Hub : Genes

Lhfpl5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Lhfpl5 0.19 0.1 9.8e-09 0.14 0.15 0.13 0.13 4.1e-08 2.0e-08 2.5e-07 2.7e-07
2 IL gene expression Lhfpl5 0.4 0.13 3.3e-10 0.23 0.27 0.2 0.26 2.9e-06 3.2e-07 1.5e-05 8.0e-07
3 OFC gene expression Lhfpl5 0.37 0.13 2.4e-09 0.37 0.4 0.4 0.4 1.2e-09 1.1e-10 2.1e-10 1.9e-10
4 Brain gene expression Lhfpl5 0.27 0.1 0.0e+00 0.31 0.3 0.32 0.32 3.7e-29 3.1e-28 2.6e-30 3.2e-30
5 PL gene expression Lhfpl5 0.32 0.1 0.0e+00 0.44 0.47 0.47 0.47 3.3e-53 3.3e-57 1.4e-57 4.7e-58
6 pVTA gene expression Lhfpl5 0.18 0.09 7.6e-08 0.14 0.12 0.1 0.13 1.2e-06 8.5e-06 2.9e-05 3.4e-06
7 NAcc gene expression Lhfpl5 0.22 0.11 0.0e+00 0.29 0.28 0.29 0.28 8.2e-34 7.3e-33 1.7e-33 3.7e-33
8 RMTg gene expression Lhfpl5 0.12 0.07 9.3e-04 0.09 0.1 0.02 0.07 1.7e-03 1.6e-03 1.1e-01 7.4e-03
9 LHb gene expression Lhfpl5 0.38 0.19 8.4e-05 0.14 0.14 0.12 0.12 3.6e-04 2.9e-04 8.7e-04 7.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.50.81.31.10.81.0-1.00.9-1.1-0.80.70.7
Area under the delay curve0.20.20.4-0.2-0.3-0.50.4-0.50.40.5-0.7-0.3
BMI with tail1.65.38.5-1.7-2.3-2.02.3-2.42.02.4-2.5-2.9
BMI without tail1.22.43.9-1.6-1.4-1.61.5-1.51.31.5-1.4-2.0
Body weight4.719.627.3-3.7-3.9-4.74.7-4.84.35.2-4.7-3.6
Weight adjusted by age0.40.41.2-0.2-0.5-0.60.4-0.80.31.1-0.9-0.2
Bone surface0.00.00.20.00.2-0.0-0.10.1-0.30.10.10.4
Bone volume0.00.00.10.10.1-0.1-0.0-0.1-0.10.2-0.1-0.0
Breakpoint value in progressive ratio session0.10.10.2-0.1-0.30.3-0.30.3-0.2-0.50.10.4
Number of licking bursts0.30.40.80.10.70.5-0.50.8-0.5-0.70.90.5
Context. condit. distance diff. score0.60.81.80.31.00.6-0.70.9-0.8-0.81.11.4
Locomotion velocity, session 11.31.42.41.21.61.0-1.11.2-1.4-0.81.21.0
Locomotion distance, session 13.44.45.22.12.22.2-2.12.2-2.3-2.12.11.3
Locomotion velocity, session 20.30.30.70.00.50.3-0.40.6-0.8-0.50.70.6
Locomotion distance, session 21.01.41.61.21.31.2-1.21.2-1.2-1.11.21.1
Locomotion velocity, session 30.60.82.6-0.8-0.2-0.90.9-0.70.60.9-0.5-1.6
Locomotion distance, session 30.30.30.80.40.90.5-0.40.5-0.6-0.50.8-0.4
Stereotopy head waving bouts, day 31.51.82.6-1.5-1.1-1.61.4-1.31.61.5-1.2-0.7
Stereotopy head waving duration, day 30.00.10.2-0.10.0-0.20.1-0.00.30.3-0.10.5
Locomotion velocity, session 70.30.30.80.90.70.5-0.60.3-0.6-0.10.20.3
Locomotion distance, session 71.52.03.21.81.61.4-1.41.3-1.4-1.01.21.3
Stereotopy head waving bouts, day 70.70.71.9-0.9-0.4-0.90.9-0.70.90.7-0.5-1.4
Stereotopy head waving duration, day 71.51.93.5-1.4-1.0-1.41.4-1.31.41.3-1.1-1.9
Locomotion velocity, session 80.20.31.6-0.00.60.0-0.20.4-0.2-0.10.51.3
Locomotion distance, session 81.11.62.40.91.41.1-1.11.3-1.1-1.21.51.6
