Maip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Maip1	0.05	0.03	4.8e-05	0.02	0.03	0.03	0.03	6.9e-04	1.4e-04	2.9e-04	1.2e-04
2	PL	gene expression	Maip1	0.05	0.03	1.3e-04	0.05	0.04	0.04	0.04	5.0e-06	6.3e-05	6.4e-05	4.4e-05
3	BLA	gene expression	Maip1	0.13	0.06	4.0e-06	0.06	0.09	0.07	0.09	3.4e-04	1.8e-05	7.7e-05	2.8e-05
4	Liver	gene expression	Maip1	0.04	0.02	2.3e-04	0.01	0.03	0.02	0.02	1.5e-02	3.2e-04	1.0e-03	1.9e-03
5	Brain	gene expression	Maip1	0.07	0.03	5.5e-07	0.04	0.05	0.03	0.05	1.7e-04	1.5e-05	3.9e-04	3.8e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.4	0.7	1.7	1.3	-0.3	0.9	-0.5	0.9
Area under the delay curve	0.5	0.5	0.8	0.6	0.1	0.8	-0.8	0.9
BMI with tail	3.2	10.4	16.6	-3.8	4.1	-2.9	2.8	-2.2
BMI without tail	1.0	2.1	7.2	-1.6	2.7	-0.6	0.5	0.0
Body weight	0.2	1.0	1.5	1.0	-0.3	1.2	-1.0	1.2
Weight adjusted by age	0.0	0.0	0.1	0.3	-0.1	-0.1	0.2	0.0
Bone surface	2.8	5.0	8.6	2.9	-1.8	2.4	-1.8	2.0
Bone volume	1.4	2.4	4.8	2.2	-1.2	1.6	-1.1	1.4
Breakpoint value in progressive ratio session	0.2	0.3	0.7	0.2	-0.9	-0.3	0.5	-0.5
Number of licking bursts	0.2	0.2	0.3	-0.1	-0.5	-0.4	0.5	-0.5
Context. condit. distance diff. score	0.1	0.2	0.5	-0.4	0.7	-0.4	-0.3	0.0
Locomotion velocity, session 1	0.7	0.8	1.6	-1.3	1.2	-0.8	0.3	-0.5
Locomotion distance, session 1	1.1	1.5	2.8	-1.5	1.7	-1.2	0.7	-0.7
Locomotion velocity, session 2	0.3	0.3	1.1	-0.7	1.0	-0.2	-0.1	0.1
Locomotion distance, session 2	0.9	1.3	4.6	-1.3	2.2	-0.2	-0.0	0.4
Locomotion velocity, session 3	0.3	0.3	0.8	-0.5	0.9	-0.1	-0.5	0.5
Locomotion distance, session 3	0.2	0.2	0.4	0.3	-0.2	0.4	-0.6	0.5
Stereotopy head waving bouts, day 3	0.9	1.1	1.6	-0.9	0.3	-1.1	1.2	-1.2
Stereotopy head waving duration, day 3	1.3	1.6	2.2	-1.2	1.5	-1.2	1.3	-1.0
Locomotion velocity, session 7	0.7	0.8	1.4	-1.2	0.9	-0.9	0.7	-0.7
Locomotion distance, session 7	0.2	0.2	0.6	-0.8	0.7	-0.2	-0.0	0.0
Stereotopy head waving bouts, day 7	0.6	0.6	1.0	1.0	-0.5	0.8	-0.8	0.8
Stereotopy head waving duration, day 7	0.2	0.2	0.4	0.2	0.7	0.2	-0.4	0.5
Locomotion velocity, session 8	0.2	0.3	0.5	0.2	0.6	0.3	-0.7	0.7
Locomotion distance, session 8	0.2	0.3	0.8	-0.6	0.9	-0.2	-0.4	0.2
Degree of sensitization distance	0.5	0.5	0.8	-0.9	0.7	-0.7	0.7	-0.6
Degree of sensitization stereotypy	1.8	2.0	3.1	1.3	-0.1	1.5	-1.7	1.7
Conditioned locomotion	1.4	1.6	2.4	1.3	-0.2	1.5	-1.4	1.5
Cocaine response after cond. corrected	2.8	3.2	4.3	2.1	-1.0	1.9	-1.9	1.8
