Lgi1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Lgi1	0.04	0.03	2.1e-03	0.01	0.01	0.01	0.02	1.0e-02	2.0e-02	1.1e-02	3.8e-03
2	Brain	gene expression	Lgi1	0.04	0.02	1.2e-04	0.03	0.03	0.02	0.03	2.2e-03	3.4e-04	4.3e-03	1.6e-03
3	Adipose	gene expression	Lgi1	0.03	0.02	3.6e-04	0.02	0.02	0.02	0.02	5.6e-03	1.8e-03	1.8e-03	4.1e-03
4	Brain	mRNA stability	Lgi1	0.03	0.02	5.8e-03	0.01	0.02	0.02	0.01	1.7e-02	7.4e-03	3.4e-03	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4
Bone: apparent density	2.7	5.0	6.6	-2.5	2.6	2.1	1.7
Area under the delay curve	0.5	0.7	1.4	0.8	-0.3	-0.9	-1.2
BMI with tail	0.3	1.0	3.0	-1.7	0.7	0.7	0.4
BMI without tail	0.0	0.1	0.3	-0.6	-0.2	-0.2	-0.1
Body weight	0.2	0.8	1.1	-1.0	0.6	0.8	1.1
Weight adjusted by age	0.0	0.0	0.1	-0.0	0.0	-0.1	-0.2
Bone surface	2.8	5.6	7.6	-2.8	2.5	2.3	1.9
Bone volume	2.8	5.6	5.9	-2.4	2.4	2.4	2.2
Breakpoint value in progressive ratio session	0.2	0.4	1.0	0.3	0.2	-0.7	-1.0
Number of licking bursts	0.7	2.2	3.1	1.6	-1.0	-1.4	-1.8
Context. condit. distance diff. score	1.7	2.0	2.4	-1.2	1.6	1.4	1.5
Locomotion velocity, session 1	2.6	2.9	3.9	1.8	-1.2	-1.7	-2.0
Locomotion distance, session 1	1.2	1.6	2.2	1.4	-0.8	-1.3	-1.5
Locomotion velocity, session 2	0.6	0.8	1.6	-1.0	1.3	0.2	-0.7
Locomotion distance, session 2	0.2	0.3	1.0	-0.3	0.3	-0.4	-1.0
Locomotion velocity, session 3	0.3	0.3	0.4	-0.5	0.6	0.5	0.5
Locomotion distance, session 3	0.5	0.6	1.2	-0.3	0.5	0.9	1.1
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	0.0	0.3	0.2	0.2
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.1	0.4	0.2	0.1
Locomotion velocity, session 7	3.4	3.7	5.3	-1.5	1.9	2.3	2.0
Locomotion distance, session 7	2.6	3.3	4.2	-1.6	1.7	2.1	1.8
Stereotopy head waving bouts, day 7	0.4	0.4	0.6	0.7	-0.1	-0.7	-0.8
Stereotopy head waving duration, day 7	0.1	0.1	0.4	0.6	-0.1	-0.2	-0.1
Locomotion velocity, session 8	0.2	0.3	0.6	-0.6	0.8	0.3	0.3
Locomotion distance, session 8	0.8	1.2	2.5	-1.4	1.6	0.7	0.1
Degree of sensitization distance	0.3	0.3	0.7	-0.7	0.9	0.3	0.0
Degree of sensitization stereotypy	0.9	1.0	1.3	1.0	-0.5	-1.1	-1.1
Conditioned locomotion	0.5	0.6	1.4	-0.4	-0.3	0.9	1.2
Cocaine response after cond. corrected	0.0	0.0	0.1	-0.0	-0.2	-0.2	-0.3
Cocaine response after cond. not corrected	0.0	0.0	0.1	-0.0	0.0	-0.3	-0.2
Cocaine response before conditioning	0.1	0.2	0.3	0.5	0.2	-0.5	-0.2
Saline control response	2.3	3.2	4.5	1.9	-1.2	-2.1	-1.8
Bone: connectivity density	4.2	6.7	9.3	-3.0	2.8	2.5	1.9
Bone: cortical apparent density	0.8	1.3	1.9	1.2	-0.7	-1.3	-1.4
Bone: cortical area	0.9	1.5	3.1	-0.8	0.9	1.2	1.8
