Hub : Genes

Lpar6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Lpar6	0.05	0.04	4.2e-03	0.02	0.03	0.02	0.02	4.5e-03	4.2e-03	4.5e-03	5.9e-03
2	Adipose	gene expression	Lpar6	0.1	0.06	7.2e-10	0.08	0.08	0.07	0.07	3.4e-09	4.5e-09	2.6e-08	1.2e-08
3	Liver	gene expression	Lpar6	0.03	0.02	6.2e-03	0	-0	-0	-0	2.1e-01	6.8e-01	9.9e-01	6.9e-01
4	Brain	gene expression	Lpar6	0.06	0.05	3.1e-04	0.04	0.03	0.05	0.05	3.3e-04	3.5e-04	3.4e-05	1.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.2	0.3	0.1	0.4	-0.4	-0.6
Area under the delay curve	0.4	0.5	1.3	0.5	0.5	-1.1	0.3
BMI with tail	0.2	0.6	1.6	-0.4	-0.2	0.7	-1.2
BMI without tail	0.7	2.0	4.2	-1.0	-0.6	1.5	-2.1
Body weight	0.1	0.4	1.2	1.1	0.6	-0.5	0.0
Weight adjusted by age	0.8	1.2	4.1	-0.2	-0.3	-0.9	2.0
Bone surface	0.2	0.4	1.1	0.5	0.5	-1.0	-0.0
Bone volume	0.1	0.2	0.8	0.2	0.3	-0.9	-0.3
Breakpoint value in progressive ratio session	0.7	0.8	2.5	-0.9	-1.6	-0.0	0.1
Number of licking bursts	0.3	0.5	1.0	0.2	0.2	0.8	-1.0
Context. condit. distance diff. score	5.0	6.1	12.1	-1.5	-0.5	3.1	-3.5
Locomotion velocity, session 1	0.9	0.9	2.0	-0.5	-0.6	-1.0	1.4
Locomotion distance, session 1	0.8	0.9	2.1	0.7	0.4	-1.4	1.0
Locomotion velocity, session 2	0.9	1.0	1.9	0.6	0.7	-1.1	1.4
Locomotion distance, session 2	2.0	2.8	6.2	1.2	0.5	-2.5	1.8
Locomotion velocity, session 3	0.6	0.7	1.1	-0.7	-0.4	1.0	-1.1
Locomotion distance, session 3	1.2	1.3	3.0	-0.5	-0.1	1.4	-1.7
Stereotopy head waving bouts, day 3	0.5	0.6	1.1	-0.5	-1.0	-0.3	1.0
Stereotopy head waving duration, day 3	0.7	0.9	1.8	-0.4	-0.9	-0.9	1.3
Locomotion velocity, session 7	7.9	8.7	19.0	-1.0	0.3	3.8	-4.4
Locomotion distance, session 7	6.1	7.7	17.9	-1.2	-0.5	3.3	-4.2
Stereotopy head waving bouts, day 7	1.0	1.2	2.4	0.7	0.6	-1.1	1.5
Stereotopy head waving duration, day 7	1.0	1.2	3.3	0.4	0.3	-1.0	1.8
Locomotion velocity, session 8	0.4	0.5	1.2	-0.4	-0.1	0.8	-1.1
Locomotion distance, session 8	0.6	0.8	2.7	0.2	0.5	0.5	-1.6
Degree of sensitization distance	2.5	2.5	5.3	-0.9	-0.4	2.0	-2.3
Degree of sensitization stereotypy	0.7	0.8	1.4	0.7	0.8	-0.8	1.2
Conditioned locomotion	0.7	0.8	1.3	-0.8	-0.5	1.1	-0.9
Cocaine response after cond. corrected	2.1	2.6	3.9	-2.0	-1.9	1.5	-0.8
Cocaine response after cond. not corrected	0.9	1.0	1.6	-1.3	-0.9	1.0	-0.7
Cocaine response before conditioning	2.5	3.0	5.9	2.1	2.4	-1.2	0.4
Saline control response	0.6	0.8	1.9	1.4	0.6	-0.9	0.4
Bone: connectivity density	0.3	0.4	0.9	0.8	1.0	-0.1	-0.4
Bone: cortical apparent density	1.1	1.5	2.7	-1.0	-1.2	1.6	-0.8
Bone: cortical area	0.1	0.1	0.2	0.3	0.2	-0.5	-0.1
Bone: cortical porosity	2.1	2.3	3.0	1.7	1.7	-1.6	0.8
