Hub : Genes

Lrrc45

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Lrrc45 0.05 0.03 9.0e-05 0.04 0.04 0.04 0.04 2.2e-05 3.6e-05 4.4e-05 3.1e-05
2 Liver intron excision ratio chr10_106492949_106493168 0.02 0.01 6.2e-03 0.01 0.01 0.01 0.01 9.9e-03 1.0e-02 2.8e-02 2.3e-02
3 Adipose gene expression Lrrc45 0.51 0.15 0.0e+00 0.38 0.4 0.38 0.39 3.5e-44 7.3e-47 8.9e-44 5.4e-46
4 BLA gene expression Lrrc45 0.14 0.09 3.7e-06 0.09 0.1 0.1 0.1 1.4e-05 9.8e-06 9.7e-06 9.4e-06
5 LHb gene expression Lrrc45 0.43 0.21 1.5e-04 0.08 0.08 0.02 0.07 5.8e-03 6.2e-03 9.5e-02 7.8e-03
6 pVTA gene expression Lrrc45 0.15 0.08 2.0e-12 0.16 0.16 0.15 0.16 1.2e-12 1.7e-12 2.7e-12 1.8e-12
7 Brain gene expression Lrrc45 0.2 0.1 7.8e-16 0.16 0.17 0.17 0.17 6.1e-15 3.0e-15 5.9e-16 1.8e-15
8 NAcc gene expression Lrrc45 0.25 0.13 0.0e+00 0.23 0.22 0.22 0.23 9.6e-34 4.4e-33 2.4e-33 3.2e-34
9 Liver gene expression Lrrc45 0.48 0.13 0.0e+00 0.5 0.53 0.53 0.53 3.2e-64 5.3e-69 1.1e-69 7.8e-69
10 IL gene expression Lrrc45 0.3 0.2 6.3e-04 0.13 0.13 0.21 0.1 6.3e-04 6.3e-04 9.8e-06 2.5e-03
11 PL gene expression Lrrc45 0.46 0.22 3.5e-13 0.12 0.12 0.12 0.13 9.4e-13 2.1e-13 3.0e-13 7.3e-14
12 Liver mRNA stability Lrrc45 0.45 0.14 0.0e+00 0.32 0.32 0.34 0.32 2.4e-36 1.3e-36 6.2e-39 7.7e-37

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.00.00.00.10.1-0.0-0.00.0-0.0-0.0-0.10.00.2-0.0-0.1
Area under the delay curve0.91.32.0-1.4-1.4-1.3-0.90.81.41.1-1.01.20.6-1.3-1.1
BMI with tail0.30.97.80.80.80.70.3-0.2-0.5-0.30.7-0.32.80.2-0.3
BMI without tail0.31.31.91.41.41.21.1-1.0-1.4-1.31.2-1.20.51.20.8
Body weight1.46.28.32.82.82.82.7-2.6-2.9-2.72.8-2.51.02.01.6
Weight adjusted by age0.72.23.51.11.11.51.7-1.8-1.6-1.61.9-1.5-0.31.61.5
Bone surface0.20.42.30.50.50.40.5-0.4-0.4-0.60.4-0.4-1.50.60.5
Bone volume0.10.20.90.50.50.40.4-0.3-0.3-0.50.3-0.4-0.90.50.3
Breakpoint value in progressive ratio session1.73.13.61.91.91.81.8-1.8-1.8-1.81.9-1.8-1.31.61.5
Number of licking bursts0.00.10.2-0.3-0.3-0.3-0.40.40.40.4-0.40.40.2-0.4-0.4
Context. condit. distance diff. score0.70.91.2-1.1-1.1-1.0-1.11.11.01.0-1.00.80.4-0.7-0.5
Locomotion velocity, session 10.00.00.00.00.0-0.1-0.20.20.00.10.10.1-0.10.20.1
Locomotion distance, session 13.64.65.9-2.1-2.1-2.1-2.12.12.12.1-2.12.12.4-2.3-2.0
Locomotion velocity, session 21.61.92.2-1.4-1.4-1.5-1.51.51.41.5-1.31.50.6-1.5-1.3
Locomotion distance, session 21.52.15.2-1.4-1.4-1.4-1.31.21.41.3-1.41.32.3-1.5-1.1
Locomotion velocity, session 30.20.20.6-0.3-0.3-0.3-0.50.50.40.5-0.50.50.1-0.8-0.7
Locomotion distance, session 31.71.93.0-1.3-1.3-1.2-1.51.51.21.4-1.41.41.1-1.7-1.5
Stereotopy head waving bouts, day 30.00.00.1-0.0-0.00.00.0-0.00.0-0.00.00.10.4-0.1-0.3
Stereotopy head waving duration, day 30.10.20.3-0.3-0.3-0.3-0.40.50.40.4-0.30.40.6-0.3-0.5
Locomotion velocity, session 70.60.61.0-0.8-0.8-0.7-0.80.80.70.8-0.90.8-0.5-1.0-0.8
Locomotion distance, session 74.86.17.6-2.5-2.5-2.5-2.72.82.62.6-2.62.51.4-2.5-2.1
Stereotopy head waving bouts, day 70.20.20.30.40.40.50.3-0.2-0.6-0.40.6-0.40.20.50.2
Stereotopy head waving duration, day 70.20.20.30.50.50.60.4-0.3-0.6-0.50.6-0.4-0.00.50.1
