Hub : Genes

Lysmd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Lysmd2 0.11 0.07 2.3e-05 0 0.03 0.03 0.02 2.4e-01 3.7e-04 1.7e-04 5.7e-03
2 LHb gene expression Lysmd2 0.26 0.12 2.9e-05 0.14 0.19 0.11 0.14 3.1e-04 2.9e-05 1.6e-03 3.8e-04
3 pVTA gene expression Lysmd2 0.08 0.04 6.1e-08 0.1 0.09 0.09 0.09 1.1e-08 6.4e-08 1.1e-07 7.1e-08
4 Brain alternative TSS XM_063265183.1 0.04 0.03 1.4e-03 0.04 0.03 0.03 0.04 3.1e-04 6.5e-04 6.1e-04 1.6e-04
5 PL intron excision ratio chr8_85260164_85272753 0.03 0.02 6.5e-03 0.02 0.02 0.01 0.01 1.0e-03 5.4e-03 7.9e-03 1.0e-02
6 PL intron excision ratio chr8_85273084_85274322 0.03 0.02 7.6e-04 0.04 0.03 0.04 0.04 3.4e-05 3.3e-04 7.1e-05 5.5e-05
7 NAcc alternative polyA XM_063265182.1 0.03 0.02 6.1e-03 0.01 0.01 0.01 0.01 9.7e-03 1.3e-02 2.4e-02 1.3e-02
8 Adipose gene expression Lysmd2 0.08 0.04 2.6e-06 0.03 0.02 0.02 0.02 8.1e-04 9.2e-04 1.3e-03 1.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.20.40.60.10.10.60.2-0.2-0.60.5
Area under the delay curve1.21.31.9-1.3-1.3-1.2-1.11.2-1.21.4-0.0
BMI with tail2.910.020.2-3.7-3.3-2.6-4.52.5-2.53.9-0.9
BMI without tail1.44.210.3-1.5-2.0-1.1-3.21.9-1.92.7-1.2
Body weight2.812.132.1-3.5-3.2-1.9-5.72.4-2.44.8-1.9
Weight adjusted by age1.31.93.3-1.3-1.8-1.7-0.91.4-1.41.50.5
Bone surface1.22.14.3-0.7-1.6-1.70.12.1-2.1-0.11.6
Bone volume0.50.91.9-0.5-1.2-1.1-0.21.4-1.40.20.9
Breakpoint value in progressive ratio session1.01.22.3-0.7-1.3-1.3-0.51.5-1.50.11.1
Number of licking bursts1.32.13.7-1.2-1.9-1.8-0.61.9-1.90.61.0
Context. condit. distance diff. score0.40.51.3-1.1-0.8-1.10.10.5-0.5-0.10.7
Locomotion velocity, session 10.50.61.1-0.8-0.7-0.4-1.00.7-0.71.0-0.5
Locomotion distance, session 10.60.83.92.00.50.80.70.3-0.3-0.60.0
Locomotion velocity, session 20.70.81.9-0.5-0.9-0.6-0.61.4-1.40.8-0.0
Locomotion distance, session 20.60.82.31.5-0.00.8-0.51.0-1.00.6-1.0
Locomotion velocity, session 31.71.95.21.30.1-0.12.30.9-0.9-1.91.7
Locomotion distance, session 32.72.96.72.61.61.52.4-0.40.4-2.30.7
Stereotopy head waving bouts, day 31.01.23.4-0.30.1-0.61.6-0.70.7-1.41.8
Stereotopy head waving duration, day 30.70.92.4-1.3-0.3-1.00.8-0.60.6-0.61.5
Locomotion velocity, session 70.30.31.20.60.30.21.1-0.10.1-0.60.2
Locomotion distance, session 70.20.20.60.4-0.2-0.10.40.8-0.8-0.20.3
Stereotopy head waving bouts, day 71.21.43.80.2-0.0-0.61.90.5-0.5-1.72.0
Stereotopy head waving duration, day 71.01.23.30.1-0.1-0.61.70.6-0.6-1.51.8
Locomotion velocity, session 80.50.61.60.1-0.5-0.40.61.3-1.3-0.50.7
Locomotion distance, session 80.50.72.00.6-0.7-0.40.41.4-1.4-0.30.4
