Hub : Genes

Mapre3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Mapre3 0.07 0.06 1.6e-03 0.02 0.01 0.01 0.01 1.4e-03 2.1e-02 6.1e-03 2.8e-03
2 IC gene expression Mapre3 0.06 0.05 3.2e-03 0.07 0.05 0.06 0.06 9.1e-04 4.0e-03 1.7e-03 1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.93.53.5-1.9-1.9
Area under the delay curve0.00.10.1-0.4-0.0
BMI with tail1.24.17.42.70.9
BMI without tail0.84.16.62.61.3
Body weight2.711.813.83.73.1
Weight adjusted by age0.00.10.3-0.0-0.5
Bone surface0.30.50.5-0.7-0.7
Bone volume0.50.91.3-1.1-0.8
Breakpoint value in progressive ratio session0.20.30.5-0.4-0.7
Number of licking bursts0.20.71.21.10.4
Context. condit. distance diff. score0.10.10.2-0.5-0.3
Locomotion velocity, session 10.40.50.70.40.9
Locomotion distance, session 10.40.50.9-1.0-0.3
Locomotion velocity, session 20.20.20.20.40.4
Locomotion distance, session 20.10.10.10.10.4
Locomotion velocity, session 30.70.91.5-0.5-1.2
Locomotion distance, session 30.10.10.2-0.2-0.5
Stereotopy head waving bouts, day 32.02.33.2-1.2-1.8
Stereotopy head waving duration, day 30.30.30.5-0.3-0.7
Locomotion velocity, session 70.10.10.20.2-0.5
Locomotion distance, session 70.50.61.01.00.5
Stereotopy head waving bouts, day 70.10.10.20.4-0.3
Stereotopy head waving duration, day 70.60.81.2-0.6-1.1
Locomotion velocity, session 80.30.40.4-0.6-0.6
Locomotion distance, session 80.20.30.4-0.6-0.4
Degree of sensitization distance1.51.61.71.31.2
Degree of sensitization stereotypy0.30.30.70.80.1
Conditioned locomotion4.04.75.0-2.2-2.1
Cocaine response after cond. corrected0.10.10.1-0.4-0.1
Cocaine response after cond. not corrected0.50.81.0-1.0-0.7
Cocaine response before conditioning3.23.83.9-1.9-2.0
Saline control response1.01.42.0-0.9-1.4
Bone: connectivity density1.52.42.8-1.4-1.7
Bone: cortical apparent density0.10.10.2-0.3-0.4
Bone: cortical area0.00.00.10.20.2
Bone: cortical porosity3.03.33.8-2.0-1.7
Bone: cortical porosity2.32.53.1-1.8-1.4
Bone: cortical thickness0.20.40.40.60.6
Bone: cortical thickness0.40.40.5-0.7-0.6
Bone: cortical tissue density0.00.10.1-0.2-0.3
Condit. Reinf. active minus inactive responses1.51.71.71.31.3
Condit. Reinf. active-inactive response ratio1.51.61.61.21.3
Condit. Reinf. active responses0.00.00.0-0.00.1
Condit. Reinf. inactive responses1.11.51.5-1.2-1.2
Incentive salience index mean0.20.20.30.40.5
Condit. Reinf. lever presses0.40.50.9-0.9-0.5
Condit. Reinf. active minus inactive responses4.46.78.6-2.2-2.9
Condit. Reinf. active-inactive response ratio2.03.24.4-1.4-2.1
Condit. Reinf. active responses3.34.76.1-1.8-2.5
Condit. Reinf. inactive responses0.30.50.6-0.6-0.8
Condit. Reinf. lever presses2.63.74.1-1.8-2.0
Condit. Reinf. lever reinforcers received3.24.56.0-1.7-2.5
Conditioned reinforcement - actives1.66.58.6-2.9-2.1
Conditioned reinforcement - inactives1.64.44.5-2.1-2.1
Conditioned locomotion1.42.12.6-1.6-1.3
Patch foraging indifference point 0 sec0.41.01.41.20.8
Patch foraging indifference point AUC0.00.10.2-0.1-0.4
Delay disc. indifference point, 0s delay2.62.95.00.92.2
Delay disc. indifference point, 16s delay0.10.20.2-0.5-0.4
Delay disc. indifference point, 2s delay0.20.30.50.20.7
Delay disc. indifference point, 24s delay0.91.52.5-1.6-0.7
Delay disc. indifference point, 4s delay0.00.00.10.20.2
Delay disc. indifference point, 8s delay0.00.10.1-0.3-0.0
Indifference point function ln k0.30.91.2-1.1-0.7
Indifference point function log k0.30.91.2-1.1-0.7
Patch foraging total patch changes 0 sec0.41.11.81.30.7
