Hub : Genes

Lmf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Lmf2 0.35 0.09 0.0e+00 0.42 0.51 0.51 0.51 7.0e-36 1.1e-46 1.2e-46 4.1e-47
2 IC gene expression Lmf2 0.33 0.12 1.1e-14 0.25 0.31 0.27 0.29 6.7e-11 1.0e-13 8.0e-12 1.5e-12
3 IL gene expression Lmf2 0.32 0.13 3.7e-05 0.14 0.21 0.17 0.2 3.7e-04 8.5e-06 7.5e-05 1.8e-05
4 BLA gene expression Lmf2 0.3 0.11 1.9e-12 0.17 0.21 0.23 0.22 2.2e-09 1.7e-11 2.8e-12 8.3e-12
5 OFC gene expression Lmf2 0.49 0.13 7.1e-08 0.25 0.31 0.3 0.29 1.1e-06 3.6e-08 6.3e-08 1.0e-07
6 PL gene expression Lmf2 0.36 0.11 0.0e+00 0.22 0.3 0.27 0.3 2.0e-23 1.5e-32 1.1e-29 1.5e-32
7 NAcc gene expression Lmf2 0.31 0.12 0.0e+00 0.29 0.3 0.31 0.31 5.0e-44 2.0e-46 1.0e-47 4.5e-48
8 Adipose mRNA stability Lmf2 0.13 0.09 8.4e-07 0.04 0.05 0.05 0.05 1.0e-05 2.1e-06 2.8e-06 3.8e-06
9 Eye gene expression Lmf2 0.46 0.19 4.5e-04 0.1 0.1 0.04 0.13 1.4e-02 1.2e-02 9.3e-02 5.4e-03
10 Liver mRNA stability Lmf2 0.03 0.02 3.1e-03 0.01 0.01 -0 0.01 8.5e-03 3.9e-02 3.8e-01 5.9e-02
11 LHb gene expression Lmf2 0.46 0.16 1.4e-08 0.28 0.27 0.2 0.27 1.9e-07 4.5e-07 1.3e-05 4.5e-07
12 Adipose gene expression Lmf2 0.69 0.06 0.0e+00 0.61 0.63 0.63 0.63 2.7e-86 9.6e-91 2.3e-90 1.8e-89
13 Brain gene expression Lmf2 0.45 0.1 0.0e+00 0.45 0.53 0.53 0.54 8.0e-46 4.2e-58 2.5e-58 5.1e-59
14 Liver gene expression Lmf2 0.27 0.1 0.0e+00 0.18 0.19 0.19 0.2 1.5e-19 1.1e-20 7.8e-21 2.8e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.71.23.41.21.41.01.20.30.70.90.41.81.61.00.71.00.7
Area under the delay curve0.50.52.60.00.0-0.30.1-0.10.30.80.5-0.41.10.70.91.11.6
BMI with tail4.013.919.0-4.4-4.3-4.0-3.7-3.5-3.9-4.1-3.8-2.8-3.9-3.8-3.9-3.9-0.2
BMI without tail1.64.97.3-2.2-2.4-1.9-2.0-1.6-2.2-2.7-2.1-1.5-2.7-2.4-2.6-2.7-1.3
Body weight1.77.611.0-3.3-3.3-3.0-2.9-2.4-2.7-3.0-2.6-2.4-2.8-3.0-2.8-2.9-0.4
Weight adjusted by age2.94.47.1-2.5-2.7-2.6-2.2-2.1-2.2-2.0-2.0-2.4-1.7-1.9-1.9-1.70.6
Bone surface0.50.93.10.50.70.10.6-0.40.20.80.11.11.71.10.71.01.8
Bone volume0.71.33.50.91.20.61.1-0.00.61.10.51.51.91.41.01.31.4
Breakpoint value in progressive ratio session0.30.40.9-0.9-0.8-0.9-0.6-0.8-0.7-0.5-0.6-0.7-0.3-0.3-0.4-0.30.5
Number of licking bursts0.00.10.40.20.40.40.30.30.10.00.10.60.1-0.0-0.00.0-0.4
Context. condit. distance diff. score1.21.53.0-1.1-1.2-0.8-1.0-0.5-0.9-1.5-0.9-1.1-1.7-1.6-1.5-1.5-1.1
Locomotion velocity, session 10.20.20.5-0.7-0.4-0.40.0-0.4-0.4-0.6-0.40.6-0.5-0.7-0.6-0.4-0.1
Locomotion distance, session 11.72.23.51.41.41.11.51.31.51.61.60.91.91.81.71.80.8
Locomotion velocity, session 20.91.01.7-1.1-0.8-0.9-0.7-1.1-1.3-1.2-1.3-0.1-1.0-1.1-1.3-1.10.1
Locomotion distance, session 20.71.01.71.10.90.70.80.81.11.11.10.21.31.31.11.30.5
Locomotion velocity, session 30.50.53.40.80.40.90.10.80.4-0.40.1-0.2-0.5-0.6-0.5-0.7-1.8
Locomotion distance, session 30.30.30.70.60.80.80.80.40.50.30.40.80.40.20.20.2-0.5
Stereotopy head waving bouts, day 31.31.52.31.11.40.91.30.21.01.40.91.41.51.51.21.51.2
Stereotopy head waving duration, day 30.60.71.21.01.10.91.10.50.91.00.70.80.80.90.70.80.2
Locomotion velocity, session 70.40.42.1-0.10.10.40.1-0.1-0.3-0.5-0.30.8-0.8-0.8-0.7-0.8-1.5
Locomotion distance, session 70.10.10.7-0.1-0.30.0-0.10.20.0-0.30.10.0-0.4-0.5-0.2-0.3-0.9
Stereotopy head waving bouts, day 70.50.51.41.20.90.70.80.40.60.70.40.40.90.90.60.80.4
Stereotopy head waving duration, day 70.91.12.41.61.51.41.30.80.90.90.61.20.90.90.60.7-0.3
