Hub : Genes

Lrrc42

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Lrrc42 0.04 0.03 2.5e-03 0.02 0.02 0 0.02 4.8e-03 5.0e-03 1.2e-01 1.8e-02
2 Liver mRNA stability Lrrc42 0.04 0.02 3.8e-04 0.03 0.03 0.02 0.02 6.0e-04 3.8e-04 6.2e-03 1.2e-03
3 PL gene expression Lrrc42 0.2 0.08 0.0e+00 0.21 0.13 0.23 0.11 1.2e-22 8.1e-14 2.2e-24 3.7e-12
4 Eye mRNA stability Lrrc42 0.43 0.17 4.7e-04 0.18 0.12 0.06 0.11 9.9e-04 6.7e-03 3.9e-02 8.4e-03
5 Brain gene expression Lrrc42 0.1 0.06 7.0e-09 0.08 0.1 0.09 0.09 1.0e-07 3.2e-09 4.4e-09 1.1e-08
6 IC gene expression Lrrc42 0.32 0.11 3.1e-12 0.21 0.26 0.23 0.24 4.1e-09 2.1e-11 5.7e-10 1.1e-10
7 Adipose gene expression Lrrc42 0.26 0.1 0.0e+00 0.14 0.12 0.12 0.13 9.0e-15 1.0e-13 1.1e-12 4.5e-14
8 Eye gene expression Lrrc42 0.43 0.17 2.5e-04 0.16 0.15 0.16 0.17 1.8e-03 3.0e-03 2.2e-03 1.2e-03
9 BLA gene expression Lrrc42 0.24 0.1 1.7e-12 0.2 0.22 0.23 0.25 9.7e-11 4.1e-12 1.8e-12 2.6e-13
10 BLA alternative TSS NM_001025653.1 0.05 0.04 9.5e-03 0.02 0.03 0.02 0.01 3.2e-02 1.7e-02 2.6e-02 1.0e-01
11 NAcc gene expression Lrrc42 0.1 0.06 1.4e-08 0.05 0.05 0.05 0.06 2.8e-08 3.2e-08 3.4e-08 6.1e-09
12 PL mRNA stability Lrrc42 0.03 0.02 8.1e-03 0 0 -0 -0 1.5e-01 2.0e-01 1.0e+00 5.0e-01
13 OFC gene expression Lrrc42 0.22 0.12 3.1e-03 0.15 0.09 0.12 0.12 2.6e-04 3.0e-03 7.5e-04 1.0e-03
14 Brain mRNA stability Lrrc42 0.07 0.04 1.3e-06 0.08 0.06 0.07 0.07 3.9e-08 1.2e-06 2.3e-07 2.5e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.71.32.3-1.1-1.1-1.2-0.71.11.50.51.51.2-1.01.21.2-1.21.1
Area under the delay curve0.71.12.10.81.21.4-0.2-1.3-1.2-0.0-1.1-1.30.4-1.2-1.30.7-1.4
BMI with tail0.31.14.3-1.2-0.4-0.32.00.2-0.4-2.1-0.5-0.12.0-0.4-0.60.3-0.5
BMI without tail0.31.54.9-2.2-1.4-1.41.31.21.1-1.41.00.61.00.80.6-1.20.5
Body weight0.31.25.6-2.4-0.6-0.51.80.40.2-1.80.0-0.31.7-0.2-0.6-0.2-0.7
Weight adjusted by age0.10.30.8-0.0-0.4-0.40.50.60.1-0.60.40.90.50.50.4-0.70.5
Bone surface0.10.21.2-1.1-0.5-0.6-0.10.40.80.10.70.4-0.30.20.2-0.20.2
Bone volume0.20.31.0-1.0-0.7-0.70.40.60.8-0.40.60.50.20.30.3-0.30.2
Breakpoint value in progressive ratio session0.00.10.10.40.40.2-0.1-0.3-0.30.3-0.3-0.4-0.2-0.2-0.10.4-0.3
Number of licking bursts0.20.61.00.30.70.6-0.0-0.7-0.8-0.8-1.0-0.70.9-0.9-0.90.9-1.0
Context. condit. distance diff. score1.82.23.6-1.2-1.5-1.8-0.61.61.90.41.71.6-1.01.71.9-1.21.9
Locomotion velocity, session 10.50.51.70.80.60.4-1.2-0.50.01.3-0.1-0.3-1.3-0.30.10.90.2
Locomotion distance, session 10.10.10.20.00.30.30.3-0.3-0.1-0.1-0.1-0.10.1-0.4-0.40.4-0.3
Locomotion velocity, session 20.40.51.51.10.60.6-1.2-0.60.01.1-0.2-0.2-1.1-0.4-0.10.9-0.1
Locomotion distance, session 20.40.51.3-0.70.00.41.1-0.3-0.2-1.1-0.2-0.21.1-0.8-1.10.6-1.0
Locomotion velocity, session 30.10.10.4-0.6-0.0-0.2-0.4-0.00.40.00.10.1-0.2-0.1-0.00.30.0
Locomotion distance, session 30.40.51.1-1.0-0.8-0.90.30.80.7-0.20.70.60.00.80.7-0.70.7
Stereotopy head waving bouts, day 30.91.12.20.61.21.20.3-1.2-1.1-0.5-1.1-1.00.7-1.2-1.50.9-1.4
Stereotopy head waving duration, day 30.50.71.40.41.01.00.1-1.0-0.7-0.2-0.8-0.70.3-0.9-1.20.8-1.1
Locomotion velocity, session 70.60.71.4-0.8-1.2-1.00.31.11.2-0.60.81.20.00.70.9-0.10.8
Locomotion distance, session 72.22.84.6-1.6-2.2-2.10.12.12.0-0.32.02.0-0.41.81.9-1.31.8
Stereotopy head waving bouts, day 71.21.42.80.91.71.3-1.1-1.6-1.00.9-1.0-1.5-0.6-1.2-1.21.0-1.2