Cocaine response after cond. not corrected	2.4	2.6	4.5	2.1	-1.3	1.6	-1.4	1.5
Cocaine response before conditioning	1.0	1.2	2.3	-0.6	-0.2	-1.3	1.5	-1.3
Saline control response	0.1	0.1	0.1	-0.2	0.2	-0.3	0.3	-0.2
Bone: connectivity density	0.4	0.7	1.3	1.1	0.0	0.9	-0.5	1.0
Bone: cortical apparent density	4.3	5.6	7.8	-2.8	0.8	-2.5	2.5	-2.7
Bone: cortical area	0.9	1.4	4.0	1.4	-2.0	1.0	-0.4	0.2
Bone: cortical porosity	3.3	3.6	5.9	2.4	-2.3	1.7	-1.5	1.2
Bone: cortical porosity	3.8	4.1	7.0	2.6	-2.4	1.9	-1.6	1.4
Bone: cortical thickness	0.5	0.9	1.7	-0.7	-0.6	-0.7	1.1	-1.3
Bone: cortical thickness	2.1	2.5	3.4	-1.7	0.2	-1.7	1.8	-1.9
Bone: cortical tissue density	4.3	5.6	8.1	-2.9	1.0	-2.5	2.4	-2.6
Condit. Reinf. active minus inactive responses	0.6	0.7	2.5	0.6	-1.6	-0.1	0.4	-0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.3	-0.7	-0.2	0.5	-0.5
Condit. Reinf. active responses	1.1	1.3	3.8	1.4	-2.0	0.7	-0.5	0.3
Condit. Reinf. inactive responses	0.7	0.8	1.1	1.0	-1.0	0.9	-0.9	0.7
Incentive salience index mean	1.1	1.3	4.7	1.3	-2.2	0.3	0.1	-0.3
Condit. Reinf. lever presses	1.0	1.3	3.7	1.4	-1.9	0.7	-0.7	0.3
Condit. Reinf. active minus inactive responses	1.1	1.4	3.5	1.5	-1.9	0.7	-0.5	0.4
Condit. Reinf. active-inactive response ratio	1.0	1.0	3.8	0.7	-1.9	-0.3	0.5	-0.7
Condit. Reinf. active responses	0.8	1.1	2.9	1.3	-1.7	0.6	-0.4	0.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.3	-0.1	0.4	-0.4	0.4
Condit. Reinf. lever presses	1.3	1.8	3.0	-0.9	-0.5	-1.5	1.6	-1.7
Condit. Reinf. lever reinforcers received	0.7	1.0	2.9	1.2	-1.7	0.5	-0.4	0.2
Conditioned reinforcement - actives	0.2	0.2	0.3	0.5	-0.4	0.5	-0.4	0.3
Conditioned reinforcement - inactives	0.8	0.9	2.9	1.0	-1.7	0.6	-0.4	0.1
Conditioned locomotion	0.4	0.4	1.3	-0.8	1.1	-0.3	0.3	-0.0
Patch foraging indifference point 0 sec	0.5	0.8	1.5	-0.7	-0.0	-0.9	1.2	-1.1
Patch foraging indifference point AUC	0.3	0.4	1.6	0.6	-1.3	0.2	0.1	-0.2
Delay disc. indifference point, 0s delay	2.0	2.1	5.1	-1.7	2.3	-1.1	1.0	-0.7
Delay disc. indifference point, 16s delay	0.8	0.8	1.2	1.1	-0.9	0.9	-0.9	0.8
Delay disc. indifference point, 2s delay	1.2	1.3	4.2	-1.1	2.0	-0.8	0.7	-0.3
Delay disc. indifference point, 24s delay	0.1	0.0	0.1	0.3	-0.3	0.2	-0.1	0.1
Delay disc. indifference point, 4s delay	0.5	0.5	2.1	-0.7	1.4	-0.3	0.0	0.1
Delay disc. indifference point, 8s delay	2.5	2.6	3.4	1.8	-1.0	1.8	-1.6	1.6
Indifference point function ln k	0.1	0.2	0.6	-0.3	0.8	-0.0	-0.3	0.3