Degree of sensitization distance1.91.93.5-1.9-1.5-1.3-1.80.8-0.81.7-0.4
Degree of sensitization stereotypy1.01.02.50.3-0.1-0.51.50.7-0.7-1.51.6
Conditioned locomotion0.60.71.70.40.40.9-0.7-0.90.90.9-1.3
Cocaine response after cond. corrected1.51.85.2-2.3-1.5-1.7-1.11.0-1.00.80.6
Cocaine response after cond. not corrected2.52.98.6-2.9-1.9-2.0-1.81.0-1.01.40.3
Cocaine response before conditioning1.51.73.7-1.6-1.5-1.1-1.90.8-0.81.6-0.4
Saline control response1.01.43.40.10.6-0.21.8-0.70.7-1.81.8
Bone: connectivity density1.21.85.72.41.11.11.8-0.30.3-1.80.6
Bone: cortical apparent density2.12.95.71.12.21.90.9-2.42.4-0.9-1.1
Bone: cortical area0.40.61.7-0.9-0.1-0.80.6-0.50.5-0.71.3
Bone: cortical porosity0.30.30.50.70.40.40.6-0.70.7-0.60.3
Bone: cortical porosity0.50.50.90.90.40.40.9-0.70.7-0.90.6
Bone: cortical thickness1.93.17.30.72.11.41.4-2.72.7-1.2-0.0
Bone: cortical thickness0.60.72.1-0.70.60.3-0.2-1.51.50.2-0.2
Bone: cortical tissue density2.02.75.11.12.11.90.8-2.32.3-0.8-1.1
Condit. Reinf. active minus inactive responses0.91.02.10.3-0.40.3-1.31.1-1.11.4-1.5
Condit. Reinf. active-inactive response ratio0.40.51.9-1.4-0.3-0.4-0.90.1-0.10.8-0.4
Condit. Reinf. active responses1.11.43.30.7-0.80.1-1.01.8-1.81.1-1.0
Condit. Reinf. inactive responses0.80.92.51.4-0.60.1-0.11.6-1.60.2-0.2
Incentive salience index mean1.21.53.30.0-1.4-0.7-1.21.8-1.81.2-0.5
Condit. Reinf. lever presses1.41.94.00.2-2.0-1.5-0.52.0-2.00.50.9
Condit. Reinf. active minus inactive responses0.60.82.5-1.6-0.8-1.1-0.10.9-0.9-0.20.9
Condit. Reinf. active-inactive response ratio0.60.71.8-1.0-0.0-0.71.0-0.10.1-1.11.3
Condit. Reinf. active responses1.42.03.4-1.9-1.5-1.2-1.61.4-1.41.3-0.2
Condit. Reinf. inactive responses1.92.55.8-0.9-1.5-0.7-2.41.4-1.42.3-1.3
Condit. Reinf. lever presses1.42.05.3-2.3-1.5-2.0-0.41.0-1.00.21.5
Condit. Reinf. lever reinforcers received1.21.73.4-1.9-1.3-1.1-1.61.2-1.21.3-0.3
Conditioned reinforcement - actives0.30.61.1-0.7-1.0-0.9-0.70.6-0.60.31.0
Conditioned reinforcement - inactives0.10.10.4-0.2-0.3-0.1-0.50.3-0.30.6-0.1
Conditioned locomotion0.30.40.7-0.00.30.5-0.7-0.70.70.5-0.9
Patch foraging indifference point 0 sec0.20.30.7-0.7-0.4-0.70.30.5-0.5-0.40.9
Patch foraging indifference point AUC0.81.23.41.40.41.3-1.2-0.10.10.8-1.9
Delay disc. indifference point, 0s delay0.40.41.00.90.10.5-0.40.6-0.60.5-1.0
Delay disc. indifference point, 16s delay0.10.10.3-0.6-0.0-0.1-0.5-0.30.30.6-0.3
Delay disc. indifference point, 2s delay0.60.71.7-1.0-0.8-0.6-0.60.8-0.81.3-0.6
Delay disc. indifference point, 24s delay0.10.10.3-0.3-0.3-0.3-0.50.1-0.10.6-0.1
