Hub : Genes

Masp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative polyA XM_006239401.4 0.21 0.11 0.0e+00 0.19 0.21 0.2 0.2 8.8e-21 1.3e-22 2.2e-21 1.1e-21
2 Liver isoform ratio NM_172043.1 0.2 0.1 0.0e+00 0.19 0.2 0.19 0.2 1.7e-20 5.0e-22 8.0e-21 2.0e-21
3 Brain gene expression Masp2 0.08 0.05 3.5e-10 0.11 0.11 0.11 0.11 3.8e-10 3.0e-10 4.8e-10 3.3e-10
4 Liver alternative polyA NM_172043.1 0.17 0.09 0.0e+00 0.17 0.18 0.17 0.17 3.4e-18 2.5e-19 7.6e-19 4.7e-19
5 Brain alternative polyA NM_172043.1 0.04 0.03 1.5e-04 0.05 0.04 0.03 0.04 3.2e-05 1.0e-04 1.5e-03 2.0e-04
6 Brain alternative polyA XM_063288351.1 0.04 0.03 8.0e-05 0.05 0.04 0.03 0.04 1.8e-05 5.2e-05 4.8e-04 1.2e-04
7 Liver isoform ratio XM_006239401.4 0.18 0.09 0.0e+00 0.2 0.21 0.2 0.2 1.6e-21 1.8e-22 1.8e-21 5.8e-22
8 Liver intron excision ratio chr5_164320359_164321967 0.13 0.06 0.0e+00 0.13 0.12 0.12 0.12 8.1e-14 1.1e-13 4.3e-13 1.2e-13
9 NAcc gene expression Masp2 0.02 0.01 5.8e-04 0.02 0.02 0.01 0.02 8.9e-04 1.2e-03 3.9e-03 1.2e-03
10 Liver intron excision ratio chr5_164320359_164320805 0.11 0.06 3.9e-16 0.11 0.12 0.11 0.11 4.9e-12 8.2e-13 1.9e-12 1.9e-12
11 Liver mRNA stability Masp2 0.07 0.04 7.7e-10 0.06 0.07 0.06 0.06 1.0e-06 1.3e-08 3.1e-07 5.0e-07
12 Liver gene expression Masp2 0.25 0.13 0.0e+00 0.2 0.22 0.22 0.21 1.2e-21 4.1e-24 1.2e-23 5.8e-23
13 PL gene expression Masp2 0.05 0.04 3.2e-04 0.03 0.03 0.02 0.03 1.9e-04 6.4e-04 1.2e-03 5.8e-04
14 NAcc alternative polyA XM_063288351.1 0.02 0.01 4.3e-03 0.01 0.01 0 0.01 2.2e-03 1.4e-02 1.6e-01 2.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.00.00.10.1-0.1-0.2-0.10.1-0.10.1-0.3-0.10.10.0-0.2-0.1-0.1
Area under the delay curve0.91.11.71.0-1.0-1.0-1.01.2-1.20.9-0.8-1.30.90.90.9-1.1-1.1
BMI with tail0.00.00.10.1-0.0-0.1-0.1-0.20.2-0.0-0.3-0.10.10.1-0.2-0.1-0.2
BMI without tail0.10.40.9-0.80.80.60.7-0.50.5-0.80.20.6-0.7-0.7-0.90.50.5
Body weight0.41.82.3-1.51.51.41.4-1.31.3-1.50.81.3-1.4-1.3-1.31.21.2
Weight adjusted by age1.11.62.6-1.21.11.51.2-1.41.4-0.91.41.6-1.1-0.9-0.41.61.6
Bone surface0.40.81.2-0.80.80.90.8-0.90.9-0.70.81.0-0.8-0.8-0.71.11.1
Bone volume0.10.20.3-0.30.30.40.4-0.40.4-0.30.40.5-0.4-0.4-0.40.50.5
Breakpoint value in progressive ratio session0.20.30.8-0.20.20.20.2-0.80.8-0.2-0.10.70.00.1-0.50.90.9
Number of licking bursts1.42.33.31.8-1.8-1.7-1.71.4-1.41.7-1.3-1.21.71.61.3-1.2-1.2
Context. condit. distance diff. score4.14.95.92.4-2.3-2.4-2.32.2-2.22.2-2.0-2.32.22.11.7-2.3-2.3
Locomotion velocity, session 10.10.10.30.4-0.4-0.4-0.40.3-0.30.4-0.5-0.10.40.50.3-0.2-0.1
Locomotion distance, session 10.00.00.10.0-0.0-0.1-0.00.1-0.1-0.0-0.3-0.00.10.0-0.20.00.0
Locomotion velocity, session 20.70.81.31.0-1.0-0.9-1.00.8-0.81.1-0.7-0.61.01.11.1-0.5-0.5
Locomotion distance, session 20.10.10.4-0.40.40.40.3-0.30.3-0.30.10.5-0.3-0.2-0.20.60.6
Locomotion velocity, session 30.91.01.11.0-1.0-1.0-1.01.0-1.01.0-1.0-0.91.11.11.0-1.0-1.0
Locomotion distance, session 30.70.71.00.9-0.9-0.9-0.90.8-0.80.9-0.7-0.81.01.00.9-0.8-0.8
Stereotopy head waving bouts, day 30.00.00.0-0.20.20.20.1-0.20.2-0.1-0.10.2-0.1-0.1-0.00.10.1
Stereotopy head waving duration, day 30.20.30.4-0.70.70.60.6-0.50.5-0.60.20.4-0.6-0.6-0.50.40.4
Locomotion velocity, session 70.20.20.60.7-0.7-0.5-0.60.1-0.10.8-0.1-0.10.60.60.7-0.2-0.1
Locomotion distance, session 70.00.00.1-0.10.10.20.1-0.40.4-0.00.20.4-0.1-0.00.10.20.2