Indifference point function log k	0.1	0.2	0.6	-0.3	0.8	-0.0	-0.3	0.3
Patch foraging total patch changes 0 sec	0.9	1.5	2.6	-0.9	0.1	-1.3	1.6	-1.5
Patch foraging total patch changes 12 sec	0.7	0.9	1.3	-0.4	-1.1	-0.7	1.1	-1.2
Patch foraging total patch changes 18 sec	2.7	3.5	5.4	-1.7	0.2	-1.9	2.3	-2.3
Patch foraging total patch changes 24 sec	0.4	0.5	1.5	0.1	-1.2	-0.2	0.5	-0.6
Patch foraging total patch changes 6 sec	0.2	0.3	0.9	-0.3	0.1	-0.6	0.9	-0.6
Patch foraging time to switch 0 sec	0.2	0.3	0.5	-0.6	0.7	-0.5	0.5	-0.2
Patch foraging water rate 0 sec	0.3	0.5	0.8	0.9	-0.6	0.8	-0.7	0.5
Patch foraging water rate 12 sec	0.2	0.3	1.2	-0.0	1.1	0.0	-0.2	0.4
Patch foraging water rate 18 sec	0.1	0.1	0.1	0.3	-0.4	-0.2	0.3	-0.3
Patch foraging water rate 24 sec	0.3	0.4	0.7	0.1	0.8	0.5	-0.6	0.8
Patch foraging water rate 6 sec	0.1	0.1	0.5	0.0	0.7	0.2	-0.1	0.3
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	2.0	1.4	-0.4	1.3	-1.3	1.4
Distance traveled before self-admin	1.1	1.1	2.0	1.2	-1.4	0.9	-0.8	0.8
Distance traveled after self-admin	0.2	0.2	0.4	0.4	-0.5	0.6	-0.4	0.5
Extensor digitorum longus weight	1.1	4.4	7.5	-2.7	2.4	-1.8	1.9	-1.5
Bone: elastic displacement	1.0	1.2	1.8	-1.2	0.8	-1.3	1.0	-1.0
Bone: elastic work	0.0	0.0	0.1	-0.0	-0.2	-0.2	0.2	-0.2
Bone: endosteal estimation	2.0	4.4	8.2	2.9	-2.4	2.0	-1.4	1.5
Bone: endosteal perimeter	2.3	4.7	8.4	2.9	-1.9	2.2	-1.7	1.8
Epididymis fat weight	1.9	4.4	6.4	2.0	-1.1	2.5	-2.3	2.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.2	0.1	-0.4	0.1	-0.2	-0.0
Delta time in open arm before/after self-admin	2.9	2.8	4.7	2.2	-2.1	1.4	-1.3	1.1
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	0.4	-0.3	-0.1	0.1	0.0
Delay discount exponential model param	0.5	0.5	0.8	-0.7	-0.0	-0.8	0.8	-0.9
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.5	-0.1	0.2	0.0	0.2
Active lever presses in extinction session 6	0.5	0.5	0.7	0.6	-0.6	0.7	-0.8	0.7
Bone: final force	1.0	1.6	3.2	1.6	-1.8	1.2	-0.6	0.6
Bone: final moment	0.4	0.6	1.8	1.0	-1.4	0.5	-0.0	0.0
Food consumed during 24 hour testing period	2.0	2.4	3.1	-1.8	1.4	-1.6	1.6	-1.4
Glucose	0.8	1.2	2.1	-1.4	1.4	-0.9	1.0	-0.7
Heart weight	0.0	0.1	0.2	0.5	0.0	0.2	0.1	0.2
Delay discount hyperbolic model param	0.3	0.4	0.6	-0.5	-0.4	-0.6	0.7	-0.8
Intermittent access intake day 1-15 change	1.7	1.7	2.4	-1.3	0.7	-1.5	1.6	-1.3
Intermittent access intake escalation	1.6	1.5	2.3	-1.1	0.3	-1.5	1.5	-1.3
Intermittent access intake escalation 2	0.4	0.3	0.7	-0.4	-0.1	-0.7	0.8	-0.6