Delay disc. indifference point, 4s delay0.70.71.3-0.7-1.0-0.9-0.61.1-1.10.80.2
Delay disc. indifference point, 8s delay3.13.65.1-1.9-2.3-1.8-2.02.0-2.02.10.0
Indifference point function ln k0.81.33.8-1.6-0.7-1.51.00.3-0.3-0.82.0
Indifference point function log k0.81.33.8-1.6-0.7-1.51.00.3-0.3-0.82.0
Patch foraging total patch changes 0 sec0.10.20.5-0.7-0.3-0.50.10.2-0.2-0.20.5
Patch foraging total patch changes 12 sec0.50.71.91.40.71.0-0.1-0.60.6-0.2-1.0
Patch foraging total patch changes 18 sec0.10.10.30.20.40.3-0.1-0.60.6-0.2-0.3
Patch foraging total patch changes 24 sec0.30.41.40.70.60.9-0.30.1-0.10.4-1.2
Patch foraging total patch changes 6 sec0.30.51.91.40.70.90.40.2-0.2-0.5-0.5
Patch foraging time to switch 0 sec0.50.92.21.20.70.41.5-0.60.6-1.30.7
Patch foraging water rate 0 sec0.91.95.9-2.4-1.2-1.2-1.60.8-0.81.5-0.3
Patch foraging water rate 12 sec0.71.64.4-2.1-1.2-1.3-0.91.2-1.20.80.7
Patch foraging water rate 18 sec0.40.61.4-0.70.70.7-0.4-0.80.80.7-1.2
Patch foraging water rate 24 sec0.10.10.2-0.10.50.30.5-0.50.5-0.20.0
Patch foraging water rate 6 sec1.01.53.1-1.8-1.3-1.3-0.71.5-1.50.70.6
Seeking ratio, delayed vs. immediate footshock3.84.69.3-1.6-2.6-2.3-1.33.1-3.11.01.1
Distance traveled before self-admin1.21.62.9-0.8-1.4-1.50.51.7-1.70.01.5
Distance traveled after self-admin2.42.94.6-2.0-2.1-2.1-0.71.9-1.90.61.6
Extensor digitorum longus weight1.04.07.8-1.1-2.1-1.4-2.12.8-2.82.1-0.3
Bone: elastic displacement0.70.82.00.60.81.1-0.7-0.90.90.6-1.4
Bone: elastic work0.30.30.80.10.70.6-0.0-0.90.90.1-0.5
Bone: endosteal estimation3.47.412.0-2.6-3.4-3.5-1.03.3-3.30.82.3
Bone: endosteal perimeter1.94.16.7-1.8-2.6-2.5-1.02.5-2.50.71.5
Epididymis fat weight1.86.312.43.52.73.30.6-2.42.4-0.5-2.6
Delta time in closed arm before/after self-admin1.00.91.90.21.01.0-0.2-1.41.40.3-1.2
Delta time in open arm before/after self-admin3.13.09.61.41.10.42.5-0.50.5-3.12.1
Diff in mean of infusions in LGA sessions2.63.14.9-1.9-2.2-2.0-1.91.8-1.81.31.1
Delay discount exponential model param1.41.62.11.41.51.31.2-1.31.3-1.4-0.1
Extinction: sum of active levers before priming0.40.41.0-0.6-0.7-0.80.10.7-0.7-0.31.0
Active lever presses in extinction session 61.31.32.5-0.8-1.3-1.2-0.61.6-1.60.01.2
Bone: final force0.20.30.9-0.9-0.6-0.8-0.40.4-0.40.20.6
Bone: final moment0.10.20.7-0.8-0.3-0.5-0.2-0.20.20.10.5
Food consumed during 24 hour testing period4.35.915.1-3.9-2.9-3.1-1.91.8-1.81.81.0
Glucose0.00.10.10.10.30.20.4-0.20.2-0.3-0.0
Heart weight0.81.23.1-0.3-0.8-0.2-1.81.3-1.31.5-0.7
Delay discount hyperbolic model param1.51.62.21.41.51.31.3-1.31.3-1.50.1