Bone: cortical porosity	1.3	1.4	2.7	-1.3	1.6	0.9	0.3
Bone: cortical porosity	1.4	1.6	2.7	-1.4	1.7	1.1	0.7
Bone: cortical thickness	1.1	1.8	3.2	1.8	-1.3	-1.3	-0.6
Bone: cortical thickness	2.6	3.2	4.0	2.0	-1.4	-2.0	-1.7
Bone: cortical tissue density	0.8	1.3	2.0	1.1	-0.6	-1.3	-1.4
Condit. Reinf. active minus inactive responses	0.0	0.1	0.2	0.4	-0.1	-0.1	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.4	-0.4	-0.1	-0.2
Condit. Reinf. active responses	0.0	0.0	0.2	0.4	-0.1	0.0	0.1
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.2	0.0	-0.1	0.1
Incentive salience index mean	0.4	0.6	0.8	0.9	-0.8	-0.7	-0.6
Condit. Reinf. lever presses	1.5	2.3	2.7	1.6	-1.6	-1.6	-1.2
Condit. Reinf. active minus inactive responses	2.2	3.4	3.9	-1.9	1.6	2.0	1.9
Condit. Reinf. active-inactive response ratio	1.1	1.7	2.2	-1.5	1.1	1.5	1.0
Condit. Reinf. active responses	0.7	1.0	2.2	-0.6	0.4	1.0	1.5
Condit. Reinf. inactive responses	0.7	1.0	1.7	1.3	-1.2	-0.9	0.1
Condit. Reinf. lever presses	0.3	0.4	0.6	0.6	-0.6	-0.7	-0.5
Condit. Reinf. lever reinforcers received	0.3	0.4	1.0	-0.4	0.2	0.6	1.0
Conditioned reinforcement - actives	0.0	0.2	0.7	-0.2	0.8	-0.1	-0.1
Conditioned reinforcement - inactives	0.4	1.0	3.1	-0.6	1.8	0.6	0.6
Conditioned locomotion	0.1	0.1	0.3	0.5	0.2	-0.4	0.1
Patch foraging indifference point 0 sec	0.4	1.1	1.6	1.1	-1.3	-1.0	-0.8
Patch foraging indifference point AUC	2.4	5.7	7.9	2.5	-1.8	-2.8	-2.3
Delay disc. indifference point, 0s delay	1.0	1.1	2.1	-1.3	1.4	0.8	0.3
Delay disc. indifference point, 16s delay	0.4	0.6	1.1	0.5	-0.3	-1.0	-1.0
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.0	0.1	-0.3	-0.8
Delay disc. indifference point, 24s delay	0.9	1.4	2.0	1.4	-0.7	-1.2	-1.2
Delay disc. indifference point, 4s delay	0.8	0.9	2.2	0.4	-0.1	-1.1	-1.5
Delay disc. indifference point, 8s delay	1.5	2.5	3.6	1.9	-1.4	-1.4	-1.6
Indifference point function ln k	2.1	6.4	8.0	-2.6	2.1	2.8	2.6
Indifference point function log k	2.1	6.4	8.0	-2.6	2.1	2.8	2.6
Patch foraging total patch changes 0 sec	0.4	1.1	1.7	1.1	-1.3	-1.0	-0.7
Patch foraging total patch changes 12 sec	5.8	7.8	9.0	3.0	-2.5	-2.9	-2.7
Patch foraging total patch changes 18 sec	1.0	2.3	3.2	1.3	-1.2	-1.8	-1.7
Patch foraging total patch changes 24 sec	0.3	1.0	1.4	1.2	-0.9	-1.0	-0.8
Patch foraging total patch changes 6 sec	4.4	7.5	8.6	2.9	-2.5	-2.8	-2.6
Patch foraging time to switch 0 sec	0.4	1.5	2.6	1.1	-1.1	-1.1	-1.6
Patch foraging water rate 0 sec	0.6	2.2	2.9	-1.3	1.4	1.5	1.7
Patch foraging water rate 12 sec	0.2	0.8	1.6	-0.5	0.8	1.0	1.3
Patch foraging water rate 18 sec	1.0	2.2	2.5	-1.4	1.6	1.6	1.4