Stereotopy head waving bouts, day 72.42.73.01.7-1.7-1.7-1.71.7-1.71.7-1.4-1.71.61.61.5-1.7-1.6
Stereotopy head waving duration, day 70.91.11.61.0-1.0-1.1-1.01.2-1.21.0-0.9-1.31.00.90.8-1.2-1.2
Locomotion velocity, session 83.23.95.02.2-2.2-2.1-2.21.7-1.72.2-1.9-1.62.22.22.0-1.5-1.5
Locomotion distance, session 82.43.54.32.0-2.0-2.1-2.01.8-1.81.9-1.9-1.72.01.91.6-1.8-1.8
Degree of sensitization distance0.30.30.4-0.60.60.60.5-0.60.6-0.50.40.5-0.5-0.5-0.30.40.4
Degree of sensitization stereotypy0.90.91.11.1-1.1-1.0-1.01.0-1.01.0-0.7-1.01.00.90.8-0.9-0.9
Conditioned locomotion3.94.54.82.2-2.2-2.2-2.22.1-2.12.2-1.9-2.12.12.12.1-2.0-2.0
Cocaine response after cond. corrected0.70.91.1-1.01.01.11.0-0.90.9-0.90.91.0-1.0-0.9-0.70.90.9
Cocaine response after cond. not corrected0.80.91.2-1.11.11.11.0-0.90.9-1.00.91.0-1.0-0.9-0.60.90.9
Cocaine response before conditioning0.00.00.0-0.20.20.20.1-0.20.2-0.1-0.00.1-0.1-0.00.10.20.1
Saline control response0.60.81.3-0.90.90.80.9-0.90.9-1.00.60.9-0.9-0.9-1.21.00.9
Bone: connectivity density0.00.00.0-0.00.00.10.1-0.00.0-0.0-0.1-0.1-0.0-0.1-0.20.10.1
Bone: cortical apparent density1.92.64.5-1.51.51.61.6-1.61.6-1.52.11.5-1.6-1.6-1.41.51.5
Bone: cortical area1.21.93.0-1.21.31.21.3-1.41.4-1.41.21.5-1.3-1.4-1.71.41.4
Bone: cortical porosity1.11.21.41.1-1.1-1.1-1.11.1-1.11.1-1.2-1.01.11.11.0-1.0-1.0
Bone: cortical porosity0.90.91.11.0-1.0-1.0-1.01.0-1.01.0-1.1-0.81.01.01.0-0.9-0.9
Bone: cortical thickness0.40.71.4-0.50.60.50.6-1.01.0-0.70.91.0-0.7-0.8-1.20.80.8
Bone: cortical thickness0.30.30.9-0.40.40.30.5-0.60.6-0.50.60.6-0.5-0.6-0.90.50.5
Bone: cortical tissue density1.92.64.4-1.51.51.71.6-1.61.6-1.52.11.5-1.6-1.6-1.51.51.5
Condit. Reinf. active minus inactive responses1.11.21.8-1.31.31.21.2-1.11.1-1.30.81.0-1.2-1.1-1.00.90.9
Condit. Reinf. active-inactive response ratio3.33.54.7-2.22.22.02.1-1.71.7-2.11.71.5-2.1-2.0-1.81.51.5
Condit. Reinf. active responses0.00.00.0-0.10.10.10.1-0.10.1-0.1-0.10.10.00.10.2-0.00.0
Condit. Reinf. inactive responses4.15.06.22.3-2.4-2.2-2.42.1-2.12.4-2.0-2.02.42.42.5-2.0-1.9
Incentive salience index mean3.34.04.7-2.22.12.22.1-2.12.1-2.01.92.1-2.0-1.8-1.52.02.0
Condit. Reinf. lever presses2.63.64.4-1.91.92.11.9-2.02.0-1.72.02.1-1.8-1.7-1.42.02.1
Condit. Reinf. active minus inactive responses0.60.70.90.8-0.8-0.8-0.90.9-0.90.9-0.8-0.80.91.01.0-0.8-0.7
Condit. Reinf. active-inactive response ratio0.20.30.50.5-0.5-0.4-0.50.7-0.70.5-0.4-0.50.50.50.6-0.5-0.5
Condit. Reinf. active responses0.91.21.71.1-1.1-1.0-1.21.1-1.11.2-1.0-1.01.21.31.3-0.9-0.9
Condit. Reinf. inactive responses0.00.00.1-0.10.10.20.1-0.30.3-0.10.10.3-0.1-0.0-0.10.30.3
Condit. Reinf. lever presses0.10.10.30.4-0.4-0.3-0.40.1-0.10.4-0.4-0.10.50.50.4-0.00.0
Condit. Reinf. lever reinforcers received0.81.21.61.1-1.1-1.0-1.11.0-1.01.2-1.0-0.91.21.31.2-0.8-0.8
Conditioned reinforcement - actives0.71.21.31.1-1.1-1.1-1.11.1-1.11.1-1.1-1.01.11.11.0-1.1-1.1
Conditioned reinforcement - inactives0.00.00.1-0.10.10.00.10.3-0.3-0.1-0.0-0.2-0.1-0.1-0.1-0.2-0.2
Conditioned locomotion1.21.62.21.3-1.4-1.2-1.31.1-1.11.4-1.0-1.01.41.41.5-1.0-1.0
Patch foraging indifference point 0 sec0.71.31.7-1.21.21.21.2-1.01.0-1.30.81.0-1.3-1.3-1.31.01.0
Patch foraging indifference point AUC0.20.30.8-0.40.40.40.4-0.70.7-0.50.90.6-0.5-0.6-0.80.50.5
Delay disc. indifference point, 0s delay0.60.71.40.7-0.7-0.8-0.71.0-1.00.6-0.7-1.20.60.50.4-1.0-1.0
