Hub : Genes

Mapk6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Mapk6	0.27	0.09	0.0e+00	0.13	0.21	0.22	0.21	5.8e-14	2.3e-23	1.7e-23	5.9e-23
2	Brain	gene expression	Mapk6	0.06	0.04	1.8e-04	0.03	0.04	0.04	0.04	5.3e-04	1.4e-04	1.9e-04	5.9e-05
3	Liver	gene expression	Mapk6	0.07	0.04	1.5e-03	0	0	-0	-0	1.9e-01	3.4e-01	9.2e-01	7.3e-01
4	PL	gene expression	Mapk6	0.04	0.02	9.3e-06	0.04	0.05	0.04	0.04	2.7e-05	3.4e-06	2.2e-05	1.5e-05
5	Adipose	intron excision ratio	chr8_85039293_85049434	0.04	0.03	6.5e-04	0.01	0.01	0	0	1.7e-02	1.8e-02	3.3e-01	1.0e-01
6	Adipose	mRNA stability	Mapk6	0.05	0.03	2.0e-03	0	0.01	0	0	1.4e-01	1.7e-02	2.5e-01	8.6e-02
7	NAcc	gene expression	Mapk6	0.13	0.06	1.2e-09	0.04	0.07	0.07	0.07	3.6e-07	1.7e-10	2.7e-10	1.3e-10
8	Brain	mRNA stability	Mapk6	0.04	0.03	5.0e-03	0	0.01	0	0.01	3.2e-01	4.2e-02	1.6e-01	7.9e-02
9	Adipose	intron excision ratio	chr8_85039293_85050092	0.04	0.02	7.8e-04	0.01	0.01	0	0	2.3e-02	2.0e-02	3.6e-01	1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.1	0.1	0.4	-0.2	-0.0	0.3	0.2	0.3	0.4	-0.2	-0.6	-0.7
Area under the delay curve	0.5	0.6	2.6	0.2	1.6	-0.6	0.7	0.3	-0.5	1.0	0.3	-0.1
BMI with tail	1.1	3.7	13.5	1.3	3.7	-2.3	1.4	-0.1	-1.5	2.4	1.4	0.8
BMI without tail	0.6	1.8	6.9	-0.3	2.6	-1.5	0.5	-0.5	-1.6	1.6	1.2	0.4
Body weight	1.2	5.3	13.3	0.1	3.6	-2.9	0.6	-1.2	-2.9	2.2	2.7	1.9
Weight adjusted by age	0.7	1.1	4.3	0.1	1.7	-2.1	1.6	-0.2	-0.5	-0.3	0.1	0.0
Bone surface	1.0	1.9	4.3	1.1	1.6	-0.4	2.1	1.3	1.2	0.3	-1.6	-1.8
Bone volume	0.4	0.7	1.6	0.5	1.3	-0.4	1.3	0.8	0.5	0.4	-0.8	-1.1
Breakpoint value in progressive ratio session	0.6	0.7	2.2	0.6	1.1	-1.0	1.5	0.3	0.6	-0.4	-0.8	-0.8
Number of licking bursts	0.7	1.1	3.8	0.8	1.5	-1.3	1.9	0.3	0.5	-0.2	-0.7	-0.8
Context. condit. distance diff. score	0.4	0.5	1.5	1.2	0.1	-0.4	1.0	0.6	0.7	0.1	-0.6	-0.4
Locomotion velocity, session 1	0.3	0.3	1.2	0.2	1.1	-0.2	0.1	0.2	-0.5	1.1	0.4	-0.1
Locomotion distance, session 1	0.4	0.5	2.9	-1.7	-0.2	0.3	-0.2	-0.4	-0.3	-0.8	-0.2	-0.6
Locomotion velocity, session 2	0.4	0.5	1.9	0.2	1.4	-0.1	0.7	0.5	-0.0	1.1	-0.3	-0.7
Locomotion distance, session 2	0.5	0.7	3.5	-1.9	0.8	0.2	-0.5	-0.5	-1.1	0.5	0.4	-0.4
Locomotion velocity, session 3	2.3	2.6	6.6	0.6	-0.0	1.3	1.2	1.8	2.1	0.1	-2.4	-2.6
Locomotion distance, session 3	1.6	1.8	4.8	-0.5	-1.0	2.2	-0.4	1.1	1.5	-0.2	-1.7	-1.8
Stereotopy head waving bouts, day 3	0.8	1.0	2.1	1.1	-1.2	-0.3	0.9	0.3	1.4	-1.5	-1.1	-0.3
Stereotopy head waving duration, day 3	0.7	0.9	3.1	1.8	-0.9	-0.4	0.9	0.6	1.3	-0.7	-0.8	-0.0
Locomotion velocity, session 7	0.1	0.1	0.2	-0.2	-0.4	0.2	0.1	0.1	0.3	-0.5	-0.4	-0.4
Locomotion distance, session 7	0.1	0.2	0.6	-0.0	0.5	0.2	0.4	0.3	0.3	-0.1	-0.6	-0.8
Stereotopy head waving bouts, day 7	2.8	3.2	5.8	1.8	-0.3	1.4	1.3	2.2	2.4	0.2	-2.4	-2.3
Stereotopy head waving duration, day 7	2.8	3.4	5.8	1.8	-0.0	1.5	1.2	2.4	2.3	0.5	-2.4	-2.4
Locomotion velocity, session 8	1.5	1.8	4.0	0.9	1.0	1.0	0.9	1.8	1.2	1.3	-1.5	-2.0
Locomotion distance, session 8	0.3	0.5	1.7	-0.3	0.8	-0.1	0.9	0.5	0.3	0.1	-0.8	-1.3
Degree of sensitization distance	1.0	1.1	3.4	0.2	1.1	-1.8	0.6	-0.9	-1.1	-0.1	1.1	1.2