Patch foraging water rate 24 sec	0.9	1.2	1.4	-1.1	1.1	1.1	1.2
Patch foraging water rate 6 sec	0.1	0.2	0.3	-0.5	0.4	0.2	0.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.1	-0.4	-0.4	-0.2
Distance traveled before self-admin	0.4	0.9	1.6	-1.3	1.2	0.7	0.1
Distance traveled after self-admin	1.1	1.9	3.6	-1.7	1.9	1.1	0.3
Extensor digitorum longus weight	0.4	1.5	1.6	-1.1	1.2	1.3	1.2
Bone: elastic displacement	0.1	0.1	0.3	0.5	-0.3	0.1	-0.3
Bone: elastic work	0.2	0.2	0.5	-0.4	0.7	0.5	0.1
Bone: endosteal estimation	5.5	13.3	14.8	-3.9	3.7	3.6	3.4
Bone: endosteal perimeter	4.6	11.3	13.7	-3.7	3.4	3.3	3.0
Epididymis fat weight	0.6	2.9	4.1	-1.6	1.1	1.9	2.0
Delta time in closed arm before/after self-admin	0.4	0.4	0.9	1.0	-0.7	-0.3	0.2
Delta time in open arm before/after self-admin	1.3	1.5	3.4	-1.8	1.5	0.3	-0.5
Diff in mean of infusions in LGA sessions	0.9	1.6	2.3	-1.2	1.5	1.3	1.0
Delay discount exponential model param	0.6	0.8	1.6	-0.8	0.3	0.9	1.3
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.2	0.2	0.2	0.5
Active lever presses in extinction session 6	3.7	3.7	7.1	-2.3	2.7	1.5	0.5
Bone: final force	0.2	0.3	0.3	-0.6	0.5	0.3	0.6
Bone: final moment	0.2	0.3	0.6	-0.5	0.4	0.5	0.8
Food consumed during 24 hour testing period	0.1	0.2	0.5	0.7	-0.4	-0.3	0.2
Glucose	0.2	0.3	0.8	-0.2	0.2	0.5	0.9
Heart weight	0.4	0.6	1.1	0.8	-1.1	0.2	0.8
Delay discount hyperbolic model param	0.5	0.7	1.4	-0.7	0.3	0.8	1.2
Intermittent access intake day 1-15 change	0.5	2.8	4.7	-2.2	1.6	1.4	1.4
Intermittent access intake escalation	0.7	3.8	5.8	-2.4	1.9	1.7	1.6
Intermittent access intake escalation 2	2.7	4.6	6.3	-2.5	2.4	2.0	1.5
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.4	0.5	0.2	-0.1
Intermitt. access day 15 inactive lever presses	0.2	0.8	1.2	-0.2	0.9	1.1	1.1
Intermitt. access escalation Index	0.1	0.4	0.8	0.1	-0.1	0.8	0.9
Intermittent access day 1 total infusions	0.1	0.3	1.2	-0.2	1.1	0.1	0.3
Intermittent access day 15 total infusions	1.1	2.7	3.1	-1.6	1.8	1.4	1.8
Intermittent access terminal intake (last 3 days)	1.3	2.2	3.3	-1.3	1.8	1.3	1.5
Intermittent access total infusions	0.8	0.9	1.5	-0.6	1.2	0.8	1.1
Intermittent access day 1 locomotion	0.2	0.4	0.6	-0.6	0.8	0.3	0.6
Intermittent access day 15 total locomotion	0.0	0.2	0.3	0.1	0.4	-0.5	-0.4
Intermittent access total locomotion	0.4	0.5	1.4	-0.6	1.2	0.1	0.1
Intermittent access standard deviation	0.6	3.2	4.3	-2.0	2.1	1.6	1.5
Left kidney weight	0.0	0.3	0.9	0.9	-0.6	-0.3	0.0
Right kidney weight	0.3	1.9	3.5	1.9	-1.6	-1.1	-0.6
Cocaine induced anxiety	0.6	1.8	2.4	-1.6	1.2	1.3	1.2
Post-drug Anxiety	0.3	0.4	0.8	-0.3	-0.4	0.6	0.9
