Hub : Genes

Lrrc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Lrrc2	0.14	0.11	7.6e-10	0.06	0.07	0.07	0.07	3.0e-07	1.1e-08	5.2e-08	3.2e-08
2	NAcc	alternative TSS	XM_017595598.3	0.02	0.02	5.5e-03	0.01	0.01	0.01	0.01	5.4e-03	3.2e-03	6.2e-03	4.6e-03
3	pVTA	gene expression	Lrrc2	0.04	0.04	1.4e-03	0.02	0.03	0.02	0.02	1.0e-02	3.4e-03	9.7e-03	7.6e-03
4	NAcc	gene expression	Lrrc2	0.06	0.05	3.8e-08	0.05	0.05	0.05	0.05	3.9e-08	4.6e-08	1.2e-07	8.8e-08
5	Brain	gene expression	Lrrc2	0.56	0.2	1.4e-03	0.02	0.03	0.01	0.02	2.2e-03	2.0e-03	2.0e-02	4.2e-03
6	LHb	gene expression	Lrrc2	0.73	0.18	1.8e-03	0.05	0.05	0.1	0.04	2.3e-02	2.5e-02	1.9e-03	3.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.1	-0.0	-0.1	0.1	0.1	0.1	-0.3
Area under the delay curve	1.4	1.6	2.1	1.5	1.4	-1.5	-1.4	-1.0	-0.4
BMI with tail	0.3	0.9	2.8	-0.8	-0.6	0.6	0.5	-1.0	-1.7
BMI without tail	0.4	1.2	2.0	-1.4	-1.2	1.3	1.1	-0.3	-0.9
Body weight	3.8	16.6	25.8	-5.1	-4.8	4.9	4.6	2.2	0.1
Weight adjusted by age	0.0	0.0	0.2	-0.0	-0.0	0.0	0.0	0.1	0.4
Bone surface	0.1	0.2	0.5	0.4	0.4	-0.4	-0.5	-0.7	-0.5
Bone volume	0.0	0.1	0.2	0.2	0.2	-0.2	-0.2	-0.4	-0.3
Breakpoint value in progressive ratio session	0.1	0.2	0.4	0.4	0.4	-0.4	-0.2	-0.2	-0.6
Number of licking bursts	0.1	0.1	0.2	0.5	0.4	-0.4	-0.4	0.0	-0.1
Context. condit. distance diff. score	0.1	0.1	0.6	-0.0	-0.0	0.0	0.0	-0.2	-0.8
Locomotion velocity, session 1	0.1	0.1	0.3	0.2	0.3	-0.2	-0.2	-0.5	-0.3
Locomotion distance, session 1	0.6	0.8	1.3	-1.1	-1.0	1.0	0.9	-0.4	-0.6
Locomotion velocity, session 2	0.6	0.7	1.4	0.5	0.6	-0.6	-0.7	-1.2	-1.1
Locomotion distance, session 2	0.2	0.3	1.4	-0.0	0.1	-0.1	-0.1	-1.2	-0.7
Locomotion velocity, session 3	0.5	0.5	2.0	-0.4	-0.3	0.3	0.1	-1.0	-1.4
Locomotion distance, session 3	1.5	1.6	3.5	0.8	0.9	-0.9	-1.0	-1.7	-1.9
Stereotopy head waving bouts, day 3	0.1	0.1	0.5	-0.1	-0.2	0.2	0.2	0.4	0.7
Stereotopy head waving duration, day 3	0.5	0.6	1.1	-0.5	-0.6	0.6	0.6	1.0	1.1
Locomotion velocity, session 7	0.3	0.3	0.5	-0.7	-0.7	0.7	0.7	0.4	0.1
Locomotion distance, session 7	0.4	0.5	0.8	0.6	0.7	-0.7	-0.6	-0.7	-0.9
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.3	0.3	-0.3	-0.4	-0.2	0.4
Stereotopy head waving duration, day 7	0.1	0.1	0.2	-0.4	-0.4	0.4	0.3	0.1	0.1
Locomotion velocity, session 8	0.6	0.7	2.6	-0.7	-0.5	0.5	0.4	-0.8	-1.6
Locomotion distance, session 8	0.6	0.9	3.2	-0.7	-0.5	0.5	0.4	-1.1	-1.8
Degree of sensitization distance	1.8	1.8	2.6	-1.1	-1.2	1.2	1.4	1.6	1.5
Degree of sensitization stereotypy	0.0	0.0	0.1	0.1	0.1	-0.1	-0.3	-0.1	0.3
Conditioned locomotion	2.5	2.9	4.1	2.0	2.0	-2.0	-2.0	-1.2	-0.1