Stereotopy head waving duration, day 71.11.32.60.91.61.3-1.1-1.5-1.00.9-1.1-1.5-0.6-1.1-1.11.0-1.0
Locomotion velocity, session 80.30.42.10.30.0-0.2-1.40.10.51.00.50.1-1.10.30.5-0.00.6
Locomotion distance, session 81.11.63.9-2.0-1.5-1.60.21.41.8-0.51.51.4-0.21.11.0-0.81.1
Degree of sensitization distance0.60.71.4-0.5-1.2-1.00.51.11.0-0.50.91.20.00.80.9-0.40.8
Degree of sensitization stereotypy0.80.91.70.61.31.0-0.9-1.3-0.80.6-0.9-1.3-0.4-1.0-1.00.9-1.0
Conditioned locomotion0.10.10.40.20.10.10.6-0.0-0.2-0.4-0.20.20.4-0.2-0.00.40.0
Cocaine response after cond. corrected0.40.51.8-1.3-0.8-0.61.20.70.4-1.20.40.51.00.1-0.10.0-0.1
Cocaine response after cond. not corrected0.60.93.6-1.9-1.1-0.81.40.90.6-1.30.60.61.20.2-0.0-0.1-0.1
Cocaine response before conditioning0.10.20.5-0.7-0.5-0.60.20.50.5-0.20.50.40.10.40.3-0.40.2
Saline control response0.30.40.9-0.9-0.6-0.7-0.40.60.70.61.00.3-0.60.60.6-0.80.2
Bone: connectivity density0.61.01.9-1.1-0.7-0.9-1.10.71.31.01.40.8-1.30.80.9-0.90.8
Bone: cortical apparent density0.81.23.60.5-0.1-0.2-1.70.30.61.81.00.8-1.91.01.1-1.21.0
Bone: cortical area0.50.83.4-1.0-1.0-0.71.80.80.7-1.40.30.51.20.2-0.1-0.30.1
Bone: cortical porosity2.42.64.61.01.91.7-0.1-1.9-1.60.1-1.8-2.00.5-2.0-1.82.2-1.9
Bone: cortical porosity4.34.87.31.82.62.4-0.4-2.7-2.20.5-2.3-2.70.4-2.6-2.42.6-2.5
Bone: cortical thickness0.91.57.1-1.2-0.7-0.42.70.50.0-2.4-0.40.42.2-0.3-0.60.3-0.6
Bone: cortical thickness0.50.72.9-1.1-0.5-0.41.70.40.1-1.4-0.10.51.3-0.2-0.10.6-0.4
Bone: cortical tissue density0.81.33.90.5-0.0-0.2-1.80.30.61.91.00.8-2.01.01.1-1.21.0
Condit. Reinf. active minus inactive responses0.60.71.5-1.2-1.2-1.00.61.11.0-0.60.81.00.30.70.7-0.40.7
Condit. Reinf. active-inactive response ratio1.01.02.1-1.4-1.4-1.20.81.31.2-0.90.91.10.40.80.8-0.50.8
Condit. Reinf. active responses0.30.30.9-0.3-0.10.11.0-0.0-0.3-0.9-0.6-0.21.0-0.4-0.50.8-0.4
Condit. Reinf. inactive responses1.31.62.61.31.41.50.1-1.4-1.6-0.0-1.6-1.30.6-1.4-1.31.6-1.3
Incentive salience index mean0.50.71.9-1.2-1.0-0.81.40.90.6-1.30.30.71.00.30.20.20.2
Condit. Reinf. lever presses0.50.72.7-1.1-0.8-0.71.60.60.4-1.40.00.31.2-0.1-0.10.6-0.2
Condit. Reinf. active minus inactive responses1.92.95.1-2.3-2.1-2.00.42.02.0-0.62.01.70.01.91.4-2.01.4
Condit. Reinf. active-inactive response ratio3.04.77.7-2.7-2.5-2.5-0.12.42.60.12.82.2-0.82.42.1-2.42.1
Condit. Reinf. active responses1.52.14.1-2.0-1.8-1.80.71.71.6-0.91.51.40.41.51.0-1.81.1
Condit. Reinf. inactive responses0.20.31.50.10.00.10.9-0.0-0.4-1.2-0.60.01.1-0.2-0.5-0.1-0.4
Condit. Reinf. lever presses0.20.30.7-0.7-0.5-0.5-0.40.50.60.50.80.3-0.50.70.4-0.90.3
Condit. Reinf. lever reinforcers received1.01.43.0-1.7-1.4-1.40.51.31.3-0.91.21.10.41.20.7-1.50.8
Conditioned reinforcement - actives0.20.91.9-1.4-1.2-1.21.21.10.8-1.00.30.60.70.80.7-0.90.8
Conditioned reinforcement - inactives0.10.20.50.00.60.50.1-0.6-0.6-0.0-0.3-0.60.3-0.5-0.50.2-0.7
Conditioned locomotion1.21.72.6-1.4-1.6-1.50.51.61.4-0.01.51.6-0.31.51.3-1.21.4
Patch foraging indifference point 0 sec0.10.42.4-1.5-0.7-0.80.70.60.6-0.20.60.30.30.30.2-0.50.3
Patch foraging indifference point AUC0.61.52.6-1.2-1.3-1.4-0.31.31.60.31.61.1-0.71.41.2-1.41.1
Delay disc. indifference point, 0s delay0.70.72.21.50.91.0-0.5-0.9-0.90.3-0.9-1.1-0.1-0.8-0.80.6-0.9
Delay disc. indifference point, 16s delay1.01.42.9-0.20.81.11.1-1.0-1.2-1.2-1.3-1.11.5-1.5-1.71.1-1.3