Patch foraging total patch changes 12 sec1.72.22.61.61.4
Patch foraging total patch changes 18 sec0.51.22.11.50.4
Patch foraging total patch changes 24 sec0.31.21.61.30.9
Patch foraging total patch changes 6 sec0.91.52.31.50.9
Patch foraging time to switch 0 sec0.10.40.70.90.1
Patch foraging water rate 0 sec0.20.60.9-0.9-0.5
Patch foraging water rate 12 sec0.10.20.40.20.7
Patch foraging water rate 18 sec0.10.30.5-0.70.2
Patch foraging water rate 24 sec0.71.01.01.01.0
Patch foraging water rate 6 sec0.20.30.5-0.20.7
Seeking ratio, delayed vs. immediate footshock0.00.00.00.0-0.0
Distance traveled before self-admin0.10.30.6-0.80.1
Distance traveled after self-admin1.42.43.51.21.9
Extensor digitorum longus weight3.514.117.4-3.3-4.2
Bone: elastic displacement1.51.92.7-1.7-1.0
Bone: elastic work0.70.91.4-1.2-0.7
Bone: endosteal estimation0.00.00.0-0.1-0.0
Bone: endosteal perimeter0.00.00.00.00.2
Epididymis fat weight10.251.357.17.66.7
Delta time in closed arm before/after self-admin0.50.40.90.90.1
Delta time in open arm before/after self-admin0.10.10.2-0.0-0.4
Diff in mean of infusions in LGA sessions0.10.10.20.4-0.2
Delay discount exponential model param0.20.20.40.60.3
Extinction: sum of active levers before priming0.20.30.50.2-0.7
Active lever presses in extinction session 60.90.91.1-0.8-1.0
Bone: final force0.10.10.10.20.4
Bone: final moment0.10.10.20.10.4
Food consumed during 24 hour testing period0.00.10.1-0.0-0.3
Glucose0.40.70.80.90.8
Heart weight2.74.45.31.82.3
Delay discount hyperbolic model param0.00.10.10.30.1
Intermittent access intake day 1-15 change0.10.40.5-0.7-0.6
Intermittent access intake escalation0.00.10.2-0.4-0.2
Intermittent access intake escalation 20.00.00.00.1-0.1
Intermitt. access day 1 inactive lever presses0.22.02.6-1.2-1.6
Intermitt. access day 15 inactive lever presses0.74.05.8-1.5-2.4
Intermitt. access escalation Index1.34.07.12.70.9
Intermittent access day 1 total infusions2.16.46.8-2.6-2.5
Intermittent access day 15 total infusions1.43.54.1-2.0-1.7
Intermittent access terminal intake (last 3 days)2.95.16.0-2.5-2.1
Intermittent access total infusions4.65.56.8-2.6-2.0
Intermittent access day 1 locomotion1.83.43.6-1.8-1.9
Intermittent access day 15 total locomotion0.20.81.2-0.6-1.1
Intermittent access total locomotion1.21.41.8-1.0-1.3
Intermittent access standard deviation0.42.32.3-1.5-1.5
Left kidney weight0.00.00.00.00.2
Right kidney weight0.21.72.31.11.5
Cocaine induced anxiety0.10.20.30.3-0.5
Post-drug Anxiety1.71.92.21.51.3
Baseline Anxiety1.83.04.21.42.1
Tail length0.20.91.70.41.3
Length with tail1.04.46.71.42.6
Length without tail0.31.72.41.01.6
Times rat made contact with spout1.01.11.7-0.7-1.3
Lifetime Intake4.55.66.4-2.5-2.2
Liver weight, left3.56.18.02.02.8
Liver weight, right7.112.313.63.33.7
Locomotor activity0.60.91.51.20.6
Locomotor testing distance0.10.30.50.7-0.4
Locomotor testing rearing0.31.11.9-0.5-1.4
Locomotion in novel chamber0.00.10.10.3-0.2
Locomotion in novel chamber post-restriction1.44.25.32.31.8
Fecal boli incidents, locomotor time 10.30.71.0-1.0-0.7
Change in fecal boli incidents, locomotor task4.34.55.02.02.2
Time >=10cm from walls, locomotor time 10.10.10.3-0.50.1
Bouts of movement, locomotor time 10.60.71.4-0.3-1.2
Total resting periods, locomotor time 10.70.81.5-0.4-1.2
Rest time, locomotor task time 10.00.10.1-0.10.3
Distance moved, locomotor task time 10.30.81.01.00.8
Vertical activity count, locomotor time 10.00.30.40.50.6
Time >=10cm from walls, locomotor time 20.51.32.2-1.5-0.6