Locomotion velocity, session 82.32.74.9-1.6-1.6-1.7-1.61.51.71.6-1.61.52.2-1.7-1.3
Locomotion distance, session 83.04.46.5-2.2-2.2-2.1-2.12.12.12.0-2.21.92.6-2.0-1.6
Degree of sensitization distance0.10.10.2-0.4-0.4-0.4-0.30.30.50.2-0.30.2-0.40.20.2
Degree of sensitization stereotypy0.10.10.20.20.20.30.1-0.1-0.4-0.20.4-0.30.50.30.1
Conditioned locomotion0.40.50.80.70.70.50.8-0.8-0.5-0.70.6-0.80.10.90.7
Cocaine response after cond. corrected0.20.30.40.60.60.50.5-0.5-0.6-0.50.5-0.5-0.60.30.2
Cocaine response after cond. not corrected0.00.00.30.10.1-0.00.0-0.0-0.10.1-0.10.1-0.5-0.4-0.2
Cocaine response before conditioning1.31.62.7-1.3-1.3-1.2-1.21.21.31.2-1.51.30.4-1.7-1.3
Saline control response0.71.01.21.11.10.91.1-1.1-1.0-1.10.8-1.0-0.90.90.8
Bone: connectivity density0.40.60.9-0.9-0.9-0.9-0.80.80.90.8-0.90.80.1-0.6-0.6
Bone: cortical apparent density0.91.51.9-1.1-1.1-1.2-1.31.41.21.3-1.21.30.6-1.3-1.3
Bone: cortical area3.96.38.72.72.72.92.8-2.8-2.7-2.72.6-2.51.91.81.6
Bone: cortical porosity4.44.86.02.32.32.42.4-2.4-2.4-2.32.3-2.1-1.41.81.7
Bone: cortical porosity4.54.96.42.32.32.52.5-2.5-2.4-2.42.4-2.2-1.42.01.8
Bone: cortical thickness5.18.511.53.13.13.43.1-3.1-3.2-3.13.1-2.82.72.01.7
Bone: cortical thickness1.51.82.51.51.51.51.4-1.4-1.4-1.31.4-1.21.60.80.7
Bone: cortical tissue density0.91.52.0-1.2-1.2-1.2-1.41.41.21.3-1.21.30.4-1.2-1.3
Condit. Reinf. active minus inactive responses0.80.91.00.90.90.91.0-1.0-1.0-1.01.0-1.00.61.01.0
Condit. Reinf. active-inactive response ratio0.40.40.60.70.70.70.7-0.7-0.8-0.70.7-0.70.70.40.5
Condit. Reinf. active responses1.21.52.11.11.11.11.3-1.3-1.2-1.31.3-1.30.51.41.3
Condit. Reinf. inactive responses0.30.30.80.50.50.30.6-0.6-0.5-0.60.6-0.6-0.20.90.8
Incentive salience index mean0.40.60.80.70.70.70.9-0.9-0.8-0.80.8-0.80.50.70.8
Condit. Reinf. lever presses0.20.30.4-0.6-0.6-0.6-0.30.30.50.5-0.60.50.7-0.6-0.4
Condit. Reinf. active minus inactive responses0.20.33.70.20.2-0.00.1-0.1-0.1-0.10.2-0.21.90.20.3
Condit. Reinf. active-inactive response ratio1.11.72.21.41.41.21.3-1.3-1.4-1.41.5-1.40.51.51.4
Condit. Reinf. active responses0.30.53.5-0.4-0.4-0.6-0.50.50.50.5-0.40.31.9-0.4-0.1
Condit. Reinf. inactive responses1.01.51.7-1.1-1.1-1.3-1.21.21.31.3-1.31.21.3-1.3-0.9
Condit. Reinf. lever presses0.20.21.0-0.4-0.4-0.5-0.50.50.40.4-0.50.31.0-0.4-0.1
Condit. Reinf. lever reinforcers received0.40.63.5-0.5-0.5-0.8-0.60.60.60.6-0.50.51.9-0.5-0.2
Conditioned reinforcement - actives0.10.30.9-0.5-0.5-0.5-0.30.30.70.5-0.60.50.2-0.9-0.5
Conditioned reinforcement - inactives0.20.40.80.90.90.40.9-0.9-0.3-0.70.7-0.50.30.40.2
Conditioned locomotion0.10.10.4-0.1-0.1-0.20.3-0.30.20.1-0.00.30.6-0.3-0.5
Patch foraging indifference point 0 sec0.00.10.20.40.40.30.3-0.3-0.3-0.40.1-0.30.10.00.1
Patch foraging indifference point AUC0.00.10.6-0.2-0.2-0.4-0.30.30.40.2-0.20.20.8-0.10.1
Delay disc. indifference point, 0s delay0.10.10.6-0.4-0.4-0.1-0.0-0.10.30.1-0.00.20.7-0.3-0.0
Delay disc. indifference point, 16s delay2.84.05.2-2.2-2.2-2.1-1.91.82.32.0-2.02.01.4-2.0-1.8