Delay disc. indifference point, 2s delay0.20.21.41.20.40.5-0.3-0.3-0.60.2-0.2-0.3-0.10.2-0.0-0.3-0.5
Delay disc. indifference point, 24s delay0.40.61.30.10.90.9-0.2-1.0-0.8-0.0-0.9-0.90.2-1.0-1.01.1-0.9
Delay disc. indifference point, 4s delay1.11.12.21.51.21.5-0.1-1.2-1.40.1-1.2-1.10.3-0.9-1.10.4-1.2
Delay disc. indifference point, 8s delay0.30.51.5-0.10.60.7-0.1-0.8-0.6-0.2-0.7-0.90.4-0.8-0.90.8-1.2
Indifference point function ln k0.10.20.6-0.40.20.20.8-0.2-0.4-0.6-0.5-0.20.7-0.7-0.40.6-0.5
Indifference point function log k0.10.20.6-0.40.20.20.8-0.2-0.4-0.6-0.5-0.20.7-0.7-0.40.6-0.5
Patch foraging total patch changes 0 sec0.10.42.7-1.6-0.6-0.70.70.50.6-0.10.60.20.20.30.1-0.60.3
Patch foraging total patch changes 12 sec0.30.52.10.20.1-0.1-1.1-0.00.41.40.80.1-1.30.40.3-0.60.3
Patch foraging total patch changes 18 sec0.41.02.0-1.4-1.1-1.10.41.11.0-0.11.41.1-0.11.10.6-1.30.8
Patch foraging total patch changes 24 sec0.10.41.30.00.20.31.1-0.3-0.7-0.8-0.7-0.31.1-0.5-0.60.4-0.7
Patch foraging total patch changes 6 sec0.30.53.3-1.8-0.8-0.90.60.60.8-0.20.80.20.10.40.0-0.60.2
Patch foraging time to switch 0 sec0.72.77.92.82.12.0-1.7-1.8-1.81.7-1.4-1.5-1.1-1.1-0.91.2-0.9
Patch foraging water rate 0 sec0.31.24.2-1.9-1.1-1.02.10.80.6-1.80.10.61.60.1-0.10.0-0.1
Patch foraging water rate 12 sec0.52.16.2-2.4-1.5-1.42.31.20.8-2.50.20.82.10.3-0.1-0.40.3
Patch foraging water rate 18 sec0.20.61.30.60.80.80.2-0.9-0.9-0.4-1.1-0.90.5-0.8-0.90.5-0.6
Patch foraging water rate 24 sec0.10.10.2-0.40.20.10.5-0.2-0.1-0.4-0.3-0.40.4-0.2-0.4-0.2-0.2
Patch foraging water rate 6 sec0.91.32.60.20.40.61.4-0.7-1.0-1.5-1.5-0.91.6-1.2-1.21.4-1.2
Seeking ratio, delayed vs. immediate footshock1.92.75.0-1.6-2.2-1.91.92.11.6-1.91.31.91.11.51.3-0.81.1
Distance traveled before self-admin1.32.95.2-1.9-2.2-2.01.22.12.1-1.41.52.30.51.51.5-1.41.2
Distance traveled after self-admin1.32.35.3-2.3-2.0-1.71.71.71.6-1.91.11.51.11.01.0-1.30.8
Extensor digitorum longus weight0.72.85.8-2.4-1.9-2.02.01.91.4-1.81.21.51.31.51.2-1.51.1
Bone: elastic displacement4.65.810.5-2.2-2.9-2.90.22.92.7-0.52.63.2-0.52.72.8-2.02.7
Bone: elastic work2.43.25.5-2.0-2.3-2.10.52.22.1-0.71.92.3-0.21.91.9-1.31.8
Bone: endosteal estimation0.51.32.3-0.9-1.1-1.3-0.61.11.50.81.50.9-1.11.21.2-1.11.3
Bone: endosteal perimeter0.10.20.70.80.0-0.0-0.7-0.10.30.80.2-0.3-0.70.00.10.00.4
Epididymis fat weight0.21.02.50.81.31.2-0.7-1.3-1.00.5-0.9-1.6-0.2-1.1-1.10.6-0.9
Delta time in closed arm before/after self-admin6.66.212.3-2.2-2.6-2.70.02.82.60.53.22.6-1.22.92.8-3.52.5
Delta time in open arm before/after self-admin1.72.03.51.21.61.6-0.0-1.8-1.70.1-1.8-1.70.4-1.6-1.51.9-1.2
Diff in mean of infusions in LGA sessions0.10.10.5-0.70.20.10.3-0.2-0.2-0.2-0.1-0.20.3-0.4-0.30.5-0.5
Delay discount exponential model param0.91.22.0-0.8-1.3-1.40.31.31.3-0.01.11.3-0.31.11.3-0.61.4
Extinction: sum of active levers before priming0.00.10.30.2-0.1-0.30.20.20.10.10.00.1-0.10.20.5-0.10.4
Active lever presses in extinction session 60.60.62.7-0.5-0.2-0.21.70.1-0.3-1.4-0.5-0.11.4-0.4-0.30.6-0.6
Bone: final force0.00.00.20.4-0.1-0.10.10.10.20.30.30.2-0.30.20.1-0.20.1
Bone: final moment0.00.00.10.2-0.3-0.20.20.20.30.10.30.3-0.10.20.2-0.20.1
Food consumed during 24 hour testing period0.30.61.6-0.20.50.70.4-0.6-0.6-0.5-0.7-1.20.7-0.8-1.10.3-1.3
Glucose0.20.30.7-0.2-0.7-0.60.60.70.5-0.40.30.60.20.50.8-0.40.8
