Lima1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	XM_006257354.4	0.05	0.05	1.0e-05	0.04	0.04	0.04	0.04	8.9e-05	3.4e-05	2.7e-05	5.2e-05
2	Liver	gene expression	Lima1	0.03	0.03	8.3e-04	0.02	0.02	0.02	0.01	5.3e-03	2.9e-03	6.3e-03	7.4e-03
3	Adipose	gene expression	Lima1	0.09	0.08	2.7e-09	0.06	0.07	0.06	0.06	9.9e-08	4.7e-08	1.2e-07	1.1e-07
4	Liver	isoform ratio	XM_006257354.4	0.05	0.05	2.2e-05	0.03	0.04	0.04	0.03	9.4e-05	8.7e-05	4.3e-05	1.0e-04
5	Liver	alternative TSS	NM_001191615.3	0.05	0.05	2.2e-05	0.03	0.04	0.04	0.03	1.9e-04	5.8e-05	7.6e-05	1.3e-04
6	Liver	isoform ratio	NM_001191615.3	0.05	0.05	3.6e-05	0.03	0.03	0.04	0.03	1.2e-04	1.2e-04	6.2e-05	1.2e-04
7	NAcc	intron excision ratio	chr7_130908211_130917240	0.03	0.03	5.7e-03	0.02	0.02	0.02	0.02	2.4e-03	5.5e-03	3.7e-03	2.1e-03
8	Liver	intron excision ratio	chr7_130967692_130985745	0.04	0.05	2.6e-04	0.03	0.03	0.03	0.03	9.5e-05	2.9e-04	1.6e-04	2.2e-04
9	Liver	intron excision ratio	chr7_130967692_131001423	0.04	0.04	2.3e-04	0.04	0.03	0.03	0.03	8.3e-05	5.3e-04	2.6e-04	1.9e-04
10	Brain	gene expression	Lima1	0.06	0.05	1.1e-05	0.06	0.06	0.06	0.06	6.4e-06	2.9e-06	2.0e-06	3.1e-06
11	Eye	gene expression	Lima1	0.35	0.2	8.2e-05	0.36	0.26	0.35	0.35	1.5e-06	6.5e-05	2.1e-06	2.5e-06
12	Brain	mRNA stability	Lima1	0.04	0.04	5.1e-03	0.01	0.02	0.02	0.02	1.4e-02	7.6e-03	6.5e-03	5.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	6.8	11.4	12.3	-3.4	-3.5	-3.5	-3.4	-3.5	3.4	-3.4	-3.3	3.4	3.4	3.4	2.8
Area under the delay curve	1.3	1.3	1.6	-1.3	-1.1	-1.1	-1.2	-1.1	1.2	-1.1	-1.3	1.0	1.2	1.1	1.1
BMI with tail	4.3	13.8	15.3	-3.7	-3.8	-3.8	-3.7	-3.8	3.7	-3.7	-3.6	3.7	3.6	3.7	3.9
BMI without tail	0.2	0.5	0.6	-0.7	-0.7	-0.7	-0.7	-0.7	0.7	-0.6	-0.7	0.7	0.6	0.7	0.8
Body weight	4.9	20.5	23.0	-4.5	-4.6	-4.6	-4.5	-4.6	4.4	-4.7	-4.4	4.3	4.8	4.4	4.6
Weight adjusted by age	0.3	0.3	0.8	-0.3	-0.6	-0.6	-0.3	-0.6	0.4	-0.9	-0.2	0.4	0.9	0.3	0.7
Bone surface	9.3	16.3	17.6	-4.1	-4.2	-4.2	-4.1	-4.2	4.1	-4.0	-4.0	4.1	4.0	4.1	3.5
Bone volume	8.6	14.7	15.4	-3.9	-3.9	-3.9	-3.9	-3.9	3.9	-3.8	-3.8	3.9	3.8	3.9	3.4
Breakpoint value in progressive ratio session	0.0	0.1	0.2	-0.1	-0.2	-0.2	-0.1	-0.2	0.1	-0.5	-0.1	0.1	0.4	0.3	0.2
Number of licking bursts	1.1	1.3	2.2	1.0	1.1	1.1	1.0	1.1	-1.0	1.5	1.0	-1.2	-1.5	-1.2	-0.8
Context. condit. distance diff. score	0.2	0.3	0.4	-0.6	-0.5	-0.5	-0.6	-0.5	0.6	-0.4	-0.6	0.4	0.5	0.4	-0.2
Locomotion velocity, session 1	4.3	4.6	5.3	2.3	2.1	2.1	2.3	2.1	-2.3	2.1	2.2	-2.1	-1.9	-2.1	-2.3
Locomotion distance, session 1	2.8	3.6	3.9	1.9	2.0	2.0	1.9	2.0	-1.9	1.9	1.9	-1.9	-1.8	-1.9	-1.8
Locomotion velocity, session 2	0.3	0.4	0.7	0.6	0.6	0.6	0.6	0.6	-0.6	0.5	0.6	-0.6	-0.6	-0.6	-0.8
Locomotion distance, session 2	3.1	4.3	5.5	2.1	2.1	2.1	2.1	2.1	-2.1	2.0	2.0	-2.1	-2.0	-2.0	-2.3
Locomotion velocity, session 3	4.5	5.3	6.0	2.4	2.4	2.4	2.4	2.4	-2.3	2.4	2.3	-2.3	-2.4	-2.2	-1.6
Locomotion distance, session 3	2.8	3.1	3.5	1.8	1.9	1.9	1.8	1.9	-1.8	1.7	1.7	-1.8	-1.6	-1.8	-1.6
Stereotopy head waving bouts, day 3	0.0	0.0	0.2	0.0	-0.1	-0.1	0.0	-0.1	-0.0	-0.2	0.0	0.1	0.2	0.2	0.4
Stereotopy head waving duration, day 3	0.0	0.1	0.1	0.3	0.2	0.2	0.3	0.2	-0.3	0.1	0.3	-0.2	-0.1	-0.1	0.3
Locomotion velocity, session 7	3.0	3.3	3.7	1.9	1.8	1.8	1.9	1.8	-1.9	1.6	1.9	-1.8	-1.4	-1.8	-1.9
Locomotion distance, session 7	4.0	5.1	5.5	2.3	2.3	2.3	2.3	2.3	-2.3	2.2	2.3	-2.3	-1.9	-2.3	-2.2
Stereotopy head waving bouts, day 7	0.5	0.5	0.8	-0.7	-0.8	-0.8	-0.7	-0.8	0.7	-0.7	-0.7	0.9	0.7	0.9	0.5
Stereotopy head waving duration, day 7	1.0	1.3	1.6	-1.1	-1.2	-1.2	-1.1	-1.1	1.1	-1.1	-1.1	1.2	1.0	1.2	1.1
Locomotion velocity, session 8	0.6	0.7	1.3	0.9	0.7	0.7	0.9	0.7	-0.9	0.7	1.0	-0.7	-0.8	-0.7	-1.1
