Hub : Genes

Mapk6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Mapk6 0.27 0.09 0.0e+00 0.13 0.2 0.21 0.21 7.2e-14 3.4e-22 1.4e-22 1.5e-22
2 Brain gene expression Mapk6 0.06 0.03 2.3e-04 0 0.03 0.02 0.05 9.1e-02 3.4e-04 4.0e-03 1.9e-05
3 PL gene expression Mapk6 0.04 0.02 1.1e-05 0.03 0.05 0.03 0.04 3.5e-04 7.9e-06 7.6e-04 7.9e-05
4 Liver gene expression Mapk6 0.08 0.05 5.4e-04 0 0 0 0 8.4e-02 1.5e-01 2.3e-01 3.6e-01
5 NAcc gene expression Mapk6 0.1 0.05 6.2e-06 0.03 0.05 0.05 0.05 4.9e-04 1.9e-06 2.0e-06 4.6e-06
6 Adipose mRNA stability Mapk6 0.05 0.03 2.1e-03 0 0.01 0 0.01 1.4e-01 2.2e-02 9.0e-02 5.3e-02
7 Adipose intron excision ratio chr8_76158801_76168942 0.05 0.03 3.7e-04 0.01 0.01 0.01 0 2.0e-02 1.3e-02 6.8e-02 8.1e-02
8 Adipose intron excision ratio chr8_76158801_76169600 0.05 0.03 4.6e-04 0.01 0.01 0 0 2.2e-02 1.5e-02 8.9e-02 9.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.10.3-0.2-0.10.3-0.0-0.50.50.5-0.5
Area under the delay curve0.90.93.5-0.11.90.90.91.3-0.7-0.10.1
BMI with tail1.34.213.0-0.73.61.42.32.5-1.6-1.31.4
BMI without tail0.71.55.60.22.20.20.12.4-1.20.1-0.1
Body weight1.46.016.00.24.00.92.63.2-2.7-1.91.9
Weight adjusted by age1.31.54.6-0.12.11.62.10.3-0.7-0.10.1
Bone surface1.11.94.4-1.51.52.10.60.01.21.4-1.4
Bone volume0.40.71.9-0.91.11.40.60.20.60.7-0.7
Breakpoint value in progressive ratio session0.50.61.6-0.71.21.30.70.10.30.5-0.5
Number of licking bursts1.21.44.1-1.11.62.01.3-0.20.50.7-0.7
Context. condit. distance diff. score0.40.51.4-1.20.31.10.4-0.00.90.4-0.4
Locomotion velocity, session 10.40.41.7-0.21.00.20.21.3-0.40.1-0.1
Locomotion distance, session 10.30.41.61.2-0.2-0.3-0.2-0.7-0.40.6-0.6
Locomotion velocity, session 20.50.51.7-0.41.30.70.21.0-0.00.7-0.7
Locomotion distance, session 20.50.72.31.50.8-0.5-0.10.7-1.20.4-0.4
Locomotion velocity, session 32.42.86.9-1.1-0.31.0-1.4-0.72.02.6-2.6
Locomotion distance, session 32.02.24.90.1-1.5-0.6-2.2-0.91.41.9-2.0
Stereotopy head waving bouts, day 30.81.03.0-1.0-1.10.70.3-1.71.30.2-0.2
Stereotopy head waving duration, day 30.60.82.7-1.6-0.60.80.2-0.81.3-0.00.0
Locomotion velocity, session 70.20.20.4-0.0-0.40.1-0.3-0.40.50.6-0.6
Locomotion distance, session 70.20.30.8-0.20.20.5-0.2-0.10.40.9-0.9
Stereotopy head waving bouts, day 73.03.36.5-2.0-0.41.1-1.6-0.32.62.4-2.4
Stereotopy head waving duration, day 72.63.26.0-2.00.01.2-1.50.02.42.4-2.4
Locomotion velocity, session 81.51.84.2-1.20.70.9-1.00.81.32.0-2.0
Locomotion distance, session 80.40.61.7-0.10.80.90.10.00.31.3-1.3
Degree of sensitization distance1.31.33.6-0.11.30.81.90.4-1.0-1.21.2
