Hub : Genes

Lrrc46

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Lrrc46 0.05 0.03 2.4e-05 0.04 0.04 0.04 0.04 4.0e-05 1.7e-05 3.1e-05 1.8e-05
2 pVTA gene expression Lrrc46 0.08 0.05 1.7e-03 0.05 0.07 0.05 0.05 3.4e-03 6.3e-04 3.6e-03 2.6e-03
3 BLA mRNA stability Lrrc46 0.06 0.05 8.9e-03 0.03 0.02 0.02 0.02 7.1e-03 2.2e-02 4.7e-02 3.6e-02
4 PL gene expression Lrrc46 0.06 0.03 2.9e-09 0.08 0.08 0.07 0.08 4.9e-09 2.3e-09 3.0e-08 3.1e-09
5 NAcc gene expression Lrrc46 0.03 0.02 2.1e-04 0.02 0.02 0.02 0.02 4.8e-03 1.8e-03 2.6e-03 3.9e-03
6 pVTA mRNA stability Lrrc46 0.15 0.13 2.7e-03 0.04 0.03 0.03 0.03 1.2e-02 1.7e-02 1.4e-02 2.3e-02
7 BLA gene expression Lrrc46 0.11 0.1 9.6e-04 0.04 0.03 0.02 0.02 5.5e-03 6.3e-03 2.7e-02 3.5e-02
8 Brain gene expression Lrrc46 0.06 0.04 7.7e-06 0.06 0.05 0.05 0.06 1.2e-06 2.9e-05 2.4e-05 7.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.52.54.12.01.0-1.51.51.7-1.7-1.4-1.8
Area under the delay curve0.30.30.70.0-0.80.4-0.6-0.70.40.60.6
BMI with tail11.336.545.54.46.7-6.36.35.8-6.1-6.4-6.0
BMI without tail1.32.63.31.21.8-1.71.61.4-1.8-1.7-1.6
Body weight0.52.27.7-1.12.8-1.51.00.1-1.2-1.4-1.3
Weight adjusted by age0.80.91.1-1.0-0.80.9-1.0-1.01.10.71.1
Bone surface0.30.50.90.40.8-0.60.60.5-0.9-0.5-0.9
Bone volume1.01.82.51.21.3-1.31.31.2-1.5-1.2-1.6
Breakpoint value in progressive ratio session4.95.46.0-2.5-2.02.4-2.4-2.42.32.32.3
Number of licking bursts0.10.10.20.1-0.50.4-0.2-0.10.30.30.2
Context. condit. distance diff. score0.20.30.50.10.7-0.40.50.4-0.7-0.5-0.6
Locomotion velocity, session 10.50.61.20.21.1-0.70.80.7-0.7-0.8-0.7
Locomotion distance, session 12.63.46.1-2.5-1.01.5-1.8-2.11.91.71.9
Locomotion velocity, session 20.91.01.7-1.3-0.60.9-1.1-1.30.90.90.9
Locomotion distance, session 23.04.25.4-2.3-1.61.8-2.1-2.32.12.02.2
Locomotion velocity, session 30.00.10.1-0.3-0.10.1-0.2-0.40.30.10.2
Locomotion distance, session 33.23.54.3-2.0-1.51.8-1.9-2.11.91.81.8
Stereotopy head waving bouts, day 34.55.48.62.91.5-2.12.32.5-2.3-2.2-2.4
Stereotopy head waving duration, day 33.13.74.52.11.6-1.91.92.0-1.9-2.0-2.0
Locomotion velocity, session 71.61.82.2-1.4-1.11.2-1.4-1.51.31.21.5
Locomotion distance, session 75.06.37.2-2.3-2.52.5-2.7-2.72.42.52.5
Stereotopy head waving bouts, day 70.60.61.11.10.5-0.70.91.0-0.7-0.8-0.7
Stereotopy head waving duration, day 70.20.20.50.60.4-0.50.60.7-0.3-0.5-0.4
Locomotion velocity, session 80.30.41.3-1.11.2-0.30.2-0.1-0.3-0.3-0.2
Locomotion distance, session 80.71.02.4-1.5-0.30.8-1.0-1.20.80.91.0
Degree of sensitization distance0.00.00.1-0.2-0.00.1-0.1-0.20.10.10.2