Baseline Anxiety	0.7	1.1	2.5	1.3	-1.6	-0.5	-0.1
Tail length	0.0	0.2	0.7	0.3	0.1	0.2	0.9
Length with tail	0.0	0.2	0.4	0.6	0.1	0.0	0.7
Length without tail	0.2	1.1	1.6	-0.6	1.3	1.0	1.1
Times rat made contact with spout	0.2	0.2	0.6	-0.4	0.8	0.3	0.2
Lifetime Intake	0.4	0.5	1.2	-0.5	1.1	0.5	0.7
Liver weight, left	0.1	0.1	0.2	0.3	-0.4	-0.2	0.2
Liver weight, right	0.5	1.0	1.2	-1.1	0.9	0.8	1.1
Locomotor activity	0.0	0.1	0.1	-0.2	0.4	0.3	-0.1
Locomotor testing distance	0.0	0.1	0.3	0.2	0.2	-0.1	-0.6
Locomotor testing rearing	0.3	0.9	1.9	-1.0	1.4	0.9	0.3
Locomotion in novel chamber	3.3	4.4	5.8	-2.4	2.3	2.1	1.4
Locomotion in novel chamber post-restriction	0.1	0.3	0.7	-0.2	0.1	-0.8	-0.7
Fecal boli incidents, locomotor time 1	0.4	1.1	2.0	-1.0	1.4	0.8	0.8
Change in fecal boli incidents, locomotor task	1.2	1.3	1.6	0.9	-1.2	-1.3	-1.1
Time >=10cm from walls, locomotor time 1	0.3	0.4	1.3	-0.0	0.4	0.4	1.1
Bouts of movement, locomotor time 1	0.2	0.3	0.6	0.8	-0.3	-0.4	-0.5
Total resting periods, locomotor time 1	0.4	0.5	0.9	0.9	-0.2	-0.6	-0.7
Rest time, locomotor task time 1	0.0	0.1	0.2	0.2	0.4	-0.1	-0.4
Distance moved, locomotor task time 1	0.1	0.2	0.5	0.4	-0.7	-0.3	0.1
Vertical activity count, locomotor time 1	0.0	0.2	0.7	-0.1	-0.8	-0.2	0.3
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	0.0	0.4	0.4	0.6
Bouts of movement, locomotor time 2	1.0	3.3	5.0	1.9	-0.9	-2.0	-2.2
Total resting periods, locomotor time 2	0.8	3.3	5.0	1.8	-0.8	-2.0	-2.2
Rest time, locomotor task time 2	0.4	0.7	1.6	0.6	-0.2	-0.8	-1.3
Distance moved, locomotor task time 2	0.7	1.0	2.3	-0.5	0.4	1.1	1.5
Vertical activity count, locomotor time 2	0.2	0.5	1.0	-0.7	0.2	0.7	1.0
Light reinforcement 1	0.2	0.8	1.1	0.9	-0.6	-0.8	-1.1
Light reinforcement 2	0.9	2.1	3.4	1.5	-1.1	-1.2	-1.8
Bone: marrow area	5.6	13.6	15.2	-3.9	3.7	3.7	3.5
Bone: maximum diameter	5.6	11.3	12.1	-3.5	3.4	3.3	3.3
Bone: maximum force	0.8	1.6	2.2	-1.4	1.5	1.0	1.1
Bone: maximum moment	0.9	1.7	1.8	-1.3	1.4	1.2	1.3
Mean time between licks in bursts	0.1	0.5	1.3	0.6	-1.1	-0.3	0.3
Mean num. licks in bursts	1.4	3.7	4.4	-2.1	1.7	1.8	2.1
Cd content in liver	1.4	1.5	2.4	1.5	-1.4	-0.9	-1.0
Co content in liver	2.2	2.6	4.7	2.1	-2.2	-1.0	-0.3
Cu content in liver	5.8	6.9	9.7	2.4	-2.0	-2.8	-3.1
Fe content in liver	2.5	3.0	3.9	1.5	-1.7	-1.7	-2.0
K content in liver	0.7	0.7	1.8	-0.3	0.4	-0.9	-1.4
Mg content in liver	0.5	0.6	1.9	0.0	-0.0	-0.7	-1.4
Mn content in liver	2.6	2.9	6.0	1.0	-0.7	-2.0	-2.4
Na content in liver	1.2	1.3	2.8	0.5	-0.6	-1.4	-1.7
Rb content in liver	0.1	0.2	0.4	-0.0	0.3	0.6	0.4