Delay disc. indifference point, 2s delay0.10.10.2-0.4-0.4-0.30.3-0.40.5-0.00.20.20.2-0.3-0.3
Delay disc. indifference point, 24s delay0.60.91.8-1.0-1.0-1.1-0.70.61.31.0-0.71.10.5-1.1-1.3
Delay disc. indifference point, 4s delay0.10.10.3-0.5-0.5-0.3-0.0-0.10.30.1-0.20.2-0.4-0.4-0.2
Delay disc. indifference point, 8s delay0.10.10.3-0.5-0.5-0.30.0-0.10.50.1-0.10.20.1-0.6-0.3
Indifference point function ln k0.41.12.0-1.0-1.0-0.7-1.21.20.91.1-1.21.10.5-1.4-1.3
Indifference point function log k0.41.12.0-1.0-1.0-0.7-1.21.20.91.1-1.21.10.5-1.4-1.3
Patch foraging total patch changes 0 sec0.00.10.10.30.30.20.2-0.2-0.2-0.3-0.0-0.20.4-0.10.0
Patch foraging total patch changes 12 sec0.30.40.60.70.70.40.6-0.6-0.6-0.70.7-0.70.20.70.8
Patch foraging total patch changes 18 sec0.30.82.9-0.8-0.8-0.9-0.80.81.00.7-1.00.71.7-0.7-0.4
Patch foraging total patch changes 24 sec0.10.40.50.70.70.60.6-0.6-0.7-0.60.7-0.60.50.50.4
Patch foraging total patch changes 6 sec0.60.91.81.11.10.91.3-1.3-0.9-1.20.9-1.00.10.60.7
Patch foraging time to switch 0 sec0.00.20.4-0.5-0.5-0.5-0.10.10.40.3-0.50.4-0.6-0.4-0.5
Patch foraging water rate 0 sec0.10.51.00.90.90.80.4-0.3-0.7-0.70.8-0.90.20.61.0
Patch foraging water rate 12 sec0.10.63.2-0.5-0.5-0.5-0.70.80.70.7-0.60.61.8-0.6-0.4
Patch foraging water rate 18 sec0.20.41.8-0.4-0.4-0.3-0.70.70.40.5-0.40.51.4-0.5-0.5
Patch foraging water rate 24 sec0.30.54.7-0.2-0.2-0.1-0.50.60.40.4-0.20.22.20.0-0.1
Patch foraging water rate 6 sec0.40.64.3-0.5-0.5-0.3-0.50.50.50.4-0.30.52.1-0.8-0.3
Seeking ratio, delayed vs. immediate footshock0.40.60.70.80.80.70.8-0.8-0.8-0.80.8-0.8-0.30.80.8
Distance traveled before self-admin1.02.12.61.61.61.61.5-1.4-1.4-1.51.4-1.5-1.11.21.4
Distance traveled after self-admin0.20.32.40.60.60.3-0.00.1-0.2-0.1-0.1-0.3-1.60.30.4
Extensor digitorum longus weight0.41.53.1-1.2-1.2-1.1-1.41.51.21.0-1.11.11.8-0.9-0.8
Bone: elastic displacement1.31.62.41.41.41.51.4-1.3-1.4-1.51.4-1.3-0.11.10.9
Bone: elastic work9.512.416.33.83.84.03.7-3.6-3.8-3.83.8-3.6-0.63.32.9
Bone: endosteal estimation0.30.70.9-0.9-0.9-0.9-1.01.01.00.8-0.90.8-0.1-0.6-0.6
Bone: endosteal perimeter0.51.33.21.01.01.11.2-1.3-1.0-1.10.9-1.0-1.81.00.9
Epididymis fat weight0.10.71.11.01.01.10.9-0.9-0.9-0.90.7-0.80.20.30.3
Delta time in closed arm before/after self-admin1.41.32.5-1.3-1.3-1.2-0.90.91.21.0-1.31.10.5-1.6-0.9
Delta time in open arm before/after self-admin0.00.00.3-0.0-0.00.2-0.10.10.20.10.20.10.50.2-0.1
Diff in mean of infusions in LGA sessions0.81.47.21.11.10.91.0-0.9-1.0-0.90.8-1.0-2.70.91.0
Delay discount exponential model param0.81.11.71.31.31.20.8-0.7-1.3-1.00.9-1.1-0.41.31.1
Extinction: sum of active levers before priming0.10.10.9-0.2-0.20.2-0.20.20.10.20.20.30.90.2-0.4
Active lever presses in extinction session 61.61.62.61.31.31.41.6-1.6-1.3-1.31.6-1.2-0.30.80.7
Bone: final force3.15.17.12.42.42.72.2-2.2-2.5-2.42.4-2.31.81.81.7
Bone: final moment4.37.09.82.92.93.12.7-2.6-2.9-2.92.9-2.81.52.22.0
Food consumed during 24 hour testing period0.20.31.10.50.50.40.6-0.6-0.5-0.50.4-0.5-1.00.40.4
Glucose0.30.51.20.70.70.70.8-0.8-0.7-0.50.8-0.5-1.10.40.6