Degree of sensitization stereotypy2.42.65.2-1.7-0.01.0-1.40.12.12.3-2.3
Conditioned locomotion1.92.24.32.0-0.1-1.21.2-0.2-2.1-1.81.8
Cocaine response after cond. corrected1.01.13.6-1.91.31.40.61.00.70.2-0.2
Cocaine response after cond. not corrected1.31.43.2-1.81.51.51.40.90.2-0.60.6
Cocaine response before conditioning1.11.44.00.11.40.72.00.4-1.2-1.21.2
Saline control response1.11.43.7-1.6-1.20.6-0.6-1.21.90.7-0.7
Bone: connectivity density0.50.92.40.7-1.0-0.3-0.7-1.60.61.0-1.0
Bone: cortical apparent density1.21.64.90.9-1.8-2.2-1.60.3-0.5-0.80.8
Bone: cortical area0.20.41.0-1.0-0.20.70.6-0.60.7-0.40.4
Bone: cortical porosity0.91.02.51.0-0.7-0.21.2-1.6-0.7-1.01.0
Bone: cortical porosity0.80.93.90.9-1.0-0.20.9-2.0-0.3-0.60.6
Bone: cortical thickness0.81.34.10.4-2.0-1.4-0.7-1.00.1-1.11.1
Bone: cortical thickness0.60.71.7-0.1-1.0-0.80.1-0.4-0.1-1.31.3
Bone: cortical tissue density1.11.54.50.8-1.6-2.1-1.50.4-0.5-0.80.8
Condit. Reinf. active minus inactive responses0.80.93.30.81.4-0.3-0.31.8-1.10.3-0.3
Condit. Reinf. active-inactive response ratio0.30.31.5-0.90.40.1-0.21.20.1-0.20.2
Condit. Reinf. active responses1.01.33.50.81.90.2-0.31.7-0.91.0-1.0
Condit. Reinf. inactive responses0.70.82.01.01.40.4-0.00.5-0.61.2-1.2
Incentive salience index mean0.81.03.50.81.90.81.30.5-1.20.1-0.1
Condit. Reinf. lever presses1.82.48.51.11.71.72.9-1.7-1.0-0.30.3
Condit. Reinf. active minus inactive responses2.43.08.2-2.90.71.2-1.31.72.01.6-1.6
Condit. Reinf. active-inactive response ratio2.32.46.9-2.6-0.30.9-1.40.62.31.4-1.4
Condit. Reinf. active responses1.01.44.0-1.61.71.1-0.02.00.40.6-0.6
Condit. Reinf. inactive responses1.31.63.51.01.90.41.61.0-1.8-0.90.9
Condit. Reinf. lever presses1.31.86.2-2.50.81.90.40.21.60.6-0.6
Condit. Reinf. lever reinforcers received0.91.33.9-1.61.50.9-0.02.00.30.4-0.4
Conditioned reinforcement - actives0.30.31.60.3-0.00.20.8-1.3-0.1-0.30.3
Conditioned reinforcement - inactives0.10.10.30.30.2-0.5-0.20.4-0.4-0.20.2
Conditioned locomotion1.51.83.71.3-0.8-1.01.2-0.6-1.4-1.91.9
Patch foraging indifference point 0 sec0.40.71.9-1.40.10.6-0.70.61.10.8-0.8
Patch foraging indifference point AUC1.61.95.82.40.1-1.20.8-0.3-2.0-1.21.2
Delay disc. indifference point, 0s delay0.60.62.00.40.8-0.2-0.71.4-0.40.8-0.8
Delay disc. indifference point, 16s delay0.10.10.20.30.20.00.10.3-0.3-0.50.5
Delay disc. indifference point, 2s delay0.50.62.6-0.11.20.1-0.01.6-0.6-0.10.1
Delay disc. indifference point, 24s delay0.10.10.20.50.5-0.0-0.10.4-0.5-0.20.2
