Map1s

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Map1s	0.09	0.05	1.2e-03	0.01	0.05	0.04	0.03	9.6e-02	3.3e-03	1.4e-02	1.5e-02
2	Liver	gene expression	Map1s	0.63	0.13	0.0e+00	0.24	0.28	0.27	0.26	1.8e-26	3.7e-31	1.3e-29	9.2e-29
3	pVTA	gene expression	Map1s	0.09	0.05	1.6e-08	0.1	0.11	0.1	0.1	1.3e-08	4.5e-09	1.1e-08	9.7e-09
4	Brain	gene expression	Map1s	0.08	0.04	6.7e-09	0.1	0.1	0.1	0.1	8.3e-10	1.4e-09	6.9e-10	5.1e-10
5	NAcc	gene expression	Map1s	0.06	0.03	4.5e-11	0.07	0.07	0.06	0.06	2.7e-10	1.1e-10	6.0e-09	1.5e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.9	1.6	3.6	-1.9	1.5	-0.7	-1.2	-0.3
Area under the delay curve	0.1	0.1	0.5	0.7	-0.2	0.0	-0.0	-0.1
BMI with tail	1.5	5.2	8.8	-3.0	2.8	-1.9	-1.9	-1.6
BMI without tail	3.1	9.3	13.2	-3.3	3.6	-2.8	-2.8	-2.6
Body weight	5.0	21.8	35.7	-6.0	5.3	-4.0	-4.2	-3.4
Weight adjusted by age	1.9	2.8	3.8	-1.9	1.7	-1.6	-1.6	-1.5
Bone surface	0.3	0.6	1.9	-1.4	0.8	-0.1	-0.4	0.2
Bone volume	1.0	1.7	4.0	-2.0	1.6	-0.8	-1.1	-0.5
Breakpoint value in progressive ratio session	0.1	0.2	0.3	-0.4	-0.2	0.5	0.3	0.5
Number of licking bursts	0.1	0.1	0.2	0.4	-0.3	0.2	0.3	0.2
Context. condit. distance diff. score	0.1	0.1	0.1	-0.4	0.1	-0.2	-0.4	-0.1
Locomotion velocity, session 1	1.0	1.1	1.9	-0.5	-0.6	1.2	1.1	1.4
Locomotion distance, session 1	2.4	3.0	4.7	0.6	-1.6	2.0	1.9	2.2
Locomotion velocity, session 2	1.2	1.4	2.7	-1.6	1.4	-0.9	-1.0	-0.8
Locomotion distance, session 2	2.6	3.6	5.4	0.9	-1.7	2.2	2.0	2.3
Locomotion velocity, session 3	0.1	0.2	0.4	0.2	-0.2	0.5	0.3	0.6
Locomotion distance, session 3	0.6	0.6	1.1	0.2	-0.8	0.9	0.7	1.0
Stereotopy head waving bouts, day 3	0.1	0.2	0.4	0.0	-0.4	0.5	0.3	0.6
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.3	-0.0	-0.0	-0.1	0.1
Locomotion velocity, session 7	1.4	1.6	2.2	1.3	-1.5	1.1	1.3	1.0
Locomotion distance, session 7	1.7	2.2	3.3	1.8	-1.6	1.3	1.4	1.1
Stereotopy head waving bouts, day 7	0.4	0.5	1.8	-1.3	0.5	-0.2	-0.4	0.2
Stereotopy head waving duration, day 7	1.1	1.3	3.0	-1.7	1.2	-0.8	-1.1	-0.5
Locomotion velocity, session 8	1.1	1.4	2.3	0.2	-1.0	1.4	1.2	1.5
Locomotion distance, session 8	0.9	1.2	2.4	0.0	-0.9	1.3	1.1	1.5
Degree of sensitization distance	0.4	0.5	1.5	1.2	-0.6	0.3	0.6	0.1
Degree of sensitization stereotypy	0.6	0.6	2.3	-1.5	0.7	-0.4	-0.5	-0.1
Conditioned locomotion	0.0	0.1	0.2	0.3	-0.4	0.0	0.1	0.0
Cocaine response after cond. corrected	0.6	0.7	1.2	0.6	0.2	-0.9	-1.0	-1.1