Intermittent access intake day 1-15 change1.32.75.6-0.9-1.7-1.0-2.41.7-1.72.2-0.1
Intermittent access intake escalation1.22.45.1-0.7-1.5-0.9-2.31.7-1.72.1-0.2
Intermittent access intake escalation 23.54.05.8-1.4-2.3-1.7-2.32.4-2.42.30.6
Intermitt. access day 1 inactive lever presses0.10.51.40.00.80.50.6-1.21.2-0.3-0.5
Intermitt. access day 15 inactive lever presses0.40.83.01.00.71.0-0.6-0.40.40.3-1.7
Intermitt. access escalation Index1.31.84.5-2.0-1.1-1.0-2.1-0.20.21.9-0.1
Intermittent access day 1 total infusions0.20.40.90.40.40.20.4-1.01.0-0.70.0
Intermittent access day 15 total infusions0.10.20.6-0.0-0.5-0.4-0.70.2-0.20.6-0.0
Intermittent access terminal intake (last 3 days)0.70.91.6-0.8-1.2-0.9-1.30.7-0.71.20.1
Intermittent access total infusions0.10.10.4-0.3-0.5-0.6-0.0-0.10.1-0.10.6
Intermittent access day 1 locomotion0.60.81.80.60.80.8-0.2-1.31.3-0.0-1.1
Intermittent access day 15 total locomotion0.10.20.30.10.30.30.3-0.60.6-0.0-0.5
Intermittent access total locomotion0.20.30.8-0.9-0.6-0.7-0.30.2-0.20.40.2
Intermittent access standard deviation0.20.41.30.1-0.6-0.2-1.10.5-0.50.8-0.5
Left kidney weight0.83.59.1-2.3-1.6-1.2-3.00.8-0.82.7-1.0
Right kidney weight0.52.36.2-1.5-1.2-0.7-2.51.0-1.02.2-1.1
Cocaine induced anxiety0.10.10.30.4-0.1-0.10.50.0-0.0-0.30.5
Post-drug Anxiety0.40.41.01.00.40.41.0-0.10.1-0.80.2
Baseline Anxiety1.11.32.31.41.51.41.1-0.70.7-1.0-0.8
Tail length0.20.82.20.70.10.9-1.30.2-0.21.2-1.5
Length with tail0.52.17.1-0.5-0.70.3-2.70.7-0.72.3-1.6
Length without tail2.16.715.4-3.2-2.5-1.7-3.91.7-1.73.5-0.9
Times rat made contact with spout1.82.15.9-2.4-1.6-1.8-1.11.0-1.01.10.5
Lifetime Intake0.10.10.20.1-0.3-0.40.2-0.20.2-0.30.5
Liver weight, left0.50.82.7-0.9-0.7-0.4-1.60.4-0.41.3-0.7
Liver weight, right1.11.95.3-1.3-1.1-0.5-2.30.8-0.82.0-1.4
Locomotor activity0.20.30.7-0.9-0.6-0.5-0.6-0.00.00.6-0.1
Locomotor testing distance0.10.21.1-1.0-0.2-0.5-0.1-0.30.30.10.2
Locomotor testing rearing0.10.10.5-0.70.1-0.2-0.1-0.50.5-0.1-0.1
Locomotion in novel chamber0.10.10.2-0.4-0.1-0.20.5-0.00.00.10.4
Locomotion in novel chamber post-restriction0.20.30.70.70.60.8-0.3-0.40.4-0.2-0.9
Fecal boli incidents, locomotor time 11.42.04.2-0.8-1.7-1.0-1.81.4-1.42.1-0.6
Change in fecal boli incidents, locomotor task2.12.16.1-0.70.2-0.82.0-0.00.0-2.22.5
Time >=10cm from walls, locomotor time 10.50.61.0-0.3-1.0-1.0-0.50.9-0.90.00.8
Bouts of movement, locomotor time 10.50.61.4-0.1-0.6-0.3-1.20.6-0.61.1-0.8
Total resting periods, locomotor time 10.40.41.1-0.4-0.6-0.5-1.10.5-0.50.9-0.6