Delay disc. indifference point, 16s delay1.41.61.91.3-1.3-1.2-1.31.3-1.31.3-1.2-1.21.21.21.4-1.2-1.2
Delay disc. indifference point, 2s delay0.50.51.10.7-0.7-0.8-0.71.0-1.00.6-0.4-1.00.60.50.3-0.8-0.8
Delay disc. indifference point, 24s delay0.30.30.4-0.60.60.60.6-0.60.6-0.60.30.7-0.6-0.6-0.50.50.5
Delay disc. indifference point, 4s delay0.20.30.80.4-0.4-0.5-0.40.7-0.70.3-0.3-0.90.30.20.2-0.6-0.6
Delay disc. indifference point, 8s delay0.20.20.40.4-0.4-0.4-0.40.6-0.60.4-0.4-0.60.40.30.4-0.4-0.4
Indifference point function ln k0.10.10.2-0.40.40.20.30.4-0.4-0.4-0.3-0.4-0.3-0.3-0.0-0.3-0.3
Indifference point function log k0.10.10.2-0.40.40.20.30.4-0.4-0.4-0.3-0.4-0.3-0.3-0.0-0.3-0.3
Patch foraging total patch changes 0 sec0.71.31.6-1.21.21.21.2-1.11.1-1.30.71.1-1.2-1.3-1.31.01.0
Patch foraging total patch changes 12 sec0.70.91.5-0.80.80.90.8-1.21.2-0.81.01.1-0.8-0.8-0.90.90.9
Patch foraging total patch changes 18 sec0.30.50.9-0.60.60.70.6-1.01.0-0.60.71.0-0.7-0.7-0.70.70.7
Patch foraging total patch changes 24 sec0.50.81.6-0.80.80.70.9-1.11.1-0.90.80.9-0.9-1.0-1.30.70.7
Patch foraging total patch changes 6 sec2.53.85.5-2.02.01.92.0-1.71.7-2.21.81.7-2.1-2.2-2.31.71.7
Patch foraging time to switch 0 sec0.51.12.7-0.70.70.90.7-1.31.3-0.60.91.6-0.6-0.6-0.61.51.5
Patch foraging water rate 0 sec0.51.12.30.8-0.8-0.9-0.81.2-1.20.7-0.9-1.50.70.70.8-1.4-1.4
Patch foraging water rate 12 sec0.00.10.2-0.10.2-0.00.10.2-0.2-0.2-0.1-0.4-0.2-0.3-0.1-0.4-0.4
Patch foraging water rate 18 sec0.00.10.1-0.40.40.40.3-0.20.2-0.30.20.1-0.3-0.30.10.10.2
Patch foraging water rate 24 sec0.20.30.5-0.60.60.60.6-0.60.6-0.60.70.6-0.6-0.6-0.30.60.6
Patch foraging water rate 6 sec0.30.41.00.4-0.4-0.6-0.40.9-0.90.3-0.8-1.00.30.20.2-0.8-0.8
Seeking ratio, delayed vs. immediate footshock0.10.20.6-0.40.40.20.4-0.40.4-0.60.00.1-0.4-0.5-0.80.30.3
Distance traveled before self-admin0.10.20.90.3-0.4-0.1-0.40.4-0.40.5-0.1-0.10.40.50.9-0.1-0.1
Distance traveled after self-admin0.10.10.4-0.20.10.40.1-0.20.20.10.30.30.00.10.60.40.4
Extensor digitorum longus weight0.10.40.70.6-0.6-0.7-0.60.7-0.70.5-0.8-0.70.60.60.4-0.8-0.7
Bone: elastic displacement6.57.59.22.8-2.8-2.8-2.82.7-2.72.7-3.0-2.62.82.72.5-2.7-2.7
Bone: elastic work3.74.86.02.4-2.3-2.4-2.32.1-2.12.2-2.4-2.02.22.21.7-2.1-2.1
Bone: endosteal estimation1.02.23.0-1.51.51.61.5-1.41.4-1.41.31.6-1.4-1.4-1.11.71.7
Bone: endosteal perimeter0.71.51.7-1.31.31.31.3-1.21.2-1.31.01.3-1.2-1.2-1.11.31.3
Epididymis fat weight1.44.86.4-2.52.52.42.4-2.22.2-2.41.52.0-2.3-2.2-2.01.91.9
Delta time in closed arm before/after self-admin0.00.00.1-0.20.30.20.2-0.10.1-0.30.20.2-0.2-0.2-0.30.10.1
Delta time in open arm before/after self-admin0.10.10.2-0.20.20.10.2-0.40.4-0.3-0.10.3-0.1-0.2-0.40.10.1
Diff in mean of infusions in LGA sessions0.20.30.40.7-0.6-0.6-0.60.4-0.40.6-0.5-0.40.60.60.4-0.4-0.4
Delay discount exponential model param0.70.81.4-0.80.80.90.8-1.11.1-0.80.71.2-0.8-0.7-0.71.01.0
Extinction: sum of active levers before priming0.00.00.10.0-0.00.10.00.2-0.20.10.2-0.10.00.10.3-0.0-0.0
Active lever presses in extinction session 60.10.10.2-0.20.20.20.2-0.40.4-0.10.20.5-0.1-0.0-0.10.40.4
Bone: final force0.91.42.3-1.01.01.01.1-1.21.2-1.11.31.3-1.2-1.2-1.51.21.2
Bone: final moment0.40.71.1-0.70.70.70.7-0.80.8-0.80.90.9-0.8-0.9-1.10.80.8
Food consumed during 24 hour testing period0.00.00.3-0.00.00.1-0.1-0.00.00.2-0.10.20.20.40.60.00.1