Cocaine response after cond. corrected	0.2	0.2	0.3	-0.5	-0.5	0.5	0.5	0.5	0.2
Cocaine response after cond. not corrected	1.2	1.4	2.0	-1.4	-1.4	1.4	1.3	0.9	0.4
Cocaine response before conditioning	0.8	0.9	1.5	-1.2	-1.1	1.2	1.1	0.1	-0.3
Saline control response	1.3	1.7	4.3	-0.9	-1.0	1.0	1.1	1.4	2.1
Bone: connectivity density	0.2	0.4	0.6	0.8	0.7	-0.7	-0.7	-0.1	-0.3
Bone: cortical apparent density	0.2	0.3	0.4	0.6	0.6	-0.6	-0.6	-0.6	-0.5
Bone: cortical area	0.1	0.2	0.8	0.4	0.4	-0.3	-0.3	-0.2	0.9
Bone: cortical porosity	0.3	0.3	1.0	0.4	0.3	-0.3	-0.3	0.5	1.0
Bone: cortical porosity	0.3	0.4	1.5	0.3	0.2	-0.2	-0.1	0.8	1.2
Bone: cortical thickness	0.2	0.3	1.2	-0.4	-0.4	0.4	0.4	0.3	1.1
Bone: cortical thickness	0.0	0.0	0.1	-0.0	-0.1	0.1	0.1	0.2	0.4
Bone: cortical tissue density	0.3	0.3	0.4	0.6	0.6	-0.6	-0.6	-0.6	-0.5
Condit. Reinf. active minus inactive responses	0.3	0.3	0.8	-0.3	-0.4	0.4	0.4	0.9	0.7
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.3	-0.5	-0.6	0.6	0.7	1.1	0.9
Condit. Reinf. active responses	0.0	0.0	0.1	0.2	0.1	-0.2	-0.2	0.2	-0.3
Condit. Reinf. inactive responses	0.9	1.1	1.5	0.9	0.9	-1.0	-1.0	-1.1	-1.2
Incentive salience index mean	0.0	0.0	0.1	0.2	0.2	-0.2	-0.2	-0.1	-0.2
Condit. Reinf. lever presses	1.3	1.8	2.2	1.4	1.4	-1.4	-1.4	-1.5	-1.1
Condit. Reinf. active minus inactive responses	1.3	1.6	2.4	-1.6	-1.5	1.5	1.5	0.6	0.7
Condit. Reinf. active-inactive response ratio	1.0	1.1	2.0	-1.4	-1.3	1.3	1.1	0.3	0.3
Condit. Reinf. active responses	1.1	1.5	2.0	-1.4	-1.4	1.4	1.4	0.8	0.8
Condit. Reinf. inactive responses	0.0	0.1	0.1	0.4	0.3	-0.3	-0.1	0.1	-0.0
Condit. Reinf. lever presses	1.6	2.2	3.5	-1.9	-1.8	1.8	1.7	0.6	0.2
Condit. Reinf. lever reinforcers received	1.5	2.0	2.6	-1.6	-1.6	1.6	1.6	1.0	1.0
Conditioned reinforcement - actives	1.0	1.7	2.4	1.6	1.5	-1.5	-1.1	-1.0	-1.0
Conditioned reinforcement - inactives	1.3	1.9	2.6	1.6	1.6	-1.6	-1.4	-1.3	-0.2
Conditioned locomotion	0.2	0.3	0.4	0.6	0.6	-0.6	-0.4	-0.5	0.1
Patch foraging indifference point 0 sec	1.0	1.8	2.3	-1.3	-1.4	1.4	1.4	1.5	0.9
Patch foraging indifference point AUC	0.0	0.0	0.2	-0.2	-0.1	0.1	0.2	-0.1	0.4
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.0	-0.0	0.0	0.1	0.2	0.3
Delay disc. indifference point, 16s delay	0.8	0.9	1.2	1.0	1.1	-1.1	-1.1	-0.9	-0.5
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	0.6	0.6	-0.6	-0.5	-0.4	-0.2
Delay disc. indifference point, 24s delay	0.8	0.9	1.1	1.0	1.0	-1.0	-1.0	-0.8	-0.7
Delay disc. indifference point, 4s delay	1.5	1.6	2.1	1.4	1.4	-1.4	-1.4	-1.1	-0.4
Delay disc. indifference point, 8s delay	1.5	1.7	2.3	1.5	1.5	-1.5	-1.5	-1.0	-0.6
Indifference point function ln k	0.5	0.9	2.5	0.4	0.5	-0.5	-0.7	-1.3	-1.6