Degree of sensitization stereotypy	2.4	2.7	4.9	1.5	0.1	1.4	1.1	2.1	2.0	0.4	-2.2	-2.2
Conditioned locomotion	2.1	2.4	3.8	-1.9	-0.4	-1.2	-1.2	-2.0	-2.0	-0.7	1.9	1.9
Cocaine response after cond. corrected	0.9	1.0	4.0	2.0	1.1	-0.5	1.3	0.9	0.6	1.0	-0.4	-0.4
Cocaine response after cond. not corrected	1.0	1.1	4.0	2.0	1.2	-1.3	1.3	0.4	0.0	1.0	0.2	0.4
Cocaine response before conditioning	1.0	1.2	4.0	0.1	1.3	-2.0	0.6	-0.8	-1.2	0.4	1.2	1.1
Saline control response	1.4	1.8	4.3	1.6	-1.4	1.1	0.6	1.2	2.1	-0.8	-1.7	-1.0
Bone: connectivity density	0.5	0.7	1.7	-1.3	-0.9	0.9	-0.2	0.0	0.6	-1.0	-1.0	-1.0
Bone: cortical apparent density	0.9	1.3	4.0	-0.4	-2.0	1.6	-2.0	-0.0	-0.1	0.3	0.5	0.8
Bone: cortical area	0.3	0.5	1.3	1.2	-0.6	-0.4	0.7	0.3	1.0	-0.8	-0.6	0.2
Bone: cortical porosity	0.9	1.0	2.6	-1.1	-0.8	-1.2	-0.2	-1.4	-0.4	-1.6	0.5	0.9
Bone: cortical porosity	0.9	0.9	3.4	-1.1	-0.9	-1.0	-0.0	-1.3	-0.1	-1.8	0.2	0.6
Bone: cortical thickness	0.8	1.4	6.6	-0.0	-2.6	1.0	-1.6	-0.3	0.4	-0.9	0.4	1.2
Bone: cortical thickness	0.5	0.6	1.9	0.3	-1.0	-0.3	-0.8	-0.7	-0.3	-0.6	0.8	1.4
Bone: cortical tissue density	0.9	1.2	3.9	-0.4	-1.8	1.6	-2.0	-0.0	-0.1	0.4	0.6	0.7
Condit. Reinf. active minus inactive responses	0.8	0.9	3.0	-0.8	1.4	0.3	-0.5	0.1	-1.2	1.7	0.7	-0.2
Condit. Reinf. active-inactive response ratio	0.4	0.5	2.0	1.2	0.3	0.3	-0.1	0.6	0.0	1.4	0.3	0.2
Condit. Reinf. active responses	0.9	1.1	3.8	-1.0	2.0	0.3	0.1	0.4	-1.0	1.6	0.1	-1.0
Condit. Reinf. inactive responses	0.6	0.7	2.5	-1.4	1.6	-0.0	0.4	0.1	-0.5	0.2	-0.3	-1.2
Incentive salience index mean	0.8	1.0	3.9	-1.1	2.0	-1.2	0.7	-0.7	-1.2	0.3	0.5	-0.2
Condit. Reinf. lever presses	2.2	3.1	8.8	-1.7	1.9	-3.0	1.8	-1.9	-0.9	-2.2	0.2	0.2
Condit. Reinf. active minus inactive responses	2.7	3.5	7.6	2.8	1.0	1.4	1.1	2.6	1.8	2.0	-1.6	-1.8
Condit. Reinf. active-inactive response ratio	2.5	2.9	6.7	2.6	-0.0	1.5	0.8	2.3	2.1	1.0	-1.8	-1.5
Condit. Reinf. active responses	1.0	1.4	4.3	1.5	1.8	0.1	0.8	1.3	0.1	2.1	-0.2	-0.7
Condit. Reinf. inactive responses	1.3	1.7	3.8	-1.0	1.7	-1.7	0.2	-1.1	-1.9	0.8	1.5	0.9
Condit. Reinf. lever presses	1.4	1.9	6.8	2.6	0.8	-0.3	1.8	1.4	1.5	0.4	-1.2	-0.8
Condit. Reinf. lever reinforcers received	0.9	1.3	4.0	1.5	1.6	0.1	0.6	1.3	0.1	2.0	-0.1	-0.6
Conditioned reinforcement - actives	0.3	0.5	1.6	0.7	0.7	-1.3	0.9	-0.3	0.2	-1.1	-0.1	0.3
Conditioned reinforcement - inactives	0.0	0.0	0.2	0.1	0.4	-0.1	0.1	-0.1	-0.1	0.1	0.2	0.1
Conditioned locomotion	0.7	1.0	2.2	-0.6	-0.5	-0.6	-0.9	-1.2	-1.2	-0.3	1.3	1.5
Patch foraging indifference point 0 sec	0.6	1.1	2.3	1.5	0.2	0.8	0.7	1.5	1.2	0.6	-1.1	-1.1
Patch foraging indifference point AUC	1.8	2.5	7.2	-2.7	0.1	-0.9	-1.3	-2.0	-2.2	-0.4	1.7	1.2
Delay disc. indifference point, 0s delay	0.5	0.5	1.7	-0.8	0.7	0.8	-0.4	0.4	-0.5	1.3	0.0	-0.8
Delay disc. indifference point, 16s delay	0.2	0.2	0.5	-0.2	0.1	-0.1	-0.3	-0.3	-0.6	0.3	0.7	0.7
Delay disc. indifference point, 2s delay	0.4	0.5	2.3	0.3	1.2	0.0	0.1	0.4	-0.6	1.5	0.4	-0.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.4	-0.3	0.6	-0.1	0.0	-0.1	-0.5	0.3	0.3	0.2
Delay disc. indifference point, 4s delay	0.5	0.5	1.8	0.4	1.3	-0.0	0.8	0.8	-0.0	1.0	-0.3	-0.7