Locomotion distance, session 8	1.2	1.8	3.8	1.2	1.3	1.3	1.2	1.3	-1.2	1.4	1.2	-1.3	-1.3	-1.3	-2.0
Degree of sensitization distance	0.0	0.0	0.0	0.0	-0.1	-0.1	0.0	-0.0	-0.0	-0.0	0.0	-0.0	0.1	-0.0	-0.1
Degree of sensitization stereotypy	0.6	0.7	0.9	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	-0.8	-0.8	1.0	0.7	0.9	0.6
Conditioned locomotion	0.0	0.0	0.1	0.1	0.1	0.1	0.1	0.1	-0.1	0.2	0.1	-0.1	-0.3	-0.1	0.3
Cocaine response after cond. corrected	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	-0.0	-0.2	0.0	0.0	0.3	-0.0	0.4
Cocaine response after cond. not corrected	0.2	0.2	0.2	0.5	0.5	0.5	0.5	0.5	-0.5	0.4	0.5	-0.5	-0.3	-0.5	0.1
Cocaine response before conditioning	2.0	2.4	3.3	1.5	1.6	1.6	1.5	1.6	-1.5	1.8	1.5	-1.5	-1.8	-1.5	-1.4
Saline control response	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	-0.0	0.2	0.1	-0.1	-0.4	-0.1	-0.5
Bone: connectivity density	3.5	5.5	6.1	-2.3	-2.5	-2.5	-2.3	-2.4	2.3	-2.4	-2.3	2.4	2.4	2.4	2.0
Bone: cortical apparent density	0.2	0.3	0.5	0.7	0.6	0.6	0.7	0.6	-0.7	0.4	0.7	-0.5	-0.3	-0.5	0.1
Bone: cortical area	5.6	8.5	9.2	-2.9	-3.0	-3.0	-2.9	-3.0	2.9	-2.9	-2.9	2.9	2.9	2.8	2.7
Bone: cortical porosity	0.1	0.1	0.1	-0.3	-0.2	-0.2	-0.4	-0.2	0.4	-0.1	-0.3	0.2	-0.0	0.2	0.3
Bone: cortical porosity	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	0.1	0.1	0.2	-0.0	-0.1	-0.2	-0.1	0.0
Bone: cortical thickness	1.5	2.4	2.8	-1.5	-1.6	-1.6	-1.5	-1.6	1.5	-1.5	-1.5	1.5	1.5	1.5	1.7
Bone: cortical thickness	0.3	0.3	0.5	0.6	0.5	0.5	0.6	0.5	-0.6	0.6	0.6	-0.6	-0.6	-0.7	-0.5
Bone: cortical tissue density	0.3	0.4	0.7	0.8	0.7	0.7	0.8	0.7	-0.8	0.5	0.8	-0.6	-0.4	-0.6	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.2	0.3	0.3	0.2	0.3	-0.2	0.4	0.2	-0.3	-0.2	-0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	-0.5	-0.4	-0.4	-0.5	-0.4	0.5	-0.3	-0.5	0.3	0.4	0.2	0.3
Condit. Reinf. active responses	0.8	0.9	1.0	1.0	0.9	0.9	1.0	0.9	-1.0	1.0	1.0	-1.0	-0.9	-1.0	-1.0
Condit. Reinf. inactive responses	2.9	3.5	3.9	2.0	1.9	1.9	2.0	1.9	-2.0	1.7	2.0	-1.8	-1.8	-1.7	-1.8
Incentive salience index mean	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.1	0.1	0.0	-0.1	-0.0	0.1	-0.1	-0.1
Condit. Reinf. lever presses	0.5	0.6	0.7	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	-0.9	-0.8	0.8	0.8	0.7	0.5
Condit. Reinf. active minus inactive responses	0.9	1.1	1.3	-1.1	-1.1	-1.1	-1.1	-1.1	1.1	-0.8	-1.1	1.1	0.5	1.2	1.1
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.1	-0.9	-0.9	-0.9	-0.9	-0.9	0.9	-0.7	-0.9	1.0	0.3	1.1	0.7
Condit. Reinf. active responses	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	-0.3	0.4	-0.2	-0.3	0.4	-0.0	0.4	0.5
Condit. Reinf. inactive responses	0.8	0.9	1.1	1.0	1.0	1.0	1.0	1.0	-1.0	0.9	1.0	-1.0	-0.8	-1.0	-0.6
Condit. Reinf. lever presses	0.0	0.0	0.1	0.1	-0.0	-0.0	0.1	-0.0	-0.1	-0.0	0.1	0.0	-0.3	0.0	0.1
Condit. Reinf. lever reinforcers received	0.0	0.0	0.3	0.1	0.1	0.1	0.1	0.1	-0.1	0.3	0.2	-0.1	-0.5	-0.1	0.1
Conditioned reinforcement - actives	1.0	1.0	1.3	1.0	1.1	1.1	1.0	1.1	-1.0	0.9	1.0	-1.0	-0.9	-0.8	-1.1
Conditioned reinforcement - inactives	2.0	2.2	2.8	1.6	1.5	1.5	1.6	1.5	-1.5	1.5	1.7	-1.4	-1.5	-1.2	-1.4
Conditioned locomotion	0.1	0.2	0.2	0.4	0.4	0.4	0.4	0.4	-0.4	0.5	0.4	-0.4	-0.5	-0.2	-0.4
Patch foraging indifference point 0 sec	6.2	10.0	10.9	3.2	3.1	3.1	3.1	3.1	-3.1	3.3	3.2	-3.3	-3.0	-3.3	-3.2
Patch foraging indifference point AUC	0.2	0.3	0.6	0.6	0.5	0.4	0.6	0.4	-0.6	0.4	0.6	-0.3	-0.8	-0.4	-0.3
Delay disc. indifference point, 0s delay	2.1	2.3	2.6	-1.5	-1.5	-1.5	-1.5	-1.5	1.5	-1.4	-1.5	1.6	1.4	1.6	1.5
Delay disc. indifference point, 16s delay	1.0	1.0	1.3	-1.0	-1.0	-1.0	-1.0	-1.0	1.0	-1.1	-1.1	0.8	1.1	1.1	1.0
Delay disc. indifference point, 2s delay	2.0	2.2	2.7	-1.6	-1.5	-1.5	-1.6	-1.5	1.6	-1.5	-1.6	1.5	1.6	1.2	1.1
