responses	1.7	1.9	2.4	1.2	1.1	-1.2	-1.4	-1.6	-1.4	-1.6	-1.4	-1.4	1.5
Condit. Reinf. active-inactive response ratio	2.5	2.7	3.3	1.4	1.3	-1.4	-1.6	-1.8	-1.7	-1.8	-1.7	-1.7	1.8
Condit. Reinf. active responses	0.2	0.2	0.3	0.3	0.4	-0.3	-0.4	-0.6	-0.4	-0.6	-0.5	-0.5	0.5
Condit. Reinf. inactive responses	1.7	2.0	2.5	-1.4	-1.3	1.4	1.6	1.4	1.4	1.4	1.4	1.4	-1.4
Incentive salience index mean	1.4	1.8	2.3	1.2	1.2	-1.2	-1.3	-1.5	-1.3	-1.5	-1.3	-1.3	1.4
Condit. Reinf. lever presses	0.4	0.5	0.9	0.7	1.0	-0.7	-0.7	-0.7	-0.6	-0.7	-0.6	-0.6	0.7
Condit. Reinf. active minus inactive responses	2.5	3.1	3.4	-1.8	-1.8	1.8	1.7	1.7	1.7	1.7	1.7	1.7	-1.8
Condit. Reinf. active-inactive response ratio	1.9	2.0	2.3	-1.5	-1.4	1.5	1.4	1.3	1.4	1.3	1.4	1.4	-1.5
Condit. Reinf. active responses	0.7	0.9	1.0	-1.0	-1.0	1.0	0.9	0.9	0.9	0.9	1.0	1.0	-1.0
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.1	0.0	0.0	0.0	0.0	0.0	0.0
Condit. Reinf. lever presses	1.1	1.6	1.8	-1.2	-1.2	1.1	1.0	1.3	1.3	1.3	1.3	1.3	-1.3
Condit. Reinf. lever reinforcers received	1.0	1.3	1.5	-1.2	-1.2	1.2	1.1	1.1	1.1	1.1	1.2	1.2	-1.2
Conditioned reinforcement - actives	0.8	0.8	1.8	-1.1	-1.3	1.1	0.9	0.7	0.7	0.7	0.7	0.7	-0.7
Conditioned reinforcement - inactives	0.4	0.4	0.5	-0.7	-0.5	0.7	0.7	0.5	0.6	0.7	0.6	0.6	-0.6
Conditioned locomotion	0.4	0.5	0.6	-0.7	-0.6	0.7	0.7	0.6	0.7	0.6	0.7	0.7	-0.7
Patch foraging indifference point 0 sec	2.8	4.5	6.9	-2.4	-2.6	2.3	2.1	1.9	2.1	1.9	2.0	2.0	-1.8
Patch foraging indifference point AUC	1.1	1.3	2.3	1.2	1.5	-1.2	-1.1	-1.1	-1.0	-1.0	-1.0	-1.0	1.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.5	-0.1	0.3	0.0	0.2	0.7	0.4	0.7	0.4	0.4	-0.4
Delay disc. indifference point, 16s delay	0.4	0.4	0.5	-0.6	-0.0	0.6	0.7	0.6	0.7	0.6	0.6	0.6	-0.6
Delay disc. indifference point, 2s delay	0.5	0.6	0.8	-0.6	-0.6	0.6	0.7	0.9	0.8	0.8	0.8	0.8	-0.8
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.3	0.1	0.3	0.4	0.2	0.4	0.2	0.4	0.4	-0.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.8	-0.4	-0.1	0.4	0.5	0.8	0.7	0.9	0.5	0.5	-0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.1	0.3	-0.1	0.0	0.6	0.3	0.6	0.1	0.1	-0.1
Indifference point function ln k	2.3	3.2	6.6	-2.0	-2.6	2.0	1.8	1.6	1.5	1.6	1.5	1.5	-1.5
Indifference point function log k	2.3	3.2	6.6	-2.0	-2.6	2.0	1.8	1.6	1.5	1.6	1.5	1.5	-1.5
Patch foraging total patch changes 0 sec	3.6	5.8	8.4	-2.7	-2.9	2.6	2.4	2.2	2.3	2.2	2.3	2.3	-2.1
Patch foraging total patch changes 12 sec	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3	-0.3	-0.2	-0.3	-0.2	-0.2	0.4
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.0	0.3	-0.1	-0.2	-0.2	0.0	-0.1	-0.1	-0.1	0.2
Patch foraging total patch changes 24 sec	0.3	0.4	0.6	-0.7	-0.7	0.7	0.5	0.5	0.6	0.6	0.6	0.6	-0.4