Bone: cortical porosity	1.8	2.0	3.0	1.6	1.4	-1.7	0.8
Bone: cortical thickness	0.1	0.2	0.4	0.6	0.5	0.1	-0.2
Bone: cortical thickness	0.8	0.9	1.5	-0.8	-0.6	1.2	-1.1
Bone: cortical tissue density	1.2	1.6	3.0	-1.1	-1.2	1.7	-0.9
Condit. Reinf. active minus inactive responses	1.8	2.0	2.9	1.6	1.0	-1.3	1.7
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	-0.3	-0.7	-0.1	0.8
Condit. Reinf. active responses	3.0	3.7	5.9	2.4	2.0	-1.5	1.6
Condit. Reinf. inactive responses	3.9	4.8	8.2	2.9	2.7	-1.6	0.9
Incentive salience index mean	4.7	5.8	9.4	3.1	2.6	-1.9	1.9
Condit. Reinf. lever presses	5.7	7.9	14.6	3.8	3.4	-1.8	1.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.7	0.6	0.8	0.3	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.0	0.5	0.4	-0.3
Condit. Reinf. active responses	0.3	0.4	0.9	0.7	0.9	0.3	-0.4
Condit. Reinf. inactive responses	0.4	0.5	1.1	1.0	0.8	0.0	-0.6
Condit. Reinf. lever presses	1.6	2.3	3.6	1.9	1.9	-1.3	0.6
Condit. Reinf. lever reinforcers received	0.4	0.6	1.3	1.0	1.2	0.1	-0.4
Conditioned reinforcement - actives	0.6	1.0	1.5	-0.9	-0.7	1.2	-1.1
Conditioned reinforcement - inactives	1.5	2.2	4.2	2.0	2.0	-0.8	-0.2
Conditioned locomotion	0.1	0.2	0.3	-0.5	-0.4	-0.4	-0.3
Patch foraging indifference point 0 sec	3.1	5.7	10.8	3.2	3.3	-1.3	0.5
Patch foraging indifference point AUC	1.3	1.9	3.8	-1.9	-1.4	1.1	-1.0
Delay disc. indifference point, 0s delay	1.8	2.0	3.2	1.1	0.8	-1.7	1.8
Delay disc. indifference point, 16s delay	0.2	0.2	0.7	0.2	0.1	-0.8	0.2
Delay disc. indifference point, 2s delay	0.7	0.8	1.5	-0.3	-0.2	-1.2	1.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	-0.6	-0.3	0.2	-0.5
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.3	-0.2	-0.6	0.7
Delay disc. indifference point, 8s delay	0.3	0.4	0.6	0.8	0.7	-0.4	-0.5
Indifference point function ln k	1.2	2.1	4.5	2.1	1.6	-1.0	0.5
Indifference point function log k	1.2	2.1	4.5	2.1	1.6	-1.0	0.5
Patch foraging total patch changes 0 sec	2.8	5.3	9.8	3.1	3.1	-1.3	0.6
Patch foraging total patch changes 12 sec	0.9	1.2	1.8	1.3	1.3	-1.0	0.3
Patch foraging total patch changes 18 sec	0.2	0.4	1.0	0.3	0.2	0.6	-1.0
Patch foraging total patch changes 24 sec	0.7	1.3	2.3	1.5	1.4	-0.9	0.2
Patch foraging total patch changes 6 sec	0.8	1.2	2.0	1.0	1.4	0.9	-1.1
Patch foraging time to switch 0 sec	0.0	0.1	0.2	0.3	0.0	-0.3	0.4
Patch foraging water rate 0 sec	0.2	0.4	0.8	0.8	0.9	-0.2	-0.1
Patch foraging water rate 12 sec	0.0	0.1	0.2	0.3	-0.0	0.1	0.5
Patch foraging water rate 18 sec	0.3	0.4	0.9	-0.6	-0.2	0.9	-0.6
Patch foraging water rate 24 sec	0.7	0.9	2.0	-0.4	-0.5	1.4	-1.2