Degree of sensitization distance0.30.32.30.5-0.00.3-0.50.2-0.2-0.1-0.01.5
Degree of sensitization stereotypy0.20.21.3-0.30.1-0.30.3-0.20.20.10.0-1.1
Conditioned locomotion3.23.75.3-2.3-2.1-2.11.9-1.91.91.8-1.9-1.2
Cocaine response after cond. corrected0.60.70.9-1.0-1.0-0.80.8-0.90.80.7-0.8-1.0
Cocaine response after cond. not corrected0.60.61.1-1.0-0.8-0.90.8-0.80.90.7-0.6-0.6
Cocaine response before conditioning0.10.10.6-0.00.3-0.10.00.10.20.00.20.8
Saline control response0.81.12.1-0.8-1.5-0.80.8-1.11.00.8-1.3-1.1
Bone: connectivity density0.50.81.61.00.70.9-1.00.8-1.3-0.70.60.9
Bone: cortical apparent density0.20.20.7-0.2-0.6-0.20.3-0.40.80.2-0.4-0.6
Bone: cortical area0.10.10.40.0-0.0-0.30.2-0.30.00.4-0.3-0.7
Bone: cortical porosity0.30.30.90.90.90.4-0.40.3-0.60.00.30.2
Bone: cortical porosity0.40.41.11.11.00.5-0.50.5-0.6-0.10.40.8
Bone: cortical thickness0.30.51.21.10.60.7-0.70.4-0.8-0.50.3-1.1
Bone: cortical thickness0.20.21.3-0.0-0.5-0.00.1-0.3-0.10.1-0.5-1.1
Bone: cortical tissue density0.20.30.8-0.4-0.7-0.30.4-0.50.90.3-0.5-0.6
Condit. Reinf. active minus inactive responses1.31.52.41.51.11.3-1.31.1-1.3-0.90.81.5
Condit. Reinf. active-inactive response ratio0.10.10.20.3-0.10.4-0.30.1-0.2-0.20.00.4
Condit. Reinf. active responses0.40.41.11.00.50.7-0.70.5-0.7-0.30.20.9
Condit. Reinf. inactive responses0.20.20.70.80.30.6-0.50.3-0.4-0.30.10.3
Incentive salience index mean0.60.71.41.00.90.8-0.80.7-0.8-0.50.71.2
Condit. Reinf. lever presses0.20.20.40.50.70.3-0.40.4-0.4-0.20.40.6
Condit. Reinf. active minus inactive responses0.81.02.60.90.90.9-0.90.9-0.7-0.80.91.6
Condit. Reinf. active-inactive response ratio0.40.41.60.50.50.5-0.50.5-0.4-0.40.51.2
Condit. Reinf. active responses0.81.12.21.01.01.0-1.01.1-0.7-0.91.01.5
Condit. Reinf. inactive responses0.00.00.1-0.0-0.1-0.10.1-0.10.30.1-0.1-0.2
Condit. Reinf. lever presses4.15.57.02.32.12.5-2.42.4-2.2-2.42.32.6
Condit. Reinf. lever reinforcers received1.72.43.71.51.51.5-1.61.6-1.3-1.41.51.9
Conditioned reinforcement - actives0.20.20.70.20.2-0.40.0-0.30.00.8-0.4-0.5
Conditioned reinforcement - inactives0.10.10.30.50.60.4-0.10.20.1-0.30.50.2
Conditioned locomotion0.10.20.70.60.2-0.2-0.1-0.3-0.20.8-0.60.2
Patch foraging indifference point 0 sec0.50.81.4-0.5-0.8-0.70.9-0.91.10.6-0.8-1.2
Patch foraging indifference point AUC0.10.10.2-0.30.3-0.10.00.20.0-0.30.40.5
Delay disc. indifference point, 0s delay0.10.10.20.20.20.1-0.40.3-0.40.1-0.00.0
Delay disc. indifference point, 16s delay0.00.00.10.20.2-0.10.2-0.30.10.4-0.2-0.2
Delay disc. indifference point, 2s delay0.50.61.10.80.60.7-0.80.7-1.0-0.70.41.0
Delay disc. indifference point, 24s delay1.00.92.1-0.3-0.7-0.90.9-1.10.81.4-1.2-0.8