Degree of sensitization stereotypy0.10.10.40.3-0.60.3-0.10.10.40.20.4
Conditioned locomotion1.01.21.61.11.0-1.01.11.0-1.3-1.0-1.2
Cocaine response after cond. corrected6.06.78.22.82.1-2.62.52.5-2.9-2.4-2.7
Cocaine response after cond. not corrected3.53.96.22.51.3-1.91.81.9-2.2-1.8-2.0
Cocaine response before conditioning2.32.84.3-0.9-2.11.7-1.7-1.61.81.71.7
Saline control response0.30.40.7-0.1-0.80.7-0.5-0.40.60.60.8
Bone: connectivity density0.20.31.31.2-0.3-0.20.40.7-0.5-0.2-0.6
Bone: cortical apparent density5.97.713.1-1.4-3.63.1-2.8-2.22.93.02.8
Bone: cortical area0.00.00.10.30.1-0.20.10.1-0.2-0.0-0.3
Bone: cortical porosity0.50.61.21.10.4-0.80.70.8-0.7-0.7-0.6
Bone: cortical porosity0.40.51.31.10.3-0.80.60.7-0.6-0.7-0.5
Bone: cortical thickness0.30.41.00.0-1.00.6-0.7-0.60.60.80.5
Bone: cortical thickness1.21.43.50.1-1.91.2-1.2-1.01.01.41.0
Bone: cortical tissue density6.28.113.6-1.5-3.73.1-2.8-2.32.93.12.8
Condit. Reinf. active minus inactive responses0.10.10.30.0-0.50.4-0.3-0.20.30.30.3
Condit. Reinf. active-inactive response ratio0.30.30.80.90.1-0.40.50.6-0.4-0.5-0.5
Condit. Reinf. active responses0.10.10.20.2-0.50.3-0.2-0.00.20.40.1
Condit. Reinf. inactive responses0.30.30.7-0.2-0.80.7-0.5-0.30.50.80.3
Incentive salience index mean0.20.30.80.1-0.90.5-0.5-0.30.60.50.5
Condit. Reinf. lever presses0.81.01.9-0.4-1.40.9-1.0-0.81.21.01.1
Condit. Reinf. active minus inactive responses0.20.20.70.80.1-0.60.40.5-0.4-0.5-0.1
Condit. Reinf. active-inactive response ratio0.50.50.80.80.6-0.90.80.9-0.6-0.7-0.4
Condit. Reinf. active responses0.10.10.50.7-0.3-0.10.10.2-0.1-0.10.1
Condit. Reinf. inactive responses0.30.41.30.4-1.10.6-0.5-0.30.60.50.5
Condit. Reinf. lever presses0.60.81.1-0.6-0.90.8-0.9-0.81.00.91.1
Condit. Reinf. lever reinforcers received0.10.10.30.5-0.60.1-0.10.00.20.20.4
Conditioned reinforcement - actives1.71.73.31.80.7-1.31.31.4-1.1-1.3-1.2
Conditioned reinforcement - inactives0.70.81.9-0.0-1.40.9-0.8-0.51.00.91.1
Conditioned locomotion4.95.98.12.81.9-2.62.52.5-2.2-2.5-2.3
Patch foraging indifference point 0 sec1.01.73.31.80.8-1.21.21.3-1.2-1.3-1.3
Patch foraging indifference point AUC0.20.20.5-0.7-0.20.4-0.4-0.30.40.40.6
Delay disc. indifference point, 0s delay1.11.32.1-0.4-1.51.0-1.2-1.01.21.11.3
Delay disc. indifference point, 16s delay0.30.30.70.80.3-0.60.40.4-0.7-0.4-0.7
Delay disc. indifference point, 2s delay0.40.41.10.3-1.10.4-0.7-0.70.70.30.8
Delay disc. indifference point, 24s delay0.30.30.5-0.5-0.50.6-0.6-0.60.40.70.3
