Hub : Genes

Lima1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Lima1 0.06 0.05 6.7e-06 0.05 0.05 0.05 0.05 8.9e-06 8.8e-06 2.6e-05 2.7e-05
2 pVTA gene expression Lima1 0.04 0.04 2.1e-03 0.02 0.02 0.01 0.01 1.9e-02 1.3e-02 1.0e-01 3.5e-02
3 NAcc intron excision ratio chr7_132787050_132796079 0.01 0.01 9.6e-03 0.01 0.01 0.01 0.01 5.7e-03 1.1e-02 2.8e-02 1.1e-02
4 Liver alternative TSS XM_006257354.5 0.05 0.05 1.2e-05 0.04 0.04 0.04 0.03 6.7e-05 7.6e-05 4.6e-05 1.0e-04
5 Liver alternative TSS NM_001191615.3 0.05 0.05 1.9e-05 0.04 0.03 0.04 0.03 8.6e-05 1.0e-04 6.4e-05 1.1e-04
6 Adipose gene expression Lima1 0.09 0.08 2.2e-09 0.07 0.07 0.07 0.07 7.0e-08 2.9e-08 7.6e-08 7.5e-08
7 Eye gene expression Lima1 0.35 0.19 5.2e-05 0.31 0.3 0.3 0.28 9.9e-06 1.5e-05 1.4e-05 3.5e-05
8 Liver isoform ratio NM_001191615.3 0.04 0.04 1.9e-04 0.03 0.03 0.03 0.03 4.1e-04 5.4e-04 3.3e-04 6.0e-04
9 Liver isoform ratio XM_006257354.5 0.04 0.04 2.8e-04 0.03 0.02 0.03 0.02 7.0e-04 9.4e-04 5.9e-04 1.0e-03
10 Liver intron excision ratio chr7_132846524_132880254 0.05 0.05 1.1e-04 0.03 0.03 0.03 0.03 1.7e-04 2.8e-04 8.6e-04 3.5e-04
11 Brain mRNA stability Lima1 0.04 0.05 5.6e-03 0.03 0.02 0.01 0.03 1.8e-03 7.2e-03 4.2e-02 1.8e-03
12 NAcc intron excision ratio chr7_132787050_132789811 0.03 0.04 3.0e-03 0.01 0.01 -0 0.01 5.5e-03 2.8e-02 9.7e-01 1.9e-02
13 Liver gene expression Lima1 0.03 0.03 3.2e-03 0.01 0.01 0.01 0.01 6.8e-03 1.4e-02 1.0e-02 1.1e-02
14 Liver intron excision ratio chr7_132846524_132864576 0.05 0.06 8.8e-05 0.04 0.03 0.04 0.03 4.7e-05 1.1e-04 3.4e-05 1.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density6.210.713.5-3.7-3.5-3.63.4-3.4-3.4-3.4-3.23.2-3.23.43.4-3.31.1
Area under the delay curve1.01.22.6-1.1-1.1-1.31.1-1.1-1.1-0.9-1.11.1-1.10.90.9-1.60.4
BMI with tail5.920.426.5-4.9-4.8-5.14.7-4.6-4.7-4.6-4.54.5-4.54.64.6-4.12.4
BMI without tail1.54.65.6-2.3-2.3-2.42.2-2.2-2.2-2.2-2.12.1-2.22.22.2-1.81.3
Body weight6.327.631.7-5.6-5.6-5.65.4-5.4-5.5-5.3-5.35.3-5.35.55.5-4.73.1
Weight adjusted by age0.50.82.1-1.1-1.0-1.40.8-0.8-0.9-1.0-0.70.7-0.71.01.0-0.6-0.5
Bone surface8.114.718.4-4.3-4.2-4.24.0-4.0-4.0-3.8-3.93.9-3.93.73.7-3.81.5
Bone volume7.613.616.1-4.0-3.9-3.73.9-3.9-3.8-3.7-3.73.7-3.73.63.6-3.81.9
Breakpoint value in progressive ratio session0.50.61.0-1.0-0.9-1.00.7-0.7-0.8-1.0-0.60.6-0.61.01.0-0.50.1
Number of licking bursts0.81.42.11.11.11.5-1.11.11.11.31.0-1.01.0-1.2-1.21.3-0.9
Context. condit. distance diff. score0.20.30.4-0.6-0.6-0.30.6-0.6-0.6-0.5-0.60.6-0.60.50.5-0.40.4
Locomotion velocity, session 14.14.55.91.92.01.6-2.32.32.11.92.2-2.22.2-2.0-2.02.1-2.4
Locomotion distance, session 12.83.64.02.02.01.8-2.02.02.01.81.9-1.91.9-2.0-2.01.9-1.3
Locomotion velocity, session 20.30.40.50.60.60.4-0.70.70.60.50.7-0.70.7-0.5-0.50.6-0.5
Locomotion distance, session 22.83.94.52.12.11.7-2.12.12.11.92.1-2.12.1-2.0-2.02.0-1.4
Locomotion velocity, session 34.85.46.02.42.42.4-2.52.42.42.42.3-2.32.3-2.3-2.32.3-1.5
Locomotion distance, session 32.72.94.12.01.92.0-1.81.81.91.61.7-1.71.7-1.6-1.61.7-0.3
Stereotopy head waving bouts, day 30.10.11.1-0.3-0.2-0.6-0.00.0-0.1-0.30.0-0.00.00.20.2-0.1-1.0
Stereotopy head waving duration, day 30.10.21.5-0.10.0-0.4-0.30.30.10.00.3-0.30.3-0.0-0.00.1-1.2
Locomotion velocity, session 72.83.04.41.61.71.2-1.91.91.71.61.9-1.91.9-1.5-1.51.8-2.1
Locomotion distance, session 73.64.65.22.12.21.9-2.32.32.22.22.2-2.22.2-2.0-2.02.2-1.8
