Hub : Genes

Lrrc8e

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Lrrc8e 0.44 0.15 4.0e-08 0.03 0.06 0.07 0.06 1.6e-04 4.8e-07 9.0e-08 3.3e-07
2 NAcc gene expression Lrrc8e 0.37 0.13 7.9e-15 0.07 0.1 0.1 0.1 1.2e-10 2.7e-15 1.0e-14 2.3e-15
3 Brain gene expression Lrrc8e 0.24 0.12 8.8e-06 0.05 0.06 0.07 0.08 1.3e-05 1.2e-06 9.1e-07 4.6e-08
4 Liver gene expression Lrrc8e 0.83 0.06 0.0e+00 0.2 0.24 0.27 0.27 2.9e-21 2.2e-26 2.6e-30 4.0e-30
5 Adipose gene expression Lrrc8e 0.13 0.08 3.3e-10 0.06 0.06 0.08 0.06 5.6e-07 2.3e-07 2.8e-09 3.1e-07
6 IC gene expression Lrrc8e 0.26 0.15 2.3e-03 0.1 0.07 0.07 0.1 5.1e-05 7.1e-04 4.6e-04 5.2e-05
7 BLA gene expression Lrrc8e 0.57 0.14 2.1e-03 0 0 0.02 0.03 2.8e-01 2.6e-01 2.2e-02 6.9e-03
8 Liver alternative TSS XM_063271247.1 0.42 0.14 1.9e-10 0.04 0.07 0.07 0.07 5.8e-05 4.2e-08 5.0e-08 5.1e-08
9 Adipose alternative TSS XM_006248764.5 0.03 0.02 1.2e-03 0 0 0 0 7.9e-02 7.3e-02 3.4e-01 1.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density3.05.213.6-3.7-3.1-3.1-1.70.8-2.0-2.40.70.7
Area under the delay curve0.30.31.00.80.50.90.5-0.00.30.1-0.41.0
BMI with tail2.58.617.0-4.1-3.9-3.8-2.62.0-3.2-2.41.70.9
BMI without tail3.29.722.6-4.8-4.4-4.3-2.90.5-2.8-2.81.90.1
Body weight8.336.384.8-9.2-8.6-8.2-5.9-0.4-4.3-5.83.5-0.6
Weight adjusted by age0.60.91.8-1.3-1.1-1.1-0.9-1.3-0.4-0.70.9-0.6
Bone surface3.87.017.5-4.2-3.7-3.6-2.30.6-2.4-2.41.10.6
Bone volume3.25.713.6-3.7-3.1-3.0-1.81.5-2.3-2.30.71.3
Breakpoint value in progressive ratio session0.60.73.8-0.3-0.10.00.31.90.4-0.7-0.61.1
Number of licking bursts1.62.710.90.2-0.2-0.7-1.0-2.60.01.61.5-3.3
Context. condit. distance diff. score2.73.26.7-2.6-1.8-2.2-0.21.8-1.3-2.6-0.51.6
Locomotion velocity, session 10.20.20.40.50.50.70.40.40.3-0.2-0.30.5
Locomotion distance, session 10.81.02.51.41.61.31.50.10.50.2-0.70.3
Locomotion velocity, session 20.20.30.91.00.60.40.2-0.30.30.60.2-0.7
Locomotion distance, session 22.43.37.02.62.42.22.3-1.32.00.1-1.3-0.3
Locomotion velocity, session 30.50.62.4-0.8-0.2-0.40.31.6-0.0-0.8-0.51.0
Locomotion distance, session 30.20.30.9-0.10.50.21.00.60.2-0.3-0.70.3
Stereotopy head waving bouts, day 31.21.42.8-1.4-1.7-1.4-1.2-1.60.1-1.10.7-0.5
Stereotopy head waving duration, day 30.20.30.90.2-0.5-0.1-0.8-1.00.2-0.10.7-0.1
Locomotion velocity, session 70.10.10.50.70.50.40.20.0-0.30.10.00.2
Locomotion distance, session 70.20.31.10.50.60.31.00.1-0.1-0.2-0.70.5
Stereotopy head waving bouts, day 70.50.61.50.90.91.10.40.31.20.5-0.60.3
Stereotopy head waving duration, day 70.60.71.51.21.21.20.30.41.00.8-0.30.1
Locomotion velocity, session 80.20.31.1-0.6-0.5-0.7-0.3-0.4-1.0-0.20.4-0.2
Locomotion distance, session 80.71.02.2-1.3-1.0-1.50.00.3-1.2-1.5-0.10.5