Delay disc. indifference point, 4s delay0.70.82.2-0.71.51.00.01.20.20.8-0.8
Delay disc. indifference point, 8s delay1.61.76.3-0.52.51.51.41.5-0.70.0-0.0
Indifference point function ln k2.02.88.4-2.90.11.4-1.00.62.41.6-1.6
Indifference point function log k2.02.88.4-2.90.11.4-1.00.62.41.6-1.6
Patch foraging total patch changes 0 sec0.20.41.2-1.10.10.3-0.60.70.70.4-0.4
Patch foraging total patch changes 12 sec0.91.13.71.9-0.5-1.10.3-0.6-1.3-0.90.9
Patch foraging total patch changes 18 sec0.20.30.60.5-0.4-0.40.3-0.5-0.4-0.80.8
Patch foraging total patch changes 24 sec0.70.92.70.40.3-0.9-1.61.6-0.30.7-0.7
Patch foraging total patch changes 6 sec0.30.51.40.4-0.1-0.6-1.20.60.10.9-0.9
Patch foraging time to switch 0 sec0.30.52.30.5-1.1-0.3-0.3-1.50.40.2-0.2
Patch foraging water rate 0 sec0.91.56.0-1.81.40.8-0.02.40.30.2-0.2
Patch foraging water rate 12 sec2.13.37.4-2.71.51.3-1.22.31.61.7-1.7
Patch foraging water rate 18 sec1.01.46.5-0.70.0-1.0-1.72.50.00.2-0.2
Patch foraging water rate 24 sec0.71.02.4-1.1-0.1-0.2-1.61.30.91.0-1.0
Patch foraging water rate 6 sec1.62.34.7-2.21.71.4-0.51.91.21.4-1.4
Seeking ratio, delayed vs. immediate footshock2.42.76.8-1.52.42.61.20.40.91.5-1.5
Distance traveled before self-admin1.21.32.8-1.40.71.70.3-0.21.31.3-1.3
Distance traveled after self-admin1.41.64.0-1.52.02.01.20.50.60.5-0.5
Extensor digitorum longus weight0.52.28.2-0.62.91.30.52.2-0.50.9-0.9
Bone: elastic displacement0.40.51.10.8-0.1-1.0-0.20.6-0.9-0.70.7
Bone: elastic work0.10.10.40.1-0.3-0.6-0.30.3-0.2-0.40.4
Bone: endosteal estimation1.94.211.8-2.23.03.42.10.41.01.2-1.2
Bone: endosteal perimeter1.02.26.1-1.32.32.51.90.30.40.5-0.5
Epididymis fat weight2.66.015.94.0-1.8-3.5-0.6-0.2-2.9-2.02.0
Delta time in closed arm before/after self-admin1.11.02.30.8-0.6-1.20.40.0-1.1-1.51.5
Delta time in open arm before/after self-admin3.83.66.5-1.1-2.1-0.1-2.5-1.42.62.1-2.1
Diff in mean of infusions in LGA sessions1.61.75.0-1.11.42.22.2-0.90.40.0-0.0
Delay discount exponential model param1.01.04.00.2-2.0-1.0-0.8-1.40.60.1-0.1
Extinction: sum of active levers before priming0.60.61.8-0.5-0.70.70.2-1.31.00.5-0.5
Active lever presses in extinction session 60.80.81.5-1.20.51.0-0.10.01.01.0-1.0
Bone: final force0.10.20.6-0.30.80.50.60.4-0.1-0.20.2
Bone: final moment0.10.20.4-0.10.40.20.60.2-0.2-0.60.6
Food consumed during 24 hour testing period2.42.96.0-2.42.32.52.10.90.5-0.50.5
Glucose0.20.40.9-0.4-0.9-0.4-1.0-0.30.70.4-0.4
Heart weight0.40.62.90.10.6-0.6-0.51.7-0.7-0.30.3
Delay discount hyperbolic model param0.80.93.40.3-1.8-1.0-0.7-1.40.5-0.00.0
