Hub : Genes

Lgalsl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Lgalsl 0.04 0.03 2.7e-03 0.01 0.02 0.01 0.02 2.3e-03 1.7e-03 4.3e-03 9.7e-04
2 Adipose mRNA stability Lgalsl 0.03 0.02 3.2e-03 0.01 0.01 0.01 0.01 5.3e-02 1.9e-02 1.1e-02 4.8e-02
3 PL intron excision ratio chr14_99205004_99205629 0.05 0.03 9.1e-04 0.01 0.01 0.01 0 2.3e-02 1.1e-02 1.2e-02 1.6e-01
4 NAcc gene expression Lgalsl 0.06 0.03 1.1e-08 0.06 0.05 0.05 0.03 1.2e-09 1.8e-08 1.7e-08 1.1e-05
5 Brain gene expression Lgalsl 0.36 0.09 0.0e+00 0.27 0.29 0.32 0.32 6.0e-25 1.4e-27 2.1e-30 3.0e-30
6 IC gene expression Lgalsl 0.18 0.07 1.8e-06 0.06 0.14 0.13 0.11 2.2e-03 2.4e-06 5.5e-06 2.0e-05
7 Adipose gene expression Lgalsl 0.44 0.11 0.0e+00 0.25 0.33 0.35 0.35 1.9e-27 7.1e-38 5.9e-40 4.4e-40
8 Liver gene expression Lgalsl 0.2 0.07 0.0e+00 0.16 0.18 0.18 0.17 9.5e-18 7.0e-20 3.7e-19 1.3e-18
9 IC intron excision ratio chr14_99204101_99204697 0.14 0.08 5.0e-04 0.07 0.07 0.05 0.04 6.6e-04 4.8e-04 4.2e-03 9.5e-03
10 IC intron excision ratio chr14_99204785_99204933 0.14 0.09 1.4e-03 0.03 0.06 0.02 0.03 1.8e-02 1.7e-03 5.8e-02 1.8e-02
11 pVTA gene expression Lgalsl 0.14 0.05 6.7e-11 0.13 0.14 0.12 0.13 8.1e-11 1.9e-11 6.5e-10 1.3e-10
12 BLA gene expression Lgalsl 0.16 0.07 4.6e-08 0.07 0.14 0.13 0.1 2.0e-04 4.7e-08 2.7e-07 8.0e-06
13 PL gene expression Lgalsl 0.15 0.06 1.5e-12 0.1 0.12 0.11 0.11 2.8e-11 6.1e-13 4.2e-12 3.2e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.2-0.00.2-0.2-0.4-0.40.30.40.20.4-0.40.40.40.4
Area under the delay curve1.11.75.2-2.3-1.2-2.10.00.31.40.91.61.1-1.00.70.91.2
BMI with tail0.10.31.4-1.2-0.5-1.10.60.70.20.0-0.10.10.1-0.4-0.3-0.4
BMI without tail0.00.20.7-0.8-0.4-0.80.10.10.5-0.30.40.5-0.4-0.10.1-0.2
Body weight0.52.27.7-2.7-2.7-2.80.80.71.1-0.51.60.3-0.1-0.10.51.1
Weight adjusted by age0.51.43.31.61.11.8-0.1-0.1-1.3-0.2-1.8-1.21.1-0.8-1.1-1.5
Bone surface0.40.81.7-1.2-0.9-0.81.21.3-0.5-1.0-0.1-0.50.7-1.0-0.7-0.4
Bone volume0.40.81.6-1.2-0.9-0.91.21.2-0.4-1.30.0-0.50.6-1.0-0.7-0.4
Breakpoint value in progressive ratio session0.50.83.3-1.8-1.4-1.40.50.61.1-0.41.00.6-0.4-0.20.3-0.2
Number of licking bursts0.31.02.8-1.3-1.4-1.7-0.2-0.21.10.31.40.6-0.50.60.91.3
Context. condit. distance diff. score0.70.92.10.21.40.3-1.0-0.71.00.90.51.5-1.40.90.8-0.4
Locomotion velocity, session 11.61.84.5-1.9-2.1-1.31.91.8-0.6-0.80.1-1.11.3-1.3-1.10.2