Locomotion velocity, session 81.11.32.9-0.7-0.5-0.4-0.6-1.1-1.2-1.4-1.4-0.1-1.4-1.5-1.7-1.5-0.8
Locomotion distance, session 80.71.02.0-0.9-1.2-1.1-1.2-0.8-0.8-1.2-0.9-1.4-0.9-0.9-1.1-1.00.1
Degree of sensitization distance1.92.03.1-1.7-1.8-1.7-1.8-1.4-1.4-1.3-1.3-1.3-1.3-1.3-1.2-1.10.3
Degree of sensitization stereotypy0.10.10.60.80.50.60.30.50.30.10.10.00.20.1-0.00.0-0.6
Conditioned locomotion0.30.41.2-0.4-0.4-0.3-0.3-0.3-0.6-0.8-0.60.3-1.1-0.7-0.9-0.9-0.4
Cocaine response after cond. corrected1.11.42.0-1.1-1.1-1.0-1.3-1.0-1.3-1.4-1.3-1.0-1.0-1.4-1.4-1.3-0.5
Cocaine response after cond. not corrected2.63.04.4-1.6-1.7-1.4-1.8-1.3-1.8-2.1-1.9-1.5-1.8-2.1-2.0-2.1-0.9
Cocaine response before conditioning0.91.11.9-1.0-1.0-0.8-0.8-0.7-1.1-1.2-1.1-0.7-1.4-1.2-1.2-1.3-0.4
Saline control response1.52.03.3-1.7-1.5-1.8-1.7-1.7-1.7-1.3-1.6-1.1-0.8-1.1-1.1-0.91.2
Bone: connectivity density0.61.04.21.11.41.01.20.20.50.70.22.01.30.80.40.60.4
Bone: cortical apparent density2.53.54.42.02.01.92.11.82.02.02.01.91.81.81.91.9-0.1
Bone: cortical area0.81.22.7-1.7-1.2-1.6-1.0-1.6-1.3-0.8-1.0-0.5-0.3-0.4-0.6-0.51.2
Bone: cortical porosity1.01.12.2-1.3-1.1-1.5-1.1-1.5-1.2-0.9-1.2-0.2-0.3-0.6-0.8-0.61.3
Bone: cortical porosity2.22.44.6-1.9-1.8-2.2-1.8-1.8-1.7-1.4-1.6-1.1-0.7-1.1-1.2-1.01.4
Bone: cortical thickness0.00.10.2-0.4-0.2-0.30.2-0.2-0.00.20.20.20.40.30.20.30.3
Bone: cortical thickness0.10.20.9-0.3-0.00.20.60.40.10.10.40.4-0.4-0.10.1-0.2-1.0
Bone: cortical tissue density2.23.03.91.91.91.82.01.71.91.91.91.71.61.71.71.8-0.2
Condit. Reinf. active minus inactive responses1.82.04.0-1.7-1.0-1.4-1.0-2.0-1.9-1.4-1.9-0.0-1.3-1.3-1.6-1.20.6
Condit. Reinf. active-inactive response ratio0.30.30.8-0.50.1-0.10.1-0.7-0.7-0.5-0.70.9-0.4-0.5-0.7-0.40.1
Condit. Reinf. active responses2.63.25.6-2.1-1.5-1.7-1.5-2.2-2.4-1.9-2.3-0.5-1.9-1.7-2.1-1.70.4
Condit. Reinf. inactive responses1.72.13.1-1.7-1.5-1.6-1.4-1.5-1.8-1.5-1.6-1.1-1.5-1.4-1.5-1.40.3
Incentive salience index mean2.93.56.6-2.3-1.6-2.0-1.6-2.6-2.5-1.9-2.4-0.4-1.7-1.6-2.0-1.50.9
Condit. Reinf. lever presses2.23.15.0-2.1-1.7-2.0-1.7-2.2-2.2-1.8-2.1-0.8-1.7-1.6-1.8-1.40.9
Condit. Reinf. active minus inactive responses0.40.63.2-0.6-0.3-0.8-0.1-1.0-0.20.6-0.0-0.10.70.80.70.71.8
Condit. Reinf. active-inactive response ratio0.20.20.5-0.20.2-0.10.2-0.40.10.50.20.70.70.50.50.50.7
Condit. Reinf. active responses0.81.03.5-1.4-1.0-1.5-0.8-1.6-1.0-0.1-0.7-0.9-0.20.1-0.0-0.01.9
Condit. Reinf. inactive responses0.81.02.2-1.3-1.3-1.3-1.0-1.1-1.0-0.7-0.8-1.5-1.0-0.5-0.6-0.60.9
Condit. Reinf. lever presses1.52.14.0-2.0-1.6-1.9-1.5-2.0-1.7-1.1-1.5-1.5-1.1-0.8-1.0-1.01.1
Condit. Reinf. lever reinforcers received0.71.04.0-1.3-0.9-1.4-0.7-1.6-0.9-0.0-0.7-0.7-0.00.30.10.12.0
Conditioned reinforcement - actives0.71.22.2-1.2-1.3-1.5-1.2-1.5-1.2-1.0-1.2-0.9-0.7-0.7-0.9-0.80.9
Conditioned reinforcement - inactives0.10.20.5-0.5-0.5-0.4-0.3-0.3-0.4-0.5-0.4-0.4-0.5-0.7-0.6-0.5-0.2
Conditioned locomotion2.32.94.2-1.8-2.0-1.9-1.7-1.5-1.8-1.9-1.7-1.7-1.8-1.7-1.8-1.8-0.2
Patch foraging indifference point 0 sec0.40.71.1-1.0-0.9-0.9-0.9-0.8-1.0-0.8-0.9-1.0-0.7-0.8-0.7-0.70.3
Patch foraging indifference point AUC0.60.96.9-0.6-0.4-1.1-0.2-1.2-0.20.3-0.20.50.90.70.40.82.6
Delay disc. indifference point, 0s delay2.02.25.1-1.7-1.6-2.1-1.7-2.3-1.7-1.1-1.6-1.1-0.6-0.5-0.9-0.61.8
Delay disc. indifference point, 16s delay0.20.21.5-0.4-0.1-0.4-0.2-0.5-0.20.2-0.1-0.30.40.00.10.41.2
