Hub : Genes

Lysmd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Lysmd2 0.11 0.07 2.3e-05 0 0.03 0.03 0.02 2.4e-01 3.7e-04 1.7e-04 5.6e-03
2 LHb gene expression Lysmd2 0.26 0.12 2.9e-05 0.14 0.19 0.11 0.14 3.1e-04 2.9e-05 1.6e-03 3.8e-04
3 pVTA gene expression Lysmd2 0.08 0.04 6.1e-08 0.1 0.09 0.09 0.09 1.1e-08 6.4e-08 1.1e-07 7.2e-08
4 Brain alternative TSS XM_063265183.1 0.04 0.03 1.4e-03 0.04 0.03 0.03 0.04 3.1e-04 6.5e-04 6.1e-04 1.6e-04
5 PL intron excision ratio chr8_85260164_85272753 0.03 0.02 6.5e-03 0.02 0.02 0.01 0.01 1.0e-03 5.4e-03 8.3e-03 1.1e-02
6 PL intron excision ratio chr8_85273084_85274322 0.03 0.02 7.6e-04 0.04 0.03 0.04 0.04 3.4e-05 3.3e-04 7.1e-05 4.8e-05
7 NAcc alternative polyA XM_063265182.1 0.03 0.02 6.1e-03 0.01 0.01 0.01 0.01 9.7e-03 1.3e-02 2.4e-02 1.5e-02
8 Adipose gene expression Lysmd2 0.08 0.04 2.6e-06 0.03 0.02 0.02 0.02 8.1e-04 9.2e-04 1.3e-03 1.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.20.4-0.70.1-0.10.6-0.20.20.6-0.5
Area under the delay curve0.91.41.91.3-1.31.2-1.1-1.21.2-1.40.0
BMI with tail2.910.020.23.7-3.32.6-4.5-2.52.5-3.90.9
BMI without tail0.84.210.31.4-2.01.1-3.2-1.91.9-2.71.2
Body weight2.812.132.13.4-3.21.9-5.7-2.42.4-4.81.9
Weight adjusted by age0.72.03.31.4-1.81.7-0.9-1.41.4-1.5-0.5
Bone surface1.12.14.30.7-1.61.70.1-2.12.10.1-1.6
Bone volume0.50.91.90.4-1.21.1-0.2-1.41.4-0.2-0.9
Breakpoint value in progressive ratio session0.71.22.30.7-1.31.3-0.5-1.51.5-0.1-1.1
Number of licking bursts0.72.23.71.2-1.91.8-0.6-1.91.9-0.6-1.0
Context. condit. distance diff. score0.40.51.31.2-0.81.10.1-0.50.50.1-0.7
Locomotion velocity, session 10.50.61.10.7-0.70.4-1.0-0.70.7-1.00.5
Locomotion distance, session 10.60.83.9-2.00.5-0.80.7-0.30.30.6-0.0
Locomotion velocity, session 20.60.81.90.4-0.90.6-0.6-1.41.4-0.80.0
Locomotion distance, session 20.60.82.4-1.6-0.0-0.8-0.5-1.01.0-0.61.0
Locomotion velocity, session 31.71.95.2-1.40.10.12.3-0.90.91.9-1.7
Locomotion distance, session 32.62.96.8-2.61.6-1.52.40.4-0.42.3-0.7
Stereotopy head waving bouts, day 31.01.23.40.40.10.61.60.7-0.71.4-1.8
Stereotopy head waving duration, day 30.70.92.41.3-0.31.00.80.6-0.60.6-1.5
Locomotion velocity, session 70.30.31.2-0.60.3-0.21.10.1-0.10.6-0.2
Locomotion distance, session 70.20.20.6-0.4-0.20.10.4-0.80.80.2-0.3
Stereotopy head waving bouts, day 71.21.43.8-0.2-0.00.61.9-0.50.51.7-2.0
Stereotopy head waving duration, day 71.01.23.3-0.2-0.10.61.7-0.60.61.5-1.8
Locomotion velocity, session 80.50.61.6-0.2-0.50.40.6-1.31.30.5-0.7
Locomotion distance, session 80.50.72.0-0.6-0.70.40.4-1.41.40.3-0.4