Cocaine response after cond. not corrected	0.2	0.2	0.8	0.9	-0.2	-0.2	-0.3	-0.4
Cocaine response before conditioning	1.4	1.6	2.4	0.6	-0.9	1.5	1.5	1.6
Saline control response	0.2	0.3	0.6	-0.4	0.0	0.6	0.4	0.8
Bone: connectivity density	0.4	0.6	1.5	-1.2	0.9	-0.3	-0.7	-0.0
Bone: cortical apparent density	0.1	0.1	0.2	0.4	0.0	0.5	0.2	0.4
Bone: cortical area	6.2	9.5	15.0	-3.9	3.3	-2.9	-2.8	-2.4
Bone: cortical porosity	0.5	0.5	0.9	0.0	-0.7	0.8	1.0	0.9
Bone: cortical porosity	0.5	0.5	0.8	-0.1	-0.6	0.8	0.9	0.9
Bone: cortical thickness	4.3	7.1	13.8	-3.7	2.8	-2.3	-2.4	-1.8
Bone: cortical thickness	2.3	2.7	5.4	-2.3	1.4	-1.5	-1.6	-1.1
Bone: cortical tissue density	0.1	0.2	0.4	0.5	-0.1	0.6	0.3	0.5
Condit. Reinf. active minus inactive responses	0.4	0.4	1.8	-1.3	0.3	-0.3	-0.4	-0.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	-0.8	0.2	-0.5	-0.4	-0.3
Condit. Reinf. active responses	0.5	0.7	2.6	-1.6	0.6	-0.4	-0.5	-0.1
Condit. Reinf. inactive responses	0.2	0.3	0.6	-0.8	0.6	-0.3	-0.4	-0.3
Incentive salience index mean	0.8	0.9	3.9	-2.0	0.7	-0.2	-0.4	0.2
Condit. Reinf. lever presses	1.0	1.4	5.8	-2.4	1.0	0.0	-0.3	0.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	0.0	-0.3	0.6	0.7	0.7
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.7	-0.9	0.6	-0.6	-0.5	-0.4
Condit. Reinf. active responses	1.1	1.6	2.0	1.0	-1.0	1.4	1.4	1.4
Condit. Reinf. inactive responses	2.5	3.3	4.6	2.1	-1.7	1.8	1.8	1.5
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.1	0.5	-0.2	-0.1	-0.2
Condit. Reinf. lever reinforcers received	0.3	0.4	0.6	0.6	-0.4	0.7	0.8	0.6
Conditioned reinforcement - actives	1.3	2.1	2.6	-1.1	1.4	-1.6	-1.4	-1.6
Conditioned reinforcement - inactives	7.2	10.6	12.4	-3.0	3.1	-3.5	-3.2	-3.4
Conditioned locomotion	1.8	2.4	3.4	-0.9	1.5	-1.7	-1.6	-1.8
Patch foraging indifference point 0 sec	2.5	4.5	5.6	-2.4	2.3	-1.9	-2.2	-1.8
Patch foraging indifference point AUC	0.1	0.1	0.2	0.4	0.5	0.2	-0.2	-0.0
Delay disc. indifference point, 0s delay	2.2	2.4	3.3	1.8	-1.5	1.5	1.5	1.3
Delay disc. indifference point, 16s delay	0.9	1.0	3.5	1.9	-0.9	0.5	0.6	0.1
Delay disc. indifference point, 2s delay	0.7	0.8	1.1	0.6	-1.0	1.0	0.7	1.0
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	0.2	0.5	-0.6	-0.5	-0.8
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.2	0.1	0.3	0.0	0.4
Delay disc. indifference point, 8s delay	0.3	0.4	0.8	0.4	0.3	-0.7	-0.7	-0.9
Indifference point function ln k	0.3	0.4	0.8	-0.8	0.2	-0.9	-0.4	-0.8
Indifference point function log k	0.3	0.4	0.8	-0.8	0.2	-0.9	-0.4	-0.8