Glucose0.10.10.5-0.30.40.00.30.0-0.0-0.5-0.3-0.4-0.3-0.4-0.7-0.3-0.4
Heart weight12.819.728.64.3-4.2-4.6-4.34.6-4.64.0-5.3-4.54.34.23.7-4.7-4.6
Delay discount hyperbolic model param0.91.01.7-0.90.91.00.9-1.21.2-0.90.81.3-0.9-0.8-0.81.11.1
Intermittent access intake day 1-15 change0.20.40.90.5-0.5-0.5-0.51.0-1.00.5-0.5-0.60.50.50.6-0.6-0.6
Intermittent access intake escalation0.20.30.90.5-0.5-0.4-0.51.0-1.00.5-0.3-0.40.50.40.6-0.4-0.4
Intermittent access intake escalation 20.50.60.90.9-0.9-0.8-0.90.8-0.80.9-0.7-0.60.90.90.8-0.5-0.5
Intermitt. access day 1 inactive lever presses0.00.20.3-0.40.40.40.4-0.60.6-0.40.30.3-0.4-0.4-0.40.30.3
Intermitt. access day 15 inactive lever presses0.10.30.5-0.40.40.50.4-0.60.6-0.40.60.7-0.4-0.4-0.50.70.7
Intermitt. access escalation Index0.10.20.30.5-0.5-0.4-0.50.1-0.10.5-0.4-0.10.50.60.4-0.1-0.1
Intermittent access day 1 total infusions2.23.54.4-1.81.91.81.9-1.91.9-1.91.91.8-1.8-1.9-2.11.81.8
Intermittent access day 15 total infusions1.42.12.6-1.51.51.51.5-1.11.1-1.51.61.4-1.5-1.6-1.61.41.4
Intermittent access terminal intake (last 3 days)3.64.75.0-2.12.12.22.1-2.22.2-2.12.22.2-2.1-2.1-2.22.22.2
Intermittent access total infusions4.45.26.2-2.32.32.22.3-2.22.2-2.32.32.2-2.3-2.3-2.52.22.2
Intermittent access day 1 locomotion3.64.65.8-2.02.02.12.0-2.42.4-2.02.12.2-2.0-2.0-2.12.32.3
Intermittent access day 15 total locomotion0.40.81.0-0.80.80.90.8-0.90.9-0.81.01.0-0.8-0.8-0.81.01.0
Intermittent access total locomotion2.22.73.1-1.61.61.61.6-1.71.7-1.61.61.8-1.5-1.5-1.61.81.8
Intermittent access standard deviation0.10.20.4-0.30.30.30.3-0.60.6-0.40.40.4-0.3-0.4-0.60.40.4
Left kidney weight0.00.00.10.2-0.2-0.3-0.20.1-0.10.1-0.2-0.00.20.2-0.1-0.1-0.1
Right kidney weight0.00.00.2-0.10.2-0.10.1-0.10.1-0.3-0.40.1-0.1-0.1-0.4-0.0-0.0
Cocaine induced anxiety1.11.62.31.5-1.5-1.3-1.41.0-1.01.5-1.1-0.81.41.41.4-0.9-0.9
Post-drug Anxiety1.01.01.41.1-1.1-1.0-1.01.2-1.21.1-0.9-0.91.00.91.0-1.0-1.0
Baseline Anxiety0.50.61.1-1.01.00.91.0-0.30.3-1.10.60.4-1.1-1.1-0.90.30.3
Tail length0.62.53.1-1.81.81.61.7-1.11.1-1.81.11.6-1.8-1.8-1.51.51.6
Length with tail0.83.64.7-2.22.22.02.1-1.61.6-2.11.31.9-2.0-2.0-1.71.71.8
Length without tail0.10.20.60.3-0.3-0.4-0.30.4-0.40.3-0.8-0.40.40.40.4-0.5-0.5
Times rat made contact with spout0.10.10.3-0.40.30.50.3-0.30.3-0.20.20.5-0.2-0.1-0.00.60.6
Lifetime Intake3.84.65.3-2.12.12.12.1-2.12.1-2.12.22.2-2.1-2.1-2.32.22.2
Liver weight, left3.86.28.3-2.52.52.52.5-2.62.6-2.42.32.9-2.4-2.3-2.22.72.7
Liver weight, right3.05.36.4-2.52.52.52.4-2.32.3-2.41.92.3-2.4-2.3-1.92.22.2
Locomotor activity4.06.27.22.7-2.7-2.7-2.72.3-2.32.6-2.5-2.22.72.72.3-2.3-2.2
Locomotor testing distance2.34.25.12.2-2.2-2.1-2.21.9-1.92.3-1.8-1.62.22.22.2-1.8-1.8
Locomotor testing rearing0.10.20.5-0.10.10.30.1-0.50.50.00.50.7-0.00.00.20.70.7
Locomotion in novel chamber1.11.42.61.1-1.1-1.1-1.11.1-1.11.1-0.9-1.61.21.21.1-1.3-1.3
Locomotion in novel chamber post-restriction2.13.55.31.7-1.7-1.9-1.72.1-2.11.6-2.1-2.31.71.71.3-2.0-2.0
Fecal boli incidents, locomotor time 11.62.34.1-1.41.51.31.5-1.41.4-1.61.31.4-1.5-1.6-2.01.51.5
Change in fecal boli incidents, locomotor task2.12.13.31.3-1.3-1.3-1.41.6-1.61.5-1.3-1.31.41.51.8-1.5-1.4
Time >=10cm from walls, locomotor time 10.10.10.30.4-0.4-0.4-0.40.3-0.30.4-0.2-0.10.40.50.5-0.4-0.3