Patch foraging total patch changes 6 sec	0.8	1.2	1.4	-1.1	-1.0	1.1	1.1	0.9	1.2	1.0	1.2	1.2	-1.0
Patch foraging time to switch 0 sec	5.0	7.7	9.1	3.0	2.8	-3.0	-2.9	-2.7	-2.7	-2.7	-2.7	-2.7	2.6
Patch foraging water rate 0 sec	4.1	6.5	7.7	-2.8	-2.6	2.8	2.6	2.4	2.5	2.3	2.5	2.5	-2.5
Patch foraging water rate 12 sec	4.4	6.7	8.4	-2.9	-2.8	2.9	2.8	2.5	2.4	2.4	2.4	2.4	-2.4
Patch foraging water rate 18 sec	5.0	6.7	7.6	-2.8	-2.7	2.8	2.7	2.5	2.5	2.5	2.5	2.5	-2.5
Patch foraging water rate 24 sec	2.8	3.9	4.9	-2.2	-2.2	2.2	2.2	1.9	1.8	1.8	1.8	1.8	-1.8
Patch foraging water rate 6 sec	12.2	17.9	19.5	-4.4	-4.2	4.4	4.3	4.3	4.2	4.1	4.2	4.2	-4.1
Seeking ratio, delayed vs. immediate footshock	1.6	1.8	2.2	1.3	1.2	-1.3	-1.3	-1.5	-1.4	-1.3	-1.4	-1.4	1.4
Distance traveled before self-admin	2.4	2.5	3.1	-1.5	-1.8	1.5	1.5	1.7	1.5	1.7	1.5	1.5	-1.5
Distance traveled after self-admin	1.7	1.9	2.7	-1.3	-1.7	1.3	1.3	1.5	1.3	1.5	1.3	1.3	-1.3
Extensor digitorum longus weight	3.4	13.5	15.1	3.8	3.7	-3.7	-3.8	-3.9	-3.6	-3.9	-3.4	-3.4	3.6
Bone: elastic displacement	0.7	0.8	1.6	1.0	1.3	-1.0	-0.9	-0.8	-0.9	-0.8	-0.8	-0.8	0.7
Bone: elastic work	0.6	0.8	1.0	0.9	1.0	-1.0	-0.9	-0.8	-1.0	-0.7	-0.8	-0.8	0.8
Bone: endosteal estimation	0.0	0.0	0.1	-0.2	-0.1	0.2	0.2	-0.2	-0.4	-0.2	-0.2	-0.2	0.2
Bone: endosteal perimeter	0.3	0.5	1.0	0.6	0.5	-0.6	-0.6	-0.8	-1.0	-0.8	-0.8	-0.8	0.7
Epididymis fat weight	0.0	0.0	0.1	-0.1	0.1	0.1	-0.0	0.3	0.2	0.3	0.1	0.1	-0.0
Delta time in closed arm before/after self-admin	8.7	8.5	9.7	2.8	2.2	-2.8	-2.9	-3.0	-3.1	-3.0	-3.1	-3.1	3.1
Delta time in open arm before/after self-admin	0.4	0.4	0.6	-0.3	0.2	0.3	0.6	0.6	0.8	0.6	0.8	0.8	-0.8
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	0.2	0.3	-0.2	-0.0	-0.1	0.3	-0.1	0.3	0.3	-0.3
Delay discount exponential model param	0.5	0.6	1.1	0.6	0.2	-0.6	-0.7	-1.1	-0.9	-1.1	-0.7	-0.7	0.7
Extinction: sum of active levers before priming	1.2	1.2	2.5	1.3	1.6	-1.2	-1.1	-0.9	-1.0	-0.9	-1.0	-1.0	1.0
Active lever presses in extinction session 6	0.7	0.7	1.9	1.1	1.4	-1.0	-0.8	-0.7	-0.5	-0.7	-0.5	-0.5	0.5
Bone: final force	0.1	0.2	0.6	-0.5	-0.8	0.5	0.4	0.4	0.3	0.4	0.4	0.4	-0.4
Bone: final moment	0.2	0.4	0.9	-0.7	-0.9	0.7	0.6	0.5	0.4	0.5	0.6	0.6	-0.5
Food consumed during 24 hour testing period	0.9	1.0	1.3	-1.1	-1.2	1.0	0.9	1.1	1.0	1.2	0.9	0.9	-0.9
Glucose	0.0	0.0	0.1	0.3	0.3	-0.2	-0.1	-0.2	-0.1	-0.2	-0.1	-0.1	0.1
Heart weight	1.0	1.4	1.7	1.0	0.8	-1.0	-1.2	-1.2	-1.2	-1.3	-1.2	-1.2	1.2
Delay discount hyperbolic model param	0.7	0.7	1.4	0.7	0.3	-0.6	-0.8	-1.2	-1.0	-1.2	-0.8	-0.8	0.8
Intermittent access intake day 1-15 change	0.2	0.2	0.3	-0.5	-0.5	0.5	0.5	0.4	0.5	0.5	0.5	0.5	-0.5
Intermittent access intake escalation	0.6	0.6	0.7	-0.8	-0.7	0.8	0.8	0.7	0.8	0.8	0.8	0.8	-0.8