Degree of sensitization distance1.81.93.61.9-1.51.3-1.8-0.80.8-1.70.4
Degree of sensitization stereotypy0.91.02.5-0.3-0.10.51.5-0.70.71.5-1.6
Conditioned locomotion0.60.71.7-0.40.4-0.9-0.70.9-0.9-0.91.3
Cocaine response after cond. corrected1.21.85.22.3-1.51.7-1.1-1.01.0-0.8-0.6
Cocaine response after cond. not corrected2.02.98.62.9-1.92.0-1.8-1.01.0-1.4-0.3
Cocaine response before conditioning1.41.73.71.6-1.51.1-1.9-0.80.8-1.60.4
Saline control response1.01.43.4-0.10.60.21.80.7-0.71.8-1.8
Bone: connectivity density1.11.85.6-2.41.1-1.11.80.3-0.31.8-0.6
Bone: cortical apparent density1.92.95.7-1.12.2-1.90.92.4-2.40.91.1
Bone: cortical area0.40.61.70.9-0.10.80.60.5-0.50.7-1.3
Bone: cortical porosity0.30.30.5-0.60.4-0.40.60.7-0.70.6-0.3
Bone: cortical porosity0.40.50.9-0.80.4-0.40.90.7-0.70.9-0.6
Bone: cortical thickness1.93.17.3-0.72.1-1.41.42.7-2.71.20.0
Bone: cortical thickness0.60.72.10.70.6-0.3-0.21.5-1.5-0.20.2
Bone: cortical tissue density1.72.75.1-1.12.1-1.90.82.3-2.30.81.1
Condit. Reinf. active minus inactive responses0.91.12.1-0.3-0.4-0.3-1.3-1.11.1-1.41.5
Condit. Reinf. active-inactive response ratio0.40.51.81.4-0.30.4-0.9-0.10.1-0.80.4
Condit. Reinf. active responses1.11.43.3-0.8-0.8-0.1-1.0-1.81.8-1.11.0
Condit. Reinf. inactive responses0.70.92.5-1.5-0.6-0.1-0.1-1.61.6-0.20.2
Incentive salience index mean1.21.53.3-0.0-1.40.7-1.2-1.81.8-1.20.5
Condit. Reinf. lever presses1.31.94.0-0.1-2.01.5-0.5-2.02.0-0.5-0.9
Condit. Reinf. active minus inactive responses0.50.82.31.5-0.81.1-0.1-0.90.90.2-0.9
Condit. Reinf. active-inactive response ratio0.40.71.80.9-0.00.71.00.1-0.11.1-1.3
Condit. Reinf. active responses1.31.93.21.8-1.51.2-1.6-1.41.4-1.30.2
Condit. Reinf. inactive responses1.72.55.80.9-1.50.7-2.4-1.41.4-2.31.3
Condit. Reinf. lever presses1.42.05.42.3-1.52.0-0.4-1.01.0-0.2-1.5
Condit. Reinf. lever reinforcers received1.21.63.21.8-1.31.1-1.6-1.21.2-1.30.3
Conditioned reinforcement - actives0.10.61.10.7-1.00.9-0.7-0.60.6-0.3-1.0
Conditioned reinforcement - inactives0.00.10.40.1-0.30.1-0.5-0.30.3-0.60.1
Conditioned locomotion0.20.40.70.00.3-0.5-0.70.7-0.7-0.50.9
Patch foraging indifference point 0 sec0.10.30.70.6-0.40.70.3-0.50.50.4-0.9
Patch foraging indifference point AUC0.51.13.4-1.40.4-1.3-1.20.1-0.1-0.81.9
Delay disc. indifference point, 0s delay0.40.41.0-1.00.1-0.5-0.4-0.60.6-0.51.0
Delay disc. indifference point, 16s delay0.10.20.50.7-0.00.1-0.50.3-0.3-0.60.3
Delay disc. indifference point, 2s delay0.60.71.71.0-0.80.6-0.6-0.80.8-1.30.6
Delay disc. indifference point, 24s delay0.10.10.30.3-0.30.3-0.5-0.10.1-0.60.1