Stereotopy head waving bouts, day 70.70.81.1-1.0-1.0-0.90.9-0.9-1.0-0.8-0.80.8-0.80.80.8-1.00.1
Stereotopy head waving duration, day 70.91.11.5-1.2-1.2-1.11.1-1.1-1.1-1.1-1.01.0-1.01.11.1-1.20.4
Locomotion velocity, session 80.50.51.40.50.60.5-0.80.80.70.50.9-0.90.9-0.5-0.50.7-1.2
Locomotion distance, session 81.11.51.81.31.31.3-1.21.21.31.31.2-1.21.2-1.3-1.31.3-0.7
Degree of sensitization distance0.00.00.3-0.2-0.1-0.30.1-0.0-0.10.1-0.00.0-0.0-0.0-0.00.0-0.6
Degree of sensitization stereotypy0.60.60.9-0.7-0.8-0.50.8-0.8-0.8-0.7-0.80.8-0.80.70.7-1.00.8
Conditioned locomotion0.10.10.20.20.20.3-0.20.20.30.40.2-0.20.2-0.4-0.40.2-0.5
Cocaine response after cond. corrected0.00.00.00.10.1-0.1-0.00.10.1-0.00.1-0.10.1-0.0-0.00.00.0
Cocaine response after cond. not corrected0.20.30.40.60.60.6-0.50.50.60.40.5-0.50.5-0.4-0.40.5-0.0
Cocaine response before conditioning1.92.33.71.71.71.9-1.51.51.61.51.4-1.41.4-1.5-1.51.5-0.4
Saline control response0.00.00.10.10.10.2-0.20.20.10.10.2-0.20.1-0.1-0.10.3-0.4
Bone: connectivity density3.14.87.0-2.6-2.4-2.62.2-2.2-2.3-2.2-2.12.1-2.12.22.2-2.20.2
Bone: cortical apparent density0.10.20.30.50.50.3-0.50.50.50.20.5-0.50.5-0.3-0.30.3-0.1
Bone: cortical area5.88.911.9-3.5-3.3-3.43.1-3.1-3.2-3.1-2.92.9-2.92.92.9-3.00.7
Bone: cortical porosity0.20.21.4-0.0-0.10.40.4-0.4-0.20.0-0.50.5-0.50.10.1-0.01.2
Bone: cortical porosity0.10.11.10.20.10.50.2-0.20.00.2-0.20.2-0.2-0.1-0.10.11.1
Bone: cortical thickness1.72.94.0-2.0-1.9-1.81.7-1.7-1.8-1.8-1.61.6-1.61.71.7-1.80.2
Bone: cortical thickness0.20.20.60.30.40.0-0.50.50.40.20.5-0.50.5-0.3-0.30.6-0.7
Bone: cortical tissue density0.20.30.40.60.60.4-0.60.60.60.30.6-0.60.6-0.4-0.40.4-0.2
Condit. Reinf. active minus inactive responses0.10.10.30.30.30.5-0.20.20.30.30.2-0.20.2-0.4-0.40.4-0.0
Condit. Reinf. active-inactive response ratio0.10.20.3-0.5-0.5-0.30.5-0.5-0.4-0.3-0.50.5-0.50.20.2-0.30.1
Condit. Reinf. active responses0.70.81.11.00.91.0-0.90.90.90.80.9-0.90.9-0.9-0.91.0-0.4
Condit. Reinf. inactive responses2.53.13.81.91.91.8-2.01.91.91.51.9-1.91.9-1.6-1.61.8-0.9
Incentive salience index mean0.00.00.0-0.1-0.10.20.1-0.1-0.1-0.1-0.10.1-0.1-0.1-0.10.00.2
Condit. Reinf. lever presses0.40.50.8-0.7-0.7-0.50.8-0.8-0.7-0.8-0.80.8-0.80.70.7-0.60.9
Condit. Reinf. active minus inactive responses0.81.12.6-0.8-0.9-0.31.2-1.2-1.0-0.8-1.11.1-1.10.90.9-1.21.6
Condit. Reinf. active-inactive response ratio0.70.83.0-0.5-0.7-0.11.0-1.0-0.8-0.6-0.90.9-0.90.70.7-1.11.7
Condit. Reinf. active responses0.10.21.0-0.1-0.20.20.4-0.4-0.3-0.3-0.40.4-0.40.30.3-0.41.0
Condit. Reinf. inactive responses0.60.81.10.90.90.9-1.01.00.90.71.0-1.01.0-0.8-0.81.0-0.5
Condit. Reinf. lever presses0.00.00.1-0.1-0.1-0.0-0.10.1-0.1-0.30.1-0.10.00.30.30.0-0.0
Condit. Reinf. lever reinforcers received0.00.10.50.20.20.6-0.00.00.10.1-0.00.0-0.0-0.1-0.10.00.7
Conditioned reinforcement - actives0.40.61.11.11.00.7-0.90.80.90.60.8-0.80.7-0.6-0.60.8-0.1
Conditioned reinforcement - inactives3.85.56.62.62.52.5-2.52.52.52.32.3-2.32.3-2.3-2.32.3-1.3
Conditioned locomotion0.30.30.80.60.60.7-0.50.50.60.90.5-0.50.5-0.7-0.7-0.0-0.7
Patch foraging indifference point 0 sec5.39.711.33.03.13.1-3.23.13.13.33.1-3.13.0-3.4-3.43.1-2.7
Patch foraging indifference point AUC0.60.81.21.11.11.1-1.01.01.00.81.0-1.01.0-0.8-0.80.7-0.2
Delay disc. indifference point, 0s delay1.92.12.5-1.5-1.5-1.31.6-1.6-1.5-1.4-1.51.6-1.51.41.4-1.31.3