Delay disc. indifference point, 8s delay	1.2	1.4	6.2	0.4	2.5	-1.4	1.3	0.1	-0.8	1.2	0.4	-0.1
Indifference point function ln k	2.0	3.4	9.2	3.0	0.4	1.0	1.5	2.4	2.4	0.8	-2.0	-1.6
Indifference point function log k	2.0	3.4	9.2	3.0	0.4	1.0	1.5	2.4	2.4	0.8	-2.0	-1.6
Patch foraging total patch changes 0 sec	0.3	0.6	1.7	1.3	0.1	0.7	0.4	1.1	0.8	0.5	-0.7	-0.7
Patch foraging total patch changes 12 sec	0.9	1.2	3.6	-1.9	-0.7	-0.3	-1.0	-1.3	-1.2	-0.8	0.9	0.8
Patch foraging total patch changes 18 sec	0.2	0.3	0.6	-0.4	-0.8	-0.3	-0.4	-0.6	-0.3	-0.7	0.5	0.7
Patch foraging total patch changes 24 sec	0.5	0.8	2.5	-0.2	0.0	1.6	-0.9	0.8	-0.2	1.6	0.0	-0.7
Patch foraging total patch changes 6 sec	0.4	0.5	2.1	-0.7	-0.2	1.5	-0.6	0.6	0.1	0.7	-0.4	-0.9
Patch foraging time to switch 0 sec	0.2	0.5	2.0	-0.5	-1.1	0.1	0.0	-0.3	0.5	-1.4	-0.5	-0.1
Patch foraging water rate 0 sec	0.8	1.6	5.7	2.1	1.3	0.2	0.5	1.4	0.2	2.4	-0.0	-0.4
Patch foraging water rate 12 sec	1.8	3.7	7.7	2.8	1.6	1.3	1.2	2.6	1.3	2.6	-1.3	-1.7
Patch foraging water rate 18 sec	1.0	1.5	5.6	1.2	0.1	1.8	-1.2	1.3	0.0	2.4	0.3	-0.1
Patch foraging water rate 24 sec	1.0	1.4	3.0	1.3	0.1	1.7	-0.3	1.7	0.8	1.6	-0.7	-1.0
Patch foraging water rate 6 sec	1.7	2.5	5.2	2.3	1.5	0.8	1.2	2.1	1.1	2.0	-1.1	-1.5
Seeking ratio, delayed vs. immediate footshock	1.8	2.2	6.1	1.1	2.4	-1.3	2.5	1.0	0.5	0.9	-1.0	-1.4
Distance traveled before self-admin	1.4	1.8	3.2	1.4	1.3	0.1	1.8	1.5	1.3	0.6	-1.6	-1.7
Distance traveled after self-admin	1.4	1.7	4.8	1.6	1.7	-1.4	2.2	0.6	0.9	0.1	-1.0	-0.8
Extensor digitorum longus weight	0.4	1.7	7.4	0.4	2.7	-0.3	1.2	0.8	-0.5	2.1	-0.1	-1.1
Bone: elastic displacement	0.8	0.9	2.1	-1.1	-0.3	0.3	-1.5	-0.6	-1.2	0.6	1.2	0.9
Bone: elastic work	0.2	0.2	0.8	-0.2	-0.7	0.5	-0.9	-0.1	-0.3	0.2	0.5	0.5
Bone: endosteal estimation	1.9	4.1	12.6	2.1	2.8	-2.1	3.5	1.1	1.2	0.0	-1.6	-1.6
Bone: endosteal perimeter	0.9	2.0	6.6	1.1	2.2	-1.9	2.6	0.4	0.5	-0.1	-0.9	-0.9
Epididymis fat weight	1.3	4.3	12.4	-3.5	-1.8	1.3	-3.2	-1.7	-2.0	-0.3	1.8	1.2
Delta time in closed arm before/after self-admin	1.0	0.9	1.9	-0.6	-1.0	0.1	-1.4	-1.0	-0.9	-0.2	1.2	1.3
Delta time in open arm before/after self-admin	3.4	3.3	6.8	1.3	-1.5	2.1	0.5	2.1	2.6	-0.6	-2.5	-2.0
Diff in mean of infusions in LGA sessions	1.1	1.4	5.0	0.9	1.7	-2.2	1.8	0.0	-0.1	-0.5	-0.0	0.2
Delay discount exponential model param	0.6	0.7	3.1	-0.4	-1.8	0.6	-0.9	-0.4	0.4	-1.1	-0.1	0.3
Extinction: sum of active levers before priming	0.3	0.3	0.9	0.6	0.3	-0.6	1.0	0.1	0.6	-0.6	-0.6	-0.3
Active lever presses in extinction session 6	1.5	1.5	2.4	1.5	1.1	-0.0	1.6	1.4	1.1	0.6	-1.3	-1.4
Bone: final force	0.1	0.1	0.3	0.5	0.5	-0.5	0.5	0.2	0.1	0.1	-0.0	0.1
Bone: final moment	0.0	0.1	0.2	0.4	0.0	-0.5	0.2	-0.0	0.0	-0.1	0.2	0.4
Food consumed during 24 hour testing period	1.8	2.4	7.1	2.7	2.1	-2.1	2.3	0.5	0.4	0.3	-0.1	0.2
Glucose	0.1	0.2	0.5	0.4	0.1	0.7	-0.1	0.5	0.4	0.5	-0.4	-0.4
Heart weight	0.5	0.8	3.1	-0.1	1.8	0.5	0.0	0.6	-0.6	1.7	0.3	-0.4
Delay discount hyperbolic model param	0.6	0.7	3.1	-0.3	-1.8	0.7	-0.8	-0.3	0.6	-1.1	-0.3	0.1
Intermittent access intake day 1-15 change	0.4	0.7	3.5	0.2	1.9	-1.2	0.8	-0.1	-0.8	0.4	0.6	0.2