Intermitt. access day 1 inactive lever presses	1.6	1.8	2.4	-1.5	0.3	-1.5	1.4	-1.5
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.3	-0.3	-0.3	-0.4	0.6	-0.5
Intermitt. access escalation Index	0.2	0.2	0.5	0.4	-0.0	0.7	-0.4	0.4
Intermittent access day 1 total infusions	0.1	0.1	0.4	0.2	-0.6	0.1	-0.3	-0.0
Intermittent access day 15 total infusions	0.7	0.8	1.3	-0.5	-0.5	-1.0	1.0	-1.1
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.9	-0.9	-0.0	-1.3	1.3	-1.4
Intermittent access total infusions	0.3	0.4	0.7	-0.4	-0.4	-0.7	0.6	-0.8
Intermittent access day 1 locomotion	0.4	0.4	0.8	-0.4	-0.6	-0.6	0.5	-0.9
Intermittent access day 15 total locomotion	0.6	0.6	1.2	-0.4	-0.5	-0.8	1.0	-1.1
Intermittent access total locomotion	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.3	-0.5
Intermittent access standard deviation	2.0	2.1	3.3	-1.3	-0.1	-1.8	1.6	-1.8
Left kidney weight	0.0	0.1	0.2	0.3	-0.3	0.2	0.4	-0.1
Right kidney weight	0.1	0.3	0.5	0.7	-0.1	0.7	-0.3	0.6
Cocaine induced anxiety	0.1	0.1	0.5	-0.4	0.7	0.1	0.1	0.2
Post-drug Anxiety	0.1	0.1	0.6	-0.2	0.8	-0.0	-0.2	0.3
Baseline Anxiety	0.5	0.5	0.9	0.9	-1.0	0.4	-0.7	0.3
Tail length	6.1	18.5	25.6	5.1	-4.5	4.3	-4.0	3.6
Length with tail	6.7	24.5	34.0	5.8	-5.2	4.9	-4.6	4.1
Length without tail	1.6	3.5	6.7	2.3	-2.6	1.6	-1.4	1.1
Times rat made contact with spout	1.5	1.7	3.0	-1.7	1.6	-1.2	0.8	-0.8
Lifetime Intake	0.2	0.2	0.4	-0.5	-0.0	-0.6	0.5	-0.6
Liver weight, left	1.5	2.3	3.8	1.3	-0.2	1.7	-1.7	1.9
Liver weight, right	1.2	2.0	3.5	1.9	-1.3	1.3	-1.2	1.3
Locomotor activity	0.3	0.5	0.9	-0.6	0.8	-0.6	0.9	-0.6
Locomotor testing distance	2.1	3.5	5.3	-1.8	1.5	-1.9	2.3	-1.8
Locomotor testing rearing	0.1	0.1	0.2	-0.4	0.4	-0.3	0.3	-0.2
Locomotion in novel chamber	6.1	7.6	10.0	-2.7	1.4	-3.2	3.1	-2.9
Locomotion in novel chamber post-restriction	1.1	1.4	2.5	-0.5	-0.7	-1.2	1.5	-1.6
Fecal boli incidents, locomotor time 1	0.7	0.7	1.4	1.2	-0.8	0.7	-0.7	0.7
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.0	0.3	0.1	0.2	-0.1
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.7	0.8	-0.8	0.6	-0.1	0.2
Bouts of movement, locomotor time 1	0.9	1.0	3.4	0.6	-1.8	-0.3	0.4	-0.9
Total resting periods, locomotor time 1	1.1	1.2	2.8	0.0	-1.7	-0.8	0.8	-1.4
Rest time, locomotor task time 1	0.6	0.7	1.5	-0.4	-1.2	-0.6	0.5	-1.1
Distance moved, locomotor task time 1	1.4	1.5	2.6	1.2	-0.0	1.5	-1.1	1.6
Vertical activity count, locomotor time 1	0.5	0.5	1.0	0.3	0.6	0.8	-0.7	1.0