Intermittent access intake escalation 2	0.0	0.0	0.0	-0.1	0.0	0.1	0.1	0.1	0.1	0.2	0.1	0.1	-0.1
Intermitt. access day 1 inactive lever presses	2.5	2.6	2.7	1.6	1.6	-1.6	-1.6	-1.6	-1.6	-1.6	-1.6	-1.6	1.6
Intermitt. access day 15 inactive lever presses	1.6	1.7	3.1	1.5	1.8	-1.5	-1.3	-1.2	-1.2	-1.2	-1.2	-1.2	1.2
Intermitt. access escalation Index	0.2	0.2	0.3	-0.4	-0.5	0.4	0.4	0.5	0.4	0.4	0.4	0.4	-0.4
Intermittent access day 1 total infusions	0.6	0.7	0.8	-0.9	-0.8	0.9	0.9	0.8	0.8	0.8	0.8	0.8	-0.8
Intermittent access day 15 total infusions	2.0	2.2	2.5	-1.6	-1.5	1.6	1.5	1.4	1.5	1.4	1.5	1.5	-1.5
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.0	-1.0	-0.9	1.0	1.0	0.9	1.0	0.9	1.0	1.0	-0.9
Intermittent access total infusions	1.9	2.2	2.4	-1.6	-1.5	1.6	1.5	1.4	1.4	1.4	1.4	1.4	-1.4
Intermittent access day 1 locomotion	2.3	2.4	2.7	-1.6	-1.6	1.6	1.6	1.5	1.5	1.5	1.5	1.5	-1.5
Intermittent access day 15 total locomotion	3.3	3.5	3.6	-1.9	-1.9	1.9	1.9	1.8	1.9	1.8	1.9	1.9	-1.9
Intermittent access total locomotion	4.6	5.3	6.4	-2.4	-2.5	2.4	2.3	2.2	2.2	2.2	2.2	2.2	-2.2
Intermittent access standard deviation	0.8	0.8	1.0	0.8	0.8	-0.8	-0.8	-1.0	-0.9	-0.9	-0.9	-0.9	0.9
Left kidney weight	0.6	1.6	2.0	-1.4	-1.4	1.4	1.3	1.2	1.1	1.1	1.2	1.2	-1.2
Right kidney weight	0.1	0.4	0.6	-0.7	-0.7	0.7	0.6	0.6	0.6	0.5	0.6	0.6	-0.6
Cocaine induced anxiety	1.0	1.1	1.4	-0.9	-0.6	0.9	1.0	1.2	1.2	1.2	1.2	1.2	-1.2
Post-drug Anxiety	1.6	1.8	2.0	-1.2	-1.1	1.2	1.3	1.4	1.4	1.4	1.4	1.4	-1.4
Baseline Anxiety	0.0	0.0	0.1	-0.0	-0.4	0.0	-0.0	-0.1	-0.1	-0.1	-0.1	-0.1	0.1
Tail length	7.5	22.6	24.7	-5.0	-4.8	5.0	4.9	4.7	4.7	4.8	4.6	4.6	-4.5
Length with tail	10.4	37.9	44.0	-6.4	-6.6	6.4	6.2	6.0	5.9	6.0	6.0	6.0	-5.9
Length without tail	5.7	12.6	16.8	-3.7	-4.1	3.7	3.6	3.4	3.3	3.3	3.5	3.5	-3.4
Times rat made contact with spout	0.4	0.4	0.6	0.7	0.7	-0.7	-0.7	-0.8	-0.5	-0.8	-0.5	-0.5	0.5
Lifetime Intake	2.1	2.3	2.5	-1.6	-1.4	1.6	1.6	1.5	1.6	1.5	1.6	1.6	-1.6
Liver weight, left	2.1	3.3	4.0	-1.8	-1.7	1.8	1.8	1.9	1.9	2.0	1.8	1.8	-1.7
Liver weight, right	0.0	0.0	0.1	0.1	0.0	-0.1	0.0	0.3	0.1	0.2	0.1	0.1	-0.2
Locomotor activity	0.1	0.1	0.2	0.1	-0.0	-0.1	-0.3	-0.4	-0.5	-0.5	-0.4	-0.4	0.4
Locomotor testing distance	1.3	2.1	2.7	1.3	1.1	-1.3	-1.4	-1.6	-1.5	-1.7	-1.5	-1.5	1.5
Locomotor testing rearing	0.5	0.7	1.3	0.8	1.1	-0.7	-0.7	-1.1	-0.8	-1.1	-0.7	-0.7	0.6
Locomotion in novel chamber	2.0	2.5	2.8	1.6	1.5	-1.6	-1.6	-1.7	-1.6	-1.6	-1.6	-1.6	1.6
Locomotion in novel chamber post-restriction	0.6	0.7	1.1	0.7	0.3	-0.8	-1.0	-0.6	-1.0	-0.5	-1.0	-1.0	1.0
Fecal boli incidents, locomotor time 1	2.8	3.1	3.5	1.8	1.8	-1.9	-1.9	-1.5	-1.8	-1.5	-1.8	-1.8	1.8
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.3	-0.4	0.3	0.3	0.2	0.3	0.2	0.3	0.3	-0.3
