Hub : Genes

Lrrc8e

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Lrrc8e	0.38	0.13	2.2e-11	0.1	0.11	0.11	0.12	9.9e-12	4.2e-13	3.9e-13	2.2e-13
2	PL	gene expression	Lrrc8e	0.37	0.14	6.3e-09	0.06	0.09	0.09	0.09	5.9e-07	4.0e-10	1.1e-09	8.0e-10
3	BLA	gene expression	Lrrc8e	0.66	0.12	8.5e-06	0.03	0.08	0.07	0.09	6.8e-03	6.3e-05	2.0e-04	1.5e-05
4	Brain	gene expression	Lrrc8e	0.26	0.13	4.2e-06	0.05	0.05	0.08	0.08	9.1e-06	2.2e-05	1.1e-07	1.2e-07
5	pVTA	gene expression	Lrrc8e	0.61	0.15	9.9e-06	0.09	0.14	0.14	0.14	7.2e-05	8.9e-07	1.7e-06	1.1e-06
6	Adipose	gene expression	Lrrc8e	0.12	0.07	3.7e-10	0.04	0.06	0.05	0.05	1.3e-05	3.4e-07	4.2e-06	5.4e-06
7	Liver	gene expression	Lrrc8e	0.87	0.08	0.0e+00	0.2	0.26	0.28	0.27	1.6e-21	2.9e-28	1.7e-30	6.4e-30

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	4.4	7.4	12.5	-3.3	-3.3	-3.5	3.0	-2.8	0.3	0.9
Area under the delay curve	0.3	0.4	1.4	0.7	0.2	0.1	-0.5	0.4	1.2	-0.3
BMI with tail	3.4	10.9	17.2	-3.9	-4.1	-3.5	3.6	-3.6	1.1	2.1
BMI without tail	3.0	6.3	10.4	-3.2	-3.2	-2.6	2.6	-2.8	-0.3	1.2
Body weight	11.0	46.1	74.3	-8.6	-8.5	-7.3	7.3	-7.5	-1.2	3.5
Weight adjusted by age	0.7	0.8	2.0	-0.9	-1.1	-0.5	0.6	-1.4	-0.8	0.5
Bone surface	5.9	10.5	15.8	-4.0	-3.9	-3.9	3.9	-3.3	0.3	1.4
Bone volume	4.9	8.3	13.4	-3.3	-3.4	-3.7	3.5	-2.8	0.9	1.2
Breakpoint value in progressive ratio session	0.8	0.9	3.2	-0.1	-0.5	-1.8	0.2	-0.1	1.5	-0.5
Number of licking bursts	2.1	2.5	10.9	-0.5	0.5	2.4	-0.1	-0.2	-3.3	0.6
Context. condit. distance diff. score	2.8	3.4	11.3	-1.9	-1.9	-3.4	1.4	-1.0	1.4	0.1
Locomotion velocity, session 1	0.3	0.3	0.6	0.8	0.4	0.2	-0.8	0.4	0.6	-0.4
Locomotion distance, session 1	1.1	1.4	3.1	1.6	1.2	1.0	-1.8	1.1	0.4	-0.6
Locomotion velocity, session 2	0.4	0.5	1.1	0.7	0.5	1.1	-1.0	0.3	-0.6	0.1
Locomotion distance, session 2	2.5	3.4	7.4	2.1	2.1	1.6	-2.7	1.9	-0.3	-1.3
Locomotion velocity, session 3	0.5	0.5	1.9	-0.5	-0.8	-1.4	0.2	-0.4	0.9	0.2
Locomotion distance, session 3	0.2	0.2	0.5	0.2	0.4	-0.2	-0.7	0.5	0.2	-0.5
Stereotopy head waving bouts, day 3	1.3	1.5	2.6	-1.6	-1.6	-1.2	1.0	-1.6	-0.6	0.4
Stereotopy head waving duration, day 3	0.4	0.5	1.0	-0.5	-0.8	-0.1	0.6	-1.0	-0.1	0.9
Locomotion velocity, session 7	0.1	0.1	0.2	0.1	0.2	0.4	-0.4	0.2	0.3	0.4
Locomotion distance, session 7	0.2	0.3	0.7	0.5	0.7	-0.1	-0.7	0.8	0.4	-0.3
Stereotopy head waving bouts, day 7	0.6	0.6	1.3	1.1	0.7	0.3	-0.9	0.7	0.6	-1.0
Stereotopy head waving duration, day 7	0.3	0.4	0.9	1.0	0.6	0.7	-0.7	0.4	0.2	-0.5
Locomotion velocity, session 8	0.1	0.2	0.4	-0.5	-0.4	-0.1	0.1	-0.4	-0.1	0.6
Locomotion distance, session 8	0.6	0.9	2.5	-1.2	-1.0	-1.6	0.5	-0.6	0.5	0.6
Degree of sensitization distance	0.4	0.4	1.0	0.9	0.8	1.0	-0.3	0.6	-0.2	0.1
Degree of sensitization stereotypy	0.3	0.3	0.6	0.7	0.4	0.2	-0.4	0.5	0.6	-0.7