Degree of sensitization distance0.30.31.01.00.60.50.2-0.4-0.40.80.2-0.2
Degree of sensitization stereotypy0.50.61.30.70.91.00.41.10.70.7-0.60.6
Conditioned locomotion0.40.41.2-0.0-0.10.20.21.10.5-1.0-0.51.0
Cocaine response after cond. corrected2.32.76.7-1.5-2.0-1.5-2.6-0.2-2.0-0.12.3-0.3
Cocaine response after cond. not corrected2.02.34.3-1.7-1.8-1.5-2.00.9-2.1-0.81.50.8
Cocaine response before conditioning2.02.45.9-0.10.70.41.82.00.3-1.7-2.12.4
Saline control response1.01.35.70.30.50.31.0-1.52.4-0.0-1.0-1.2
Bone: connectivity density3.65.715.0-3.9-3.4-3.4-2.00.3-1.7-2.30.90.2
Bone: cortical apparent density0.30.41.1-0.3-0.5-0.4-1.00.1-1.00.50.90.1
Bone: cortical area1.31.94.6-2.1-1.9-1.7-1.00.8-1.0-1.70.20.8
Bone: cortical porosity0.20.20.60.60.80.30.4-0.40.5-0.0-0.2-0.4
Bone: cortical porosity0.80.91.91.11.41.01.10.11.1-0.1-0.90.3
Bone: cortical thickness1.01.63.4-1.8-1.8-1.8-1.20.5-1.0-1.30.50.3
Bone: cortical thickness0.10.20.5-0.5-0.4-0.5-0.30.00.5-0.7-0.2-0.0
Bone: cortical tissue density0.20.30.9-0.2-0.4-0.3-0.9-0.0-0.90.50.9-0.0
Condit. Reinf. active minus inactive responses0.30.31.60.10.10.4-0.31.3-0.30.2-0.20.9
Condit. Reinf. active-inactive response ratio0.60.61.9-0.7-0.7-0.3-0.81.4-1.0-0.20.21.0
Condit. Reinf. active responses0.81.01.70.81.01.21.01.20.9-0.1-1.31.1
Condit. Reinf. inactive responses2.63.25.91.92.32.22.40.12.2-0.1-2.00.7
Incentive salience index mean0.91.12.20.80.91.10.91.50.8-0.1-1.31.4
Condit. Reinf. lever presses1.42.03.41.21.41.51.51.11.5-0.4-1.81.6
Condit. Reinf. active minus inactive responses0.10.20.4-0.7-0.5-0.6-0.20.30.1-0.3-0.3-0.3
Condit. Reinf. active-inactive response ratio0.10.10.50.30.20.30.3-0.20.70.1-0.3-0.6
Condit. Reinf. active responses0.40.61.7-0.9-0.5-0.60.11.30.1-0.8-0.90.7
Condit. Reinf. inactive responses0.50.62.0-0.7-0.3-0.40.21.4-0.0-0.6-0.91.2
Condit. Reinf. lever presses0.81.14.0-0.7-0.2-0.10.52.00.1-1.0-1.11.6
Condit. Reinf. lever reinforcers received0.30.51.9-0.5-0.2-0.30.41.40.2-0.5-1.00.7
Conditioned reinforcement - actives0.61.02.1-1.1-1.2-1.3-0.9-0.70.3-1.50.4-0.9
Conditioned reinforcement - inactives0.30.41.70.3-0.20.1-0.7-0.80.90.50.3-1.3
Conditioned locomotion0.50.61.6-1.0-0.5-0.50.10.41.0-1.2-1.10.5
Patch foraging indifference point 0 sec0.00.10.1-0.2-0.0-0.30.20.3-0.4-0.1-0.40.1
Patch foraging indifference point AUC0.40.62.1-0.7-0.8-1.0-0.4-1.4-0.5-0.00.2-1.0
Delay disc. indifference point, 0s delay2.12.44.5-1.8-1.9-1.6-2.1-0.5-2.0-0.31.80.0
Delay disc. indifference point, 16s delay0.30.41.30.90.40.60.4-1.10.50.2-0.40.4
Delay disc. indifference point, 2s delay1.21.35.20.30.50.90.42.3-0.4-0.2-0.62.3
Delay disc. indifference point, 24s delay0.60.72.11.40.91.00.3-1.10.60.8-0.2-0.2