Bouts of movement, locomotor time 20.10.30.30.50.5
Total resting periods, locomotor time 20.00.10.10.40.2
Rest time, locomotor task time 20.30.60.8-0.6-0.9
Distance moved, locomotor task time 20.20.30.40.40.6
Vertical activity count, locomotor time 20.10.20.30.00.6
Light reinforcement 10.52.23.6-0.9-1.9
Light reinforcement 20.81.81.9-1.3-1.4
Bone: marrow area0.00.00.0-0.1-0.1
Bone: maximum diameter0.00.00.10.3-0.0
Bone: maximum force0.00.00.0-0.20.0
Bone: maximum moment0.00.00.1-0.30.1
Mean time between licks in bursts0.63.33.71.71.9
Mean num. licks in bursts0.30.91.3-1.1-0.7
Cd content in liver0.10.10.20.40.1
Co content in liver4.85.66.3-2.5-2.2
Cu content in liver0.50.60.9-1.0-0.5
Fe content in liver1.61.92.4-1.6-1.2
K content in liver0.30.30.50.40.7
Mg content in liver0.30.40.50.50.7
Mn content in liver0.70.81.41.20.4
Na content in liver1.31.52.7-1.6-0.5
Rb content in liver0.50.50.60.80.7
Se content in liver0.10.10.20.40.1
Sr content in liver0.20.20.3-0.50.3
Zn content in liver1.21.42.40.51.6
Bone: minimum diameter0.81.61.71.21.3
Time in familiar zone, hab. session 11.41.51.61.31.2
Time in novel zone, hab. session 10.10.10.20.40.0
Total zone transitions, hab. session 10.10.20.3-0.3-0.5
Total locomotion distance, hab. session 10.10.10.1-0.4-0.2
Locomotion velocity, hab. session 10.60.91.2-1.1-0.8
Time in familiar zone, hab. session 20.10.10.20.5-0.2
Time in novel zone, hab. session 20.40.50.90.21.0
Total zone transitions, hab. session 20.10.10.20.40.4
Total locomotion distance, hab. session 20.00.00.00.10.1
Locomotion velocity, hab. session 20.00.00.0-0.1-0.1
Novel to familiar place preference ratio1.11.51.61.21.3
Novelty place preference1.62.02.11.41.5
Time in novel zone, NPP test1.62.02.01.41.4
Total zone transitions, NPP test1.11.61.7-1.3-1.2
Total locomotion distance, NPP test1.31.91.9-1.4-1.4
Locomotion velocity, NPP test1.92.72.7-1.7-1.6
Intraocular pressure6.310.411.63.43.0
Delta distance traveled before/after self-admin2.32.63.11.81.4
Delta ambulatory time before/after self-admin0.61.01.41.20.8
Parametrial fat weight13.632.033.55.85.5
Pavlov. Cond. lever latency0.70.90.91.00.9
Pavlov. Cond. magazine entry latency0.00.00.00.10.1
Pavlov. Cond. change in total contacts0.00.00.0-0.20.1
Pavlov. Cond. index score0.00.10.1-0.2-0.3
Pavlov. Cond. latency score0.00.00.1-0.1-0.3
Pavlov. Cond. lever contacts0.40.50.7-0.8-0.6
Pavlov. Cond. magazine entry number0.00.00.10.20.2
Pavlov. Cond. intertrial magazine entries2.42.93.0-1.7-1.7
Pavlov. Cond. lever-magazine prob. diff.0.30.40.4-0.6-0.7
Pavlov. Cond. response bias0.60.80.9-0.9-0.8
Pavlov. Cond. lever latency1.82.52.81.51.7
Pavlov. Cond. magazine entry latency0.20.30.3-0.5-0.6
Pavlov. Cond. change in total contacts0.51.21.8-0.8-1.3
Pavlov. Cond. index score1.22.02.2-1.3-1.5
Pavlov. Cond. latency score1.32.12.3-1.4-1.5
Pavlov. Cond. lever contacts1.21.82.0-1.2-1.4
Pavlov. Cond. magazine entry number0.10.20.30.30.5
Pavlov. Cond. intertrial magazine entries2.45.15.62.22.4
Pavlov. Cond. lever-magazine prob. diff.0.71.21.4-1.0-1.2
Pavlov. Cond. response bias1.92.62.9-1.5-1.7
Time in closed arm before self-admin0.20.40.70.80.4
Time in closed arm after self-admin0.91.01.71.30.6
Time in open arm before self-admin0.00.00.00.0-0.1
Time in open arm after self-admin0.50.61.0-0.4-1.0
Bone: periosteal estimation0.00.00.0-0.1-0.1
Bone: periosteal perimeter0.00.00.0-0.00.1
Bone: post-yield work1.32.32.3-1.5-1.5
Progressive ratio test 1 active lever presses1.83.23.9-2.0-1.6