Delay disc. indifference point, 2s delay1.71.810.40.10.2-0.60.2-0.80.21.30.40.21.91.71.51.93.2
Delay disc. indifference point, 24s delay0.30.31.1-0.9-0.5-0.4-0.4-0.3-0.6-0.6-0.4-0.2-0.6-1.0-0.6-0.6-0.0
Delay disc. indifference point, 4s delay0.50.62.20.2-0.1-0.3-0.10.10.50.90.6-0.71.10.61.01.11.5
Delay disc. indifference point, 8s delay0.81.01.80.70.70.60.70.91.11.21.3-0.01.30.91.31.30.6
Indifference point function ln k1.22.24.9-1.2-1.6-1.1-1.5-0.6-1.3-1.6-1.2-2.2-1.8-1.4-1.4-1.7-1.5
Indifference point function log k1.22.24.9-1.2-1.6-1.1-1.5-0.6-1.3-1.6-1.2-2.2-1.8-1.4-1.4-1.7-1.5
Patch foraging total patch changes 0 sec0.20.30.5-0.6-0.6-0.6-0.6-0.5-0.7-0.5-0.6-0.7-0.5-0.7-0.4-0.50.2
Patch foraging total patch changes 12 sec0.60.84.0-0.9-0.7-1.2-0.7-1.5-0.8-0.3-0.9-0.2-0.0-0.1-0.3-0.02.0
Patch foraging total patch changes 18 sec0.81.24.40.30.80.21.0-0.20.51.20.61.31.41.11.21.42.1
Patch foraging total patch changes 24 sec0.30.41.9-0.00.50.00.7-0.7-0.10.5-0.11.20.40.80.40.61.4
Patch foraging total patch changes 6 sec0.40.63.1-0.7-0.8-1.1-0.8-0.9-0.6-0.3-0.6-0.60.2-0.4-0.10.01.7
Patch foraging time to switch 0 sec0.20.51.10.91.00.90.80.60.60.70.50.90.60.60.50.6-0.2
Patch foraging water rate 0 sec0.40.92.1-0.9-1.3-0.9-1.0-0.3-0.6-1.0-0.5-1.4-1.1-1.0-0.7-1.0-0.7
Patch foraging water rate 12 sec1.22.54.4-1.7-2.0-1.7-1.8-1.0-1.5-1.7-1.3-2.1-1.6-1.4-1.4-1.6-0.7
Patch foraging water rate 18 sec2.33.68.2-1.6-2.0-1.4-1.9-0.7-1.6-2.1-1.4-2.9-2.0-2.2-1.8-2.1-1.9
Patch foraging water rate 24 sec0.91.24.1-0.7-1.2-0.6-1.00.1-0.7-1.2-0.6-2.0-1.2-1.2-1.0-1.3-1.4
Patch foraging water rate 6 sec0.50.72.3-0.6-1.1-0.7-1.0-0.1-0.6-0.9-0.5-1.5-0.9-0.7-0.7-0.9-0.9
Seeking ratio, delayed vs. immediate footshock0.50.61.51.21.00.90.70.60.70.80.61.00.70.80.70.8-0.0
Distance traveled before self-admin1.21.52.21.41.31.11.31.11.31.31.31.41.31.51.31.30.2
Distance traveled after self-admin0.20.20.50.70.60.70.40.50.30.20.30.70.00.10.10.1-0.6
Extensor digitorum longus weight0.21.01.8-1.0-1.0-0.8-0.7-0.5-1.0-1.3-0.9-0.5-1.1-1.3-1.2-1.3-0.7
Bone: elastic displacement0.20.21.10.60.30.2-0.10.40.20.20.2-0.41.00.30.40.40.3
Bone: elastic work0.30.40.8-0.7-0.9-0.9-0.7-0.5-0.7-0.6-0.6-0.90.1-0.6-0.6-0.60.3
Bone: endosteal estimation0.51.02.0-1.3-1.2-1.4-1.1-1.3-1.3-0.9-1.1-0.8-0.4-0.6-0.7-0.71.0
Bone: endosteal perimeter2.04.310.7-2.6-2.0-2.9-2.1-3.3-2.5-1.4-2.3-0.9-0.6-0.6-1.2-0.72.9
Epididymis fat weight2.37.814.4-3.5-2.7-3.1-2.8-3.8-3.3-2.7-3.3-1.5-2.6-2.3-2.8-2.41.1
Delta time in closed arm before/after self-admin0.10.10.3-0.2-0.3-0.3-0.20.00.00.10.1-0.10.2-0.10.30.30.5
Delta time in open arm before/after self-admin0.00.00.10.10.00.0-0.1-0.1-0.0-0.0-0.1-0.3-0.10.4-0.1-0.1-0.2
Diff in mean of infusions in LGA sessions2.12.54.9-1.9-1.7-2.1-1.6-2.2-1.8-1.4-1.9-1.0-1.1-1.0-1.4-1.11.2
Delay discount exponential model param0.40.51.7-0.2-0.10.1-0.2-0.2-0.5-0.8-0.70.4-1.0-0.6-0.9-1.0-1.3
Extinction: sum of active levers before priming0.20.21.2-0.2-0.3-0.5-0.4-0.5-0.20.3-0.1-0.40.50.20.40.51.1
Active lever presses in extinction session 62.32.33.0-1.4-1.7-1.5-1.5-1.3-1.6-1.7-1.5-1.6-1.6-1.7-1.6-1.6-0.4
Bone: final force0.10.20.8-0.10.1-0.10.6-0.00.10.40.30.90.60.50.40.40.5
Bone: final moment0.20.31.00.10.30.10.70.20.30.50.51.00.70.60.50.50.5
Food consumed during 24 hour testing period1.72.33.3-1.6-1.7-1.4-1.6-1.2-1.6-1.8-1.5-1.1-1.5-1.8-1.7-1.8-0.6
Glucose0.10.10.8-0.1-0.2-0.5-0.1-0.3-0.00.20.00.20.60.30.30.40.9