Patch foraging total patch changes 0 sec	3.7	6.9	7.8	-2.8	2.8	-2.5	-2.7	-2.3
Patch foraging total patch changes 12 sec	1.3	1.6	2.9	-1.0	1.7	-1.1	-1.4	-1.1
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.3	0.3	0.1	-0.2	-0.0
Patch foraging total patch changes 24 sec	0.3	0.5	0.7	-0.9	0.8	-0.6	-0.8	-0.5
Patch foraging total patch changes 6 sec	1.9	3.0	4.2	-1.8	2.1	-1.4	-1.9	-1.3
Patch foraging time to switch 0 sec	0.9	1.9	2.4	1.2	-1.0	1.6	1.5	1.5
Patch foraging water rate 0 sec	0.9	2.0	3.0	-1.7	1.3	-1.3	-1.4	-1.2
Patch foraging water rate 12 sec	0.2	0.4	0.6	-0.8	0.4	-0.7	-0.4	-0.6
Patch foraging water rate 18 sec	0.3	0.5	0.8	0.1	-0.9	0.7	0.8	0.8
Patch foraging water rate 24 sec	0.2	0.3	1.3	-1.1	0.2	-0.1	0.0	0.2
Patch foraging water rate 6 sec	1.0	1.5	2.1	-1.1	0.9	-1.4	-1.2	-1.4
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	1.0	0.8	-0.5	0.9	1.0	0.8
Distance traveled before self-admin	0.8	1.1	1.7	-1.3	1.2	-0.8	-1.0	-0.7
Distance traveled after self-admin	1.1	1.4	3.1	-1.8	1.3	-0.9	-1.0	-0.7
Extensor digitorum longus weight	0.5	1.9	3.3	-1.8	1.8	-1.0	-1.2	-0.8
Bone: elastic displacement	0.4	0.5	1.0	-0.0	-0.6	0.8	0.7	1.0
Bone: elastic work	1.8	2.4	3.7	-1.9	1.7	-1.4	-1.5	-1.1
Bone: endosteal estimation	0.1	0.2	0.6	0.4	0.1	-0.5	-0.2	-0.8
Bone: endosteal perimeter	0.7	1.4	2.4	-0.9	0.9	-1.5	-0.9	-1.5
Epididymis fat weight	0.5	1.8	3.2	-1.8	1.7	-1.0	-1.1	-0.9
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	0.3	0.3	-0.4	-0.5	-0.5
Delta time in open arm before/after self-admin	0.8	0.8	1.0	0.7	-0.7	1.0	1.0	1.0
Diff in mean of infusions in LGA sessions	1.1	1.4	2.2	-1.1	1.5	-1.0	-1.2	-1.0
Delay discount exponential model param	0.1	0.1	0.1	-0.3	-0.0	0.2	0.3	0.3
Extinction: sum of active levers before priming	1.0	1.1	2.0	0.2	-0.7	1.3	1.1	1.4
Active lever presses in extinction session 6	0.1	0.1	0.2	0.4	-0.4	0.4	0.4	0.4
Bone: final force	7.6	12.1	14.6	-3.8	3.7	-3.4	-3.3	-3.1
Bone: final moment	7.0	11.3	12.5	-3.5	3.5	-3.4	-3.2	-3.2
Food consumed during 24 hour testing period	0.7	0.9	1.8	0.0	-0.6	1.1	1.0	1.3
Glucose	1.2	1.9	2.4	-1.5	1.6	-1.3	-1.2	-1.2
Heart weight	1.4	2.2	5.8	-2.4	1.2	-1.3	-1.2	-0.8
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.2	-0.0	0.1	0.3	0.2
Intermittent access intake day 1-15 change	0.1	0.1	0.5	-0.7	0.3	-0.3	-0.2	-0.1
Intermittent access intake escalation	0.0	0.0	0.2	-0.4	0.0	0.0	-0.0	0.2
Intermittent access intake escalation 2	0.3	0.4	0.6	-0.7	0.8	-0.5	-0.6	-0.5
