Hub : Genes

Lrrc45

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Lrrc45 0.05 0.03 9.0e-05 0.04 0.04 0.04 0.04 2.2e-05 3.6e-05 4.4e-05 3.2e-05
2 Liver intron excision ratio chr10_106492949_106493168 0.02 0.01 6.2e-03 0.01 0.01 0.01 0.01 9.9e-03 1.0e-02 2.8e-02 2.3e-02
3 Adipose gene expression Lrrc45 0.51 0.15 0.0e+00 0.38 0.4 0.38 0.39 3.5e-44 7.3e-47 8.9e-44 5.7e-46
4 BLA gene expression Lrrc45 0.14 0.09 3.7e-06 0.09 0.1 0.1 0.1 1.4e-05 9.8e-06 9.7e-06 9.2e-06
5 LHb gene expression Lrrc45 0.43 0.21 1.5e-04 0.08 0.08 0.02 0.07 5.8e-03 6.2e-03 9.5e-02 7.6e-03
6 pVTA gene expression Lrrc45 0.15 0.08 2.0e-12 0.16 0.16 0.15 0.16 1.2e-12 1.7e-12 2.6e-12 1.7e-12
7 Brain gene expression Lrrc45 0.2 0.1 7.8e-16 0.16 0.17 0.17 0.17 6.1e-15 3.0e-15 6.0e-16 1.9e-15
8 NAcc gene expression Lrrc45 0.25 0.13 0.0e+00 0.23 0.22 0.22 0.23 9.6e-34 4.4e-33 2.4e-33 3.1e-34
9 Liver gene expression Lrrc45 0.48 0.13 0.0e+00 0.5 0.53 0.53 0.53 3.2e-64 5.3e-69 1.1e-69 8.9e-69
10 IL gene expression Lrrc45 0.3 0.2 6.3e-04 0.13 0.13 0.21 0.1 6.3e-04 6.3e-04 9.0e-06 2.4e-03
11 PL gene expression Lrrc45 0.46 0.22 3.5e-13 0.12 0.12 0.12 0.13 9.4e-13 2.1e-13 3.0e-13 7.5e-14
12 Liver mRNA stability Lrrc45 0.45 0.14 0.0e+00 0.32 0.32 0.34 0.32 2.4e-36 1.3e-36 6.3e-39 7.0e-37

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.00.00.0-0.1-0.1-0.0-0.0-0.00.00.0-0.1-0.0-0.1-0.00.1
Area under the delay curve1.11.32.01.41.4-1.3-0.9-0.8-1.4-1.1-1.0-1.2-0.6-1.31.1
BMI with tail0.30.98.0-0.8-0.80.70.30.20.50.30.70.3-2.80.20.3
BMI without tail0.41.31.9-1.4-1.41.21.11.01.41.31.21.2-0.41.2-0.8
Body weight1.46.28.3-2.8-2.82.82.72.62.92.72.82.5-1.02.0-1.6
Weight adjusted by age1.42.23.5-1.1-1.11.51.71.81.61.61.91.50.31.6-1.4
Bone surface0.20.42.6-0.5-0.50.40.50.40.40.60.40.41.60.6-0.5
Bone volume0.10.21.1-0.5-0.50.40.40.30.30.50.30.41.00.5-0.3
Breakpoint value in progressive ratio session2.53.13.6-1.9-1.91.81.81.81.81.81.91.81.31.6-1.5
Number of licking bursts0.10.10.20.30.3-0.3-0.4-0.4-0.4-0.4-0.4-0.4-0.2-0.40.4
Context. condit. distance diff. score0.70.81.21.11.1-1.0-1.1-1.1-1.0-1.0-1.0-0.8-0.4-0.70.5
Locomotion velocity, session 10.00.00.0-0.0-0.0-0.1-0.2-0.2-0.0-0.10.1-0.10.10.2-0.1
Locomotion distance, session 13.74.65.72.12.1-2.1-2.1-2.1-2.1-2.1-2.1-2.2-2.4-2.32.0
Locomotion velocity, session 21.61.92.21.41.4-1.5-1.5-1.5-1.4-1.5-1.3-1.5-0.6-1.51.3
Locomotion distance, session 21.52.15.11.41.4-1.4-1.3-1.2-1.4-1.3-1.4-1.3-2.2-1.51.1
Locomotion velocity, session 30.20.20.70.30.3-0.3-0.5-0.5-0.4-0.5-0.5-0.5-0.1-0.80.7
Locomotion distance, session 31.81.93.01.31.3-1.2-1.5-1.5-1.2-1.4-1.4-1.4-1.1-1.71.5
Stereotopy head waving bouts, day 30.00.00.10.00.00.00.00.0-0.00.00.0-0.1-0.3-0.10.3
Stereotopy head waving duration, day 30.10.20.30.30.3-0.3-0.4-0.5-0.4-0.4-0.3-0.4-0.6-0.30.5
Locomotion velocity, session 70.60.61.00.80.8-0.7-0.8-0.8-0.7-0.8-0.9-0.80.6-1.00.8
Locomotion distance, session 74.86.17.62.52.5-2.5-2.7-2.8-2.6-2.6-2.6-2.5-1.4-2.52.1
Stereotopy head waving bouts, day 70.20.20.3-0.4-0.40.50.30.20.60.40.60.4-0.20.5-0.2
Stereotopy head waving duration, day 70.20.20.3-0.5-0.50.60.40.30.60.50.60.40.00.5-0.1