Heart weight0.20.31.5-0.2-0.20.1-0.00.0-0.2-0.5-0.30.1-0.9-0.4-0.6-0.8-1.2
Delay discount hyperbolic model param0.60.72.3-0.3-0.3-0.0-0.4-0.2-0.6-1.0-0.80.2-1.2-0.9-1.1-1.2-1.5
Intermittent access intake day 1-15 change0.71.52.5-1.2-1.5-1.4-1.6-1.3-1.2-1.1-1.2-1.6-1.0-1.0-1.0-1.00.4
Intermittent access intake escalation0.81.72.9-1.3-1.6-1.5-1.7-1.4-1.3-1.2-1.3-1.6-1.0-1.1-1.0-1.10.4
Intermittent access intake escalation 23.43.96.7-2.0-2.3-2.5-2.4-2.6-2.1-1.7-2.2-2.2-1.3-1.5-1.6-1.41.3
Intermitt. access day 1 inactive lever presses0.31.32.3-1.3-1.4-1.5-1.2-1.2-1.2-1.0-1.1-1.5-0.8-0.9-0.9-0.80.6
Intermitt. access day 15 inactive lever presses1.22.54.3-1.2-1.6-1.1-1.5-0.7-1.3-1.9-1.4-1.7-2.1-1.9-1.8-2.1-1.5
Intermitt. access escalation Index0.40.61.10.91.01.00.50.80.70.70.71.00.50.70.70.5-0.6
Intermittent access day 1 total infusions0.00.10.30.20.20.30.10.30.1-0.10.20.3-0.1-0.1-0.0-0.2-0.5
Intermittent access day 15 total infusions0.20.30.6-0.4-0.7-0.5-0.8-0.4-0.4-0.5-0.4-0.6-0.5-0.5-0.4-0.5-0.1
Intermittent access terminal intake (last 3 days)1.62.13.4-1.5-1.8-1.7-1.9-1.6-1.4-1.4-1.5-1.5-1.2-1.3-1.2-1.20.4
Intermittent access total infusions0.20.20.5-0.5-0.6-0.6-0.7-0.5-0.5-0.5-0.5-0.3-0.4-0.4-0.4-0.50.0
Intermittent access day 1 locomotion0.00.00.1-0.0-0.1-0.2-0.2-0.2-0.1-0.0-0.1-0.10.10.20.10.00.2
Intermittent access day 15 total locomotion0.81.42.3-1.4-1.5-1.5-1.3-1.2-1.2-1.2-1.1-1.3-1.0-0.9-1.0-1.00.4
Intermittent access total locomotion0.70.81.5-0.8-1.1-0.9-1.0-0.7-0.9-1.0-0.8-1.2-0.9-0.7-0.8-1.0-0.2
Intermittent access standard deviation0.20.40.8-0.2-0.6-0.2-0.6-0.1-0.3-0.6-0.4-0.9-0.7-0.8-0.6-0.8-0.9
Left kidney weight5.324.631.1-5.3-5.5-5.1-5.6-4.6-5.2-5.4-5.2-4.6-4.8-5.3-5.1-5.0-0.2
Right kidney weight7.734.945.0-6.3-6.6-5.9-6.5-5.1-6.0-6.4-5.9-5.6-6.0-6.7-6.2-6.2-0.9
Cocaine induced anxiety0.81.12.4-0.7-1.1-0.8-1.6-0.6-0.8-1.1-0.9-1.4-1.2-1.2-0.9-1.2-0.7
Post-drug Anxiety1.11.12.0-0.7-1.0-0.6-1.4-0.4-0.7-1.2-0.9-1.2-1.3-1.4-1.1-1.3-1.1
Baseline Anxiety0.50.61.00.70.90.91.00.80.80.70.80.80.60.60.60.7-0.1
Tail length0.31.21.71.31.31.21.00.81.11.10.91.21.31.20.91.10.1
Length with tail0.00.10.4-0.4-0.4-0.5-0.7-0.4-0.00.0-0.1-0.60.3-0.20.10.10.5
Length without tail0.72.24.3-1.9-1.9-2.1-2.0-1.8-1.3-1.0-1.3-1.8-0.5-1.3-0.8-0.81.2
Times rat made contact with spout0.91.05.90.2-0.50.4-0.41.10.3-0.60.3-1.6-0.9-1.0-0.5-1.0-2.4
Lifetime Intake0.20.20.4-0.5-0.6-0.5-0.6-0.4-0.4-0.6-0.4-0.4-0.5-0.5-0.4-0.5-0.2
Liver weight, left0.40.72.1-1.2-1.3-1.4-1.0-1.0-0.7-0.6-0.6-0.7-0.3-0.5-0.4-0.31.0
Liver weight, right0.10.10.6-0.0-0.3-0.4-0.1-0.00.30.30.3-0.40.30.20.50.50.8
Locomotor activity0.91.42.7-1.2-1.2-1.6-1.3-1.6-1.4-0.9-1.4-1.4-0.5-0.2-0.8-0.61.5
Locomotor testing distance0.40.81.81.10.90.70.90.80.70.90.70.20.91.41.01.00.4
Locomotor testing rearing0.51.17.1-0.7-0.7-1.4-0.4-1.2-0.60.2-0.5-0.70.80.70.50.82.7
Locomotion in novel chamber0.81.14.30.0-0.40.2-0.10.5-0.4-1.2-0.4-0.7-1.5-1.4-1.2-1.5-2.1
Locomotion in novel chamber post-restriction0.20.31.20.30.2-0.30.2-0.6-0.50.1-0.40.90.30.70.10.31.1
Fecal boli incidents, locomotor time 10.40.60.90.90.80.90.90.90.80.90.90.30.80.50.90.8-0.1
Change in fecal boli incidents, locomotor task0.60.61.6-0.8-0.9-0.9-1.2-0.6-0.7-0.6-0.7-1.3-0.5-0.7-0.5-0.50.1
Time >=10cm from walls, locomotor time 10.91.01.8-1.0-1.1-1.2-1.3-1.3-1.0-0.8-1.1-1.1-0.6-0.9-0.8-0.60.7
Bouts of movement, locomotor time 10.30.30.9-0.10.10.10.1-0.2-0.5-0.6-0.50.7-0.7-0.9-0.8-0.6-0.7