Indifference point function log k	0.5	0.9	2.5	0.4	0.5	-0.5	-0.7	-1.3	-1.6
Patch foraging total patch changes 0 sec	1.1	2.1	2.7	-1.4	-1.4	1.5	1.6	1.6	1.1
Patch foraging total patch changes 12 sec	0.9	1.1	1.3	-1.1	-1.1	1.1	1.0	1.0	1.1
Patch foraging total patch changes 18 sec	2.9	4.4	6.0	-1.8	-1.9	1.9	2.3	2.5	2.1
Patch foraging total patch changes 24 sec	1.8	3.0	4.2	-2.0	-1.9	2.0	2.1	1.3	0.9
Patch foraging total patch changes 6 sec	0.2	0.3	0.8	-0.4	-0.4	0.4	0.4	0.6	0.9
Patch foraging time to switch 0 sec	0.1	0.3	0.5	0.7	0.6	-0.6	-0.7	-0.1	-0.3
Patch foraging water rate 0 sec	0.3	0.7	2.0	-0.6	-0.6	0.7	0.9	0.5	1.4
Patch foraging water rate 12 sec	0.2	0.4	0.6	-0.7	-0.7	0.7	0.7	-0.0	0.6
Patch foraging water rate 18 sec	0.1	0.1	0.5	-0.4	-0.3	0.3	0.1	-0.7	-0.1
Patch foraging water rate 24 sec	0.7	0.9	1.1	-1.0	-1.0	1.0	1.0	0.8	0.9
Patch foraging water rate 6 sec	0.4	0.6	0.8	-0.9	-0.8	0.8	0.8	-0.1	0.9
Seeking ratio, delayed vs. immediate footshock	1.4	1.7	2.3	1.5	1.5	-1.5	-1.3	-0.7	1.1
Distance traveled before self-admin	0.1	0.2	0.4	0.5	0.5	-0.5	-0.3	-0.2	-0.6
Distance traveled after self-admin	0.2	0.2	0.4	0.4	0.4	-0.4	-0.4	-0.6	0.5
Extensor digitorum longus weight	0.1	0.6	0.6	0.8	0.8	-0.8	-0.7	-0.7	-0.8
Bone: elastic displacement	0.1	0.1	0.3	-0.2	-0.2	0.2	0.3	0.5	0.4
Bone: elastic work	0.3	0.4	0.6	-0.8	-0.7	0.7	0.7	0.0	-0.2
Bone: endosteal estimation	0.1	0.2	0.3	-0.4	-0.4	0.4	0.5	0.6	0.1
Bone: endosteal perimeter	0.9	2.0	2.5	1.6	1.6	-1.6	-1.5	-1.3	-0.9
Epididymis fat weight	0.3	1.1	1.4	-1.1	-1.1	1.1	1.1	1.2	-0.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.4	0.6	0.6	-0.6	-0.5	-0.4	-0.2
Delta time in open arm before/after self-admin	0.3	0.2	0.4	-0.6	-0.6	0.6	0.5	0.2	0.2
Diff in mean of infusions in LGA sessions	0.0	0.0	0.2	0.0	-0.0	0.0	0.1	0.1	-0.5
Delay discount exponential model param	1.6	1.7	2.3	-1.5	-1.5	1.5	1.5	1.1	0.4
Extinction: sum of active levers before priming	0.0	0.0	0.2	0.1	0.0	-0.0	0.2	0.4	0.1
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.3	-0.4	0.4	0.6	0.7	-0.4
Bone: final force	0.8	1.2	1.8	-1.3	-1.3	1.3	1.3	0.6	0.3
Bone: final moment	0.9	1.5	2.2	-1.5	-1.4	1.5	1.4	0.6	0.3
Food consumed during 24 hour testing period	1.1	1.5	2.1	-1.4	-1.4	1.4	1.4	0.7	0.4
Glucose	0.6	1.0	1.6	-1.3	-1.2	1.2	1.2	0.4	-0.0
Heart weight	1.4	2.2	2.9	-1.7	-1.7	1.7	1.7	1.2	-0.2
Delay discount hyperbolic model param	1.8	2.0	2.7	-1.6	-1.6	1.6	1.6	1.2	0.5
Intermittent access intake day 1-15 change	0.4	0.9	1.1	1.1	1.1	-1.0	-0.9	-0.6	-1.0
Intermittent access intake escalation	0.6	1.3	1.6	1.3	1.3	-1.2	-1.1	-0.8	-1.0