Heart weight1.01.72.71.31.31.41.1-1.0-1.5-1.21.6-1.21.31.41.1
Delay discount hyperbolic model param0.70.91.41.21.21.10.6-0.5-1.2-0.80.7-1.0-0.41.11.0
Intermittent access intake day 1-15 change0.42.25.81.51.51.21.2-1.2-1.3-1.41.0-1.5-2.41.41.6
Intermittent access intake escalation0.31.84.51.41.41.11.1-1.0-1.2-1.30.9-1.4-2.11.21.4
Intermittent access intake escalation 23.05.08.52.02.02.12.1-2.1-2.1-2.22.1-2.3-2.92.32.4
Intermitt. access day 1 inactive lever presses0.00.30.60.70.70.50.6-0.6-0.4-0.80.2-0.7-0.50.50.3
Intermitt. access day 15 inactive lever presses0.00.10.3-0.2-0.2-0.2-0.10.10.40.0-0.10.10.50.2-0.2
Intermitt. access escalation Index0.10.20.6-0.3-0.3-0.3-0.40.40.30.3-0.60.2-0.8-0.3-0.0
Intermittent access day 1 total infusions0.00.10.60.60.60.20.10.00.0-0.10.0-0.10.8-0.00.0
Intermittent access day 15 total infusions0.20.61.31.11.10.70.7-0.6-0.6-0.70.5-0.8-0.50.60.8
Intermittent access terminal intake (last 3 days)0.71.21.91.41.41.01.0-0.9-0.9-1.00.8-1.1-1.01.01.3
Intermittent access total infusions0.20.20.80.90.90.30.4-0.3-0.2-0.40.1-0.4-0.10.10.4
Intermittent access day 1 locomotion0.10.10.50.20.2-0.10.2-0.20.20.1-0.20.20.7-0.7-0.5
Intermittent access day 15 total locomotion0.20.81.61.31.30.81.1-1.1-0.8-1.00.7-0.9-0.50.80.6
Intermittent access total locomotion0.30.31.11.01.00.40.7-0.6-0.3-0.50.2-0.40.20.00.1
Intermittent access standard deviation0.21.01.70.90.91.11.1-1.1-0.9-1.00.9-1.0-1.30.60.7
Left kidney weight0.21.23.21.01.00.91.3-1.3-1.2-1.11.3-0.81.80.50.2
Right kidney weight0.11.07.30.70.70.70.9-0.9-0.8-0.70.9-0.42.70.1-0.2
Cocaine induced anxiety2.36.28.12.92.92.72.7-2.7-2.3-2.62.8-2.5-1.62.01.8
Post-drug Anxiety2.52.94.42.12.11.71.9-1.9-1.8-1.71.8-1.7-0.71.31.1
Baseline Anxiety0.71.21.9-1.4-1.4-1.3-1.11.00.71.1-1.21.10.8-0.9-0.8
Tail length1.47.49.22.72.72.63.0-3.0-2.8-3.02.5-2.8-2.72.42.4
Length with tail2.310.014.73.23.23.43.8-3.8-3.5-3.63.1-3.2-1.92.22.4
Length without tail1.05.28.22.42.42.52.8-2.9-2.6-2.42.6-2.20.11.41.6
Times rat made contact with spout3.64.29.91.81.81.61.9-1.9-1.8-2.01.9-1.9-3.22.31.9
Lifetime Intake0.10.10.60.80.80.10.2-0.10.0-0.1-0.1-0.10.0-0.10.0
Liver weight, left0.10.20.80.10.10.20.1-0.1-0.00.1-0.30.2-0.8-0.9-0.7
Liver weight, right0.91.63.31.31.31.31.7-1.8-1.3-1.51.2-1.2-0.90.80.4
Locomotor activity0.20.40.7-0.8-0.8-0.6-0.30.20.50.5-0.60.70.8-0.5-0.6
Locomotor testing distance0.82.13.0-1.7-1.7-1.3-1.11.01.31.4-1.51.61.1-1.7-1.6
Locomotor testing rearing0.31.11.5-1.2-1.2-1.1-1.01.01.01.1-1.21.10.0-1.0-0.9
Locomotion in novel chamber0.60.81.4-1.1-1.1-0.9-0.80.71.20.9-0.81.00.6-0.8-0.9
Locomotion in novel chamber post-restriction0.92.84.21.91.91.41.3-1.2-1.8-1.61.4-1.8-2.11.81.6
Fecal boli incidents, locomotor time 10.20.61.2-0.6-0.6-0.9-0.50.50.90.7-0.60.81.1-0.9-0.9
Change in fecal boli incidents, locomotor task0.40.43.20.30.30.40.3-0.3-0.3-0.30.2-0.5-1.80.50.7
Time >=10cm from walls, locomotor time 10.30.41.2-0.3-0.3-0.7-1.01.10.60.7-0.90.5-0.00.0-0.2
Bouts of movement, locomotor time 10.40.50.9-0.5-0.5-0.5-0.91.00.40.8-0.70.80.4-0.6-0.8
Total resting periods, locomotor time 10.30.40.7-0.4-0.4-0.4-0.80.80.20.7-0.50.70.1-0.5-0.8