Conditioned locomotion	0.2	0.2	0.8	-0.0	-0.2	-0.9	-0.2	0.2	0.9	-0.3
Cocaine response after cond. corrected	3.2	3.6	6.5	-1.8	-2.1	-0.3	2.4	-2.3	-0.0	2.6
Cocaine response after cond. not corrected	3.3	3.7	6.1	-1.9	-2.2	-1.4	2.5	-2.1	1.1	2.0
Cocaine response before conditioning	1.7	2.0	5.1	0.2	0.2	-2.2	-0.3	0.9	2.3	-1.8
Saline control response	0.9	1.1	2.8	0.1	0.9	0.3	-1.5	0.6	-1.7	-1.2
Bone: connectivity density	5.0	7.8	12.6	-3.5	-3.4	-3.5	3.0	-2.8	-0.3	1.1
Bone: cortical apparent density	0.2	0.2	0.9	-0.1	-0.5	0.0	0.2	-0.5	0.4	1.0
Bone: cortical area	2.0	3.1	6.2	-2.0	-2.1	-2.5	1.9	-1.6	0.7	0.5
Bone: cortical porosity	0.1	0.1	0.2	0.2	0.2	0.2	-0.5	-0.0	-0.3	-0.2
Bone: cortical porosity	0.6	0.7	1.3	1.0	1.0	0.3	-1.2	0.8	0.3	-0.8
Bone: cortical thickness	1.8	2.9	4.6	-2.0	-2.1	-2.1	1.9	-1.6	0.4	0.9
Bone: cortical thickness	0.3	0.3	0.6	-0.7	-0.5	-0.7	0.8	-0.4	-0.5	0.0
Bone: cortical tissue density	0.2	0.2	0.9	-0.0	-0.5	0.1	0.2	-0.5	0.3	1.0
Condit. Reinf. active minus inactive responses	0.2	0.2	1.1	0.5	0.2	-0.2	0.3	0.2	1.0	-0.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.3	-0.2	-0.5	-0.8	1.0	-0.4	1.1	0.1
Condit. Reinf. active responses	0.8	1.0	1.4	1.2	1.0	-0.2	-0.8	1.1	1.1	-1.1
Condit. Reinf. inactive responses	2.6	3.1	5.5	2.1	1.9	0.5	-2.3	2.0	0.7	-1.8
Incentive salience index mean	0.8	1.0	2.1	1.1	0.9	-0.4	-0.5	1.1	1.4	-1.0
Condit. Reinf. lever presses	1.1	1.5	2.5	1.3	1.0	-0.7	-0.9	1.4	1.6	-1.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.6	-0.2	-0.7	0.8	-0.0	-0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.1	0.5	0.2	-0.2	0.5	-0.5	-0.3
Condit. Reinf. active responses	0.6	0.8	2.7	-0.7	-0.3	-1.7	1.0	0.1	0.6	-0.8
Condit. Reinf. inactive responses	0.5	0.7	2.4	-0.5	-0.3	-1.5	0.6	0.1	0.9	-0.8
Condit. Reinf. lever presses	0.7	1.0	3.4	-0.3	-0.4	-1.9	0.7	0.2	1.4	-0.9
Condit. Reinf. lever reinforcers received	0.4	0.6	1.8	-0.4	0.0	-1.3	0.6	0.4	0.6	-1.0
Conditioned reinforcement - actives	0.6	0.6	2.5	-0.9	-0.7	-0.6	0.3	-0.5	-1.6	-0.2
Conditioned reinforcement - inactives	0.4	0.4	1.8	0.1	0.4	0.9	-0.2	0.3	-1.3	-0.1
Conditioned locomotion	0.4	0.4	1.5	-0.3	-0.2	-1.2	-0.2	0.2	-0.4	-1.1
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.1	0.1	0.0	-0.1	0.2	-0.1	-0.2
Patch foraging indifference point AUC	0.1	0.1	0.5	-0.7	0.1	-0.3	0.2	0.2	-0.6	-0.1
Delay disc. indifference point, 0s delay	2.5	2.8	4.6	-1.5	-2.0	-0.5	2.1	-2.0	0.3	2.1
Delay disc. indifference point, 16s delay	0.3	0.3	0.5	0.6	0.4	0.5	-0.7	0.6	0.4	-0.3
Delay disc. indifference point, 2s delay	1.0	1.1	6.2	0.7	-0.1	-0.8	0.4	0.2	2.5	-0.1
Delay disc. indifference point, 24s delay	0.7	0.7	1.3	1.0	0.8	1.1	-1.0	0.9	-0.0	-0.3
Delay disc. indifference point, 4s delay	0.5	0.6	3.2	0.7	-0.0	-0.4	0.0	0.3	1.8	-0.1
Delay disc. indifference point, 8s delay	1.0	1.1	2.1	1.1	0.9	0.3	-1.4	1.1	0.9	-1.1