Locomotion distance, session 10.70.93.3-0.1-1.4-0.10.90.5-0.8-0.2-0.4-1.81.7-0.7-0.80.9
Locomotion velocity, session 21.01.24.01.0-0.90.90.80.2-1.60.2-1.0-2.01.8-0.4-0.71.2
Locomotion distance, session 22.53.59.51.0-0.81.31.61.1-2.3-1.7-1.8-3.13.0-1.9-2.1-0.4
Locomotion velocity, session 31.61.86.6-0.5-2.6-0.31.51.0-1.2-0.50.0-2.01.9-0.6-0.51.8
Locomotion distance, session 31.21.33.8-0.2-1.9-0.11.30.8-1.1-0.5-0.0-2.01.9-0.6-0.51.4
Stereotopy head waving bouts, day 30.20.30.50.2-0.00.30.60.5-0.7-0.4-0.7-0.60.6-0.6-0.7-0.4
Stereotopy head waving duration, day 30.20.20.80.70.90.6-0.5-0.4-0.00.3-0.50.2-0.20.1-0.1-0.4
Locomotion velocity, session 70.10.10.30.20.50.2-0.3-0.40.3-0.30.40.5-0.50.20.3-0.1
Locomotion distance, session 70.40.50.90.40.50.80.40.3-0.8-1.0-0.6-0.60.6-0.8-0.8-0.8
Stereotopy head waving bouts, day 70.80.91.90.70.1-0.1-1.2-1.40.91.30.60.6-0.81.31.11.4
Stereotopy head waving duration, day 70.50.62.1-0.1-0.7-0.8-0.6-0.80.81.00.70.3-0.40.90.81.5
Locomotion velocity, session 80.60.71.5-0.8-1.2-0.41.21.0-0.4-1.1-0.2-0.80.8-1.0-0.9-0.4
Locomotion distance, session 80.20.31.30.4-0.30.60.40.1-0.6-0.4-0.5-1.11.1-0.5-0.60.1
Degree of sensitization distance1.31.46.60.72.31.2-0.20.2-0.3-0.9-1.10.7-0.6-0.8-1.0-2.6
Degree of sensitization stereotypy1.82.04.70.1-0.5-0.9-1.4-1.61.51.71.40.9-1.11.81.72.2
Conditioned locomotion1.72.04.61.40.41.81.00.8-2.1-0.8-2.1-1.71.6-1.2-1.5-0.9
Cocaine response after cond. corrected2.53.77.5-1.7-1.5-0.62.72.7-1.6-2.0-1.0-1.82.0-2.5-2.2-1.2
Cocaine response after cond. not corrected1.52.14.4-1.9-1.6-1.02.12.1-0.9-1.6-0.3-1.11.3-1.7-1.4-0.7
Cocaine response before conditioning1.92.33.4-0.4-0.2-1.0-1.6-1.61.81.51.71.7-1.81.81.81.4
Saline control response0.50.61.7-0.60.20.51.01.3-1.00.6-0.8-0.91.0-0.6-0.8-0.1
Bone: connectivity density0.81.22.81.11.60.7-1.5-1.40.41.7-0.20.9-1.01.30.90.5
Bone: cortical apparent density0.30.41.41.00.81.2-0.2-0.3-0.70.9-0.4-0.50.40.40.10.7
Bone: cortical area2.03.212.2-3.5-2.8-3.11.31.41.3-0.72.10.8-0.5-0.20.70.8
Bone: cortical porosity0.40.41.6-0.9-1.3-0.90.80.6-0.1-0.90.4-0.30.3-0.5-0.10.3
Bone: cortical porosity0.50.51.5-1.2-1.2-1.10.80.70.1-0.90.6-0.10.2-0.5-0.10.2
Bone: cortical thickness1.32.16.5-2.6-2.4-2.50.70.71.10.11.80.6-0.50.40.91.5
Bone: cortical thickness0.30.41.6-1.3-0.8-0.80.91.1-0.2-0.10.2-0.10.2-0.4-0.30.0
Bone: cortical tissue density0.30.61.91.20.91.4-0.2-0.2-0.90.8-0.6-0.60.50.3-0.00.6