Locomotion velocity, session 82.32.74.91.61.6-1.7-1.6-1.5-1.7-1.6-1.6-1.5-2.2-1.71.3
Locomotion distance, session 83.04.46.22.22.2-2.1-2.1-2.1-2.1-2.0-2.2-1.9-2.5-2.01.6
Degree of sensitization distance0.10.10.20.40.4-0.4-0.3-0.3-0.5-0.2-0.3-0.20.50.2-0.2
Degree of sensitization stereotypy0.10.10.2-0.2-0.20.30.10.10.40.20.40.3-0.50.3-0.1
Conditioned locomotion0.40.50.8-0.7-0.70.50.80.80.50.70.60.8-0.10.9-0.7
Cocaine response after cond. corrected0.20.30.4-0.6-0.60.50.50.50.60.50.50.50.60.3-0.3
Cocaine response after cond. not corrected0.00.00.3-0.1-0.1-0.00.00.00.1-0.1-0.1-0.00.6-0.40.2
Cocaine response before conditioning1.41.62.71.31.3-1.2-1.2-1.2-1.3-1.2-1.5-1.3-0.4-1.71.3
Saline control response0.71.01.2-1.1-1.10.91.11.11.01.10.81.00.90.9-0.8
Bone: connectivity density0.40.60.90.90.9-0.9-0.8-0.8-0.9-0.8-0.9-0.8-0.0-0.60.6
Bone: cortical apparent density1.11.51.91.11.1-1.2-1.3-1.4-1.2-1.3-1.2-1.3-0.6-1.31.3
Bone: cortical area4.16.38.7-2.7-2.72.92.82.82.72.72.62.5-1.91.8-1.6
Bone: cortical porosity4.44.86.0-2.3-2.32.42.42.42.42.32.32.11.41.8-1.7
Bone: cortical porosity4.64.96.4-2.3-2.32.52.52.52.42.42.42.21.32.0-1.8
Bone: cortical thickness5.18.511.5-3.1-3.13.43.13.13.23.13.12.8-2.82.0-1.8
Bone: cortical thickness1.51.82.5-1.5-1.51.51.41.41.41.31.41.2-1.60.8-0.7
Bone: cortical tissue density1.11.52.01.21.2-1.2-1.4-1.4-1.2-1.3-1.2-1.3-0.4-1.21.3
Condit. Reinf. active minus inactive responses0.80.91.0-0.9-0.90.91.01.01.01.01.01.0-0.61.0-1.0
Condit. Reinf. active-inactive response ratio0.40.40.6-0.7-0.70.70.70.70.80.70.70.7-0.70.4-0.5
Condit. Reinf. active responses1.21.52.1-1.1-1.11.11.31.31.21.31.31.3-0.51.4-1.3
Condit. Reinf. inactive responses0.30.30.8-0.5-0.50.30.60.60.50.60.60.60.10.9-0.8
Incentive salience index mean0.50.60.8-0.7-0.70.70.90.90.80.80.80.8-0.50.7-0.8
Condit. Reinf. lever presses0.20.30.40.60.6-0.6-0.3-0.3-0.5-0.5-0.6-0.5-0.6-0.60.4
Condit. Reinf. active minus inactive responses0.30.33.7-0.2-0.2-0.00.10.10.10.10.20.2-1.90.2-0.3
Condit. Reinf. active-inactive response ratio1.51.82.2-1.4-1.41.21.31.31.41.41.51.4-0.51.5-1.4
Condit. Reinf. active responses0.30.53.50.40.4-0.6-0.5-0.5-0.5-0.5-0.4-0.3-1.9-0.40.1
Condit. Reinf. inactive responses1.11.51.71.11.1-1.3-1.2-1.2-1.3-1.3-1.3-1.2-1.2-1.31.0
Condit. Reinf. lever presses0.20.21.00.40.4-0.5-0.5-0.5-0.4-0.4-0.5-0.3-1.0-0.40.1
Condit. Reinf. lever reinforcers received0.40.53.40.50.5-0.8-0.6-0.6-0.6-0.6-0.5-0.5-1.9-0.50.2
Conditioned reinforcement - actives0.20.30.90.50.5-0.5-0.3-0.3-0.7-0.5-0.6-0.5-0.1-0.90.5
Conditioned reinforcement - inactives0.30.40.8-0.9-0.90.40.90.90.30.70.70.5-0.30.4-0.2
Conditioned locomotion0.10.10.40.10.1-0.20.30.3-0.2-0.1-0.0-0.3-0.7-0.30.5
Patch foraging indifference point 0 sec0.00.10.2-0.4-0.40.30.30.30.30.40.10.3-0.10.0-0.1
Patch foraging indifference point AUC0.10.10.60.20.2-0.4-0.3-0.3-0.4-0.2-0.2-0.2-0.8-0.1-0.1
Delay disc. indifference point, 0s delay0.10.10.50.40.4-0.1-0.00.1-0.3-0.1-0.0-0.2-0.7-0.30.0
Delay disc. indifference point, 16s delay3.63.95.22.22.2-2.1-1.9-1.8-2.3-2.0-2.0-2.0-1.3-2.01.8