Indifference point function ln k	0.5	0.7	1.9	0.9	0.8	0.4	-1.4	0.5	-0.5	-1.0
Indifference point function log k	0.5	0.7	1.9	0.9	0.8	0.4	-1.4	0.5	-0.5	-1.0
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	0.2	0.5	0.2	-0.4	0.7	-0.1	-0.6
Patch foraging total patch changes 12 sec	0.1	0.2	0.4	-0.6	-0.4	-0.6	0.1	-0.3	0.1	0.2
Patch foraging total patch changes 18 sec	0.1	0.2	0.5	-0.4	0.3	0.3	0.3	0.3	-0.7	0.2
Patch foraging total patch changes 24 sec	1.7	2.1	4.7	1.0	1.8	0.1	-1.4	2.2	0.4	-1.9
Patch foraging total patch changes 6 sec	0.1	0.1	0.3	-0.5	0.1	-0.4	-0.0	0.3	-0.0	-0.4
Patch foraging time to switch 0 sec	1.6	2.5	6.1	-0.9	-1.6	0.5	2.0	-1.7	0.9	2.5
Patch foraging water rate 0 sec	0.8	1.3	4.2	0.0	0.8	-0.8	-1.2	1.0	-1.1	-2.1
Patch foraging water rate 12 sec	1.6	2.4	4.8	1.5	1.6	0.0	-2.1	1.7	-0.0	-2.2
Patch foraging water rate 18 sec	3.3	4.4	8.4	2.2	2.2	0.2	-2.9	2.3	0.6	-2.7
Patch foraging water rate 24 sec	0.9	1.2	4.1	0.4	0.8	-0.8	-1.5	0.8	-0.5	-2.0
Patch foraging water rate 6 sec	1.0	1.4	4.2	0.8	0.8	-1.2	-1.1	1.2	0.8	-2.0
Seeking ratio, delayed vs. immediate footshock	1.9	2.1	7.2	1.2	1.6	2.7	-0.9	1.2	-1.1	0.7
Distance traveled before self-admin	0.9	0.9	1.5	1.0	1.2	0.2	-0.9	1.2	0.9	-1.0
Distance traveled after self-admin	0.3	0.4	0.9	0.4	0.7	0.1	-0.5	0.9	0.2	-0.9
Extensor digitorum longus weight	2.2	8.7	21.7	-3.8	-3.2	-4.7	3.0	-2.2	0.4	-0.4
Bone: elastic displacement	0.1	0.2	0.3	-0.3	-0.4	-0.3	-0.3	-0.5	-0.6	-0.3
Bone: elastic work	1.3	1.7	3.3	-1.8	-1.6	-1.8	0.8	-1.3	-0.6	-0.4
Bone: endosteal estimation	0.2	0.4	1.1	-0.9	-0.4	-0.5	0.5	-0.4	-1.0	-0.4
Bone: endosteal perimeter	0.4	0.9	3.4	-0.9	-0.5	-1.8	0.6	-0.1	0.5	-1.1
Epididymis fat weight	0.6	1.3	4.4	-0.1	-0.4	-2.1	0.1	0.3	2.0	-0.8
Delta time in closed arm before/after self-admin	0.2	0.2	0.6	0.2	0.8	-0.1	0.1	0.7	-0.1	-0.6
Delta time in open arm before/after self-admin	0.5	0.5	1.7	0.7	0.4	0.4	-0.6	0.4	1.3	0.1
Diff in mean of infusions in LGA sessions	0.6	0.7	1.2	0.6	0.3	-1.0	-1.1	0.5	1.0	-0.9
Delay discount exponential model param	0.7	0.7	2.1	-1.0	-0.5	-0.0	0.8	-0.8	-1.4	0.7
Extinction: sum of active levers before priming	0.6	0.6	1.9	0.9	0.5	-0.1	-0.3	0.9	1.4	-0.3
Active lever presses in extinction session 6	0.4	0.4	0.9	-0.5	-0.6	-0.9	0.9	-0.2	0.4	-0.2
Bone: final force	1.2	2.0	3.7	-1.9	-1.7	-1.2	1.4	-1.6	-1.1	0.7
Bone: final moment	1.0	1.6	3.0	-1.7	-1.4	-0.9	1.1	-1.4	-1.2	0.6
Food consumed during 24 hour testing period	0.2	0.3	1.2	0.1	0.4	0.6	-0.1	0.1	-1.1	0.1
Glucose	0.2	0.3	0.9	-0.1	-0.6	0.4	0.5	-0.7	0.1	0.9
Heart weight	4.8	6.8	10.2	2.4	3.2	1.6	-3.1	3.2	-1.1	-2.9
Delay discount hyperbolic model param	0.5	0.6	2.1	-0.9	-0.4	-0.0	0.5	-0.6	-1.5	0.5
Intermittent access intake day 1-15 change	0.5	0.5	2.4	-0.6	-0.4	0.3	0.3	-0.5	-1.6	0.2