Bouts of movement, locomotor time 11.61.82.1-1.41.41.41.4-1.11.1-1.31.41.4-1.3-1.3-1.11.41.4
Total resting periods, locomotor time 12.42.73.0-1.71.71.71.7-1.61.6-1.61.71.7-1.6-1.6-1.41.71.7
Rest time, locomotor task time 10.60.81.11.0-1.0-0.8-0.90.6-0.61.0-0.7-0.80.91.01.1-0.8-0.8
Distance moved, locomotor task time 10.00.00.2-0.10.10.10.10.2-0.2-0.1-0.00.4-0.1-0.1-0.20.30.3
Vertical activity count, locomotor time 10.00.10.40.3-0.3-0.2-0.30.6-0.60.4-0.10.00.30.30.40.10.1
Time >=10cm from walls, locomotor time 20.40.61.4-0.50.50.70.6-0.70.7-0.41.21.0-0.6-0.6-0.41.11.1
Bouts of movement, locomotor time 20.00.00.1-0.10.10.10.2-0.00.0-0.20.2-0.1-0.3-0.3-0.3-0.0-0.0
Total resting periods, locomotor time 20.00.00.20.1-0.1-0.2-0.10.2-0.2-0.0-0.0-0.4-0.1-0.2-0.2-0.3-0.3
Rest time, locomotor task time 21.82.33.31.6-1.5-1.7-1.61.3-1.31.4-1.6-1.61.51.51.2-1.8-1.8
Distance moved, locomotor task time 20.40.51.5-0.50.40.70.5-0.60.6-0.30.81.2-0.4-0.4-0.41.21.2
Vertical activity count, locomotor time 20.10.20.50.5-0.5-0.2-0.40.2-0.20.60.00.20.50.50.70.30.3
Light reinforcement 10.20.50.80.6-0.6-0.5-0.60.9-0.90.7-0.5-0.80.60.60.9-0.7-0.6
Light reinforcement 20.00.00.10.3-0.3-0.2-0.30.2-0.20.30.00.00.30.30.3-0.00.0
Bone: marrow area0.81.82.5-1.41.41.41.4-1.31.3-1.31.11.5-1.3-1.2-1.01.61.6
Bone: maximum diameter1.12.12.6-1.41.41.31.4-1.41.4-1.51.21.6-1.4-1.5-1.61.51.4
Bone: maximum force1.01.82.5-1.21.21.21.2-1.41.4-1.21.41.5-1.3-1.3-1.61.51.5
Bone: maximum moment0.40.71.0-0.70.70.70.7-0.80.8-0.70.90.9-0.8-0.8-1.01.01.0
Mean time between licks in bursts0.61.42.5-1.11.11.01.2-1.21.2-1.31.01.0-1.2-1.3-1.61.11.1
Mean num. licks in bursts2.33.64.8-2.22.22.22.1-1.81.8-2.01.61.8-2.0-1.8-1.41.91.9
Cd content in liver0.10.20.60.3-0.3-0.2-0.30.6-0.60.4-0.2-0.30.30.40.8-0.3-0.3
Co content in liver1.01.22.21.1-1.1-1.0-1.11.0-1.01.2-1.0-1.11.11.21.5-0.9-0.9
Cu content in liver0.50.60.90.8-0.7-0.9-0.70.8-0.80.7-0.9-0.80.70.70.5-0.8-0.8
Fe content in liver0.30.30.5-0.60.60.60.5-0.70.7-0.50.60.5-0.5-0.5-0.40.50.5
K content in liver0.20.20.30.4-0.4-0.5-0.40.4-0.40.4-0.6-0.50.40.50.4-0.4-0.4
Mg content in liver0.40.40.9-0.70.70.50.7-0.60.6-0.80.30.6-0.7-0.7-0.90.60.6
Mn content in liver0.60.70.8-0.90.90.80.8-0.90.9-0.80.70.8-0.8-0.8-0.70.90.9
Na content in liver0.50.50.70.7-0.7-0.7-0.70.4-0.40.7-0.8-0.70.70.80.7-0.8-0.8
Rb content in liver0.20.20.5-0.40.40.30.4-0.40.4-0.50.20.7-0.4-0.4-0.70.70.7
Se content in liver2.32.72.8-1.61.61.61.6-1.71.7-1.61.71.6-1.6-1.6-1.61.61.6
Sr content in liver0.20.20.5-0.50.50.60.5-0.40.4-0.40.70.2-0.5-0.4-0.10.40.4
Zn content in liver0.40.40.9-0.70.80.50.7-0.40.4-0.90.20.4-0.7-0.8-0.90.40.4
Bone: minimum diameter2.54.55.1-2.12.12.12.1-2.12.1-2.12.02.3-2.1-2.1-2.22.22.2
Time in familiar zone, hab. session 11.00.92.21.0-1.1-0.8-1.00.8-0.81.2-0.7-0.71.11.21.5-0.6-0.6
Time in novel zone, hab. session 10.80.82.3-0.80.90.60.9-0.70.7-1.10.60.7-1.0-1.1-1.50.60.6
Total zone transitions, hab. session 10.00.10.3-0.10.10.10.1-0.20.2-0.2-0.00.5-0.1-0.2-0.40.40.4
Total locomotion distance, hab. session 10.10.10.40.2-0.2-0.2-0.20.3-0.30.2-0.6-0.10.20.20.2-0.2-0.2
Locomotion velocity, hab. session 10.10.20.70.3-0.3-0.4-0.30.5-0.50.3-0.9-0.30.40.40.3-0.5-0.4
Time in familiar zone, hab. session 21.11.13.10.9-1.0-0.7-1.01.1-1.11.2-0.7-0.91.11.21.8-0.8-0.8
Time in novel zone, hab. session 20.10.10.7-0.20.3-0.00.2-0.30.3-0.40.00.1-0.3-0.4-0.90.00.0