Delay disc. indifference point, 2s delay0.10.10.20.40.4-0.30.30.4-0.50.00.2-0.2-0.2-0.30.3
Delay disc. indifference point, 24s delay0.80.91.81.01.0-1.1-0.7-0.6-1.3-1.0-0.7-1.1-0.5-1.11.3
Delay disc. indifference point, 4s delay0.10.10.30.50.5-0.3-0.00.1-0.3-0.1-0.2-0.20.5-0.50.2
Delay disc. indifference point, 8s delay0.10.10.30.50.5-0.30.00.1-0.5-0.1-0.1-0.2-0.0-0.60.3
Indifference point function ln k0.71.12.01.01.0-0.7-1.2-1.2-0.9-1.1-1.2-1.1-0.5-1.41.2
Indifference point function log k0.71.12.01.01.0-0.7-1.2-1.2-0.9-1.1-1.2-1.1-0.5-1.41.2
Patch foraging total patch changes 0 sec0.00.10.1-0.3-0.30.20.20.20.20.3-0.00.2-0.4-0.1-0.0
Patch foraging total patch changes 12 sec0.30.40.6-0.7-0.70.40.60.60.60.70.70.7-0.30.7-0.8
Patch foraging total patch changes 18 sec0.50.83.00.80.8-0.9-0.8-0.8-1.0-0.7-1.0-0.7-1.7-0.70.4
Patch foraging total patch changes 24 sec0.20.40.5-0.7-0.70.60.60.60.70.60.70.6-0.50.5-0.4
Patch foraging total patch changes 6 sec0.60.91.8-1.1-1.10.91.31.30.91.20.91.0-0.10.6-0.7
Patch foraging time to switch 0 sec0.10.20.40.50.5-0.5-0.1-0.1-0.4-0.3-0.5-0.50.6-0.40.5
Patch foraging water rate 0 sec0.20.51.0-0.9-0.90.80.40.30.70.70.80.9-0.10.6-1.0
Patch foraging water rate 12 sec0.30.63.10.50.5-0.5-0.7-0.8-0.7-0.7-0.6-0.6-1.8-0.60.4
Patch foraging water rate 18 sec0.20.41.70.40.4-0.3-0.7-0.7-0.4-0.5-0.4-0.5-1.3-0.50.4
Patch foraging water rate 24 sec0.30.54.70.20.2-0.1-0.5-0.6-0.4-0.4-0.2-0.2-2.20.00.1
Patch foraging water rate 6 sec0.40.64.20.50.5-0.3-0.5-0.5-0.5-0.4-0.3-0.5-2.0-0.80.3
Seeking ratio, delayed vs. immediate footshock0.50.60.7-0.8-0.80.70.80.80.80.80.80.80.30.8-0.8
Distance traveled before self-admin1.62.12.6-1.6-1.61.61.51.41.41.51.41.51.11.2-1.4
Distance traveled after self-admin0.30.32.4-0.6-0.60.3-0.0-0.10.20.1-0.10.31.60.3-0.4
Extensor digitorum longus weight0.41.43.01.21.2-1.1-1.4-1.5-1.2-1.0-1.1-1.1-1.7-0.90.8
Bone: elastic displacement1.41.62.4-1.4-1.41.51.41.31.41.51.41.30.11.1-0.9
Bone: elastic work9.512.416.3-3.8-3.84.03.73.63.83.83.83.60.63.3-2.9
Bone: endosteal estimation0.30.70.90.90.9-0.9-1.0-1.0-1.0-0.8-0.9-0.80.1-0.60.6
Bone: endosteal perimeter0.61.33.3-1.0-1.01.11.21.31.01.10.91.01.81.0-0.9
Epididymis fat weight0.20.71.1-1.0-1.01.10.90.90.90.90.70.8-0.10.3-0.3
Delta time in closed arm before/after self-admin1.41.32.51.31.3-1.2-0.9-0.9-1.2-1.0-1.3-1.1-0.5-1.60.9
Delta time in open arm before/after self-admin0.00.00.40.00.00.2-0.1-0.1-0.2-0.10.2-0.1-0.60.20.1
Diff in mean of infusions in LGA sessions1.21.47.2-1.1-1.10.91.00.91.00.90.80.92.70.9-1.0
Delay discount exponential model param1.01.11.7-1.3-1.31.20.80.71.31.00.91.10.41.3-1.1
Extinction: sum of active levers before priming0.10.11.00.20.20.2-0.2-0.2-0.1-0.20.2-0.3-1.00.20.4
Active lever presses in extinction session 61.61.62.6-1.3-1.31.41.61.61.31.31.61.10.30.8-0.7
Bone: final force3.25.17.1-2.4-2.42.72.22.22.52.42.42.3-1.91.8-1.7
Bone: final moment4.47.09.8-2.9-2.93.12.72.62.92.92.92.8-1.52.2-2.0
Food consumed during 24 hour testing period0.20.31.1-0.5-0.50.40.60.60.50.60.40.51.10.4-0.4
Glucose0.30.51.0-0.7-0.70.70.80.80.70.50.80.51.00.4-0.6