Intermittent access intake escalation	0.2	0.2	1.3	-0.4	-0.2	0.0	0.0	-0.2	-1.1	-0.2
Intermittent access intake escalation 2	0.2	0.2	0.3	0.3	0.3	0.5	-0.3	0.4	-0.5	-0.4
Intermitt. access day 1 inactive lever presses	0.8	0.8	1.7	0.3	1.1	1.1	-0.5	1.0	-1.3	-0.5
Intermitt. access day 15 inactive lever presses	1.3	1.5	2.7	-1.0	-1.3	0.3	1.6	-1.6	-0.4	1.5
Intermitt. access escalation Index	1.8	1.6	2.9	1.1	1.4	0.1	-1.7	1.5	0.8	-1.4
Intermittent access day 1 total infusions	1.5	1.8	2.9	1.7	1.4	0.7	-1.3	1.7	1.0	-1.3
Intermittent access day 15 total infusions	0.6	0.7	1.4	0.9	0.8	0.4	-0.8	1.0	-0.0	-1.2
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.6	0.8	0.5	0.7	-0.3	0.6	0.1	-0.5
Intermittent access total infusions	0.5	0.6	1.1	1.1	0.6	0.4	-0.5	0.9	0.8	-0.8
Intermittent access day 1 locomotion	3.2	3.4	4.9	2.1	1.6	-0.1	-2.1	2.0	2.2	-1.9
Intermittent access day 15 total locomotion	3.7	4.0	7.3	2.0	1.9	-0.2	-2.4	2.4	1.1	-2.7
Intermittent access total locomotion	3.9	4.4	6.5	2.4	2.1	0.1	-2.3	2.6	1.8	-2.4
Intermittent access standard deviation	1.1	1.1	1.9	-0.9	-1.2	0.2	1.3	-1.4	-1.0	1.0
Left kidney weight	3.0	8.5	16.3	-4.0	-3.4	-3.5	2.5	-2.9	-2.1	0.6
Right kidney weight	3.4	9.6	18.5	-4.3	-3.7	-3.2	2.7	-3.4	-2.0	1.4
Cocaine induced anxiety	1.0	1.2	4.2	0.5	0.4	-1.3	-0.3	0.9	2.0	-1.1
Post-drug Anxiety	0.9	1.0	4.2	1.2	0.7	0.1	-0.4	0.9	2.1	-0.4
Baseline Anxiety	0.5	0.6	2.0	0.7	0.1	1.4	0.1	-0.2	0.4	1.1
Tail length	3.0	9.1	16.2	-4.0	-3.7	-3.8	2.6	-3.2	-1.6	0.5
Length with tail	7.5	27.5	48.3	-7.0	-6.4	-6.0	5.4	-5.5	-2.4	1.7
Length without tail	7.0	15.4	25.0	-5.0	-4.9	-4.6	4.3	-4.1	-0.4	1.8
Times rat made contact with spout	0.2	0.2	1.1	-0.2	-0.1	0.0	-0.4	-0.5	-1.0	0.1
Lifetime Intake	0.1	0.1	0.4	0.7	0.0	0.5	-0.0	0.2	0.6	0.0
Liver weight, left	0.4	0.7	1.4	-1.2	-0.8	-0.3	0.5	-0.8	-1.0	0.8
Liver weight, right	1.5	2.5	5.6	-2.3	-1.7	-2.4	1.5	-1.3	-0.2	0.1
Locomotor activity	0.4	0.6	1.8	-0.3	-0.1	-1.2	-0.6	0.0	-0.5	-1.3
Locomotor testing distance	0.1	0.2	0.6	-0.4	-0.3	-0.6	-0.3	-0.4	-0.8	-0.6
Locomotor testing rearing	0.0	0.1	0.2	-0.3	-0.1	-0.3	-0.2	-0.4	0.1	-0.2
Locomotion in novel chamber	1.4	1.7	3.1	1.0	1.8	0.9	-1.2	1.6	-0.9	-1.5
Locomotion in novel chamber post-restriction	0.8	0.9	3.2	0.2	0.9	-0.6	-0.9	1.0	-0.5	-1.8
Fecal boli incidents, locomotor time 1	0.3	0.4	1.2	-0.2	0.1	-1.1	-0.4	0.3	-0.2	-1.0
Change in fecal boli incidents, locomotor task	0.8	0.8	2.2	-0.5	-0.8	1.0	0.5	-1.1	-0.4	1.5
Time >=10cm from walls, locomotor time 1	0.6	0.6	3.0	0.1	-0.4	-0.6	0.7	-0.3	1.7	0.5
Bouts of movement, locomotor time 1	0.2	0.2	0.5	-0.7	-0.4	-0.4	0.5	-0.2	-0.7	-0.3
Total resting periods, locomotor time 1	0.2	0.2	0.4	-0.7	-0.4	-0.6	0.6	-0.2	-0.5	-0.3
Rest time, locomotor task time 1	0.9	0.9	2.3	-0.9	-1.2	-1.5	0.8	-1.1	0.1	0.3
Distance moved, locomotor task time 1	1.0	1.0	1.7	1.1	1.3	1.0	-1.2	1.2	0.0	-0.8