Time >=10cm from walls, locomotor time 1	1.8	1.8	2.3	1.3	1.5	-1.3	-1.3	-1.5	-1.2	-1.5	-1.2	-1.2	1.2
Bouts of movement, locomotor time 1	0.6	0.6	0.8	0.8	0.8	-0.8	-0.8	-0.6	-0.8	-0.6	-0.9	-0.9	0.9
Total resting periods, locomotor time 1	0.5	0.5	0.6	0.7	0.7	-0.7	-0.7	-0.5	-0.7	-0.5	-0.8	-0.8	0.8
Rest time, locomotor task time 1	2.9	3.2	3.6	1.8	1.6	-1.8	-1.9	-1.6	-1.8	-1.6	-1.9	-1.9	1.9
Distance moved, locomotor task time 1	2.1	2.3	3.3	-1.6	-1.8	1.7	1.6	1.2	1.4	1.2	1.5	1.5	-1.5
Vertical activity count, locomotor time 1	3.1	3.2	3.6	-1.8	-1.9	1.8	1.9	1.6	1.8	1.6	1.9	1.9	-1.9
Time >=10cm from walls, locomotor time 2	1.3	1.4	1.7	1.2	1.0	-1.2	-1.2	-1.2	-1.3	-1.2	-1.2	-1.2	1.2
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.0	0.0	0.0	0.1	-0.2	-0.0	-0.2	-0.1	-0.1	0.1
Total resting periods, locomotor time 2	0.2	0.3	0.4	0.4	0.5	-0.4	-0.4	-0.6	-0.5	-0.6	-0.5	-0.6	0.6
Rest time, locomotor task time 2	3.9	4.5	4.9	2.2	2.2	-2.2	-2.2	-2.0	-2.1	-2.0	-2.2	-2.2	2.2
Distance moved, locomotor task time 2	1.6	1.9	2.9	-1.5	-1.7	1.5	1.4	1.2	1.2	1.2	1.3	1.3	-1.3
Vertical activity count, locomotor time 2	1.2	1.3	2.1	-1.2	-1.4	1.2	1.1	1.2	1.0	1.2	1.1	1.1	-1.1
Light reinforcement 1	1.8	3.2	4.0	-2.0	-2.0	2.0	1.8	1.6	1.7	1.7	1.7	1.7	-1.7
Light reinforcement 2	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3	-0.2	-0.4	-0.3	-0.4	-0.4	0.3
Bone: marrow area	0.0	0.1	0.2	-0.1	-0.1	0.2	0.2	-0.2	-0.4	-0.2	-0.2	-0.2	0.3
Bone: maximum diameter	0.6	1.1	1.8	1.0	0.7	-1.0	-1.0	-1.1	-1.3	-1.1	-1.1	-1.1	1.2
Bone: maximum force	0.1	0.1	0.3	0.1	-0.1	-0.1	-0.2	-0.5	-0.5	-0.4	-0.4	-0.4	0.4
Bone: maximum moment	0.0	0.1	0.2	-0.1	-0.3	0.1	0.0	-0.3	-0.4	-0.3	-0.2	-0.2	0.2
Mean time between licks in bursts	0.0	0.1	0.1	0.2	0.0	-0.2	-0.1	-0.3	-0.3	-0.3	-0.3	-0.3	0.2
Mean num. licks in bursts	2.4	2.9	3.8	-1.7	-1.9	1.7	1.6	1.6	1.7	1.6	1.7	1.7	-1.7
Cd content in liver	0.3	0.4	0.6	-0.7	-0.7	0.8	0.8	0.3	0.6	0.3	0.6	0.6	-0.5
Co content in liver	0.1	0.1	0.3	-0.0	-0.2	0.1	0.1	-0.5	-0.0	-0.5	0.1	0.1	0.1
Cu content in liver	0.3	0.3	0.7	-0.6	-0.8	0.6	0.5	0.4	0.6	0.4	0.6	0.6	-0.5
Fe content in liver	2.2	2.6	3.4	-1.6	-1.5	1.6	1.5	1.8	1.5	1.9	1.6	1.6	-1.7
K content in liver	0.4	0.4	1.1	-0.8	-1.0	0.8	0.7	0.4	0.4	0.4	0.5	0.5	-0.7
Mg content in liver	0.1	0.1	0.2	0.2	-0.0	-0.2	-0.2	-0.5	-0.3	-0.5	-0.3	-0.3	0.2
Mn content in liver	0.2	0.2	0.4	-0.6	-0.7	0.6	0.6	0.3	0.2	0.3	0.4	0.4	-0.4
Na content in liver	0.1	0.1	0.1	-0.2	-0.3	0.2	0.1	0.4	0.2	0.3	0.2	0.2	-0.2
Rb content in liver	1.2	1.5	1.9	-1.1	-1.1	1.1	1.1	1.4	1.3	1.3	1.2	1.2	-1.3
Se content in liver	0.3	0.3	0.8	0.4	0.2	-0.4	-0.4	-0.9	-0.5	-0.9	-0.5	-0.5	0.5
Sr content in liver	3.9	3.6	4.0	1.9	1.7	-1.9	-1.9	-1.8	-2.0	-1.8	-1.9	-1.9	1.9
Zn content in liver	0.2	0.2	0.6	0.4	0.2	-0.4	-0.4	-0.7	-0.4	-0.7	-0.4	-0.4	0.4