Delay disc. indifference point, 4s delay0.70.70.9-0.9-1.0-1.00.8-0.80.90.7-1.0-0.6
Delay disc. indifference point, 8s delay0.70.71.2-0.5-0.7-0.90.8-0.90.71.0-1.1-0.5
Indifference point function ln k0.10.20.50.40.70.3-0.50.5-0.4-0.40.50.1
Indifference point function log k0.10.20.50.40.70.3-0.50.5-0.4-0.40.50.1
Patch foraging total patch changes 0 sec0.50.71.5-0.4-0.8-0.60.9-0.91.20.6-0.8-1.2
Patch foraging total patch changes 12 sec0.10.10.4-0.2-0.0-0.00.3-0.10.4-0.30.1-0.6
Patch foraging total patch changes 18 sec1.21.52.6-1.0-1.3-1.01.3-1.21.60.8-1.1-1.6
Patch foraging total patch changes 24 sec0.20.20.60.70.20.7-0.40.3-0.1-0.80.4-0.1
Patch foraging total patch changes 6 sec0.20.30.9-0.3-0.6-0.20.6-0.50.60.0-0.5-0.9
Patch foraging time to switch 0 sec1.32.03.5-1.3-1.9-1.21.1-1.41.01.2-1.7-1.7
Patch foraging water rate 0 sec0.20.40.80.80.90.6-0.30.5-0.2-0.50.80.7
Patch foraging water rate 12 sec0.10.10.30.30.50.3-0.30.3-0.3-0.40.6-0.2
Patch foraging water rate 18 sec0.40.51.01.00.50.9-0.50.6-0.4-0.70.60.9
Patch foraging water rate 24 sec0.20.20.70.30.50.5-0.20.5-0.0-0.70.80.1
Patch foraging water rate 6 sec0.10.20.50.40.60.5-0.40.5-0.3-0.40.70.2
Seeking ratio, delayed vs. immediate footshock0.40.41.1-1.0-0.7-0.60.7-0.41.00.2-0.2-0.5
Distance traveled before self-admin2.02.23.8-2.0-1.4-1.51.8-1.31.90.9-0.9-1.1
Distance traveled after self-admin1.01.12.4-1.5-1.2-1.01.3-0.91.50.5-0.5-0.4
Extensor digitorum longus weight0.20.92.60.50.90.7-0.71.0-0.7-0.81.11.6
Bone: elastic displacement0.20.30.91.00.80.5-0.50.4-0.4-0.20.3-0.0
Bone: elastic work0.10.10.50.70.30.3-0.30.1-0.20.0-0.0-0.0
Bone: endosteal estimation2.65.67.3-2.6-2.4-2.72.5-2.52.32.6-2.4-0.6
Bone: endosteal perimeter1.73.55.4-2.3-1.9-2.12.1-1.91.91.9-1.6-0.5
Epididymis fat weight1.74.111.9-0.8-2.0-1.31.6-2.21.21.9-2.4-3.5
Delta time in closed arm before/after self-admin1.41.41.9-0.9-1.0-1.11.2-1.31.41.2-1.2-1.3
Delta time in open arm before/after self-admin1.01.01.50.90.81.0-1.21.1-1.2-1.00.80.9
Diff in mean of infusions in LGA sessions0.60.61.20.70.40.9-0.80.7-0.7-0.90.71.1
Delay discount exponential model param0.10.20.30.10.20.4-0.40.5-0.4-0.40.60.2
Extinction: sum of active levers before priming0.10.10.30.20.30.3-0.30.4-0.2-0.50.40.2
Active lever presses in extinction session 60.20.20.91.00.00.5-0.50.0-0.40.1-0.30.4
Bone: final force3.96.37.7-2.1-2.6-2.42.4-2.72.22.6-2.8-2.7
Bone: final moment2.84.65.9-1.7-2.2-2.12.0-2.31.82.3-2.4-2.3
Food consumed during 24 hour testing period0.60.71.8-1.0-1.3-0.80.8-0.90.80.6-1.00.0
Glucose0.40.72.10.51.20.3-0.50.6-0.9-0.10.81.5
Heart weight3.24.55.22.32.32.1-1.92.1-2.1-2.02.02.2
Delay discount hyperbolic model param0.00.10.20.00.10.3-0.20.3-0.2-0.20.40.0