Intermitt. access day 1 inactive lever presses	0.1	0.4	0.5	-0.6	0.6	-0.7	-0.5	-0.6
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	0.1	-0.3	-0.1	0.3	-0.1
Intermitt. access escalation Index	0.5	0.7	1.2	1.1	-1.0	0.7	0.9	0.6
Intermittent access day 1 total infusions	0.9	1.5	2.5	-0.3	1.0	-1.4	-1.3	-1.6
Intermittent access day 15 total infusions	0.2	0.3	0.4	-0.3	0.4	-0.6	-0.6	-0.7
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.5	-0.1	0.4	-0.6	-0.5	-0.7
Intermittent access total infusions	1.4	1.7	2.5	-0.6	1.2	-1.5	-1.4	-1.6
Intermittent access day 1 locomotion	2.0	2.6	3.3	-1.0	1.6	-1.7	-1.8	-1.8
Intermittent access day 15 total locomotion	0.1	0.2	0.2	-0.2	0.3	-0.4	-0.5	-0.5
Intermittent access total locomotion	2.2	2.6	3.3	-1.2	1.7	-1.6	-1.8	-1.7
Intermittent access standard deviation	0.2	0.4	0.6	-0.3	0.7	-0.7	-0.5	-0.8
Left kidney weight	0.5	2.3	4.6	-2.1	2.0	-1.0	-1.3	-0.8
Right kidney weight	1.2	5.4	8.8	-3.0	2.9	-1.7	-2.0	-1.5
Cocaine induced anxiety	1.3	1.9	2.3	-1.3	1.4	-1.3	-1.5	-1.3
Post-drug Anxiety	0.0	0.0	0.1	-0.2	0.3	-0.2	-0.1	-0.2
Baseline Anxiety	2.9	3.4	4.1	1.8	-1.8	1.8	2.0	1.8
Tail length	1.0	3.8	5.3	-2.3	2.3	-1.7	-1.8	-1.5
Length with tail	2.0	8.9	15.2	-3.9	3.3	-2.5	-2.8	-2.1
Length without tail	1.6	5.1	10.0	-3.2	2.3	-1.9	-2.1	-1.5
Times rat made contact with spout	0.3	0.4	0.6	0.5	-0.4	0.7	0.8	0.7
Lifetime Intake	2.4	2.9	3.9	-1.1	1.6	-1.9	-1.8	-2.0
Liver weight, left	0.6	0.9	1.9	0.0	-0.5	1.2	1.0	1.4
Liver weight, right	1.1	1.9	3.4	-1.6	1.9	-1.1	-1.2	-1.0
Locomotor activity	0.4	0.7	1.3	-1.1	0.1	0.8	0.4	1.1
Locomotor testing distance	0.4	0.7	1.5	-0.2	-0.4	1.0	0.8	1.2
Locomotor testing rearing	0.5	1.1	2.4	-0.0	-0.5	1.4	0.9	1.6
Locomotion in novel chamber	0.1	0.1	0.4	-0.6	0.4	0.0	-0.2	0.2
Locomotion in novel chamber post-restriction	0.3	0.5	0.9	-0.9	-0.4	0.6	0.5	1.0
Fecal boli incidents, locomotor time 1	0.2	0.3	1.0	1.0	-0.5	0.3	0.3	0.1
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	0.7	-0.6	0.4	0.5	0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.5	0.1	0.0	-0.2	-0.1
Bouts of movement, locomotor time 1	0.5	0.6	0.9	0.6	-0.6	0.9	0.9	0.8
Total resting periods, locomotor time 1	1.2	1.3	1.6	1.1	-1.0	1.2	1.3	1.1
Rest time, locomotor task time 1	0.1	0.1	0.4	0.6	-0.2	-0.1	0.1	-0.2
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.1	-0.0	0.1	0.1	0.1
Vertical activity count, locomotor time 1	0.0	0.1	0.3	-0.5	0.2	0.3	0.1	0.4