Total zone transitions, hab. session 20.81.01.21.0-1.0-1.0-1.01.0-1.01.0-1.1-0.81.11.11.0-0.9-0.8
Total locomotion distance, hab. session 21.52.02.71.3-1.3-1.3-1.31.5-1.51.4-1.5-1.41.41.41.6-1.4-1.3
Locomotion velocity, hab. session 20.81.11.50.9-1.0-0.9-1.01.1-1.11.0-1.2-0.91.01.11.2-0.9-0.9
Novel to familiar place preference ratio1.01.12.7-1.01.00.81.1-1.01.0-1.20.90.9-1.1-1.2-1.60.90.8
Novelty place preference0.80.92.3-0.91.00.71.0-0.80.8-1.10.80.7-1.0-1.1-1.50.70.7
Time in novel zone, NPP test0.70.71.9-0.80.90.60.9-0.70.7-1.00.70.6-0.9-1.0-1.40.60.6
Total zone transitions, NPP test2.13.13.61.8-1.8-1.9-1.81.9-1.91.7-1.8-1.71.71.71.5-1.8-1.7
Total locomotion distance, NPP test2.23.03.51.7-1.7-1.7-1.71.9-1.91.7-1.8-1.61.71.71.8-1.7-1.7
Locomotion velocity, NPP test2.02.83.51.7-1.7-1.7-1.71.8-1.81.7-1.9-1.51.71.71.7-1.6-1.6
Intraocular pressure0.50.71.2-0.80.80.90.8-0.60.6-0.70.80.9-0.8-0.8-0.71.01.1
Delta distance traveled before/after self-admin0.30.30.5-0.50.50.50.5-0.70.7-0.50.40.6-0.4-0.4-0.50.60.6
Delta ambulatory time before/after self-admin0.81.01.6-0.90.90.90.8-1.31.3-0.80.81.2-0.8-0.7-0.91.21.2
Parametrial fat weight1.22.83.0-1.71.71.71.7-1.71.7-1.71.61.5-1.7-1.7-1.71.61.6
Pavlov. Cond. lever latency0.30.40.70.6-0.5-0.7-0.50.7-0.70.4-0.6-0.90.40.40.2-0.8-0.8
Pavlov. Cond. magazine entry latency1.62.02.7-1.61.61.61.6-1.41.4-1.51.61.2-1.5-1.4-0.91.11.2
Pavlov. Cond. change in total contacts0.30.30.5-0.60.60.70.6-0.70.7-0.50.50.6-0.5-0.4-0.20.50.5
Pavlov. Cond. index score1.41.82.3-1.51.41.51.4-1.31.3-1.31.51.4-1.3-1.2-0.91.31.3
Pavlov. Cond. latency score0.70.91.3-1.01.01.11.0-1.01.0-0.91.11.1-0.9-0.8-0.51.01.0
Pavlov. Cond. lever contacts0.70.81.1-1.00.91.00.9-0.90.9-0.81.11.0-0.9-0.8-0.50.90.9
Pavlov. Cond. magazine entry number1.31.72.41.5-1.5-1.5-1.51.1-1.11.4-1.5-1.11.41.30.8-1.0-1.1
Pavlov. Cond. intertrial magazine entries1.31.62.01.3-1.3-1.4-1.31.2-1.21.3-1.4-1.21.31.31.1-1.2-1.2
Pavlov. Cond. lever-magazine prob. diff.1.82.22.8-1.61.61.71.5-1.51.5-1.41.71.5-1.5-1.4-1.01.41.5
Pavlov. Cond. response bias1.31.62.3-1.51.41.51.4-1.21.2-1.21.51.1-1.3-1.2-0.71.11.2
Pavlov. Cond. lever latency0.70.91.5-1.01.00.91.0-0.80.8-1.11.00.8-1.1-1.1-1.20.70.7
Pavlov. Cond. magazine entry latency0.10.20.3-0.60.60.40.5-0.20.2-0.60.20.1-0.5-0.5-0.30.10.0
Pavlov. Cond. change in total contacts0.10.10.50.3-0.3-0.1-0.30.2-0.20.4-0.2-0.10.30.40.7-0.0-0.0
Pavlov. Cond. index score0.00.00.20.1-0.1-0.1-0.10.1-0.10.2-0.2-0.10.20.20.4-0.1-0.1
Pavlov. Cond. latency score0.00.00.20.1-0.1-0.0-0.10.1-0.10.2-0.1-0.10.10.20.4-0.1-0.1
Pavlov. Cond. lever contacts0.60.81.20.9-0.9-0.8-0.90.8-0.81.0-1.0-0.71.01.01.1-0.7-0.7
Pavlov. Cond. magazine entry number0.00.00.10.0-0.00.10.0-0.20.20.10.20.3-0.0-0.0-0.10.30.3
Pavlov. Cond. intertrial magazine entries0.81.21.7-1.01.01.11.0-1.11.1-0.91.21.2-1.0-1.0-1.01.31.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.20.0-0.1-0.0-0.10.0-0.00.1-0.10.00.10.20.4-0.1-0.1
Pavlov. Cond. response bias0.40.61.00.7-0.7-0.7-0.70.8-0.80.7-1.0-0.80.80.80.8-0.7-0.7
Time in closed arm before self-admin0.50.61.0-1.01.00.80.9-0.50.5-1.00.60.5-0.9-0.9-0.90.60.6
Time in closed arm after self-admin0.60.61.4-0.90.90.70.9-0.20.2-1.00.70.3-1.0-1.1-1.20.50.5
Time in open arm before self-admin1.82.02.41.3-1.3-1.3-1.41.4-1.41.4-1.4-1.41.51.51.6-1.3-1.3
Time in open arm after self-admin1.21.31.81.2-1.2-1.2-1.20.8-0.81.2-1.3-1.01.31.31.2-1.1-1.1