Intermittent access intake day 1-15 change1.51.52.3-1.4-1.2-1.31.1-1.11.21.1-1.1-1.5
Intermittent access intake escalation2.32.23.1-1.8-1.5-1.61.4-1.41.51.4-1.4-1.5
Intermittent access intake escalation 20.00.00.2-0.40.1-0.30.10.00.10.10.10.3
Intermitt. access day 1 inactive lever presses0.10.20.6-0.8-0.1-0.30.30.00.5-0.20.3-0.5
Intermitt. access day 15 inactive lever presses2.02.23.0-1.7-1.3-1.61.5-1.41.61.4-1.2-1.4
Intermitt. access escalation Index0.10.10.5-0.20.10.3-0.20.4-0.2-0.70.5-0.1
Intermittent access day 1 total infusions1.21.42.71.71.51.1-1.31.0-1.6-0.40.80.9
Intermittent access day 15 total infusions0.10.10.30.10.1-0.2-0.1-0.1-0.20.5-0.3-0.6
Intermittent access terminal intake (last 3 days)0.10.10.40.10.2-0.2-0.1-0.2-0.20.7-0.4-0.5
Intermittent access total infusions0.40.51.01.00.90.6-0.80.5-1.00.00.30.4
Intermittent access day 1 locomotion0.10.10.3-0.1-0.0-0.30.3-0.40.10.5-0.2-0.0
Intermittent access day 15 total locomotion4.95.26.6-2.1-2.1-2.42.4-2.52.42.6-2.3-1.6
Intermittent access total locomotion1.41.62.7-1.0-1.1-1.41.3-1.51.31.6-1.4-0.5
Intermittent access standard deviation1.41.41.8-1.3-1.3-1.21.1-1.21.11.1-1.2-1.3
Left kidney weight2.46.99.3-2.3-2.2-2.92.8-2.82.73.1-2.6-2.1
Right kidney weight3.29.111.7-3.1-2.7-3.43.1-3.12.83.4-3.0-2.4
Cocaine induced anxiety0.20.21.2-1.1-0.4-0.50.3-0.10.3-0.10.1-0.3
Post-drug Anxiety0.10.10.3-0.6-0.3-0.0-0.20.2-0.2-0.40.20.3
Baseline Anxiety0.40.51.11.00.40.9-0.80.6-0.6-0.60.30.7
Tail length0.82.64.6-1.9-0.9-2.21.8-1.51.72.0-1.2-0.2
Length with tail1.76.110.4-2.2-1.7-2.92.8-2.72.63.2-2.3-0.8
Length without tail1.22.64.6-1.0-1.3-1.71.9-1.91.82.1-1.8-0.4
Times rat made contact with spout2.12.43.21.71.31.8-1.71.6-1.6-1.71.41.1
Lifetime Intake0.20.20.60.70.50.2-0.50.1-0.60.4-0.10.1
Liver weight, left5.18.210.3-3.1-2.7-3.23.1-2.93.13.0-2.7-1.6
Liver weight, right2.54.27.1-2.7-1.4-2.62.5-1.92.42.2-1.3-0.3
Locomotor activity0.40.61.4-1.2-0.6-0.80.9-0.60.80.4-0.2-0.9
Locomotor testing distance0.10.20.9-0.8-0.4-0.30.3-0.20.2-0.1-0.0-1.0
Locomotor testing rearing1.32.13.3-1.8-1.6-1.51.5-1.41.41.2-1.2-1.2
Locomotion in novel chamber0.81.01.31.11.11.1-0.70.8-1.0-1.11.10.7
Locomotion in novel chamber post-restriction1.82.22.7-1.2-1.5-1.41.5-1.71.41.4-1.6-1.5
Fecal boli incidents, locomotor time 10.10.10.50.4-0.00.2-0.40.2-0.4-0.1-0.10.7
Change in fecal boli incidents, locomotor task0.10.10.2-0.5-0.3-0.30.5-0.30.10.1-0.2-0.5
Time >=10cm from walls, locomotor time 12.92.94.5-2.0-2.1-1.61.8-1.71.81.3-1.6-1.3
Bouts of movement, locomotor time 10.10.10.5-0.30.00.10.00.30.1-0.70.40.5
Total resting periods, locomotor time 10.10.10.3-0.4-0.1-0.10.20.00.3-0.40.20.5