Intermittent access intake escalation	0.3	0.6	3.3	0.0	1.8	-0.9	0.6	-0.1	-0.8	0.5	0.5	0.1
Intermittent access intake escalation 2	1.0	1.2	5.6	0.8	2.4	-1.2	1.5	0.3	-0.3	0.7	-0.1	-0.5
Intermitt. access day 1 inactive lever presses	0.1	0.5	1.6	-0.2	-1.3	-0.3	-0.7	-0.8	-0.5	-0.5	0.7	1.0
Intermitt. access day 15 inactive lever presses	0.6	1.2	2.7	-1.6	-0.3	0.1	-1.3	-1.2	-1.5	0.3	1.3	0.9
Intermitt. access escalation Index	0.4	0.5	1.0	0.9	1.0	-0.8	0.4	0.3	-0.4	0.9	0.7	0.9
Intermittent access day 1 total infusions	0.6	1.0	2.5	-1.0	-0.8	-1.0	-0.3	-1.3	-0.5	-1.6	0.6	1.1
Intermittent access day 15 total infusions	0.6	0.9	1.9	-0.8	0.3	-1.4	0.2	-1.1	-0.9	-1.2	0.8	1.0
Intermittent access terminal intake (last 3 days)	0.8	1.1	3.9	-0.3	0.6	-2.0	0.6	-1.1	-0.9	-1.1	0.8	1.0
Intermittent access total infusions	0.9	1.1	3.7	-0.4	-0.2	-1.8	0.6	-1.2	-0.4	-1.9	0.4	1.0
Intermittent access day 1 locomotion	1.5	1.9	3.1	-1.7	-0.8	-0.7	-1.2	-1.7	-1.4	-1.0	1.6	1.8
Intermittent access day 15 total locomotion	0.5	1.0	1.9	-0.9	-0.7	-0.9	-0.5	-1.4	-0.9	-1.1	1.0	1.2
Intermittent access total locomotion	0.3	0.4	1.5	0.1	0.2	-1.2	0.4	-0.6	-0.3	-0.7	0.5	0.7
Intermittent access standard deviation	0.5	1.1	2.8	-1.0	0.3	-1.7	0.1	-1.4	-1.2	-1.0	1.0	1.0
Left kidney weight	0.3	1.4	2.5	0.5	1.5	-1.5	0.2	-0.7	-1.4	1.0	1.6	1.4
Right kidney weight	0.2	0.8	1.7	0.1	1.3	-0.7	0.0	-0.3	-1.2	1.2	1.1	0.7
Cocaine induced anxiety	0.1	0.2	1.1	-0.1	-0.2	-0.7	0.4	-0.2	0.1	-1.1	-0.2	0.1
Post-drug Anxiety	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.0	0.2	0.3	-0.4	-0.5	-0.4
Baseline Anxiety	1.2	1.4	6.7	-0.5	-0.8	2.6	-1.3	0.9	0.4	1.4	-0.4	-0.9
Tail length	0.3	1.0	2.7	-1.7	0.6	-0.3	-0.9	-0.9	-1.6	0.3	1.2	0.6
Length with tail	0.3	1.1	3.0	-0.8	1.3	-0.4	-0.7	-0.4	-1.7	1.3	1.4	0.7
Length without tail	0.7	2.4	7.1	1.1	2.7	-1.6	0.8	0.0	-1.5	2.2	1.4	0.9
Times rat made contact with spout	0.8	0.9	2.8	1.7	1.2	-1.3	1.3	0.3	0.2	0.3	-0.0	0.2
Lifetime Intake	1.0	1.2	4.3	-0.7	-0.3	-1.6	0.4	-1.3	-0.4	-2.1	0.4	0.9
Liver weight, left	0.3	0.4	1.0	-0.1	1.0	-0.6	-0.1	-0.3	-0.9	0.6	0.9	0.7
Liver weight, right	0.6	1.1	2.8	-0.1	1.7	-0.9	-0.1	-0.5	-1.3	1.4	1.3	0.9
Locomotor activity	0.1	0.2	0.5	0.4	0.5	-0.7	0.3	-0.2	-0.4	-0.2	0.4	0.5
Locomotor testing distance	0.2	0.4	2.0	1.4	0.0	0.3	0.2	0.8	0.4	0.4	-0.2	-0.1
Locomotor testing rearing	0.3	0.6	2.0	1.4	-0.2	0.8	-0.0	1.1	0.5	0.9	-0.3	-0.4
Locomotion in novel chamber	0.1	0.1	0.2	0.2	-0.3	-0.5	0.4	-0.3	0.3	-0.5	-0.2	-0.0
Locomotion in novel chamber post-restriction	0.1	0.2	0.8	-0.5	-0.6	0.4	-0.9	-0.3	-0.4	0.1	0.4	0.3
Fecal boli incidents, locomotor time 1	1.5	2.1	5.7	-1.2	1.8	-2.4	0.7	-1.7	-1.7	-0.3	1.3	1.0
Change in fecal boli incidents, locomotor task	4.8	4.7	10.2	3.0	-1.0	1.6	1.4	2.5	3.2	-0.1	-2.7	-2.0
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.5	-0.2	0.8	-1.2	1.1	-0.4	0.0	-0.9	-0.3	-0.2
Bouts of movement, locomotor time 1	0.6	0.7	1.6	-1.1	1.0	-0.8	-0.1	-0.9	-1.3	0.0	1.0	0.6
Total resting periods, locomotor time 1	0.4	0.4	0.9	-0.7	0.9	-0.7	-0.0	-0.6	-0.9	0.1	0.8	0.6
Rest time, locomotor task time 1	0.8	1.0	2.5	1.0	0.9	-0.8	-0.1	-0.1	-0.9	1.6	1.3	1.2
Distance moved, locomotor task time 1	0.3	0.4	1.2	-1.0	-0.5	1.1	-0.8	0.1	-0.1	0.0	-0.2	-0.5