Bone: minimum diameter	1.4	2.6	3.4	-1.7	-1.8	1.8	1.7	1.5	1.4	1.5	1.6	1.6	-1.5
Time in familiar zone, hab. session 1	3.5	3.3	4.0	-2.0	-1.9	2.0	2.0	1.6	1.7	1.6	1.7	1.7	-1.8
Time in novel zone, hab. session 1	3.7	3.6	5.5	2.1	2.3	-2.1	-2.0	-1.7	-1.7	-1.7	-1.7	-1.7	1.7
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.3	0.1	-0.3	-0.5	-0.4	-0.3	-0.4	-0.3	-0.3	0.4
Total locomotion distance, hab. session 1	0.2	0.3	0.6	0.5	0.3	-0.5	-0.7	-0.5	-0.7	-0.5	-0.7	-0.7	0.8
Locomotion velocity, hab. session 1	0.2	0.3	0.6	0.5	0.2	-0.5	-0.6	-0.5	-0.7	-0.5	-0.7	-0.7	0.8
Time in familiar zone, hab. session 2	1.3	1.3	1.7	-1.3	-1.2	1.3	1.3	1.2	1.0	1.2	1.0	1.0	-1.0
Time in novel zone, hab. session 2	2.0	2.0	2.6	1.5	1.3	-1.5	-1.6	-1.5	-1.3	-1.5	-1.3	-1.3	1.3
Total zone transitions, hab. session 2	0.0	0.1	0.1	-0.2	-0.4	0.2	0.2	0.2	0.2	0.2	0.2	0.2	-0.2
Total locomotion distance, hab. session 2	0.4	0.5	0.8	0.7	0.5	-0.7	-0.8	-0.7	-0.8	-0.7	-0.8	-0.8	0.9
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.2	0.2	-0.3	-0.3	-0.2	-0.4	-0.2	-0.4	-0.4	0.4
Novel to familiar place preference ratio	1.6	1.7	2.2	1.4	1.5	-1.3	-1.2	-1.4	-1.1	-1.4	-1.1	-1.1	1.1
Novelty place preference	1.2	1.2	1.6	1.1	1.3	-1.1	-1.0	-1.2	-1.0	-1.2	-1.0	-1.0	1.0
Time in novel zone, NPP test	1.2	1.2	1.6	1.2	1.3	-1.1	-1.1	-1.2	-1.0	-1.2	-1.0	-1.0	1.0
Total zone transitions, NPP test	1.2	1.7	2.0	-1.2	-1.4	1.2	1.1	1.4	1.3	1.4	1.3	1.3	-1.2
Total locomotion distance, NPP test	0.0	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1	0.0	0.1	0.0	0.0	0.1
Locomotion velocity, NPP test	0.3	0.4	0.6	-0.6	-0.6	0.6	0.6	0.8	0.7	0.8	0.7	0.7	-0.6
Intraocular pressure	3.3	4.6	5.2	2.0	1.9	-2.1	-2.2	-2.3	-2.2	-2.2	-2.1	-2.1	2.3
Delta distance traveled before/after self-admin	0.1	0.2	0.5	-0.5	-0.7	0.5	0.4	0.3	0.3	0.3	0.3	0.3	-0.3
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	-0.5	-0.7	0.5	0.5	0.4	0.4	0.4	0.4	0.4	-0.4
Parametrial fat weight	0.1	0.3	0.4	-0.4	-0.2	0.5	0.6	0.5	0.6	0.6	0.6	0.6	-0.5
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.0	-0.1	0.0	0.1	-0.0	-0.1	-0.0	-0.1	-0.1	0.0
Pavlov. Cond. magazine entry latency	2.1	2.7	4.0	-1.5	-1.3	1.5	1.5	2.0	1.6	2.0	1.7	1.7	-1.5
Pavlov. Cond. change in total contacts	2.0	2.1	2.3	-1.5	-1.3	1.5	1.4	1.5	1.4	1.5	1.4	1.4	-1.3
Pavlov. Cond. index score	0.4	0.5	0.6	-0.6	-0.5	0.5	0.6	0.8	0.8	0.8	0.8	0.8	-0.6
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.2	-0.2	0.2	0.2	0.4	0.4	0.5	0.4	0.4	-0.3
Pavlov. Cond. lever contacts	0.2	0.2	0.3	-0.5	-0.4	0.4	0.4	0.5	0.6	0.5	0.6	0.6	-0.4
Pavlov. Cond. magazine entry number	1.3	1.6	2.1	1.2	1.1	-1.1	-1.1	-1.5	-1.3	-1.5	-1.3	-1.3	1.2
Pavlov. Cond. intertrial magazine entries	3.1	3.8	4.4	2.1	2.0	-2.0	-2.0	-2.1	-1.8	-2.1	-1.8	-1.8	1.8