Condit. Reinf. active minus inactive responses1.51.73.71.11.30.3-1.9-1.81.21.90.31.3-1.31.61.30.4
Condit. Reinf. active-inactive response ratio0.90.92.10.81.10.2-1.5-1.30.91.40.01.0-1.01.10.8-0.0
Condit. Reinf. active responses0.40.51.10.20.6-0.1-1.0-0.80.91.00.40.8-0.80.90.80.2
Condit. Reinf. inactive responses0.20.31.0-1.0-0.8-0.60.70.80.0-0.70.5-0.10.2-0.5-0.30.0
Incentive salience index mean0.60.81.6-1.0-0.5-1.1-0.5-0.21.11.30.81.0-0.90.80.90.6
Condit. Reinf. lever presses1.42.29.4-3.1-2.5-2.41.31.60.60.01.20.3-0.0-0.30.10.7
Condit. Reinf. active minus inactive responses0.10.10.4-0.4-0.6-0.30.20.10.3-0.30.1-0.20.2-0.4-0.3-0.3
Condit. Reinf. active-inactive response ratio0.20.31.30.80.20.2-0.9-1.10.70.30.10.3-0.40.50.4-0.0
Condit. Reinf. active responses0.10.20.9-0.9-0.9-0.70.30.30.30.00.3-0.10.2-0.3-0.20.1
Condit. Reinf. inactive responses0.60.92.9-1.7-1.0-0.71.31.5-0.6-0.40.1-0.70.8-0.8-0.70.1
Condit. Reinf. lever presses0.50.71.9-0.2-0.7-0.5-0.7-0.80.91.40.80.4-0.41.11.01.3
Condit. Reinf. lever reinforcers received0.00.10.2-0.4-0.5-0.2-0.0-0.00.30.20.1-0.00.1-0.1-0.1-0.0
Conditioned reinforcement - actives0.41.85.0-0.3-1.1-0.21.71.5-1.4-2.2-0.5-1.51.5-1.6-1.3-0.7
Conditioned reinforcement - inactives0.51.34.2-1.6-2.0-1.11.41.2-0.3-1.30.8-0.91.0-0.7-0.00.7
Conditioned locomotion1.11.63.90.1-0.90.31.61.3-1.5-2.0-0.6-1.71.7-1.4-1.1-0.5
Patch foraging indifference point 0 sec0.00.10.4-0.5-0.2-0.4-0.3-0.20.7-0.10.50.4-0.40.10.3-0.2
Patch foraging indifference point AUC0.51.13.8-1.2-0.5-0.31.61.9-1.0-0.8-0.4-0.70.9-1.3-1.2-0.7
Delay disc. indifference point, 0s delay2.42.88.1-2.6-1.6-2.9-0.20.02.01.02.01.6-1.31.01.41.4
Delay disc. indifference point, 16s delay0.10.10.5-0.00.10.0-0.3-0.30.20.70.20.1-0.20.40.20.6
Delay disc. indifference point, 2s delay1.92.29.2-3.0-1.6-2.60.61.01.40.81.61.1-0.80.40.70.8
Delay disc. indifference point, 24s delay0.20.40.8-0.60.1-0.6-0.5-0.40.90.50.70.9-0.80.60.70.2
Delay disc. indifference point, 4s delay0.50.51.2-1.1-0.3-1.1-0.4-0.11.00.90.70.9-0.80.50.60.3
Delay disc. indifference point, 8s delay0.61.05.1-2.3-0.8-1.80.70.90.60.31.00.6-0.40.0-0.00.8
Indifference point function ln k0.00.10.4-0.1-0.6-0.3-0.2-0.40.4-0.20.40.1-0.10.10.30.2
Indifference point function log k0.00.10.4-0.1-0.6-0.3-0.2-0.40.4-0.20.40.1-0.10.10.30.2
Patch foraging total patch changes 0 sec0.00.10.3-0.30.0-0.2-0.2-0.20.5-0.20.30.4-0.3-0.00.1-0.5