Vertical activity count, locomotor time 1	0.7	0.7	1.4	0.5	1.0	0.6	-0.7	1.2	-0.4	-1.0
Time >=10cm from walls, locomotor time 2	2.7	2.9	4.7	-1.7	-2.0	-2.2	1.5	-1.7	1.4	1.2
Bouts of movement, locomotor time 2	0.6	0.6	2.7	-0.6	-0.6	-1.6	0.2	-0.2	0.4	-0.7
Total resting periods, locomotor time 2	0.6	0.7	2.5	-0.9	-0.8	-1.6	0.5	-0.5	0.3	-0.4
Rest time, locomotor task time 2	0.3	0.3	0.7	0.2	-0.1	-0.9	-0.7	-0.1	0.8	-0.3
Distance moved, locomotor task time 2	0.6	0.7	2.6	0.0	0.4	1.4	-0.1	0.0	-1.6	0.3
Vertical activity count, locomotor time 2	0.7	0.7	4.1	-0.8	0.1	0.6	0.1	0.1	-2.0	-0.3
Light reinforcement 1	0.6	1.1	1.9	1.1	1.2	0.6	-1.2	1.4	1.0	-0.7
Light reinforcement 2	0.6	0.7	2.2	0.6	0.9	1.5	-0.8	0.8	-0.7	-0.3
Bone: marrow area	0.2	0.4	1.2	-0.9	-0.3	-0.4	0.4	-0.4	-1.1	-0.5
Bone: maximum diameter	1.1	2.1	3.7	-1.8	-1.7	-1.9	1.6	-1.4	0.1	0.2
Bone: maximum force	1.0	1.8	3.4	-1.8	-1.5	-1.7	1.4	-1.3	-0.6	0.1
Bone: maximum moment	0.8	1.3	2.7	-1.7	-1.3	-1.4	1.1	-1.1	-0.7	0.0
Mean time between licks in bursts	0.8	1.1	1.6	1.3	1.2	0.9	-1.2	1.1	0.5	-0.9
Mean num. licks in bursts	0.8	0.9	3.2	0.3	-0.5	-1.7	-0.1	-0.2	1.8	-0.2
Cd content in liver	5.8	6.4	11.2	2.7	3.2	2.0	-3.3	2.9	-0.5	-1.8
Co content in liver	0.6	0.7	2.2	0.4	0.8	1.1	-0.5	0.3	-1.5	0.1
Cu content in liver	0.6	0.7	1.4	0.6	0.9	-0.3	-0.8	1.2	0.6	-1.0
Fe content in liver	1.7	2.1	8.6	-0.7	-0.8	-2.9	0.5	0.1	1.7	-1.2
K content in liver	0.3	0.3	0.6	-0.5	-0.2	-0.7	0.7	-0.0	0.8	-0.1
Mg content in liver	0.1	0.1	0.6	-0.8	-0.2	-0.2	0.5	-0.2	-0.3	0.1
Mn content in liver	0.4	0.5	1.8	0.3	0.3	1.4	-0.0	-0.1	-1.0	0.7
Na content in liver	0.4	0.4	0.8	-0.7	-0.7	-0.9	0.3	-0.6	0.4	0.3
Rb content in liver	0.9	1.2	3.2	1.3	1.0	-0.1	-0.4	1.3	1.8	-0.6
Se content in liver	3.4	4.2	10.1	-1.8	-1.9	-3.2	2.2	-1.1	2.6	0.3
Sr content in liver	1.0	0.9	2.7	-0.4	-0.7	0.9	0.3	-1.0	-1.7	1.1
Zn content in liver	1.6	1.8	3.3	-1.8	-1.4	-0.6	1.5	-1.3	-1.2	1.2
Bone: minimum diameter	0.0	0.0	0.1	-0.2	0.0	0.2	0.4	-0.1	-0.3	-0.2
Time in familiar zone, hab. session 1	0.9	0.8	2.3	-0.5	-0.9	0.3	0.8	-1.2	-0.3	1.5
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.3	0.0	-0.0	-0.4
Total zone transitions, hab. session 1	1.8	2.5	4.5	2.0	1.9	0.8	-1.4	2.1	0.9	-1.4
Total locomotion distance, hab. session 1	0.7	1.0	2.7	1.1	0.7	-0.4	-0.5	1.3	1.7	-0.8
Locomotion velocity, hab. session 1	1.5	2.1	3.6	1.8	1.4	0.1	-1.3	1.9	1.8	-1.2
Time in familiar zone, hab. session 2	0.7	0.7	1.2	-0.8	-1.0	-0.4	1.1	-1.0	0.3	1.1
Time in novel zone, hab. session 2	0.8	0.8	1.5	0.9	1.0	0.5	-1.2	1.0	0.1	-1.1
Total zone transitions, hab. session 2	0.4	0.5	1.3	0.2	0.6	1.0	-0.7	0.4	-1.1	-0.3
Total locomotion distance, hab. session 2	0.4	0.5	0.7	0.7	0.8	0.7	-0.8	0.8	-0.1	-0.6
Locomotion velocity, hab. session 2	0.4	0.6	0.9	0.8	0.9	0.9	-0.9	0.9	-0.3	-0.5