Delay disc. indifference point, 4s delay0.70.71.30.7-1.00.9-0.6-1.11.1-0.8-0.2
Delay disc. indifference point, 8s delay2.23.65.11.9-2.31.8-2.0-2.02.0-2.1-0.0
Indifference point function ln k0.41.33.81.6-0.71.51.0-0.30.30.8-2.0
Indifference point function log k0.41.33.81.6-0.71.51.0-0.30.30.8-2.0
Patch foraging total patch changes 0 sec0.10.20.50.7-0.30.50.1-0.20.20.2-0.5
Patch foraging total patch changes 12 sec0.50.71.8-1.30.7-1.0-0.10.6-0.60.21.0
Patch foraging total patch changes 18 sec0.10.10.3-0.20.4-0.3-0.10.6-0.60.20.3
Patch foraging total patch changes 24 sec0.10.51.4-0.80.6-0.9-0.3-0.10.1-0.41.2
Patch foraging total patch changes 6 sec0.30.52.1-1.40.7-0.90.4-0.20.20.50.5
Patch foraging time to switch 0 sec0.20.92.2-1.20.7-0.41.50.6-0.61.3-0.7
Patch foraging water rate 0 sec0.51.85.62.4-1.21.2-1.6-0.80.8-1.50.3
Patch foraging water rate 12 sec0.41.54.22.0-1.21.3-0.9-1.21.2-0.8-0.7
Patch foraging water rate 18 sec0.30.61.40.60.7-0.7-0.40.8-0.8-0.71.2
Patch foraging water rate 24 sec0.10.10.20.10.5-0.30.50.5-0.50.2-0.0
Patch foraging water rate 6 sec1.01.52.91.7-1.31.3-0.7-1.51.5-0.7-0.6
Seeking ratio, delayed vs. immediate footshock3.24.69.31.6-2.62.3-1.3-3.13.1-1.0-1.1
Distance traveled before self-admin0.71.62.90.8-1.41.50.5-1.71.7-0.0-1.5
Distance traveled after self-admin1.72.94.61.9-2.12.1-0.7-1.91.9-0.6-1.6
Extensor digitorum longus weight1.03.97.81.0-2.11.4-2.1-2.82.8-2.10.3
Bone: elastic displacement0.70.82.0-0.60.8-1.1-0.70.9-0.9-0.61.4
Bone: elastic work0.30.30.8-0.20.7-0.6-0.00.9-0.9-0.10.5
Bone: endosteal estimation3.07.412.02.6-3.43.5-1.0-3.33.3-0.8-2.3
Bone: endosteal perimeter1.74.16.71.8-2.62.5-1.0-2.52.5-0.7-1.5
Epididymis fat weight1.36.312.7-3.62.7-3.30.62.4-2.40.52.6
Delta time in closed arm before/after self-admin1.00.91.9-0.21.0-1.0-0.21.4-1.4-0.31.2
Delta time in open arm before/after self-admin2.63.09.6-1.41.1-0.42.50.5-0.53.1-2.1
Diff in mean of infusions in LGA sessions1.83.14.91.9-2.22.0-1.9-1.81.8-1.3-1.1
Delay discount exponential model param1.21.62.1-1.51.5-1.31.21.3-1.31.40.1
Extinction: sum of active levers before priming0.30.41.00.6-0.70.80.1-0.70.70.3-1.0
Active lever presses in extinction session 61.31.32.50.8-1.31.2-0.6-1.61.6-0.0-1.2
Bone: final force0.20.30.80.9-0.60.8-0.4-0.40.4-0.2-0.6
Bone: final moment0.10.20.70.8-0.30.5-0.20.2-0.2-0.1-0.5
Food consumed during 24 hour testing period2.95.915.23.9-2.93.1-1.9-1.81.8-1.8-1.0
Glucose0.00.10.1-0.10.3-0.20.40.2-0.20.30.0
Heart weight0.81.23.10.2-0.80.2-1.8-1.31.3-1.50.7
Delay discount hyperbolic model param1.31.62.2-1.51.5-1.31.31.3-1.31.5-0.1