Time >=10cm from walls, locomotor time 2	0.5	0.7	1.7	1.3	-0.9	0.6	0.7	0.5
Bouts of movement, locomotor time 2	0.1	0.2	0.4	-0.3	-0.1	0.5	0.3	0.6
Total resting periods, locomotor time 2	0.0	0.1	0.2	-0.4	-0.0	0.3	0.2	0.4
Rest time, locomotor task time 2	0.4	0.5	0.6	-0.8	0.7	-0.8	-0.7	-0.7
Distance moved, locomotor task time 2	0.2	0.2	0.7	0.8	-0.5	0.1	0.3	0.0
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.2	0.1	-0.0	-0.1	0.1
Light reinforcement 1	0.0	0.1	0.2	0.5	-0.1	-0.2	-0.3	-0.4
Light reinforcement 2	0.6	1.0	1.8	0.6	0.7	-1.0	-1.1	-1.4
Bone: marrow area	0.1	0.2	0.4	0.5	0.0	-0.4	-0.1	-0.6
Bone: maximum diameter	2.6	4.9	6.2	-2.5	2.1	-2.3	-2.0	-2.1
Bone: maximum force	6.2	11.1	17.3	-4.2	3.6	-3.1	-3.0	-2.7
Bone: maximum moment	5.3	9.4	13.7	-3.7	3.2	-3.0	-2.8	-2.6
Mean time between licks in bursts	1.3	3.3	4.0	-2.0	1.8	-1.9	-1.6	-1.7
Mean num. licks in bursts	0.0	0.0	0.1	-0.3	0.0	0.1	0.1	0.2
Cd content in liver	1.6	1.7	2.7	-1.0	0.9	-1.6	-1.3	-1.6
Co content in liver	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.0	-0.0
Cu content in liver	2.0	2.4	3.9	0.4	-1.6	1.7	1.6	2.0
Fe content in liver	0.7	0.8	1.4	1.2	-0.8	0.9	0.8	0.7
K content in liver	2.4	2.3	3.5	1.8	-1.9	1.2	1.5	1.1
Mg content in liver	0.1	0.1	0.4	0.3	-0.7	0.2	0.3	0.2
Mn content in liver	0.1	0.1	0.2	-0.3	-0.4	-0.1	0.1	0.0
Na content in liver	3.5	3.7	4.5	1.5	-1.9	2.1	2.0	2.1
Rb content in liver	2.2	2.5	4.0	-0.9	1.0	-2.0	-1.7	-2.0
Se content in liver	0.4	0.4	0.7	0.1	-0.8	0.7	0.7	0.8
Sr content in liver	0.4	0.3	0.6	0.8	-0.5	0.6	0.6	0.4
Zn content in liver	0.1	0.1	0.2	0.1	-0.1	0.4	0.3	0.4
Bone: minimum diameter	1.8	3.3	4.4	-2.0	2.1	-1.7	-1.6	-1.6
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.3	0.5	-0.2	-0.3	-0.2
Time in novel zone, hab. session 1	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.1	-0.0
Total zone transitions, hab. session 1	0.8	1.1	1.6	0.5	-0.9	1.2	1.1	1.3
Total locomotion distance, hab. session 1	2.2	3.1	4.4	0.9	-1.7	2.0	1.9	2.1
Locomotion velocity, hab. session 1	2.2	3.2	4.2	1.0	-1.7	2.0	1.9	2.0
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.1	0.3	-0.2	-0.2	-0.3
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.2
Total zone transitions, hab. session 2	0.3	0.3	0.7	0.3	-0.8	0.5	0.6	0.6
Total locomotion distance, hab. session 2	0.7	0.9	1.4	-0.2	-1.0	1.0	1.0	1.2
Locomotion velocity, hab. session 2	0.9	1.2	1.9	-0.0	-1.1	1.1	1.2	1.4
Novel to familiar place preference ratio	0.3	0.3	0.5	0.3	0.5	-0.5	-0.6	-0.7