Delay disc. indifference point, 4s delay0.70.73.00.30.30.70.41.4-0.0-0.3-0.61.7
Delay disc. indifference point, 8s delay0.70.91.91.01.01.11.40.20.9-0.1-1.10.8
Indifference point function ln k0.50.93.90.81.01.10.9-0.42.0-0.2-0.6-0.1
Indifference point function log k0.50.93.90.81.01.10.9-0.42.0-0.2-0.6-0.1
Patch foraging total patch changes 0 sec0.00.10.40.10.30.10.50.30.0-0.1-0.70.1
Patch foraging total patch changes 12 sec0.50.61.5-1.1-1.0-1.1-0.5-0.5-1.2-0.40.3-0.0
Patch foraging total patch changes 18 sec0.30.51.2-0.6-0.4-0.8-0.4-0.9-1.10.70.2-0.7
Patch foraging total patch changes 24 sec0.81.34.00.81.20.82.00.10.8-0.1-2.00.5
Patch foraging total patch changes 6 sec0.20.30.8-0.8-0.4-0.80.30.2-0.9-0.4-0.40.0
Patch foraging time to switch 0 sec1.32.69.3-1.2-1.3-0.9-1.91.1-3.10.32.10.6
Patch foraging water rate 0 sec0.71.46.20.30.70.21.4-0.32.5-0.6-1.7-0.7
Patch foraging water rate 12 sec1.32.68.31.41.61.52.00.22.9-0.5-2.10.3
Patch foraging water rate 18 sec3.25.012.22.12.42.62.70.73.5-0.4-2.70.9
Patch foraging water rate 24 sec0.91.35.10.10.80.51.60.62.2-0.9-1.5-0.2
Patch foraging water rate 6 sec1.62.35.80.81.21.11.91.22.4-0.9-2.21.1
Seeking ratio, delayed vs. immediate footshock1.21.46.11.60.90.90.0-0.50.02.50.5-1.3
Distance traveled before self-admin0.81.02.01.41.21.11.20.70.50.3-0.91.1
Distance traveled after self-admin0.81.02.51.31.10.81.4-0.00.8-0.1-1.60.8
Extensor digitorum longus weight1.97.620.9-4.6-3.8-3.7-1.40.7-1.0-3.9-0.41.0
Bone: elastic displacement0.10.10.2-0.4-0.5-0.3-0.3-0.50.2-0.5-0.0-0.4
Bone: elastic work1.41.85.2-2.3-1.8-2.0-0.8-0.1-0.7-1.60.0-0.2
Bone: endosteal estimation0.20.41.3-0.7-0.6-0.70.0-1.10.5-0.7-0.1-0.9
Bone: endosteal perimeter0.40.92.1-1.5-0.8-0.80.50.90.0-1.5-1.00.8
Epididymis fat weight0.20.82.5-0.5-0.3-0.10.11.6-0.1-1.1-0.81.6
Delta time in closed arm before/after self-admin0.10.10.30.0-0.1-0.1-0.20.20.20.5-0.3-0.1
Delta time in open arm before/after self-admin1.21.26.00.10.91.00.92.5-0.40.0-0.41.3
Diff in mean of infusions in LGA sessions0.20.21.10.10.10.10.40.00.7-1.0-0.40.5
Delay discount exponential model param0.70.81.7-1.1-0.9-1.2-0.8-0.4-0.5-0.10.8-1.3
Extinction: sum of active levers before priming0.50.52.20.20.10.20.41.5-0.1-0.5-0.41.3
Active lever presses in extinction session 60.40.42.0-0.4-0.1-0.50.31.4-0.3-0.6-0.30.5
Bone: final force0.81.32.9-1.4-1.4-1.7-1.0-1.0-0.3-0.80.8-1.1
Bone: final moment0.61.02.1-1.1-1.1-1.4-0.9-1.1-0.1-0.60.7-1.2
Food consumed during 24 hour testing period0.20.31.20.10.20.1-0.2-0.40.70.90.3-1.1
Glucose0.20.31.11.00.51.0-0.2-0.50.20.40.20.5
Heart weight0.40.61.80.30.80.51.1-0.70.9-0.3-1.3-0.3