Rest time, locomotor task time 11.62.05.4-2.3-0.9-0.9-1.90.0-0.02.0-1.0
Distance moved, locomotor task time 10.60.92.91.71.01.20.7-0.50.5-0.7-0.4
Vertical activity count, locomotor time 10.20.51.81.40.70.80.6-0.50.5-0.5-0.2
Time >=10cm from walls, locomotor time 20.10.20.5-0.6-0.2-0.1-0.7-0.40.40.6-0.4
Bouts of movement, locomotor time 20.71.13.51.20.71.2-1.0-0.50.50.9-1.9
Total resting periods, locomotor time 20.50.82.51.00.50.9-1.0-0.40.40.8-1.6
Rest time, locomotor task time 20.70.92.40.21.10.90.0-1.51.5-0.3-0.5
Distance moved, locomotor task time 20.20.20.40.6-0.10.20.40.6-0.60.0-0.4
Vertical activity count, locomotor time 20.10.10.3-0.1-0.5-0.4-0.10.5-0.50.5-0.1
Light reinforcement 12.04.811.1-1.9-2.1-1.5-3.31.9-1.93.0-1.0
Light reinforcement 20.20.41.5-0.4-0.3-0.80.5-0.30.3-0.51.2
Bone: marrow area3.47.412.3-2.7-3.4-3.5-1.03.2-3.20.82.3
Bone: maximum diameter4.48.214.7-3.5-3.6-3.8-1.53.0-3.01.32.1
Bone: maximum force0.40.61.2-1.0-0.9-1.1-0.30.7-0.70.10.9
Bone: maximum moment0.20.40.9-1.0-0.6-0.9-0.20.2-0.20.00.8
Mean time between licks in bursts0.00.10.20.30.20.3-0.0-0.50.5-0.1-0.0
Mean num. licks in bursts0.50.71.7-0.60.80.6-0.3-1.31.30.4-0.8
Cd content in liver1.82.06.11.41.32.0-0.9-0.50.50.8-2.5
Co content in liver1.72.06.3-0.10.41.0-2.0-0.80.81.7-2.5
Cu content in liver0.10.10.2-0.3-0.2-0.1-0.50.1-0.10.4-0.3
Fe content in liver3.23.89.5-0.0-1.2-1.82.12.1-2.1-2.03.1
K content in liver0.00.00.00.00.10.10.10.2-0.2-0.1-0.0
Mg content in liver0.40.40.6-0.8-0.6-0.7-0.30.8-0.80.30.4
Mn content in liver0.50.61.5-0.3-0.0-0.60.9-0.80.8-0.91.2
Na content in liver1.51.63.00.4-1.0-1.11.01.7-1.7-0.91.7
Rb content in liver0.50.61.4-0.2-0.5-0.50.61.2-1.2-0.60.9
Se content in liver1.01.23.60.80.80.21.9-0.50.5-1.71.3
Sr content in liver0.10.10.50.7-0.20.10.10.3-0.3-0.10.1
Zn content in liver0.91.01.80.81.11.3-0.1-1.21.20.1-1.2
Bone: minimum diameter0.20.31.1-1.0-0.6-0.7-0.5-0.10.10.30.3
Time in familiar zone, hab. session 11.51.52.5-0.8-1.6-1.5-0.51.6-1.60.60.9
Time in novel zone, hab. session 11.21.22.5-0.31.31.1-0.4-1.61.60.3-1.2
Total zone transitions, hab. session 11.41.97.52.71.41.90.7-0.30.3-0.7-1.1
Total locomotion distance, hab. session 12.13.09.63.11.92.40.9-0.80.8-0.7-1.4
Locomotion velocity, hab. session 11.42.07.82.81.41.90.9-0.50.5-0.8-0.9
Time in familiar zone, hab. session 20.10.10.6-0.8-0.3-0.5-0.00.2-0.2-0.10.3
Time in novel zone, hab. session 20.00.00.1-0.20.0-0.10.2-0.30.30.00.2
Total zone transitions, hab. session 21.01.35.42.30.51.4-0.10.7-0.70.3-1.4
Total locomotion distance, hab. session 21.41.87.72.80.81.8-0.10.2-0.20.3-1.7