Rest time, locomotor task time 10.20.41.30.50.50.40.7-0.7-0.5-0.60.7-0.4-1.10.40.1
Distance moved, locomotor task time 10.00.10.2-0.3-0.30.2-0.20.2-0.00.1-0.4-0.1-0.4-0.10.4
Vertical activity count, locomotor time 10.00.00.1-0.1-0.10.1-0.30.30.20.2-0.40.10.20.10.1
Time >=10cm from walls, locomotor time 20.00.11.2-0.1-0.1-0.1-0.00.00.1-0.10.1-0.01.10.50.2
Bouts of movement, locomotor time 20.31.01.7-0.5-0.5-1.0-1.11.20.91.1-1.31.10.1-1.2-1.3
Total resting periods, locomotor time 20.31.22.0-0.7-0.7-1.2-1.21.21.01.2-1.41.20.2-1.4-1.4
Rest time, locomotor task time 20.20.32.80.20.2-0.1-0.00.10.00.1-0.30.1-1.7-0.4-0.2
Distance moved, locomotor task time 20.10.21.1-0.5-0.5-0.0-0.20.10.20.1-0.10.11.0-0.00.2
Vertical activity count, locomotor time 20.30.63.9-0.6-0.6-0.5-0.60.60.60.6-0.50.62.0-0.2-0.4
Light reinforcement 10.00.10.2-0.4-0.4-0.2-0.40.40.40.4-0.40.30.10.1-0.2
Light reinforcement 20.10.30.50.50.50.70.7-0.7-0.5-0.60.5-0.5-0.50.60.3
Bone: marrow area0.30.70.9-1.0-1.0-0.9-1.01.01.00.8-0.90.8-0.0-0.6-0.6
Bone: maximum diameter0.91.82.91.41.41.61.7-1.7-1.4-1.51.3-1.30.50.90.8
Bone: maximum force2.44.75.92.22.22.42.2-2.2-2.3-2.32.3-2.22.21.81.7
Bone: maximum moment3.36.38.32.62.62.92.6-2.6-2.7-2.72.7-2.61.82.22.0
Mean time between licks in bursts0.21.52.1-1.2-1.2-1.2-1.21.21.21.2-1.31.30.7-1.5-1.2
Mean num. licks in bursts0.71.93.61.21.21.11.3-1.4-1.3-1.41.3-1.3-1.91.61.4
Cd content in liver1.51.72.3-1.4-1.4-1.5-1.31.31.51.2-1.41.31.1-1.0-1.0
Co content in liver0.10.10.20.30.30.30.5-0.5-0.3-0.50.3-0.2-0.50.2-0.0
Cu content in liver2.22.73.31.71.71.81.7-1.7-1.7-1.81.5-1.6-1.81.31.2
Fe content in liver0.70.81.4-0.9-0.9-0.8-1.01.00.80.9-1.00.9-0.1-1.2-1.0
K content in liver0.10.10.3-0.0-0.0-0.3-0.20.20.30.2-0.50.2-0.5-0.6-0.4
Mg content in liver1.41.52.2-1.2-1.2-1.5-1.31.31.41.2-1.51.20.4-1.1-1.0
Mn content in liver0.10.10.90.10.10.0-0.00.0-0.00.1-0.00.01.0-0.1-0.1
Na content in liver0.40.40.7-0.4-0.4-0.5-0.70.80.60.7-0.80.6-0.5-0.8-0.7
Rb content in liver0.00.10.40.10.1-0.1-0.10.10.1-0.00.1-0.10.60.40.2
Se content in liver0.00.00.10.20.20.10.2-0.2-0.1-0.20.1-0.2-0.40.30.2
Sr content in liver0.60.50.70.80.80.80.7-0.7-0.7-0.70.8-0.7-0.70.80.7
Zn content in liver0.30.40.70.60.60.40.6-0.6-0.5-0.70.4-0.6-0.80.80.6
Bone: minimum diameter2.65.17.52.42.42.62.7-2.7-2.5-2.52.3-2.2-0.61.81.4
Time in familiar zone, hab. session 10.10.10.30.30.30.30.3-0.3-0.3-0.30.5-0.4-0.00.60.4
Time in novel zone, hab. session 10.10.10.2-0.3-0.3-0.2-0.40.40.30.3-0.40.30.3-0.3-0.3
Total zone transitions, hab. session 10.60.92.2-0.9-0.9-0.8-1.01.00.90.9-0.80.91.5-0.9-0.6
Total locomotion distance, hab. session 10.20.31.7-0.4-0.4-0.3-0.50.50.50.5-0.40.51.3-0.5-0.5
Locomotion velocity, hab. session 10.20.31.6-0.4-0.4-0.3-0.50.60.40.5-0.40.51.3-0.5-0.5
Time in familiar zone, hab. session 20.30.30.6-0.6-0.6-0.6-0.70.80.60.6-0.50.60.5-0.3-0.5
Time in novel zone, hab. session 20.10.10.3-0.2-0.2-0.2-0.10.00.10.1-0.20.20.6-0.4-0.1
Total zone transitions, hab. session 22.53.25.3-1.8-1.8-1.9-1.81.81.81.7-1.81.62.3-1.7-1.3