Delay discount hyperbolic model param0.60.61.8-0.9-0.7-1.1-0.7-0.5-0.4-0.10.7-1.3
Intermittent access intake day 1-15 change0.61.22.8-0.8-1.3-1.0-1.4-1.3-0.1-0.11.0-1.7
Intermittent access intake escalation0.61.23.1-0.7-1.2-1.0-1.3-1.6-0.1-0.21.0-1.8
Intermittent access intake escalation 20.40.41.4-0.2-0.7-0.3-0.9-0.6-0.20.30.7-1.2
Intermitt. access day 1 inactive lever presses0.10.52.10.50.3-0.20.1-1.40.10.50.4-1.3
Intermitt. access day 15 inactive lever presses0.71.43.2-1.4-1.2-1.2-1.10.2-1.8-0.81.8-0.0
Intermitt. access escalation Index0.71.02.10.61.00.91.31.00.8-0.0-1.41.0
Intermittent access day 1 total infusions1.42.24.41.72.11.62.10.71.40.3-1.70.7
Intermittent access day 15 total infusions0.40.61.10.80.90.61.0-0.61.1-0.3-0.9-0.3
Intermittent access terminal intake (last 3 days)0.10.20.40.70.60.30.50.10.40.0-0.4-0.3
Intermittent access total infusions0.50.51.30.80.90.50.91.10.4-0.2-0.70.6
Intermittent access day 1 locomotion2.12.64.51.31.91.62.11.41.2-0.4-2.11.8
Intermittent access day 15 total locomotion1.52.86.71.11.61.72.00.42.6-0.5-2.60.9
Intermittent access total locomotion2.32.74.61.31.81.62.01.91.6-0.2-2.21.5
Intermittent access standard deviation0.61.32.9-0.8-1.2-1.2-1.4-0.6-1.3-0.11.7-1.2
Left kidney weight4.219.345.3-6.7-6.3-6.2-4.0-1.9-2.2-4.32.3-1.3
Right kidney weight3.817.239.4-6.3-5.8-5.8-4.1-2.0-2.4-3.52.6-1.5
Cocaine induced anxiety0.50.72.20.10.20.10.61.5-0.1-0.8-0.81.5
Post-drug Anxiety1.21.34.8-0.0-0.10.1-0.12.2-1.6-0.50.61.9
Baseline Anxiety0.80.94.10.2-0.2-0.0-0.8-0.2-1.50.92.0-0.3
Tail length4.316.639.3-6.3-5.6-5.7-3.6-2.5-2.1-4.02.2-1.5
Length with tail7.432.374.5-8.6-8.0-7.9-5.5-3.0-2.7-5.43.1-2.3
Length without tail5.617.937.0-6.1-6.0-5.9-4.4-1.9-2.5-3.72.8-1.7
Times rat made contact with spout0.30.30.8-0.8-0.3-0.5-0.4-0.80.30.20.3-0.9
Lifetime Intake0.40.51.20.80.90.50.81.10.2-0.1-0.40.6
Liver weight, left2.54.28.1-2.5-2.5-2.8-2.2-0.9-1.4-0.12.1-2.3
Liver weight, right1.11.94.7-2.2-1.9-2.0-1.30.2-0.7-1.20.8-0.2
Locomotor activity0.30.51.4-1.1-0.4-0.70.50.10.5-1.2-0.8-0.2
Locomotor testing distance0.20.31.2-1.1-0.6-0.8-0.2-0.2-0.2-0.50.0-0.6
Locomotor testing rearing0.20.41.4-1.1-0.5-0.5-0.51.2-0.7-0.10.30.2
Locomotion in novel chamber1.21.52.71.11.30.51.5-1.61.70.3-1.3-0.9
Locomotion in novel chamber post-restriction1.01.64.20.60.90.51.6-1.82.0-0.6-1.8-0.2
Fecal boli incidents, locomotor time 10.30.41.1-0.4-0.4-0.50.1-0.91.0-0.7-0.7-0.1
Change in fecal boli incidents, locomotor task1.01.02.6-0.8-0.8-0.7-1.2-0.2-1.50.31.6-0.7
Time >=10cm from walls, locomotor time 10.60.62.8-0.3-0.10.2-0.11.3-0.8-0.4-0.11.7
Bouts of movement, locomotor time 10.50.51.8-0.9-0.8-0.7-0.3-1.30.4-0.8-0.1-0.5
Total resting periods, locomotor time 10.40.51.3-0.9-0.8-0.7-0.4-1.10.4-0.7-0.2-0.4