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	0.9	-0.7	-0.6	0.7	0.7	1.0	0.9	1.0	0.9	1.0	-0.8
Pavlov. Cond. response bias	1.6	1.9	2.6	-1.3	-1.2	1.3	1.3	1.6	1.4	1.6	1.4	1.4	-1.2
Pavlov. Cond. lever latency	0.4	0.6	1.0	0.9	1.0	-0.9	-0.6	-0.6	-0.7	-0.7	-0.7	-0.7	0.8
Pavlov. Cond. magazine entry latency	0.2	0.2	0.8	-0.5	-0.9	0.5	0.5	0.1	0.3	0.1	0.3	0.3	-0.4
Pavlov. Cond. change in total contacts	2.0	2.8	4.7	-1.9	-2.2	1.9	1.7	1.3	1.5	1.4	1.5	1.5	-1.7
Pavlov. Cond. index score	0.8	1.1	2.0	-1.2	-1.4	1.1	1.0	0.7	0.9	0.8	1.0	1.0	-1.1
Pavlov. Cond. latency score	1.0	1.2	2.2	-1.2	-1.5	1.2	1.1	0.8	1.0	0.9	1.0	1.0	-1.1
Pavlov. Cond. lever contacts	0.7	1.0	1.6	-1.1	-1.2	1.1	0.9	0.8	1.0	0.8	1.0	1.0	-1.1
Pavlov. Cond. magazine entry number	0.3	0.4	1.3	0.7	1.1	-0.7	-0.6	-0.3	-0.5	-0.3	-0.5	-0.5	0.7
Pavlov. Cond. intertrial magazine entries	1.2	1.6	2.1	-1.0	-0.7	1.0	1.2	1.5	1.4	1.4	1.4	1.4	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	2.3	-1.2	-1.5	1.2	1.0	0.7	1.0	0.8	1.0	1.0	-1.1
Pavlov. Cond. response bias	0.4	0.6	1.4	-0.9	-1.2	0.9	0.7	0.4	0.7	0.4	0.7	0.7	-0.9
Time in closed arm before self-admin	0.9	1.0	1.5	-0.7	-0.1	0.7	0.9	1.0	1.2	1.0	1.2	1.2	-1.2
Time in closed arm after self-admin	0.7	0.7	1.0	0.8	1.0	-0.8	-0.8	-0.9	-0.8	-0.9	-0.8	-0.8	0.8
Time in open arm before self-admin	0.2	0.3	0.4	0.2	-0.3	-0.2	-0.4	-0.6	-0.7	-0.6	-0.7	-0.7	0.7
Time in open arm after self-admin	0.1	0.1	0.2	0.4	0.4	-0.4	-0.4	-0.3	-0.3	-0.3	-0.3	-0.3	0.3
Bone: periosteal estimation	0.0	0.0	0.1	-0.3	-0.4	0.3	0.3	0.1	-0.1	0.1	0.1	0.1	-0.0
Bone: periosteal perimeter	0.1	0.1	0.3	0.1	-0.0	-0.1	-0.2	-0.4	-0.5	-0.4	-0.4	-0.4	0.3
Bone: post-yield work	0.1	0.1	0.3	0.2	0.2	-0.2	-0.3	-0.5	-0.5	-0.4	-0.3	-0.3	0.4
Progressive ratio test 1 active lever presses	0.8	0.9	1.1	-1.0	-0.7	1.0	1.0	0.9	0.9	0.9	0.9	0.9	-0.9
Progressive ratio test 1 breakpoint	0.8	0.9	1.0	-1.0	-0.7	1.0	1.0	0.9	0.9	0.9	0.9	0.9	-0.9
Progressive ratio test 1 inactive lever presses	0.7	0.8	0.9	-0.9	-0.6	0.9	0.9	0.9	0.9	0.9	0.9	0.9	-0.9
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.3	-0.3	0.3	0.2	0.0	0.1	0.1	0.1	0.1	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.2	-0.2	0.2	0.1	-0.0	0.0	-0.0	0.0	0.0	-0.0
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.4	-0.6	-0.5	0.6	0.6	0.6	0.5	0.5	0.5	0.5	-0.5
Incentive Sensitization - Responses	0.1	0.1	0.4	-0.5	-0.6	0.4	0.3	0.2	0.2	0.2	0.2	0.2	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.3	-0.5	0.3	0.2	0.1	0.1	0.1	0.1	0.1	-0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.6	0.4	0.8	-0.4	-0.3	-0.1	-0.1	-0.1	-0.1	-0.1	0.1
Progressive ratio	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.2	-0.1	-0.1	-0.1	-0.1	0.1