Delay disc. indifference point, 16s delay0.70.81.7-0.9-0.9-1.20.9-0.9-0.9-0.8-0.90.9-0.90.90.9-1.30.3
Delay disc. indifference point, 2s delay1.82.03.3-1.5-1.5-1.61.5-1.5-1.4-1.2-1.51.5-1.51.31.3-1.80.6
Delay disc. indifference point, 24s delay0.40.51.2-0.8-0.7-0.80.7-0.7-0.7-0.6-0.60.6-0.70.50.5-1.1-0.3
Delay disc. indifference point, 4s delay1.41.52.9-1.1-1.1-1.21.3-1.3-1.2-1.1-1.21.2-1.21.11.1-1.70.9
Delay disc. indifference point, 8s delay1.11.32.3-1.2-1.2-1.51.1-1.1-1.1-1.0-1.11.1-1.11.11.1-1.30.1
Indifference point function ln k3.76.57.5-2.7-2.6-2.52.7-2.7-2.6-2.5-2.62.6-2.62.52.5-2.51.7
Indifference point function log k3.76.57.5-2.7-2.6-2.52.7-2.7-2.6-2.5-2.62.6-2.62.52.5-2.51.7
Patch foraging total patch changes 0 sec4.89.110.52.93.03.1-3.03.03.03.23.0-3.03.0-3.2-3.22.9-2.6
Patch foraging total patch changes 12 sec6.38.18.82.82.92.7-3.02.92.92.92.9-2.92.9-3.0-3.02.7-2.5
Patch foraging total patch changes 18 sec5.68.610.23.13.13.2-3.03.03.02.93.0-3.03.1-2.9-2.92.8-1.8
Patch foraging total patch changes 24 sec3.35.66.82.42.42.6-2.42.42.42.52.4-2.32.4-2.5-2.52.3-1.6
Patch foraging total patch changes 6 sec6.910.511.43.13.23.1-3.33.33.23.33.3-3.23.3-3.4-3.43.1-3.0
Patch foraging time to switch 0 sec1.93.84.52.12.11.9-2.12.12.01.82.0-2.02.1-1.8-1.82.1-1.1
Patch foraging water rate 0 sec2.75.76.7-2.6-2.6-2.32.6-2.6-2.5-2.2-2.52.5-2.52.22.2-2.51.5
Patch foraging water rate 12 sec1.94.05.0-2.2-2.1-2.22.2-2.2-2.1-1.9-2.12.1-2.11.81.8-1.91.0
Patch foraging water rate 18 sec0.40.60.9-0.8-0.8-0.80.9-0.9-0.8-0.6-0.90.9-1.00.50.5-0.90.4
Patch foraging water rate 24 sec4.76.67.2-2.6-2.6-2.62.6-2.6-2.6-2.6-2.62.6-2.62.72.7-2.41.7
Patch foraging water rate 6 sec6.08.710.2-3.1-3.1-2.83.2-3.2-3.1-2.9-3.13.0-3.02.92.9-3.02.1
Seeking ratio, delayed vs. immediate footshock0.40.50.9-0.6-0.7-0.40.8-0.8-0.7-0.6-0.80.8-0.80.50.5-0.31.0
Distance traveled before self-admin2.22.84.31.61.61.5-1.71.71.71.91.7-1.71.7-1.6-1.61.3-2.1
Distance traveled after self-admin1.21.51.71.11.21.2-1.21.21.21.31.2-1.21.2-1.2-1.21.2-1.3
Extensor digitorum longus weight4.618.021.2-4.4-4.4-4.34.3-4.3-4.4-4.6-4.14.1-4.14.54.5-4.22.7
Bone: elastic displacement6.27.28.22.72.72.3-2.92.92.82.62.8-2.82.8-2.7-2.72.7-2.1
Bone: elastic work0.10.10.40.10.1-0.2-0.30.30.20.00.3-0.30.3-0.2-0.20.2-0.6
Bone: endosteal estimation6.614.417.6-4.2-4.1-4.24.0-4.0-4.0-3.8-3.93.9-3.93.63.6-3.71.7
Bone: endosteal perimeter6.113.015.3-3.9-3.9-3.83.8-3.8-3.8-3.6-3.63.6-3.73.53.5-3.61.9
Epididymis fat weight0.20.71.7-1.1-1.0-1.30.8-0.8-1.0-0.9-0.70.7-0.70.90.9-0.3-0.3
Delta time in closed arm before/after self-admin0.10.00.4-0.0-0.00.40.1-0.1-0.10.0-0.10.1-0.10.00.00.10.6
Delta time in open arm before/after self-admin1.11.11.31.11.11.0-1.11.11.11.01.1-1.11.1-1.0-1.00.8-0.9
Diff in mean of infusions in LGA sessions0.60.71.2-1.0-1.0-1.10.8-0.8-0.9-0.9-0.80.8-0.90.70.7-1.0-0.1
Delay discount exponential model param1.11.22.81.01.01.3-1.11.11.10.91.1-1.11.1-0.9-0.91.7-0.3
Extinction: sum of active levers before priming2.02.22.8-1.7-1.7-1.51.6-1.6-1.6-1.5-1.61.6-1.61.41.4-0.81.0
Active lever presses in extinction session 60.10.10.5-0.5-0.4-0.50.2-0.2-0.3-0.3-0.10.1-0.20.30.3-0.1-0.7
Bone: final force10.717.219.9-4.5-4.4-4.34.3-4.3-4.3-4.2-4.24.2-4.24.14.1-4.22.2
Bone: final moment12.119.422.3-4.7-4.7-4.64.6-4.6-4.6-4.5-4.44.4-4.44.44.4-4.52.4