Se content in liver	20.9	24.7	31.8	4.5	-4.5	-5.2	-5.6
Sr content in liver	0.5	0.4	0.7	0.5	-0.4	-0.8	-0.7
Zn content in liver	2.5	2.9	5.1	1.4	-1.3	-1.7	-2.3
Bone: minimum diameter	7.6	14.5	18.8	-3.5	3.4	3.9	4.3
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.4	0.2	0.3	0.0
Time in novel zone, hab. session 1	0.3	0.3	0.5	0.4	-0.3	-0.7	-0.7
Total zone transitions, hab. session 1	0.1	0.2	0.6	-0.0	0.3	-0.3	-0.8
Total locomotion distance, hab. session 1	1.3	1.9	3.3	1.1	-0.9	-1.5	-1.8
Locomotion velocity, hab. session 1	2.4	3.4	4.6	1.7	-1.4	-2.0	-2.2
Time in familiar zone, hab. session 2	0.4	0.5	0.9	1.0	-0.9	-0.3	0.1
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.1	0.3	-0.1	-0.3
Total zone transitions, hab. session 2	0.7	0.9	1.1	1.0	-0.9	-1.0	-0.9
Total locomotion distance, hab. session 2	1.1	1.5	2.0	1.4	-1.3	-1.2	-1.0
Locomotion velocity, hab. session 2	1.3	1.7	1.9	1.3	-1.2	-1.4	-1.3
Novel to familiar place preference ratio	2.9	3.8	7.0	-2.2	2.6	1.6	0.9
Novelty place preference	3.1	4.0	7.3	-2.3	2.7	1.6	0.9
Time in novel zone, NPP test	3.3	4.0	7.2	-2.2	2.7	1.6	1.0
Total zone transitions, NPP test	0.7	1.0	1.2	1.1	-1.0	-1.0	-0.9
Total locomotion distance, NPP test	2.2	3.1	3.5	1.9	-1.6	-1.9	-1.7
Locomotion velocity, NPP test	2.0	2.8	3.4	1.7	-1.5	-1.8	-1.6
Intraocular pressure	0.4	0.6	1.1	1.0	-0.7	-0.8	-0.6
Delta distance traveled before/after self-admin	1.2	1.3	1.6	-1.1	1.3	1.1	1.1
Delta ambulatory time before/after self-admin	1.3	2.2	2.5	-1.3	1.5	1.6	1.6
Parametrial fat weight	0.4	1.0	1.7	1.3	-1.2	-1.0	-0.3
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	-0.4	-0.1	0.1
Pavlov. Cond. magazine entry latency	0.5	0.6	1.1	1.0	-0.9	-0.7	-0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.2	-0.2	0.2	0.2
Pavlov. Cond. index score	0.2	0.3	0.5	0.7	-0.4	-0.6	-0.6
Pavlov. Cond. latency score	0.2	0.2	0.4	0.6	-0.3	-0.4	-0.5
Pavlov. Cond. lever contacts	0.2	0.2	0.2	0.5	-0.3	-0.4	-0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.4	0.4	-0.0	-0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.3	-0.1	0.1	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	0.7	-0.4	-0.5	-0.5
Pavlov. Cond. response bias	0.1	0.1	0.2	0.4	-0.4	-0.1	-0.1
Pavlov. Cond. lever latency	0.9	1.3	1.7	-1.2	1.3	1.2	0.7
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	0.6	-0.5	0.1	0.4
Pavlov. Cond. change in total contacts	0.2	0.4	0.6	0.7	-0.8	-0.7	-0.2
Pavlov. Cond. index score	0.4	0.6	1.1	1.0	-0.9	-0.7	-0.1
Pavlov. Cond. latency score	0.3	0.4	0.8	0.9	-0.7	-0.5	0.1
Pavlov. Cond. lever contacts	1.1	1.6	2.1	1.4	-1.5	-1.3	-0.7
Pavlov. Cond. magazine entry number	1.1	1.5	2.7	-1.7	1.4	1.0	0.5