Novelty place preference	0.2	0.2	0.4	0.5	0.2	-0.4	-0.4	-0.6
Time in novel zone, NPP test	0.1	0.1	0.6	0.7	-0.1	-0.1	-0.0	-0.3
Total zone transitions, NPP test	1.2	1.8	2.4	0.6	-1.5	1.4	1.4	1.6
Total locomotion distance, NPP test	2.5	3.4	5.1	0.7	-1.9	2.0	1.9	2.3
Locomotion velocity, NPP test	2.3	3.2	4.6	0.8	-1.9	2.0	1.9	2.1
Intraocular pressure	1.9	2.7	3.2	-1.3	1.5	-1.8	-1.8	-1.8
Delta distance traveled before/after self-admin	0.5	0.5	1.0	-1.0	0.8	-0.5	-0.6	-0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.5	0.3	-0.2	-0.2	-0.2
Parametrial fat weight	3.3	7.8	10.7	-1.6	2.9	-3.0	-2.8	-3.3
Pavlov. Cond. lever latency	0.7	0.8	2.6	1.6	-0.7	-0.5	-0.1	-0.9
Pavlov. Cond. magazine entry latency	0.3	0.4	1.0	-0.6	1.0	-0.4	-0.6	-0.3
Pavlov. Cond. change in total contacts	1.7	1.8	4.1	-2.0	1.7	-0.8	-1.1	-0.5
Pavlov. Cond. index score	0.3	0.4	0.8	-0.9	0.6	0.4	0.1	0.7
Pavlov. Cond. latency score	0.4	0.5	1.1	-1.0	0.6	0.6	0.2	0.9
Pavlov. Cond. lever contacts	0.6	0.7	2.3	-1.5	0.9	0.3	-0.1	0.6
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	0.8	-1.0	0.4	0.6	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.6	-0.7	-0.6	0.3	0.3	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.7	-0.9	0.6	0.3	0.0	0.5
Pavlov. Cond. response bias	0.3	0.4	1.0	-1.0	0.8	-0.1	-0.3	0.0
Pavlov. Cond. lever latency	1.1	1.5	2.8	1.2	-1.7	1.0	1.1	0.9
Pavlov. Cond. magazine entry latency	1.1	1.3	2.8	-1.2	1.7	-0.8	-1.0	-0.8
Pavlov. Cond. change in total contacts	1.0	1.6	2.7	-1.4	1.6	-1.0	-1.2	-0.9
Pavlov. Cond. index score	1.7	2.3	4.1	-1.5	2.0	-1.3	-1.4	-1.2
Pavlov. Cond. latency score	1.1	1.5	3.2	-1.3	1.8	-0.9	-1.1	-0.9
Pavlov. Cond. lever contacts	0.9	1.2	2.4	-1.2	1.6	-0.8	-1.0	-0.8
Pavlov. Cond. magazine entry number	2.4	2.9	5.2	1.7	-2.3	1.4	1.6	1.4
Pavlov. Cond. intertrial magazine entries	1.6	2.4	4.0	1.5	-2.0	1.3	1.6	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.5	4.5	-1.6	2.1	-1.3	-1.5	-1.2
Pavlov. Cond. response bias	1.3	1.7	3.1	-1.4	1.8	-1.1	-1.2	-1.1
Time in closed arm before self-admin	6.3	8.1	9.1	-3.0	3.0	-2.8	-2.8	-2.6
Time in closed arm after self-admin	6.2	6.6	8.3	-1.7	2.5	-2.8	-2.7	-2.9
Time in open arm before self-admin	1.6	1.8	3.2	0.3	-1.1	1.6	1.3	1.8
Time in open arm after self-admin	3.3	3.6	6.6	0.3	-1.5	2.3	2.0	2.6
Bone: periosteal estimation	1.6	3.4	3.8	-1.9	1.8	-1.9	-1.6	-1.8
Bone: periosteal perimeter	4.4	7.6	9.0	-3.0	2.7	-2.9	-2.5	-2.7
Bone: post-yield work	0.1	0.2	0.4	0.1	-0.6	0.3	0.5	0.4