Rest time, locomotor task time 10.00.00.1-0.10.2-0.20.0-0.0-0.10.1-0.1-0.0
Distance moved, locomotor task time 10.40.40.7-0.6-0.8-0.50.6-0.60.70.7-0.7-0.7
Vertical activity count, locomotor time 11.21.32.7-1.2-1.6-0.91.0-1.11.01.0-1.3-0.8
Time >=10cm from walls, locomotor time 23.94.16.6-1.8-2.3-2.01.5-2.01.32.4-2.6-1.9
Bouts of movement, locomotor time 20.60.61.4-1.2-0.9-0.81.0-0.70.90.2-0.40.2
Total resting periods, locomotor time 20.20.20.5-0.7-0.3-0.30.5-0.20.4-0.40.20.6
Rest time, locomotor task time 20.10.10.4-0.6-0.0-0.30.5-0.10.6-0.30.20.0
Distance moved, locomotor task time 21.82.03.9-0.8-1.5-1.31.1-1.51.02.0-1.9-1.3
Vertical activity count, locomotor time 21.11.22.6-0.6-1.3-1.00.6-1.10.51.6-1.6-0.6
Light reinforcement 12.95.36.8-2.6-2.5-2.32.3-2.22.11.9-2.1-2.5
Light reinforcement 23.04.05.2-2.3-2.3-2.12.0-2.01.82.0-1.9-1.5
Bone: marrow area2.75.87.5-2.7-2.5-2.72.5-2.52.32.7-2.4-0.7
Bone: maximum diameter0.20.30.5-0.6-0.1-0.70.6-0.50.50.7-0.30.3
Bone: maximum force1.11.82.6-0.9-1.2-1.31.3-1.51.01.6-1.6-1.5
Bone: maximum moment0.61.01.7-0.5-0.8-1.00.9-1.10.61.3-1.2-1.0
Mean time between licks in bursts0.60.82.5-0.21.00.3-0.50.9-0.5-0.81.31.6
Mean num. licks in bursts0.20.30.90.90.20.7-0.60.4-0.6-0.50.10.3
Cd content in liver0.80.92.0-0.2-1.0-0.70.7-1.10.41.2-1.4-1.1
Co content in liver2.73.25.1-1.4-2.0-1.61.7-1.91.41.7-2.0-2.3
Cu content in liver3.03.75.12.21.82.2-2.12.0-2.0-2.01.70.9
Fe content in liver3.54.25.9-1.6-1.5-2.22.2-2.21.82.4-2.1-2.1
K content in liver1.31.31.90.91.41.0-0.91.2-1.1-1.01.31.3
Mg content in liver3.73.85.71.52.31.7-1.72.0-2.0-1.72.22.4
Mn content in liver0.40.52.7-0.20.60.0-0.20.5-0.6-0.30.71.6
Na content in liver0.10.10.5-0.4-0.1-0.20.4-0.20.70.00.1-0.1
Rb content in liver0.00.10.10.2-0.1-0.1-0.0-0.2-0.20.3-0.30.4
Se content in liver3.44.26.91.52.61.6-1.62.0-1.7-1.82.52.6
Sr content in liver0.20.20.40.70.10.4-0.50.2-0.4-0.2-0.00.6
Zn content in liver0.10.10.20.20.3-0.20.2-0.20.10.5-0.20.2
Bone: minimum diameter0.61.21.7-1.2-1.0-1.31.2-1.11.11.3-1.1-0.2
Time in familiar zone, hab. session 10.10.10.30.50.30.3-0.40.2-0.6-0.10.1-0.2
Time in novel zone, hab. session 10.30.30.5-0.7-0.4-0.60.6-0.40.50.6-0.4-0.4
Total zone transitions, hab. session 12.13.04.31.61.91.8-1.71.8-2.1-1.81.90.4
Total locomotion distance, hab. session 11.62.23.21.41.81.5-1.31.5-1.6-1.61.80.6
Locomotion velocity, hab. session 11.62.23.41.41.81.5-1.41.5-1.6-1.51.80.6
Time in familiar zone, hab. session 20.50.51.50.10.30.7-0.70.9-0.0-1.21.00.7
Time in novel zone, hab. session 20.60.61.70.1-0.4-0.60.6-0.90.11.3-1.2-0.6
Total zone transitions, hab. session 20.20.20.6-0.00.50.3-0.20.4-0.2-0.70.8-0.4
Total locomotion distance, hab. session 21.31.73.40.81.41.3-1.11.4-1.0-1.81.90.5