Heart weight0.30.52.6-0.8-0.3-0.21.60.3-0.1-1.1-0.00.41.1-0.2-0.30.1-0.2
Delay discount hyperbolic model param1.01.32.3-1.1-1.3-1.50.31.41.4-0.21.11.4-0.31.11.3-0.61.5
Intermittent access intake day 1-15 change0.10.30.7-0.4-0.6-0.80.50.60.3-0.6-0.2-0.00.40.60.7-0.80.6
Intermittent access intake escalation0.00.20.4-0.3-0.4-0.60.60.30.1-0.6-0.4-0.20.50.40.5-0.60.4
Intermittent access intake escalation 20.10.10.50.20.1-0.10.1-0.2-0.3-0.1-0.7-0.70.20.10.1-0.40.2
Intermitt. access day 1 inactive lever presses0.11.03.0-1.7-1.2-1.01.41.10.8-1.40.70.81.10.40.2-0.50.1
Intermitt. access day 15 inactive lever presses0.00.10.5-0.40.10.20.7-0.2-0.3-0.3-0.2-0.10.6-0.3-0.50.3-0.6
Intermitt. access escalation Index0.00.20.40.20.50.50.1-0.5-0.50.1-0.1-0.30.2-0.5-0.60.3-0.6
Intermittent access day 1 total infusions0.20.61.20.61.11.0-0.1-1.0-0.80.4-0.4-0.7-0.0-1.0-1.00.6-0.9
Intermittent access day 15 total infusions0.10.20.60.30.60.40.4-0.6-0.7-0.2-0.6-0.70.4-0.5-0.40.2-0.5
Intermittent access terminal intake (last 3 days)0.00.10.40.10.1-0.10.1-0.1-0.10.20.0-0.1-0.10.20.2-0.60.3
Intermittent access total infusions0.20.20.50.50.70.6-0.2-0.6-0.60.6-0.2-0.5-0.3-0.3-0.3-0.1-0.3
Intermittent access day 1 locomotion0.20.40.80.40.90.8-0.4-0.8-0.70.8-0.0-0.4-0.3-0.7-0.70.7-0.6
Intermittent access day 15 total locomotion0.00.20.80.90.50.5-0.2-0.4-0.60.5-0.3-0.6-0.2-0.1-0.1-0.1-0.1
Intermittent access total locomotion0.20.20.70.50.70.5-0.3-0.6-0.50.90.1-0.5-0.5-0.2-0.20.1-0.2
Intermittent access standard deviation0.10.62.60.2-0.4-0.31.60.4-0.4-1.5-1.00.11.4-0.10.00.5-0.0
Left kidney weight1.08.427.9-4.2-3.0-2.45.32.61.2-5.00.41.74.31.10.3-1.10.2
Right kidney weight0.64.517.5-3.2-1.8-1.44.21.50.5-3.9-0.10.83.50.3-0.2-0.5-0.3
Cocaine induced anxiety0.10.10.70.1-0.5-0.30.30.40.1-0.50.30.90.40.20.2-0.20.2
Post-drug Anxiety0.20.20.8-0.1-0.20.10.80.2-0.2-0.8-0.10.60.9-0.3-0.30.5-0.3
Baseline Anxiety1.52.44.00.71.51.61.0-1.5-1.6-0.7-1.9-1.71.3-1.9-1.92.0-1.9
Tail length0.10.62.8-1.7-0.8-0.8-0.00.61.2-0.11.10.1-0.10.50.3-1.10.1
Length with tail0.20.74.5-2.1-0.8-0.80.80.60.9-0.80.70.10.60.3-0.0-0.7-0.2
Length without tail0.21.34.8-2.0-0.8-0.52.20.60.1-1.9-0.10.31.9-0.1-0.60.1-0.7
Times rat made contact with spout0.30.31.4-1.2-0.7-0.60.10.50.6-0.70.40.10.50.30.1-0.6-0.1
Lifetime Intake0.20.30.70.50.80.7-0.3-0.7-0.70.7-0.2-0.7-0.3-0.4-0.40.0-0.4
Liver weight, left0.00.10.3-0.2-0.2-0.1-0.10.20.10.00.20.4-0.20.20.4-0.20.6
Liver weight, right0.30.51.1-0.9-0.5-0.6-0.90.50.70.51.10.5-0.80.70.7-0.70.8
Locomotor activity0.71.12.5-0.2-1.3-1.10.11.30.90.11.01.4-0.41.31.6-1.01.5
Locomotor testing distance1.53.65.8-1.3-2.4-2.20.62.41.8-0.01.92.4-0.52.32.4-1.82.3
Locomotor testing rearing0.93.45.3-1.4-2.1-2.10.12.21.80.12.12.0-0.62.22.1-2.32.3
Locomotion in novel chamber1.52.15.7-0.60.10.32.3-0.3-1.0-2.3-1.5-0.82.4-1.1-1.31.6-1.7
Locomotion in novel chamber post-restriction0.10.41.1-0.30.30.30.7-0.4-0.3-1.0-0.8-0.41.0-0.8-0.90.5-0.7
Fecal boli incidents, locomotor time 10.00.10.3-0.50.20.20.1-0.3-0.20.1-0.0-0.50.1-0.4-0.50.5-0.5
Change in fecal boli incidents, locomotor task0.30.30.60.70.70.4-0.6-0.6-0.50.6-0.5-0.8-0.4-0.2-0.30.10.0
Time >=10cm from walls, locomotor time 11.51.83.4-1.5-1.0-1.2-0.71.11.60.91.91.2-1.31.51.4-1.81.6
Bouts of movement, locomotor time 11.11.42.41.01.61.6-0.9-1.5-1.21.0-0.8-1.5-0.5-1.1-1.30.5-1.4