Progressive ratio test 1 active lever presses	2.8	3.4	3.9	-1.9	1.9	-1.8	-2.0	-1.7
Progressive ratio test 1 breakpoint	2.5	3.1	3.5	-1.8	1.8	-1.7	-1.9	-1.6
Progressive ratio test 1 inactive lever presses	1.3	1.9	2.3	-1.5	1.5	-1.4	-1.4	-1.3
Progressive ratio test 2 active lever presses	1.0	1.1	1.7	-0.5	1.0	-1.2	-1.2	-1.3
Progressive ratio test 2 breakpoint	0.7	0.8	1.2	-0.4	0.8	-1.0	-1.0	-1.1
Progressive ratio test 2 inactive lever presses	1.0	1.6	2.0	-1.2	1.1	-1.4	-1.2	-1.4
Incentive Sensitization - Responses	0.2	0.3	1.0	1.0	-0.1	-0.4	-0.1	-0.6
Incentive Sensitization - Breakpoint	0.3	0.4	1.5	1.2	-0.3	-0.1	0.1	-0.4
Sum of active levers in priming session hrs 5-6	4.6	4.3	5.3	1.7	-2.3	2.1	2.1	2.1
Progressive ratio	0.0	0.1	0.2	0.4	-0.3	-0.1	0.2	-0.2
Food seeking constrained by brief footshock	0.3	0.3	0.8	0.4	-0.9	0.4	0.5	0.4
Seeking ratio, punishment vs. effort	0.3	0.4	0.8	0.1	-0.7	0.7	0.6	0.9
Retroperitoneal fat weight	2.7	11.4	12.3	-3.2	3.5	-3.5	-3.3	-3.4
Reaction time number correct	0.5	1.0	1.9	-0.4	-0.6	1.2	1.1	1.4
Reaction time mean minus median	0.0	0.0	0.1	-0.0	-0.0	0.3	0.1	0.2
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.2	-0.1	0.0	-0.0	0.0
Reaction time num false alarms	0.9	1.2	1.7	-1.1	1.0	-1.1	-1.3	-1.0
Reaction time num false alarms AUC	0.6	0.9	1.3	-0.9	0.8	-1.0	-1.2	-0.9
Reaction time trials correct on left	0.5	1.0	1.9	-0.4	-0.6	1.2	1.1	1.4
Reaction time trials on left	0.5	0.9	1.8	-0.5	-0.5	1.1	1.0	1.3
Reaction time mean	1.0	1.5	2.6	-0.3	1.1	-1.4	-1.3	-1.6
Reaction time mean AUC	0.4	0.6	1.3	0.3	0.5	-0.8	-0.8	-1.1
Median of all reaction times	1.4	2.0	3.7	-0.1	1.1	-1.6	-1.5	-1.9
Reaction time omissions	1.0	1.4	1.8	-1.3	1.3	-1.0	-1.2	-1.0
Reaction time false alarm rate	1.3	1.8	2.6	-0.9	1.1	-1.5	-1.6	-1.5
Reaction time premature initiation rate	0.5	0.7	1.4	-0.2	-0.7	1.0	0.9	1.2
Reaction time premature initiations	0.7	1.2	2.3	-0.5	-0.7	1.2	1.2	1.5
Std. dev. reaction times	0.3	0.5	0.7	-0.7	0.8	-0.6	-0.8	-0.6
Reaction time trials completed	0.5	0.9	1.8	-0.5	-0.5	1.1	1.0	1.3
Reaction time trials AUC	0.3	0.6	1.2	-0.5	-0.3	0.9	0.8	1.1
Run reversals in cocaine runway, females	3.4	3.4	3.8	-1.9	1.7	-2.0	-1.8	-1.9
Run reversals in cocaine runway, males	1.8	1.8	2.1	1.0	-1.4	1.4	1.4	1.4
Latency to leave start box in cocaine runway	0.0	0.0	0.0	0.2	0.0	0.0	0.2	-0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.6	0.5	-0.3	-0.3	-0.3
Latency to leave start box in cocaine runway, M	0.6	0.6	1.9	1.4	-0.7	0.4	0.6	0.1