Bone: periosteal estimation1.63.54.2-1.81.81.81.8-1.81.8-1.81.72.0-1.8-1.8-1.92.02.0
Bone: periosteal perimeter0.71.21.8-1.11.11.01.1-1.01.0-1.20.81.1-1.1-1.2-1.41.01.0
Bone: post-yield work1.11.61.9-1.41.41.41.4-1.01.0-1.31.21.2-1.4-1.4-1.21.21.3
Progressive ratio test 1 active lever presses0.30.40.8-0.60.60.70.7-0.50.5-0.70.90.4-0.8-0.8-0.60.40.4
Progressive ratio test 1 breakpoint0.40.51.0-0.70.70.70.7-0.60.6-0.71.00.5-0.8-0.8-0.70.50.5
Progressive ratio test 1 inactive lever presses0.30.40.7-0.70.60.70.7-0.40.4-0.60.90.5-0.7-0.7-0.50.50.5
Progressive ratio test 2 active lever presses2.93.44.2-1.81.81.81.8-1.81.8-1.82.11.9-1.8-1.9-1.91.91.9
Progressive ratio test 2 breakpoint3.03.44.3-1.71.71.81.8-1.81.8-1.82.11.9-1.8-1.9-1.91.91.9
Progressive ratio test 2 inactive lever presses0.60.91.7-0.90.91.01.0-0.80.8-0.91.31.0-1.0-1.1-1.01.01.0
Incentive Sensitization - Responses1.21.72.2-1.21.31.31.3-1.21.2-1.31.31.4-1.2-1.3-1.51.41.4
Incentive Sensitization - Breakpoint1.51.92.4-1.31.31.31.3-1.31.3-1.31.41.5-1.3-1.3-1.51.51.5
Sum of active levers in priming session hrs 5-60.10.10.20.1-0.10.1-0.1-0.10.10.20.10.40.10.20.30.40.4
Progressive ratio0.00.10.10.2-0.2-0.1-0.20.2-0.20.2-0.3-0.30.20.20.3-0.3-0.3
Food seeking constrained by brief footshock1.11.42.01.0-1.0-1.0-1.01.2-1.21.0-1.3-1.41.01.11.3-1.4-1.4
Seeking ratio, punishment vs. effort0.20.30.60.3-0.3-0.5-0.40.7-0.70.3-0.7-0.70.40.40.5-0.8-0.8
Retroperitoneal fat weight0.31.32.4-1.21.21.21.1-1.51.5-1.10.91.2-1.1-1.0-1.01.01.0
Reaction time number correct0.51.02.30.7-0.8-0.8-0.81.5-1.50.8-1.0-1.30.80.80.9-1.0-1.0
Reaction time mean minus median0.92.23.1-1.61.61.41.6-1.41.4-1.71.41.3-1.5-1.6-1.81.31.4
Reaction time mean minus median AUC0.10.20.3-0.40.40.30.4-0.40.4-0.40.30.5-0.3-0.3-0.50.60.6
Reaction time num false alarms0.30.40.8-0.80.80.90.8-0.30.3-0.60.80.2-0.7-0.6-0.10.30.3
Reaction time num false alarms AUC0.00.10.2-0.40.40.40.30.1-0.1-0.30.2-0.2-0.3-0.20.2-0.1-0.1
Reaction time trials correct on left0.51.02.30.7-0.8-0.8-0.81.5-1.50.8-1.0-1.30.80.80.9-1.0-1.0
Reaction time trials on left0.50.92.00.7-0.7-0.8-0.71.4-1.40.7-0.9-1.20.70.70.8-0.9-0.9
Reaction time mean0.20.30.6-0.70.70.50.7-0.30.3-0.80.40.3-0.7-0.8-0.80.30.3
Reaction time mean AUC0.30.50.8-0.70.80.60.7-0.50.5-0.90.50.5-0.8-0.8-0.90.50.5
Median of all reaction times0.00.10.2-0.30.30.10.30.1-0.1-0.40.10.1-0.4-0.4-0.4-0.0-0.0
Reaction time omissions1.01.51.8-1.21.31.11.2-1.31.3-1.31.01.2-1.1-1.1-1.21.31.3
Reaction time false alarm rate0.30.40.8-0.80.80.90.8-0.70.7-0.70.80.5-0.7-0.6-0.30.50.4
Reaction time premature initiation rate2.23.04.5-1.51.51.51.5-2.12.1-1.52.01.9-1.5-1.5-1.61.91.9
Reaction time premature initiations0.61.11.9-1.01.01.01.0-1.11.1-1.01.41.1-1.0-1.0-1.01.21.2
Std. dev. reaction times0.91.62.0-1.41.41.21.3-1.21.2-1.41.11.1-1.3-1.3-1.41.21.2
Reaction time trials completed0.50.92.00.7-0.7-0.8-0.71.4-1.40.7-0.9-1.20.70.70.8-0.9-0.9
Reaction time trials AUC0.40.82.10.6-0.6-0.7-0.61.5-1.50.6-0.9-1.20.60.60.8-0.9-0.9
Run reversals in cocaine runway, females1.61.62.71.3-1.3-1.2-1.30.8-0.81.3-1.1-1.11.31.31.5-1.6-1.6
Run reversals in cocaine runway, males0.80.81.60.8-0.8-0.9-0.80.8-0.80.8-1.3-1.00.80.80.7-1.0-1.0
Latency to leave start box in cocaine runway0.00.00.2-0.10.1-0.00.1-0.20.2-0.20.10.1-0.1-0.1-0.40.20.2
Latency to leave start box in cocaine runway, F0.50.61.2-0.80.80.60.8-0.80.8-0.90.60.7-0.8-0.8-1.10.70.7