Novel to familiar place preference ratio	0.3	0.3	0.8	0.3	0.2	0.9	-0.3	-0.2	-0.9	0.6
Novelty place preference	0.4	0.4	1.0	0.6	0.4	1.0	-0.6	0.0	-0.8	0.5
Time in novel zone, NPP test	0.2	0.3	0.6	0.3	0.1	0.8	-0.4	-0.2	-0.7	0.6
Total zone transitions, NPP test	0.2	0.3	0.8	0.3	0.6	0.1	-0.8	0.7	-0.0	-0.9
Total locomotion distance, NPP test	0.7	0.9	2.5	0.5	0.2	-1.1	-0.6	0.8	1.6	-1.1
Locomotion velocity, NPP test	1.0	1.4	3.0	0.9	0.8	-0.8	-1.1	1.3	1.3	-1.7
Intraocular pressure	0.7	1.0	3.5	-0.9	-0.7	-1.9	0.9	-0.3	0.5	-0.8
Delta distance traveled before/after self-admin	0.2	0.2	0.9	-0.3	-0.0	0.5	0.2	0.0	-0.9	0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.1	0.1	0.5	0.0	0.2	-0.4	0.1
Parametrial fat weight	0.6	1.2	2.0	-0.9	-1.0	0.8	0.8	-1.2	-1.4	1.4
Pavlov. Cond. lever latency	1.0	1.3	2.2	-1.4	-1.4	-0.6	0.6	-1.5	-1.4	0.5
Pavlov. Cond. magazine entry latency	0.0	0.1	0.2	-0.4	0.0	-0.4	-0.0	0.0	0.0	-0.2
Pavlov. Cond. change in total contacts	0.3	0.3	1.3	-0.1	0.0	-0.3	0.7	0.2	1.2	0.2
Pavlov. Cond. index score	0.2	0.2	1.0	0.0	0.3	-0.6	0.1	0.5	1.0	-0.2
Pavlov. Cond. latency score	0.3	0.3	1.4	0.2	0.4	-0.4	-0.0	0.6	1.2	-0.3
Pavlov. Cond. lever contacts	0.9	1.0	2.0	1.2	1.1	0.3	-0.6	1.3	1.4	-0.6
Pavlov. Cond. magazine entry number	0.3	0.4	1.1	0.2	-0.2	1.0	0.3	-0.5	-0.6	1.0
Pavlov. Cond. intertrial magazine entries	1.8	2.1	3.5	1.8	1.7	1.4	-1.9	1.5	-0.1	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.9	-0.1	0.1	-0.6	0.1	0.3	1.0	0.0
Pavlov. Cond. response bias	0.3	0.3	0.9	0.0	0.3	-0.8	-0.1	0.6	0.9	-0.6
Pavlov. Cond. lever latency	0.7	1.0	2.0	-0.8	-0.6	0.9	0.4	-1.0	-1.4	1.3
Pavlov. Cond. magazine entry latency	0.8	1.0	3.0	1.2	0.7	-0.3	-0.5	1.0	1.7	-0.7
Pavlov. Cond. change in total contacts	0.8	1.1	2.0	1.1	1.0	-0.3	-1.0	1.3	0.8	-1.4
Pavlov. Cond. index score	1.4	1.8	2.7	1.5	1.2	-0.5	-0.9	1.6	1.6	-1.6
Pavlov. Cond. latency score	1.2	1.4	2.7	1.3	1.0	-0.5	-0.7	1.4	1.7	-1.4
Pavlov. Cond. lever contacts	0.9	1.2	3.9	0.6	0.3	-1.4	-0.2	0.9	2.0	-1.2
Pavlov. Cond. magazine entry number	1.4	1.7	2.9	-1.7	-1.4	-0.2	0.9	-1.6	-1.4	1.2
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.9	-0.6	-0.0	-0.1	-0.1	-0.2	-0.9	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.9	1.6	1.4	-0.3	-1.1	1.7	1.5	-1.6
Pavlov. Cond. response bias	1.7	2.3	5.5	1.4	1.0	-1.2	-0.7	1.6	2.3	-1.8
Time in closed arm before self-admin	0.3	0.3	1.8	-0.3	-0.3	0.2	-0.3	-0.3	-1.3	-0.1
Time in closed arm after self-admin	1.3	1.3	2.7	0.6	1.4	0.3	-1.0	1.5	-0.9	-1.6
Time in open arm before self-admin	0.0	0.0	0.1	0.1	0.2	-0.1	0.1	0.2	-0.2	-0.3
Time in open arm after self-admin	0.6	0.7	1.4	-0.6	-1.1	-0.6	0.6	-1.2	0.7	0.8
Bone: periosteal estimation	0.8	1.6	3.2	-1.8	-1.4	-1.7	1.4	-1.2	-0.4	-0.1
Bone: periosteal perimeter	0.8	1.4	5.3	-0.7	-0.6	-2.3	0.5	-0.1	1.3	-1.1