Rest time, locomotor task time 11.21.53.9-2.0-1.8-1.6-1.0-0.1-0.6-1.30.50.1
Distance moved, locomotor task time 10.81.22.81.71.61.31.30.10.81.0-0.70.1
Vertical activity count, locomotor time 10.30.81.81.41.00.71.1-0.70.90.6-0.9-0.3
Time >=10cm from walls, locomotor time 21.42.13.8-1.7-1.5-1.5-1.00.7-2.0-1.70.71.5
Bouts of movement, locomotor time 20.30.41.6-0.8-0.5-0.60.30.00.3-1.3-0.70.7
Total resting periods, locomotor time 20.30.51.7-1.1-0.9-0.8-0.10.0-0.0-1.3-0.30.5
Rest time, locomotor task time 20.40.52.1-0.9-0.50.1-0.21.50.1-0.6-0.30.9
Distance moved, locomotor task time 21.01.24.81.00.5-0.10.1-2.20.01.10.7-1.7
Vertical activity count, locomotor time 21.31.811.10.80.0-0.70.2-3.30.40.20.3-2.0
Light reinforcement 10.51.22.01.41.21.31.30.70.50.1-1.21.2
Light reinforcement 20.30.51.31.20.70.60.3-0.90.50.7-0.2-0.6
Bone: marrow area0.20.51.4-0.7-0.6-0.60.1-1.20.5-0.6-0.1-0.9
Bone: maximum diameter0.71.43.5-1.9-1.8-1.3-0.90.0-0.2-1.60.20.4
Bone: maximum force0.61.12.8-1.7-1.4-1.7-0.6-0.5-0.5-1.00.2-0.5
Bone: maximum moment0.40.82.0-1.4-1.1-1.4-0.5-0.6-0.3-0.80.2-0.6
Mean time between licks in bursts0.61.53.21.51.71.61.80.60.7-0.1-1.10.6
Mean num. licks in bursts0.60.93.6-0.6-0.10.20.41.40.1-1.1-0.91.9
Cd content in liver3.64.08.32.32.32.32.6-0.62.90.5-2.20.0
Co content in liver1.31.54.11.01.20.80.5-1.61.21.5-0.1-2.0
Cu content in liver0.50.51.10.90.70.80.9-0.41.0-0.3-0.90.2
Fe content in liver2.22.76.9-0.70.00.41.52.61.2-1.8-2.12.4
K content in liver0.20.20.70.0-0.00.0-0.00.6-0.0-0.5-0.20.8
Mg content in liver0.20.20.80.20.1-0.1-0.1-0.90.40.20.1-0.5
Mn content in liver0.40.51.60.50.50.2-0.2-0.6-0.01.10.7-1.2
Na content in liver0.50.61.4-1.1-1.2-1.0-0.9-0.2-0.4-0.40.5-0.2
Rb content in liver2.52.94.71.92.22.01.91.90.60.6-1.61.8
Se content in liver3.54.27.8-2.3-1.8-1.7-0.82.5-2.0-2.8-0.22.8
Sr content in liver1.31.12.7-0.3-0.8-0.7-1.1-1.7-0.50.41.3-1.6
Zn content in liver0.60.71.5-0.5-0.8-1.1-0.8-1.20.5-0.60.3-1.0
Bone: minimum diameter0.00.10.4-0.3-0.2-0.20.1-0.1-0.60.20.1-0.3
Time in familiar zone, hab. session 10.90.92.0-0.7-0.9-0.6-1.4-0.5-1.3-0.01.4-0.5
Time in novel zone, hab. session 10.10.10.20.0-0.3-0.2-0.0-0.40.5-0.3-0.20.1
Total zone transitions, hab. session 11.72.34.62.21.91.91.80.71.30.5-1.60.8
Total locomotion distance, hab. session 11.11.53.51.21.01.11.21.90.50.1-1.41.7
Locomotion velocity, hab. session 11.92.74.91.81.71.71.82.20.80.4-1.81.8
Time in familiar zone, hab. session 20.60.61.6-0.5-0.7-0.8-1.10.2-1.3-0.21.00.2
Time in novel zone, hab. session 20.60.61.10.70.81.01.1-0.11.0-0.0-0.90.2
Total zone transitions, hab. session 20.30.42.00.40.3-0.10.3-1.4-0.00.40.1-1.2