Locomotion velocity, hab. session 21.52.08.72.91.01.90.1-0.00.00.1-1.6
Novel to familiar place preference ratio0.50.61.2-0.7-0.8-0.5-1.10.6-0.61.0-0.3
Novelty place preference1.11.22.1-1.3-1.2-1.0-1.40.9-0.91.3-0.2
Time in novel zone, NPP test1.61.73.6-1.9-1.4-1.4-1.61.0-1.01.40.0
Total zone transitions, NPP test0.40.51.91.40.20.7-0.10.8-0.80.1-0.6
Total locomotion distance, NPP test0.60.93.82.00.31.0-0.10.8-0.80.2-0.9
Locomotion velocity, NPP test1.11.68.12.80.71.50.50.5-0.5-0.3-0.8
Intraocular pressure0.30.51.2-0.80.10.1-1.1-0.10.11.1-1.0
Delta distance traveled before/after self-admin0.91.02.9-1.5-0.7-0.5-1.7-0.10.11.3-0.5
Delta ambulatory time before/after self-admin0.70.93.1-1.8-0.7-0.6-1.4-0.20.21.0-0.2
Parametrial fat weight1.02.34.12.01.52.0-0.1-1.51.50.3-1.7
Pavlov. Cond. lever latency1.62.15.1-0.31.81.20.8-2.32.3-0.6-0.5
Pavlov. Cond. magazine entry latency0.30.42.41.5-0.40.3-0.30.4-0.40.2-0.4
Pavlov. Cond. change in total contacts0.50.50.90.8-0.70.0-1.00.8-0.80.7-0.7
Pavlov. Cond. index score0.60.71.91.4-0.9-0.1-0.51.2-1.20.3-0.2
Pavlov. Cond. latency score0.60.71.51.2-0.9-0.2-0.51.2-1.20.3-0.1
Pavlov. Cond. lever contacts1.11.33.00.4-1.5-0.9-0.91.7-1.70.70.1
Pavlov. Cond. magazine entry number0.30.42.1-1.50.2-0.40.3-0.30.3-0.20.5
Pavlov. Cond. intertrial magazine entries0.30.31.00.20.10.00.41.0-1.0-0.30.3
Pavlov. Cond. lever-magazine prob. diff.0.70.82.11.4-0.9-0.2-0.51.3-1.30.4-0.2
Pavlov. Cond. response bias0.50.61.41.2-0.8-0.1-0.71.1-1.10.5-0.3
Pavlov. Cond. lever latency2.02.74.32.02.02.10.8-1.91.9-0.6-1.2
Pavlov. Cond. magazine entry latency1.31.63.41.10.90.41.8-1.11.1-1.91.2
Pavlov. Cond. change in total contacts0.10.20.6-0.8-0.6-0.7-0.10.4-0.4-0.10.5
Pavlov. Cond. index score0.50.72.0-0.6-0.8-1.10.50.6-0.6-0.71.4
Pavlov. Cond. latency score0.91.13.1-0.9-1.0-1.40.60.8-0.8-0.81.8
Pavlov. Cond. lever contacts2.02.74.5-2.1-2.0-2.1-0.81.8-1.80.61.2
Pavlov. Cond. magazine entry number0.91.23.1-0.5-0.20.2-1.80.3-0.31.8-1.6
Pavlov. Cond. intertrial magazine entries0.61.02.6-0.3-0.8-0.4-1.40.8-0.81.6-1.0
Pavlov. Cond. lever-magazine prob. diff.0.40.61.6-0.5-0.8-1.00.50.6-0.6-0.61.3
Pavlov. Cond. response bias0.30.50.9-0.4-0.7-0.80.30.8-0.8-0.50.9
Time in closed arm before self-admin0.91.22.1-0.5-1.4-1.4-0.21.5-1.50.11.0
Time in closed arm after self-admin0.20.30.70.60.50.6-0.0-0.50.50.1-0.8
Time in open arm before self-admin1.31.43.8-2.0-1.2-1.2-1.20.5-0.51.7-0.2
Time in open arm after self-admin1.82.07.1-0.9-0.8-1.41.50.8-0.8-1.42.7
Bone: periosteal estimation2.24.68.7-2.6-2.6-2.9-0.72.2-2.20.52.1