Intermittent access intake day 1-15 change0.52.75.60.9-1.71.0-2.4-1.71.7-2.20.1
Intermittent access intake escalation0.42.45.10.7-1.50.9-2.3-1.71.7-2.10.2
Intermittent access intake escalation 22.44.05.81.3-2.31.7-2.3-2.42.4-2.3-0.6
Intermitt. access day 1 inactive lever presses0.00.51.4-0.00.8-0.50.61.2-1.20.30.5
Intermitt. access day 15 inactive lever presses0.10.83.0-1.00.7-1.0-0.60.4-0.4-0.31.7
Intermitt. access escalation Index0.61.84.52.0-1.11.0-2.10.2-0.2-1.90.1
Intermittent access day 1 total infusions0.10.40.9-0.30.4-0.20.41.0-1.00.7-0.0
Intermittent access day 15 total infusions0.10.20.60.1-0.50.4-0.7-0.20.2-0.60.0
Intermittent access terminal intake (last 3 days)0.50.91.60.9-1.20.9-1.3-0.70.7-1.2-0.1
Intermittent access total infusions0.10.10.40.4-0.50.6-0.00.1-0.10.1-0.6
Intermittent access day 1 locomotion0.40.81.8-0.50.8-0.8-0.21.3-1.30.01.1
Intermittent access day 15 total locomotion0.00.20.3-0.10.3-0.30.30.6-0.60.00.5
Intermittent access total locomotion0.20.30.90.9-0.60.7-0.3-0.20.2-0.4-0.2
Intermittent access standard deviation0.10.41.3-0.1-0.60.2-1.1-0.50.5-0.80.5
Left kidney weight0.43.59.12.3-1.61.2-3.0-0.80.8-2.71.0
Right kidney weight0.32.36.21.5-1.20.7-2.5-1.01.0-2.21.1
Cocaine induced anxiety0.00.10.3-0.4-0.10.10.5-0.00.00.3-0.5
Post-drug Anxiety0.30.41.0-1.00.4-0.41.00.1-0.10.8-0.2
Baseline Anxiety0.81.32.3-1.51.5-1.41.10.7-0.71.00.8
Tail length0.20.92.2-0.70.1-0.9-1.3-0.20.2-1.21.5
Length with tail0.52.17.10.4-0.7-0.3-2.7-0.70.7-2.31.6
Length without tail1.36.615.43.1-2.51.7-3.9-1.71.7-3.50.9
Times rat made contact with spout1.82.16.02.4-1.61.8-1.1-1.01.0-1.1-0.5
Lifetime Intake0.10.10.2-0.1-0.30.40.20.2-0.20.3-0.5
Liver weight, left0.50.82.70.9-0.70.4-1.6-0.40.4-1.30.7
Liver weight, right1.11.95.31.3-1.10.5-2.3-0.80.8-2.01.4
Locomotor activity0.20.30.80.9-0.60.5-0.60.0-0.0-0.60.1
Locomotor testing distance0.10.21.11.0-0.20.5-0.10.3-0.3-0.1-0.2
Locomotor testing rearing0.00.10.50.70.10.2-0.10.5-0.50.10.1
Locomotion in novel chamber0.10.10.20.4-0.10.20.50.0-0.0-0.1-0.4
Locomotion in novel chamber post-restriction0.10.30.7-0.70.6-0.8-0.30.4-0.40.20.9
Fecal boli incidents, locomotor time 10.82.04.20.8-1.71.0-1.8-1.41.4-2.10.6
Change in fecal boli incidents, locomotor task1.92.16.10.70.20.82.00.0-0.02.2-2.5
Time >=10cm from walls, locomotor time 10.50.61.00.4-1.01.0-0.5-0.90.9-0.0-0.8
Bouts of movement, locomotor time 10.40.61.40.1-0.60.3-1.2-0.60.6-1.10.8
Total resting periods, locomotor time 10.40.41.10.4-0.60.5-1.1-0.50.5-0.90.6