Total resting periods, locomotor time 10.20.20.90.20.40.50.50.2-0.1-0.2-0.00.9-0.3-0.6-0.3-0.2-0.6
Rest time, locomotor task time 10.50.61.71.00.91.30.81.30.70.30.80.60.0-0.10.30.1-1.2
Distance moved, locomotor task time 10.50.71.9-1.0-0.9-1.2-1.0-1.4-1.0-0.6-1.1-0.2-0.4-0.1-0.6-0.40.7
Vertical activity count, locomotor time 10.92.14.4-1.7-1.7-1.9-1.6-2.1-1.6-1.3-1.6-1.2-0.9-0.6-1.2-1.01.0
Time >=10cm from walls, locomotor time 22.03.04.3-2.1-2.0-2.1-2.0-1.9-2.0-1.8-1.9-1.7-1.4-1.3-1.6-1.40.4
Bouts of movement, locomotor time 20.20.40.70.70.60.60.50.60.80.50.80.50.60.40.70.60.0
Total resting periods, locomotor time 20.20.40.60.80.60.60.50.50.80.50.80.70.60.50.70.60.2
Rest time, locomotor task time 21.21.53.11.51.51.81.11.61.41.01.41.00.80.61.10.9-1.0
Distance moved, locomotor task time 22.22.64.5-1.9-1.9-2.1-1.5-2.0-2.0-1.6-1.9-0.9-1.3-0.8-1.5-1.40.8
Vertical activity count, locomotor time 22.13.05.1-1.9-2.1-2.3-1.5-2.2-2.0-1.7-1.9-1.6-1.4-0.8-1.6-1.41.0
Light reinforcement 10.71.83.2-1.6-1.4-1.6-1.4-1.8-1.5-1.2-1.6-1.3-0.9-0.7-1.2-1.01.0
Light reinforcement 23.96.09.8-2.9-2.9-3.1-3.0-2.9-2.6-2.2-2.5-2.7-1.5-1.9-1.9-1.81.4
Bone: marrow area0.40.81.6-1.1-1.0-1.3-0.9-1.2-1.1-0.7-1.0-0.7-0.3-0.5-0.6-0.51.0
Bone: maximum diameter1.62.95.1-2.3-1.7-2.0-1.8-2.2-2.2-1.6-1.9-0.8-1.5-1.3-1.5-1.41.0
Bone: maximum force0.00.10.3-0.4-0.2-0.30.3-0.0-0.10.00.10.40.50.10.10.10.3
Bone: maximum moment0.10.10.5-0.10.0-0.10.40.20.10.20.30.50.70.20.20.20.2
Mean time between licks in bursts1.94.77.22.42.62.62.72.42.22.02.22.41.71.71.91.8-0.8
Mean num. licks in bursts0.20.32.40.1-0.5-0.1-0.40.50.3-0.10.3-1.5-0.3-0.20.1-0.3-0.9
Cd content in liver0.30.40.90.20.50.30.80.30.50.70.60.40.80.60.80.90.8
Co content in liver0.81.01.6-1.2-0.9-1.2-1.2-1.2-1.2-1.0-1.3-0.6-0.2-0.8-0.9-0.60.8
Cu content in liver2.22.65.31.81.82.31.92.31.81.21.81.40.40.71.10.7-2.1
Fe content in liver0.10.20.9-0.1-0.1-0.3-0.1-0.30.10.30.1-0.30.70.50.40.51.0
K content in liver0.10.10.90.30.60.40.4-0.30.00.1-0.20.9-0.00.1-0.1-0.10.1
Mg content in liver0.30.31.00.60.70.30.4-0.10.20.50.00.80.70.70.40.51.0
Mn content in liver0.20.20.8-0.30.0-0.2-0.1-0.9-0.6-0.4-0.80.3-0.1-0.2-0.5-0.40.5
Na content in liver3.23.56.81.51.91.22.00.51.52.21.51.82.22.62.12.21.8
Rb content in liver0.20.21.1-0.4-0.4-0.7-0.3-0.7-0.5-0.2-0.5-0.30.10.1-0.1-0.11.0
Se content in liver0.30.40.9-0.3-0.3-0.2-0.3-0.3-0.6-0.8-0.7-0.4-0.9-0.9-0.8-0.8-0.6
Sr content in liver2.32.03.01.61.61.71.71.61.61.31.51.31.11.21.31.1-0.7
Zn content in liver1.11.22.91.31.21.51.21.71.30.81.20.70.40.50.80.5-1.1
Bone: minimum diameter0.50.92.2-1.5-0.9-1.3-0.7-1.5-1.2-0.7-1.00.0-0.3-0.5-0.7-0.51.0
Time in familiar zone, hab. session 10.30.31.70.2-0.20.3-0.40.6-0.0-0.5-0.1-0.4-0.6-0.6-0.5-0.7-1.3
Time in novel zone, hab. session 10.50.51.60.20.60.10.8-0.30.20.70.21.01.10.80.60.91.3
Total zone transitions, hab. session 12.12.94.51.71.31.11.51.51.92.02.00.32.02.12.12.10.9
Total locomotion distance, hab. session 10.30.42.1-0.1-0.5-0.6-0.50.10.10.30.2-1.40.60.50.50.41.1
Locomotion velocity, hab. session 10.30.52.2-0.1-0.5-0.6-0.40.10.20.40.3-1.50.70.60.60.61.3
Time in familiar zone, hab. session 21.01.12.1-0.6-0.6-0.2-1.0-0.4-0.9-1.3-0.9-0.3-1.4-1.4-1.2-1.5-1.4
Time in novel zone, hab. session 21.41.42.31.11.20.91.50.71.11.31.01.21.51.21.11.40.9
Total zone transitions, hab. session 20.10.21.50.0-0.4-0.1-0.30.50.1-0.20.2-1.2-0.2-0.1-0.0-0.2-0.4