Delay disc. indifference point, 24s delay	0.7	0.7	1.4	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	-0.8	-0.8	0.7	0.8	0.6	1.2
Delay disc. indifference point, 4s delay	1.2	1.2	1.8	-1.1	-1.1	-1.1	-1.1	-1.1	1.1	-1.1	-1.0	1.2	1.1	1.3	0.9
Delay disc. indifference point, 8s delay	1.6	1.7	2.1	-1.4	-1.3	-1.3	-1.4	-1.3	1.3	-1.3	-1.4	1.0	1.4	1.2	1.2
Indifference point function ln k	5.1	7.1	7.7	-2.8	-2.6	-2.6	-2.8	-2.6	2.8	-2.6	-2.8	2.5	2.7	2.5	2.6
Indifference point function log k	5.1	7.1	7.7	-2.8	-2.6	-2.6	-2.8	-2.6	2.8	-2.6	-2.8	2.5	2.7	2.5	2.6
Patch foraging total patch changes 0 sec	5.8	9.3	10.2	3.0	3.0	3.0	3.0	3.0	-3.0	3.2	3.1	-3.2	-3.0	-3.2	-3.2
Patch foraging total patch changes 12 sec	6.2	8.0	8.7	2.9	2.8	2.8	2.9	2.8	-2.9	2.8	2.9	-2.9	-2.6	-2.8	-3.0
Patch foraging total patch changes 18 sec	7.8	10.0	10.7	3.3	3.1	3.1	3.2	3.1	-3.2	3.1	3.3	-3.0	-3.3	-3.0	-3.2
Patch foraging total patch changes 24 sec	4.6	5.6	6.1	2.4	2.3	2.3	2.4	2.3	-2.4	2.5	2.4	-2.4	-2.4	-2.3	-2.3
Patch foraging total patch changes 6 sec	7.1	10.5	11.6	3.4	3.2	3.2	3.4	3.2	-3.4	3.3	3.4	-3.2	-3.1	-3.2	-2.9
Patch foraging time to switch 0 sec	2.4	3.6	4.3	2.1	2.0	2.0	2.1	2.0	-2.0	1.8	2.0	-1.9	-1.7	-1.7	-1.5
Patch foraging water rate 0 sec	3.2	5.2	5.8	-2.4	-2.3	-2.3	-2.4	-2.3	2.4	-2.1	-2.4	2.3	2.1	2.1	2.0
Patch foraging water rate 12 sec	2.7	4.1	4.7	-2.2	-2.1	-2.1	-2.2	-2.1	2.1	-1.8	-2.2	2.0	1.8	1.8	2.0
Patch foraging water rate 18 sec	0.5	0.7	1.0	-1.0	-0.7	-0.7	-1.0	-0.7	1.0	-0.6	-1.0	0.6	0.9	0.6	0.6
Patch foraging water rate 24 sec	4.7	6.6	7.2	-2.7	-2.5	-2.5	-2.7	-2.5	2.7	-2.5	-2.7	2.7	2.3	2.5	2.4
Patch foraging water rate 6 sec	5.6	8.2	9.0	-3.0	-2.9	-2.9	-3.0	-2.9	3.0	-2.9	-3.0	2.9	2.7	2.7	2.5
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.0	-1.0	-0.9	-0.9	-1.0	-0.9	1.0	-0.6	-0.9	0.9	0.4	0.8	0.7
Distance traveled before self-admin	2.5	2.7	3.1	1.7	1.6	1.6	1.7	1.7	-1.7	1.6	1.8	-1.6	-1.2	-1.6	-1.7
Distance traveled after self-admin	0.5	0.6	0.7	0.8	0.8	0.8	0.8	0.8	-0.8	0.8	0.8	-0.7	-0.5	-0.8	-0.7
Extensor digitorum longus weight	4.6	18.1	20.0	-4.2	-4.3	-4.3	-4.2	-4.3	4.2	-4.5	-4.1	4.3	4.2	4.4	4.1
Bone: elastic displacement	6.8	7.7	8.6	2.9	2.8	2.8	2.9	2.8	-2.9	2.8	2.9	-2.7	-2.7	-2.8	-2.2
Bone: elastic work	0.0	0.0	0.1	0.2	0.1	0.1	0.2	0.1	-0.2	-0.0	0.2	-0.0	0.2	-0.1	0.4
Bone: endosteal estimation	7.0	15.2	16.6	-4.1	-4.1	-4.0	-4.1	-4.0	4.1	-3.9	-4.0	3.9	3.8	3.8	2.8
Bone: endosteal perimeter	6.5	13.5	14.7	-3.8	-3.8	-3.8	-3.8	-3.8	3.8	-3.6	-3.8	3.7	3.4	3.6	3.0
Epididymis fat weight	0.0	0.0	0.0	-0.0	-0.2	-0.2	-0.0	-0.2	0.0	-0.1	-0.0	0.2	0.1	0.2	0.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.4	-0.3	-0.3	-0.4	-0.3	0.4	-0.2	-0.4	0.2	0.3	0.2	0.2
Delta time in open arm before/after self-admin	3.7	3.6	4.8	1.9	1.9	1.9	1.9	1.9	-1.9	2.1	1.9	-1.7	-2.2	-1.8	-1.8
Diff in mean of infusions in LGA sessions	1.4	1.5	2.1	-1.2	-1.3	-1.3	-1.2	-1.3	1.2	-1.4	-1.2	1.0	1.4	1.1	1.0
Delay discount exponential model param	1.2	1.3	1.6	1.2	1.1	1.1	1.2	1.1	-1.2	1.1	1.3	-1.0	-1.2	-1.1	-1.1
Extinction: sum of active levers before priming	0.8	0.8	0.9	-0.9	-0.9	-0.9	-0.9	-0.9	0.9	-0.8	-0.8	0.8	1.0	0.9	0.8
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.1	-0.2	-0.2	-0.1	-0.2	0.1	-0.5	-0.1	0.2	0.3	0.3	0.2
Bone: final force	10.5	16.9	17.7	-4.2	-4.2	-4.2	-4.2	-4.2	4.2	-4.1	-4.1	4.1	4.1	4.0	3.8
Bone: final moment	12.0	19.4	20.2	-4.5	-4.5	-4.5	-4.5	-4.5	4.5	-4.4	-4.4	4.4	4.3	4.3	4.1
Food consumed during 24 hour testing period	1.7	2.0	2.5	-1.6	-1.5	-1.5	-1.6	-1.5	1.6	-1.3	-1.6	1.3	1.3	1.2	1.0
Glucose	0.3	0.5	1.0	0.6	0.6	0.6	0.6	0.6	-0.6	1.0	0.5	-0.7	-0.9	-0.6	-0.7
Heart weight	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	-0.3	0.3	-0.3	-0.3	0.3	0.3	0.5	0.4