Rest time, locomotor task time 11.22.05.32.3-0.90.9-1.9-0.00.0-2.01.0
Distance moved, locomotor task time 10.30.92.9-1.71.0-1.20.70.5-0.50.70.4
Vertical activity count, locomotor time 10.10.51.8-1.40.7-0.80.60.5-0.50.50.2
Time >=10cm from walls, locomotor time 20.10.20.50.7-0.20.1-0.70.4-0.4-0.60.4
Bouts of movement, locomotor time 20.31.13.5-1.20.7-1.2-1.00.5-0.5-0.91.9
Total resting periods, locomotor time 20.20.82.5-0.90.5-0.9-1.00.4-0.4-0.81.6
Rest time, locomotor task time 20.50.92.4-0.11.1-0.90.01.5-1.50.30.5
Distance moved, locomotor task time 20.10.20.4-0.6-0.1-0.20.4-0.60.6-0.00.4
Vertical activity count, locomotor time 20.10.10.30.1-0.50.4-0.1-0.50.5-0.50.1
Light reinforcement 11.14.811.11.8-2.11.5-3.3-1.91.9-3.01.0
Light reinforcement 20.20.41.50.5-0.30.80.50.3-0.30.5-1.2
Bone: marrow area3.07.412.32.7-3.43.5-1.0-3.23.2-0.8-2.3
Bone: maximum diameter4.18.214.73.4-3.63.8-1.5-3.03.0-1.3-2.1
Bone: maximum force0.30.61.21.0-0.91.1-0.3-0.70.7-0.1-0.9
Bone: maximum moment0.20.40.91.0-0.60.9-0.2-0.20.2-0.0-0.8
Mean time between licks in bursts0.00.10.2-0.30.2-0.3-0.00.5-0.50.10.0
Mean num. licks in bursts0.30.71.70.60.8-0.6-0.31.3-1.3-0.40.8
Cd content in liver1.82.06.1-1.51.3-2.0-0.90.5-0.5-0.82.5
Co content in liver1.72.06.30.00.4-1.0-2.00.8-0.8-1.72.5
Cu content in liver0.10.10.20.3-0.20.1-0.5-0.10.1-0.40.3
Fe content in liver3.13.89.5-0.0-1.21.82.1-2.12.12.0-3.1
K content in liver0.00.00.0-0.10.1-0.10.1-0.20.20.10.0
Mg content in liver0.30.40.60.7-0.60.7-0.3-0.80.8-0.3-0.4
Mn content in liver0.60.61.50.4-0.00.60.90.8-0.80.9-1.2
Na content in liver1.41.63.0-0.4-1.01.11.0-1.71.70.9-1.7
Rb content in liver0.50.61.40.1-0.50.50.6-1.21.20.6-0.9
Se content in liver1.01.23.6-0.80.8-0.21.90.5-0.51.7-1.3
Sr content in liver0.10.10.5-0.7-0.2-0.10.1-0.30.30.1-0.1
Zn content in liver0.91.01.8-0.81.1-1.3-0.11.2-1.2-0.11.2
Bone: minimum diameter0.20.31.11.1-0.60.7-0.50.1-0.1-0.3-0.3
Time in familiar zone, hab. session 11.31.52.50.9-1.61.5-0.5-1.61.6-0.6-0.9
Time in novel zone, hab. session 11.11.22.50.31.3-1.1-0.41.6-1.6-0.31.2
Total zone transitions, hab. session 11.41.97.7-2.81.4-1.90.70.3-0.30.71.1
Total locomotion distance, hab. session 12.13.09.9-3.11.9-2.40.90.8-0.80.71.4
Locomotion velocity, hab. session 11.52.18.0-2.81.4-1.90.90.5-0.50.80.9
Time in familiar zone, hab. session 20.10.10.60.8-0.30.5-0.0-0.20.20.1-0.3
Time in novel zone, hab. session 20.00.00.10.20.00.10.20.3-0.3-0.0-0.2
Total zone transitions, hab. session 21.11.45.7-2.40.5-1.4-0.1-0.70.7-0.31.4
Total locomotion distance, hab. session 21.41.97.9-2.80.8-1.8-0.1-0.20.2-0.31.7