Patch foraging water rate 6 sec	0.2	0.3	0.5	-0.1	-0.6	-0.7	0.7
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.2	0.8	0.6	-0.5	1.1
Distance traveled before self-admin	1.0	1.2	2.2	-0.3	-1.1	-1.5	1.2
Distance traveled after self-admin	1.7	2.0	4.8	-1.8	-2.2	0.1	-0.1
Extensor digitorum longus weight	2.7	10.7	19.8	-3.4	-4.5	-1.8	2.8
Bone: elastic displacement	0.9	1.0	2.1	0.8	0.0	-1.3	1.4
Bone: elastic work	1.8	2.3	4.8	1.2	0.5	-2.2	1.7
Bone: endosteal estimation	0.1	0.2	0.8	0.1	-0.0	-0.9	-0.0
Bone: endosteal perimeter	0.2	0.3	1.1	0.0	0.1	-1.0	0.5
Epididymis fat weight	0.3	1.1	2.4	1.4	1.6	-0.2	-0.2
Delta time in closed arm before/after self-admin	0.8	0.7	1.8	0.7	1.3	-0.3	-0.6
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.3	-0.4	-0.1	-0.3
Diff in mean of infusions in LGA sessions	0.3	0.4	0.7	-0.4	-0.8	-0.2	0.8
Delay discount exponential model param	0.4	0.4	1.3	-0.4	-0.4	1.1	-0.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.5	0.4	-0.3	-0.2
Active lever presses in extinction session 6	0.5	0.5	1.4	-0.1	0.1	0.7	-1.2
Bone: final force	0.7	1.1	2.1	1.5	1.3	-0.4	-0.4
Bone: final moment	0.8	1.3	2.6	1.6	1.3	-0.9	-0.0
Food consumed during 24 hour testing period	0.3	0.4	0.6	0.7	0.6	-0.8	-0.3
Glucose	1.8	2.8	4.1	-1.7	-1.5	1.4	-2.0
Heart weight	0.1	0.1	0.3	0.2	0.5	-0.2	-0.2
Delay discount hyperbolic model param	0.3	0.4	1.2	-0.3	-0.3	1.1	-0.3
Intermittent access intake day 1-15 change	0.6	1.2	1.6	1.1	1.3	0.8	-1.1
Intermittent access intake escalation	0.7	1.5	2.8	1.5	1.7	0.6	-0.9
Intermittent access intake escalation 2	0.7	0.8	1.7	0.3	0.6	1.1	-1.3
Intermitt. access day 1 inactive lever presses	0.1	0.4	1.0	0.5	0.4	1.0	-0.4
Intermitt. access day 15 inactive lever presses	0.3	0.7	1.5	1.2	1.0	-0.1	-0.3
Intermitt. access escalation Index	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.3
Intermittent access day 1 total infusions	0.2	0.3	0.5	0.7	0.5	-0.3	-0.5
Intermittent access day 15 total infusions	1.0	1.6	3.0	1.6	1.7	0.1	-0.7
Intermittent access terminal intake (last 3 days)	0.6	0.9	1.6	0.7	0.9	0.7	-1.3
Intermittent access total infusions	0.8	1.0	1.3	1.1	1.1	0.4	-1.1
Intermittent access day 1 locomotion	0.9	1.1	2.5	1.6	1.4	-0.4	-0.3
Intermittent access day 15 total locomotion	0.2	0.4	1.0	0.1	-0.0	0.8	-1.0
Intermittent access total locomotion	0.4	0.4	1.0	1.0	0.7	0.0	-0.6
Intermittent access standard deviation	0.1	0.1	0.4	-0.3	-0.6	-0.1	-0.2
Left kidney weight	1.1	5.1	9.2	2.9	3.0	-1.6	0.3
Right kidney weight	1.7	7.7	11.3	3.4	3.1	-2.8	1.5
Cocaine induced anxiety	2.6	3.7	5.9	1.6	0.9	-2.4	2.4
Post-drug Anxiety	2.5	2.6	3.5	1.9	1.4	-1.5	1.8