Total locomotion distance, hab. session 21.21.55.8-1.2-1.5-1.3-1.4-0.6-1.0-1.2-0.9-2.4-0.9-1.0-1.0-1.1-0.0
Locomotion velocity, hab. session 21.21.66.6-1.2-1.6-1.4-1.5-0.6-1.0-1.2-0.8-2.6-0.9-0.9-0.9-1.00.1
Novel to familiar place preference ratio0.60.72.01.01.21.31.10.80.60.40.41.40.20.10.10.1-1.0
Novelty place preference0.50.61.80.91.01.20.90.70.40.10.21.30.0-0.1-0.1-0.1-1.1
Time in novel zone, NPP test0.70.82.01.11.21.41.10.90.60.20.41.40.1-0.1-0.1-0.1-1.3
Total zone transitions, NPP test0.71.01.61.20.70.70.81.21.31.11.3-0.11.01.11.21.20.1
Total locomotion distance, NPP test0.20.21.4-0.3-0.6-0.7-0.6-0.2-0.2-0.2-0.2-1.20.00.0-0.00.10.8
Locomotion velocity, NPP test0.20.31.7-0.4-0.7-0.8-0.7-0.3-0.3-0.3-0.2-1.3-0.1-0.1-0.1-0.00.7
Intraocular pressure0.30.41.7-0.6-0.2-0.70.1-0.9-0.7-0.1-0.40.40.00.90.00.31.3
Delta distance traveled before/after self-admin2.32.54.6-1.2-1.2-0.8-1.4-0.9-1.5-1.9-1.5-1.1-2.1-2.1-1.9-2.1-1.4
Delta ambulatory time before/after self-admin1.11.42.8-0.8-0.8-0.5-0.8-0.5-1.1-1.4-1.1-0.8-1.7-1.6-1.5-1.7-1.2
Parametrial fat weight0.20.51.3-1.1-1.1-1.1-0.7-0.7-0.6-0.6-0.4-0.6-0.6-0.4-0.4-0.50.2
Pavlov. Cond. lever latency1.82.23.31.81.51.71.41.81.81.51.71.11.61.21.51.3-0.7
Pavlov. Cond. magazine entry latency0.20.21.40.20.70.40.5-0.20.10.40.11.20.00.40.30.40.5
Pavlov. Cond. change in total contacts0.30.31.2-0.70.2-0.30.3-1.0-0.6-0.0-0.51.1-0.30.1-0.20.21.0
Pavlov. Cond. index score0.10.10.5-0.40.0-0.2-0.0-0.7-0.5-0.1-0.40.4-0.5-0.1-0.3-0.00.6
Pavlov. Cond. latency score0.30.30.9-0.7-0.2-0.5-0.3-1.0-0.8-0.4-0.70.1-0.8-0.3-0.5-0.30.6
Pavlov. Cond. lever contacts1.51.83.0-1.6-1.1-1.4-1.1-1.7-1.7-1.3-1.6-0.5-1.6-1.2-1.5-1.20.7
Pavlov. Cond. magazine entry number0.30.31.4-0.3-0.7-0.4-0.50.2-0.2-0.6-0.2-1.2-0.3-0.5-0.5-0.7-0.7
Pavlov. Cond. intertrial magazine entries1.61.92.9-1.7-1.6-1.7-1.3-1.6-1.6-1.4-1.5-1.3-1.2-1.2-1.4-1.10.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.5-0.30.2-0.10.1-0.5-0.30.1-0.20.6-0.30.1-0.00.20.7
Pavlov. Cond. response bias0.30.40.9-0.7-0.3-0.5-0.5-1.0-0.8-0.5-0.80.3-0.7-0.5-0.6-0.40.6
Pavlov. Cond. lever latency1.41.82.61.61.41.21.51.31.41.31.31.51.41.51.31.40.4
Pavlov. Cond. magazine entry latency0.50.61.1-1.1-0.8-0.8-0.9-0.8-0.8-0.7-0.7-0.5-0.9-0.8-0.7-0.8-0.2
Pavlov. Cond. change in total contacts0.30.41.2-1.0-0.7-1.0-0.6-1.1-0.6-0.0-0.4-0.40.10.00.0-0.01.1
Pavlov. Cond. index score0.91.22.1-1.4-1.3-1.2-1.4-1.2-1.1-0.9-1.0-1.3-1.0-1.1-0.9-1.0-0.1
Pavlov. Cond. latency score1.41.82.9-1.7-1.5-1.4-1.6-1.4-1.4-1.3-1.3-1.4-1.3-1.4-1.2-1.3-0.2
Pavlov. Cond. lever contacts1.52.02.8-1.7-1.5-1.3-1.6-1.4-1.4-1.4-1.4-1.6-1.5-1.5-1.4-1.5-0.3
Pavlov. Cond. magazine entry number0.91.12.11.51.11.11.11.01.10.91.00.91.21.10.91.00.1
Pavlov. Cond. intertrial magazine entries0.10.21.40.4-0.10.2-0.30.60.3-0.20.2-1.20.1-0.2-0.0-0.2-0.6
Pavlov. Cond. lever-magazine prob. diff.1.01.32.2-1.5-1.3-1.3-1.4-1.2-1.1-1.0-1.0-1.3-1.0-1.1-0.9-1.1-0.1
Pavlov. Cond. response bias0.50.71.3-1.1-0.8-0.8-1.0-1.0-0.9-0.7-0.9-0.8-0.8-0.9-0.7-0.8-0.0
Time in closed arm before self-admin0.81.04.20.40.7-0.10.5-1.0-0.30.6-0.21.51.01.80.50.92.0
Time in closed arm after self-admin0.80.85.1-0.7-0.4-1.1-0.5-1.4-0.80.0-0.70.30.50.80.20.52.3
Time in open arm before self-admin0.30.31.00.40.40.70.61.00.70.30.70.30.1-0.50.30.1-0.8
Time in open arm after self-admin0.00.00.20.0-0.10.1-0.10.10.1-0.00.1-0.4-0.1-0.3-0.1-0.1-0.4