Total locomotion distance, hab. session 21.21.64.1-1.3-1.3-1.3-1.21.21.21.2-1.21.12.0-1.1-0.9
Locomotion velocity, hab. session 20.91.13.7-1.0-1.0-1.0-1.01.01.00.9-1.00.91.9-0.9-0.7
Novel to familiar place preference ratio3.34.35.02.22.22.22.2-2.2-2.2-2.22.2-2.1-0.82.01.8
Novelty place preference3.34.25.02.22.22.22.2-2.2-2.2-2.22.2-2.1-0.72.01.8
Time in novel zone, NPP test2.63.23.71.91.91.91.9-1.9-1.9-1.91.9-1.9-0.51.71.6
Total zone transitions, NPP test3.34.95.5-2.3-2.3-2.3-2.32.32.22.2-2.32.12.2-2.2-1.8
Total locomotion distance, NPP test2.53.55.4-1.9-1.9-1.9-1.91.91.81.8-1.81.82.3-1.7-1.5
Locomotion velocity, NPP test1.41.93.6-1.4-1.4-1.4-1.41.41.31.4-1.41.31.9-1.3-1.1
Intraocular pressure0.10.10.30.00.00.10.2-0.2-0.5-0.30.4-0.5-0.50.60.5
Delta distance traveled before/after self-admin0.80.91.6-0.7-0.7-1.0-1.21.31.01.1-1.21.0-0.3-0.8-0.8
Delta ambulatory time before/after self-admin1.32.33.4-1.4-1.4-1.7-1.71.81.61.7-1.81.6-0.4-1.4-1.3
Parametrial fat weight0.10.10.30.40.40.30.4-0.4-0.4-0.40.2-0.3-0.50.40.2
Pavlov. Cond. lever latency2.83.54.2-1.9-1.9-2.0-2.02.02.01.9-1.91.91.4-1.6-1.7
Pavlov. Cond. magazine entry latency3.84.95.82.32.32.42.1-2.1-2.4-2.32.3-2.3-1.62.12.1
Pavlov. Cond. change in total contacts2.12.23.01.61.61.71.5-1.5-1.7-1.51.6-1.5-1.01.31.1
Pavlov. Cond. index score3.95.05.82.42.42.42.3-2.3-2.4-2.32.3-2.4-1.42.12.1
Pavlov. Cond. latency score3.95.05.82.32.32.42.3-2.3-2.4-2.32.3-2.3-1.62.02.1
Pavlov. Cond. lever contacts1.41.62.01.41.41.41.4-1.4-1.4-1.31.3-1.3-0.91.01.1
Pavlov. Cond. magazine entry number5.57.08.3-2.8-2.8-2.8-2.62.62.92.7-2.82.81.8-2.5-2.5
Pavlov. Cond. intertrial magazine entries0.30.31.0-0.6-0.6-0.7-0.50.50.60.4-0.50.51.0-0.3-0.4
Pavlov. Cond. lever-magazine prob. diff.3.84.75.72.32.32.42.2-2.2-2.4-2.32.2-2.3-1.22.02.0
Pavlov. Cond. response bias3.94.95.82.32.32.42.2-2.2-2.4-2.32.3-2.3-1.42.12.1
Pavlov. Cond. lever latency0.10.10.40.40.40.40.4-0.3-0.4-0.20.3-0.2-0.60.0-0.2
Pavlov. Cond. magazine entry latency2.53.54.2-2.1-2.1-1.9-2.02.01.91.9-1.91.91.0-2.0-1.6
Pavlov. Cond. change in total contacts0.51.11.6-1.2-1.2-1.1-1.31.31.11.1-1.11.00.8-0.9-0.6
Pavlov. Cond. index score0.50.81.1-1.0-1.0-1.0-1.01.00.90.9-0.90.80.6-0.9-0.5
Pavlov. Cond. latency score0.61.01.4-1.2-1.2-1.1-1.11.11.01.0-1.01.00.7-1.0-0.7
Pavlov. Cond. lever contacts0.10.20.3-0.5-0.5-0.5-0.50.50.50.4-0.50.30.5-0.10.1
Pavlov. Cond. magazine entry number1.92.53.11.71.71.61.6-1.6-1.6-1.61.7-1.6-0.71.71.3
Pavlov. Cond. intertrial magazine entries0.30.50.90.80.80.60.7-0.7-0.7-0.70.8-0.80.41.00.8
Pavlov. Cond. lever-magazine prob. diff.0.71.01.3-1.2-1.2-1.1-1.11.11.01.0-1.11.00.6-1.0-0.7
Pavlov. Cond. response bias0.50.70.9-1.0-1.0-0.9-0.90.90.90.8-0.90.70.7-0.7-0.3
Time in closed arm before self-admin0.20.31.00.80.80.60.2-0.1-1.0-0.30.3-0.4-0.30.40.3
Time in closed arm after self-admin0.20.21.50.30.3-0.0-0.10.1-0.60.0-0.3-0.1-1.2-0.30.0
Time in open arm before self-admin0.60.71.7-1.3-1.3-0.9-0.40.21.00.6-0.50.80.8-0.7-0.7
Time in open arm after self-admin0.50.62.7-0.8-0.8-0.5-0.50.40.90.5-0.30.61.6-0.4-0.6
Bone: periosteal estimation0.61.42.11.31.31.41.3-1.3-1.3-1.41.2-1.20.80.90.7