Delay disc. indifference point, 4s delay3.94.15.3-1.4-2.21.9-2.2-2.31.92.02.1
Delay disc. indifference point, 8s delay0.10.10.40.2-0.60.2-0.3-0.30.00.40.2
Indifference point function ln k0.00.00.10.30.1-0.20.10.1-0.3-0.1-0.3
Indifference point function log k0.00.00.10.30.1-0.20.10.1-0.3-0.1-0.3
Patch foraging total patch changes 0 sec1.01.62.71.60.9-1.21.21.2-1.2-1.3-1.3
Patch foraging total patch changes 12 sec0.40.52.31.5-0.2-0.40.60.8-0.6-0.5-0.5
Patch foraging total patch changes 18 sec1.41.82.21.41.3-1.51.51.5-1.2-1.4-1.1
Patch foraging total patch changes 24 sec1.41.72.81.70.9-1.31.31.4-1.2-1.4-1.2
Patch foraging total patch changes 6 sec1.01.52.51.60.9-1.21.31.4-1.2-1.2-1.1
Patch foraging time to switch 0 sec0.10.10.20.50.2-0.20.40.5-0.3-0.3-0.4
Patch foraging water rate 0 sec0.50.81.20.71.0-1.10.80.6-1.0-1.0-0.9
Patch foraging water rate 12 sec0.10.20.5-0.6-0.10.2-0.5-0.70.40.40.4
Patch foraging water rate 18 sec0.70.91.5-0.3-1.20.9-1.1-1.11.00.81.1
Patch foraging water rate 24 sec0.50.71.21.10.6-0.90.80.7-0.9-0.8-0.7
Patch foraging water rate 6 sec0.10.10.40.2-0.60.2-0.3-0.20.30.30.5
Seeking ratio, delayed vs. immediate footshock0.30.40.80.40.6-0.30.60.7-0.8-0.3-0.9
Distance traveled before self-admin0.50.61.1-0.6-0.70.6-0.8-0.80.80.61.0
Distance traveled after self-admin1.51.72.80.61.7-1.51.31.0-1.3-1.4-1.2
Extensor digitorum longus weight0.41.55.7-2.12.4-0.80.5-0.3-0.6-0.7-0.4
Bone: elastic displacement0.20.20.40.50.4-0.60.50.4-0.4-0.6-0.4
Bone: elastic work0.00.00.10.10.2-0.30.1-0.0-0.2-0.1-0.2
Bone: endosteal estimation0.40.82.1-0.21.4-0.90.70.4-1.0-0.8-1.0
Bone: endosteal perimeter0.51.02.3-0.01.5-0.90.90.6-1.1-1.0-1.0
Epididymis fat weight0.00.00.1-0.20.3-0.30.0-0.20.1-0.2-0.0
Delta time in closed arm before/after self-admin0.20.10.8-0.90.50.0-0.1-0.30.10.1-0.1
Delta time in open arm before/after self-admin0.20.20.5-0.3-0.50.6-0.4-0.40.40.20.7
Diff in mean of infusions in LGA sessions0.70.81.2-0.8-0.91.0-0.8-0.61.01.10.8
Delay discount exponential model param0.40.40.70.20.8-0.50.70.8-0.5-0.6-0.6
Extinction: sum of active levers before priming0.90.91.3-1.1-0.71.1-1.0-1.10.80.80.9
Active lever presses in extinction session 60.20.20.20.50.2-0.30.40.4-0.5-0.4-0.4
Bone: final force0.30.41.21.10.1-0.70.50.6-0.6-0.4-0.7
Bone: final moment0.30.51.31.10.2-0.80.60.6-0.7-0.5-0.7
Food consumed during 24 hour testing period1.31.62.8-1.7-0.81.3-1.2-1.31.21.31.2
Glucose0.40.71.31.10.5-0.90.70.6-0.9-0.8-0.7
Heart weight1.01.43.10.21.7-1.21.10.8-1.2-1.2-1.2
Delay discount hyperbolic model param0.70.71.20.31.1-0.71.01.0-0.7-0.8-0.9