Heart weight1.11.72.7-1.3-1.31.41.11.01.51.21.61.2-1.31.4-1.1
Delay discount hyperbolic model param0.80.91.4-1.2-1.21.10.60.51.20.80.71.00.31.1-1.0
Intermittent access intake day 1-15 change1.12.26.0-1.5-1.51.21.21.21.31.41.01.52.41.4-1.6
Intermittent access intake escalation0.91.84.6-1.4-1.41.11.11.01.21.30.91.42.21.2-1.4
Intermittent access intake escalation 24.45.18.6-2.0-2.02.12.12.12.12.22.12.32.92.3-2.4
Intermitt. access day 1 inactive lever presses0.10.30.6-0.7-0.70.50.60.60.40.80.20.70.60.5-0.3
Intermitt. access day 15 inactive lever presses0.00.10.30.20.2-0.2-0.1-0.1-0.4-0.0-0.1-0.1-0.50.20.2
Intermitt. access escalation Index0.10.20.70.30.3-0.3-0.4-0.4-0.3-0.3-0.6-0.20.8-0.30.0
Intermittent access day 1 total infusions0.10.10.6-0.6-0.60.20.1-0.0-0.00.10.00.1-0.8-0.0-0.0
Intermittent access day 15 total infusions0.40.61.3-1.1-1.10.70.70.60.60.70.50.80.60.6-0.8
Intermittent access terminal intake (last 3 days)0.91.21.9-1.4-1.41.01.00.90.91.00.81.11.01.0-1.3
Intermittent access total infusions0.20.20.8-0.9-0.90.30.40.30.20.40.10.40.10.1-0.4
Intermittent access day 1 locomotion0.10.10.4-0.2-0.2-0.10.20.2-0.2-0.1-0.2-0.2-0.6-0.70.5
Intermittent access day 15 total locomotion0.50.81.6-1.3-1.30.81.11.10.81.00.70.80.50.8-0.6
Intermittent access total locomotion0.30.31.1-1.0-1.00.40.70.60.30.50.20.4-0.20.0-0.1
Intermittent access standard deviation0.51.01.7-0.9-0.91.11.11.10.91.00.91.01.30.6-0.7
Left kidney weight0.31.23.3-1.0-1.00.91.31.31.21.11.30.8-1.80.5-0.2
Right kidney weight0.21.17.6-0.7-0.70.70.90.90.80.70.90.4-2.80.10.2
Cocaine induced anxiety4.36.28.1-2.9-2.92.72.72.72.32.62.82.51.62.0-1.8
Post-drug Anxiety2.72.94.4-2.1-2.11.71.91.91.81.71.81.70.71.3-1.1
Baseline Anxiety1.01.21.91.41.4-1.3-1.1-1.0-0.7-1.1-1.2-1.1-0.8-0.90.8
Tail length1.97.49.2-2.7-2.72.63.03.02.83.02.52.82.72.4-2.4
Length with tail2.310.114.7-3.2-3.23.43.83.83.53.63.13.22.02.2-2.4
Length without tail1.65.28.2-2.4-2.42.52.82.92.62.42.62.2-0.11.4-1.6
Times rat made contact with spout3.74.210.2-1.8-1.81.61.91.91.82.01.91.93.22.3-1.9
Lifetime Intake0.10.10.6-0.8-0.80.10.20.1-0.00.1-0.10.1-0.0-0.1-0.0
Liver weight, left0.10.20.8-0.1-0.10.20.10.10.0-0.1-0.3-0.20.8-0.90.7
Liver weight, right0.91.63.3-1.3-1.31.31.71.81.31.51.21.10.90.8-0.4
Locomotor activity0.20.40.70.80.8-0.6-0.3-0.2-0.5-0.5-0.6-0.7-0.9-0.50.6
Locomotor testing distance1.22.13.01.71.7-1.3-1.1-1.0-1.3-1.4-1.5-1.6-1.1-1.71.6
Locomotor testing rearing0.51.11.51.21.2-1.1-1.0-1.0-1.0-1.1-1.2-1.1-0.0-1.01.0
Locomotion in novel chamber0.60.81.41.11.1-0.9-0.8-0.7-1.2-0.9-0.8-1.0-0.6-0.80.9
Locomotion in novel chamber post-restriction1.72.84.4-1.9-1.91.41.31.21.81.61.41.82.11.8-1.6
Fecal boli incidents, locomotor time 10.40.61.20.60.6-0.9-0.5-0.5-0.9-0.7-0.6-0.8-1.1-0.90.9
Change in fecal boli incidents, locomotor task0.40.43.2-0.3-0.30.40.30.30.30.30.20.51.80.5-0.7
Time >=10cm from walls, locomotor time 10.40.41.20.30.3-0.7-1.0-1.1-0.6-0.7-0.9-0.50.00.00.2
Bouts of movement, locomotor time 10.40.50.90.50.5-0.5-0.9-1.0-0.4-0.8-0.7-0.8-0.5-0.60.8
Total resting periods, locomotor time 10.30.40.70.40.4-0.4-0.8-0.8-0.2-0.7-0.5-0.7-0.1-0.50.8