Bone: periosteal estimation0.81.63.4-1.8-1.4-1.8-1.3-1.8-1.6-1.0-1.3-0.8-0.4-0.5-0.8-0.71.4
Bone: periosteal perimeter2.13.57.9-2.5-1.9-2.6-2.0-2.8-2.3-1.5-2.1-1.1-0.8-0.8-1.3-1.02.0
Bone: post-yield work1.31.83.01.31.21.41.41.71.71.41.71.11.11.11.41.2-0.7
Progressive ratio test 1 active lever presses0.30.31.60.60.50.80.50.80.50.10.50.2-0.1-0.3-0.0-0.2-1.3
Progressive ratio test 1 breakpoint0.30.31.40.60.60.80.60.80.60.10.50.4-0.1-0.20.0-0.1-1.2
Progressive ratio test 1 inactive lever presses0.10.20.4-0.5-0.5-0.5-0.5-0.5-0.4-0.4-0.4-0.3-0.3-0.6-0.4-0.30.1
Progressive ratio test 2 active lever presses0.81.01.4-1.0-1.1-1.0-0.8-0.8-0.9-1.1-0.9-1.0-1.0-1.2-1.1-1.1-0.2
Progressive ratio test 2 breakpoint0.60.71.1-0.9-1.0-0.9-0.7-0.7-0.8-1.0-0.8-0.9-0.8-1.0-0.9-0.9-0.1
Progressive ratio test 2 inactive lever presses0.81.42.2-1.3-1.5-1.4-1.3-1.2-1.1-1.2-1.1-1.1-1.0-1.2-1.1-1.10.2
Incentive Sensitization - Responses1.52.13.4-1.7-1.7-1.9-1.4-1.8-1.6-1.4-1.6-1.3-1.1-1.1-1.4-1.20.8
Incentive Sensitization - Breakpoint1.51.93.1-1.6-1.7-1.8-1.3-1.7-1.5-1.4-1.5-1.2-1.1-1.0-1.3-1.10.8
Sum of active levers in priming session hrs 5-60.20.20.5-0.4-0.2-0.3-0.3-0.7-0.6-0.3-0.60.1-0.3-0.3-0.5-0.30.4
Progressive ratio0.20.20.6-0.4-0.3-0.2-0.5-0.3-0.6-0.6-0.6-0.1-0.7-0.7-0.7-0.6-0.3
Food seeking constrained by brief footshock2.93.55.6-2.0-2.4-2.1-2.1-1.4-1.8-2.1-1.7-2.2-1.9-2.0-1.8-1.9-0.1
Seeking ratio, punishment vs. effort0.20.30.8-0.6-0.8-0.9-0.5-0.6-0.3-0.2-0.2-0.70.00.10.0-0.10.8
Retroperitoneal fat weight2.410.416.1-4.0-3.7-3.6-3.3-3.5-3.5-3.4-3.4-2.2-3.3-3.0-3.2-3.10.6
Reaction time number correct0.40.81.21.00.90.80.91.10.90.91.00.30.81.10.90.90.3
Reaction time mean minus median0.10.20.5-0.6-0.3-0.5-0.4-0.7-0.5-0.4-0.6-0.1-0.2-0.3-0.5-0.40.3
Reaction time mean minus median AUC0.10.30.5-0.5-0.5-0.4-0.5-0.6-0.5-0.6-0.6-0.5-0.5-0.6-0.7-0.70.0
Reaction time num false alarms0.10.21.30.30.60.30.4-0.1-0.10.2-0.11.10.10.30.00.20.2
Reaction time num false alarms AUC0.10.10.80.30.60.50.50.2-0.00.00.10.9-0.10.0-0.00.0-0.4
Reaction time trials correct on left0.40.81.21.00.90.80.91.10.90.91.00.30.81.10.90.90.3
Reaction time trials on left0.40.81.31.00.90.91.01.10.90.91.00.40.81.11.00.90.2
Reaction time mean0.50.81.81.01.01.31.11.10.90.50.81.10.30.40.40.3-1.3
Reaction time mean AUC0.50.91.61.01.11.31.21.10.90.60.91.20.40.50.50.4-1.2
Median of all reaction times1.01.43.61.41.41.71.41.51.20.71.11.30.30.50.50.4-1.9
Reaction time omissions0.71.03.21.01.31.31.41.00.80.60.81.80.60.30.50.5-0.7
Reaction time false alarm rate0.10.10.7-0.20.20.00.1-0.4-0.4-0.2-0.40.8-0.3-0.3-0.4-0.3-0.2
Reaction time premature initiation rate4.56.211.7-2.9-2.7-3.1-2.7-3.4-3.0-2.3-2.9-1.9-1.8-1.5-2.2-1.71.8
Reaction time premature initiations1.42.64.7-1.8-1.8-2.1-1.7-2.2-2.0-1.4-1.8-1.5-1.0-0.6-1.3-0.91.6
Std. dev. reaction times0.00.10.4-0.1-0.00.10.10.1-0.0-0.3-0.00.3-0.3-0.3-0.3-0.4-0.6
Reaction time trials completed0.40.81.31.00.90.91.01.10.90.91.00.40.81.11.00.90.2
Reaction time trials AUC0.30.51.00.80.70.70.81.00.70.70.90.20.60.90.80.70.2
Run reversals in cocaine runway, females0.10.10.80.10.20.40.20.50.0-0.20.00.4-0.3-0.6-0.2-0.3-0.9
Run reversals in cocaine runway, males0.50.51.10.20.50.20.50.20.40.80.61.01.00.81.01.01.0
Latency to leave start box in cocaine runway1.21.42.6-1.0-1.3-0.8-0.7-0.2-0.8-1.5-0.7-1.3-1.6-1.4-1.4-1.6-1.3
Latency to leave start box in cocaine runway, F2.22.56.0-0.9-1.2-0.4-0.8-0.1-0.9-1.9-1.0-1.5-2.3-2.0-1.9-2.2-2.5