Food consumed during 24 hour testing period1.52.02.5-1.5-1.5-1.11.6-1.6-1.5-1.3-1.61.6-1.61.41.4-1.40.8
Glucose0.60.93.40.60.60.4-0.90.90.71.00.9-0.90.9-1.0-1.00.7-1.8
Heart weight0.20.20.3-0.5-0.5-0.60.5-0.5-0.6-0.4-0.50.5-0.50.50.5-0.30.4
Delay discount hyperbolic model param1.01.22.71.11.01.3-1.11.11.10.91.1-1.11.1-0.9-0.91.6-0.3
Intermittent access intake day 1-15 change0.10.21.1-0.2-0.2-0.40.4-0.4-0.3-0.6-0.40.4-0.20.60.6-0.11.0
Intermittent access intake escalation0.30.72.1-0.5-0.6-0.70.8-0.8-0.7-1.0-0.80.8-0.61.01.0-0.41.5
Intermittent access intake escalation 20.10.21.1-0.1-0.1-0.20.3-0.3-0.2-0.5-0.30.3-0.20.60.60.11.0
Intermitt. access day 1 inactive lever presses0.00.10.30.50.40.5-0.20.20.40.20.2-0.20.2-0.3-0.3-0.10.3
Intermitt. access day 15 inactive lever presses0.10.22.40.30.10.30.2-0.20.0-0.1-0.20.2-0.3-0.0-0.00.11.5
Intermitt. access escalation Index0.10.10.4-0.3-0.3-0.40.2-0.2-0.2-0.0-0.20.2-0.2-0.0-0.0-0.1-0.6
Intermittent access day 1 total infusions0.91.52.21.41.31.4-1.21.21.31.51.1-1.21.0-1.4-1.40.6-1.0
Intermittent access day 15 total infusions0.30.50.90.90.90.8-0.70.70.80.70.7-0.70.6-0.6-0.60.50.0
Intermittent access terminal intake (last 3 days)0.50.71.21.11.01.0-0.80.80.90.70.8-0.80.7-0.7-0.70.60.0
Intermittent access total infusions1.11.31.91.41.31.3-1.21.11.21.21.1-1.11.0-1.1-1.10.8-0.4
Intermittent access day 1 locomotion0.81.02.30.91.00.8-1.01.01.11.20.9-0.90.9-1.1-1.10.1-1.5
Intermittent access day 15 total locomotion0.30.50.70.70.70.8-0.70.70.70.80.6-0.60.6-0.8-0.8-0.1-0.8
Intermittent access total locomotion2.02.43.11.71.71.7-1.61.61.71.81.5-1.51.5-1.6-1.60.8-1.4
Intermittent access standard deviation0.00.10.20.40.40.0-0.30.30.40.10.3-0.30.3-0.0-0.00.40.3
Left kidney weight1.46.57.1-2.6-2.6-2.52.6-2.6-2.7-2.5-2.62.6-2.72.62.6-2.02.3
Right kidney weight4.018.222.8-4.6-4.5-4.84.4-4.4-4.5-4.3-4.34.3-4.34.44.4-3.72.5
Cocaine induced anxiety1.92.74.2-1.8-1.8-2.11.6-1.6-1.7-1.8-1.61.6-1.61.81.8-1.30.6
Post-drug Anxiety3.33.65.1-2.0-2.0-2.31.9-1.9-2.0-2.0-1.91.9-1.91.91.9-1.31.1
Baseline Anxiety0.30.30.8-0.5-0.6-0.40.7-0.7-0.6-0.4-0.70.7-0.70.40.4-0.30.9
Tail length0.00.00.1-0.0-0.00.30.0-0.0-0.10.2-0.00.0-0.1-0.1-0.10.10.1
Length with tail1.46.07.2-2.7-2.7-2.52.6-2.6-2.6-2.4-2.52.5-2.52.52.5-2.21.5
Length without tail5.216.919.7-4.4-4.4-4.34.3-4.3-4.3-4.1-4.14.1-4.14.24.2-4.02.2
Times rat made contact with spout0.00.00.30.10.10.5-0.10.10.1-0.00.1-0.10.1-0.0-0.00.00.2
Lifetime Intake1.82.23.11.81.71.7-1.61.51.61.61.5-1.51.4-1.5-1.50.9-0.7
Liver weight, left9.515.818.1-4.2-4.2-4.14.2-4.2-4.2-3.7-4.14.1-4.13.93.9-3.92.3
Liver weight, right3.25.56.2-2.5-2.4-2.42.5-2.5-2.4-2.3-2.52.4-2.42.42.4-1.81.7
Locomotor activity1.21.93.01.51.41.5-1.51.51.41.31.4-1.41.4-1.3-1.31.7-0.8
Locomotor testing distance2.95.36.52.42.42.5-2.42.42.32.32.3-2.32.3-2.3-2.32.6-1.3
Locomotor testing rearing1.63.34.42.01.92.0-1.91.91.91.71.8-1.81.8-1.6-1.62.1-0.8
Locomotion in novel chamber4.55.86.8-2.3-2.3-2.12.5-2.5-2.4-2.5-2.42.4-2.42.62.6-2.42.4
Locomotion in novel chamber post-restriction0.20.31.0-0.4-0.4-0.30.6-0.6-0.5-0.5-0.60.6-0.60.60.6-0.41.0
Fecal boli incidents, locomotor time 10.81.22.21.21.11.1-1.01.01.11.40.9-0.90.9-1.5-1.50.6-0.5
Change in fecal boli incidents, locomotor task0.10.10.3-0.4-0.4-0.50.2-0.2-0.3-0.5-0.20.2-0.20.60.6-0.2-0.4
Time >=10cm from walls, locomotor time 10.60.62.40.50.60.2-0.80.80.70.80.8-0.80.8-0.9-0.90.6-1.6