Intermittent access intake day 1-15 change0.40.40.80.70.7-0.10.50.0-0.9-0.60.6
Intermittent access intake escalation0.60.51.90.21.40.61.10.1-0.7-0.50.5
Intermittent access intake escalation 20.70.72.7-0.21.71.21.10.1-0.20.1-0.1
Intermitt. access day 1 inactive lever presses0.10.10.30.3-0.5-0.3-0.10.2-0.2-0.10.1
Intermitt. access day 15 inactive lever presses2.12.35.42.3-0.4-1.60.60.2-2.2-1.61.6
Intermitt. access escalation Index1.91.63.6-0.91.91.01.61.0-0.6-1.31.3
Intermittent access day 1 total infusions1.51.74.01.3-2.0-1.10.4-1.8-0.5-1.31.3
Intermittent access day 15 total infusions1.21.42.11.3-0.5-0.31.3-1.5-1.1-1.41.4
Intermittent access terminal intake (last 3 days)1.11.23.10.90.00.11.8-1.1-1.0-1.41.4
Intermittent access total infusions1.21.34.20.7-1.4-0.21.2-2.1-0.3-1.11.1
Intermittent access day 1 locomotion2.52.74.62.2-1.7-1.70.5-1.4-1.5-1.81.8
Intermittent access day 15 total locomotion0.80.91.31.2-1.1-0.80.4-0.8-0.8-1.11.1
Intermittent access total locomotion0.30.40.80.4-0.9-0.10.6-0.8-0.2-0.60.6
Intermittent access standard deviation1.31.43.91.40.30.22.0-1.1-1.3-1.01.0
Left kidney weight0.30.91.90.21.40.10.91.4-1.2-0.90.9
Right kidney weight0.20.71.60.51.30.31.00.8-1.1-0.50.5
Cocaine induced anxiety0.20.21.20.4-0.30.20.4-1.10.10.4-0.4
Post-drug Anxiety0.70.81.51.1-1.2-0.7-0.7-1.10.10.7-0.7
Baseline Anxiety1.01.02.81.0-1.1-1.7-1.70.6-0.4-0.20.2
Tail length0.30.82.41.01.1-0.3-0.31.5-1.10.4-0.4
Length with tail0.41.33.20.61.80.21.01.7-1.5-0.60.6
Length without tail1.12.48.1-0.51.61.22.80.2-1.0-1.81.8
Times rat made contact with spout0.81.02.0-1.41.31.41.20.60.3-0.30.3
Lifetime Intake1.71.95.01.4-1.8-0.71.0-2.2-0.6-1.31.3
Liver weight, left0.10.20.6-0.40.80.30.50.6-0.2-0.40.4
Liver weight, right0.60.92.60.81.2-0.50.31.6-1.3-0.70.7
Locomotor activity0.10.20.6-0.20.60.30.70.0-0.4-0.60.6
Locomotor testing distance0.10.21.1-1.00.20.2-0.20.50.40.0-0.0
Locomotor testing rearing0.20.41.3-1.1-0.10.0-0.70.70.60.4-0.4
Locomotion in novel chamber0.10.20.60.2-0.8-0.4-0.1-0.3-0.0-0.40.4
Locomotion in novel chamber post-restriction0.10.10.50.2-0.4-0.7-0.50.3-0.2-0.20.2
Fecal boli incidents, locomotor time 12.02.26.61.01.90.82.60.2-1.8-1.21.2
Change in fecal boli incidents, locomotor task3.93.69.2-2.8-1.01.1-1.5-0.73.01.9-1.9
Time >=10cm from walls, locomotor time 10.40.51.5-0.10.61.11.2-0.70.10.2-0.2
Bouts of movement, locomotor time 10.40.51.11.00.9-0.00.60.5-1.0-0.50.5
Total resting periods, locomotor time 10.30.30.60.60.70.10.60.3-0.7-0.40.4
Rest time, locomotor task time 10.50.51.6-1.10.70.40.21.30.1-0.50.6