Delay discount hyperbolic model param	1.3	1.4	1.7	1.3	1.2	1.1	1.3	1.1	-1.3	1.1	1.3	-1.1	-1.3	-1.1	-1.1
Intermittent access intake day 1-15 change	0.1	0.1	0.2	0.3	0.5	0.5	0.3	0.5	-0.3	0.3	0.2	-0.2	-0.4	-0.1	0.0
Intermittent access intake escalation	0.0	0.0	0.1	-0.1	0.2	0.2	-0.0	0.2	0.0	-0.1	-0.1	0.1	-0.0	0.2	0.3
Intermittent access intake escalation 2	0.1	0.1	0.1	0.2	0.4	0.3	0.2	0.3	-0.2	0.2	0.2	-0.1	-0.4	-0.2	0.1
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.4	0.4	0.6	0.6	0.5	0.6	-0.5	0.6	0.4	-0.5	-0.5	-0.5	-0.4
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	0.1	0.3	0.3	0.1	0.3	-0.1	0.2	0.1	-0.2	-0.2	-0.2	-0.3
Intermitt. access escalation Index	0.8	0.7	0.9	0.7	0.8	0.8	0.8	0.8	-0.8	1.0	0.7	-0.8	-0.8	-0.9	-0.8
Intermittent access day 1 total infusions	1.3	1.5	2.0	1.2	1.2	1.2	1.2	1.2	-1.1	1.2	1.3	-1.2	-1.1	-1.1	-1.4
Intermittent access day 15 total infusions	1.5	1.7	2.1	1.3	1.5	1.5	1.3	1.4	-1.3	1.3	1.2	-1.3	-1.2	-1.1	-1.3
Intermittent access terminal intake (last 3 days)	1.5	1.6	2.0	1.2	1.4	1.4	1.2	1.4	-1.2	1.3	1.2	-1.2	-1.2	-1.1	-1.4
Intermittent access total infusions	1.5	1.7	2.0	1.3	1.4	1.4	1.3	1.4	-1.2	1.3	1.3	-1.3	-1.3	-1.0	-1.4
Intermittent access day 1 locomotion	1.5	1.6	2.0	1.3	1.3	1.3	1.2	1.3	-1.2	1.2	1.3	-1.4	-1.1	-1.1	-1.4
Intermittent access day 15 total locomotion	1.0	1.1	1.4	1.0	1.1	1.1	1.0	1.1	-1.0	1.2	1.0	-1.1	-1.1	-0.9	-0.9
Intermittent access total locomotion	3.7	4.2	4.8	2.0	2.1	2.1	2.0	2.1	-2.0	2.2	2.0	-2.1	-2.0	-1.9	-2.0
Intermittent access standard deviation	0.0	0.0	0.1	0.0	0.0	0.0	-0.0	0.0	0.0	-0.2	0.1	0.0	0.1	0.2	-0.1
Left kidney weight	1.0	2.9	4.3	-1.6	-1.6	-1.7	-1.6	-1.7	1.6	-1.8	-1.5	1.6	2.1	1.8	1.7
Right kidney weight	2.2	6.2	8.6	-2.4	-2.5	-2.5	-2.4	-2.5	2.4	-2.5	-2.4	2.4	2.9	2.4	2.4
Cocaine induced anxiety	0.9	1.0	1.5	-1.1	-1.0	-1.0	-1.0	-1.0	1.0	-1.2	-1.1	0.9	1.2	1.1	0.3
Post-drug Anxiety	5.0	5.6	6.1	-2.5	-2.4	-2.4	-2.4	-2.4	2.4	-2.4	-2.5	2.3	2.5	2.4	1.9
Baseline Anxiety	0.7	0.8	1.9	-0.7	-0.9	-0.9	-0.8	-0.9	0.8	-0.8	-0.6	0.9	0.8	0.6	1.4
Tail length	0.0	0.0	0.1	0.0	0.2	0.2	0.1	0.2	-0.1	0.2	-0.0	-0.2	0.1	-0.3	-0.2
Length with tail	1.7	6.1	8.0	-2.5	-2.5	-2.5	-2.5	-2.5	2.5	-2.5	-2.5	2.3	2.8	2.2	2.4
Length without tail	4.7	10.2	11.4	-3.1	-3.3	-3.3	-3.1	-3.3	3.1	-3.3	-3.1	3.1	3.4	3.1	3.2
Times rat made contact with spout	0.0	0.0	0.0	0.1	0.1	0.1	0.1	0.1	-0.1	0.1	0.1	-0.1	-0.1	-0.1	-0.2
Lifetime Intake	2.2	2.5	2.9	1.6	1.7	1.7	1.6	1.7	-1.6	1.5	1.6	-1.6	-1.5	-1.4	-1.6
Liver weight, left	1.6	2.6	2.9	-1.7	-1.7	-1.6	-1.7	-1.6	1.7	-1.4	-1.7	1.6	1.4	1.5	1.6
Liver weight, right	1.5	2.5	2.8	-1.6	-1.6	-1.6	-1.6	-1.6	1.6	-1.6	-1.6	1.5	1.7	1.4	1.5
Locomotor activity	1.1	1.7	2.3	1.4	1.3	1.3	1.4	1.3	-1.3	1.3	1.4	-1.5	-0.7	-1.4	-1.2
Locomotor testing distance	3.1	5.2	6.2	2.3	2.3	2.3	2.3	2.3	-2.3	2.4	2.3	-2.5	-1.8	-2.3	-2.0
Locomotor testing rearing	2.2	3.4	3.9	1.8	1.8	1.8	1.8	1.8	-1.8	1.8	1.8	-2.0	-1.6	-1.9	-1.8
Locomotion in novel chamber	2.7	3.4	4.0	-1.9	-1.8	-1.8	-1.9	-1.8	1.9	-1.9	-1.8	1.9	1.4	2.0	1.9
Locomotion in novel chamber post-restriction	0.4	0.5	0.6	-0.7	-0.7	-0.7	-0.7	-0.7	0.7	-0.8	-0.6	0.8	0.5	0.4	0.8
Fecal boli incidents, locomotor time 1	1.0	1.1	1.9	0.9	1.1	1.1	0.9	1.1	-0.9	1.4	0.9	-1.1	-1.2	-0.8	-0.8
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.4	-0.6	-0.6	-0.4	-0.6	0.4	-0.7	-0.5	0.5	0.7	0.4	0.7
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.4	0.6	0.5	0.5	0.6	0.5	-0.6	0.5	0.6	-0.6	-0.5	-0.5	-0.6
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	-0.1	0.1	0.1	-0.1	0.0	0.1	0.1	0.3
Total resting periods, locomotor time 1	0.3	0.4	0.6	0.6	0.6	0.6	0.6	0.6	-0.6	0.8	0.6	-0.7	-0.6	-0.7	-0.3