Total resting periods, locomotor time 11.61.93.21.01.81.8-0.8-1.8-1.41.0-1.1-1.8-0.4-1.4-1.51.1-1.5
Rest time, locomotor task time 10.20.30.50.40.60.7-0.5-0.6-0.50.7-0.1-0.3-0.4-0.5-0.50.7-0.5
Distance moved, locomotor task time 10.10.31.0-0.7-0.6-0.80.10.60.8-0.50.30.30.20.70.5-1.00.4
Vertical activity count, locomotor time 10.00.31.0-0.7-0.5-0.50.80.40.2-1.0-0.10.10.80.40.2-0.70.0
Time >=10cm from walls, locomotor time 20.51.54.7-2.2-1.3-1.40.41.31.5-0.21.40.9-0.21.31.0-1.21.1
Bouts of movement, locomotor time 20.10.21.20.70.30.1-0.5-0.2-0.20.2-0.2-0.4-0.20.40.2-1.1-0.2
Total resting periods, locomotor time 20.10.20.90.90.40.3-0.5-0.3-0.30.2-0.3-0.4-0.20.30.1-0.9-0.4
Rest time, locomotor task time 20.91.53.82.01.51.8-0.6-1.4-1.60.7-1.1-1.0-0.2-1.0-1.20.7-1.2
Distance moved, locomotor task time 22.22.98.8-3.0-2.1-2.21.21.92.0-1.41.41.50.71.51.3-1.31.0
Vertical activity count, locomotor time 21.02.45.4-2.3-2.1-2.01.61.91.7-1.71.01.51.01.21.1-0.60.7
Light reinforcement 10.00.10.50.00.00.10.3-0.0-0.3-0.7-0.40.10.7-0.4-0.20.6-0.2
Light reinforcement 20.30.73.1-1.2-0.7-0.51.20.40.3-1.8-0.20.11.5-0.2-0.30.1-0.2
Bone: marrow area0.61.42.5-1.0-1.2-1.4-0.51.21.50.71.61.0-1.01.21.3-1.11.3
Bone: maximum diameter0.10.20.70.20.20.20.8-0.3-0.1-0.6-0.5-0.50.7-0.5-0.70.2-0.4
Bone: maximum force0.20.40.9-0.6-0.8-0.80.30.70.90.10.90.6-0.30.60.5-0.50.5
Bone: maximum moment0.30.51.1-0.8-1.0-0.90.40.81.1-0.11.00.7-0.20.70.5-0.60.5
Mean time between licks in bursts0.10.83.60.4-0.2-0.2-1.90.30.61.50.80.6-1.60.40.70.30.6
Mean num. licks in bursts0.40.91.6-1.2-1.2-1.10.51.21.1-0.11.20.8-0.21.00.9-1.10.9
Cd content in liver3.23.55.8-0.6-1.7-1.8-1.11.92.01.02.22.1-1.62.22.3-2.32.4
Co content in liver3.03.55.7-1.4-2.2-2.2-0.22.22.4-0.02.32.2-0.72.12.0-1.92.0
Cu content in liver3.44.16.3-1.6-2.0-2.0-0.22.12.00.82.42.2-1.42.42.4-2.42.5
Fe content in liver1.01.22.2-1.0-1.5-1.40.91.41.2-1.20.91.30.61.01.0-0.90.9
K content in liver0.10.10.30.1-0.4-0.2-0.20.40.30.20.20.3-0.40.40.5-0.10.5
Mg content in liver0.40.51.20.20.20.51.1-0.3-0.6-0.8-0.8-0.60.9-0.6-0.70.8-0.6
Mn content in liver0.20.30.80.9-0.2-0.2-0.10.30.20.50.10.4-0.60.50.90.00.8
Na content in liver0.60.61.1-0.5-0.9-0.8-0.20.91.00.21.01.1-0.70.91.0-0.30.9
Rb content in liver0.00.00.1-0.1-0.0-0.0-0.10.00.00.20.1-0.0-0.10.1-0.0-0.30.2
Se content in liver1.72.04.3-2.1-1.6-1.7-0.31.61.8-0.21.61.3-0.41.41.4-1.31.3
Sr content in liver0.80.71.1-0.4-1.0-1.00.01.01.0-0.00.91.1-0.31.01.0-0.71.0
Zn content in liver0.20.21.10.60.20.3-0.7-0.1-0.11.10.30.0-1.00.20.3-0.20.2
Bone: minimum diameter0.81.62.9-1.1-1.7-1.50.81.61.6-0.31.41.3-0.01.31.2-1.21.4
Time in familiar zone, hab. session 11.41.62.8-0.9-1.4-1.5-0.11.41.4-0.21.21.7-0.51.51.5-1.11.6
Time in novel zone, hab. session 10.40.41.0-0.5-0.3-0.4-0.70.40.61.01.00.2-0.90.60.6-0.80.5
Total zone transitions, hab. session 10.00.00.1-0.20.20.20.0-0.2-0.10.00.0-0.2-0.00.0-0.2-0.2-0.2
Total locomotion distance, hab. session 10.20.21.2-0.6-0.10.01.1-0.0-0.1-0.8-0.2-0.10.7-0.2-0.40.1-0.3
Locomotion velocity, hab. session 10.60.81.40.20.91.00.8-1.0-0.9-0.5-1.0-1.00.8-1.0-1.20.8-1.1
Time in familiar zone, hab. session 22.02.23.3-1.0-1.7-1.7-0.51.71.80.11.71.7-0.81.71.7-1.61.7
Time in novel zone, hab. session 20.10.10.30.10.50.50.0-0.5-0.50.4-0.2-0.4-0.1-0.3-0.30.3-0.3
Total zone transitions, hab. session 20.10.10.6-0.8-0.4-0.30.40.30.4-0.30.40.20.20.2-0.0-0.30.1