Bone: post-yield work	0.5	0.7	2.1	-0.7	-0.2	-1.4	0.8	0.2	0.9	-0.7
Progressive ratio test 1 active lever presses	0.1	0.2	0.7	-0.2	-0.1	0.4	0.3	-0.0	-0.9	0.0
Progressive ratio test 1 breakpoint	0.3	0.3	1.0	-0.3	-0.3	0.5	0.5	-0.2	-1.0	0.3
Progressive ratio test 1 inactive lever presses	0.6	0.7	1.9	0.2	1.0	0.7	-0.5	0.9	-1.4	-0.7
Progressive ratio test 2 active lever presses	0.5	0.5	1.4	0.5	0.6	0.2	-0.5	0.9	-0.6	-1.2
Progressive ratio test 2 breakpoint	0.9	1.0	1.7	0.9	1.1	0.7	-0.8	1.3	-0.7	-1.3
Progressive ratio test 2 inactive lever presses	0.8	1.0	2.8	0.4	0.8	0.1	-0.8	0.9	-1.3	-1.7
Incentive Sensitization - Responses	1.2	1.2	2.3	1.1	1.3	0.5	-1.1	1.5	0.2	-1.3
Incentive Sensitization - Breakpoint	1.4	1.4	2.8	1.2	1.4	0.5	-1.2	1.7	0.3	-1.5
Sum of active levers in priming session hrs 5-6	1.1	1.1	2.1	-0.4	-1.3	-1.0	1.2	-0.7	1.5	0.8
Progressive ratio	0.5	0.5	1.8	0.7	0.7	1.3	-0.7	0.3	-0.5	0.2
Food seeking constrained by brief footshock	0.3	0.3	0.9	0.7	0.7	1.0	-0.3	0.5	-0.1	0.2
Seeking ratio, punishment vs. effort	0.3	0.4	0.9	-0.8	-0.6	-1.0	0.8	-0.3	0.1	0.2
Retroperitoneal fat weight	0.8	2.7	10.4	-0.4	-1.4	-1.9	0.8	-0.9	3.2	1.0
Reaction time number correct	0.2	0.3	0.8	0.2	0.5	0.1	-0.3	0.5	-0.9	-0.8
Reaction time mean minus median	1.3	1.7	4.6	0.2	-0.0	-2.2	-0.7	0.4	2.2	-1.3
Reaction time mean minus median AUC	1.7	2.2	3.4	1.4	1.3	-0.7	-1.8	1.5	1.5	-1.8
Reaction time num false alarms	0.9	1.3	3.1	0.9	1.0	-0.6	-1.0	1.1	1.2	-1.7
Reaction time num false alarms AUC	1.1	1.5	3.4	0.8	0.8	-1.1	-0.9	1.1	1.5	-1.9
Reaction time trials correct on left	0.2	0.3	0.8	0.2	0.5	0.1	-0.3	0.5	-0.9	-0.8
Reaction time trials on left	0.2	0.3	0.7	0.2	0.5	0.1	-0.3	0.5	-0.8	-0.8
Reaction time mean	0.6	0.8	1.7	1.2	0.7	0.6	-1.1	0.6	1.3	-0.0
Reaction time mean AUC	0.7	0.9	2.1	1.3	0.8	0.5	-1.2	0.7	1.5	-0.2
Median of all reaction times	0.8	1.1	2.1	1.4	0.9	1.4	-1.1	0.6	1.0	0.4
Reaction time omissions	1.0	1.3	3.4	1.2	0.9	-0.2	-1.9	0.8	1.4	-0.9
Reaction time false alarm rate	0.8	1.1	3.3	0.6	0.5	-1.1	-0.7	0.7	1.8	-1.3
Reaction time premature initiation rate	0.1	0.1	0.3	0.2	0.5	-0.0	-0.4	0.6	0.3	-0.3
Reaction time premature initiations	0.2	0.2	0.6	0.3	0.7	0.0	-0.5	0.8	-0.0	-0.5
Std. dev. reaction times	0.6	0.9	3.3	0.7	0.3	-0.9	-0.7	0.5	1.8	-0.8
Reaction time trials completed	0.2	0.3	0.7	0.2	0.5	0.1	-0.3	0.5	-0.8	-0.8
Reaction time trials AUC	0.3	0.4	1.1	0.5	0.7	0.1	-0.5	0.8	-0.6	-1.0
Run reversals in cocaine runway, females	0.1	0.1	0.3	0.4	0.3	0.1	-0.2	0.5	0.5	-0.2
Run reversals in cocaine runway, males	2.3	2.2	4.2	1.5	1.7	1.1	-2.0	1.5	-0.8	-1.5
Latency to leave start box in cocaine runway	0.3	0.3	0.6	-0.0	-0.6	0.5	0.3	-0.7	-0.4	0.8
Latency to leave start box in cocaine runway, F	1.5	1.7	2.7	-0.8	-1.6	0.4	1.4	-1.6	-1.1	1.6