Total locomotion distance, hab. session 20.30.40.90.90.90.80.80.10.60.4-0.6-0.0
Locomotion velocity, hab. session 20.40.51.11.01.00.80.8-0.10.70.6-0.6-0.2
Novel to familiar place preference ratio0.20.20.9-0.30.0-0.0-0.2-0.2-0.20.90.5-0.9
Novelty place preference0.20.31.30.00.30.3-0.00.0-0.01.10.4-0.8
Time in novel zone, NPP test0.20.20.9-0.3-0.0-0.0-0.2-0.1-0.31.00.6-0.8
Total zone transitions, NPP test0.20.31.10.70.60.31.0-0.60.4-0.4-0.70.0
Total locomotion distance, NPP test0.81.22.90.30.50.51.31.20.3-1.2-1.41.7
Locomotion velocity, NPP test1.21.73.60.91.01.01.81.01.2-1.1-1.91.5
Intraocular pressure0.50.72.1-1.0-0.4-0.60.50.50.7-1.4-1.00.8
Delta distance traveled before/after self-admin0.20.21.0-0.1-0.2-0.3-0.2-0.7-0.00.1-0.1-1.0
Delta ambulatory time before/after self-admin0.10.10.50.20.20.10.0-0.5-0.10.5-0.1-0.7
Parametrial fat weight0.82.03.7-1.6-1.9-1.3-1.5-0.8-1.6-1.21.60.4
Pavlov. Cond. lever latency1.92.44.2-1.8-2.0-1.8-1.8-1.5-0.9-0.11.5-1.5
Pavlov. Cond. magazine entry latency0.20.20.8-0.6-0.3-0.20.4-0.10.4-0.9-0.50.2
Pavlov. Cond. change in total contacts0.40.41.10.00.30.10.51.0-0.7-0.8-0.41.1
Pavlov. Cond. index score0.40.61.00.40.60.50.90.80.5-0.8-0.91.0
Pavlov. Cond. latency score0.60.71.30.60.80.71.01.00.5-0.7-1.01.2
Pavlov. Cond. lever contacts1.51.72.91.41.71.41.61.60.40.1-1.31.4
Pavlov. Cond. magazine entry number0.50.61.70.1-0.1-0.2-1.0-0.2-0.91.31.1-0.8
Pavlov. Cond. intertrial magazine entries1.41.74.41.82.11.51.70.00.80.7-1.0-0.1
Pavlov. Cond. lever-magazine prob. diff.0.30.41.00.30.40.30.80.80.2-0.9-0.71.0
Pavlov. Cond. response bias0.50.71.40.00.40.41.10.80.7-1.0-1.20.9
Pavlov. Cond. lever latency0.91.23.9-0.3-0.7-0.9-1.0-2.0-0.80.41.4-1.5
Pavlov. Cond. magazine entry latency1.41.64.70.91.21.51.02.20.80.1-1.11.6
Pavlov. Cond. change in total contacts1.01.72.51.01.21.41.51.51.60.2-1.60.8
Pavlov. Cond. index score1.82.44.11.31.61.81.62.01.50.2-1.81.5
Pavlov. Cond. latency score1.62.14.01.11.41.61.42.01.30.1-1.71.6
Pavlov. Cond. lever contacts1.21.75.40.30.81.01.22.30.8-0.4-1.61.8
Pavlov. Cond. magazine entry number1.82.33.8-1.5-1.7-1.8-1.5-2.0-1.3-0.71.5-1.2
Pavlov. Cond. intertrial magazine entries0.20.30.6-0.6-0.3-0.80.0-0.8-0.2-0.10.1-0.8
Pavlov. Cond. lever-magazine prob. diff.2.02.74.11.51.71.91.72.01.70.3-1.91.4
Pavlov. Cond. response bias2.43.38.11.01.61.71.92.81.3-0.3-2.22.2
Time in closed arm before self-admin1.41.711.00.60.1-0.30.3-3.31.1-0.40.1-1.7
Time in closed arm after self-admin1.21.34.51.00.60.20.7-2.11.60.4-0.8-1.5
Time in open arm before self-admin0.10.10.50.20.10.30.10.10.30.4-0.70.4
Time in open arm after self-admin0.91.05.5-0.7-0.10.10.02.3-1.0-0.40.21.4
Bone: periosteal estimation0.51.13.0-1.7-1.5-1.5-0.6-0.4-0.3-1.40.1-0.2