Locomotion velocity, hab. session 21.52.08.8-3.01.0-1.90.10.0-0.0-0.11.6
Novel to familiar place preference ratio0.40.61.20.7-0.80.5-1.1-0.60.6-1.00.3
Novelty place preference0.91.22.11.3-1.21.0-1.4-0.90.9-1.30.2
Time in novel zone, NPP test1.41.73.71.9-1.41.4-1.6-1.01.0-1.4-0.0
Total zone transitions, NPP test0.40.62.1-1.40.2-0.7-0.1-0.80.8-0.10.6
Total locomotion distance, NPP test0.60.94.0-2.00.3-1.0-0.1-0.80.8-0.20.9
Locomotion velocity, NPP test1.11.68.2-2.90.7-1.50.5-0.50.50.30.8
Intraocular pressure0.30.51.20.70.1-0.1-1.10.1-0.1-1.11.0
Delta distance traveled before/after self-admin0.91.02.91.5-0.70.5-1.70.1-0.1-1.30.5
Delta ambulatory time before/after self-admin0.50.93.21.8-0.70.6-1.40.2-0.2-1.00.2
Parametrial fat weight1.02.24.0-2.01.5-2.0-0.11.5-1.5-0.31.7
Pavlov. Cond. lever latency1.62.05.10.31.8-1.20.82.3-2.30.60.5
Pavlov. Cond. magazine entry latency0.30.42.2-1.5-0.4-0.3-0.3-0.40.4-0.20.4
Pavlov. Cond. change in total contacts0.50.50.9-0.7-0.7-0.0-1.0-0.80.8-0.70.7
Pavlov. Cond. index score0.60.71.8-1.3-0.90.1-0.5-1.21.2-0.30.2
Pavlov. Cond. latency score0.60.71.5-1.2-0.90.2-0.5-1.21.2-0.30.1
Pavlov. Cond. lever contacts1.11.33.0-0.4-1.50.9-0.9-1.71.7-0.7-0.1
Pavlov. Cond. magazine entry number0.30.32.01.40.20.40.30.3-0.30.2-0.5
Pavlov. Cond. intertrial magazine entries0.30.31.0-0.30.1-0.00.4-1.01.00.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.70.81.9-1.4-0.90.2-0.5-1.31.3-0.40.2
Pavlov. Cond. response bias0.50.61.3-1.1-0.80.1-0.7-1.11.1-0.50.3
Pavlov. Cond. lever latency1.92.74.3-2.02.0-2.10.81.9-1.90.61.2
Pavlov. Cond. magazine entry latency1.11.63.4-1.10.9-0.41.81.1-1.11.9-1.2
Pavlov. Cond. change in total contacts0.10.20.60.8-0.60.7-0.1-0.40.40.1-0.5
Pavlov. Cond. index score0.50.72.00.6-0.81.10.5-0.60.60.7-1.4
Pavlov. Cond. latency score0.71.13.10.9-1.01.40.6-0.80.80.8-1.8
Pavlov. Cond. lever contacts1.82.74.52.1-2.02.1-0.8-1.81.8-0.6-1.2
Pavlov. Cond. magazine entry number0.91.23.10.5-0.2-0.2-1.8-0.30.3-1.81.6
Pavlov. Cond. intertrial magazine entries0.41.02.60.3-0.80.4-1.4-0.80.8-1.61.0
Pavlov. Cond. lever-magazine prob. diff.0.40.61.60.5-0.81.00.5-0.60.60.6-1.3
Pavlov. Cond. response bias0.30.50.90.4-0.70.80.3-0.80.80.5-0.9
Time in closed arm before self-admin0.71.22.10.6-1.41.4-0.2-1.51.5-0.1-1.0
Time in closed arm after self-admin0.20.30.7-0.50.5-0.6-0.00.5-0.5-0.10.8
Time in open arm before self-admin1.21.43.92.0-1.21.2-1.2-0.50.5-1.70.2
Time in open arm after self-admin1.82.07.10.9-0.81.41.5-0.80.81.4-2.7
Bone: periosteal estimation1.94.68.72.6-2.62.9-0.7-2.22.2-0.5-2.1