Latency to leave start box in cocaine runway, M	3.1	2.9	4.8	1.7	1.9	0.3	-2.0	2.0	1.0	-2.2
Std. dev. time between licks in bursts	0.8	0.9	3.3	0.5	0.8	-0.5	-1.0	1.0	0.5	-1.8
Total sessions with >9 infusions	0.0	0.0	0.1	0.1	-0.3	-0.2	-0.3	-0.2	0.2	-0.0
Short access day 1 total inactive lever presses	0.3	0.3	1.0	0.1	0.3	0.9	-0.3	-0.1	-1.0	0.2
Short access day 10 total inactive lever presses	1.1	1.2	2.1	-1.4	-1.1	-0.7	1.2	-1.3	-1.2	0.5
Short access day 1 total infusions	0.4	0.4	1.3	0.3	-0.6	0.9	0.2	-0.7	0.2	1.2
Short access day 10 total infusions	0.3	0.3	0.8	0.7	0.3	0.3	-0.3	0.5	0.9	-0.1
Short access total infusions	0.7	0.8	2.1	-0.2	-1.0	0.6	0.9	-1.1	0.1	1.4
Short access day 1 locomotion	1.1	1.2	2.2	1.5	1.2	0.8	-1.2	1.2	0.8	-0.7
Short access day 10 total locomotion	0.7	0.8	2.6	0.9	0.7	-0.0	-1.6	0.6	0.9	-0.7
Short access total locomotion	0.5	0.5	1.5	0.8	0.4	0.1	-0.9	0.4	1.2	-0.1
One hour access (0.3 mA shock)	2.7	3.2	4.8	1.8	2.2	1.5	-2.0	2.1	-0.9	-1.7
Compulsive drug intake	2.9	2.9	4.8	1.7	2.1	2.2	-2.1	1.8	0.0	-0.4
One hour access (shock baseline)	0.4	0.5	1.8	0.4	0.5	-0.7	-0.3	0.8	-0.1	-1.3
Social response proportion	1.0	1.1	2.8	-1.7	-0.9	-0.8	1.1	-0.7	-1.2	0.7
Social responses	0.4	0.5	1.5	-0.6	-0.0	-1.2	0.1	0.4	-0.0	-1.2
Social time	1.9	2.5	4.7	2.2	2.0	1.7	-1.7	1.7	0.3	-0.6
Soleus weight	0.9	2.5	7.0	-1.9	-1.5	-2.6	1.7	-0.9	0.7	-0.8
Bone: stiffness	0.2	0.2	1.0	-0.5	-0.2	-1.0	0.3	0.0	0.1	-0.6
Tibialis anterior weight	3.8	12.9	25.8	-4.6	-4.2	-5.1	3.9	-3.2	0.4	0.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.2	0.1	0.6	-0.3	0.2	0.4	0.5
Time to tail flick, vehicle, after self-admin	0.5	0.5	1.2	0.6	0.9	0.5	-0.5	1.1	0.4	-0.6
Time to tail flick, test, before self-admin	0.6	0.6	1.0	-1.0	-1.0	-0.2	0.8	-0.9	-0.8	0.5
Time to tail flick, test, after self-admin	1.0	1.1	2.6	-1.0	-1.3	-0.4	1.6	-1.0	0.3	1.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.9	0.7	0.9	0.3	-0.3	0.9	0.4	-0.7
Delta time to tail flick, test, before/after SA	0.2	0.2	1.0	-0.0	-0.3	-0.5	0.2	-0.1	1.0	0.3
Tibia length	3.4	9.5	14.7	-3.8	-3.3	-1.0	3.3	-3.5	-2.9	3.0
Ambulatory time before self-admin	1.5	1.5	2.8	0.9	1.0	-0.8	-1.0	1.3	1.7	-1.6
Ambulatory time after self-admin	0.4	0.4	0.8	0.3	0.3	-0.6	-0.4	0.6	0.9	-0.9
Bone: tissue strength	0.2	0.2	0.7	-0.4	-0.2	0.5	0.2	-0.4	-0.8	0.2
Total heroin consumption	2.7	3.1	6.5	2.0	1.7	-0.2	-1.3	2.1	2.6	-1.5
Bone: trabecular number	4.5	7.1	10.8	-3.2	-3.3	-3.1	3.0	-2.8	0.0	1.2
Bone: trabecular spacing	3.3	4.2	7.0	2.6	2.5	2.2	-2.3	2.2	0.5	-0.9
Bone: trabecular thickness	4.9	5.9	12.9	-2.8	-2.9	-3.6	2.5	-2.2	0.9	0.5
Bone: trabecular tissue density	0.4	0.5	1.8	0.4	0.1	-0.9	-0.5	0.5	1.3	-0.7
Water consumed over 24 hours	0.6	0.7	3.9	-0.7	-0.3	0.2	-0.3	-0.7	-2.0	0.3
Number of responses in last shaping day	0.1	0.1	0.2	0.3	0.3	0.3	-0.4	0.1	-0.4	-0.2