Locomotion velocity, hab. session 21.62.24.40.91.61.5-1.31.6-1.1-2.02.10.6
Novel to familiar place preference ratio0.10.10.60.20.0-0.20.2-0.3-0.20.5-0.4-0.8
Novelty place preference0.10.10.40.10.0-0.20.2-0.3-0.20.5-0.3-0.7
Time in novel zone, NPP test0.10.10.30.0-0.1-0.30.3-0.4-0.20.6-0.4-0.6
Total zone transitions, NPP test1.62.32.91.41.71.5-1.51.6-1.6-1.61.71.0
Total locomotion distance, NPP test1.41.92.31.51.41.5-1.41.4-1.3-1.41.41.0
Locomotion velocity, NPP test1.82.53.21.61.61.7-1.61.6-1.5-1.81.71.0
Intraocular pressure0.91.31.7-1.0-0.9-1.21.3-1.21.11.3-1.1-1.0
Delta distance traveled before/after self-admin0.50.60.90.90.50.8-0.90.7-0.9-0.60.50.9
Delta ambulatory time before/after self-admin0.50.50.80.60.40.7-0.90.7-0.8-0.60.50.9
Parametrial fat weight3.26.28.1-2.6-2.5-2.42.7-2.42.82.0-2.2-2.5
Pavlov. Cond. lever latency1.21.53.6-1.2-1.9-0.91.0-1.21.50.6-1.3-0.8
Pavlov. Cond. magazine entry latency1.41.82.91.11.71.0-1.11.3-1.5-0.91.41.6
Pavlov. Cond. change in total contacts0.20.20.6-0.30.2-0.50.5-0.30.00.8-0.3-0.5
Pavlov. Cond. index score1.11.43.21.11.80.8-1.01.1-1.5-0.51.21.1
Pavlov. Cond. latency score0.91.22.81.01.70.7-0.91.0-1.3-0.51.11.0
Pavlov. Cond. lever contacts1.21.43.21.31.80.9-1.11.1-1.5-0.51.10.9
Pavlov. Cond. magazine entry number1.62.03.0-1.2-1.7-1.21.3-1.41.51.2-1.6-1.5
Pavlov. Cond. intertrial magazine entries0.10.10.60.8-0.20.4-0.3-0.1-0.20.1-0.4-0.1
Pavlov. Cond. lever-magazine prob. diff.1.11.43.31.21.80.8-1.01.1-1.5-0.51.21.0
Pavlov. Cond. response bias2.42.94.91.62.21.4-1.61.7-1.9-1.11.71.7
Pavlov. Cond. lever latency2.73.64.4-2.1-1.9-2.01.9-1.91.51.8-1.8-2.1
Pavlov. Cond. magazine entry latency0.10.20.60.1-0.3-0.20.2-0.40.40.5-0.40.8
Pavlov. Cond. change in total contacts1.52.13.21.61.31.6-1.51.4-1.2-1.41.31.8
Pavlov. Cond. index score0.81.02.31.20.91.0-1.00.9-0.7-0.80.81.5
Pavlov. Cond. latency score0.50.61.70.90.70.7-0.70.7-0.5-0.60.61.3
Pavlov. Cond. lever contacts1.72.33.21.81.41.7-1.51.5-1.4-1.51.41.4
Pavlov. Cond. magazine entry number0.10.10.3-0.10.30.0-0.10.2-0.2-0.20.3-0.6
Pavlov. Cond. intertrial magazine entries0.30.30.7-0.50.40.2-0.40.7-0.4-0.70.80.8
Pavlov. Cond. lever-magazine prob. diff.0.50.61.80.90.60.8-0.70.7-0.5-0.50.61.3
Pavlov. Cond. response bias1.31.82.81.71.31.4-1.31.2-1.2-1.01.11.6
Time in closed arm before self-admin0.40.50.80.90.50.8-0.60.5-0.6-0.50.50.9
Time in closed arm after self-admin0.10.10.20.40.10.10.2-0.30.20.4-0.2-0.3
Time in open arm before self-admin0.20.30.50.40.70.4-0.50.6-0.5-0.40.60.4
Time in open arm after self-admin2.02.22.81.21.31.4-1.61.7-1.7-1.51.41.6
Bone: periosteal estimation1.53.04.0-1.8-1.6-2.01.8-1.81.62.0-1.8-0.9