Patch foraging total patch changes 12 sec0.50.71.4-0.2-0.00.40.80.9-0.8-1.2-0.7-0.70.7-1.2-1.0-1.2
Patch foraging total patch changes 18 sec0.20.52.30.21.50.3-0.5-0.20.40.3-0.11.2-1.10.30.1-1.0
Patch foraging total patch changes 24 sec0.00.20.5-0.50.1-0.5-0.20.10.50.40.40.7-0.60.20.2-0.1
Patch foraging total patch changes 6 sec0.30.51.7-1.3-0.0-0.50.71.1-0.1-0.50.00.20.0-0.7-0.5-1.1
Patch foraging time to switch 0 sec0.83.07.11.01.0-0.2-2.5-2.71.81.51.31.5-1.72.22.11.4
Patch foraging water rate 0 sec0.20.92.8-1.5-0.9-0.61.51.7-0.3-0.9-0.1-0.10.3-1.0-0.8-0.9
Patch foraging water rate 12 sec0.10.31.3-1.0-0.2-0.30.81.1-0.2-0.2-0.10.2-0.1-0.5-0.4-0.7
Patch foraging water rate 18 sec1.12.45.3-0.9-0.80.22.12.3-1.7-1.7-1.1-1.41.6-2.0-1.7-1.4
Patch foraging water rate 24 sec1.42.13.1-0.1-0.30.91.71.7-1.7-1.7-1.3-1.51.6-1.8-1.6-1.4
Patch foraging water rate 6 sec0.60.93.5-1.9-1.1-1.11.31.60.1-0.50.40.3-0.1-0.7-0.4-0.4
Seeking ratio, delayed vs. immediate footshock0.20.30.70.50.50.70.80.9-0.7-0.6-0.4-0.40.4-0.5-0.6-0.5
Distance traveled before self-admin0.40.82.1-1.5-1.3-0.81.10.9-0.2-1.20.2-0.40.5-1.0-0.6-0.3
Distance traveled after self-admin0.10.10.5-0.4-0.2-0.00.00.00.4-0.1-0.10.4-0.4-0.10.0-0.7
Extensor digitorum longus weight0.52.19.7-3.1-0.9-2.21.01.70.90.91.41.7-1.40.20.50.4
Bone: elastic displacement0.50.72.4-1.1-1.5-1.20.90.7-0.10.00.7-0.40.4-0.00.11.3
Bone: elastic work1.72.27.1-2.7-2.6-2.41.61.50.3-0.81.5-0.10.3-0.40.31.1
Bone: endosteal estimation1.33.19.4-3.1-2.7-2.42.02.10.2-2.31.0-0.30.6-1.6-0.6-0.7
Bone: endosteal perimeter0.51.35.2-2.3-1.5-2.00.91.10.8-1.11.10.5-0.2-0.60.1-0.5
Epididymis fat weight1.05.016.6-3.3-3.6-4.10.3-0.02.3-0.53.20.7-0.50.61.42.5
Delta time in closed arm before/after self-admin0.10.10.30.20.10.2-0.5-0.40.30.5-0.00.2-0.20.10.1-0.4
Delta time in open arm before/after self-admin0.10.10.20.30.20.2-0.3-0.30.3-0.00.10.4-0.50.20.4-0.3
Diff in mean of infusions in LGA sessions1.01.95.0-1.1-0.4-1.3-0.9-0.72.20.41.62.1-2.01.21.50.0
Delay discount exponential model param1.31.85.62.41.22.20.0-0.2-1.5-0.9-1.7-1.21.1-0.8-1.0-1.2
Extinction: sum of active levers before priming0.10.21.30.20.50.40.20.4-0.1-0.3-0.4-0.10.2-0.6-0.6-1.1
Active lever presses in extinction session 61.11.13.1-1.2-0.6-0.81.51.8-0.5-0.8-0.6-0.40.6-1.2-1.2-1.2
Bone: final force1.32.09.2-2.2-3.0-2.11.10.80.6-1.41.6-0.10.2-0.30.61.0