Total locomotion distance, hab. session 20.20.31.4-0.5-0.4-0.21.10.20.1-1.2-0.2-0.01.0-0.2-0.40.3-0.2
Locomotion velocity, hab. session 20.40.52.0-0.4-0.10.11.3-0.1-0.2-1.4-0.6-0.31.3-0.5-0.70.6-0.6
Novel to familiar place preference ratio0.30.30.80.30.30.50.9-0.3-0.8-0.6-0.7-0.40.8-0.4-0.50.3-0.6
Novelty place preference0.20.30.50.40.30.60.7-0.4-0.7-0.4-0.7-0.40.6-0.4-0.50.2-0.6
Time in novel zone, NPP test0.10.10.30.50.20.40.5-0.2-0.6-0.2-0.5-0.20.4-0.2-0.3-0.0-0.4
Total zone transitions, NPP test0.30.41.5-1.1-0.6-0.51.20.50.2-1.10.10.40.90.30.1-0.10.1
Total locomotion distance, NPP test0.40.62.6-1.1-0.6-0.41.60.50.2-1.5-0.20.21.30.0-0.20.0-0.0
Locomotion velocity, NPP test0.60.93.9-1.2-0.6-0.42.00.40.1-1.9-0.40.21.7-0.1-0.40.3-0.2
Intraocular pressure0.61.01.71.01.01.10.4-1.1-1.3-0.1-1.2-1.10.6-0.9-1.20.8-1.2
Delta distance traveled before/after self-admin0.60.61.3-0.40.50.60.7-0.7-0.8-0.9-0.8-1.01.2-0.9-1.00.5-0.8
Delta ambulatory time before/after self-admin0.30.51.20.10.60.60.6-0.7-1.0-0.6-0.8-1.10.9-0.7-0.90.2-0.6
Parametrial fat weight0.30.71.70.10.70.70.4-0.9-0.6-0.5-1.0-1.10.6-1.0-1.00.9-1.3
Pavlov. Cond. lever latency0.60.83.40.70.10.0-1.80.00.31.60.60.2-1.60.40.7-0.60.9
Pavlov. Cond. magazine entry latency0.20.20.90.70.40.4-0.6-0.3-0.20.90.1-0.3-0.8-0.00.1-0.00.0
Pavlov. Cond. change in total contacts0.10.10.30.20.30.20.5-0.3-0.2-0.2-0.3-0.50.3-0.3-0.40.2-0.5
Pavlov. Cond. index score0.10.10.6-0.3-0.00.00.80.0-0.1-0.6-0.1-0.10.5-0.1-0.30.0-0.4
Pavlov. Cond. latency score0.20.20.8-0.20.20.20.9-0.2-0.4-0.7-0.4-0.40.7-0.3-0.60.2-0.7
Pavlov. Cond. lever contacts0.50.62.6-0.5-0.00.11.6-0.1-0.4-1.4-0.6-0.21.3-0.4-0.70.6-0.8
Pavlov. Cond. magazine entry number0.10.20.7-0.8-0.5-0.40.40.30.2-0.70.00.30.50.10.10.10.1
Pavlov. Cond. intertrial magazine entries1.41.62.60.41.11.30.6-1.2-1.6-0.9-1.5-1.21.3-1.5-1.61.4-1.6
Pavlov. Cond. lever-magazine prob. diff.0.10.20.9-0.3-0.1-0.00.90.0-0.2-0.7-0.1-0.10.7-0.1-0.30.1-0.4
Pavlov. Cond. response bias0.00.10.2-0.3-0.3-0.30.40.30.3-0.20.30.20.10.20.1-0.10.0
Pavlov. Cond. lever latency0.00.00.1-0.0-0.1-0.1-0.10.10.2-0.2-0.00.30.1-0.10.10.30.3
Pavlov. Cond. magazine entry latency0.91.22.3-0.0-0.8-0.8-1.20.90.91.21.40.9-1.41.41.2-1.51.2
Pavlov. Cond. change in total contacts0.00.10.10.10.20.3-0.3-0.2-0.20.40.0-0.4-0.2-0.1-0.2-0.1-0.3
Pavlov. Cond. index score0.20.40.80.1-0.3-0.2-0.70.40.30.90.70.3-0.90.80.5-0.90.5
Pavlov. Cond. latency score0.20.30.90.1-0.4-0.3-0.60.40.40.80.70.3-0.70.80.5-1.00.4
Pavlov. Cond. lever contacts0.10.10.3-0.3-0.3-0.2-0.00.30.20.30.40.1-0.20.40.2-0.60.1
Pavlov. Cond. magazine entry number0.60.72.1-0.40.10.11.5-0.2-0.4-1.4-0.9-0.21.4-0.8-0.61.1-0.6
Pavlov. Cond. intertrial magazine entries0.30.71.51.21.11.0-0.4-1.0-1.10.1-1.1-0.70.2-1.0-0.70.9-0.6
Pavlov. Cond. lever-magazine prob. diff.0.30.51.10.1-0.4-0.3-0.80.50.41.00.80.4-1.00.90.7-0.90.6
Pavlov. Cond. response bias0.20.20.70.1-0.2-0.1-0.60.20.20.90.60.1-0.80.50.4-0.70.3
Time in closed arm before self-admin0.71.23.01.71.21.3-0.9-1.2-1.00.5-1.1-1.0-0.2-1.0-0.91.4-0.9
Time in closed arm after self-admin0.30.30.90.1-0.1-0.2-0.80.30.30.80.90.4-0.80.50.6-0.90.5
Time in open arm before self-admin1.51.82.8-1.4-1.6-1.70.71.71.5-0.41.31.4-0.11.51.4-1.61.3
Time in open arm after self-admin0.30.31.2-0.50.20.11.1-0.3-0.4-0.6-0.7-0.60.8-0.5-0.60.6-0.3
Bone: periosteal estimation0.30.81.6-1.3-1.2-1.21.01.01.2-0.61.00.80.30.70.5-0.70.6