Vertical activity count, locomotor time 1	0.1	0.2	1.0	-1.0	-0.5	0.4	-0.5	-0.3	-0.2	-0.4	-0.0	-0.2
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.5	-0.3	-0.1	-1.2	-0.2	-1.1	-0.7	-0.3	0.9	1.2
Bouts of movement, locomotor time 2	1.0	1.6	4.3	-2.1	0.1	0.0	-1.5	-1.3	-1.8	0.3	1.5	1.0
Total resting periods, locomotor time 2	0.7	1.2	3.1	-1.8	0.1	-0.1	-1.2	-1.1	-1.5	0.2	1.3	0.9
Rest time, locomotor task time 2	0.4	0.5	1.6	-0.1	-1.3	0.3	-1.1	-0.5	-0.3	-0.3	0.7	1.1
Distance moved, locomotor task time 2	0.5	0.6	1.5	-0.2	0.8	0.8	0.1	0.8	0.2	1.2	-0.5	-1.2
Vertical activity count, locomotor time 2	0.1	0.1	0.4	-0.2	0.6	-0.4	0.3	-0.1	-0.2	0.4	0.0	-0.2
Light reinforcement 1	0.9	2.3	7.7	-0.6	2.8	-1.8	0.5	-0.7	-2.1	1.2	1.6	0.9
Light reinforcement 2	0.8	1.2	4.4	-0.2	-0.7	-1.7	0.7	-1.3	0.0	-2.1	0.2	1.0
Bone: marrow area	1.8	4.0	12.6	2.1	2.8	-2.2	3.5	1.0	1.1	-0.1	-1.5	-1.5
Bone: maximum diameter	2.2	4.1	12.0	2.6	2.8	-2.3	3.5	1.0	1.0	0.3	-1.2	-1.0
Bone: maximum force	0.2	0.3	0.9	0.7	0.7	-0.8	1.0	0.2	0.3	-0.2	-0.3	-0.2
Bone: maximum moment	0.1	0.2	0.5	0.6	0.2	-0.7	0.7	0.0	0.3	-0.4	-0.1	0.2
Mean time between licks in bursts	0.4	0.9	1.9	-1.0	-0.6	-1.0	-0.3	-1.4	-0.8	-1.3	0.8	1.1
Mean num. licks in bursts	0.3	0.5	1.4	0.3	-0.6	0.5	-1.2	-0.1	-0.5	0.6	0.9	1.0
Cd content in liver	1.6	1.8	4.7	-1.4	0.1	1.7	-2.2	0.1	-1.5	1.7	1.2	0.3
Co content in liver	2.5	2.9	6.2	-1.6	0.3	-0.6	-1.8	-1.6	-2.5	0.8	2.5	2.1
Cu content in liver	0.2	0.2	0.4	-0.2	-0.1	-0.6	-0.1	-0.5	-0.5	-0.2	0.6	0.6
Fe content in liver	5.1	6.2	12.2	2.1	0.8	1.0	2.8	2.8	3.2	-0.1	-3.5	-3.4
K content in liver	0.1	0.1	0.3	0.3	-0.2	0.5	-0.1	0.5	0.2	0.5	-0.2	-0.3
Mg content in liver	0.6	0.7	1.5	1.2	0.6	0.4	0.6	1.1	0.6	1.0	-0.6	-0.7
Mn content in liver	1.1	1.2	5.4	0.0	-0.9	-1.5	0.6	-1.1	0.4	-2.3	-0.1	0.9
Na content in liver	1.2	1.3	3.2	0.3	0.6	-0.3	1.8	0.8	1.2	-0.7	-1.7	-1.7
Rb content in liver	1.9	2.2	4.2	1.4	0.7	1.3	1.0	2.0	1.5	1.4	-1.7	-2.0
Se content in liver	0.8	0.9	2.2	0.5	-1.3	0.8	0.3	0.6	1.5	-0.7	-1.3	-0.9
Sr content in liver	0.6	0.5	1.5	-1.2	0.1	-0.8	0.2	-0.9	-0.5	-1.1	0.2	0.2
Zn content in liver	0.9	1.0	2.2	-1.2	-1.1	0.1	-1.5	-1.0	-1.0	-0.1	1.2	1.2
Bone: minimum diameter	0.2	0.4	1.4	0.2	0.2	-1.2	0.4	-0.6	-0.3	-0.7	0.5	0.9
Time in familiar zone, hab. session 1	0.9	0.9	2.5	0.2	1.5	-1.5	1.6	-0.3	0.1	-0.7	-0.4	-0.3
Time in novel zone, hab. session 1	1.3	1.3	3.0	0.7	-1.2	1.5	-1.6	0.7	-0.2	1.7	0.7	0.6
Total zone transitions, hab. session 1	0.7	1.0	5.1	-2.3	-0.5	1.1	-1.3	-0.4	-0.8	-0.1	0.3	-0.3
Total locomotion distance, hab. session 1	1.1	1.6	6.0	-2.5	-0.8	1.7	-1.9	-0.3	-0.8	0.3	0.3	-0.4
Locomotion velocity, hab. session 1	0.8	1.1	5.3	-2.3	-0.6	1.1	-1.3	-0.5	-0.6	-0.2	0.1	-0.4
Time in familiar zone, hab. session 2	0.6	0.6	1.6	1.3	0.3	0.6	0.4	0.9	0.8	0.8	-0.7	-0.6
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.1	-0.4	-0.3	-0.0	-0.3	-0.0	-0.5	0.2	0.4
Total zone transitions, hab. session 2	1.0	1.3	7.0	-2.6	0.6	0.4	-1.0	-0.8	-1.4	-0.2	0.6	-0.3
Total locomotion distance, hab. session 2	1.7	2.3	11.4	-3.4	0.3	0.2	-1.4	-1.4	-1.9	-0.3	1.1	0.1