Bouts of movement, locomotor time 10.00.00.10.00.00.1-0.00.00.0-0.00.0-0.00.0-0.2-0.20.30.2
Total resting periods, locomotor time 10.40.51.00.70.70.7-0.70.70.70.60.7-0.70.7-0.8-0.81.0-0.3
Rest time, locomotor task time 10.70.91.60.90.91.1-1.01.00.90.90.9-0.90.9-0.8-0.81.3-0.4
Distance moved, locomotor task time 10.00.00.10.00.00.1-0.00.00.10.10.0-0.00.00.20.2-0.3-0.2
Vertical activity count, locomotor time 10.41.01.5-1.1-1.1-1.21.0-1.0-1.0-1.0-1.01.0-1.01.01.0-1.10.2
Time >=10cm from walls, locomotor time 20.30.50.60.80.80.5-0.80.80.70.70.7-0.70.7-0.8-0.80.7-0.4
Bouts of movement, locomotor time 22.53.94.9-2.1-2.1-1.72.2-2.2-2.1-1.9-2.12.1-2.11.81.8-2.01.6
Total resting periods, locomotor time 22.54.35.3-2.2-2.2-1.82.3-2.3-2.2-1.9-2.22.2-2.21.91.9-2.01.7
Rest time, locomotor task time 20.20.30.90.40.40.7-0.50.50.40.60.5-0.50.5-0.5-0.50.9-0.4
Distance moved, locomotor task time 20.00.00.10.20.2-0.1-0.20.20.30.10.2-0.20.20.10.1-0.1-0.2
Vertical activity count, locomotor time 20.10.20.3-0.3-0.3-0.50.4-0.4-0.3-0.5-0.40.4-0.40.50.5-0.60.4
Light reinforcement 10.71.83.61.61.51.9-1.21.21.31.41.2-1.21.2-1.4-1.41.30.5
Light reinforcement 20.10.21.60.20.10.60.2-0.20.00.1-0.10.1-0.20.00.0-0.41.3
Bone: marrow area6.213.416.6-4.1-4.0-4.13.8-3.8-3.8-3.6-3.73.7-3.73.53.5-3.61.5
Bone: maximum diameter1.52.84.4-2.0-1.9-2.11.7-1.7-1.8-1.7-1.61.6-1.61.61.6-1.60.1
Bone: maximum force13.724.329.2-5.4-5.3-5.35.1-5.1-5.1-5.1-5.05.0-4.94.94.9-5.02.3
Bone: maximum moment15.326.932.0-5.7-5.5-5.65.4-5.4-5.4-5.3-5.25.2-5.25.15.1-5.22.5
Mean time between licks in bursts0.00.10.10.30.30.1-0.40.40.40.20.4-0.40.4-0.2-0.20.4-0.2
Mean num. licks in bursts0.40.61.0-0.6-0.7-0.70.7-0.7-0.7-1.0-0.60.6-0.60.80.8-1.00.8
Cd content in liver0.20.30.50.60.60.7-0.50.40.50.60.4-0.40.4-0.6-0.60.60.1
Co content in liver0.30.30.40.60.60.5-0.60.60.60.50.6-0.60.6-0.5-0.50.4-0.2
Cu content in liver0.10.20.4-0.6-0.5-0.50.3-0.3-0.4-0.3-0.40.4-0.40.30.3-0.1-0.6
Fe content in liver1.62.02.41.51.51.5-1.51.51.51.31.5-1.51.5-1.3-1.31.3-0.7
K content in liver0.20.20.40.30.40.2-0.40.40.40.20.4-0.50.4-0.2-0.20.6-0.5
Mg content in liver0.10.10.30.40.40.6-0.30.30.40.30.3-0.30.3-0.3-0.30.50.1
Mn content in liver0.00.00.10.10.10.1-0.00.00.10.10.0-0.00.1-0.1-0.10.3-0.1
Na content in liver0.00.00.10.00.0-0.00.0-0.00.0-0.10.1-0.1-0.00.10.10.00.3
Rb content in liver1.61.93.61.11.21.2-1.41.41.31.41.3-1.31.3-1.3-1.31.4-1.9
Se content in liver3.74.44.92.12.11.9-2.22.22.12.12.1-2.12.2-2.1-2.12.2-1.7
Sr content in liver0.60.50.7-0.8-0.8-0.70.7-0.7-0.7-0.7-0.70.7-0.70.70.7-0.70.1
Zn content in liver0.70.81.31.01.01.2-0.80.81.00.90.8-0.80.9-0.9-0.91.1-0.1
Bone: minimum diameter7.613.816.8-4.1-4.0-3.93.9-3.9-3.9-3.7-3.83.8-3.83.63.6-3.71.8
Time in familiar zone, hab. session 10.00.00.30.1-0.00.20.1-0.1-0.1-0.2-0.10.1-0.10.20.2-0.20.5
Time in novel zone, hab. session 10.00.00.1-0.2-0.2-0.20.1-0.1-0.10.1-0.20.2-0.2-0.1-0.1-0.0-0.4
Total zone transitions, hab. session 10.10.10.10.40.30.3-0.20.20.30.20.2-0.20.2-0.3-0.30.20.2
Total locomotion distance, hab. session 10.30.41.20.50.50.2-0.60.60.60.60.6-0.60.6-0.6-0.60.7-1.1
Locomotion velocity, hab. session 10.20.20.80.30.40.1-0.50.50.50.40.5-0.50.5-0.5-0.50.5-0.9
Time in familiar zone, hab. session 21.61.61.9-1.2-1.2-1.01.3-1.3-1.3-1.3-1.31.3-1.31.31.3-1.31.4
Time in novel zone, hab. session 21.71.82.61.21.21.0-1.41.31.31.51.3-1.31.3-1.4-1.41.4-1.6