Distance moved, locomotor task time 10.40.41.10.8-0.6-0.9-1.00.1-0.20.5-0.5
Vertical activity count, locomotor time 10.20.20.50.7-0.5-0.4-0.5-0.2-0.20.3-0.3
Time >=10cm from walls, locomotor time 20.60.61.40.4-0.2-0.21.0-0.4-0.6-1.21.2
Bouts of movement, locomotor time 21.31.43.92.00.2-1.4-0.00.7-1.7-0.90.9
Total resting periods, locomotor time 20.91.02.81.70.2-1.10.10.6-1.5-0.80.8
Rest time, locomotor task time 20.50.61.30.3-1.2-1.0-0.1-0.5-0.2-1.01.0
Distance moved, locomotor task time 20.60.71.40.10.5-0.0-1.11.00.21.2-1.2
Vertical activity count, locomotor time 20.00.00.20.10.40.20.00.3-0.20.1-0.1
Light reinforcement 11.52.78.10.72.90.61.81.8-2.0-1.01.0
Light reinforcement 21.01.44.50.3-0.60.41.8-2.1-0.1-1.21.2
Bone: marrow area1.94.211.8-2.22.93.42.20.31.01.1-1.1
Bone: maximum diameter2.34.311.9-2.62.93.42.30.71.00.6-0.6
Bone: maximum force0.30.51.5-0.51.21.01.00.3-0.1-0.20.2
Bone: maximum moment0.20.41.0-0.40.90.71.00.1-0.2-0.50.5
Mean time between licks in bursts0.60.81.71.1-0.4-0.40.9-1.3-0.7-1.01.0
Mean num. licks in bursts0.50.61.30.1-0.7-1.1-0.50.9-0.5-1.01.0
Cd content in liver0.40.41.40.51.0-0.2-0.21.2-0.70.3-0.3
Co content in liver2.12.45.71.90.6-1.30.81.2-2.4-1.71.7
Cu content in liver0.81.01.71.0-0.3-1.20.10.6-1.3-1.31.3
Fe content in liver2.93.57.1-1.7-0.31.4-1.3-0.92.52.7-2.7
K content in liver0.20.20.4-0.60.10.1-0.60.60.40.6-0.6
Mg content in liver0.50.51.8-0.81.20.6-0.11.30.00.3-0.3
Mn content in liver1.01.23.10.2-0.90.21.5-1.8-0.2-1.31.3
Na content in liver0.80.81.6-0.5-0.21.10.3-1.31.01.1-1.1
Rb content in liver1.72.13.5-1.61.20.8-1.31.91.01.7-1.7
Se content in liver0.60.72.60.6-1.6-0.6-0.1-1.50.2-0.20.2
Sr content in liver0.60.61.80.80.70.61.4-0.7-0.7-0.30.3
Zn content in liver0.91.02.10.9-0.1-0.80.70.2-1.3-1.51.5
Bone: minimum diameter0.30.51.5-0.10.50.41.2-0.1-0.5-1.11.1
Time in familiar zone, hab. session 10.90.92.4-0.31.31.61.5-0.60.10.2-0.2
Time in novel zone, hab. session 11.11.02.4-0.3-0.8-1.5-1.51.5-0.1-0.50.5
Total zone transitions, hab. session 10.81.14.32.1-0.6-1.4-1.0-0.3-0.90.4-0.4
Total locomotion distance, hab. session 11.21.74.62.2-0.9-1.9-1.70.2-0.90.5-0.5
Locomotion velocity, hab. session 10.81.13.71.9-0.7-1.4-1.2-0.3-0.70.5-0.5
Time in familiar zone, hab. session 20.50.51.5-1.20.30.5-0.60.60.90.6-0.6
Time in novel zone, hab. session 20.10.10.20.0-0.4-0.10.3-0.4-0.1-0.40.4
Total zone transitions, hab. session 20.91.25.42.30.5-1.0-0.30.4-1.50.4-0.4
Total locomotion distance, hab. session 21.41.88.62.90.3-1.4-0.10.1-2.0-0.00.0