Intermittent access intake day 1-15 change2.22.22.91.51.3-1.71.51.4-1.4-1.7-1.3
Intermittent access intake escalation2.42.33.01.51.4-1.71.51.5-1.4-1.7-1.3
Intermittent access intake escalation 21.61.62.30.91.4-1.51.31.1-1.1-1.4-1.1
Intermitt. access day 1 inactive lever presses0.40.51.1-0.0-1.10.6-0.6-0.40.70.80.8
Intermitt. access day 15 inactive lever presses0.30.41.21.1-0.2-0.20.61.0-0.4-0.2-0.5
Intermitt. access escalation Index2.72.43.50.91.9-1.51.61.4-1.8-1.4-1.7
Intermittent access day 1 total infusions0.20.20.4-0.1-0.60.5-0.4-0.30.40.60.3
Intermittent access day 15 total infusions0.30.30.70.80.3-0.60.60.6-0.5-0.5-0.5
Intermittent access terminal intake (last 3 days)0.20.20.50.70.3-0.50.50.6-0.4-0.4-0.4
Intermittent access total infusions0.00.00.10.30.0-0.10.10.2-0.1-0.0-0.1
Intermittent access day 1 locomotion0.20.20.40.1-0.60.4-0.4-0.20.40.50.4
Intermittent access day 15 total locomotion0.30.40.80.90.3-0.50.60.7-0.5-0.5-0.6
Intermittent access total locomotion0.70.91.71.30.6-0.90.91.0-0.9-0.8-0.9
Intermittent access standard deviation1.51.61.91.31.1-1.41.31.2-1.2-1.4-1.1
Left kidney weight0.20.62.3-1.50.60.2-0.5-1.10.10.3-0.1
Right kidney weight0.20.71.70.11.3-0.90.60.2-0.9-0.8-1.1
Cocaine induced anxiety0.10.10.5-0.60.7-0.30.2-0.0-0.1-0.1-0.0
Post-drug Anxiety0.60.60.9-0.8-0.70.8-0.7-0.60.91.00.9
Baseline Anxiety0.20.20.60.7-0.80.3-0.00.30.30.20.2
Tail length10.230.939.4-5.6-4.85.5-5.9-6.35.45.55.3
Length with tail7.126.038.4-6.2-3.54.8-5.4-6.14.94.94.6
Length without tail0.51.14.1-2.00.30.5-0.9-1.30.80.70.6
Times rat made contact with spout0.00.00.20.2-0.40.3-0.10.00.10.20.1
Lifetime Intake0.00.00.00.1-0.10.1-0.00.10.10.10.0
Liver weight, left0.91.41.5-1.2-1.11.2-1.2-1.21.11.21.2
Liver weight, right1.32.23.1-1.2-1.51.5-1.6-1.81.31.61.3
Locomotor activity0.61.01.61.30.7-0.71.11.3-0.9-0.8-1.0
Locomotor testing distance1.32.25.32.30.6-1.21.51.9-1.3-1.2-1.2
Locomotor testing rearing0.30.42.01.4-0.80.00.30.7-0.0-0.00.0
Locomotion in novel chamber0.81.02.3-0.1-1.51.1-1.0-0.80.91.10.9
Locomotion in novel chamber post-restriction1.92.32.81.61.3-1.61.61.7-1.5-1.6-1.3
Fecal boli incidents, locomotor time 12.42.73.41.11.8-1.51.71.6-1.8-1.7-1.7
Change in fecal boli incidents, locomotor task2.22.02.5-1.1-1.61.4-1.5-1.51.51.41.5
Time >=10cm from walls, locomotor time 10.20.20.50.1-0.70.6-0.3-0.00.20.50.2
Bouts of movement, locomotor time 10.10.10.2-0.10.30.00.20.1-0.4-0.1-0.5
Total resting periods, locomotor time 10.10.10.40.00.5-0.20.30.2-0.6-0.3-0.6
Rest time, locomotor task time 10.20.20.30.40.4-0.40.40.3-0.6-0.6-0.5