Baseline Anxiety	1.2	1.4	3.0	-0.1	0.5	1.5	-1.7
Tail length	0.2	0.7	1.6	1.3	1.1	-0.4	0.0
Length with tail	0.6	2.6	3.8	2.0	1.0	-1.6	1.7
Length without tail	0.7	2.1	5.3	0.8	-0.2	-1.6	2.3
Times rat made contact with spout	1.5	1.7	4.6	0.6	0.8	1.0	-2.2
Lifetime Intake	0.6	0.7	1.2	0.8	0.8	0.3	-1.1
Liver weight, left	2.9	4.8	9.2	1.6	0.7	-2.6	3.0
Liver weight, right	0.5	0.9	2.6	-0.9	-1.6	-0.4	-0.1
Locomotor activity	6.5	10.2	18.9	1.7	0.7	-4.3	4.3
Locomotor testing distance	5.2	9.3	15.3	2.4	1.4	-3.9	3.8
Locomotor testing rearing	5.3	10.8	16.5	2.9	1.9	-4.1	3.8
Locomotion in novel chamber	0.5	0.6	0.9	0.8	0.9	-0.9	-0.3
Locomotion in novel chamber post-restriction	0.3	0.6	1.1	-1.0	-0.9	0.1	-0.6
Fecal boli incidents, locomotor time 1	0.5	0.7	2.0	0.5	0.1	-1.4	0.6
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	-0.6	-0.8	0.3	0.2
Time >=10cm from walls, locomotor time 1	1.1	1.2	2.0	1.4	1.4	-0.8	0.6
Bouts of movement, locomotor time 1	0.4	0.5	0.9	-0.9	-0.7	0.5	0.7
Total resting periods, locomotor time 1	0.7	0.8	1.5	-1.2	-1.0	0.6	0.4
Rest time, locomotor task time 1	0.6	0.8	1.7	-1.3	-1.2	-0.1	0.1
Distance moved, locomotor task time 1	0.5	0.8	1.4	1.0	1.2	0.8	-0.3
Vertical activity count, locomotor time 1	0.1	0.3	0.8	0.4	-0.1	-0.6	0.9
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.0	-0.6	-1.0	-0.8	0.8
Bouts of movement, locomotor time 2	0.8	1.2	2.4	-1.5	-1.5	0.5	0.4
Total resting periods, locomotor time 2	0.6	1.0	2.0	-1.4	-1.4	0.4	0.3
Rest time, locomotor task time 2	0.7	0.9	1.5	-1.2	-1.2	0.2	-0.7
Distance moved, locomotor task time 2	0.9	1.1	2.1	1.4	1.4	-0.2	0.5
Vertical activity count, locomotor time 2	0.3	0.5	0.9	-0.1	-0.5	-0.8	0.9
Light reinforcement 1	0.7	1.8	3.6	0.7	1.3	1.2	-1.9
Light reinforcement 2	2.8	4.3	8.5	-1.2	-0.3	2.7	-2.9
Bone: marrow area	0.1	0.2	0.9	0.2	0.1	-0.9	-0.0
Bone: maximum diameter	0.2	0.4	1.0	-1.0	-0.6	0.2	-0.4
Bone: maximum force	0.5	0.8	1.4	1.2	0.8	-1.1	0.1
Bone: maximum moment	0.8	1.3	2.5	1.4	0.9	-1.6	0.5
Mean time between licks in bursts	0.1	0.2	0.9	0.1	0.1	0.3	-0.9
Mean num. licks in bursts	0.1	0.1	0.3	0.1	0.1	-0.0	-0.5
Cd content in liver	1.1	1.2	2.1	0.1	-1.1	-1.5	1.3
Co content in liver	3.7	4.3	9.0	-2.7	-3.0	0.8	-0.6
Cu content in liver	0.4	0.5	0.9	-0.7	-1.0	0.5	-0.5
Fe content in liver	0.2	0.2	0.5	0.6	0.7	0.3	-0.2
K content in liver	1.2	1.1	1.7	0.6	1.3	1.1	-1.2
Mg content in liver	0.5	0.5	1.3	-0.0	0.4	0.8	-1.1
Mn content in liver	0.5	0.5	0.7	-0.8	-0.7	0.5	-0.8
Na content in liver	4.1	4.4	6.0	1.8	1.6	-2.5	2.4
Rb content in liver	0.1	0.1	0.3	-0.0	-0.2	0.5	0.2
Se content in liver	2.3	2.7	5.3	0.8	0.2	-2.2	2.3