Bone: periosteal perimeter1.11.93.8-1.5-1.5-1.90.21.3-1.3-0.31.9
Bone: post-yield work2.33.35.4-1.6-2.2-2.3-0.52.3-2.30.31.7
Progressive ratio test 1 active lever presses0.20.20.6-0.7-0.5-0.5-0.6-0.40.40.40.3
Progressive ratio test 1 breakpoint0.30.30.7-0.9-0.6-0.6-0.6-0.40.40.50.4
Progressive ratio test 1 inactive lever presses0.10.20.7-0.20.10.1-0.1-0.80.8-0.1-0.2
Progressive ratio test 2 active lever presses0.20.20.5-0.5-0.7-0.7-0.70.1-0.10.30.2
Progressive ratio test 2 breakpoint0.10.10.4-0.3-0.6-0.5-0.60.0-0.00.20.1
Progressive ratio test 2 inactive lever presses0.10.20.50.10.20.20.5-0.70.7-0.50.0
Incentive Sensitization - Responses0.10.10.3-0.2-0.5-0.5-0.50.1-0.10.4-0.3
Incentive Sensitization - Breakpoint0.10.10.40.0-0.3-0.2-0.6-0.00.00.5-0.6
Sum of active levers in priming session hrs 5-60.80.81.4-1.1-0.8-1.0-0.01.0-1.0-0.41.2
Progressive ratio0.71.12.4-0.7-1.2-0.7-1.60.9-0.91.2-0.8
Food seeking constrained by brief footshock3.74.68.0-2.8-2.4-2.3-1.82.3-2.31.51.1
Seeking ratio, punishment vs. effort0.40.62.0-0.8-0.4-0.70.50.7-0.7-0.41.4
Retroperitoneal fat weight1.87.514.33.22.93.8-0.5-2.52.50.5-3.8
Reaction time number correct0.20.41.20.3-0.2-0.50.80.6-0.6-0.71.1
Reaction time mean minus median0.51.22.31.31.31.50.3-1.21.2-0.4-0.9
Reaction time mean minus median AUC0.30.81.41.11.11.20.6-1.01.0-0.7-0.2
Reaction time num false alarms1.01.42.01.41.41.21.3-1.11.1-1.2-0.1
Reaction time num false alarms AUC1.11.72.91.51.51.31.7-1.21.2-1.50.1
Reaction time trials correct on left0.20.41.20.3-0.2-0.50.80.6-0.6-0.71.1
Reaction time trials on left0.30.51.30.4-0.1-0.41.00.5-0.5-0.81.1
Reaction time mean0.60.91.71.01.00.90.7-1.31.3-0.7-0.1
Reaction time mean AUC0.40.60.90.90.80.80.6-1.01.0-0.70.1
Median of all reaction times0.60.91.70.90.90.70.8-1.31.3-0.80.1
Reaction time omissions3.04.47.22.72.42.32.2-2.02.0-2.0-0.4
Reaction time false alarm rate1.11.52.31.11.51.51.0-1.51.5-0.9-0.6
Reaction time premature initiation rate0.30.31.1-0.4-0.10.1-1.10.2-0.20.9-0.8
Reaction time premature initiations0.10.20.4-0.2-0.2-0.1-0.70.4-0.40.5-0.3
Std. dev. reaction times0.91.72.71.61.51.60.9-1.51.5-1.0-0.5
Reaction time trials completed0.30.51.30.4-0.1-0.41.00.5-0.5-0.81.1
Reaction time trials AUC0.30.51.50.3-0.2-0.51.00.6-0.6-0.81.2
Run reversals in cocaine runway, females1.01.02.70.11.10.60.6-1.61.6-0.7-0.5
Run reversals in cocaine runway, males0.70.72.3-0.2-0.9-0.6-0.31.5-1.50.3-0.0
Latency to leave start box in cocaine runway0.40.41.00.3-0.3-0.31.00.6-0.6-0.61.0
Latency to leave start box in cocaine runway, F0.00.00.10.1-0.2-0.10.10.3-0.30.20.2