Bone: periosteal perimeter0.71.33.2-1.2-0.7-0.40.61.30.3-1.8-1.31.5
Bone: post-yield work0.30.51.3-0.5-0.2-0.30.51.20.1-0.6-0.91.1
Progressive ratio test 1 active lever presses0.20.20.5-0.2-0.3-0.7-0.1-0.70.1-0.60.1-0.6
Progressive ratio test 1 breakpoint0.20.20.5-0.2-0.3-0.7-0.2-0.70.0-0.60.2-0.6
Progressive ratio test 1 inactive lever presses0.50.72.40.70.60.10.4-1.51.00.0-0.2-1.3
Progressive ratio test 2 active lever presses0.40.41.40.30.2-0.10.2-1.20.8-0.3-0.3-1.1
Progressive ratio test 2 breakpoint0.40.41.20.40.3-0.00.3-1.10.9-0.2-0.4-1.1
Progressive ratio test 2 inactive lever presses0.40.61.3-0.8-0.1-0.60.2-1.20.8-0.9-0.4-1.1
Incentive Sensitization - Responses0.10.10.30.50.30.20.0-0.10.20.3-0.1-0.6
Incentive Sensitization - Breakpoint0.10.10.40.60.40.30.2-0.00.30.3-0.2-0.5
Sum of active levers in priming session hrs 5-61.11.01.9-1.1-1.0-1.1-0.51.0-1.4-1.10.60.8
Progressive ratio0.50.81.91.31.00.80.2-0.80.41.40.5-1.0
Food seeking constrained by brief footshock0.30.41.50.80.50.7-0.10.60.31.20.3-0.3
Seeking ratio, punishment vs. effort0.30.51.2-1.1-1.1-0.7-0.70.6-0.2-0.7-0.00.2
Retroperitoneal fat weight0.62.75.0-1.5-1.6-1.2-1.31.8-2.2-1.60.72.2
Reaction time number correct0.30.61.90.60.40.30.7-1.21.40.1-0.6-0.8
Reaction time mean minus median0.71.85.4-1.00.10.11.02.1-0.2-1.4-1.52.3
Reaction time mean minus median AUC0.71.83.60.41.31.31.91.50.9-0.4-1.91.6
Reaction time num false alarms0.60.82.10.10.90.61.41.10.2-0.4-1.41.0
Reaction time num false alarms AUC0.61.02.5-0.30.60.31.31.3-0.0-0.7-1.61.3
Reaction time trials correct on left0.30.61.90.60.40.30.7-1.21.40.1-0.6-0.8
Reaction time trials on left0.30.61.90.60.40.30.7-1.21.40.1-0.6-0.8
Reaction time mean0.40.61.50.60.91.10.60.9-0.60.3-0.31.2
Reaction time mean AUC0.50.81.90.71.01.20.81.3-0.40.3-0.51.4
Median of all reaction times0.40.61.51.11.01.20.30.5-0.60.80.30.6
Reaction time omissions0.50.71.90.20.81.01.01.10.4-0.3-0.81.4
Reaction time false alarm rate0.81.13.4-0.50.40.20.91.9-0.5-0.8-1.31.7
Reaction time premature initiation rate0.20.20.50.40.40.30.60.70.1-0.1-0.70.6
Reaction time premature initiations0.20.30.80.60.60.40.90.40.70.1-0.80.2
Std. dev. reaction times0.61.03.7-0.40.40.51.01.5-0.5-0.8-1.01.9
Reaction time trials completed0.30.61.90.60.40.30.7-1.21.40.1-0.6-0.8
Reaction time trials AUC0.40.72.10.70.70.51.0-1.01.40.1-0.8-0.6
Run reversals in cocaine runway, females0.10.10.50.40.20.40.30.4-0.2-0.1-0.30.7
Run reversals in cocaine runway, males1.91.93.91.71.71.41.6-0.82.00.5-1.2-0.7
Latency to leave start box in cocaine runway0.40.41.2-0.4-0.6-0.5-1.0-0.5-0.8-0.01.1-0.4
Latency to leave start box in cocaine runway, F1.82.14.4-1.0-1.6-1.4-2.0-1.0-1.4-0.02.1-1.3