Sr content in liver	0.6	0.5	1.2	-0.7	-1.1	-0.6	0.0
Zn content in liver	0.3	0.3	0.8	0.3	-0.2	-0.9	0.5
Bone: minimum diameter	0.3	0.5	1.5	0.6	0.2	-1.2	0.4
Time in familiar zone, hab. session 1	0.6	0.6	1.6	0.2	0.6	0.6	-1.3
Time in novel zone, hab. session 1	2.7	2.7	5.5	-2.1	-2.3	0.5	0.8
Total zone transitions, hab. session 1	0.3	0.4	1.0	0.1	-0.3	-1.0	0.8
Total locomotion distance, hab. session 1	1.2	1.7	2.7	1.0	0.8	-1.6	1.5
Locomotion velocity, hab. session 1	2.6	3.6	5.6	1.8	1.5	-2.4	1.8
Time in familiar zone, hab. session 2	1.2	1.3	2.3	-1.5	-1.4	0.7	-0.6
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.4	0.3	-0.4	0.6
Total zone transitions, hab. session 2	1.9	2.5	4.8	0.7	-0.1	-2.1	2.2
Total locomotion distance, hab. session 2	1.4	1.8	3.6	0.8	0.1	-1.8	1.9
Locomotion velocity, hab. session 2	1.9	2.5	4.8	0.8	0.1	-2.2	2.2
Novel to familiar place preference ratio	0.5	0.5	1.4	1.2	0.7	-0.3	0.1
Novelty place preference	0.6	0.6	1.7	1.3	0.9	-0.4	0.2
Time in novel zone, NPP test	0.4	0.4	1.1	1.0	0.7	-0.3	0.2
Total zone transitions, NPP test	0.8	1.1	1.6	1.0	0.7	-1.3	1.1
Total locomotion distance, NPP test	1.2	1.6	2.4	1.5	1.3	-1.2	0.9
Locomotion velocity, NPP test	1.3	1.8	3.0	1.7	1.4	-1.2	0.8
Intraocular pressure	0.1	0.2	0.3	0.6	0.4	0.4	-0.4
Delta distance traveled before/after self-admin	2.9	3.1	4.2	-2.0	-1.8	1.8	-1.4
Delta ambulatory time before/after self-admin	1.4	1.7	2.2	-1.5	-1.5	1.2	-1.0
Parametrial fat weight	0.4	1.0	1.2	1.1	1.1	0.7	-1.0
Pavlov. Cond. lever latency	2.0	2.5	5.2	-2.3	-2.0	0.7	-0.4
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	0.9	0.9	0.3	-0.5
Pavlov. Cond. change in total contacts	1.3	1.4	3.1	1.8	1.1	-0.9	0.7
Pavlov. Cond. index score	1.8	2.2	4.8	2.2	2.0	-0.5	0.0
Pavlov. Cond. latency score	2.2	2.8	5.9	2.4	2.2	-0.5	0.0
Pavlov. Cond. lever contacts	2.4	2.9	5.9	2.4	2.3	-0.5	0.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	-0.7	-0.6	0.1	0.3
Pavlov. Cond. intertrial magazine entries	1.9	2.3	3.3	1.8	1.7	-1.3	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.6	1.9	4.1	2.0	1.8	-0.6	0.0
Pavlov. Cond. response bias	0.5	0.6	1.4	1.2	1.0	-0.2	-0.1
Pavlov. Cond. lever latency	2.0	2.7	4.4	-1.6	-1.3	2.1	-1.5
Pavlov. Cond. magazine entry latency	1.3	1.6	3.0	1.3	1.2	-1.7	0.4
Pavlov. Cond. change in total contacts	0.8	1.3	2.8	0.3	-0.4	-1.7	1.5
Pavlov. Cond. index score	1.8	2.4	5.0	1.3	0.9	-2.2	1.3
Pavlov. Cond. latency score	2.0	2.7	5.2	1.5	1.1	-2.3	1.4
Pavlov. Cond. lever contacts	1.9	2.7	4.7	1.6	1.3	-2.2	1.4
Pavlov. Cond. magazine entry number	0.6	0.8	1.5	-1.0	-0.8	1.2	0.0