Latency to leave start box in cocaine runway, M0.20.21.3-0.6-0.7-0.8-0.2-0.4-0.2-0.1-0.0-0.30.20.20.20.21.1
Std. dev. time between licks in bursts1.42.03.7-1.8-1.9-1.9-1.7-1.4-1.3-1.3-1.2-1.8-0.9-1.0-1.0-0.90.9
Total sessions with >9 infusions0.20.20.9-0.2-0.30.10.00.40.0-0.50.1-0.3-0.5-0.6-0.4-0.6-1.0
Short access day 1 total inactive lever presses2.93.86.4-1.9-2.0-1.5-1.6-1.1-1.8-2.4-1.8-1.5-2.4-2.5-2.3-2.4-1.3
Short access day 10 total inactive lever presses4.09.713.0-3.4-3.6-3.5-3.4-3.2-3.4-3.2-3.3-3.2-2.9-2.8-3.1-2.90.5
Short access day 1 total infusions0.60.81.6-0.6-0.8-0.4-0.50.1-0.5-1.1-0.4-0.8-1.1-1.3-1.0-1.2-1.2
Short access day 10 total infusions0.60.81.3-0.9-1.0-0.7-0.9-0.5-0.8-1.1-0.8-0.7-1.1-1.1-0.9-1.1-0.7
Short access total infusions0.40.61.0-0.7-0.9-0.6-0.7-0.2-0.6-0.9-0.5-0.6-0.9-1.0-0.8-1.0-0.7
Short access day 1 locomotion0.70.82.0-0.6-0.9-0.5-0.6-0.2-0.6-1.1-0.6-1.4-1.2-1.0-1.0-1.2-1.1
Short access day 10 total locomotion0.50.91.4-0.9-1.1-0.9-0.8-0.5-1.0-1.2-0.8-1.1-1.1-0.9-1.0-1.1-0.6
Short access total locomotion0.40.40.7-0.6-0.7-0.5-0.5-0.3-0.6-0.9-0.5-0.7-0.8-0.7-0.7-0.9-0.6
One hour access (0.3 mA shock)1.82.13.8-1.5-1.8-1.9-2.0-1.8-1.4-1.2-1.5-1.6-0.9-1.0-1.0-1.00.9
Compulsive drug intake0.00.00.2-0.10.10.10.0-0.2-0.00.1-0.10.50.10.20.10.10.1
One hour access (shock baseline)0.81.22.2-1.1-1.4-1.5-1.4-1.3-1.1-0.9-1.0-1.3-0.6-0.8-0.8-0.70.7
Social response proportion0.20.31.10.30.40.10.4-0.20.20.50.30.60.51.00.50.60.8
Social responses0.10.20.80.10.2-0.20.1-0.6-0.20.2-0.1-0.00.10.90.20.30.9
Social time0.20.31.60.2-0.30.2-0.20.50.1-0.5-0.0-0.4-0.8-0.6-0.5-0.8-1.3
Soleus weight0.82.33.5-1.5-1.7-1.3-1.4-0.9-1.4-1.8-1.4-1.2-1.8-1.8-1.7-1.9-1.0
Bone: stiffness0.20.40.90.30.40.41.00.60.60.60.70.90.70.50.60.6-0.2
Tibialis anterior weight0.00.10.3-0.2-0.1-0.00.1-0.1-0.2-0.4-0.20.5-0.2-0.4-0.4-0.5-0.3
Time to tail flick, vehicle, before self-admin2.42.53.6-1.8-1.8-1.9-1.4-1.8-1.6-1.6-1.6-1.8-1.4-1.5-1.6-1.40.5
Time to tail flick, vehicle, after self-admin0.70.91.7-1.0-1.1-1.1-1.0-1.3-1.1-1.0-1.1-0.7-0.9-0.3-1.0-0.90.3
Time to tail flick, test, before self-admin0.50.51.3-0.5-0.5-0.7-0.6-1.2-0.9-0.7-0.9-0.1-0.7-0.0-0.9-0.70.1
Time to tail flick, test, after self-admin2.42.54.2-1.2-1.6-1.2-1.3-1.0-1.4-1.9-1.4-1.7-2.1-1.6-2.0-2.0-1.3
Delta time to tail flick, vehicle, before/after SA1.11.01.81.11.11.11.00.91.00.90.91.20.81.31.00.9-0.2
Delta time to tail flick, test, before/after SA0.30.30.9-0.2-0.4-0.1-0.20.5-0.1-0.50.0-1.0-0.6-0.8-0.4-0.5-0.8
Tibia length1.43.86.71.81.41.41.51.82.32.42.50.42.42.32.62.40.3
Ambulatory time before self-admin0.50.71.21.10.91.00.81.11.00.70.90.90.60.80.70.6-0.6
Ambulatory time after self-admin0.10.20.80.40.30.50.10.3-0.0-0.3-0.00.5-0.5-0.4-0.3-0.5-0.9
Bone: tissue strength1.41.43.71.70.81.11.01.91.50.91.5-0.01.40.91.10.9-0.6
Total heroin consumption0.20.20.5-0.7-0.5-0.7-0.1-0.6-0.7-0.4-0.5-0.4-0.3-0.1-0.4-0.20.4
Bone: trabecular number0.50.93.51.01.30.91.10.20.50.60.21.91.50.70.40.60.4
Bone: trabecular spacing1.72.35.3-1.6-1.9-1.5-1.8-0.7-1.2-1.4-1.0-2.3-1.9-1.5-1.3-1.4-0.5
Bone: trabecular thickness0.20.21.3-0.4-0.0-0.40.1-0.8-0.30.0-0.30.60.50.40.10.21.1
Bone: trabecular tissue density2.02.94.81.31.51.41.91.62.12.02.21.21.71.82.01.90.3
Water consumed over 24 hours0.30.52.8-0.5-0.9-0.7-0.9-0.2-0.3-0.6-0.2-1.7-0.0-0.5-0.3-0.4-0.3
Number of responses in last shaping day0.50.51.40.70.60.81.11.20.90.50.90.20.40.30.40.3-0.7