Rest time, locomotor task time 10.30.41.3-0.5-0.50.40.70.70.50.60.70.41.10.4-0.1
Distance moved, locomotor task time 10.00.10.20.30.30.2-0.2-0.20.0-0.1-0.40.10.4-0.1-0.4
Vertical activity count, locomotor time 10.00.00.10.10.10.1-0.3-0.3-0.2-0.2-0.4-0.1-0.20.1-0.1
Time >=10cm from walls, locomotor time 20.10.11.20.10.1-0.1-0.0-0.0-0.10.10.10.0-1.10.5-0.2
Bouts of movement, locomotor time 20.61.01.70.50.5-1.0-1.1-1.2-0.9-1.1-1.3-1.1-0.1-1.21.3
Total resting periods, locomotor time 20.71.22.00.70.7-1.2-1.2-1.2-1.0-1.2-1.4-1.2-0.2-1.41.4
Rest time, locomotor task time 20.20.32.8-0.2-0.2-0.1-0.0-0.1-0.0-0.1-0.3-0.11.7-0.40.2
Distance moved, locomotor task time 20.10.11.00.50.5-0.0-0.2-0.1-0.2-0.1-0.1-0.1-1.0-0.0-0.2
Vertical activity count, locomotor time 20.40.63.80.60.6-0.5-0.6-0.6-0.6-0.6-0.5-0.6-2.0-0.20.4
Light reinforcement 10.00.10.20.40.4-0.2-0.4-0.4-0.4-0.4-0.4-0.3-0.10.10.2
Light reinforcement 20.20.30.5-0.5-0.50.70.70.70.50.60.50.50.50.6-0.3
Bone: marrow area0.30.70.91.01.0-0.9-1.0-1.0-1.0-0.8-0.9-0.80.0-0.60.6
Bone: maximum diameter1.01.82.9-1.4-1.41.61.71.71.41.51.31.3-0.50.9-0.8
Bone: maximum force2.74.75.9-2.2-2.22.42.22.22.32.32.32.2-2.21.8-1.7
Bone: maximum moment3.66.38.3-2.6-2.62.92.62.62.72.72.72.6-1.82.2-2.0
Mean time between licks in bursts0.61.52.11.21.2-1.2-1.2-1.2-1.2-1.2-1.3-1.3-0.7-1.51.2
Mean num. licks in bursts1.21.93.7-1.2-1.21.11.31.41.31.41.31.31.91.6-1.4
Cd content in liver1.51.72.31.41.4-1.5-1.3-1.3-1.5-1.2-1.4-1.3-1.1-1.01.0
Co content in liver0.10.10.2-0.3-0.30.30.50.50.30.50.30.20.50.20.0
Cu content in liver2.22.73.4-1.7-1.71.81.71.71.71.81.51.61.81.3-1.2
Fe content in liver0.70.81.40.90.9-0.8-1.0-1.0-0.8-0.9-1.0-0.90.1-1.21.0
K content in liver0.10.10.30.00.0-0.3-0.2-0.2-0.3-0.2-0.5-0.20.6-0.60.4
Mg content in liver1.51.52.21.21.2-1.5-1.3-1.3-1.4-1.2-1.5-1.3-0.3-1.11.0
Mn content in liver0.10.11.0-0.1-0.10.0-0.0-0.00.0-0.1-0.0-0.0-1.0-0.20.1
Na content in liver0.40.40.70.40.4-0.5-0.7-0.8-0.6-0.7-0.8-0.60.6-0.80.7
Rb content in liver0.00.00.3-0.1-0.1-0.1-0.1-0.1-0.10.00.10.1-0.60.4-0.2
Se content in liver0.00.00.1-0.2-0.20.10.20.20.10.20.10.20.30.3-0.2
Sr content in liver0.60.50.7-0.8-0.80.80.70.70.70.70.80.70.60.8-0.7
Zn content in liver0.30.40.7-0.6-0.60.40.60.60.50.70.40.60.90.8-0.6
Bone: minimum diameter2.85.17.5-2.4-2.42.62.72.72.52.52.32.20.61.8-1.4
Time in familiar zone, hab. session 10.10.10.3-0.3-0.30.30.30.30.30.30.50.40.00.6-0.4
Time in novel zone, hab. session 10.10.10.20.30.3-0.2-0.4-0.4-0.3-0.3-0.4-0.3-0.4-0.30.3
Total zone transitions, hab. session 10.60.92.20.90.9-0.8-1.0-1.0-0.9-0.9-0.8-0.9-1.5-0.90.6
Total locomotion distance, hab. session 10.20.31.70.40.4-0.3-0.5-0.5-0.5-0.5-0.4-0.5-1.3-0.50.5
Locomotion velocity, hab. session 10.20.31.60.40.4-0.3-0.5-0.6-0.4-0.5-0.4-0.5-1.3-0.50.5
Time in familiar zone, hab. session 20.30.30.60.60.6-0.6-0.7-0.8-0.6-0.6-0.5-0.6-0.5-0.30.5
Time in novel zone, hab. session 20.10.10.30.20.2-0.2-0.1-0.0-0.1-0.1-0.2-0.2-0.6-0.40.1
Total zone transitions, hab. session 22.53.25.11.81.8-1.9-1.8-1.8-1.8-1.7-1.8-1.6-2.3-1.71.3