Progressive ratio test 1 breakpoint1.83.23.8-2.0-1.6
Progressive ratio test 1 inactive lever presses2.36.16.3-2.4-2.5
Progressive ratio test 2 active lever presses1.42.03.1-1.8-0.9
Progressive ratio test 2 breakpoint1.31.72.8-1.7-0.8
Progressive ratio test 2 inactive lever presses1.03.33.6-1.9-1.7
Incentive Sensitization - Responses0.30.71.2-1.1-0.5
Incentive Sensitization - Breakpoint0.20.40.8-0.9-0.3
Sum of active levers in priming session hrs 5-60.40.40.70.9-0.1
Progressive ratio0.00.00.00.20.1
Food seeking constrained by brief footshock5.56.98.1-2.8-2.4
Seeking ratio, punishment vs. effort0.40.81.2-1.1-0.6
Retroperitoneal fat weight24.9111.4130.911.49.6
Reaction time number correct0.10.50.5-0.7-0.7
Reaction time mean minus median0.00.30.3-0.6-0.6
Reaction time mean minus median AUC0.00.00.0-0.1-0.1
Reaction time num false alarms1.11.82.91.70.8
Reaction time num false alarms AUC0.81.82.91.70.8
Reaction time trials correct on left0.10.50.5-0.7-0.7
Reaction time trials on left0.10.50.6-0.6-0.7
Reaction time mean0.30.71.30.41.1
Reaction time mean AUC0.30.61.10.41.1
Median of all reaction times0.71.11.80.61.4
Reaction time omissions0.10.20.50.7-0.1
Reaction time false alarm rate1.72.43.41.81.2
Reaction time premature initiation rate0.00.00.00.00.2
Reaction time premature initiations0.00.10.1-0.2-0.2
Std. dev. reaction times0.00.10.20.10.4
Reaction time trials completed0.10.50.6-0.6-0.7
Reaction time trials AUC0.20.70.9-0.8-0.9
Run reversals in cocaine runway, females0.40.40.8-0.90.1
Run reversals in cocaine runway, males0.40.40.7-0.9-0.3
Latency to leave start box in cocaine runway1.01.42.2-1.5-0.8
Latency to leave start box in cocaine runway, F0.30.40.5-0.7-0.5
Latency to leave start box in cocaine runway, M1.00.91.8-1.3-0.2
Std. dev. time between licks in bursts0.81.42.31.50.7
Total sessions with >9 infusions1.92.42.8-1.7-1.4
Short access day 1 total inactive lever presses3.06.07.9-2.0-2.8
Short access day 10 total inactive lever presses0.42.84.1-1.3-2.0
Short access day 1 total infusions2.95.86.6-2.2-2.6
Short access day 10 total infusions2.84.65.8-2.4-1.9
Short access total infusions2.02.82.9-1.6-1.7
Short access day 1 locomotion3.15.15.6-2.2-2.4
Short access day 10 total locomotion0.72.73.0-1.5-1.7
Short access total locomotion0.50.80.9-0.9-0.9
One hour access (0.3 mA shock)2.73.24.3-2.1-1.4
Compulsive drug intake2.03.04.02.01.4
One hour access (shock baseline)2.25.88.0-2.8-1.9
Social response proportion0.40.50.8-0.30.9
Social responses0.20.30.5-0.00.7
Social time0.10.10.2-0.00.4
Soleus weight3.911.412.7-3.2-3.6
Bone: stiffness0.00.00.00.2-0.1
Tibialis anterior weight2.48.310.3-2.5-3.2
Time to tail flick, vehicle, before self-admin0.20.20.40.30.6
Time to tail flick, vehicle, after self-admin1.53.03.41.61.8
Time to tail flick, test, before self-admin0.10.10.20.1-0.4
Time to tail flick, test, after self-admin0.40.40.5-0.7-0.5
Delta time to tail flick, vehicle, before/after SA0.20.20.40.60.3
Delta time to tail flick, test, before/after SA1.51.92.4-1.6-1.2
Tibia length3.18.510.22.63.2
Ambulatory time before self-admin0.10.30.6-0.8-0.2
Ambulatory time after self-admin0.81.32.00.81.4
Bone: tissue strength0.60.60.90.51.0
Total heroin consumption1.82.12.8-1.2-1.7
Bone: trabecular number1.22.33.0-1.7-1.2
Bone: trabecular spacing0.91.31.71.31.0
Bone: trabecular thickness0.10.10.3-0.50.0
Bone: trabecular tissue density0.40.60.8-0.7-0.9
Water consumed over 24 hours0.00.00.10.1-0.3
Number of responses in last shaping day0.20.20.3-0.5-0.4