Bone: periosteal perimeter4.07.810.42.82.83.23.2-3.2-3.0-3.13.0-2.9-1.02.52.3
Bone: post-yield work0.20.41.2-0.8-0.8-0.7-0.50.50.60.6-0.50.61.1-0.4-0.3
Progressive ratio test 1 active lever presses0.10.20.90.90.90.40.3-0.2-0.4-0.3-0.0-0.4-0.00.00.3
Progressive ratio test 1 breakpoint0.20.31.11.01.00.50.4-0.3-0.5-0.40.0-0.5-0.10.10.4
Progressive ratio test 1 inactive lever presses0.10.30.70.80.80.60.5-0.4-0.4-0.60.4-0.60.30.50.5
Progressive ratio test 2 active lever presses0.20.20.91.01.00.10.5-0.4-0.1-0.30.2-0.3-0.20.20.2
Progressive ratio test 2 breakpoint0.20.20.91.01.00.20.5-0.4-0.1-0.40.3-0.4-0.20.20.3
Progressive ratio test 2 inactive lever presses0.20.81.71.31.30.71.1-1.0-0.6-0.90.7-0.8-0.30.50.6
Incentive Sensitization - Responses0.10.20.70.80.8-0.00.4-0.30.1-0.30.3-0.3-0.50.40.3
Incentive Sensitization - Breakpoint0.10.20.70.80.8-0.00.4-0.40.0-0.30.4-0.3-0.50.40.3
Sum of active levers in priming session hrs 5-62.72.53.61.61.61.51.6-1.6-1.9-1.61.7-1.6-1.31.61.6
Progressive ratio0.20.61.4-0.8-0.8-0.7-0.60.60.70.7-0.60.71.2-0.7-0.8
Food seeking constrained by brief footshock0.50.73.20.50.50.60.7-0.8-0.6-0.70.8-0.6-1.80.90.4
Seeking ratio, punishment vs. effort0.00.00.40.20.20.10.1-0.1-0.0-0.10.1-0.1-0.60.3-0.0
Retroperitoneal fat weight0.62.73.92.02.01.91.6-1.5-2.0-1.71.6-1.7-1.11.51.1
Reaction time number correct1.86.28.7-2.5-2.5-2.4-2.72.72.42.5-2.52.42.9-2.2-1.8
Reaction time mean minus median0.10.31.30.60.60.60.3-0.3-0.4-0.40.5-0.4-1.10.70.4
Reaction time mean minus median AUC0.00.00.20.10.10.2-0.00.0-0.1-0.10.2-0.1-0.40.40.3
Reaction time num false alarms0.00.10.2-0.2-0.2-0.2-0.30.30.10.3-0.20.30.40.0-0.3
Reaction time num false alarms AUC0.20.40.5-0.7-0.7-0.7-0.60.60.50.7-0.60.70.7-0.4-0.7
Reaction time trials correct on left1.86.28.7-2.5-2.5-2.4-2.72.72.42.5-2.52.42.9-2.2-1.8
Reaction time trials on left1.96.49.1-2.6-2.6-2.4-2.72.82.52.6-2.52.43.0-2.2-1.8
Reaction time mean0.00.10.60.20.20.20.1-0.1-0.1-0.20.2-0.20.40.80.3
Reaction time mean AUC0.00.10.5-0.3-0.3-0.1-0.30.30.30.2-0.20.30.70.3-0.1
Median of all reaction times0.10.10.9-0.0-0.00.0-0.00.00.1-0.00.00.00.90.50.1
Reaction time omissions0.00.00.2-0.2-0.20.00.1-0.20.0-0.0-0.10.10.40.0-0.2
Reaction time false alarm rate0.30.50.80.70.70.60.8-0.8-0.7-0.60.7-0.6-0.90.80.3
Reaction time premature initiation rate0.40.61.1-0.7-0.7-1.0-0.70.70.70.8-0.60.80.5-0.9-0.8
Reaction time premature initiations1.33.84.8-1.9-1.9-2.2-2.12.11.92.1-1.92.01.9-1.9-1.6
Std. dev. reaction times0.10.30.6-0.5-0.5-0.4-0.70.80.60.6-0.50.50.20.0-0.3
Reaction time trials completed1.96.49.1-2.6-2.6-2.4-2.72.82.52.6-2.52.43.0-2.2-1.8
Reaction time trials AUC1.86.39.2-2.5-2.5-2.4-2.72.72.42.6-2.52.43.0-2.2-1.8
Run reversals in cocaine runway, females1.61.72.9-1.1-1.1-1.4-1.61.71.71.5-1.21.41.0-0.8-1.2
Run reversals in cocaine runway, males3.13.44.21.81.81.81.9-1.9-1.9-1.92.0-1.9-1.71.81.8
Latency to leave start box in cocaine runway0.60.81.4-1.0-1.0-0.8-1.00.90.90.9-0.80.90.2-1.2-0.8
Latency to leave start box in cocaine runway, F1.82.32.7-1.6-1.6-1.6-1.51.41.61.5-1.11.61.2-1.5-1.6