Intermittent access intake escalation 2	0.2	0.2	0.7	0.4	0.3	-0.3	-0.2	-0.2	-0.8
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.2	0.4	0.4	-0.4	-0.5	-0.4	0.4
Intermitt. access day 15 inactive lever presses	0.9	1.9	2.7	1.5	1.5	-1.5	-1.6	-1.3	0.1
Intermitt. access escalation Index	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	-0.0
Intermittent access day 1 total infusions	0.1	0.2	0.3	0.5	0.5	-0.5	-0.4	-0.4	-0.2
Intermittent access day 15 total infusions	1.0	1.5	1.9	1.4	1.4	-1.3	-1.2	-0.9	-1.1
Intermittent access terminal intake (last 3 days)	0.8	1.0	1.3	1.1	1.1	-1.1	-0.9	-0.7	-1.0
Intermittent access total infusions	1.1	1.3	1.8	1.3	1.4	-1.3	-1.1	-0.9	-0.8
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.3	-0.3	0.3	0.3	0.1	0.3
Intermittent access day 15 total locomotion	0.2	0.3	0.5	0.6	0.6	-0.6	-0.5	-0.5	-0.7
Intermittent access total locomotion	0.6	0.7	0.9	1.0	1.0	-0.9	-0.8	-0.7	-0.5
Intermittent access standard deviation	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0	-0.2	-0.1
Left kidney weight	0.5	2.2	3.5	-1.9	-1.8	1.8	1.6	0.7	-0.4
Right kidney weight	0.2	1.1	1.6	-1.3	-1.2	1.2	1.2	0.6	-0.2
Cocaine induced anxiety	0.0	0.0	0.2	-0.1	-0.2	0.1	0.2	0.1	0.4
Post-drug Anxiety	0.0	0.0	0.0	0.2	0.2	-0.2	-0.1	-0.2	0.1
Baseline Anxiety	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3	-0.2	-0.2
Tail length	4.0	15.6	19.9	-4.4	-4.5	4.4	4.3	3.4	2.1
Length with tail	7.1	31.0	41.6	-6.5	-6.4	6.4	6.1	4.5	2.3
Length without tail	6.0	19.3	26.8	-5.2	-5.1	5.1	4.9	3.4	1.3
Times rat made contact with spout	0.3	0.3	0.4	-0.6	-0.6	0.6	0.6	0.6	0.2
Lifetime Intake	1.3	1.5	2.1	1.4	1.5	-1.4	-1.3	-1.0	-0.8
Liver weight, left	0.6	1.0	1.4	-1.0	-1.0	1.0	0.9	0.9	1.2
Liver weight, right	1.3	2.3	2.8	-1.7	-1.7	1.6	1.6	1.1	1.5
Locomotor activity	4.9	7.7	10.5	-3.2	-3.2	3.2	3.2	2.1	0.4
Locomotor testing distance	4.0	7.2	10.0	-3.1	-3.1	3.2	3.2	2.0	0.1
Locomotor testing rearing	0.2	0.4	0.9	-0.5	-0.6	0.6	0.8	1.0	0.3
Locomotion in novel chamber	0.1	0.1	0.2	0.4	0.4	-0.4	-0.3	-0.2	0.3
Locomotion in novel chamber post-restriction	0.4	0.7	1.2	-0.9	-0.9	0.9	1.1	0.7	-0.1
Fecal boli incidents, locomotor time 1	0.3	0.4	0.5	-0.7	-0.7	0.7	0.7	0.6	0.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.0	0.0	-0.0	-0.1	0.0	0.3
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	0.4	0.4	-0.4	-0.5	-0.2	0.6
Bouts of movement, locomotor time 1	0.1	0.2	0.8	-0.2	-0.2	0.2	0.2	0.2	0.9
Total resting periods, locomotor time 1	0.1	0.1	0.6	-0.1	-0.1	0.1	0.1	0.2	0.8
Rest time, locomotor task time 1	0.3	0.4	0.6	0.8	0.8	-0.8	-0.6	-0.2	0.1
Distance moved, locomotor task time 1	0.7	1.1	1.7	-1.3	-1.3	1.3	1.1	0.6	0.2