Total locomotion distance, hab. session 21.21.63.91.31.3-1.3-1.2-1.2-1.2-1.2-1.2-1.1-2.0-1.10.9
Locomotion velocity, hab. session 20.81.13.61.01.0-1.0-1.0-1.0-1.0-0.9-1.0-0.9-1.9-0.90.7
Novel to familiar place preference ratio3.94.35.0-2.2-2.22.22.22.22.22.22.22.10.82.0-1.8
Novelty place preference3.94.25.0-2.2-2.22.22.22.22.22.22.22.10.72.0-1.8
Time in novel zone, NPP test3.03.23.7-1.9-1.91.91.91.91.91.91.91.90.41.7-1.6
Total zone transitions, NPP test3.44.95.52.32.3-2.3-2.3-2.3-2.2-2.2-2.3-2.1-2.2-2.21.8
Total locomotion distance, NPP test2.53.45.11.91.9-1.9-1.9-1.9-1.8-1.8-1.8-1.8-2.3-1.71.5
Locomotion velocity, NPP test1.41.93.31.41.4-1.4-1.4-1.4-1.3-1.4-1.4-1.3-1.8-1.31.1
Intraocular pressure0.10.10.4-0.0-0.00.10.20.20.50.30.40.50.50.6-0.5
Delta distance traveled before/after self-admin0.90.91.60.70.7-1.0-1.2-1.3-1.0-1.1-1.2-1.00.2-0.80.8
Delta ambulatory time before/after self-admin1.92.33.41.41.4-1.7-1.7-1.8-1.6-1.7-1.8-1.60.4-1.41.3
Parametrial fat weight0.10.10.3-0.4-0.40.30.40.40.40.40.20.30.60.4-0.2
Pavlov. Cond. lever latency2.83.54.21.91.9-2.0-2.0-2.0-2.0-1.9-1.9-1.9-1.4-1.61.7
Pavlov. Cond. magazine entry latency3.84.95.8-2.3-2.32.42.12.12.42.32.32.31.62.1-2.1
Pavlov. Cond. change in total contacts2.12.23.0-1.6-1.61.71.51.51.71.51.61.51.01.3-1.1
Pavlov. Cond. index score3.95.05.8-2.4-2.42.42.32.32.42.32.32.31.42.1-2.1
Pavlov. Cond. latency score3.95.05.8-2.3-2.32.42.32.32.42.32.32.31.62.0-2.1
Pavlov. Cond. lever contacts1.41.62.0-1.4-1.41.41.41.41.41.31.31.30.81.0-1.1
Pavlov. Cond. magazine entry number5.67.08.32.82.8-2.8-2.6-2.6-2.9-2.7-2.8-2.8-1.8-2.52.5
Pavlov. Cond. intertrial magazine entries0.30.31.00.60.6-0.7-0.5-0.5-0.6-0.4-0.5-0.5-1.0-0.30.4
Pavlov. Cond. lever-magazine prob. diff.3.84.75.7-2.3-2.32.42.22.22.42.32.22.31.22.0-2.0
Pavlov. Cond. response bias4.04.95.8-2.3-2.32.42.22.22.42.32.32.31.32.1-2.1
Pavlov. Cond. lever latency0.10.10.4-0.4-0.40.40.40.30.40.20.30.20.60.00.2
Pavlov. Cond. magazine entry latency2.93.54.22.12.1-1.9-2.0-2.0-1.9-1.9-1.9-1.9-1.0-2.01.6
Pavlov. Cond. change in total contacts0.71.11.61.21.2-1.1-1.3-1.3-1.1-1.1-1.1-1.0-0.8-0.90.6
Pavlov. Cond. index score0.60.81.11.01.0-1.0-1.0-1.0-0.9-0.9-0.9-0.8-0.6-0.90.6
Pavlov. Cond. latency score0.81.01.41.21.2-1.1-1.1-1.1-1.0-1.0-1.0-1.0-0.7-1.00.7
Pavlov. Cond. lever contacts0.10.20.30.50.5-0.5-0.5-0.5-0.5-0.4-0.5-0.3-0.5-0.1-0.1
Pavlov. Cond. magazine entry number2.02.53.0-1.7-1.71.61.61.61.61.61.71.60.71.7-1.3
Pavlov. Cond. intertrial magazine entries0.40.50.9-0.8-0.80.60.70.70.70.70.80.8-0.41.0-0.8
Pavlov. Cond. lever-magazine prob. diff.0.81.01.31.21.2-1.1-1.1-1.1-1.0-1.0-1.1-1.0-0.6-1.00.7
Pavlov. Cond. response bias0.50.70.91.01.0-0.9-0.9-0.9-0.9-0.8-0.9-0.7-0.7-0.70.3
Time in closed arm before self-admin0.20.31.0-0.8-0.80.60.20.11.00.30.30.50.20.4-0.3
Time in closed arm after self-admin0.20.21.6-0.3-0.3-0.0-0.1-0.10.6-0.0-0.30.11.3-0.4-0.0
Time in open arm before self-admin0.60.71.71.31.3-0.9-0.4-0.2-1.0-0.6-0.5-0.8-0.7-0.70.7
Time in open arm after self-admin0.50.62.80.80.8-0.5-0.5-0.4-0.9-0.5-0.3-0.6-1.7-0.40.6
Bone: periosteal estimation0.71.42.1-1.3-1.31.41.31.31.31.41.21.2-0.80.9-0.7