Distance moved, locomotor task time 10.91.01.5-0.7-1.21.1-1.1-1.01.01.11.0
Vertical activity count, locomotor time 10.10.10.2-0.3-0.40.4-0.4-0.30.40.30.4
Time >=10cm from walls, locomotor time 20.50.61.50.0-1.20.9-0.7-0.50.70.70.7
Bouts of movement, locomotor time 20.10.10.20.50.1-0.30.30.4-0.3-0.3-0.4
Total resting periods, locomotor time 20.10.10.20.40.2-0.40.40.4-0.3-0.3-0.4
Rest time, locomotor task time 21.11.32.0-1.4-0.81.3-1.0-1.01.11.31.1
Distance moved, locomotor task time 20.10.10.4-0.2-0.20.1-0.4-0.60.20.10.3
Vertical activity count, locomotor time 20.20.20.40.40.4-0.60.2-0.0-0.4-0.7-0.3
Light reinforcement 10.50.92.71.60.2-0.81.01.3-0.7-0.7-0.7
Light reinforcement 20.10.10.40.6-0.0-0.20.30.4-0.3-0.3-0.3
Bone: marrow area0.30.61.6-0.31.3-0.70.60.3-0.9-0.6-0.9
Bone: maximum diameter0.40.81.00.80.9-0.90.90.8-1.0-0.8-1.0
Bone: maximum force0.50.91.40.90.9-1.00.90.8-1.2-0.7-1.2
Bone: maximum moment0.61.01.50.91.0-1.10.90.7-1.2-0.8-1.2
Mean time between licks in bursts0.10.20.6-0.30.8-0.40.40.2-0.4-0.4-0.2
Mean num. licks in bursts0.00.00.1-0.1-0.30.2-0.2-0.20.20.20.2
Cd content in liver0.70.71.1-0.6-1.01.0-0.9-0.70.80.90.8
Co content in liver0.10.10.3-0.50.5-0.10.1-0.1-0.2-0.1-0.2
Cu content in liver1.92.23.3-1.8-1.11.6-1.4-1.41.51.61.4
Fe content in liver1.61.93.1-1.8-0.81.2-1.4-1.61.31.51.2
K content in liver0.10.10.20.40.2-0.30.30.3-0.3-0.4-0.4
Mg content in liver0.70.81.0-0.6-1.01.0-0.9-0.80.90.90.9
Mn content in liver2.22.53.3-1.1-1.81.8-1.5-1.31.71.71.7
Na content in liver0.80.91.11.00.8-0.91.01.1-0.8-1.0-0.8
Rb content in liver0.10.10.50.3-0.70.2-0.20.10.40.50.4
Se content in liver0.20.20.90.9-0.2-0.30.30.4-0.3-0.4-0.4
Sr content in liver1.71.62.1-1.3-1.11.3-1.4-1.41.31.01.3
Zn content in liver0.10.10.60.8-0.4-0.10.20.40.0-0.30.0
Bone: minimum diameter0.00.10.3-0.20.5-0.30.1-0.1-0.4-0.2-0.3
Time in familiar zone, hab. session 10.50.40.9-0.2-1.00.9-0.6-0.30.60.80.7
Time in novel zone, hab. session 13.02.93.41.91.5-1.81.71.7-1.7-1.8-1.7
Total zone transitions, hab. session 16.69.211.8-3.4-2.32.9-3.0-3.13.13.03.2
Total locomotion distance, hab. session 12.63.74.2-1.7-1.91.9-1.9-1.92.02.02.0
Locomotion velocity, hab. session 13.55.05.4-2.3-1.92.2-2.3-2.32.32.32.3
Time in familiar zone, hab. session 20.30.40.70.80.3-0.60.60.8-0.4-0.6-0.5
Time in novel zone, hab. session 20.00.00.1-0.1-0.20.2-0.3-0.30.10.20.1
Total zone transitions, hab. session 21.62.12.7-1.6-1.21.4-1.4-1.41.51.51.5
Total locomotion distance, hab. session 20.00.00.0-0.1-0.00.1-0.1-0.10.10.10.2