Vertical activity count, locomotor time 1	0.2	0.5	0.8	-0.9	-0.9	0.9	0.7	0.4	-0.3
Time >=10cm from walls, locomotor time 2	0.8	1.2	1.5	-1.2	-1.2	1.2	1.2	0.9	0.8
Bouts of movement, locomotor time 2	0.0	0.1	0.3	-0.2	-0.2	0.2	0.3	0.1	-0.5
Total resting periods, locomotor time 2	0.0	0.1	0.4	0.0	0.1	-0.0	0.1	-0.1	-0.6
Rest time, locomotor task time 2	0.0	0.0	0.0	0.1	0.1	-0.1	0.0	0.1	0.1
Distance moved, locomotor task time 2	0.5	0.6	0.9	-0.9	-0.9	0.9	0.8	0.5	0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.0	-0.2	-0.2
Light reinforcement 1	0.2	0.6	1.1	-1.0	-1.0	0.9	0.6	0.2	-0.3
Light reinforcement 2	0.5	0.7	1.8	0.3	0.4	-0.4	-0.9	-1.3	-1.1
Bone: marrow area	0.1	0.2	0.3	-0.4	-0.4	0.5	0.5	0.6	0.1
Bone: maximum diameter	0.3	0.6	0.7	0.9	0.9	-0.8	-0.8	-0.7	0.3
Bone: maximum force	0.6	1.1	1.4	-1.2	-1.2	1.2	1.2	0.7	0.6
Bone: maximum moment	0.7	1.2	1.6	-1.3	-1.2	1.2	1.2	0.7	0.6
Mean time between licks in bursts	0.5	1.2	1.7	1.3	1.3	-1.3	-1.2	-1.0	0.0
Mean num. licks in bursts	0.3	0.5	0.7	-0.8	-0.8	0.8	0.7	0.4	0.4
Cd content in liver	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3	-0.3	-0.0
Co content in liver	0.8	0.9	1.4	1.2	1.1	-1.1	-1.1	-0.4	0.6
Cu content in liver	3.1	3.7	5.1	-2.3	-2.2	2.2	2.2	1.5	0.2
Fe content in liver	1.5	1.9	3.5	-1.1	-1.2	1.2	1.3	1.9	1.3
K content in liver	0.4	0.4	1.3	-0.5	-0.4	0.4	0.3	-0.6	-1.2
Mg content in liver	2.0	2.0	4.9	0.8	1.0	-0.9	-1.1	-2.2	-1.9
Mn content in liver	0.5	0.6	1.7	-0.3	-0.1	0.1	-0.1	-1.3	-1.3
Na content in liver	0.9	0.9	2.1	-0.6	-0.7	0.7	0.8	1.5	1.2
Rb content in liver	3.0	3.5	12.3	-0.7	-0.9	0.9	1.1	2.3	3.5
Se content in liver	0.4	0.5	2.5	-0.2	-0.1	0.1	-0.0	-0.6	-1.6
Sr content in liver	2.7	2.3	8.2	-0.1	0.2	-0.1	-0.4	-2.3	-2.9
Zn content in liver	1.6	1.7	2.6	-1.6	-1.6	1.6	1.5	0.7	0.3
Bone: minimum diameter	0.3	0.6	0.8	0.9	0.9	-0.9	-0.8	-0.8	0.3
Time in familiar zone, hab. session 1	1.0	0.9	1.3	1.2	1.0	-1.0	-0.9	0.3	1.1
Time in novel zone, hab. session 1	0.4	0.4	0.5	-0.7	-0.7	0.7	0.6	-0.2	-0.6
Total zone transitions, hab. session 1	0.7	1.0	2.6	-1.1	-0.9	0.9	0.7	-0.7	-1.6
Total locomotion distance, hab. session 1	0.2	0.3	0.8	-0.6	-0.6	0.5	0.4	-0.3	-0.9
Locomotion velocity, hab. session 1	0.3	0.4	0.9	-0.7	-0.6	0.6	0.4	-0.2	-0.9
Time in familiar zone, hab. session 2	0.4	0.5	1.1	0.7	0.7	-0.6	-0.5	-0.2	1.0
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.1	-0.2	0.2	0.2	0.3	-0.3
Total zone transitions, hab. session 2	0.9	1.1	4.9	-0.4	-0.2	0.3	0.1	-1.2	-2.2
Total locomotion distance, hab. session 2	0.4	0.5	1.9	-0.6	-0.5	0.5	0.4	-0.4	-1.4
Locomotion velocity, hab. session 2	0.4	0.6	2.5	-0.5	-0.4	0.4	0.2	-0.6	-1.6