Latency to leave start box in cocaine runway, M0.20.20.90.40.40.40.2-0.2-0.5-0.4-0.0-0.5-1.0-0.00.6
Std. dev. time between licks in bursts1.42.73.9-1.7-1.7-1.6-1.71.71.71.5-1.71.52.0-1.4-1.3
Total sessions with >9 infusions0.20.30.50.10.1-0.3-0.50.60.60.5-0.60.50.6-0.7-0.6
Short access day 1 total inactive lever presses0.30.52.0-0.5-0.5-0.6-0.0-0.10.60.4-0.40.71.4-0.9-1.1
Short access day 10 total inactive lever presses0.10.71.20.80.80.80.9-1.0-0.7-1.10.8-1.0-0.10.90.7
Short access day 1 total infusions0.61.21.7-0.7-0.7-0.9-1.11.21.21.2-1.11.21.2-1.2-1.3
Short access day 10 total infusions0.91.62.91.71.71.21.2-1.1-1.1-1.21.0-1.2-1.21.01.1
Short access total infusions0.10.10.60.80.80.10.00.10.10.1-0.20.00.0-0.2-0.2
Short access day 1 locomotion0.00.00.20.40.40.3-0.00.1-0.2-0.1-0.0-0.10.40.0-0.0
Short access day 10 total locomotion0.21.01.41.01.01.01.2-1.2-0.8-1.01.1-0.9-0.80.80.7
Short access total locomotion0.40.61.01.01.00.90.9-0.9-0.6-0.80.7-0.7-0.40.50.5
One hour access (0.3 mA shock)0.10.10.30.60.60.0-0.10.20.2-0.00.0-0.00.20.10.1
Compulsive drug intake0.10.20.4-0.4-0.4-0.4-0.50.60.20.4-0.40.4-0.6-0.2-0.3
One hour access (shock baseline)0.00.10.30.40.4-0.10.1-0.00.30.0-0.2-0.00.5-0.30.1
Social response proportion0.60.71.0-0.8-0.8-0.9-0.80.80.80.8-0.90.81.0-0.9-0.7
Social responses0.40.51.6-0.5-0.5-0.4-0.50.50.70.6-0.90.70.8-1.2-1.0
Social time0.30.53.4-0.6-0.6-0.4-0.40.30.40.4-0.50.61.8-0.6-0.8
Soleus weight0.51.52.31.11.11.31.1-1.1-1.3-1.41.3-1.3-0.71.51.3
Bone: stiffness0.40.76.60.30.30.50.4-0.4-0.4-0.30.4-0.32.6-0.10.0
Tibialis anterior weight0.10.30.6-0.6-0.6-0.6-0.70.70.60.5-0.60.50.8-0.3-0.3
Time to tail flick, vehicle, before self-admin0.10.10.3-0.4-0.4-0.5-0.20.20.60.3-0.10.40.30.1-0.4
Time to tail flick, vehicle, after self-admin0.81.62.7-1.1-1.1-1.3-1.01.01.11.3-1.21.40.9-1.7-1.6
Time to tail flick, test, before self-admin0.10.10.70.00.0-0.30.1-0.10.1-0.1-0.2-0.0-0.8-0.2-0.2
Time to tail flick, test, after self-admin0.10.10.30.50.5-0.10.4-0.3-0.1-0.1-0.10.0-0.5-0.5-0.3
Delta time to tail flick, vehicle, before/after SA0.40.41.0-0.6-0.6-0.6-0.60.60.40.7-0.70.70.1-1.0-0.7
Delta time to tail flick, test, before/after SA0.10.10.20.40.40.40.4-0.4-0.3-0.20.4-0.20.50.00.2
Tibia length8.022.328.35.05.05.35.0-4.9-5.1-5.15.1-5.0-0.54.54.1
Ambulatory time before self-admin1.03.14.01.91.92.01.8-1.8-1.8-1.91.9-1.9-0.51.71.7
Ambulatory time after self-admin0.10.10.40.50.50.30.10.0-0.1-0.20.1-0.3-0.70.40.3
Bone: tissue strength0.40.52.40.40.40.70.5-0.6-0.6-0.70.6-0.51.50.30.1
Total heroin consumption1.31.52.91.71.71.41.4-1.4-1.0-1.11.4-1.0-0.41.00.6
Bone: trabecular number0.00.00.30.10.10.00.1-0.1-0.1-0.10.1-0.2-0.50.30.3
Bone: trabecular spacing1.31.92.5-1.4-1.4-1.4-1.31.31.41.3-1.51.31.6-1.5-1.3
Bone: trabecular thickness2.73.74.51.91.91.91.9-1.9-2.0-1.92.0-1.9-1.82.11.8
Bone: trabecular tissue density0.61.11.5-1.0-1.0-1.0-1.21.21.01.1-1.01.10.8-0.9-0.9
Water consumed over 24 hours0.50.93.50.80.80.80.9-1.0-0.8-0.90.7-0.8-1.90.70.7
Number of responses in last shaping day0.10.21.0-0.4-0.40.00.1-0.2-0.00.0-0.20.21.0-0.8-0.4