Locomotion velocity, hab. session 20.00.10.1-0.3-0.10.2-0.2-0.30.20.20.3
Novel to familiar place preference ratio1.01.02.1-1.4-0.51.0-1.0-1.20.71.00.7
Novelty place preference1.11.11.9-1.4-0.71.1-1.1-1.20.71.10.8
Time in novel zone, NPP test0.80.81.1-1.0-0.71.0-1.0-1.10.61.00.7
Total zone transitions, NPP test3.55.06.5-2.2-1.92.0-2.2-2.32.52.12.5
Total locomotion distance, NPP test0.91.21.9-0.8-1.00.9-1.1-1.11.30.91.4
Locomotion velocity, NPP test1.42.02.7-1.4-1.11.2-1.4-1.51.61.31.7
Intraocular pressure1.11.52.6-1.6-0.81.1-1.3-1.40.91.41.0
Delta distance traveled before/after self-admin3.13.34.91.12.2-1.91.91.7-1.9-1.8-1.9
Delta ambulatory time before/after self-admin3.13.54.41.42.1-1.91.91.8-1.9-1.8-1.9
Parametrial fat weight0.10.20.70.9-0.2-0.10.30.4-0.4-0.1-0.5
Pavlov. Cond. lever latency1.51.83.70.21.9-1.31.31.0-1.6-1.2-1.6
Pavlov. Cond. magazine entry latency0.40.52.81.7-1.10.10.10.5-0.00.00.0
Pavlov. Cond. change in total contacts2.02.25.3-0.0-2.31.6-1.4-0.91.51.61.4
Pavlov. Cond. index score0.70.93.00.9-1.70.7-0.6-0.20.80.70.9
Pavlov. Cond. latency score0.70.92.90.6-1.70.8-0.7-0.30.90.81.0
Pavlov. Cond. lever contacts1.82.13.9-0.4-2.01.4-1.4-1.11.61.41.7
Pavlov. Cond. magazine entry number0.60.72.6-1.51.6-0.50.2-0.3-0.4-0.4-0.5
Pavlov. Cond. intertrial magazine entries0.60.71.7-1.3-0.30.8-0.8-1.00.70.90.6
Pavlov. Cond. lever-magazine prob. diff.0.70.83.01.0-1.70.7-0.6-0.10.80.60.9
Pavlov. Cond. response bias0.70.93.21.0-1.80.7-0.6-0.10.80.70.9
Pavlov. Cond. lever latency0.50.71.0-1.0-0.70.9-0.9-0.90.80.90.7
Pavlov. Cond. magazine entry latency0.50.50.7-0.7-0.60.7-0.8-0.90.70.60.8
Pavlov. Cond. change in total contacts0.20.30.80.90.3-0.60.60.6-0.5-0.5-0.3
Pavlov. Cond. index score0.20.30.50.70.5-0.60.50.5-0.6-0.6-0.4
Pavlov. Cond. latency score0.10.10.20.50.3-0.40.30.2-0.3-0.4-0.2
Pavlov. Cond. lever contacts0.50.71.41.20.4-0.80.80.9-0.7-0.8-0.6
Pavlov. Cond. magazine entry number0.00.00.1-0.20.00.10.00.10.10.1-0.0
Pavlov. Cond. intertrial magazine entries1.82.43.9-2.0-1.11.5-1.5-1.51.51.61.5
Pavlov. Cond. lever-magazine prob. diff.0.30.40.50.70.6-0.70.60.5-0.6-0.7-0.5
Pavlov. Cond. response bias0.50.61.51.20.4-0.80.80.8-0.7-0.8-0.6
Time in closed arm before self-admin0.70.81.81.30.5-1.10.90.9-0.7-1.0-0.6
Time in closed arm after self-admin0.40.40.80.20.9-0.80.60.4-0.5-0.6-0.6
Time in open arm before self-admin0.10.20.9-0.90.40.2-0.1-0.20.20.2-0.1
Time in open arm after self-admin0.30.30.6-0.8-0.30.7-0.5-0.40.60.50.6
Bone: periosteal estimation0.30.71.10.51.0-0.90.80.6-1.0-0.7-1.0