Time >=10cm from walls, locomotor time 2	0.5	0.5	2.2	-0.4	1.5	0.3	-0.2	0.6
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0
Total resting periods, locomotor time 2	0.1	0.1	0.1	-0.0	-0.3	-0.2	0.3	-0.4
Rest time, locomotor task time 2	0.5	0.6	1.8	-0.1	-1.3	-0.4	0.3	-0.9
Distance moved, locomotor task time 2	0.1	0.2	0.2	0.4	0.4	0.4	0.0	0.5
Vertical activity count, locomotor time 2	1.4	1.5	4.5	-1.2	2.1	-0.8	0.9	-0.3
Light reinforcement 1	3.3	6.1	10.2	-3.0	3.2	-2.1	2.1	-1.6
Light reinforcement 2	0.2	0.2	0.4	0.4	0.2	0.6	-0.4	0.6
Bone: marrow area	2.0	4.3	8.1	2.8	-2.5	1.9	-1.3	1.3
Bone: maximum diameter	2.3	4.2	7.7	2.6	-2.8	1.9	-1.4	1.1
Bone: maximum force	0.6	1.1	2.2	1.5	-1.3	1.0	-0.4	0.5
Bone: maximum moment	0.1	0.3	0.6	0.7	-0.8	0.3	0.3	-0.0
Mean time between licks in bursts	0.3	0.4	0.5	-0.2	0.7	0.6	-0.6	0.7
Mean num. licks in bursts	0.7	0.8	2.4	-1.1	1.6	-0.4	0.3	-0.2
Cd content in liver	0.1	0.1	0.1	0.3	-0.1	0.2	-0.2	0.3
Co content in liver	0.5	0.6	1.2	-0.8	-0.1	-1.1	0.5	-0.9
Cu content in liver	0.3	0.4	0.9	0.7	-1.0	0.6	-0.3	0.2
Fe content in liver	0.1	0.1	0.2	-0.0	-0.3	-0.4	0.5	-0.4
K content in liver	0.8	0.8	1.4	0.9	-1.2	0.8	-0.8	0.6
Mg content in liver	0.1	0.1	0.1	0.3	-0.1	0.3	-0.1	0.3
Mn content in liver	2.0	2.3	3.1	-1.6	0.4	-1.7	1.6	-1.8
Na content in liver	1.0	1.1	2.8	1.2	-1.7	0.8	-0.4	0.3
Rb content in liver	2.4	3.0	4.4	1.7	-0.3	1.9	-2.0	2.1
Se content in liver	0.3	0.4	0.7	-0.5	0.2	-0.6	0.8	-0.7
Sr content in liver	0.1	0.1	0.2	-0.4	-0.1	-0.2	0.3	-0.4
Zn content in liver	0.1	0.1	0.4	-0.2	0.7	0.1	-0.1	0.2
Bone: minimum diameter	1.0	1.8	4.9	1.7	-2.2	1.1	-0.3	0.2
Time in familiar zone, hab. session 1	0.1	0.1	0.1	0.3	0.4	-0.1	-0.1	0.2
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.0	-0.6	0.3	-0.2	0.0
Total zone transitions, hab. session 1	0.1	0.2	0.5	0.4	-0.0	0.3	-0.7	0.6
Total locomotion distance, hab. session 1	0.3	0.4	1.5	0.7	-1.2	0.1	-0.1	-0.1
Locomotion velocity, hab. session 1	0.3	0.4	1.5	0.7	-1.2	0.2	-0.1	-0.1
Time in familiar zone, hab. session 2	1.5	1.6	2.5	-1.0	-0.4	-1.4	1.5	-1.6
Time in novel zone, hab. session 2	0.4	0.4	0.8	0.0	0.9	0.6	-0.6	0.8
Total zone transitions, hab. session 2	0.9	1.2	3.3	-1.3	1.8	-0.7	0.4	-0.2
Total locomotion distance, hab. session 2	0.7	0.9	2.6	-1.1	1.6	-0.6	0.5	-0.3
Locomotion velocity, hab. session 2	0.5	0.7	2.2	-1.0	1.5	-0.5	0.4	-0.2
Novel to familiar place preference ratio	0.3	0.3	1.2	-0.4	1.1	0.0	-0.1	0.4