Total zone transitions, hab. session 20.20.20.30.50.50.5-0.50.50.50.30.5-0.50.5-0.4-0.40.5-0.1
Total locomotion distance, hab. session 20.30.40.50.60.70.5-0.70.70.70.60.7-0.70.7-0.6-0.60.7-0.6
Locomotion velocity, hab. session 20.20.20.30.40.50.4-0.50.50.50.30.5-0.50.5-0.4-0.40.5-0.5
Novel to familiar place preference ratio1.21.31.7-1.3-1.3-1.01.3-1.3-1.3-0.8-1.21.2-1.20.90.9-1.20.4
Novelty place preference0.70.71.1-1.0-1.0-0.71.0-1.0-1.0-0.5-1.01.0-1.00.60.6-0.90.2
Time in novel zone, NPP test0.40.50.8-0.9-0.8-0.50.8-0.8-0.8-0.3-0.80.8-0.80.40.4-0.7-0.0
Total zone transitions, NPP test2.63.74.11.91.91.8-2.02.02.01.92.0-2.02.0-2.0-2.02.0-1.7
Total locomotion distance, NPP test3.44.65.12.12.22.0-2.22.22.22.22.2-2.22.2-2.1-2.12.2-1.9
Locomotion velocity, NPP test2.23.13.41.71.81.6-1.91.81.81.81.8-1.81.8-1.7-1.71.8-1.7
Intraocular pressure5.27.59.63.13.03.1-2.82.82.92.72.7-2.72.7-2.7-2.72.8-0.8
Delta distance traveled before/after self-admin0.10.10.3-0.1-0.10.10.2-0.2-0.1-0.3-0.20.2-0.20.40.40.10.6
Delta ambulatory time before/after self-admin0.00.10.40.10.10.30.0-0.00.1-0.1-0.00.0-0.00.10.10.50.7
Parametrial fat weight0.40.91.61.31.21.1-1.01.01.10.71.0-1.01.1-0.7-0.70.80.1
Pavlov. Cond. lever latency0.20.31.70.20.30.0-0.40.40.40.60.4-0.40.4-0.4-0.40.3-1.3
Pavlov. Cond. magazine entry latency1.11.43.9-0.9-1.0-0.71.3-1.3-1.1-1.1-1.31.3-1.31.01.0-1.02.0
Pavlov. Cond. change in total contacts1.41.53.7-0.9-1.1-0.81.3-1.3-1.2-1.3-1.21.2-1.21.11.1-1.21.9
Pavlov. Cond. index score0.91.13.0-0.8-0.9-0.61.1-1.1-1.0-1.1-1.11.1-1.10.90.9-0.91.7
Pavlov. Cond. latency score0.70.92.8-0.7-0.8-0.51.0-1.0-0.9-1.0-1.01.0-1.00.80.8-0.81.7
Pavlov. Cond. lever contacts0.20.32.2-0.0-0.20.10.4-0.4-0.3-0.5-0.40.4-0.40.30.3-0.31.5
Pavlov. Cond. magazine entry number0.50.71.80.60.70.5-0.90.90.80.80.9-0.90.9-0.6-0.60.7-1.3
Pavlov. Cond. intertrial magazine entries5.06.010.32.12.21.6-2.62.62.42.32.5-2.52.5-2.4-2.42.4-3.2
Pavlov. Cond. lever-magazine prob. diff.1.21.52.9-1.0-1.1-0.91.3-1.3-1.2-1.3-1.31.3-1.31.11.1-1.11.7
Pavlov. Cond. response bias0.30.41.8-0.3-0.4-0.20.6-0.6-0.6-0.6-0.70.7-0.70.40.4-0.51.3
Pavlov. Cond. lever latency0.91.31.8-1.0-1.1-1.01.3-1.3-1.1-0.9-1.31.3-1.30.90.9-1.11.4
Pavlov. Cond. magazine entry latency0.30.43.40.00.2-0.3-0.60.60.30.50.5-0.50.5-0.4-0.40.4-1.9
Pavlov. Cond. change in total contacts0.40.61.0-1.0-0.9-0.80.8-0.8-0.9-0.8-0.80.8-0.80.90.9-0.8-0.1
Pavlov. Cond. index score0.40.53.20.30.40.1-0.80.80.50.50.7-0.70.7-0.4-0.40.6-1.8
Pavlov. Cond. latency score0.50.63.40.30.50.2-0.80.80.60.60.8-0.80.8-0.5-0.50.7-1.8
Pavlov. Cond. lever contacts0.71.01.70.80.90.8-1.11.10.90.81.1-1.11.1-0.8-0.81.0-1.3
Pavlov. Cond. magazine entry number0.20.33.30.40.20.60.2-0.20.1-0.1-0.20.2-0.20.00.0-0.01.8
Pavlov. Cond. intertrial magazine entries2.03.05.52.12.02.4-1.61.61.81.71.5-1.51.5-1.7-1.71.80.4
Pavlov. Cond. lever-magazine prob. diff.0.30.43.10.10.2-0.1-0.60.60.40.40.6-0.60.6-0.3-0.30.5-1.8
Pavlov. Cond. response bias0.30.51.40.40.50.4-0.80.80.60.50.8-0.80.7-0.5-0.50.6-1.2
Time in closed arm before self-admin1.41.83.1-1.5-1.4-1.81.2-1.2-1.3-1.4-1.21.2-1.11.61.6-1.40.1
Time in closed arm after self-admin0.30.30.8-0.5-0.5-0.30.5-0.5-0.5-0.6-0.40.4-0.40.90.9-0.40.8
Time in open arm before self-admin0.30.40.70.50.60.6-0.50.50.60.80.5-0.50.5-0.8-0.80.6-0.7
Time in open arm after self-admin0.30.30.60.50.50.2-0.50.50.50.60.5-0.50.5-0.7-0.70.6-0.8