Latency to leave start box in cocaine runway, M0.70.72.10.50.1-0.11.40.4-0.4-1.21.2
Std. dev. time between licks in bursts0.50.71.70.6-0.9-0.60.01.3-1.3-0.20.8
Total sessions with >9 infusions0.20.20.6-0.4-0.7-0.7-0.40.3-0.30.10.1
Short access day 1 total inactive lever presses0.40.61.3-0.7-0.1-0.1-1.1-0.60.61.0-0.9
Short access day 10 total inactive lever presses0.10.20.40.10.10.4-0.6-0.20.20.6-0.6
Short access day 1 total infusions0.00.10.20.1-0.4-0.4-0.10.2-0.2-0.10.3
Short access day 10 total infusions0.70.92.40.30.2-0.41.5-0.60.6-1.51.2
Short access total infusions0.30.40.90.80.30.10.9-0.70.7-0.90.4
Short access day 1 locomotion0.91.13.2-0.8-1.0-0.7-1.81.0-1.01.1-0.4
Short access day 10 total locomotion0.20.40.7-0.6-0.6-0.80.50.7-0.7-0.40.7
Short access total locomotion0.10.10.5-0.7-0.5-0.6-0.10.0-0.0-0.00.1
One hour access (0.3 mA shock)0.00.10.1-0.1-0.1-0.0-0.1-0.40.40.20.3
Compulsive drug intake0.70.81.8-1.20.0-0.71.2-0.50.5-1.01.3
One hour access (shock baseline)0.10.10.60.8-0.30.0-0.20.3-0.30.20.1
Social response proportion0.91.02.6-0.20.80.50.9-1.61.6-0.70.5
Social responses0.00.10.2-0.3-0.20.0-0.1-0.40.40.10.1
Social time0.20.30.9-0.10.1-0.10.7-0.60.6-0.61.0
Soleus weight5.917.428.9-3.9-5.0-4.4-3.35.4-5.43.21.0
Bone: stiffness0.10.20.50.0-0.1-0.20.50.5-0.5-0.40.7
Tibialis anterior weight3.010.117.6-3.2-3.7-3.6-1.74.2-4.21.61.7
Time to tail flick, vehicle, before self-admin0.10.10.30.50.40.40.2-0.10.1-0.4-0.0
Time to tail flick, vehicle, after self-admin1.01.32.8-1.1-1.1-1.50.81.1-1.1-0.51.7
Time to tail flick, test, before self-admin0.60.62.40.70.30.7-0.8-0.20.21.0-1.6
Time to tail flick, test, after self-admin1.41.53.6-1.2-1.2-0.8-1.90.8-0.81.8-0.5
Delta time to tail flick, vehicle, before/after SA1.31.21.8-0.7-1.2-1.30.61.4-1.4-0.31.3
Delta time to tail flick, test, before/after SA1.21.33.9-2.0-1.2-1.5-0.40.6-0.60.41.3
Tibia length1.23.27.7-2.8-2.2-2.3-2.00.6-0.61.90.4
Ambulatory time before self-admin0.60.91.70.1-0.9-1.00.61.3-1.3-0.31.2
Ambulatory time after self-admin2.32.74.4-2.1-2.0-2.1-0.71.6-1.60.51.7
Bone: tissue strength0.50.51.00.10.90.60.6-1.01.0-0.60.1
Total heroin consumption1.21.42.0-1.4-1.4-1.1-1.11.4-1.40.90.3
Bone: trabecular number0.40.72.31.50.10.21.00.4-0.4-1.00.7
Bone: trabecular spacing1.52.03.51.11.61.9-0.1-1.61.60.1-1.8
Bone: trabecular thickness0.10.20.7-0.8-0.1-0.2-0.3-0.40.40.40.2
Bone: trabecular tissue density0.30.41.2-1.10.30.1-0.7-0.80.80.5-0.5
Water consumed over 24 hours2.02.75.7-2.4-2.0-2.1-1.11.4-1.41.20.7
Number of responses in last shaping day3.43.76.5-1.9-2.4-1.8-2.61.9-1.91.80.2