Rest time, locomotor task time 1	0.7	0.7	1.0	0.8	0.9	0.9	0.8	0.9	-0.8	1.0	0.8	-1.0	-0.8	-0.8	-0.9
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.1	0.1	0.1	0.1	0.1	-0.1	-0.0	0.1	0.0	-0.1	0.1	0.0
Vertical activity count, locomotor time 1	1.0	1.0	1.4	-1.0	-1.0	-1.0	-1.0	-1.0	1.0	-0.9	-1.0	1.1	1.0	1.2	0.8
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.9	0.6	0.6	0.6	0.6	0.6	-0.6	0.6	0.6	-0.5	-0.5	-0.1	-1.0
Bouts of movement, locomotor time 2	3.2	3.5	3.7	-1.9	-1.9	-1.9	-1.9	-1.9	1.9	-1.7	-1.9	1.9	1.8	1.7	1.9
Total resting periods, locomotor time 2	3.7	4.0	4.6	-2.0	-2.0	-2.0	-2.0	-2.0	2.0	-1.9	-2.0	2.1	1.9	1.8	2.1
Rest time, locomotor task time 2	0.1	0.2	0.4	0.4	0.3	0.3	0.4	0.3	-0.4	0.5	0.4	-0.3	-0.4	-0.6	0.2
Distance moved, locomotor task time 2	0.1	0.1	0.7	0.3	0.3	0.3	0.3	0.3	-0.3	0.2	0.3	-0.2	-0.1	0.0	-0.9
Vertical activity count, locomotor time 2	0.1	0.1	0.4	-0.4	-0.3	-0.3	-0.3	-0.3	0.3	-0.3	-0.4	0.5	0.4	0.7	-0.1
Light reinforcement 1	0.8	1.4	2.1	1.1	1.2	1.2	1.1	1.2	-1.1	1.5	1.0	-1.1	-1.4	-1.1	-1.3
Light reinforcement 2	0.0	0.1	0.1	-0.3	-0.1	-0.1	-0.3	-0.1	0.2	-0.1	-0.3	0.3	0.3	0.2	-0.3
Bone: marrow area	6.5	14.2	15.5	-3.9	-3.9	-3.9	-3.9	-3.9	3.9	-3.7	-3.9	3.8	3.7	3.7	2.7
Bone: maximum diameter	1.5	2.8	3.1	-1.7	-1.8	-1.8	-1.7	-1.7	1.7	-1.6	-1.7	1.6	1.7	1.6	1.4
Bone: maximum force	13.7	23.6	24.8	-4.9	-5.0	-5.0	-4.9	-5.0	4.9	-4.9	-4.8	4.8	4.9	4.7	4.4
Bone: maximum moment	15.5	26.6	27.8	-5.2	-5.3	-5.3	-5.2	-5.3	5.2	-5.2	-5.2	5.1	5.2	5.0	4.7
Mean time between licks in bursts	0.0	0.0	0.1	0.2	0.2	0.2	0.2	0.2	-0.2	0.0	0.2	-0.0	0.1	-0.1	-0.3
Mean num. licks in bursts	0.4	0.5	1.1	-0.6	-0.7	-0.7	-0.6	-0.7	0.6	-1.1	-0.6	0.8	1.0	0.8	0.4
Cd content in liver	0.5	0.5	0.7	0.7	0.7	0.7	0.7	0.7	-0.7	0.8	0.7	-0.7	-0.9	-0.7	-0.5
Co content in liver	0.4	0.5	0.6	0.8	0.7	0.7	0.8	0.7	-0.8	0.7	0.7	-0.7	-0.5	-0.7	-0.3
Cu content in liver	0.2	0.2	0.6	-0.5	-0.5	-0.5	-0.5	-0.5	0.5	-0.4	-0.5	0.3	0.3	0.2	0.8
Fe content in liver	1.0	1.1	1.4	1.2	1.1	1.1	1.2	1.1	-1.2	1.0	1.2	-1.0	-0.9	-1.1	-0.8
K content in liver	0.1	0.1	0.2	0.3	0.2	0.3	0.3	0.3	-0.3	0.2	0.3	-0.3	-0.2	-0.4	-0.1
Mg content in liver	0.2	0.2	0.4	0.5	0.5	0.5	0.4	0.5	-0.4	0.4	0.5	-0.5	-0.5	-0.6	-0.1
Mn content in liver	0.1	0.2	0.3	-0.4	-0.4	-0.4	-0.4	-0.4	0.4	-0.4	-0.5	0.3	0.4	0.1	0.5
Na content in liver	0.3	0.3	0.4	0.6	0.5	0.5	0.6	0.5	-0.6	0.5	0.6	-0.5	-0.5	-0.5	-0.3
Rb content in liver	2.2	2.8	3.3	1.7	1.6	1.6	1.7	1.6	-1.7	1.7	1.6	-1.8	-1.6	-1.8	-1.5
Se content in liver	2.1	2.6	2.9	1.7	1.6	1.6	1.7	1.6	-1.7	1.6	1.7	-1.6	-1.7	-1.6	-1.2
Sr content in liver	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.1	0.1	-0.0	-0.1	0.1	-0.1	0.2	0.0
Zn content in liver	2.7	3.0	3.4	1.7	1.7	1.7	1.7	1.7	-1.7	1.8	1.7	-1.8	-1.7	-1.8	-1.9
Bone: minimum diameter	8.0	15.0	16.0	-4.0	-4.0	-4.0	-4.0	-4.0	4.0	-3.9	-3.9	3.9	3.8	3.8	3.4
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.1	-0.1	0.1	-0.1	-0.1	0.2	0.0	0.2	-0.1
Time in novel zone, hab. session 1	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.2	-0.1	0.2	0.0	-0.2	0.0	0.1	0.1	0.3
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.3	0.3	0.3	0.3	0.3	-0.3	0.4	0.3	-0.2	-0.4	-0.2	-0.3
Total locomotion distance, hab. session 1	0.3	0.4	0.5	0.6	0.6	0.7	0.6	0.7	-0.6	0.7	0.6	-0.7	-0.5	-0.7	-0.1
Locomotion velocity, hab. session 1	0.2	0.2	0.3	0.5	0.5	0.5	0.5	0.5	-0.5	0.5	0.4	-0.6	-0.4	-0.6	-0.1
Time in familiar zone, hab. session 2	1.5	1.6	1.8	-1.3	-1.3	-1.3	-1.3	-1.3	1.3	-1.3	-1.3	1.3	1.2	1.3	0.8
Time in novel zone, hab. session 2	1.7	1.7	2.1	1.3	1.3	1.3	1.3	1.3	-1.3	1.5	1.3	-1.4	-1.2	-1.4	-0.9
Total zone transitions, hab. session 2	0.2	0.3	0.3	0.5	0.5	0.5	0.5	0.5	-0.5	0.6	0.5	-0.6	-0.6	-0.6	-0.4