Bone: periosteal perimeter0.71.11.9-1.4-1.1-1.21.2-1.11.01.0-0.9-0.5
Bone: post-yield work0.10.10.30.0-0.1-0.30.1-0.3-0.10.5-0.50.3
Progressive ratio test 1 active lever presses0.30.31.01.00.70.6-0.50.3-0.5-0.10.30.6
Progressive ratio test 1 breakpoint0.30.31.01.00.70.6-0.60.3-0.5-0.20.30.5
Progressive ratio test 1 inactive lever presses1.01.12.1-0.9-1.0-1.00.9-1.01.01.0-1.0-1.4
Progressive ratio test 2 active lever presses0.00.00.10.20.00.1-0.0-0.1-0.00.2-0.1-0.2
Progressive ratio test 2 breakpoint0.00.00.10.20.10.1-0.1-0.0-0.10.20.0-0.3
Progressive ratio test 2 inactive lever presses0.10.20.40.60.60.3-0.30.3-0.3-0.10.40.5
Incentive Sensitization - Responses0.20.20.70.10.50.5-0.30.6-0.2-0.70.80.1
Incentive Sensitization - Breakpoint0.10.10.3-0.20.20.2-0.00.30.1-0.40.5-0.2
Sum of active levers in priming session hrs 5-61.01.01.41.21.10.9-1.21.0-1.2-0.60.70.9
Progressive ratio5.26.17.4-2.6-2.6-2.42.6-2.52.72.1-2.3-2.3
Food seeking constrained by brief footshock0.10.20.70.80.20.6-0.30.2-0.0-0.10.20.5
Seeking ratio, punishment vs. effort3.54.25.42.32.22.1-2.22.0-2.2-1.71.91.8
Retroperitoneal fat weight1.13.54.8-1.5-1.8-1.82.1-2.21.72.1-2.0-1.6
Reaction time number correct1.11.62.8-1.2-1.5-1.11.2-1.21.40.9-1.2-1.7
Reaction time mean minus median0.20.20.5-0.7-0.1-0.70.4-0.20.40.5-0.20.7
Reaction time mean minus median AUC0.10.21.3-0.10.1-0.30.10.00.00.3-0.11.1
Reaction time num false alarms0.10.10.3-0.50.2-0.20.30.10.4-0.30.50.3
Reaction time num false alarms AUC0.30.41.1-0.10.70.3-0.20.6-0.0-0.81.10.8
Reaction time trials correct on left1.11.62.8-1.2-1.5-1.11.2-1.21.40.9-1.2-1.7
Reaction time trials on left1.11.62.5-1.1-1.4-1.11.2-1.21.40.8-1.2-1.6
Reaction time mean0.10.10.7-0.3-0.2-0.30.0-0.0-0.10.4-0.30.8
Reaction time mean AUC0.20.30.5-0.5-0.5-0.60.3-0.40.20.7-0.60.6
Median of all reaction times0.10.10.2-0.3-0.4-0.40.2-0.20.00.4-0.40.5
Reaction time omissions0.20.20.9-0.9-0.4-0.60.5-0.20.50.2-0.10.4
Reaction time false alarm rate1.21.73.00.71.61.0-1.01.3-0.9-1.21.71.7
Reaction time premature initiation rate0.10.10.30.10.20.3-0.20.3-0.5-0.40.30.1
Reaction time premature initiations0.30.40.9-0.6-0.8-0.40.6-0.50.40.3-0.6-0.9
Std. dev. reaction times0.20.21.8-0.20.2-0.2-0.00.2-0.00.20.11.4
Reaction time trials completed1.11.62.5-1.1-1.4-1.11.2-1.21.40.8-1.2-1.6
Reaction time trials AUC1.11.62.6-1.2-1.5-1.11.2-1.21.30.8-1.2-1.6
Run reversals in cocaine runway, females0.10.10.50.70.20.2-0.40.1-0.50.2-0.3-0.1
Run reversals in cocaine runway, males0.20.10.4-0.50.1-0.60.4-0.10.50.5-0.20.1
Latency to leave start box in cocaine runway0.50.50.70.70.70.8-0.80.8-0.7-0.70.70.5
Latency to leave start box in cocaine runway, F0.50.60.70.70.70.8-0.90.8-0.6-0.80.80.7