Pavlov. Cond. intertrial magazine entries	0.6	1.4	2.3	-1.5	1.3	1.0	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.5	0.8	0.9	-0.8	-0.7	-0.1
Pavlov. Cond. response bias	1.0	1.4	1.9	1.4	-1.4	-1.1	-0.6
Time in closed arm before self-admin	0.4	0.6	1.1	-0.4	1.0	1.0	0.4
Time in closed arm after self-admin	0.2	0.2	0.6	0.8	-0.3	-0.1	-0.1
Time in open arm before self-admin	0.1	0.2	0.5	0.4	-0.7	0.0	0.2
Time in open arm after self-admin	0.4	0.4	0.8	-0.8	0.4	-0.4	-0.9
Bone: periosteal estimation	3.6	8.5	8.8	-3.0	2.9	2.8	2.9
Bone: periosteal perimeter	3.2	6.4	6.7	-2.6	2.4	2.5	2.6
Bone: post-yield work	1.2	2.1	2.6	-1.6	1.5	1.3	1.4
Progressive ratio test 1 active lever presses	0.1	0.2	0.5	-0.4	0.7	-0.3	-0.3
Progressive ratio test 1 breakpoint	0.1	0.2	0.3	-0.2	0.6	-0.5	-0.4
Progressive ratio test 1 inactive lever presses	0.3	0.7	2.0	-0.5	1.4	0.7	0.5
Progressive ratio test 2 active lever presses	1.1	1.6	4.0	-0.8	2.0	0.8	1.0
Progressive ratio test 2 breakpoint	1.2	1.6	4.0	-0.7	2.0	0.9	1.0
Progressive ratio test 2 inactive lever presses	0.2	0.7	2.4	-0.4	1.6	0.4	0.3
Incentive Sensitization - Responses	0.9	2.4	5.1	-0.9	2.3	1.3	1.4
Incentive Sensitization - Breakpoint	1.0	2.2	4.6	-0.8	2.1	1.3	1.4
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.4	-0.6	-0.2	-0.5
Progressive ratio	0.1	0.3	0.7	0.6	-0.9	0.2	0.3
Food seeking constrained by brief footshock	0.1	0.1	0.4	0.6	0.2	-0.3	-0.2
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	0.3	0.4	-0.7	-0.8
Retroperitoneal fat weight	0.1	0.4	0.7	0.8	-0.6	0.2	0.7
Reaction time number correct	1.1	4.0	6.3	-2.5	1.9	1.9	1.4
Reaction time mean minus median	0.1	0.8	2.1	0.1	-0.1	1.0	1.4
Reaction time mean minus median AUC	0.1	0.7	1.6	0.1	-0.4	0.9	1.3
Reaction time num false alarms	0.0	0.1	0.1	0.3	-0.2	-0.2	0.2
Reaction time num false alarms AUC	0.0	0.1	0.1	0.3	-0.2	-0.2	0.3
Reaction time trials correct on left	1.1	4.0	6.3	-2.5	1.9	1.9	1.4
Reaction time trials on left	1.1	3.9	6.0	-2.5	1.9	1.9	1.5
Reaction time mean	0.5	1.1	2.4	1.6	-1.3	-0.4	0.2
Reaction time mean AUC	0.5	1.3	2.5	1.6	-1.5	-0.7	-0.1
Median of all reaction times	0.7	1.1	2.5	1.6	-1.3	-0.6	-0.1
Reaction time omissions	0.8	1.4	3.2	-0.1	0.0	1.5	1.8
Reaction time false alarm rate	0.9	1.2	2.2	1.5	-1.1	-1.1	-0.4
Reaction time premature initiation rate	0.4	0.7	1.5	1.2	-0.9	-0.6	0.0
Reaction time premature initiations	0.1	0.3	0.9	-0.0	0.1	0.5	0.9
Std. dev. reaction times	0.3	0.9	1.8	0.9	-0.9	0.6	1.3
Reaction time trials completed	1.1	3.9	6.0	-2.5	1.9	1.9	1.5
Reaction time trials AUC	1.0	3.5	5.4	-2.3	1.8	1.9	1.4