Std. dev. time between licks in bursts	1.8	2.5	3.0	-1.7	1.6	-1.6	-1.5	-1.5
Total sessions with >9 infusions	4.4	5.4	5.9	-2.2	2.3	-2.4	-2.4	-2.3
Short access day 1 total inactive lever presses	1.7	2.2	3.8	-0.7	1.2	-1.9	-1.3	-1.9
Short access day 10 total inactive lever presses	0.0	0.1	0.2	0.4	-0.2	0.3	0.4	0.3
Short access day 1 total infusions	3.6	4.8	5.3	-2.2	2.2	-2.3	-2.1	-2.2
Short access day 10 total infusions	0.8	1.0	1.4	-0.9	0.9	-1.2	-0.9	-1.1
Short access total infusions	2.2	2.8	3.6	-1.3	1.6	-1.9	-1.6	-1.9
Short access day 1 locomotion	7.3	9.1	10.1	-2.6	3.0	-3.2	-3.2	-3.1
Short access day 10 total locomotion	1.1	2.0	5.0	-2.2	1.5	-1.1	-1.2	-0.7
Short access total locomotion	3.1	3.7	4.4	-2.1	1.9	-1.9	-2.0	-1.7
One hour access (0.3 mA shock)	0.7	0.8	1.4	-0.3	0.6	-1.1	-1.0	-1.2
Compulsive drug intake	1.0	1.2	2.4	1.5	-1.3	0.8	1.0	0.7
One hour access (shock baseline)	2.4	3.6	4.1	-1.6	1.9	-2.0	-2.0	-2.0
Social response proportion	2.7	3.0	5.2	-2.3	1.6	-1.6	-1.8	-1.2
Social responses	0.3	0.3	1.5	-1.2	0.2	-0.1	-0.3	0.3
Social time	0.1	0.2	0.6	-0.8	0.1	-0.3	-0.3	-0.1
Soleus weight	1.0	3.1	4.4	-1.0	1.7	-1.9	-1.8	-2.1
Bone: stiffness	5.2	8.4	12.2	-3.5	3.1	-2.7	-2.6	-2.4
Tibialis anterior weight	0.2	0.5	1.7	-1.3	0.9	0.2	-0.1	0.5
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.7	-0.4	-0.2	0.1	-0.4
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.6	-0.4	0.8	-0.4	-0.5	-0.4
Time to tail flick, test, before self-admin	2.5	2.6	3.3	-1.6	1.4	-1.7	-1.8	-1.6
Time to tail flick, test, after self-admin	0.7	0.7	2.1	1.4	-1.0	0.3	0.5	0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.3	0.2	0.3	0.1	0.5
Delta time to tail flick, test, before/after SA	1.9	1.9	3.3	1.8	-1.4	1.2	1.4	1.0
Tibia length	0.7	1.8	3.4	-1.8	1.5	-1.2	-1.1	-0.9
Ambulatory time before self-admin	1.2	1.8	2.6	-1.6	1.6	-1.1	-1.3	-1.0
Ambulatory time after self-admin	2.1	2.5	5.3	-2.3	1.8	-1.1	-1.3	-0.9
Bone: tissue strength	0.0	0.0	0.1	-0.2	0.3	-0.1	-0.1	-0.2
Total heroin consumption	0.1	0.1	0.1	-0.2	0.3	-0.1	-0.3	-0.2
Bone: trabecular number	1.0	1.7	3.8	-1.9	1.6	-0.7	-1.2	-0.4
Bone: trabecular spacing	0.2	0.3	0.7	0.8	-0.6	0.1	0.5	-0.0
Bone: trabecular thickness	0.6	0.7	2.3	-1.5	0.8	-0.4	-0.7	-0.1
Bone: trabecular tissue density	0.8	1.2	1.7	0.7	-1.1	1.1	1.3	1.1
Water consumed over 24 hours	0.1	0.2	0.4	-0.4	-0.1	0.5	0.5	0.6
Number of responses in last shaping day	0.1	0.1	0.4	-0.6	0.0	-0.4	-0.0	-0.2