Pavlov. Cond. intertrial magazine entries	1.6	2.4	3.6	1.1	1.7	1.3	-1.9
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.9	4.0	1.2	0.9	-2.0	1.2
Pavlov. Cond. response bias	1.9	2.6	5.4	1.5	1.0	-2.3	1.2
Time in closed arm before self-admin	0.1	0.1	0.2	-0.3	-0.1	0.5	-0.2
Time in closed arm after self-admin	0.1	0.1	0.1	0.2	0.3	0.2	-0.4
Time in open arm before self-admin	0.2	0.2	0.4	-0.3	-0.4	-0.3	0.7
Time in open arm after self-admin	0.1	0.1	0.3	-0.5	-0.5	-0.2	-0.1
Bone: periosteal estimation	0.1	0.1	0.5	0.0	-0.0	-0.7	-0.1
Bone: periosteal perimeter	0.0	0.1	0.2	-0.2	-0.3	-0.4	-0.1
Bone: post-yield work	1.1	1.6	4.7	-0.7	-0.4	1.1	-2.2
Progressive ratio test 1 active lever presses	0.8	1.0	2.2	-0.5	-0.7	1.0	-1.5
Progressive ratio test 1 breakpoint	0.9	1.0	2.1	-0.6	-0.8	1.0	-1.5
Progressive ratio test 1 inactive lever presses	1.0	1.4	2.6	0.4	0.3	1.6	-1.6
Progressive ratio test 2 active lever presses	1.1	1.2	3.4	-0.4	-0.2	1.2	-1.8
Progressive ratio test 2 breakpoint	0.9	1.0	2.9	-0.3	-0.1	1.0	-1.7
Progressive ratio test 2 inactive lever presses	0.4	0.6	1.4	0.8	0.5	0.5	-1.2
Incentive Sensitization - Responses	0.4	0.5	1.6	-0.1	0.5	0.5	-1.3
Incentive Sensitization - Breakpoint	0.4	0.5	1.5	0.1	0.6	0.5	-1.2
Sum of active levers in priming session hrs 5-6	1.9	1.7	3.5	-1.9	-1.2	1.4	-0.2
Progressive ratio	1.1	1.7	2.2	-1.4	-1.5	1.2	-1.1
Food seeking constrained by brief footshock	7.6	9.3	16.3	-3.7	-4.0	2.4	-1.0
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	-0.8	-0.6	0.2	0.5
Retroperitoneal fat weight	0.3	1.2	2.0	1.2	1.4	0.9	-0.8
Reaction time number correct	1.7	3.3	5.1	-2.3	-2.2	1.4	-1.0
Reaction time mean minus median	1.4	3.4	6.0	1.5	0.9	-2.1	2.5
Reaction time mean minus median AUC	0.4	1.1	1.4	1.0	0.9	-1.1	1.2
Reaction time num false alarms	0.1	0.1	0.2	0.1	0.5	-0.3	-0.1
Reaction time num false alarms AUC	0.1	0.1	0.4	0.0	0.6	-0.1	-0.4
Reaction time trials correct on left	1.7	3.3	5.1	-2.3	-2.2	1.4	-1.0
Reaction time trials on left	1.7	3.2	4.9	-2.2	-2.1	1.5	-1.0
Reaction time mean	1.5	2.3	4.1	1.2	1.0	-1.7	2.0
Reaction time mean AUC	1.6	2.6	5.1	1.1	0.8	-1.8	2.3
Median of all reaction times	0.8	1.2	2.3	0.7	0.8	-1.2	1.5
Reaction time omissions	0.3	0.4	0.7	0.8	0.8	-0.4	0.6
Reaction time false alarm rate	0.6	0.9	2.3	1.0	1.5	-0.5	-0.1
Reaction time premature initiation rate	0.4	0.5	0.9	-0.7	-0.9	0.9	0.1
Reaction time premature initiations	1.5	2.8	4.0	-1.9	-2.0	1.8	-0.5
Std. dev. reaction times	1.3	2.4	4.8	1.1	0.7	-1.7	2.2
Reaction time trials completed	1.7	3.2	4.9	-2.2	-2.1	1.5	-1.0
Reaction time trials AUC	1.7	3.2	5.0	-2.2	-2.2	1.4	-1.0