Total locomotion distance, hab. session 2	0.4	0.5	0.7	0.6	0.7	0.7	0.7	0.7	-0.7	0.8	0.6	-0.8	-0.7	-0.8	-0.4
Locomotion velocity, hab. session 2	0.2	0.3	0.4	0.5	0.5	0.5	0.5	0.5	-0.5	0.6	0.4	-0.6	-0.5	-0.7	-0.2
Novel to familiar place preference ratio	1.5	1.5	2.5	-1.3	-1.3	-1.3	-1.3	-1.3	1.3	-1.0	-1.3	1.1	1.0	1.1	1.6
Novelty place preference	0.9	0.9	1.8	-1.0	-1.0	-1.0	-1.0	-1.0	1.0	-0.7	-1.0	0.8	0.7	0.8	1.3
Time in novel zone, NPP test	0.6	0.6	1.5	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	-0.5	-0.8	0.7	0.6	0.7	1.2
Total zone transitions, NPP test	2.7	3.8	4.1	2.0	2.0	2.0	2.0	2.0	-2.0	2.0	1.9	-2.0	-1.8	-2.0	-1.9
Total locomotion distance, NPP test	3.5	4.8	5.3	2.2	2.2	2.2	2.2	2.2	-2.2	2.2	2.1	-2.3	-2.1	-2.3	-1.9
Locomotion velocity, NPP test	2.3	3.2	3.6	1.8	1.8	1.8	1.8	1.8	-1.8	1.8	1.8	-1.9	-1.8	-1.9	-1.5
Intraocular pressure	5.0	7.0	7.6	2.6	2.7	2.7	2.6	2.7	-2.6	2.7	2.6	-2.5	-2.7	-2.6	-2.8
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.6	-0.5	-0.5	-0.6	-0.5	0.6	-0.3	-0.6	0.5	0.2	0.4	0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.5	-0.3	-0.3	-0.4	-0.3	0.4	-0.2	-0.5	0.3	0.1	0.3	0.3
Parametrial fat weight	1.2	2.4	3.0	1.6	1.6	1.6	1.5	1.6	-1.5	1.6	1.6	-1.5	-1.7	-1.5	-1.5
Pavlov. Cond. lever latency	0.2	0.2	0.6	0.4	0.4	0.4	0.4	0.4	-0.4	0.5	0.4	-0.4	-0.3	-0.4	-0.8
Pavlov. Cond. magazine entry latency	1.0	1.3	1.6	-1.2	-1.1	-1.1	-1.2	-1.1	1.3	-1.1	-1.2	1.1	1.1	1.1	0.9
Pavlov. Cond. change in total contacts	1.3	1.4	1.5	-1.2	-1.1	-1.2	-1.2	-1.2	1.2	-1.2	-1.1	1.2	1.1	1.2	1.2
Pavlov. Cond. index score	0.8	1.0	1.2	-1.0	-1.0	-1.0	-1.0	-1.0	1.0	-1.0	-1.0	0.9	0.9	0.9	1.1
Pavlov. Cond. latency score	0.6	0.7	1.1	-0.9	-0.8	-0.8	-0.9	-0.9	0.9	-0.9	-0.8	0.8	0.7	0.8	1.0
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.3	-0.2	-0.2	-0.3	-0.2	0.3	-0.4	-0.2	0.3	0.2	0.2	0.6
Pavlov. Cond. magazine entry number	0.4	0.4	0.6	0.7	0.7	0.7	0.8	0.7	-0.8	0.7	0.7	-0.6	-0.7	-0.6	-0.3
Pavlov. Cond. intertrial magazine entries	4.9	5.9	6.6	2.6	2.4	2.4	2.6	2.4	-2.6	2.3	2.5	-2.5	-2.2	-2.5	-2.1
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.6	-1.2	-1.2	-1.2	-1.2	-1.2	1.2	-1.2	-1.1	1.1	1.1	1.1	1.3
Pavlov. Cond. response bias	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.6	-0.6	0.6	-0.6	-0.6	0.6	0.6	0.5	0.5
Pavlov. Cond. lever latency	1.1	1.4	2.2	-1.3	-1.1	-1.1	-1.3	-1.1	1.2	-1.1	-1.3	1.1	1.5	1.1	1.3
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	0.4	0.2	0.2	0.4	0.2	-0.4	0.4	0.4	-0.2	-0.6	-0.2	-0.7
Pavlov. Cond. change in total contacts	0.3	0.5	0.7	-0.7	-0.9	-0.9	-0.7	-0.9	0.7	-0.7	-0.6	0.7	0.4	0.7	0.3
Pavlov. Cond. index score	0.5	0.7	1.4	0.9	0.6	0.6	0.9	0.6	-0.8	0.8	0.9	-0.7	-1.1	-0.7	-1.2
Pavlov. Cond. latency score	0.5	0.7	1.5	0.8	0.6	0.6	0.8	0.6	-0.8	0.8	0.8	-0.7	-1.1	-0.7	-1.2
Pavlov. Cond. lever contacts	0.9	1.3	2.2	1.2	1.0	1.0	1.2	1.0	-1.1	1.1	1.2	-1.0	-1.5	-1.0	-1.2
Pavlov. Cond. magazine entry number	0.0	0.1	0.4	-0.2	0.1	0.1	-0.2	0.1	0.2	-0.2	-0.2	-0.0	0.4	-0.0	0.6
Pavlov. Cond. intertrial magazine entries	1.8	2.3	2.8	1.5	1.7	1.7	1.5	1.6	-1.5	1.5	1.5	-1.7	-1.4	-1.6	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.7	0.5	0.3	0.3	0.5	0.3	-0.5	0.5	0.6	-0.4	-0.8	-0.4	-0.8
Pavlov. Cond. response bias	0.5	0.7	1.4	0.9	0.7	0.7	0.8	0.7	-0.8	0.9	0.9	-0.7	-1.2	-0.7	-0.9
Time in closed arm before self-admin	0.9	1.0	1.2	-0.9	-1.1	-1.1	-0.9	-1.0	0.9	-1.1	-0.9	1.1	0.9	1.0	1.0
Time in closed arm after self-admin	0.4	0.4	0.6	-0.7	-0.7	-0.7	-0.7	-0.7	0.6	-0.8	-0.7	0.6	0.7	0.6	0.6
Time in open arm before self-admin	0.2	0.2	1.0	-0.4	-0.3	-0.3	-0.4	-0.3	0.4	-0.5	-0.4	0.1	1.0	0.2	0.3
Time in open arm after self-admin	0.2	0.2	0.3	0.5	0.5	0.5	0.5	0.5	-0.5	0.4	0.5	-0.5	-0.3	-0.6	-0.5
Bone: periosteal estimation	9.0	18.5	20.1	-4.4	-4.5	-4.5	-4.4	-4.5	4.4	-4.3	-4.4	4.3	4.3	4.2	3.5