Food seeking constrained by brief footshock	2.8	3.5	4.2	-1.8	-2.1	1.7	1.7	2.0	1.9	2.0	1.8	1.8	-1.8
Seeking ratio, punishment vs. effort	1.2	1.5	1.9	-1.2	-1.1	1.2	1.2	1.4	1.3	1.3	1.2	1.2	-1.2
Retroperitoneal fat weight	0.1	0.4	0.8	0.7	0.9	-0.7	-0.5	-0.6	-0.6	-0.6	-0.6	-0.6	0.5
Reaction time number correct	10.1	14.5	16.1	-3.8	-3.6	3.8	3.8	3.7	4.0	3.7	4.0	4.0	-3.8
Reaction time mean minus median	0.1	0.1	0.3	-0.2	-0.3	0.1	-0.0	0.6	0.2	0.6	0.2	0.2	-0.2
Reaction time mean minus median AUC	0.2	0.2	0.5	-0.5	-0.7	0.5	0.3	0.6	0.3	0.7	0.3	0.3	-0.4
Reaction time num false alarms	0.9	1.2	1.7	1.0	1.0	-1.0	-1.0	-1.3	-0.9	-1.3	-1.1	-1.1	1.2
Reaction time num false alarms AUC	1.6	2.2	3.0	1.4	1.2	-1.4	-1.5	-1.7	-1.3	-1.7	-1.5	-1.5	1.6
Reaction time trials correct on left	10.1	14.5	16.1	-3.8	-3.6	3.8	3.8	3.7	4.0	3.7	4.0	4.0	-3.8
Reaction time trials on left	10.6	15.1	16.7	-3.8	-3.7	3.8	3.8	3.8	4.1	3.8	4.0	4.0	-3.9
Reaction time mean	1.3	1.8	2.4	1.5	1.5	-1.5	-1.5	-1.3	-1.2	-1.2	-1.1	-1.1	1.2
Reaction time mean AUC	1.0	1.4	2.0	1.4	1.4	-1.4	-1.4	-1.1	-1.1	-1.0	-1.0	-1.0	1.0
Median of all reaction times	2.3	3.1	4.1	1.9	2.0	-1.9	-1.9	-1.9	-1.6	-1.8	-1.5	-1.5	1.5
Reaction time omissions	1.3	1.7	2.9	-1.1	-0.8	1.0	1.0	1.7	1.4	1.7	1.4	1.4	-1.4
Reaction time false alarm rate	7.5	10.4	11.6	3.1	2.9	-3.1	-3.2	-3.4	-3.2	-3.4	-3.3	-3.3	3.4
Reaction time premature initiation rate	1.7	2.2	2.9	-1.7	-1.7	1.7	1.6	1.4	1.3	1.3	1.4	1.4	-1.4
Reaction time premature initiations	8.1	11.5	12.8	-3.6	-3.5	3.6	3.4	3.2	3.3	3.2	3.4	3.4	-3.3
Std. dev. reaction times	0.0	0.1	0.2	0.3	0.3	-0.4	-0.5	0.1	-0.1	0.2	-0.1	-0.1	0.1
Reaction time trials completed	10.6	15.1	16.7	-3.8	-3.7	3.8	3.8	3.8	4.1	3.8	4.0	4.0	-3.9
Reaction time trials AUC	9.3	13.5	14.9	-3.6	-3.4	3.6	3.6	3.6	3.9	3.6	3.8	3.8	-3.7
Run reversals in cocaine runway, females	0.5	0.5	0.6	0.7	0.6	-0.7	-0.7	-0.5	-0.8	-0.7	-0.8	-0.8	0.8
Run reversals in cocaine runway, males	0.3	0.3	0.6	0.5	0.8	-0.5	-0.5	-0.6	-0.4	-0.6	-0.5	-0.5	0.5
Latency to leave start box in cocaine runway	3.4	3.6	4.3	1.9	2.1	-1.9	-2.0	-1.9	-1.9	-1.9	-1.8	-1.8	1.8
Latency to leave start box in cocaine runway, F	1.0	1.1	1.3	1.0	0.5	-1.0	-1.1	-1.2	-1.1	-1.1	-1.1	-1.1	1.1
Latency to leave start box in cocaine runway, M	2.9	2.8	5.1	1.7	2.3	-1.7	-1.6	-1.5	-1.6	-1.5	-1.5	-1.5	1.5
Std. dev. time between licks in bursts	0.8	1.0	1.3	1.0	1.1	-1.0	-0.9	-1.0	-0.9	-1.0	-0.9	-0.9	0.9
Total sessions with >9 infusions	0.5	0.5	0.7	-0.8	-0.7	0.8	0.8	0.6	0.7	0.6	0.7	0.7	-0.7
Short access day 1 total inactive lever presses	0.4	0.5	0.6	-0.6	-0.4	0.6	0.7	0.7	0.8	0.8	0.8	0.8	-0.8
Short access day 10 total inactive lever presses	0.7	0.8	1.0	0.9	1.0	-0.9	-0.9	-0.9	-0.9	-0.8	-0.9	-0.9	0.9
Short access day 1 total infusions	2.0	2.2	2.4	-1.4	-1.2	1.4	1.5	1.5	1.6	1.5	1.6	1.6	-1.6