Latency to leave start box in cocaine runway, M0.00.00.3-0.10.1-0.00.00.0-0.00.10.0-0.6
Std. dev. time between licks in bursts0.20.20.6-0.80.5-0.50.40.10.30.20.50.4
Total sessions with >9 infusions0.20.20.60.80.50.4-0.40.2-0.50.10.10.5
Short access day 1 total inactive lever presses0.30.30.60.80.70.4-0.50.4-0.5-0.20.30.8
Short access day 10 total inactive lever presses1.11.23.8-2.0-1.0-1.11.2-0.71.40.1-0.2-1.1
Short access day 1 total infusions2.22.33.51.91.81.4-1.51.4-1.6-1.01.31.6
Short access day 10 total infusions0.00.00.00.20.10.1-0.10.1-0.00.10.10.2
Short access total infusions0.20.30.80.90.70.4-0.60.3-0.60.10.20.4
Short access day 1 locomotion0.10.10.30.10.40.2-0.10.30.0-0.30.50.1
Short access day 10 total locomotion0.30.30.8-0.10.40.30.10.30.3-0.70.90.9
Short access total locomotion0.10.10.2-0.2-0.1-0.10.3-0.20.50.10.00.3
One hour access (0.3 mA shock)0.70.81.10.71.00.8-1.01.0-0.9-0.91.00.6
Compulsive drug intake2.72.73.61.31.41.6-1.91.8-1.8-1.91.61.6
One hour access (shock baseline)0.10.10.60.0-0.0-0.40.3-0.40.30.8-0.4-0.0
Social response proportion0.00.00.20.10.20.1-0.10.2-0.1-0.10.20.4
Social responses0.10.10.2-0.3-0.00.00.10.10.4-0.50.40.2
Social time0.20.20.9-0.90.1-0.20.10.30.1-0.50.70.5
Soleus weight0.20.61.4-1.00.1-1.00.8-0.40.80.8-0.01.2
Bone: stiffness1.01.62.2-1.1-1.3-1.31.2-1.30.91.3-1.4-1.5
Tibialis anterior weight0.62.13.01.21.21.6-1.51.6-1.4-1.71.61.2
Time to tail flick, vehicle, before self-admin4.64.78.4-2.9-2.1-2.32.4-1.92.41.6-1.5-2.1
Time to tail flick, vehicle, after self-admin0.00.00.2-0.0-0.00.2-0.20.1-0.1-0.40.20.2
Time to tail flick, test, before self-admin0.30.31.2-0.6-0.3-0.20.8-0.41.1-0.20.2-0.6
Time to tail flick, test, after self-admin0.10.10.2-0.4-0.1-0.30.2-0.10.40.2-0.0-0.3
Delta time to tail flick, vehicle, before/after SA3.02.95.42.31.51.9-2.01.5-2.0-1.31.11.4
Delta time to tail flick, test, before/after SA0.80.71.4-0.8-0.9-1.00.5-0.80.31.1-1.2-0.9
Tibia length2.67.49.4-2.9-2.6-3.12.9-2.82.83.0-2.6-1.6
Ambulatory time before self-admin1.21.22.4-1.4-1.0-1.11.5-1.01.60.7-0.6-0.8
Ambulatory time after self-admin0.30.30.9-0.9-0.6-0.40.7-0.40.9-0.10.00.1
Bone: tissue strength0.00.00.20.4-0.10.2-0.20.0-0.0-0.1-0.2-0.0
Total heroin consumption0.10.10.40.10.10.3-0.20.3-0.2-0.40.40.6
Bone: trabecular number1.01.62.61.41.21.3-1.41.2-1.6-1.21.10.8
Bone: trabecular spacing1.92.43.0-1.6-1.6-1.61.7-1.61.71.5-1.5-1.1
Bone: trabecular thickness0.10.20.50.0-0.2-0.40.3-0.50.20.7-0.6-0.3
Bone: trabecular tissue density0.00.10.20.10.3-0.20.2-0.10.50.3-0.00.3
Water consumed over 24 hours1.21.41.91.10.81.3-1.31.3-0.9-1.31.11.4
Number of responses in last shaping day3.33.45.22.32.31.7-2.11.7-2.2-1.01.51.6