Locomotion velocity, hab. session 21.62.210.13.20.0-1.50.1-0.4-2.1-0.30.3
Novel to familiar place preference ratio0.20.20.7-0.10.80.40.50.4-0.3-0.30.3
Novelty place preference0.40.51.4-0.41.20.70.90.6-0.3-0.40.4
Time in novel zone, NPP test0.70.71.8-1.11.31.00.70.90.1-0.20.2
Total zone transitions, NPP test0.30.50.90.90.5-0.4-0.70.6-0.50.9-0.9
Total locomotion distance, NPP test0.50.72.81.70.6-0.6-0.40.3-1.10.6-0.6
Locomotion velocity, NPP test0.71.04.92.20.2-0.8-0.4-0.4-1.10.7-0.7
Intraocular pressure0.40.63.1-0.70.4-0.4-1.01.70.10.1-0.1
Delta distance traveled before/after self-admin0.70.71.7-0.41.30.20.71.1-0.7-0.90.9
Delta ambulatory time before/after self-admin0.50.61.1-0.61.00.30.80.7-0.4-1.01.0
Parametrial fat weight0.10.20.40.6-0.0-0.5-0.60.3-0.30.2-0.2
Pavlov. Cond. lever latency1.51.96.0-1.1-1.7-1.5-2.41.40.9-0.10.1
Pavlov. Cond. magazine entry latency2.63.47.22.70.5-0.12.6-1.8-2.2-1.51.5
Pavlov. Cond. change in total contacts2.02.24.82.10.80.12.2-1.0-2.0-1.11.1
Pavlov. Cond. index score2.12.76.62.41.00.52.6-1.7-1.9-0.80.8
Pavlov. Cond. latency score1.72.25.72.11.10.62.4-1.6-1.6-0.60.6
Pavlov. Cond. lever contacts1.31.54.81.21.41.02.2-1.1-1.1-0.30.3
Pavlov. Cond. magazine entry number1.72.15.6-2.4-0.30.2-1.91.61.81.0-1.0
Pavlov. Cond. intertrial magazine entries2.83.46.2-1.40.70.3-2.52.01.52.4-2.4
Pavlov. Cond. lever-magazine prob. diff.2.32.87.32.41.10.52.7-1.8-1.9-0.80.8
Pavlov. Cond. response bias1.51.84.22.10.80.22.0-1.2-1.7-0.80.8
Pavlov. Cond. lever latency1.52.04.32.0-1.7-2.1-0.5-0.7-1.2-1.11.1
Pavlov. Cond. magazine entry latency0.91.14.90.1-1.60.0-0.2-2.20.90.4-0.4
Pavlov. Cond. change in total contacts0.30.51.1-1.00.80.90.00.50.60.5-0.5
Pavlov. Cond. index score0.70.92.2-1.20.61.50.4-0.61.10.9-0.9
Pavlov. Cond. latency score1.11.33.1-1.60.61.80.4-0.71.41.0-1.0
Pavlov. Cond. lever contacts1.41.94.8-1.91.82.20.90.41.00.9-0.9
Pavlov. Cond. magazine entry number0.70.91.90.70.7-0.70.21.4-1.2-1.01.0
Pavlov. Cond. intertrial magazine entries0.50.61.30.80.70.01.10.3-1.1-0.80.8
Pavlov. Cond. lever-magazine prob. diff.0.60.71.8-0.90.41.30.6-0.80.90.7-0.7
Pavlov. Cond. response bias0.50.71.7-0.90.81.30.4-0.30.80.9-0.9
Time in closed arm before self-admin0.40.41.2-0.21.01.01.1-0.30.00.1-0.1
Time in closed arm after self-admin0.70.71.30.9-0.2-0.60.7-0.2-1.0-1.11.1
Time in open arm before self-admin0.60.61.5-0.71.11.01.20.5-0.2-0.50.5
Time in open arm after self-admin2.32.55.9-1.9-0.51.2-1.0-1.02.41.8-1.8
Bone: periosteal estimation1.22.67.1-2.12.22.71.70.40.90.6-0.6
Bone: periosteal perimeter0.91.43.5-1.81.11.90.50.11.20.9-0.9