Bone: periosteal perimeter0.30.51.00.11.0-0.70.60.4-0.8-0.7-0.8
Bone: post-yield work0.20.20.6-0.10.8-0.30.40.2-0.7-0.1-0.7
Progressive ratio test 1 active lever presses0.10.10.20.4-0.50.1-0.2-0.10.10.2-0.0
Progressive ratio test 1 breakpoint0.20.20.60.2-0.70.4-0.4-0.30.40.40.3
Progressive ratio test 1 inactive lever presses0.10.10.60.8-0.2-0.20.20.4-0.2-0.1-0.2
Progressive ratio test 2 active lever presses0.10.10.20.4-0.50.1-0.10.10.20.20.1
Progressive ratio test 2 breakpoint0.00.10.30.5-0.40.00.00.20.10.1-0.0
Progressive ratio test 2 inactive lever presses0.10.20.3-0.2-0.40.4-0.3-0.20.50.50.5
Incentive Sensitization - Responses0.10.10.40.6-0.2-0.10.20.3-0.1-0.1-0.1
Incentive Sensitization - Breakpoint0.20.20.60.80.1-0.40.40.5-0.3-0.3-0.3
Sum of active levers in priming session hrs 5-63.53.44.4-1.3-2.12.0-1.9-1.72.11.81.8
Progressive ratio0.50.51.0-0.6-0.70.6-0.7-0.71.00.50.9
Food seeking constrained by brief footshock0.70.91.31.00.7-0.90.90.9-1.1-0.7-1.1
Seeking ratio, punishment vs. effort0.70.81.70.90.7-0.70.90.9-1.3-0.4-1.2
Retroperitoneal fat weight0.31.11.80.91.1-1.30.90.6-1.1-1.2-1.1
Reaction time number correct0.20.40.7-0.9-0.20.3-0.5-0.60.60.50.8
Reaction time mean minus median0.20.20.5-0.4-0.40.6-0.3-0.20.50.70.2
Reaction time mean minus median AUC0.30.30.7-0.2-0.80.8-0.4-0.20.60.80.4
Reaction time num false alarms0.20.30.70.1-0.80.4-0.5-0.40.60.30.7
Reaction time num false alarms AUC0.30.40.8-0.1-0.90.5-0.6-0.50.70.40.8
Reaction time trials correct on left0.20.40.7-0.9-0.20.3-0.5-0.60.60.50.8
Reaction time trials on left0.20.30.7-0.9-0.20.3-0.5-0.60.60.50.8
Reaction time mean0.20.20.50.30.4-0.10.50.7-0.5-0.1-0.7
Reaction time mean AUC0.10.20.50.20.3-0.10.50.6-0.5-0.1-0.7
Median of all reaction times0.50.61.10.80.6-0.60.91.1-0.8-0.6-1.0
Reaction time omissions0.10.10.30.5-0.20.10.20.3-0.30.1-0.3
Reaction time false alarm rate0.10.10.30.5-0.60.1-0.10.00.2-0.00.2
Reaction time premature initiation rate0.20.30.6-0.2-0.80.6-0.6-0.60.60.50.5
Reaction time premature initiations0.60.81.0-0.8-0.80.8-0.9-1.01.00.81.0
Std. dev. reaction times0.00.10.2-0.2-0.20.4-0.10.00.20.5-0.0
Reaction time trials completed0.20.30.7-0.9-0.20.3-0.5-0.60.60.50.8
Reaction time trials AUC0.30.40.7-0.8-0.30.4-0.5-0.60.60.50.8
Run reversals in cocaine runway, females0.20.20.7-0.80.20.2-0.3-0.60.20.30.2
Run reversals in cocaine runway, males0.90.91.61.10.6-0.91.01.2-0.7-1.0-0.6
Latency to leave start box in cocaine runway2.22.34.60.52.1-1.71.61.3-1.4-1.5-1.6
Latency to leave start box in cocaine runway, F3.74.06.91.02.6-2.32.11.7-2.0-2.0-1.9