Bone: periosteal perimeter1.01.93.81.5-1.51.90.2-1.31.30.3-1.9
Bone: post-yield work1.93.35.41.6-2.22.3-0.5-2.32.3-0.3-1.7
Progressive ratio test 1 active lever presses0.20.30.70.8-0.50.5-0.60.4-0.4-0.4-0.3
Progressive ratio test 1 breakpoint0.20.30.91.0-0.60.6-0.60.4-0.4-0.5-0.4
Progressive ratio test 1 inactive lever presses0.10.20.70.20.1-0.1-0.10.8-0.80.10.2
Progressive ratio test 2 active lever presses0.20.20.50.5-0.70.7-0.7-0.10.1-0.3-0.2
Progressive ratio test 2 breakpoint0.10.20.40.4-0.60.5-0.6-0.00.0-0.2-0.1
Progressive ratio test 2 inactive lever presses0.10.20.5-0.00.2-0.20.50.7-0.70.5-0.0
Incentive Sensitization - Responses0.10.10.30.2-0.50.5-0.5-0.10.1-0.40.3
Incentive Sensitization - Breakpoint0.10.10.4-0.0-0.30.2-0.60.0-0.0-0.50.6
Sum of active levers in priming session hrs 5-60.80.81.41.1-0.81.0-0.0-1.01.00.4-1.2
Progressive ratio0.41.12.40.7-1.20.7-1.6-0.90.9-1.20.8
Food seeking constrained by brief footshock3.64.57.62.8-2.42.3-1.8-2.32.3-1.5-1.1
Seeking ratio, punishment vs. effort0.30.62.00.7-0.40.70.5-0.70.70.4-1.4
Retroperitoneal fat weight1.77.614.3-3.32.9-3.8-0.52.5-2.5-0.53.8
Reaction time number correct0.10.41.2-0.3-0.20.50.8-0.60.60.7-1.1
Reaction time mean minus median0.21.22.3-1.31.3-1.50.31.2-1.20.40.9
Reaction time mean minus median AUC0.10.81.4-1.11.1-1.20.61.0-1.00.70.2
Reaction time num false alarms0.81.42.0-1.41.4-1.21.31.1-1.11.20.1
Reaction time num false alarms AUC0.81.72.9-1.51.5-1.31.71.2-1.21.5-0.1
Reaction time trials correct on left0.10.41.2-0.3-0.20.50.8-0.60.60.7-1.1
Reaction time trials on left0.10.51.3-0.5-0.10.41.0-0.50.50.8-1.1
Reaction time mean0.40.91.7-0.91.0-0.90.71.3-1.30.70.1
Reaction time mean AUC0.30.60.9-0.80.8-0.80.61.0-1.00.7-0.1
Median of all reaction times0.50.81.7-0.80.9-0.70.81.3-1.30.8-0.1
Reaction time omissions2.74.47.3-2.72.4-2.32.22.0-2.02.00.4
Reaction time false alarm rate1.11.52.3-1.11.5-1.51.01.5-1.50.90.6
Reaction time premature initiation rate0.20.31.10.3-0.1-0.1-1.1-0.20.2-0.90.8
Reaction time premature initiations0.10.20.40.2-0.20.1-0.7-0.40.4-0.50.3
Std. dev. reaction times0.51.72.7-1.61.5-1.60.91.5-1.51.00.5
Reaction time trials completed0.10.51.3-0.5-0.10.41.0-0.50.50.8-1.1
Reaction time trials AUC0.20.51.5-0.4-0.20.51.0-0.60.60.8-1.2
Run reversals in cocaine runway, females0.91.02.7-0.01.1-0.60.61.6-1.60.70.5
Run reversals in cocaine runway, males0.70.72.30.1-0.90.6-0.3-1.51.5-0.30.0
Latency to leave start box in cocaine runway0.30.41.0-0.3-0.30.31.0-0.60.60.6-1.0
Latency to leave start box in cocaine runway, F0.00.00.1-0.1-0.20.10.1-0.30.3-0.2-0.2