Bone: periosteal perimeter	9.0	15.0	16.0	-4.0	-4.0	-4.0	-4.0	-4.0	4.0	-3.7	-3.9	3.8	3.7	3.8	3.4
Bone: post-yield work	8.1	11.0	12.2	-3.5	-3.4	-3.4	-3.5	-3.4	3.5	-3.3	-3.5	3.3	3.3	3.2	2.2
Progressive ratio test 1 active lever presses	8.3	8.6	9.6	2.9	3.0	3.0	2.9	3.0	-2.9	3.1	2.9	-3.0	-2.8	-2.8	-2.9
Progressive ratio test 1 breakpoint	6.9	7.3	8.1	2.7	2.8	2.8	2.7	2.8	-2.7	2.9	2.6	-2.8	-2.6	-2.6	-2.7
Progressive ratio test 1 inactive lever presses	2.0	2.2	2.6	1.5	1.6	1.6	1.5	1.6	-1.5	1.4	1.4	-1.5	-1.4	-1.3	-1.3
Progressive ratio test 2 active lever presses	1.9	2.1	2.3	1.4	1.5	1.5	1.4	1.5	-1.4	1.5	1.4	-1.4	-1.4	-1.3	-1.5
Progressive ratio test 2 breakpoint	2.1	2.4	2.7	1.5	1.6	1.6	1.5	1.6	-1.5	1.6	1.5	-1.5	-1.6	-1.6	-1.5
Progressive ratio test 2 inactive lever presses	1.0	1.2	1.4	1.1	1.2	1.2	1.1	1.2	-1.1	1.1	1.1	-1.0	-1.1	-0.8	-1.1
Incentive Sensitization - Responses	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.6	-0.6	0.7	-0.5	-0.6	0.6	0.4	0.6	0.5
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	-0.6	-0.5	-0.5	-0.6	-0.5	0.6	-0.4	-0.5	0.6	0.3	0.5	0.5
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.5	0.7	0.7	0.7	0.7	0.7	-0.7	0.6	0.7	-0.6	-0.7	-0.5	-0.5
Progressive ratio	1.0	1.1	1.4	1.1	1.0	1.0	1.1	1.1	-1.1	1.1	1.1	-1.1	-1.0	-1.2	-0.9
Food seeking constrained by brief footshock	1.7	2.1	2.4	1.5	1.5	1.5	1.5	1.5	-1.5	1.3	1.4	-1.5	-1.1	-1.5	-1.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.3	-0.3	-0.3	-0.3	-0.3	0.3	-0.4	-0.4	0.4	0.4	0.3	0.2
Retroperitoneal fat weight	1.1	3.6	4.2	2.0	1.9	1.9	2.0	1.9	-1.9	1.8	2.0	-1.9	-1.7	-1.8	-2.0
Reaction time number correct	1.1	1.6	1.8	-1.3	-1.3	-1.3	-1.3	-1.3	1.3	-1.3	-1.3	1.2	1.2	1.2	0.8
Reaction time mean minus median	5.6	7.4	8.5	2.7	2.8	2.8	2.7	2.7	-2.7	2.9	2.6	-2.7	-2.9	-2.6	-2.6
Reaction time mean minus median AUC	4.1	5.3	6.2	2.3	2.3	2.3	2.3	2.3	-2.3	2.5	2.2	-2.2	-2.5	-2.2	-2.2
Reaction time num false alarms	1.4	1.9	2.2	1.3	1.4	1.4	1.3	1.4	-1.3	1.5	1.4	-1.4	-1.5	-1.2	-1.4
Reaction time num false alarms AUC	1.5	2.1	2.6	1.4	1.5	1.5	1.4	1.5	-1.4	1.6	1.5	-1.5	-1.6	-1.3	-1.3
Reaction time trials correct on left	1.1	1.6	1.8	-1.3	-1.3	-1.3	-1.3	-1.3	1.3	-1.3	-1.3	1.2	1.2	1.2	0.8
Reaction time trials on left	0.9	1.2	1.4	-1.2	-1.2	-1.1	-1.2	-1.1	1.2	-1.2	-1.2	1.1	1.1	1.0	0.7
Reaction time mean	0.6	0.8	1.1	0.9	1.0	1.0	0.9	1.0	-0.9	1.1	0.9	-0.9	-0.9	-0.8	-0.6
Reaction time mean AUC	0.3	0.4	0.6	0.7	0.7	0.7	0.7	0.7	-0.7	0.8	0.7	-0.6	-0.6	-0.6	-0.3
Median of all reaction times	0.0	0.0	0.1	0.0	0.1	0.1	0.0	0.1	-0.0	0.2	0.0	-0.0	0.0	0.0	0.4
Reaction time omissions	7.7	10.5	11.1	3.3	3.3	3.3	3.3	3.3	-3.3	3.2	3.3	-3.1	-3.1	-3.1	-3.1
Reaction time false alarm rate	1.7	2.4	3.0	1.6	1.6	1.6	1.6	1.6	-1.5	1.7	1.6	-1.6	-1.7	-1.4	-1.1
Reaction time premature initiation rate	4.5	6.0	6.6	2.6	2.5	2.5	2.5	2.5	-2.5	2.2	2.6	-2.4	-2.1	-2.5	-2.5
Reaction time premature initiations	1.9	2.7	3.7	1.7	1.7	1.7	1.7	1.7	-1.7	1.3	1.7	-1.6	-1.3	-1.7	-1.9
Std. dev. reaction times	4.8	6.7	7.7	2.6	2.6	2.6	2.6	2.6	-2.6	2.8	2.5	-2.5	-2.7	-2.5	-2.4
Reaction time trials completed	0.9	1.2	1.4	-1.2	-1.2	-1.1	-1.2	-1.1	1.2	-1.2	-1.2	1.1	1.1	1.0	0.7
Reaction time trials AUC	1.4	2.1	2.3	-1.5	-1.5	-1.5	-1.5	-1.5	1.5	-1.5	-1.5	1.4	1.4	1.3	1.0
Run reversals in cocaine runway, females	0.5	0.5	0.9	-0.7	-0.6	-0.6	-0.7	-0.6	0.7	-0.9	-0.6	0.7	0.6	0.7	0.8
Run reversals in cocaine runway, males	1.0	1.0	1.8	1.0	0.9	0.9	1.0	0.9	-0.9	1.0	1.1	-0.8	-1.4	-1.2	-0.4
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.2	0.0	0.0	-0.2	0.0	0.2	-0.1	-0.2	-0.1	0.3	-0.2	-0.3
Latency to leave start box in cocaine runway, F	1.5	1.6	2.1	1.3	1.3	1.3	1.2	1.3	-1.2	1.2	1.2	-1.3	-0.8	-1.4	-1.4