Bone: post-yield work1.72.45.5-1.82.32.30.70.71.01.3-1.3
Progressive ratio test 1 active lever presses0.91.02.00.7-0.3-0.11.4-0.9-0.8-1.31.3
Progressive ratio test 1 breakpoint1.11.12.60.7-0.40.01.6-1.0-0.8-1.41.4
Progressive ratio test 1 inactive lever presses0.70.81.21.1-0.8-0.40.9-1.1-0.7-1.01.0
Progressive ratio test 2 active lever presses0.80.81.11.0-0.4-0.31.1-1.0-0.9-1.01.0
Progressive ratio test 2 breakpoint0.50.61.10.8-0.4-0.11.0-1.0-0.7-0.80.8
Progressive ratio test 2 inactive lever presses1.51.74.11.2-1.9-0.80.9-2.0-0.6-1.21.2
Incentive Sensitization - Responses0.80.81.51.2-0.5-0.40.9-0.9-1.0-0.90.9
Incentive Sensitization - Breakpoint0.90.92.21.5-0.5-0.70.7-0.7-1.2-0.90.9
Sum of active levers in priming session hrs 5-60.70.72.4-1.50.10.7-0.40.41.10.7-0.7
Progressive ratio1.31.53.80.71.40.41.90.7-1.6-1.21.2
Food seeking constrained by brief footshock3.03.77.3-2.72.72.10.02.51.11.3-1.3
Seeking ratio, punishment vs. effort2.12.54.2-2.00.50.9-1.71.01.91.9-1.9
Retroperitoneal fat weight1.34.310.13.2-0.3-2.60.01.2-3.0-1.81.8
Reaction time number correct0.81.12.5-1.00.40.8-0.9-0.11.21.6-1.6
Reaction time mean minus median0.70.92.01.0-1.3-1.4-0.4-0.6-0.5-1.01.0
Reaction time mean minus median AUC0.40.61.90.4-1.4-1.0-0.6-0.80.1-0.50.5
Reaction time num false alarms0.50.72.40.5-1.6-0.9-1.3-0.40.30.4-0.4
Reaction time num false alarms AUC0.70.93.00.3-1.7-0.9-1.5-0.50.50.6-0.6
Reaction time trials correct on left0.81.12.5-1.00.40.8-0.9-0.11.21.6-1.6
Reaction time trials on left0.81.22.6-0.90.30.7-1.0-0.11.31.6-1.6
Reaction time mean0.71.02.30.9-1.5-1.0-0.0-1.3-0.3-1.01.0
Reaction time mean AUC0.40.61.70.6-1.3-0.8-0.2-1.1-0.1-0.70.7
Median of all reaction times0.71.02.31.0-1.5-0.90.1-1.4-0.3-1.01.0
Reaction time omissions0.91.22.91.1-1.7-1.3-1.6-0.80.20.6-0.6
Reaction time false alarm rate0.60.93.00.8-1.7-1.4-1.0-0.2-0.2-0.30.3
Reaction time premature initiation rate0.30.41.7-0.00.8-0.3-0.41.3-0.5-0.20.2
Reaction time premature initiations0.30.51.5-0.50.90.1-0.91.20.20.6-0.6
Std. dev. reaction times0.81.13.10.9-1.7-1.5-0.8-0.9-0.2-0.70.7
Reaction time trials completed0.81.22.6-0.90.30.7-1.0-0.11.31.6-1.6
Reaction time trials AUC0.91.42.9-1.10.30.9-1.0-0.11.41.7-1.7
Run reversals in cocaine runway, females0.50.51.10.2-1.1-1.0-0.2-0.1-0.3-0.80.8
Run reversals in cocaine runway, males0.80.81.4-0.51.10.9-0.21.00.41.2-1.2
Latency to leave start box in cocaine runway0.40.41.0-0.30.10.80.3-1.00.70.7-0.7
Latency to leave start box in cocaine runway, F0.10.10.40.20.60.50.6-0.2-0.10.1-0.1