Latency to leave start box in cocaine runway, M0.50.51.00.20.8-0.50.70.7-0.7-0.5-1.0
Std. dev. time between licks in bursts1.21.41.90.81.4-1.21.21.2-1.2-1.3-1.1
Total sessions with >9 infusions0.60.61.31.10.4-0.70.70.8-0.8-0.8-0.8
Short access day 1 total inactive lever presses3.84.36.8-1.1-2.62.2-2.0-1.62.22.32.2
Short access day 10 total inactive lever presses1.01.11.4-1.2-0.91.1-1.0-0.91.11.21.1
Short access day 1 total infusions0.00.00.10.1-0.20.1-0.00.10.20.20.1
Short access day 10 total infusions0.30.40.40.70.5-0.60.60.6-0.6-0.6-0.6
Short access total infusions0.00.00.00.10.1-0.10.10.1-0.0-0.1-0.1
Short access day 1 locomotion0.80.82.11.40.4-0.90.91.0-0.8-0.9-0.7
Short access day 10 total locomotion0.40.51.61.30.2-0.70.60.7-0.5-0.6-0.5
Short access total locomotion0.70.71.41.20.6-0.90.80.8-0.7-0.9-0.7
One hour access (0.3 mA shock)0.50.60.9-0.5-0.90.9-0.8-0.60.80.80.8
Compulsive drug intake6.86.97.9-2.3-2.62.8-2.7-2.62.62.72.5
One hour access (shock baseline)2.32.73.11.81.4-1.71.71.7-1.6-1.7-1.6
Social response proportion0.60.71.0-0.6-0.90.8-1.0-1.00.70.80.8
Social responses0.00.00.10.1-0.30.2-0.2-0.1-0.10.20.0
Social time0.00.00.10.00.00.20.10.30.00.1-0.1
Soleus weight1.02.84.12.01.3-1.91.61.6-1.6-1.7-1.6
Bone: stiffness0.10.10.30.30.2-0.30.20.2-0.40.1-0.6
Tibialis anterior weight0.31.03.0-1.7-0.10.8-0.9-1.20.80.91.0
Time to tail flick, vehicle, before self-admin2.22.24.0-1.2-1.62.0-1.4-1.21.31.91.2
Time to tail flick, vehicle, after self-admin0.10.10.20.30.2-0.50.30.4-0.3-0.3-0.2
Time to tail flick, test, before self-admin0.00.00.1-0.30.20.10.10.0-0.20.2-0.0
Time to tail flick, test, after self-admin0.10.10.30.20.4-0.30.30.3-0.5-0.1-0.6
Delta time to tail flick, vehicle, before/after SA1.51.52.51.31.0-1.61.21.1-1.1-1.4-0.9
Delta time to tail flick, test, before/after SA0.10.10.30.2-0.60.1-0.3-0.30.20.20.2
Tibia length0.30.92.20.11.5-1.20.90.5-1.1-0.8-1.1
Ambulatory time before self-admin0.30.30.8-0.6-0.40.3-0.6-0.70.60.30.9
Ambulatory time after self-admin2.12.34.40.62.1-1.81.51.1-1.5-1.6-1.4
Bone: tissue strength0.20.20.4-0.00.6-0.40.40.3-0.5-0.4-0.5
Total heroin consumption1.61.92.6-1.1-1.51.6-1.3-1.11.41.61.3
Bone: trabecular number0.81.34.02.00.1-0.91.01.3-1.0-0.8-1.1
Bone: trabecular spacing0.10.10.2-0.50.20.0-0.1-0.10.3-0.10.4
Bone: trabecular thickness1.51.72.41.11.3-1.41.21.1-1.5-1.3-1.6
Bone: trabecular tissue density0.10.20.3-0.3-0.40.3-0.4-0.40.50.30.6
Water consumed over 24 hours0.20.20.3-0.4-0.50.5-0.4-0.40.50.60.5
Number of responses in last shaping day0.00.00.1-0.10.2-0.10.20.2-0.2-0.0-0.2