Latency to leave start box in cocaine runway, M0.90.81.01.0-1.0-0.9-1.00.8-0.81.0-0.9-0.91.01.00.9-0.8-0.8
Std. dev. time between licks in bursts1.21.62.11.5-1.5-1.4-1.40.9-0.91.4-1.3-1.01.41.41.2-1.1-1.1
Total sessions with >9 infusions0.70.81.0-0.90.90.80.9-0.90.9-0.91.00.8-0.9-0.9-1.00.90.9
Short access day 1 total inactive lever presses0.40.50.9-0.70.70.60.7-0.90.9-0.70.70.5-0.6-0.7-0.80.60.6
Short access day 10 total inactive lever presses0.00.10.20.3-0.3-0.3-0.30.4-0.40.4-0.2-0.20.40.40.5-0.2-0.2
Short access day 1 total infusions1.11.51.9-1.21.21.21.2-1.01.0-1.21.41.3-1.2-1.2-1.31.31.3
Short access day 10 total infusions1.21.62.3-1.21.21.21.2-1.31.3-1.31.21.1-1.2-1.3-1.51.21.2
Short access total infusions1.41.82.3-1.21.21.31.3-1.41.4-1.31.51.4-1.2-1.3-1.41.51.5
Short access day 1 locomotion0.00.10.1-0.20.20.30.2-0.20.2-0.20.40.2-0.2-0.2-0.20.30.3
Short access day 10 total locomotion0.00.00.10.1-0.1-0.2-0.1-0.30.30.1-0.2-0.30.20.20.1-0.3-0.3
Short access total locomotion0.00.00.2-0.00.00.10.1-0.50.5-0.00.20.0-0.0-0.1-0.10.10.1
One hour access (0.3 mA shock)2.12.42.8-1.51.51.51.5-1.61.6-1.51.41.6-1.4-1.4-1.71.71.7
Compulsive drug intake0.10.10.20.2-0.2-0.2-0.3-0.20.20.2-0.50.00.40.50.10.20.2
One hour access (shock baseline)1.01.51.8-1.31.31.31.3-1.01.0-1.31.31.1-1.3-1.3-1.31.01.0
Social response proportion1.31.52.3-1.01.01.11.1-1.41.4-1.01.21.4-1.0-1.0-1.21.51.5
Social responses0.10.10.20.3-0.3-0.1-0.2-0.20.20.30.10.30.30.30.20.40.4
Social time0.81.11.81.0-1.0-1.0-1.11.1-1.11.1-0.7-0.91.11.21.3-0.8-0.8
Soleus weight0.10.40.90.5-0.5-0.5-0.60.6-0.60.6-0.8-0.50.60.70.9-0.6-0.6
Bone: stiffness3.04.86.1-2.02.02.12.1-2.32.3-2.12.52.1-2.1-2.2-2.32.22.3
Tibialis anterior weight0.10.20.3-0.50.50.50.5-0.30.3-0.50.60.2-0.5-0.5-0.40.30.2
Time to tail flick, vehicle, before self-admin0.40.40.60.7-0.7-0.7-0.70.7-0.70.7-0.8-0.60.70.70.6-0.6-0.6
Time to tail flick, vehicle, after self-admin0.20.20.50.6-0.6-0.5-0.6-0.00.00.7-0.3-0.10.60.70.6-0.1-0.1
Time to tail flick, test, before self-admin1.81.92.21.4-1.4-1.4-1.41.1-1.11.4-1.4-1.31.51.51.3-1.4-1.4
Time to tail flick, test, after self-admin2.22.33.71.6-1.5-1.6-1.61.2-1.21.6-1.9-1.21.71.81.5-1.3-1.3
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.30.20.40.3-0.70.7-0.20.70.5-0.2-0.2-0.20.60.6
Delta time to tail flick, test, before/after SA0.10.10.20.2-0.2-0.2-0.20.3-0.30.2-0.5-0.10.20.20.2-0.3-0.3
Tibia length2.05.66.3-2.42.42.52.4-2.42.4-2.32.52.3-2.4-2.3-2.02.32.4
Ambulatory time before self-admin0.20.30.80.5-0.6-0.3-0.50.6-0.60.7-0.2-0.40.50.60.9-0.2-0.2
Ambulatory time after self-admin0.40.40.9-0.60.50.70.5-0.80.8-0.40.70.9-0.4-0.3-0.10.90.9
Bone: tissue strength0.10.10.10.4-0.4-0.3-0.30.4-0.40.4-0.2-0.20.30.30.2-0.2-0.2
Total heroin consumption0.10.10.2-0.30.40.10.3-0.20.2-0.4-0.40.1-0.2-0.2-0.5-0.1-0.1
Bone: trabecular number0.10.20.30.5-0.5-0.4-0.50.5-0.50.5-0.5-0.60.50.50.4-0.4-0.4
Bone: trabecular spacing0.10.10.20.2-0.2-0.3-0.20.3-0.30.2-0.2-0.30.20.20.3-0.4-0.5
Bone: trabecular thickness0.10.20.30.4-0.4-0.5-0.40.6-0.60.3-0.4-0.40.30.30.1-0.4-0.4
Bone: trabecular tissue density0.10.10.4-0.10.10.20.2-0.20.2-0.10.60.3-0.2-0.3-0.30.30.4
Water consumed over 24 hours0.00.00.1-0.10.10.20.10.1-0.10.0-0.20.10.00.10.4-0.0-0.0
Number of responses in last shaping day0.91.01.80.9-1.0-0.8-0.91.3-1.31.0-0.5-1.00.80.71.1-1.0-1.0