Bone: final moment1.42.29.9-2.3-3.1-2.21.30.90.5-1.51.6-0.20.3-0.40.51.0
Food consumed during 24 hour testing period0.91.85.3-2.3-2.3-1.71.71.6-0.1-1.31.2-0.40.5-0.7-0.10.7
Glucose0.30.41.60.71.20.9-0.2-0.1-0.3-0.5-0.7-0.10.1-0.4-0.4-1.3
Heart weight0.10.20.8-0.60.2-0.20.10.40.3-0.50.00.5-0.4-0.4-0.2-0.9
Delay discount hyperbolic model param1.62.06.12.51.32.30.1-0.2-1.6-1.1-1.8-1.31.1-0.8-1.1-1.3
Intermittent access intake day 1-15 change0.21.03.2-1.1-1.7-1.60.3-0.00.20.11.2-0.60.60.30.51.8
Intermittent access intake escalation0.21.03.7-1.1-1.6-1.50.3-0.00.30.41.2-0.60.60.40.61.9
Intermittent access intake escalation 20.50.93.2-0.7-1.2-1.4-0.3-0.60.70.71.2-0.20.20.81.01.8
Intermitt. access day 1 inactive lever presses0.00.61.6-0.9-1.00.00.90.8-0.3-1.20.2-1.01.1-0.9-0.3-0.6
Intermitt. access day 15 inactive lever presses0.31.53.50.20.1-0.6-1.8-1.91.71.11.21.1-1.11.41.60.9
Intermitt. access escalation Index0.61.85.32.32.32.0-0.7-0.5-0.91.1-1.9-0.30.2-0.1-0.9-1.2
Intermittent access day 1 total infusions2.88.212.40.10.32.03.43.4-3.5-3.5-2.8-2.62.7-3.5-3.4-3.1
Intermittent access day 15 total infusions1.23.06.1-0.8-1.40.12.42.1-2.1-1.9-0.6-2.42.5-1.9-1.5-0.1
Intermittent access terminal intake (last 3 days)0.61.02.6-0.3-0.60.11.31.1-1.4-0.8-0.4-1.61.6-0.9-0.90.2
Intermittent access total infusions2.73.26.0-0.0-0.11.12.32.2-2.4-2.2-1.4-2.02.0-2.1-2.0-1.2
Intermittent access day 1 locomotion2.74.98.60.4-0.11.72.62.4-2.9-2.7-2.1-2.32.3-2.6-2.5-1.9
Intermittent access day 15 total locomotion0.83.26.7-0.7-1.70.22.52.0-2.0-2.6-0.7-2.32.3-2.0-1.5-0.4
Intermittent access total locomotion3.23.87.10.4-0.31.42.32.0-2.7-2.6-1.7-2.22.2-2.2-2.0-1.3
Intermittent access standard deviation0.21.03.2-0.3-0.7-0.11.00.7-1.3-1.1-0.2-1.81.8-1.0-0.80.4
Left kidney weight0.43.612.9-3.2-3.6-3.21.21.00.9-0.32.2-0.10.3-0.00.72.2
Right kidney weight0.64.116.7-3.5-4.1-2.91.91.70.3-1.41.8-0.70.9-0.80.11.4
Cocaine induced anxiety0.10.41.51.00.31.2-0.1-0.2-0.70.3-0.7-0.70.6-0.0-0.1-0.1
Post-drug Anxiety0.91.02.50.3-0.6-0.1-1.1-1.20.81.60.70.3-0.41.31.31.5
Baseline Anxiety1.32.24.1-0.5-0.6-1.4-1.5-1.52.01.61.61.3-1.31.71.71.7
Tail length0.42.45.7-1.9-2.4-2.3-0.1-0.41.5-0.02.30.9-0.90.91.51.9
Length with tail0.83.510.5-2.8-3.2-3.10.2-0.01.7-0.32.70.7-0.60.71.42.1
Length without tail0.31.45.0-2.2-2.1-2.20.70.80.8-0.41.10.10.1-0.30.20.5
Times rat made contact with spout1.61.84.8-2.0-1.9-2.20.40.31.10.32.00.6-0.50.71.11.9