Novelty place preference	0.2	0.2	1.0	-0.4	1.0	-0.1	0.0	0.2
Time in novel zone, NPP test	0.3	0.3	1.3	-0.6	1.1	-0.2	0.1	0.1
Total zone transitions, NPP test	0.1	0.1	0.2	-0.4	0.4	-0.4	0.1	-0.2
Total locomotion distance, NPP test	1.1	1.5	2.0	-1.1	0.6	-1.4	1.4	-1.3
Locomotion velocity, NPP test	1.2	1.7	2.3	-1.3	0.5	-1.5	1.5	-1.5
Intraocular pressure	4.3	6.0	7.5	-2.7	1.7	-2.6	2.6	-2.5
Delta distance traveled before/after self-admin	0.6	0.7	1.2	-1.0	1.1	-0.6	0.8	-0.6
Delta ambulatory time before/after self-admin	0.3	0.3	0.6	-0.8	0.7	-0.3	0.5	-0.4
Parametrial fat weight	0.0	0.1	0.1	-0.1	0.1	0.3	-0.3	0.3
Pavlov. Cond. lever latency	0.6	0.7	1.4	-1.2	1.0	-0.6	0.6	-0.5
Pavlov. Cond. magazine entry latency	0.5	0.7	2.2	0.6	-1.5	-0.3	0.5	-0.7
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	0.5	-0.8	-0.2	0.3	-0.4
Pavlov. Cond. index score	0.6	0.7	2.6	0.9	-1.6	0.0	0.0	-0.3
Pavlov. Cond. latency score	0.6	0.7	2.4	1.1	-1.5	0.2	-0.1	-0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.7	0.5	-0.8	-0.1	0.1	-0.2
Pavlov. Cond. magazine entry number	0.4	0.5	1.4	-0.8	1.2	-0.1	-0.2	0.3
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.8	1.1	-0.2	1.2	-1.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	2.4	0.7	-1.5	-0.3	0.3	-0.6
Pavlov. Cond. response bias	0.6	0.7	2.6	0.9	-1.6	0.0	0.2	-0.4
Pavlov. Cond. lever latency	1.6	2.2	3.8	1.0	0.9	1.7	-1.6	2.0
Pavlov. Cond. magazine entry latency	0.6	0.7	1.3	-0.5	-0.6	-0.9	0.8	-1.1
Pavlov. Cond. change in total contacts	1.2	1.6	6.5	1.0	-2.5	0.0	0.1	-0.7
Pavlov. Cond. index score	0.9	1.2	2.1	-0.2	-1.4	-1.0	0.9	-1.4
Pavlov. Cond. latency score	0.9	1.2	2.0	-0.3	-1.4	-1.0	1.0	-1.4
Pavlov. Cond. lever contacts	1.4	1.9	3.4	-0.7	-1.3	-1.4	1.4	-1.8
Pavlov. Cond. magazine entry number	0.3	0.4	1.1	-0.1	1.1	0.4	-0.5	0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.3	1.4	-0.4	1.2	-0.2	0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	2.5	-0.1	-1.6	-0.8	0.8	-1.3
Pavlov. Cond. response bias	0.9	1.2	2.0	-0.4	-1.2	-1.1	1.0	-1.4
Time in closed arm before self-admin	1.5	1.7	3.0	1.6	-1.7	1.1	-1.0	0.9
Time in closed arm after self-admin	0.8	0.8	1.0	1.0	-1.0	0.8	-0.9	0.8
Time in open arm before self-admin	3.1	3.3	5.2	-2.3	2.2	-1.5	1.6	-1.3
Time in open arm after self-admin	0.5	0.6	1.3	1.0	-1.1	0.6	-0.5	0.3
Bone: periosteal estimation	2.1	4.3	8.3	2.7	-2.9	1.9	-1.1	1.0
Bone: periosteal perimeter	1.4	2.3	4.3	2.1	-2.0	1.4	-0.9	0.8