Novel to familiar place preference ratio	0.8	0.8	1.0	-1.0	-1.0	1.0	1.0	0.8	0.6
Novelty place preference	0.8	0.8	1.0	-1.0	-1.0	1.0	1.0	0.8	0.7
Time in novel zone, NPP test	1.1	1.2	1.3	-1.1	-1.1	1.1	1.1	1.1	1.0
Total zone transitions, NPP test	2.1	3.0	4.5	-2.1	-1.8	1.8	1.6	-0.6	-2.1
Total locomotion distance, NPP test	0.8	1.1	1.7	-1.3	-1.1	1.1	0.9	-0.1	-1.3
Locomotion velocity, NPP test	0.9	1.3	2.1	-1.3	-1.2	1.2	0.9	-0.2	-1.5
Intraocular pressure	1.3	1.9	4.2	-1.1	-1.2	1.2	1.3	2.0	1.1
Delta distance traveled before/after self-admin	0.1	0.1	0.7	-0.1	-0.1	0.1	-0.1	-0.3	0.8
Delta ambulatory time before/after self-admin	0.7	0.8	1.1	-1.1	-1.0	1.0	0.7	0.3	1.1
Parametrial fat weight	0.4	0.9	1.7	-1.3	-1.2	1.2	0.9	0.1	-0.2
Pavlov. Cond. lever latency	3.8	4.8	5.7	-2.3	-2.4	2.3	2.4	2.3	1.4
Pavlov. Cond. magazine entry latency	5.9	7.6	9.8	3.1	3.1	-3.1	-3.0	-2.6	-0.9
Pavlov. Cond. change in total contacts	1.1	1.2	1.8	1.3	1.3	-1.3	-1.1	-0.5	0.8
Pavlov. Cond. index score	5.0	6.4	8.2	2.8	2.9	-2.8	-2.8	-2.3	-0.9
Pavlov. Cond. latency score	5.0	6.3	7.9	2.8	2.8	-2.8	-2.8	-2.4	-1.0
Pavlov. Cond. lever contacts	2.5	2.9	3.6	1.7	1.8	-1.8	-1.8	-1.9	-1.1
Pavlov. Cond. magazine entry number	5.8	7.3	9.8	-3.1	-3.1	3.1	3.0	2.3	0.7
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	-0.7	-0.8	0.8	0.8	0.8	0.1
Pavlov. Cond. lever-magazine prob. diff.	4.5	5.6	7.2	2.7	2.7	-2.7	-2.6	-2.2	-1.0
Pavlov. Cond. response bias	5.5	6.9	8.6	2.9	2.9	-2.9	-2.8	-2.5	-1.2
Pavlov. Cond. lever latency	0.6	0.8	1.3	1.2	1.0	-1.1	-1.0	-0.0	0.7
Pavlov. Cond. magazine entry latency	0.5	0.6	2.5	0.2	0.3	-0.3	-0.3	-1.0	-1.6
Pavlov. Cond. change in total contacts	1.8	2.9	4.5	-2.1	-2.0	2.0	2.0	0.9	0.4
Pavlov. Cond. index score	0.4	0.5	1.3	-0.7	-0.6	0.6	0.5	-0.4	-1.1
Pavlov. Cond. latency score	0.3	0.4	1.3	-0.6	-0.4	0.5	0.4	-0.6	-1.2
Pavlov. Cond. lever contacts	0.8	1.1	1.7	-1.3	-1.2	1.2	1.2	0.3	-0.5
Pavlov. Cond. magazine entry number	0.3	0.4	1.3	-0.3	-0.4	0.3	0.3	0.9	1.2
Pavlov. Cond. intertrial magazine entries	0.6	0.9	2.1	1.0	0.9	-0.9	-0.7	0.4	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.6	-0.6	-0.5	0.5	0.4	-0.6	-1.3
Pavlov. Cond. response bias	0.3	0.4	1.2	-0.6	-0.4	0.5	0.4	-0.5	-1.1
Time in closed arm before self-admin	1.0	1.3	2.3	-1.2	-1.2	1.2	1.5	1.1	0.1
Time in closed arm after self-admin	0.1	0.1	0.1	0.4	0.3	-0.3	0.0	-0.1	-0.2
Time in open arm before self-admin	1.0	1.1	1.6	1.2	1.2	-1.2	-1.3	-0.8	0.1
Time in open arm after self-admin	0.2	0.2	0.3	0.4	0.4	-0.4	-0.5	-0.4	0.2
Bone: periosteal estimation	0.0	0.1	0.3	-0.2	-0.2	0.2	0.3	0.2	0.6
Bone: periosteal perimeter	0.7	1.2	1.7	1.3	1.3	-1.3	-1.2	-0.8	-0.0