Bone: periosteal estimation9.018.923.7-4.9-4.7-4.84.5-4.5-4.6-4.4-4.44.4-4.44.24.2-4.31.7
Bone: periosteal perimeter8.414.417.7-4.2-4.1-4.14.0-4.0-4.0-3.8-3.83.8-3.93.73.7-3.81.7
Bone: post-yield work6.910.113.9-3.5-3.4-3.73.2-3.2-3.2-3.3-3.13.1-3.13.33.3-3.11.2
Progressive ratio test 1 active lever presses6.58.09.63.13.13.0-3.03.03.02.92.9-2.92.8-2.8-2.82.4-1.9
Progressive ratio test 1 breakpoint6.37.79.23.03.03.0-2.92.93.02.92.8-2.82.7-2.7-2.72.3-1.9
Progressive ratio test 1 inactive lever presses0.30.51.11.10.91.0-0.60.60.80.50.6-0.60.6-0.5-0.50.30.6
Progressive ratio test 2 active lever presses1.21.42.21.51.41.2-1.31.31.41.21.2-1.21.2-1.1-1.10.8-0.7
Progressive ratio test 2 breakpoint1.11.32.01.41.31.1-1.21.21.31.11.1-1.11.1-1.1-1.10.7-0.7
Progressive ratio test 2 inactive lever presses0.30.51.01.00.90.8-0.70.70.80.70.6-0.60.6-0.6-0.60.70.2
Incentive Sensitization - Responses0.60.91.2-0.8-0.8-0.91.0-1.0-0.9-1.0-1.01.0-0.91.11.1-1.00.9
Incentive Sensitization - Breakpoint0.60.70.9-0.7-0.7-0.80.9-0.9-0.8-0.9-0.90.9-0.81.01.0-0.90.9
Sum of active levers in priming session hrs 5-60.10.10.30.20.20.5-0.30.30.20.20.3-0.30.3-0.5-0.50.6-0.4
Progressive ratio1.21.92.71.31.41.0-1.51.51.51.31.4-1.41.4-1.3-1.31.4-1.7
Food seeking constrained by brief footshock3.03.64.51.81.91.4-2.12.12.01.92.0-2.02.0-1.7-1.71.8-2.1
Seeking ratio, punishment vs. effort0.00.00.1-0.2-0.2-0.10.2-0.2-0.2-0.1-0.20.2-0.20.20.2-0.20.4
Retroperitoneal fat weight0.83.34.51.81.81.4-2.02.01.91.71.9-1.91.9-1.7-1.72.1-1.7
Reaction time number correct0.81.62.0-1.4-1.3-1.41.4-1.3-1.2-1.3-1.21.2-1.21.31.3-1.20.6
Reaction time mean minus median3.07.410.23.02.93.2-2.82.82.82.82.7-2.72.7-2.8-2.82.5-0.9
Reaction time mean minus median AUC2.15.26.82.52.52.6-2.42.42.32.42.3-2.32.3-2.3-2.32.1-0.8
Reaction time num false alarms1.31.82.61.41.41.6-1.31.31.41.41.2-1.21.2-1.5-1.51.5-0.3
Reaction time num false alarms AUC1.42.13.11.61.51.8-1.41.41.51.61.3-1.31.3-1.6-1.61.6-0.3
Reaction time trials correct on left0.81.62.0-1.4-1.3-1.41.4-1.3-1.2-1.3-1.21.2-1.21.31.3-1.20.6
Reaction time trials on left0.61.21.6-1.2-1.1-1.21.2-1.2-1.1-1.2-1.11.1-1.11.11.1-1.00.6
Reaction time mean0.61.01.51.01.01.1-1.01.01.01.20.9-0.90.9-1.1-1.11.0-0.5
Reaction time mean AUC0.40.61.00.80.80.9-0.80.80.71.00.7-0.70.7-0.9-0.90.8-0.4
Median of all reaction times0.00.00.20.00.10.1-0.10.10.10.40.1-0.10.1-0.3-0.30.3-0.2
Reaction time omissions7.511.013.33.63.63.4-3.53.53.53.33.4-3.43.3-3.2-3.23.4-1.5
Reaction time false alarm rate1.72.33.41.71.61.8-1.51.51.51.71.4-1.41.4-1.7-1.71.7-0.3
Reaction time premature initiation rate3.24.56.12.52.42.2-2.42.42.21.82.2-2.22.2-1.7-1.72.4-0.4
Reaction time premature initiations1.01.72.71.61.51.3-1.51.51.41.01.4-1.41.4-0.9-0.91.60.0
Std. dev. reaction times3.87.08.92.82.83.0-2.72.72.72.82.6-2.62.6-2.8-2.82.6-1.1
Reaction time trials completed0.61.21.6-1.2-1.1-1.21.2-1.2-1.1-1.2-1.11.1-1.11.11.1-1.00.6
Reaction time trials AUC1.12.12.5-1.6-1.5-1.61.6-1.5-1.4-1.5-1.41.4-1.41.51.5-1.40.7
Run reversals in cocaine runway, females0.80.81.6-0.6-0.6-0.70.8-0.8-0.7-1.0-0.70.7-0.81.21.2-0.81.3
Run reversals in cocaine runway, males0.50.51.10.90.81.1-0.70.70.80.70.7-0.70.7-0.7-0.70.50.1
Latency to leave start box in cocaine runway0.00.00.10.00.00.00.2-0.20.0-0.0-0.30.3-0.2-0.0-0.00.10.3
Latency to leave start box in cocaine runway, F0.70.81.11.11.00.9-0.90.91.00.90.8-0.80.8-1.0-1.00.8-0.5