Bone: post-yield work	0.3	0.5	1.1	-0.4	0.5	-0.6	1.0	-0.7
Progressive ratio test 1 active lever presses	0.7	0.7	1.4	-0.6	-0.4	-0.9	1.0	-1.2
Progressive ratio test 1 breakpoint	1.0	1.1	2.0	-0.7	-0.4	-1.1	1.2	-1.4
Progressive ratio test 1 inactive lever presses	3.8	4.1	5.8	-2.4	1.4	-2.1	2.0	-2.1
Progressive ratio test 2 active lever presses	0.3	0.3	0.6	-0.0	-0.7	-0.4	0.6	-0.8
Progressive ratio test 2 breakpoint	0.7	0.8	1.6	-0.5	-0.4	-0.9	1.1	-1.3
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.1	-0.8	0.0	-0.9	0.9	-1.1
Incentive Sensitization - Responses	0.5	0.5	1.0	0.8	-1.0	0.7	-0.6	0.4
Incentive Sensitization - Breakpoint	0.5	0.5	0.9	0.8	-0.9	0.7	-0.5	0.4
Sum of active levers in priming session hrs 5-6	1.8	1.7	2.4	1.3	-0.8	1.6	-1.4	1.4
Progressive ratio	0.2	0.3	0.6	-0.8	0.3	-0.5	0.3	-0.5
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.5	-0.2	0.2	-0.2	0.3
Seeking ratio, punishment vs. effort	0.8	1.0	1.7	1.3	-0.3	1.0	-0.8	1.2
Retroperitoneal fat weight	0.3	0.9	1.5	0.4	0.8	0.9	-1.2	1.2
Reaction time number correct	0.9	1.3	1.7	-1.2	1.3	-1.2	1.2	-0.9
Reaction time mean minus median	0.0	0.0	0.0	0.1	0.1	0.1	-0.2	0.1
Reaction time mean minus median AUC	0.2	0.3	0.5	-0.3	-0.1	-0.7	0.6	-0.7
Reaction time num false alarms	0.8	1.0	2.3	-1.3	1.5	-0.7	0.7	-0.5
Reaction time num false alarms AUC	0.8	1.2	2.7	-1.3	1.6	-0.8	0.7	-0.5
Reaction time trials correct on left	0.9	1.3	1.7	-1.2	1.3	-1.2	1.2	-0.9
Reaction time trials on left	0.9	1.2	1.6	-1.2	1.3	-1.1	1.1	-0.8
Reaction time mean	2.6	3.6	4.9	2.1	-2.2	1.8	-1.9	1.4
Reaction time mean AUC	2.0	2.7	3.9	1.8	-2.0	1.6	-1.6	1.1
Median of all reaction times	4.1	5.6	8.3	2.6	-2.9	2.2	-2.3	1.6
Reaction time omissions	0.5	0.7	0.9	0.9	-0.5	0.9	-1.0	0.9
Reaction time false alarm rate	0.1	0.1	0.5	-0.4	0.7	0.0	-0.0	0.1
Reaction time premature initiation rate	1.3	1.8	3.2	-0.7	-0.5	-1.4	1.8	-1.7
Reaction time premature initiations	2.2	3.1	5.2	-1.4	0.4	-2.0	2.3	-2.1
Std. dev. reaction times	0.8	1.1	1.5	1.2	-1.0	1.0	-1.0	0.9
Reaction time trials completed	0.9	1.2	1.6	-1.2	1.3	-1.1	1.1	-0.8
Reaction time trials AUC	0.7	1.0	1.3	-1.1	1.1	-1.0	1.0	-0.8
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.2	0.5	-0.1	0.1	-0.0
Run reversals in cocaine runway, males	0.4	0.4	1.1	0.1	-1.0	-0.5	0.4	-0.7
Latency to leave start box in cocaine runway	3.9	4.2	6.3	-2.5	2.3	-2.0	1.8	-1.6
Latency to leave start box in cocaine runway, F	2.0	2.1	3.4	-1.8	1.7	-1.3	1.2	-1.1