Short access day 10 total infusions	1.1	1.2	1.3	-1.2	-1.0	1.2	1.1	1.1	1.1	1.1	1.1	1.1	-1.1
Short access total infusions	2.0	2.2	2.3	-1.5	-1.4	1.5	1.5	1.4	1.5	1.5	1.5	1.5	-1.5
Short access day 1 locomotion	0.3	0.4	0.7	-0.6	-0.8	0.6	0.6	0.5	0.6	0.5	0.6	0.6	-0.6
Short access day 10 total locomotion	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	-0.1	-0.0	-0.0	-0.0	-0.0	0.0
Short access total locomotion	1.8	1.9	2.3	-1.5	-1.5	1.5	1.4	1.2	1.3	1.3	1.3	1.3	-1.3
One hour access (0.3 mA shock)	1.2	1.4	1.6	-1.3	-0.8	1.3	1.3	1.2	1.2	1.2	1.2	1.2	-1.2
Compulsive drug intake	0.3	0.3	0.4	0.5	0.3	-0.5	-0.5	-0.6	-0.6	-0.6	-0.6	-0.6	0.6
One hour access (shock baseline)	2.9	3.4	3.7	-1.8	-1.3	1.8	1.9	1.9	1.9	1.9	1.9	1.9	-1.9
Social response proportion	0.1	0.1	0.1	0.2	0.2	-0.3	-0.3	-0.0	-0.3	-0.1	-0.3	-0.3	0.4
Social responses	0.4	0.5	0.8	-0.8	-0.9	0.8	0.7	0.8	0.6	0.7	0.6	0.6	-0.5
Social time	0.3	0.4	0.7	-0.5	-0.1	0.5	0.6	0.8	0.6	0.8	0.7	0.7	-0.8
Soleus weight	0.0	0.0	0.1	0.1	0.4	-0.1	0.0	-0.1	-0.0	-0.1	0.1	0.1	-0.1
Bone: stiffness	0.0	0.0	0.1	-0.1	-0.4	0.1	0.0	-0.2	-0.2	-0.1	-0.2	-0.2	0.1
Tibialis anterior weight	2.1	7.3	8.1	2.8	2.7	-2.8	-2.8	-2.7	-2.6	-2.7	-2.5	-2.5	2.8
Time to tail flick, vehicle, before self-admin	3.8	3.9	4.5	-2.1	-1.8	2.1	2.1	1.9	2.0	1.9	2.0	2.0	-2.0
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.8	-0.7	-0.9	0.7	0.5	0.4	0.5	0.4	0.5	0.5	-0.5
Time to tail flick, test, before self-admin	0.3	0.3	0.3	-0.5	-0.3	0.5	0.6	0.5	0.6	0.5	0.5	0.6	-0.6
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.1	0.0	-0.1	-0.0	-0.3	-0.2	-0.3	-0.2	-0.2	0.2
Delta time to tail flick, vehicle, before/after SA	2.3	2.2	2.6	1.5	1.2	-1.5	-1.6	-1.5	-1.5	-1.5	-1.5	-1.5	1.5
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.2	-0.1	-0.2	-0.1	-0.1	0.1
Tibia length	6.2	17.5	18.4	-4.3	-4.3	4.3	4.2	4.0	4.1	4.0	4.3	4.3	-4.1
Ambulatory time before self-admin	0.8	0.8	1.0	-0.8	-1.0	0.8	0.8	1.0	0.8	1.0	0.8	0.8	-0.9
Ambulatory time after self-admin	1.2	1.4	1.9	-1.1	-1.4	1.1	1.1	1.3	1.1	1.3	1.1	1.1	-1.1
Bone: tissue strength	1.7	1.7	2.0	1.2	1.0	-1.2	-1.3	-1.4	-1.4	-1.3	-1.4	-1.4	1.3
Total heroin consumption	0.3	0.3	0.8	0.7	0.9	-0.7	-0.5	-0.6	-0.4	-0.6	-0.4	-0.4	0.4
Bone: trabecular number	0.1	0.2	0.3	0.4	0.4	-0.4	-0.5	-0.4	-0.3	-0.4	-0.4	-0.4	0.5
Bone: trabecular spacing	0.4	0.5	0.7	-0.6	-0.3	0.6	0.7	0.6	0.8	0.7	0.8	0.8	-0.7
Bone: trabecular thickness	2.1	2.5	3.0	1.5	1.4	-1.5	-1.6	-1.5	-1.7	-1.5	-1.7	-1.7	1.6
Bone: trabecular tissue density	2.9	4.1	5.0	1.9	1.7	-1.8	-1.8	-2.1	-2.2	-2.2	-2.2	-2.2	2.0
Water consumed over 24 hours	1.1	1.3	1.5	1.1	1.0	-1.1	-1.2	-1.2	-1.1	-1.2	-1.1	-1.1	1.1
Number of responses in last shaping day	0.2	0.2	0.4	0.5	0.6	-0.5	-0.4	-0.5	-0.4	-0.5	-0.4	-0.4	0.4