Latency to leave start box in cocaine runway, M	2.3	2.2	2.6	-1.6	-1.6	-1.6	-1.6	-1.6	1.6	-1.4	-1.5	1.5	1.3	1.4	1.3
Std. dev. time between licks in bursts	1.3	1.6	2.4	1.2	1.3	1.3	1.2	1.3	-1.2	1.3	1.2	-1.1	-1.1	-1.3	-1.6
Total sessions with >9 infusions	1.4	1.5	1.7	1.2	1.3	1.3	1.2	1.3	-1.2	1.3	1.2	-1.3	-1.2	-0.9	-1.2
Short access day 1 total inactive lever presses	1.1	1.2	1.4	1.1	1.2	1.2	1.1	1.2	-1.1	1.2	1.0	-1.2	-1.1	-1.0	-1.2
Short access day 10 total inactive lever presses	0.1	0.1	0.1	-0.3	-0.2	-0.2	-0.3	-0.2	0.3	-0.2	-0.3	0.3	0.2	0.2	0.3
Short access day 1 total infusions	0.5	0.6	0.8	0.7	0.8	0.8	0.7	0.8	-0.7	0.8	0.7	-0.9	-0.7	-0.6	-0.9
Short access day 10 total infusions	2.7	3.0	3.2	1.8	1.8	1.8	1.8	1.8	-1.7	1.7	1.8	-1.7	-1.6	-1.6	-1.6
Short access total infusions	1.7	1.9	2.0	1.4	1.4	1.4	1.4	1.4	-1.4	1.3	1.4	-1.4	-1.3	-1.2	-1.4
Short access day 1 locomotion	0.2	0.2	0.3	0.5	0.5	0.5	0.4	0.5	-0.4	0.5	0.5	-0.5	-0.5	-0.4	-0.3
Short access day 10 total locomotion	0.2	0.2	0.4	0.6	0.4	0.4	0.5	0.4	-0.5	0.4	0.7	-0.5	-0.5	-0.3	-0.5
Short access total locomotion	0.6	0.6	0.9	0.9	0.8	0.8	0.8	0.8	-0.8	0.7	1.0	-0.7	-0.8	-0.6	-0.7
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.2	-0.2	-0.2	-0.2	-0.2	0.2	-0.4	-0.2	0.2	0.2	0.4	0.4
Compulsive drug intake	2.0	2.0	2.4	-1.5	-1.4	-1.4	-1.4	-1.4	1.4	-1.5	-1.5	1.3	1.3	1.4	1.5
One hour access (shock baseline)	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0	0.0	0.0	-0.1	0.0	0.1	0.0	0.2	-0.0
Social response proportion	0.1	0.1	0.2	0.3	0.3	0.3	0.3	0.3	-0.3	0.1	0.3	-0.3	-0.1	-0.4	-0.1
Social responses	5.0	6.4	7.2	2.5	2.6	2.6	2.5	2.5	-2.5	2.7	2.5	-2.5	-2.7	-2.7	-2.2
Social time	0.3	0.4	1.0	-0.6	-0.6	-0.6	-0.6	-0.6	0.6	-0.7	-0.6	0.5	0.8	0.6	1.0
Soleus weight	1.0	3.0	3.3	-1.8	-1.7	-1.7	-1.8	-1.7	1.8	-1.8	-1.8	1.8	1.7	1.8	1.6
Bone: stiffness	18.0	28.5	30.2	-5.5	-5.4	-5.4	-5.5	-5.4	5.5	-5.4	-5.4	5.3	5.4	5.2	4.5
Tibialis anterior weight	3.0	10.1	11.3	-3.1	-3.2	-3.2	-3.1	-3.2	3.1	-3.4	-3.0	3.2	3.0	3.3	3.2
Time to tail flick, vehicle, before self-admin	0.7	0.7	0.8	0.9	0.8	0.8	0.9	0.8	-0.9	0.7	0.9	-0.8	-0.7	-0.7	-0.8
Time to tail flick, vehicle, after self-admin	0.6	0.6	1.1	-0.7	-0.8	-0.8	-0.7	-0.8	0.7	-1.0	-0.7	0.7	0.9	0.7	0.7
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.4	0.4	0.4	0.4	0.4	-0.4	0.1	0.4	-0.3	-0.1	-0.3	-0.3
Time to tail flick, test, after self-admin	0.8	0.9	1.2	-0.9	-0.9	-0.9	-0.9	-0.9	0.8	-1.0	-0.9	0.9	1.1	1.0	0.9
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	0.9	-0.8	-0.9	-0.9	-0.8	-0.9	0.8	-1.0	-0.8	0.8	0.8	0.7	0.8
Delta time to tail flick, test, before/after SA	0.8	0.7	0.8	-0.9	-0.9	-0.9	-0.9	-0.9	0.9	-0.7	-0.8	0.9	0.6	0.8	0.8
Tibia length	4.1	11.6	12.9	-3.5	-3.6	-3.6	-3.5	-3.6	3.5	-3.4	-3.4	3.4	3.5	3.3	2.7
Ambulatory time before self-admin	4.3	4.4	4.7	2.2	2.1	2.1	2.2	2.1	-2.2	2.1	2.2	-2.0	-1.9	-2.0	-2.1
Ambulatory time after self-admin	1.7	1.8	2.5	1.3	1.4	1.4	1.3	1.4	-1.3	1.6	1.3	-1.2	-1.5	-1.2	-1.2
Bone: tissue strength	2.1	2.1	2.4	-1.5	-1.4	-1.4	-1.5	-1.4	1.5	-1.5	-1.5	1.4	1.5	1.4	1.3
Total heroin consumption	1.2	1.4	1.9	-1.2	-1.2	-1.2	-1.2	-1.2	1.2	-1.3	-1.3	1.0	1.4	1.1	0.8
Bone: trabecular number	3.7	5.7	6.2	-2.4	-2.5	-2.5	-2.4	-2.5	2.4	-2.4	-2.3	2.5	2.4	2.4	1.9
Bone: trabecular spacing	1.1	1.4	2.3	1.1	1.2	1.2	1.1	1.2	-1.1	1.4	1.1	-1.2	-1.5	-1.2	-0.7
Bone: trabecular thickness	0.6	0.7	1.2	-0.8	-0.7	-0.7	-0.8	-0.7	0.8	-0.9	-0.8	0.8	0.9	0.8	1.1
Bone: trabecular tissue density	0.8	1.2	2.1	-1.1	-1.0	-1.0	-1.1	-1.0	1.1	-1.0	-1.1	1.1	0.8	1.2	1.5
Water consumed over 24 hours	0.1	0.1	0.2	0.2	0.3	0.3	0.2	0.3	-0.2	0.3	0.2	-0.4	-0.3	-0.4	-0.2
Number of responses in last shaping day	0.4	0.5	0.7	-0.8	-0.6	-0.6	-0.7	-0.6	0.7	-0.7	-0.8	0.7	0.6	0.8	0.6