Latency to leave start box in cocaine runway, M	2.6	2.5	3.1	-1.6	1.0	-1.8	1.7	-1.6
Std. dev. time between licks in bursts	1.2	1.5	2.2	-1.5	1.0	-1.2	1.2	-1.1
Total sessions with >9 infusions	1.4	1.6	2.2	-1.5	1.1	-1.3	1.2	-1.2
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.3	0.1	-0.1	0.2	-0.1
Short access day 10 total inactive lever presses	0.2	0.2	0.4	-0.6	-0.0	-0.6	0.4	-0.5
Short access day 1 total infusions	0.8	0.9	1.2	-1.1	0.6	-1.0	1.0	-1.0
Short access day 10 total infusions	0.1	0.1	0.1	-0.1	-0.3	-0.3	0.2	-0.3
Short access total infusions	0.6	0.7	1.0	-1.0	0.7	-0.9	0.7	-0.8
Short access day 1 locomotion	1.2	1.3	2.3	-0.8	-0.6	-1.1	1.4	-1.5
Short access day 10 total locomotion	0.3	0.4	0.7	-0.5	-0.3	-0.7	0.7	-0.8
Short access total locomotion	0.4	0.4	0.6	-0.8	0.4	-0.7	0.7	-0.7
One hour access (0.3 mA shock)	0.8	0.9	2.0	-0.0	-1.4	-0.8	0.7	-1.2
Compulsive drug intake	0.2	0.2	0.6	0.3	-0.7	-0.1	0.0	-0.4
One hour access (shock baseline)	0.1	0.2	0.5	0.0	-0.7	-0.3	0.2	-0.4
Social response proportion	1.2	1.3	2.3	1.5	-0.6	1.3	-1.0	1.2
Social responses	1.2	1.5	2.7	1.6	-1.0	1.4	-0.9	1.1
Social time	0.4	0.5	1.3	1.1	-0.8	0.7	-0.3	0.4
Soleus weight	0.1	0.2	0.8	0.1	0.9	0.3	-0.1	0.6
Bone: stiffness	2.8	4.4	7.1	2.7	-1.9	2.3	-1.7	1.8
Tibialis anterior weight	0.1	0.2	0.5	-0.7	0.2	-0.5	0.4	-0.4
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	-0.0	-0.2	-0.0	0.1	-0.1
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.1	0.0	-0.0	0.1	-0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.1	-0.1	0.3	-0.5	0.3
Time to tail flick, test, after self-admin	2.1	2.2	3.1	-1.8	1.5	-1.6	1.2	-1.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.1	-0.7	1.0	-0.5	0.4	-0.2
Delta time to tail flick, test, before/after SA	2.9	2.6	3.6	-1.6	1.1	-1.9	1.8	-1.7
Tibia length	3.5	9.9	15.8	4.0	-3.3	3.2	-2.6	2.4
Ambulatory time before self-admin	0.6	0.6	1.0	0.8	-0.4	0.9	-0.8	1.0
Ambulatory time after self-admin	0.0	0.0	0.1	-0.1	0.2	0.3	0.2	0.1
Bone: tissue strength	0.1	0.1	0.2	0.2	0.4	0.3	-0.1	0.3
Total heroin consumption	0.1	0.1	0.3	0.2	-0.5	-0.1	0.5	-0.4
Bone: trabecular number	0.9	1.4	2.2	1.5	-0.2	1.2	-1.1	1.4
Bone: trabecular spacing	0.0	0.0	0.1	-0.2	-0.0	0.0	-0.3	-0.0
Bone: trabecular thickness	0.1	0.1	0.2	0.0	0.4	-0.2	0.4	-0.1
Bone: trabecular tissue density	0.6	0.8	2.4	-0.1	-1.5	-0.5	0.5	-1.0
Water consumed over 24 hours	6.1	7.3	9.9	-3.2	2.0	-2.9	2.8	-2.6
Number of responses in last shaping day	0.5	0.5	1.0	-0.3	-0.1	-0.6	1.0	-1.0