Bone: periosteal perimeter4.67.810.4-2.8-2.83.23.23.23.03.13.02.91.02.5-2.3
Bone: post-yield work0.30.41.10.80.8-0.7-0.5-0.5-0.6-0.6-0.5-0.6-1.1-0.40.3
Progressive ratio test 1 active lever presses0.20.20.9-0.9-0.90.40.30.20.40.3-0.00.40.10.0-0.3
Progressive ratio test 1 breakpoint0.20.31.1-1.0-1.00.50.40.30.50.40.00.50.10.1-0.4
Progressive ratio test 1 inactive lever presses0.20.30.7-0.8-0.80.60.50.40.40.60.40.6-0.30.5-0.5
Progressive ratio test 2 active lever presses0.20.20.9-1.0-1.00.10.50.40.10.30.20.30.20.2-0.2
Progressive ratio test 2 breakpoint0.20.20.9-1.0-1.00.20.50.40.10.40.30.40.30.2-0.3
Progressive ratio test 2 inactive lever presses0.50.81.7-1.3-1.30.71.11.00.60.90.70.80.30.5-0.6
Incentive Sensitization - Responses0.10.20.7-0.8-0.8-0.00.40.3-0.10.30.30.30.50.4-0.3
Incentive Sensitization - Breakpoint0.20.20.7-0.8-0.8-0.00.40.4-0.00.30.40.30.60.4-0.3
Sum of active levers in priming session hrs 5-62.72.53.6-1.6-1.61.51.61.61.91.61.71.61.31.6-1.6
Progressive ratio0.40.61.40.80.8-0.7-0.7-0.6-0.7-0.7-0.6-0.7-1.2-0.70.8
Food seeking constrained by brief footshock0.50.73.2-0.5-0.50.60.70.80.60.70.80.61.80.9-0.4
Seeking ratio, punishment vs. effort0.00.00.4-0.2-0.20.10.10.10.00.10.10.10.60.30.0
Retroperitoneal fat weight0.62.73.9-2.0-2.01.91.61.52.01.71.61.71.21.5-1.1
Reaction time number correct3.26.28.62.52.5-2.4-2.7-2.7-2.4-2.5-2.5-2.4-2.9-2.21.8
Reaction time mean minus median0.10.31.1-0.6-0.60.60.30.30.40.40.50.41.10.7-0.4
Reaction time mean minus median AUC0.00.00.1-0.1-0.10.2-0.0-0.00.10.10.20.10.40.4-0.3
Reaction time num false alarms0.00.10.20.20.2-0.2-0.3-0.3-0.1-0.3-0.2-0.3-0.50.00.3
Reaction time num false alarms AUC0.30.40.60.70.7-0.7-0.6-0.6-0.5-0.7-0.6-0.7-0.8-0.40.7
Reaction time trials correct on left3.26.28.62.52.5-2.4-2.7-2.7-2.4-2.5-2.5-2.4-2.9-2.21.8
Reaction time trials on left3.46.49.02.62.6-2.4-2.7-2.8-2.5-2.6-2.5-2.4-3.0-2.21.8
Reaction time mean0.10.10.6-0.2-0.20.20.10.10.10.20.20.2-0.40.8-0.3
Reaction time mean AUC0.10.10.60.30.3-0.1-0.3-0.3-0.3-0.2-0.2-0.3-0.80.40.1
Median of all reaction times0.10.11.00.00.00.0-0.0-0.0-0.10.00.0-0.0-1.00.5-0.1
Reaction time omissions0.00.00.20.20.20.00.10.2-0.00.0-0.1-0.1-0.50.00.2
Reaction time false alarm rate0.30.50.6-0.7-0.70.60.80.80.70.60.70.60.80.8-0.3
Reaction time premature initiation rate0.40.61.10.70.7-1.0-0.7-0.7-0.7-0.8-0.6-0.8-0.6-0.90.8
Reaction time premature initiations2.23.84.81.91.9-2.2-2.1-2.1-1.9-2.1-1.9-2.0-1.9-1.91.6
Std. dev. reaction times0.10.30.60.50.5-0.4-0.7-0.8-0.6-0.6-0.5-0.5-0.30.00.3
Reaction time trials completed3.46.49.02.62.6-2.4-2.7-2.8-2.5-2.6-2.5-2.4-3.0-2.21.8
Reaction time trials AUC3.36.39.12.52.5-2.4-2.7-2.7-2.4-2.6-2.5-2.4-3.0-2.21.8
Run reversals in cocaine runway, females1.71.72.91.11.1-1.4-1.6-1.7-1.7-1.5-1.2-1.4-1.0-0.81.2
Run reversals in cocaine runway, males3.43.44.2-1.8-1.81.81.91.91.91.92.01.91.71.8-1.8
Latency to leave start box in cocaine runway0.70.81.41.01.0-0.8-1.0-0.9-0.9-0.9-0.8-0.9-0.2-1.20.8
Latency to leave start box in cocaine runway, F2.02.32.71.61.6-1.6-1.5-1.4-1.6-1.5-1.1-1.6-1.2-1.51.6