Locomotion velocity, hab. session 2	2.1	2.8	13.3	-3.6	-0.0	-0.1	-1.4	-1.8	-2.0	-0.9	1.2	0.4
Novel to familiar place preference ratio	0.2	0.2	0.6	0.2	0.8	-0.5	0.3	-0.1	-0.4	0.5	0.4	0.3
Novelty place preference	0.4	0.4	1.3	0.5	1.1	-0.9	0.6	-0.1	-0.4	0.6	0.4	0.3
Time in novel zone, NPP test	0.6	0.7	1.7	1.3	1.3	-0.7	0.9	0.4	0.0	1.1	0.1	0.1
Total zone transitions, NPP test	0.3	0.4	1.5	-1.2	0.7	0.8	-0.3	0.2	-0.4	0.5	-0.1	-0.8
Total locomotion distance, NPP test	0.6	0.8	4.6	-2.1	0.8	0.4	-0.5	-0.5	-1.0	0.2	0.3	-0.6
Locomotion velocity, NPP test	0.9	1.2	7.9	-2.8	0.3	0.5	-0.7	-0.8	-1.0	-0.4	0.2	-0.6
Intraocular pressure	0.6	0.8	3.8	0.9	0.1	1.1	-0.6	1.0	-0.1	1.9	0.3	0.0
Delta distance traveled before/after self-admin	0.7	0.8	1.8	0.3	0.7	-1.3	-0.0	-0.9	-0.9	0.2	1.2	1.4
Delta ambulatory time before/after self-admin	0.6	0.7	1.9	0.7	0.5	-1.3	0.1	-0.8	-0.6	-0.0	1.0	1.4
Parametrial fat weight	1.4	3.4	8.4	-2.9	-1.1	-0.2	-2.0	-2.1	-2.1	-0.9	1.9	1.8
Pavlov. Cond. lever latency	1.5	1.9	4.8	1.5	-1.9	2.2	-1.6	1.2	0.9	1.3	-0.1	0.3
Pavlov. Cond. magazine entry latency	3.2	4.1	10.2	-3.2	0.6	-2.4	-0.0	-2.8	-2.0	-2.2	1.4	1.3
Pavlov. Cond. change in total contacts	2.6	2.8	6.1	-2.5	0.8	-2.1	0.0	-2.2	-1.9	-1.3	1.4	1.1
Pavlov. Cond. index score	2.8	3.5	9.0	-3.0	1.1	-2.4	0.5	-2.5	-1.8	-2.0	1.0	0.8
Pavlov. Cond. latency score	2.3	2.9	7.3	-2.7	1.1	-2.3	0.6	-2.2	-1.6	-1.9	0.8	0.6
Pavlov. Cond. lever contacts	2.0	2.3	5.8	-2.0	1.6	-2.4	1.1	-1.8	-1.3	-1.5	0.6	0.4
Pavlov. Cond. magazine entry number	2.2	2.8	7.8	2.8	-0.5	1.8	0.2	2.3	1.8	1.7	-1.2	-1.0
Pavlov. Cond. intertrial magazine entries	2.9	3.4	7.1	1.5	0.5	2.4	0.3	2.7	1.4	2.3	-1.7	-2.4
Pavlov. Cond. lever-magazine prob. diff.	3.2	3.9	10.1	-3.2	1.2	-2.6	0.5	-2.6	-1.9	-2.2	1.1	0.8
Pavlov. Cond. response bias	2.5	3.1	7.8	-2.8	1.1	-2.2	0.3	-2.4	-1.8	-1.8	1.1	0.8
Pavlov. Cond. lever latency	1.3	1.8	4.0	-1.9	-1.7	0.7	-2.0	-1.2	-0.9	-0.5	1.0	1.1
Pavlov. Cond. magazine entry latency	0.8	0.9	4.6	-0.3	-1.5	-0.1	0.1	-0.4	0.8	-2.2	-0.7	-0.1
Pavlov. Cond. change in total contacts	0.2	0.3	0.9	0.9	0.5	0.1	0.7	0.7	0.6	0.3	-0.6	-0.5
Pavlov. Cond. index score	0.6	0.8	1.9	1.0	0.3	-0.4	1.4	0.6	1.1	-0.8	-1.1	-0.8
Pavlov. Cond. latency score	1.0	1.3	2.9	1.4	0.4	-0.5	1.7	0.9	1.4	-0.8	-1.4	-1.0
Pavlov. Cond. lever contacts	1.3	1.8	4.2	2.0	1.7	-0.8	2.0	1.1	1.0	0.5	-1.0	-1.0
Pavlov. Cond. magazine entry number	0.8	1.0	2.4	-0.6	0.7	-0.1	-0.9	-0.4	-1.4	1.5	1.4	0.9
Pavlov. Cond. intertrial magazine entries	0.5	0.8	1.9	-1.0	1.1	-1.0	-0.1	-0.9	-1.4	0.4	1.1	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.6	0.8	0.3	-0.6	1.3	0.4	0.9	-1.0	-0.9	-0.6
Pavlov. Cond. response bias	0.4	0.5	1.2	0.7	0.5	-0.3	1.1	0.6	0.8	-0.3	-0.9	-0.8
Time in closed arm before self-admin	0.6	0.8	2.6	0.2	1.2	-1.3	1.6	-0.1	0.4	-0.7	-0.7	-0.6
Time in closed arm after self-admin	0.4	0.5	0.9	-1.0	-0.3	-0.3	-0.6	-0.9	-0.7	-0.5	0.7	0.7
Time in open arm before self-admin	0.6	0.7	2.2	0.6	0.9	-1.5	0.5	-0.3	-0.7	0.3	0.9	0.9
Time in open arm after self-admin	2.6	2.9	5.6	2.2	0.0	0.2	1.9	1.9	2.4	-0.6	-2.2	-1.6
Bone: periosteal estimation	1.2	2.6	7.9	2.1	1.9	-1.7	2.8	0.9	1.1	-0.1	-1.2	-0.9
Bone: periosteal perimeter	1.0	1.6	4.1	1.8	0.9	-0.7	2.0	1.0	1.4	-0.2	-1.4	-1.0