Run reversals in cocaine runway, females	0.4	0.5	1.2	0.5	-0.2	-0.7	-1.1
Run reversals in cocaine runway, males	3.1	3.5	4.6	1.9	-1.8	-2.1	-1.5
Latency to leave start box in cocaine runway	1.9	2.6	4.3	-1.2	1.1	1.9	2.1
Latency to leave start box in cocaine runway, F	2.8	3.5	4.0	-1.9	1.7	2.0	1.9
Latency to leave start box in cocaine runway, M	0.3	0.3	0.9	0.1	-0.1	0.6	0.9
Std. dev. time between licks in bursts	1.3	2.4	4.3	1.5	-2.1	-1.4	-1.0
Total sessions with >9 infusions	0.3	0.3	0.7	0.3	-0.2	-0.8	-0.7
Short access day 1 total inactive lever presses	0.8	1.5	2.8	-1.5	1.7	1.0	0.2
Short access day 10 total inactive lever presses	0.0	0.1	0.2	0.2	0.1	0.4	0.3
Short access day 1 total infusions	0.3	0.6	1.2	0.6	-0.3	-1.1	-0.9
Short access day 10 total infusions	0.8	1.3	1.9	1.4	-0.8	-1.2	-1.0
Short access total infusions	0.1	0.1	0.3	0.0	0.5	-0.3	-0.3
Short access day 1 locomotion	0.1	0.2	0.2	-0.4	0.5	-0.1	-0.5
Short access day 10 total locomotion	0.0	0.2	0.4	0.1	-0.1	-0.5	-0.6
Short access total locomotion	0.1	0.2	0.6	0.2	0.1	-0.4	-0.8
One hour access (0.3 mA shock)	3.5	4.1	6.9	-1.6	2.6	1.8	1.9
Compulsive drug intake	1.3	2.0	3.4	-0.7	0.9	1.8	1.8
One hour access (shock baseline)	0.1	0.3	0.8	-0.5	0.9	0.0	0.3
Social response proportion	2.4	3.0	4.8	-2.2	1.9	1.6	1.0
Social responses	0.5	0.7	1.1	-1.0	1.0	0.6	0.5
Social time	0.2	0.4	0.7	0.0	-0.4	-0.8	-0.8
Soleus weight	1.6	4.8	5.5	-2.1	2.0	2.3	2.3
Bone: stiffness	1.1	2.0	2.7	-1.5	1.6	1.1	1.4
Tibialis anterior weight	0.8	2.9	3.9	-1.8	2.0	1.6	1.4
Time to tail flick, vehicle, before self-admin	0.6	0.8	1.9	0.4	-0.2	-0.9	-1.4
Time to tail flick, vehicle, after self-admin	0.2	0.4	1.0	-0.7	1.0	0.4	0.2
Time to tail flick, test, before self-admin	0.8	0.9	1.8	-0.8	1.3	0.8	0.9
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.1	0.3	0.3	-0.2
Delta time to tail flick, vehicle, before/after SA	1.3	1.4	1.9	-1.2	1.4	1.1	1.1
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.5	-0.5	-0.3	-0.6
Tibia length	0.1	0.2	0.5	0.7	-0.6	-0.2	0.0
Ambulatory time before self-admin	0.2	0.7	1.4	-1.2	1.0	0.5	-0.2
Ambulatory time after self-admin	2.6	4.1	7.0	-2.4	2.6	1.8	0.8
Bone: tissue strength	0.4	0.4	0.9	-0.2	0.2	0.7	1.0
Total heroin consumption	0.1	0.1	0.1	0.2	0.3	-0.3	-0.3
Bone: trabecular number	1.8	3.4	4.2	-2.0	2.1	1.8	1.5
Bone: trabecular spacing	1.2	1.7	3.1	1.8	-1.6	-1.0	-0.4
Bone: trabecular thickness	2.0	2.7	3.0	-1.6	1.7	1.7	1.6
Bone: trabecular tissue density	0.5	0.9	1.4	-1.2	1.0	0.8	0.8
Water consumed over 24 hours	0.4	0.7	2.0	-0.6	1.4	0.5	0.3
Number of responses in last shaping day	0.2	0.2	0.5	0.6	-0.7	-0.2	-0.2