Latency to leave start box in cocaine runway, M0.20.21.0-0.4-0.40.40.20.20.50.4-0.00.51.0-0.0-0.6
Std. dev. time between licks in bursts1.92.63.61.71.7-1.6-1.7-1.7-1.7-1.5-1.7-1.5-1.9-1.41.3
Total sessions with >9 infusions0.20.30.5-0.1-0.1-0.3-0.5-0.6-0.6-0.5-0.6-0.5-0.6-0.70.6
Short access day 1 total inactive lever presses0.40.52.00.50.5-0.6-0.00.1-0.6-0.4-0.4-0.7-1.4-0.91.1
Short access day 10 total inactive lever presses0.30.71.2-0.8-0.80.80.91.00.71.10.81.00.10.9-0.7
Short access day 1 total infusions0.91.21.70.70.7-0.9-1.1-1.2-1.2-1.2-1.1-1.2-1.2-1.21.3
Short access day 10 total infusions1.21.62.9-1.7-1.71.21.21.11.11.21.01.21.31.0-1.1
Short access total infusions0.10.10.6-0.8-0.80.10.0-0.1-0.1-0.1-0.2-0.0-0.0-0.20.2
Short access day 1 locomotion0.00.00.2-0.4-0.40.3-0.0-0.10.20.1-0.00.1-0.40.00.0
Short access day 10 total locomotion0.50.91.4-1.0-1.01.01.21.20.81.01.10.90.70.8-0.7
Short access total locomotion0.50.61.0-1.0-1.00.90.90.90.60.80.70.70.40.5-0.5
One hour access (0.3 mA shock)0.10.10.3-0.6-0.60.0-0.0-0.2-0.20.00.00.0-0.20.1-0.1
Compulsive drug intake0.20.20.50.40.4-0.4-0.5-0.6-0.2-0.4-0.4-0.40.7-0.20.3
One hour access (shock baseline)0.00.10.3-0.4-0.4-0.10.10.0-0.3-0.0-0.20.0-0.5-0.3-0.1
Social response proportion0.60.70.90.80.8-0.9-0.8-0.8-0.8-0.8-0.9-0.8-1.0-0.90.7
Social responses0.40.51.60.50.5-0.4-0.5-0.5-0.7-0.6-0.9-0.7-0.7-1.21.0
Social time0.40.53.50.60.6-0.4-0.4-0.3-0.4-0.4-0.5-0.6-1.9-0.60.8
Soleus weight0.51.52.3-1.1-1.11.31.11.11.31.41.31.30.71.5-1.3
Bone: stiffness0.40.76.6-0.3-0.30.50.40.40.40.30.40.3-2.6-0.1-0.0
Tibialis anterior weight0.10.30.60.60.6-0.6-0.7-0.7-0.6-0.5-0.6-0.5-0.8-0.30.3
Time to tail flick, vehicle, before self-admin0.10.10.30.40.4-0.5-0.2-0.2-0.6-0.3-0.1-0.4-0.40.10.4
Time to tail flick, vehicle, after self-admin1.21.62.71.11.1-1.3-1.0-1.0-1.1-1.3-1.2-1.5-0.9-1.71.6
Time to tail flick, test, before self-admin0.10.10.7-0.0-0.0-0.30.10.1-0.10.1-0.20.00.8-0.20.2
Time to tail flick, test, after self-admin0.10.10.3-0.5-0.5-0.10.40.30.10.1-0.1-0.00.5-0.50.3
Delta time to tail flick, vehicle, before/after SA0.40.41.00.60.6-0.6-0.6-0.6-0.4-0.7-0.7-0.7-0.1-1.00.7
Delta time to tail flick, test, before/after SA0.10.10.2-0.4-0.40.40.40.40.30.20.40.2-0.50.0-0.2
Tibia length8.122.328.3-5.0-5.05.35.04.95.15.15.15.00.44.5-4.1
Ambulatory time before self-admin2.13.14.0-1.9-1.92.01.81.81.81.91.91.90.51.7-1.7
Ambulatory time after self-admin0.10.10.4-0.5-0.50.30.1-0.00.10.20.10.30.60.4-0.3
Bone: tissue strength0.40.52.4-0.4-0.40.70.50.60.60.70.60.5-1.50.3-0.1
Total heroin consumption1.31.52.9-1.7-1.71.41.41.41.01.11.41.00.31.0-0.6
Bone: trabecular number0.00.10.3-0.1-0.10.00.10.10.10.10.10.20.60.3-0.3
Bone: trabecular spacing1.51.92.41.41.4-1.4-1.3-1.3-1.4-1.3-1.5-1.3-1.6-1.51.4
Bone: trabecular thickness3.03.74.5-1.9-1.91.91.91.92.01.92.01.91.82.1-1.8
Bone: trabecular tissue density0.71.11.51.01.0-1.0-1.2-1.2-1.0-1.1-1.0-1.1-0.8-0.90.9
Water consumed over 24 hours0.70.93.6-0.8-0.80.80.91.00.80.90.70.81.90.7-0.7
Number of responses in last shaping day0.20.21.00.40.40.00.10.20.0-0.0-0.2-0.2-1.0-0.80.4