Latency to leave start box in cocaine runway, M0.40.41.50.2-1.0-0.1-0.3-1.20.50.5-0.5
Std. dev. time between licks in bursts0.50.61.30.41.21.11.0-0.9-0.10.6-0.6
Total sessions with >9 infusions0.80.92.90.7-0.40.51.4-1.7-0.3-0.70.7
Short access day 1 total inactive lever presses0.30.30.90.4-0.1-0.50.30.3-0.6-0.90.9
Short access day 10 total inactive lever presses0.20.20.3-0.5-0.5-0.1-0.60.20.50.5-0.5
Short access day 1 total infusions1.31.43.31.4-1.1-0.31.3-1.8-0.8-1.11.0
Short access day 10 total infusions1.61.88.20.6-1.90.11.1-2.90.4-0.60.6
Short access total infusions2.52.86.91.8-2.4-1.20.7-2.6-0.7-1.51.5
Short access day 1 locomotion0.40.51.30.70.60.41.2-0.4-0.7-0.60.6
Short access day 10 total locomotion0.10.10.30.00.10.50.5-0.40.1-0.00.0
Short access total locomotion1.31.32.61.2-0.8-0.21.4-1.6-0.8-1.31.3
One hour access (0.3 mA shock)0.60.71.50.8-1.1-0.50.6-1.2-0.4-0.80.8
Compulsive drug intake0.60.62.2-1.5-0.70.5-0.0-0.71.3-0.00.0
One hour access (shock baseline)0.81.02.31.5-0.4-0.11.3-1.5-0.9-0.60.6
Social response proportion0.50.51.4-0.1-1.2-0.80.1-0.5-0.0-0.90.9
Social responses0.50.61.50.70.2-0.11.2-0.7-0.8-0.90.9
Social time0.10.10.4-0.7-0.30.1-0.1-0.20.50.2-0.2
Soleus weight3.510.131.7-2.95.64.31.83.20.62.1-2.1
Bone: stiffness0.30.50.7-0.60.50.3-0.80.80.50.8-0.8
Tibialis anterior weight2.37.714.7-3.63.73.80.82.41.82.3-2.3
Time to tail flick, vehicle, before self-admin1.11.12.0-1.20.71.0-0.60.21.31.4-1.4
Time to tail flick, vehicle, after self-admin2.12.25.5-2.20.72.41.0-0.61.71.2-1.2
Time to tail flick, test, before self-admin0.40.41.10.90.7-0.20.40.6-1.1-0.40.4
Time to tail flick, test, after self-admin0.40.51.3-0.41.20.90.80.7-0.20.2-0.2
Delta time to tail flick, vehicle, before/after SA0.40.41.1-0.90.31.00.7-0.10.50.3-0.3
Delta time to tail flick, test, before/after SA1.11.02.9-1.70.41.40.5-0.21.30.6-0.6
Tibia length1.23.511.7-0.11.21.23.4-0.5-1.3-2.42.4
Ambulatory time before self-admin0.40.41.0-0.10.11.00.7-1.00.50.6-0.6
Ambulatory time after self-admin1.11.33.4-1.61.51.81.00.20.80.4-0.4
Bone: tissue strength0.20.20.6-0.3-0.8-0.6-0.80.00.4-0.00.0
Total heroin consumption1.11.33.0-1.51.71.50.41.10.70.8-0.8
Bone: trabecular number0.30.51.90.3-0.10.60.3-1.40.40.8-0.8
Bone: trabecular spacing1.52.05.01.9-1.2-2.2-0.80.3-1.4-1.21.2
Bone: trabecular thickness0.20.20.6-0.5-0.00.10.50.2-0.0-0.80.8
Bone: trabecular tissue density0.40.61.4-0.1-0.4-0.9-0.21.0-0.5-1.21.2
Water consumed over 24 hours1.11.32.8-1.51.71.71.40.70.2-0.20.2
Number of responses in last shaping day2.62.711.4-0.41.32.03.4-1.3-0.5-1.11.1