Bone: post-yield work	0.1	0.2	0.9	-0.1	-0.1	0.1	0.1	-0.1	-1.0
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.1	-0.1	0.1	0.3	0.1	-0.3
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.0	-0.0	0.1	0.2	0.1	-0.3
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.4	0.6	0.6	-0.6	-0.4	-0.5	-0.1
Progressive ratio test 2 active lever presses	1.6	1.8	2.5	1.6	1.6	-1.6	-1.4	-1.2	-0.3
Progressive ratio test 2 breakpoint	1.7	1.9	2.6	1.6	1.6	-1.6	-1.5	-1.2	-0.3
Progressive ratio test 2 inactive lever presses	1.5	2.4	3.4	1.8	1.8	-1.8	-1.5	-1.4	-0.7
Incentive Sensitization - Responses	1.7	2.4	3.2	1.8	1.8	-1.8	-1.8	-1.4	-0.1
Incentive Sensitization - Breakpoint	1.9	2.4	3.2	1.8	1.8	-1.8	-1.8	-1.4	-0.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	0.0	-0.1	0.0	0.1	-0.2
Progressive ratio	2.2	3.4	4.2	-1.9	-1.9	2.0	2.1	1.6	1.5
Food seeking constrained by brief footshock	0.9	1.1	1.4	1.2	1.2	-1.2	-1.1	-0.9	0.6
Seeking ratio, punishment vs. effort	3.7	5.3	6.8	2.6	2.6	-2.6	-2.6	-2.1	-0.7
Retroperitoneal fat weight	1.0	4.5	7.0	-2.6	-2.6	2.5	2.2	1.4	0.1
Reaction time number correct	0.2	0.4	1.1	0.7	0.6	-0.6	-0.5	-0.1	1.1
Reaction time mean minus median	0.1	0.1	0.4	-0.3	-0.2	0.2	0.2	-0.7	-0.4
Reaction time mean minus median AUC	0.1	0.2	0.4	-0.6	-0.5	0.5	0.6	-0.1	0.2
Reaction time num false alarms	0.2	0.2	0.4	0.5	0.5	-0.4	-0.2	0.4	0.7
Reaction time num false alarms AUC	0.1	0.1	0.4	0.3	0.2	-0.2	-0.1	0.5	0.7
Reaction time trials correct on left	0.2	0.4	1.1	0.7	0.6	-0.6	-0.5	-0.1	1.1
Reaction time trials on left	0.2	0.5	1.1	0.7	0.7	-0.7	-0.5	-0.1	1.1
Reaction time mean	0.0	0.1	0.4	-0.1	-0.1	0.1	0.2	0.1	-0.6
Reaction time mean AUC	0.0	0.0	0.1	-0.0	-0.0	0.0	0.1	0.1	-0.3
Median of all reaction times	0.1	0.1	0.3	0.1	0.0	0.0	0.0	0.4	-0.6
Reaction time omissions	0.2	0.3	0.9	0.5	0.4	-0.4	-0.4	0.6	0.9
Reaction time false alarm rate	0.0	0.0	0.2	0.1	0.1	-0.1	-0.0	0.5	0.2
Reaction time premature initiation rate	1.2	1.7	2.6	-1.6	-1.6	1.6	1.3	0.8	0.3
Reaction time premature initiations	0.5	0.8	1.3	-1.1	-1.1	1.1	0.8	0.5	0.7
Std. dev. reaction times	0.1	0.1	0.2	-0.4	-0.4	0.4	0.5	0.1	-0.2
Reaction time trials completed	0.2	0.5	1.1	0.7	0.7	-0.7	-0.5	-0.1	1.1
Reaction time trials AUC	0.3	0.6	1.1	0.8	0.8	-0.8	-0.6	-0.2	1.1
Run reversals in cocaine runway, females	1.1	1.1	1.7	1.2	1.2	-1.2	-1.3	-0.8	-0.6
Run reversals in cocaine runway, males	0.4	0.4	0.7	-0.8	-0.8	0.8	0.4	0.0	0.7
Latency to leave start box in cocaine runway	0.2	0.2	0.6	-0.4	-0.4	0.4	0.1	0.0	0.8
Latency to leave start box in cocaine runway, F	0.5	0.5	0.9	-0.9	-0.9	0.9	0.8	0.4	0.2