Bone: post-yield work	1.6	2.4	6.1	1.7	1.9	-0.8	2.5	1.3	1.2	0.3	-1.5	-1.6
Progressive ratio test 1 active lever presses	0.9	1.1	3.2	-0.4	0.1	-1.8	0.3	-1.2	-0.7	-1.5	0.9	1.4
Progressive ratio test 1 breakpoint	1.1	1.3	4.0	-0.3	0.1	-2.0	0.4	-1.3	-0.7	-1.6	0.9	1.4
Progressive ratio test 1 inactive lever presses	0.4	0.6	1.1	-0.3	-0.7	-0.9	-0.2	-1.0	-0.5	-0.9	0.7	1.1
Progressive ratio test 2 active lever presses	0.7	0.9	2.5	-0.5	0.2	-1.6	0.4	-1.1	-0.7	-1.2	0.7	1.0
Progressive ratio test 2 breakpoint	0.7	0.8	2.1	-0.6	0.2	-1.5	0.3	-1.2	-0.7	-1.3	0.7	1.0
Progressive ratio test 2 inactive lever presses	0.5	0.8	1.9	-0.5	-0.9	-1.0	-0.2	-1.2	-0.4	-1.4	0.6	1.0
Incentive Sensitization - Responses	0.5	0.7	2.0	-0.7	-0.0	-1.3	0.2	-1.4	-0.8	-0.8	0.7	0.8
Incentive Sensitization - Breakpoint	0.6	0.8	2.3	-1.0	-0.1	-1.1	-0.1	-1.5	-1.0	-0.7	0.9	0.9
Sum of active levers in priming session hrs 5-6	1.7	1.5	3.8	1.9	0.5	0.5	1.2	1.4	1.5	0.8	-1.3	-1.2
Progressive ratio	0.8	1.2	3.7	-0.8	0.8	-1.9	0.4	-1.6	-1.3	-0.2	1.1	0.9
Food seeking constrained by brief footshock	3.3	4.0	8.2	2.9	2.5	-0.2	2.1	2.6	1.1	2.4	-1.2	-1.5
Seeking ratio, punishment vs. effort	2.3	3.3	8.2	2.2	0.8	1.6	1.0	2.9	1.9	1.5	-1.8	-1.9
Retroperitoneal fat weight	1.6	6.9	16.5	-3.9	-1.7	1.3	-4.1	-2.1	-3.0	0.3	2.9	2.2
Reaction time number correct	0.6	1.2	2.4	0.8	0.7	0.9	0.9	1.4	1.3	-0.0	-1.5	-1.6
Reaction time mean minus median	0.3	0.7	1.8	-1.0	-1.1	0.5	-1.3	-0.7	-0.5	-0.4	0.7	0.9
Reaction time mean minus median AUC	0.1	0.3	1.3	-0.4	-1.2	0.6	-0.9	-0.3	0.1	-0.5	0.1	0.4
Reaction time num false alarms	0.4	0.6	2.1	-0.4	-1.4	1.3	-0.9	0.4	0.4	-0.2	-0.3	-0.3
Reaction time num false alarms AUC	0.4	0.7	2.2	-0.3	-1.5	1.4	-0.8	0.5	0.6	-0.2	-0.6	-0.5
Reaction time trials correct on left	0.6	1.2	2.4	0.8	0.7	0.9	0.9	1.4	1.3	-0.0	-1.5	-1.6
Reaction time trials on left	0.7	1.3	2.6	0.8	0.6	1.0	0.8	1.4	1.3	-0.1	-1.5	-1.6
Reaction time mean	0.4	0.7	1.9	-0.8	-1.4	-0.1	-0.8	-0.9	-0.2	-1.0	0.5	1.0
Reaction time mean AUC	0.2	0.4	1.2	-0.6	-1.1	0.1	-0.6	-0.6	-0.0	-0.8	0.2	0.7
Median of all reaction times	0.5	0.7	1.9	-0.8	-1.4	-0.2	-0.7	-1.0	-0.2	-1.1	0.5	1.0
Reaction time omissions	1.0	1.5	4.5	-1.2	-2.1	1.9	-1.7	0.1	0.4	-0.8	-0.3	-0.3
Reaction time false alarm rate	0.5	0.7	2.9	-0.6	-1.7	0.9	-1.3	-0.2	-0.1	-0.0	0.3	0.4
Reaction time premature initiation rate	0.3	0.4	1.6	0.1	0.6	0.4	-0.5	0.3	-0.6	1.3	0.6	0.2
Reaction time premature initiations	0.3	0.5	1.4	0.5	0.9	0.8	-0.1	0.9	0.1	1.2	-0.2	-0.5
Std. dev. reaction times	0.4	0.7	2.4	-0.9	-1.6	0.7	-1.3	-0.6	-0.1	-0.7	0.3	0.7
Reaction time trials completed	0.7	1.3	2.6	0.8	0.6	1.0	0.8	1.4	1.3	-0.1	-1.5	-1.6
Reaction time trials AUC	0.8	1.4	2.9	0.9	0.6	1.0	0.9	1.5	1.4	-0.0	-1.6	-1.7
Run reversals in cocaine runway, females	0.4	0.4	1.5	0.4	-1.2	0.6	-0.9	0.5	0.0	0.1	0.3	0.6
Run reversals in cocaine runway, males	0.6	0.6	1.9	0.3	1.4	0.2	0.7	0.8	0.1	1.0	-0.5	-1.1
Latency to leave start box in cocaine runway	0.4	0.4	1.0	0.2	0.1	-0.2	0.9	0.2	0.8	-0.8	-1.0	-0.8
Latency to leave start box in cocaine runway, F	0.0	0.1	0.2	-0.1	0.4	-0.2	0.3	-0.3	0.1	-0.2	-0.2	-0.2