Latency to leave start box in cocaine runway, M1.81.72.0-1.4-1.4-1.21.4-1.4-1.3-1.3-1.41.4-1.41.31.3-1.01.0
Std. dev. time between licks in bursts1.11.52.01.31.31.4-1.31.31.31.31.2-1.21.2-1.3-1.31.3-0.6
Total sessions with >9 infusions2.02.43.31.81.81.8-1.61.61.71.71.5-1.51.5-1.5-1.50.9-0.8
Short access day 1 total inactive lever presses1.21.62.41.61.51.5-1.31.31.51.21.3-1.31.3-1.1-1.10.8-0.6
Short access day 10 total inactive lever presses0.10.21.1-0.2-0.20.40.4-0.4-0.3-0.3-0.30.3-0.40.10.1-0.01.0
Short access day 1 total infusions1.01.31.71.31.31.3-1.21.21.31.21.1-1.11.1-1.1-1.10.6-0.9
Short access day 10 total infusions1.62.03.11.61.61.8-1.41.41.61.71.4-1.41.3-1.4-1.40.6-0.7
Short access total infusions3.03.84.92.22.22.2-2.02.02.12.12.0-2.01.9-2.0-2.01.2-1.3
Short access day 1 locomotion0.40.40.70.70.70.8-0.60.60.70.80.6-0.60.6-0.5-0.5-0.6-0.7
Short access day 10 total locomotion0.20.40.50.70.70.6-0.60.60.70.70.6-0.60.6-0.6-0.60.0-0.7
Short access total locomotion0.91.01.61.21.11.3-1.01.01.11.21.0-1.01.0-0.9-0.90.1-0.7
One hour access (0.3 mA shock)0.30.41.6-0.3-0.4-0.30.6-0.6-0.5-0.6-0.60.6-0.60.60.6-0.81.3
Compulsive drug intake0.40.41.3-0.5-0.6-0.30.7-0.7-0.6-0.8-0.60.7-0.50.50.5-0.71.1
One hour access (shock baseline)0.20.30.7-0.3-0.4-0.40.5-0.5-0.5-0.5-0.50.5-0.60.70.7-0.60.8
Social response proportion0.10.10.30.50.40.5-0.40.40.40.40.3-0.30.3-0.4-0.40.4-0.2
Social responses4.86.19.02.82.73.0-2.52.52.52.52.3-2.32.3-2.5-2.52.8-0.7
Social time0.40.50.7-0.6-0.7-0.70.7-0.7-0.7-0.8-0.80.8-0.80.70.7-0.20.8
Soleus weight0.92.63.1-1.6-1.6-1.61.7-1.6-1.6-1.8-1.51.5-1.51.61.6-1.71.3
Bone: stiffness18.930.734.5-5.9-5.8-5.75.8-5.8-5.7-5.7-5.65.6-5.65.65.6-5.63.2
Tibialis anterior weight2.89.711.9-2.9-3.0-2.63.1-3.1-3.2-3.4-3.03.0-3.03.33.3-3.13.1
Time to tail flick, vehicle, before self-admin1.31.44.31.21.21.1-1.21.21.10.91.2-1.21.2-1.0-1.02.1-0.2
Time to tail flick, vehicle, after self-admin0.30.40.7-0.5-0.5-0.80.4-0.4-0.6-0.9-0.40.4-0.40.90.9-0.70.3
Time to tail flick, test, before self-admin0.20.20.60.50.50.1-0.50.40.50.40.4-0.40.4-0.2-0.20.8-0.3
Time to tail flick, test, after self-admin1.21.32.1-1.1-1.1-1.21.1-1.1-1.1-1.1-1.01.0-1.01.41.4-1.01.0
Delta time to tail flick, vehicle, before/after SA0.70.71.9-0.8-0.8-0.80.7-0.7-0.8-0.8-0.70.7-0.70.90.9-1.40.3
Delta time to tail flick, test, before/after SA0.60.61.1-0.8-0.8-0.40.8-0.8-0.8-0.7-0.70.7-0.70.70.7-1.00.9
Tibia length4.111.315.2-3.9-3.8-3.73.5-3.5-3.6-3.3-3.43.4-3.43.23.2-3.20.9
Ambulatory time before self-admin2.43.54.21.91.91.8-2.02.01.92.11.9-1.91.9-1.9-1.91.4-1.9
Ambulatory time after self-admin1.82.23.11.51.51.8-1.51.51.51.51.4-1.41.5-1.5-1.51.5-0.9
Bone: tissue strength1.41.51.8-1.3-1.3-1.31.2-1.2-1.3-1.2-1.21.2-1.21.21.2-1.30.4
Total heroin consumption0.40.50.7-0.8-0.8-0.70.7-0.7-0.8-0.6-0.70.7-0.70.60.6-0.60.0
Bone: trabecular number3.45.67.4-2.7-2.6-2.72.5-2.4-2.5-2.3-2.32.3-2.32.42.4-2.40.5
Bone: trabecular spacing1.11.52.41.41.31.6-1.21.21.21.31.1-1.11.1-1.4-1.51.2-0.1
Bone: trabecular thickness0.50.62.2-0.5-0.5-0.30.8-0.8-0.6-0.8-0.70.7-0.70.90.9-0.81.5
Bone: trabecular tissue density0.91.43.6-0.9-1.0-0.41.3-1.3-1.1-1.0-1.21.2-1.21.11.1-1.31.9
Water consumed over 24 hours0.00.00.0-0.1-0.10.20.1-0.1-0.1-0.2-0.10.1-0.10.20.2-0.1-0.1
Number of responses in last shaping day0.10.10.60.0-0.00.20.3-0.2-0.0-0.1-0.20.2-0.20.30.3-0.80.6