Latency to leave start box in cocaine runway, M0.70.72.1-0.50.10.11.4-0.40.41.2-1.2
Std. dev. time between licks in bursts0.40.71.7-0.5-0.90.60.0-1.31.30.2-0.8
Total sessions with >9 infusions0.20.20.60.5-0.70.7-0.4-0.30.3-0.1-0.1
Short access day 1 total inactive lever presses0.30.61.30.7-0.10.1-1.10.6-0.6-1.00.9
Short access day 10 total inactive lever presses0.00.20.4-0.10.1-0.4-0.60.2-0.2-0.60.6
Short access day 1 total infusions0.00.10.2-0.1-0.40.4-0.1-0.20.20.1-0.3
Short access day 10 total infusions0.50.92.4-0.20.20.41.50.6-0.61.5-1.2
Short access total infusions0.30.40.9-0.70.3-0.10.90.7-0.70.9-0.4
Short access day 1 locomotion0.61.13.20.8-1.00.7-1.8-1.01.0-1.10.4
Short access day 10 total locomotion0.10.40.70.7-0.60.80.5-0.70.70.4-0.7
Short access total locomotion0.10.10.60.8-0.50.6-0.1-0.00.00.0-0.1
One hour access (0.3 mA shock)0.00.10.10.1-0.10.0-0.10.4-0.4-0.2-0.3
Compulsive drug intake0.60.81.81.20.00.71.20.5-0.51.0-1.3
One hour access (shock baseline)0.00.10.5-0.7-0.3-0.0-0.2-0.30.3-0.2-0.1
Social response proportion0.81.02.60.30.8-0.50.91.6-1.60.7-0.5
Social responses0.10.10.20.3-0.2-0.0-0.10.4-0.4-0.1-0.1
Social time0.20.30.90.20.10.10.70.6-0.60.6-1.0
Soleus weight5.917.328.93.8-5.04.4-3.3-5.45.4-3.2-1.0
Bone: stiffness0.10.20.5-0.1-0.10.20.5-0.50.50.4-0.7
Tibialis anterior weight2.910.117.63.1-3.73.6-1.7-4.24.2-1.6-1.7
Time to tail flick, vehicle, before self-admin0.10.10.3-0.60.4-0.40.20.1-0.10.40.0
Time to tail flick, vehicle, after self-admin0.71.32.81.1-1.11.50.8-1.11.10.5-1.7
Time to tail flick, test, before self-admin0.50.62.4-0.60.3-0.7-0.80.2-0.2-1.01.6
Time to tail flick, test, after self-admin1.41.53.61.2-1.20.8-1.9-0.80.8-1.80.5
Delta time to tail flick, vehicle, before/after SA1.11.21.80.7-1.21.30.6-1.41.40.3-1.3
Delta time to tail flick, test, before/after SA1.01.33.92.0-1.21.5-0.4-0.60.6-0.4-1.3
Tibia length1.23.38.12.8-2.22.3-2.0-0.60.6-1.9-0.4
Ambulatory time before self-admin0.30.91.7-0.1-0.91.00.6-1.31.30.3-1.2
Ambulatory time after self-admin1.72.74.42.1-2.02.1-0.7-1.61.6-0.5-1.7
Bone: tissue strength0.50.51.0-0.20.9-0.60.61.0-1.00.6-0.1
Total heroin consumption1.21.42.01.3-1.41.1-1.1-1.41.4-0.9-0.3
Bone: trabecular number0.30.72.3-1.50.1-0.21.0-0.40.41.0-0.7
Bone: trabecular spacing1.32.03.5-1.11.6-1.9-0.11.6-1.6-0.11.8
Bone: trabecular thickness0.10.20.70.8-0.10.2-0.30.4-0.4-0.4-0.2
Bone: trabecular tissue density0.30.41.21.10.3-0.1-0.70.8-0.8-0.50.5
Water consumed over 24 hours1.42.75.82.4-2.02.1-1.1-1.41.4-1.2-0.7
Number of responses in last shaping day2.93.76.52.0-2.41.8-2.6-1.91.9-1.8-0.2