Latency to leave start box in cocaine runway, M	0.7	0.7	1.5	0.4	-0.5	0.2	0.8	0.8	1.1	-0.9	-1.2	-1.0
Std. dev. time between licks in bursts	0.5	0.6	1.2	-0.8	1.0	-0.9	1.1	-0.4	-0.1	-1.1	-0.4	-0.6
Total sessions with >9 infusions	0.7	0.9	2.7	-0.7	0.3	-1.6	0.6	-1.2	-0.6	-1.3	0.5	0.8
Short access day 1 total inactive lever presses	1.0	1.3	2.9	-0.4	-0.3	-1.1	-0.6	-1.6	-1.2	-0.6	1.5	1.7
Short access day 10 total inactive lever presses	0.1	0.2	0.4	-0.4	-0.4	-0.0	-0.5	-0.5	-0.6	0.2	0.6	0.5
Short access day 1 total infusions	0.5	0.7	1.8	-0.5	-0.1	-1.3	0.4	-1.2	-0.5	-1.3	0.4	0.6
Short access day 10 total infusions	1.0	1.3	6.6	-0.2	-1.1	-1.3	0.6	-0.9	0.5	-2.6	-0.3	0.5
Short access total infusions	1.0	1.2	5.1	-1.0	-0.9	-1.2	0.0	-1.3	-0.3	-2.3	0.3	0.9
Short access day 1 locomotion	0.6	0.7	1.5	-0.4	1.2	-1.2	0.2	-0.7	-1.2	0.1	1.0	0.8
Short access day 10 total locomotion	0.2	0.3	0.8	0.4	0.1	-0.8	0.9	-0.3	0.4	-0.6	-0.4	-0.1
Short access total locomotion	0.9	1.1	3.4	-0.4	-0.0	-1.8	0.4	-1.5	-0.7	-1.3	0.8	1.2
One hour access (0.3 mA shock)	0.4	0.4	1.4	-0.4	-0.3	-0.9	0.1	-0.8	-0.3	-1.2	0.4	0.7
Compulsive drug intake	1.1	1.3	3.8	2.0	-0.9	0.4	0.8	1.2	1.8	-0.2	-1.2	-0.6
One hour access (shock baseline)	0.7	1.1	2.7	-1.4	0.2	-1.4	0.2	-1.4	-0.9	-1.7	0.6	0.6
Social response proportion	0.3	0.3	0.9	0.5	-0.9	0.2	-0.6	-0.2	0.1	-0.6	0.4	0.9
Social responses	0.5	0.6	1.3	-0.6	0.2	-1.1	0.0	-1.1	-0.7	-1.1	0.7	0.9
Social time	0.2	0.2	0.7	0.8	-0.2	0.3	0.3	0.6	0.6	-0.3	-0.5	-0.2
Soleus weight	2.7	8.0	28.7	2.7	5.4	-1.7	3.9	2.0	0.3	2.7	-1.2	-2.2
Bone: stiffness	0.4	0.7	1.3	0.7	0.3	0.8	0.4	1.2	0.9	0.6	-1.0	-1.1
Tibialis anterior weight	2.2	7.3	14.2	3.3	3.8	-0.4	3.5	2.8	1.6	2.5	-2.1	-2.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	0.2	-0.1	0.7	-0.2	0.1	0.5	0.4	-0.5	-0.5
Time to tail flick, vehicle, after self-admin	0.8	1.0	3.0	1.2	0.3	-0.7	1.7	0.7	1.1	-0.7	-1.2	-0.8
Time to tail flick, test, before self-admin	1.2	1.2	2.9	-1.7	0.1	-0.2	-1.1	-0.9	-1.7	0.2	1.4	1.0
Time to tail flick, test, after self-admin	0.7	0.7	1.5	-0.1	1.2	-1.2	0.3	-0.4	-1.1	0.6	1.0	0.7
Delta time to tail flick, vehicle, before/after SA	0.9	0.8	2.5	0.7	0.7	-0.6	1.6	1.0	0.7	-0.4	-1.0	-1.0
Delta time to tail flick, test, before/after SA	1.0	1.0	4.1	2.0	0.6	-0.8	1.4	0.7	1.0	0.0	-0.7	-0.2
Tibia length	1.1	3.1	12.3	0.3	1.0	-3.5	1.3	-1.9	-1.2	-1.1	1.5	2.1
Ambulatory time before self-admin	0.5	0.8	1.8	0.3	0.9	-0.1	1.3	0.7	0.8	-0.2	-1.2	-1.3
Ambulatory time after self-admin	1.3	1.6	4.4	1.7	1.5	-1.4	2.1	0.6	1.0	-0.0	-0.9	-0.6
Bone: tissue strength	0.3	0.3	0.8	0.5	-0.9	0.9	-0.6	0.4	0.4	0.3	-0.1	0.1
Total heroin consumption	0.5	0.6	2.1	1.0	1.5	-0.5	1.0	0.3	0.2	0.9	-0.3	-0.5
Bone: trabecular number	0.3	0.5	1.7	-1.3	0.1	-0.3	0.5	-0.4	0.1	-1.1	-0.6	-0.7
Bone: trabecular spacing	1.2	1.6	4.5	-1.3	-1.3	0.8	-2.1	-0.9	-1.2	-0.1	1.4	1.3
Bone: trabecular thickness	0.1	0.1	0.3	0.5	-0.3	-0.3	-0.1	-0.1	-0.0	0.0	0.3	0.6
Bone: trabecular tissue density	0.2	0.3	1.0	0.8	-0.6	0.1	-0.6	-0.0	-0.2	0.4	0.7	1.0
Water consumed over 24 hours	0.9	1.2	2.9	1.5	1.7	-1.6	1.7	0.2	0.1	0.1	-0.1	-0.0
Number of responses in last shaping day	2.0	2.2	8.9	0.3	1.9	-3.0	1.5	-1.3	-1.2	-0.7	0.9	0.9