Bone: periosteal perimeter0.10.10.3-0.1-0.5-0.40.60.40.5-0.50.20.20.30.1-0.1-0.20.2
Bone: post-yield work0.00.10.20.00.00.0-0.4-0.00.20.50.1-0.3-0.4-0.1-0.00.3-0.2
Progressive ratio test 1 active lever presses0.20.30.7-0.00.50.50.6-0.5-0.6-0.3-0.5-0.70.6-0.8-0.60.8-0.7
Progressive ratio test 1 breakpoint0.20.30.7-0.10.50.40.6-0.5-0.6-0.3-0.5-0.70.6-0.8-0.70.8-0.7
Progressive ratio test 1 inactive lever presses0.10.11.0-1.0-0.2-0.30.60.20.3-0.20.4-0.30.2-0.00.0-0.1-0.1
Progressive ratio test 2 active lever presses0.10.10.3-0.20.20.10.6-0.2-0.3-0.1-0.3-0.40.3-0.3-0.20.3-0.2
Progressive ratio test 2 breakpoint0.10.10.3-0.20.30.20.6-0.3-0.3-0.1-0.4-0.50.3-0.4-0.30.4-0.3
Progressive ratio test 2 inactive lever presses0.10.40.60.50.80.80.2-0.7-0.80.1-0.5-0.80.2-0.7-0.80.3-0.7
Incentive Sensitization - Responses0.30.81.60.91.11.0-0.0-1.1-1.10.2-1.3-1.20.2-1.1-0.90.9-0.9
Incentive Sensitization - Breakpoint0.30.61.20.70.90.80.0-0.9-0.90.2-1.1-1.00.1-0.8-0.70.8-0.7
Sum of active levers in priming session hrs 5-61.11.01.8-0.9-1.2-1.30.71.21.1-0.70.71.30.21.01.2-0.71.3
Progressive ratio0.61.73.21.51.11.31.0-1.2-1.6-0.9-1.8-1.11.3-1.4-1.51.2-1.2
Food seeking constrained by brief footshock1.41.75.1-0.1-0.1-0.6-2.10.31.02.11.30.5-2.31.11.1-1.61.2
Seeking ratio, punishment vs. effort2.35.18.5-1.6-1.4-1.9-2.31.62.42.32.91.7-2.82.42.5-2.72.2
Retroperitoneal fat weight0.41.83.11.71.81.6-0.8-1.7-1.61.1-1.2-1.6-0.4-1.2-1.20.8-1.3
Reaction time number correct0.00.10.5-0.70.0-0.2-0.10.00.20.10.0-0.2-0.20.10.0-0.20.3
Reaction time mean minus median0.10.81.80.81.11.3-0.6-1.1-1.10.7-0.4-0.8-0.2-0.8-1.00.3-1.0
Reaction time mean minus median AUC0.00.10.30.10.50.6-0.5-0.4-0.40.50.1-0.4-0.3-0.2-0.3-0.1-0.3
Reaction time num false alarms0.40.72.0-0.2-0.00.31.3-0.2-0.5-1.3-0.70.01.4-0.8-0.90.9-0.8
Reaction time num false alarms AUC0.40.93.1-0.8-0.40.01.70.1-0.3-1.7-0.60.21.8-0.7-0.90.9-0.9
Reaction time trials correct on left0.00.10.5-0.70.0-0.2-0.10.00.20.10.0-0.2-0.20.10.0-0.20.3
Reaction time trials on left0.00.00.4-0.60.1-0.1-0.2-0.10.10.2-0.0-0.3-0.20.0-0.1-0.20.2
Reaction time mean1.43.15.82.32.32.4-0.8-2.2-2.30.9-1.6-1.7-0.1-1.8-1.81.3-1.7
Reaction time mean AUC0.81.94.02.01.81.9-0.9-1.7-1.81.0-1.1-1.3-0.4-1.2-1.20.7-1.2
Median of all reaction times2.43.76.62.62.42.5-0.9-2.4-2.40.9-1.8-1.9-0.1-2.0-1.91.6-1.8
Reaction time omissions1.52.44.21.21.82.1-0.0-1.9-2.0-0.1-1.5-1.70.7-1.8-2.01.0-1.7
Reaction time false alarm rate0.60.83.0-0.4-0.5-0.01.70.3-0.3-1.7-0.50.41.7-0.5-0.71.0-0.8
Reaction time premature initiation rate0.20.30.70.1-0.4-0.3-0.80.40.50.60.40.4-0.80.50.8-0.10.6
Reaction time premature initiations0.10.41.0-0.3-0.4-0.4-1.00.40.60.80.50.3-1.00.60.8-0.20.8
Std. dev. reaction times0.20.61.40.81.01.2-0.4-1.0-1.10.6-0.4-0.7-0.2-0.7-0.80.2-0.8
Reaction time trials completed0.00.00.4-0.60.1-0.1-0.2-0.10.10.2-0.0-0.3-0.20.0-0.1-0.20.2
Reaction time trials AUC0.00.10.6-0.8-0.0-0.20.00.00.20.00.0-0.2-0.00.1-0.0-0.20.2
Run reversals in cocaine runway, females2.22.54.52.11.82.0-0.4-1.8-1.80.5-1.8-1.80.1-1.5-1.51.7-1.3
Run reversals in cocaine runway, males1.01.11.9-1.3-1.2-1.21.31.20.6-1.40.51.01.10.70.6-1.01.0
Latency to leave start box in cocaine runway0.30.41.3-0.40.20.10.8-0.2-0.4-0.8-0.6-0.41.0-0.6-0.61.1-0.5
Latency to leave start box in cocaine runway, F0.70.92.4-0.60.30.31.4-0.3-0.6-1.4-0.9-0.51.6-0.8-0.91.3-0.6