Run reversals in cocaine runway, females	0.6	0.6	1.6	-0.6	-0.1	0.5	-1.3
Run reversals in cocaine runway, males	0.6	0.6	1.7	0.2	-0.7	-1.3	-0.3
Latency to leave start box in cocaine runway	0.8	0.9	2.1	-0.8	-1.4	-0.5	0.7
Latency to leave start box in cocaine runway, F	0.7	0.8	1.5	-0.6	-1.2	-0.6	0.9
Latency to leave start box in cocaine runway, M	0.5	0.4	1.1	-0.7	-1.0	-0.3	0.2
Std. dev. time between licks in bursts	2.5	3.4	4.9	2.2	2.1	-1.5	1.4
Total sessions with >9 infusions	0.1	0.1	0.2	0.5	0.4	-0.3	-0.3
Short access day 1 total inactive lever presses	1.4	1.9	3.1	1.8	1.6	-1.4	0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.3	0.4	0.4	-0.3
Short access day 1 total infusions	0.1	0.1	0.4	0.3	0.2	-0.1	-0.7
Short access day 10 total infusions	0.6	0.8	1.9	0.7	0.2	-1.4	0.7
Short access total infusions	0.1	0.2	0.3	0.5	0.3	-0.4	-0.3
Short access day 1 locomotion	1.1	1.3	3.4	0.8	0.3	-1.8	1.1
Short access day 10 total locomotion	0.3	0.5	0.8	0.7	0.8	-0.9	0.4
Short access total locomotion	1.0	1.2	2.2	1.2	0.8	-1.5	0.8
One hour access (0.3 mA shock)	0.2	0.3	0.5	0.7	0.4	-0.4	-0.5
Compulsive drug intake	1.6	1.9	3.5	1.8	1.9	-0.7	0.3
One hour access (shock baseline)	0.2	0.3	0.8	-0.5	-0.9	0.0	-0.3
Social response proportion	3.0	3.5	4.2	-2.0	-1.9	2.1	-1.3
Social responses	0.7	0.9	1.9	-0.7	-0.4	1.4	-1.0
Social time	0.9	1.3	1.9	1.1	1.4	-1.1	0.9
Soleus weight	2.5	7.3	16.0	-3.4	-4.0	-0.3	1.2
Bone: stiffness	0.5	0.9	1.7	1.3	1.2	-0.5	-0.2
Tibialis anterior weight	1.7	5.7	9.1	-2.2	-3.0	-1.9	2.3
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.6	1.0	1.3	0.8	-0.6
Time to tail flick, vehicle, after self-admin	2.3	3.1	4.5	-1.9	-2.0	2.1	-0.6
Time to tail flick, test, before self-admin	1.0	1.1	2.1	1.3	1.5	-0.3	-0.7
Time to tail flick, test, after self-admin	1.0	1.1	2.6	0.2	1.0	1.6	-0.8
Delta time to tail flick, vehicle, before/after SA	2.1	2.0	3.3	-1.6	-1.8	1.3	-0.7
Delta time to tail flick, test, before/after SA	1.6	1.7	4.4	-1.2	-0.4	2.1	-0.9
Tibia length	6.5	17.9	31.8	5.6	5.6	-2.5	1.6
Ambulatory time before self-admin	0.4	0.6	1.2	-0.2	-0.8	-1.1	0.8
Ambulatory time after self-admin	1.8	2.1	5.6	-1.5	-2.4	-0.7	0.5
Bone: tissue strength	0.4	0.4	0.7	0.8	0.7	-0.7	0.3
Total heroin consumption	0.5	0.6	0.9	-0.7	-1.0	-0.6	0.9
Bone: trabecular number	0.3	0.4	1.1	0.5	1.1	-0.1	-0.5
Bone: trabecular spacing	0.4	0.5	0.9	-0.7	-1.0	-0.2	0.7
Bone: trabecular thickness	0.4	0.5	1.0	0.8	1.0	-0.4	-0.6
Bone: trabecular tissue density	0.3	0.4	1.0	-0.6	-1.0	-0.4	0.6
Water consumed over 24 hours	0.1	0.2	0.3	-0.1	-0.5	-0.4	-0.6
Number of responses in last shaping day	0.4	0.4	0.9	-0.9	-0.9	0.1	-0.2