Latency to leave start box in cocaine runway, M0.60.61.40.61.00.91.20.10.5-0.3-0.90.7
Std. dev. time between licks in bursts0.71.02.70.60.80.71.70.31.2-1.0-1.40.6
Total sessions with >9 infusions0.10.20.50.60.4-0.1-0.1-0.3-0.50.20.7-0.2
Short access day 1 total inactive lever presses0.20.31.0-0.5-0.3-0.6-0.7-0.0-0.4-0.31.0-0.5
Short access day 10 total inactive lever presses1.74.26.8-2.6-2.4-2.4-2.1-1.3-2.0-1.12.4-1.4
Short access day 1 total infusions0.10.20.50.60.50.20.10.1-0.70.10.70.2
Short access day 10 total infusions0.60.73.70.40.60.20.71.9-0.2-0.5-0.41.2
Short access total infusions0.30.41.10.40.3-0.1-0.11.0-1.00.10.80.5
Short access day 1 locomotion0.70.81.60.81.30.81.11.10.50.1-0.90.9
Short access day 10 total locomotion0.00.10.2-0.00.40.20.40.50.20.1-0.20.1
Short access total locomotion0.40.51.40.60.90.60.71.2-0.00.2-0.41.0
One hour access (0.3 mA shock)1.11.34.60.71.00.80.9-1.12.10.2-1.1-1.2
Compulsive drug intake1.51.73.92.01.31.80.6-1.51.31.5-0.6-0.1
One hour access (shock baseline)0.30.51.1-0.50.2-0.20.70.61.0-0.9-1.1-0.1
Social response proportion1.01.12.6-1.2-1.3-1.6-1.1-1.1-0.0-0.30.6-1.2
Social responses0.30.41.2-0.9-0.4-0.50.50.50.5-0.9-1.10.2
Social time1.52.14.42.12.02.11.20.31.21.7-0.7-0.0
Soleus weight0.61.75.1-1.8-1.6-1.2-0.20.80.4-2.3-0.91.1
Bone: stiffness0.10.20.5-0.10.1-0.10.7-0.00.7-0.5-0.70.1
Tibialis anterior weight2.99.825.5-5.1-4.2-4.5-2.00.7-1.9-4.00.50.7
Time to tail flick, vehicle, before self-admin0.20.20.91.00.00.1-0.30.3-0.60.60.60.4
Time to tail flick, vehicle, after self-admin0.10.10.40.60.50.20.30.40.10.2-0.50.0
Time to tail flick, test, before self-admin1.81.99.2-0.7-1.0-1.2-1.1-3.0-0.5-0.21.0-1.5
Time to tail flick, test, after self-admin0.10.10.50.2-0.2-0.1-0.3-0.5-0.70.10.60.1
Delta time to tail flick, vehicle, before/after SA0.40.40.90.30.70.60.80.30.7-0.2-0.90.3
Delta time to tail flick, test, before/after SA0.80.84.00.50.60.80.62.00.00.1-0.41.1
Tibia length3.49.416.5-3.4-3.9-4.1-3.7-2.6-2.1-0.43.0-2.8
Ambulatory time before self-admin0.91.32.70.91.00.91.41.30.7-0.5-1.41.7
Ambulatory time after self-admin0.70.82.00.80.80.71.30.60.4-0.3-1.41.1
Bone: tissue strength0.70.71.2-0.8-0.8-0.8-0.7-1.1-1.10.10.8-0.8
Total heroin consumption3.64.315.51.41.91.82.03.90.70.2-2.02.3
Bone: trabecular number2.94.811.7-3.4-2.9-3.1-1.80.4-2.1-2.01.00.4
Bone: trabecular spacing2.53.37.62.82.62.51.80.71.21.6-1.10.4
Bone: trabecular thickness2.73.37.9-2.8-2.4-2.3-1.10.8-0.9-2.70.01.2
Bone: trabecular tissue density0.30.41.4-0.10.20.10.70.7-0.1-1.0-0.81.2
Water consumed over 24 hours1.11.54.7-0.9-0.9-1.1-1.1-1.70.50.81.0-2.2
Number of responses in last shaping day0.10.10.30.30.30.40.50.40.1-0.00.10.3