Latency to leave start box in cocaine runway, M0.10.10.40.40.10.0-0.6-0.1-0.00.60.2-0.1-0.50.10.2-0.1-0.0
Std. dev. time between licks in bursts0.61.23.92.01.01.0-1.9-0.9-0.61.6-0.6-0.6-1.3-0.5-0.11.0-0.3
Total sessions with >9 infusions0.60.71.60.71.21.0-0.5-1.1-1.00.8-0.5-1.2-0.3-0.8-0.70.1-0.7
Short access day 1 total inactive lever presses0.30.62.4-0.6-0.10.01.60.0-0.4-1.4-0.8-0.31.5-0.4-0.60.2-0.6
Short access day 10 total inactive lever presses0.10.83.0-1.7-1.0-0.91.00.80.8-1.00.70.60.70.70.2-1.20.2
Short access day 1 total infusions0.30.61.10.81.01.00.1-0.9-1.00.3-0.8-0.90.1-0.8-0.80.5-0.8
Short access day 10 total infusions0.10.20.40.30.70.60.2-0.6-0.60.2-0.2-0.40.1-0.6-0.50.0-0.4
Short access total infusions0.50.71.40.81.21.0-0.4-1.1-1.00.8-0.5-1.0-0.3-0.9-0.70.3-0.7
Short access day 1 locomotion0.10.10.7-0.4-0.1-0.10.70.1-0.10.00.3-0.10.20.10.0-0.80.1
Short access day 10 total locomotion0.31.12.20.11.11.00.7-1.2-1.2-0.5-1.1-1.11.0-1.3-1.50.9-1.3
Short access total locomotion0.10.10.60.10.40.3-0.5-0.3-0.20.80.3-0.3-0.6-0.0-0.0-0.50.1
One hour access (0.3 mA shock)0.30.30.90.20.0-0.2-0.60.10.11.00.4-0.0-0.90.50.7-0.90.6
Compulsive drug intake0.20.21.20.00.40.3-1.1-0.4-0.00.90.2-0.3-0.7-0.3-0.20.3-0.1
One hour access (shock baseline)0.10.21.0-0.3-0.4-0.31.00.4-0.0-0.60.10.30.60.30.3-0.60.2
Social response proportion0.20.20.70.80.50.5-0.7-0.4-0.40.7-0.1-0.2-0.5-0.2-0.40.0-0.2
Social responses0.30.42.40.7-0.0-0.0-1.50.10.40.80.30.3-1.10.50.6-0.30.7
Social time0.30.41.0-0.6-0.8-0.70.10.80.7-1.00.41.00.60.40.4-0.30.4
Soleus weight1.33.810.4-2.3-2.3-2.03.22.11.2-3.00.71.82.31.21.1-0.71.0
Bone: stiffness0.10.20.50.40.50.50.0-0.5-0.30.3-0.3-0.7-0.0-0.4-0.50.2-0.5
Tibialis anterior weight1.03.513.2-2.8-1.2-1.13.60.90.3-3.6-0.30.33.3-0.1-0.6-0.3-0.8
Time to tail flick, vehicle, before self-admin0.91.12.70.20.50.61.6-0.6-0.9-1.1-1.2-0.81.5-1.0-1.21.4-0.9
Time to tail flick, vehicle, after self-admin0.81.63.11.70.91.10.7-0.9-1.4-1.2-1.7-0.41.4-1.5-1.21.8-1.1
Time to tail flick, test, before self-admin0.30.31.30.2-0.3-0.11.20.2-0.4-1.0-0.50.31.1-0.2-0.10.50.1
Time to tail flick, test, after self-admin0.50.51.9-0.2-0.3-0.11.30.3-0.2-1.4-0.40.51.3-0.3-0.50.7-0.3
Delta time to tail flick, vehicle, before/after SA0.20.20.70.3-0.10.00.30.1-0.2-0.9-0.40.60.7-0.3-0.10.4-0.2
Delta time to tail flick, test, before/after SA0.10.20.50.20.30.40.1-0.4-0.3-0.3-0.4-0.20.2-0.5-0.60.6-0.7
Tibia length0.30.81.60.30.81.00.5-0.9-1.0-0.2-0.9-0.80.6-1.1-1.11.0-1.3
Ambulatory time before self-admin1.23.86.6-2.3-2.6-2.41.02.52.5-1.21.92.50.21.81.8-1.51.5
Ambulatory time after self-admin0.91.53.1-1.7-1.6-1.41.11.41.3-1.21.01.20.70.91.0-1.10.8
Bone: tissue strength1.21.22.3-0.1-1.0-1.0-0.91.01.21.01.20.9-1.31.31.3-1.21.5
Total heroin consumption0.40.41.11.10.80.7-0.6-0.7-0.80.6-0.8-0.7-0.3-0.5-0.20.6-0.4
Bone: trabecular number1.22.23.5-1.3-1.3-1.5-1.11.41.71.01.91.4-1.41.61.7-1.71.6
Bone: trabecular spacing1.42.03.50.81.01.21.7-1.0-1.6-1.6-1.7-1.01.9-1.4-1.61.5-1.6
Bone: trabecular thickness0.70.91.6-0.5-0.9-0.8-0.60.91.10.71.31.1-1.01.11.1-1.01.0
Bone: trabecular tissue density0.00.00.20.30.00.10.10.0-0.0-0.2-0.20.20.10.30.1-0.50.2
Water consumed over 24 hours1.53.07.3-2.7-2.1-2.10.72.02.0-0.72.01.40.11.71.5-2.11.3
Number of responses in last shaping day0.81.03.0-1.3-1.2-1.01.71.10.6-1.30.71.11.20.60.4-0.40.4