Latency to leave start box in cocaine runway, M	0.9	0.8	1.4	1.0	1.0	-1.0	-1.2	-0.7	0.5
Std. dev. time between licks in bursts	2.5	3.4	4.6	2.1	2.1	-2.1	-2.0	-1.6	-0.5
Total sessions with >9 infusions	0.5	0.6	0.8	0.8	0.9	-0.8	-0.9	-0.7	0.0
Short access day 1 total inactive lever presses	2.2	2.9	3.9	2.0	2.0	-1.9	-1.8	-1.4	-0.7
Short access day 10 total inactive lever presses	0.1	0.2	1.0	-0.3	-0.2	0.2	0.1	0.0	1.0
Short access day 1 total infusions	2.3	3.0	4.1	2.0	2.0	-2.0	-2.0	-1.5	-0.1
Short access day 10 total infusions	1.5	1.9	2.6	1.6	1.6	-1.6	-1.5	-1.1	-0.3
Short access total infusions	2.3	3.0	3.9	2.0	2.0	-1.9	-1.9	-1.5	-0.7
Short access day 1 locomotion	0.5	0.7	1.0	0.9	0.9	-0.9	-1.0	-0.7	-0.0
Short access day 10 total locomotion	0.1	0.1	0.4	-0.2	-0.2	0.2	0.2	0.2	0.6
Short access total locomotion	0.0	0.0	0.1	0.2	0.3	-0.2	-0.3	-0.2	0.0
One hour access (0.3 mA shock)	0.2	0.3	0.4	0.7	0.6	-0.6	-0.4	-0.4	0.2
Compulsive drug intake	0.5	0.6	0.9	0.9	0.9	-0.9	-0.9	-0.6	0.3
One hour access (shock baseline)	0.2	0.2	0.3	0.6	0.6	-0.5	-0.3	-0.4	-0.5
Social response proportion	0.2	0.3	0.8	-0.4	-0.4	0.4	0.4	0.5	0.9
Social responses	0.2	0.2	0.4	-0.6	-0.6	0.6	0.5	0.2	0.1
Social time	0.8	1.1	1.7	0.9	0.9	-0.9	-1.3	-1.2	-1.1
Soleus weight	3.1	9.3	13.7	-3.7	-3.6	3.6	3.5	2.0	0.1
Bone: stiffness	0.2	0.4	1.0	-0.5	-0.5	0.5	0.5	0.4	1.0
Tibialis anterior weight	0.1	0.2	1.1	-0.2	-0.2	0.2	0.2	-0.1	-1.1
Time to tail flick, vehicle, before self-admin	1.8	1.9	2.6	-1.4	-1.4	1.4	1.6	1.3	1.1
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	-0.4	-0.4	0.4	0.2	-0.1	-0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.2	0.3	-0.3	-0.5	-0.4	-0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	0.4	-0.4	-0.3	-0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.0	0.7	0.7	-0.7	-0.9	-1.0	-0.4
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.2	0.2	-0.2	0.1	0.3	-0.0
Tibia length	4.8	13.2	20.9	-4.6	-4.3	4.4	4.2	1.5	-0.4
Ambulatory time before self-admin	0.4	0.6	0.9	0.9	0.9	-0.8	-0.6	-0.3	-0.9
Ambulatory time after self-admin	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	-0.3	0.1
Bone: tissue strength	2.8	2.8	3.6	-1.9	-1.9	1.9	1.9	1.4	0.8
Total heroin consumption	1.5	1.8	2.4	-1.6	-1.6	1.6	1.5	1.1	-0.2
Bone: trabecular number	0.5	0.8	1.0	1.0	1.0	-1.0	-0.9	-0.6	-0.7
Bone: trabecular spacing	1.2	1.6	2.0	-1.4	-1.4	1.4	1.3	1.0	1.1
Bone: trabecular thickness	0.2	0.2	1.1	-0.2	-0.1	0.1	0.1	-0.4	-1.0
Bone: trabecular tissue density	0.2	0.3	0.6	-0.8	-0.7	0.7	0.6	-0.1	0.0
Water consumed over 24 hours	0.0	0.0	0.1	-0.2	-0.1	0.1	0.1	-0.2	-0.1
Number of responses in last shaping day	0.1	0.1	0.2	0.4	0.4	-0.4	-0.3	-0.1	-0.3