Lifetime Intake2.53.26.6-0.7-0.60.52.62.4-2.2-2.3-1.0-1.91.9-2.1-1.8-1.0
Liver weight, left1.22.13.6-1.5-1.4-1.9-0.8-0.81.81.51.71.2-1.21.41.61.7
Liver weight, right1.01.84.6-2.1-1.9-1.41.81.7-0.4-1.40.4-1.11.3-1.4-0.9-0.2
Locomotor activity0.71.12.1-0.7-1.10.11.31.4-1.1-0.9-0.7-1.31.4-1.3-1.0-0.5
Locomotor testing distance0.81.94.3-0.10.10.81.21.4-1.3-1.6-1.6-1.21.3-1.9-1.8-2.1
Locomotor testing rearing0.20.62.7-1.6-1.2-1.10.50.70.5-0.60.60.3-0.1-0.30.2-0.4
Locomotion in novel chamber2.02.76.41.21.31.70.91.2-2.1-0.2-2.5-1.61.6-1.6-2.2-1.8
Locomotion in novel chamber post-restriction0.10.41.0-0.9-1.0-0.70.80.9-0.20.2-0.0-0.70.8-0.5-0.40.3
Fecal boli incidents, locomotor time 10.20.42.2-1.5-0.6-0.80.20.40.7-0.10.80.6-0.50.00.5-0.2
Change in fecal boli incidents, locomotor task1.01.13.0-1.2-1.7-1.21.31.0-0.3-1.50.6-0.80.9-1.0-0.70.5
Time >=10cm from walls, locomotor time 10.00.00.10.0-0.3-0.1-0.3-0.20.00.3-0.0-0.30.30.10.20.1
Bouts of movement, locomotor time 10.30.41.0-0.4-0.5-0.7-0.6-0.71.00.00.80.7-0.70.60.90.2
Total resting periods, locomotor time 10.60.71.4-0.6-0.7-0.8-0.7-0.71.2-0.11.01.0-1.00.71.10.2
Rest time, locomotor task time 10.40.71.6-1.2-1.1-1.3-0.1-0.21.1-0.41.00.9-0.80.30.8-0.0
Distance moved, locomotor task time 10.51.45.12.31.81.8-0.8-0.8-0.91.2-1.3-0.70.50.3-0.50.1
Vertical activity count, locomotor time 10.11.02.71.61.51.6-0.1-0.0-1.10.6-1.4-0.80.7-0.3-0.7-0.6
Time >=10cm from walls, locomotor time 20.30.91.81.20.61.30.10.0-1.1-0.2-1.4-1.31.3-0.7-0.9-0.7
Bouts of movement, locomotor time 20.20.61.80.7-0.30.50.30.0-1.0-1.0-0.8-1.31.2-0.7-0.6-0.3
Total resting periods, locomotor time 20.10.30.90.8-0.40.3-0.1-0.5-0.6-0.7-0.4-0.90.8-0.2-0.10.1
Rest time, locomotor task time 20.81.33.1-1.3-1.3-1.8-0.2-0.41.5-0.31.71.3-1.20.61.00.6
Distance moved, locomotor task time 20.91.33.61.91.61.8-0.2-0.3-1.40.5-1.5-1.10.9-0.2-0.8-0.1
Vertical activity count, locomotor time 20.92.14.51.61.41.80.50.6-1.8-0.2-2.1-1.61.5-1.1-1.6-1.2
Light reinforcement 10.10.31.3-0.20.20.00.20.5-0.3-0.2-0.8-0.10.2-0.7-0.8-1.2
Light reinforcement 20.30.81.8-0.40.0-0.7-1.0-0.80.91.30.80.9-0.91.01.00.9
Bone: marrow area1.23.08.9-3.0-2.6-2.32.02.10.2-2.31.0-0.30.6-1.5-0.6-0.6
Bone: maximum diameter1.53.010.3-3.2-2.4-2.62.02.10.4-2.01.10.10.2-1.3-0.5-0.5
Bone: maximum force0.91.86.9-2.3-2.6-2.11.21.00.5-1.31.3-0.00.2-0.50.30.5
Bone: maximum moment1.12.17.6-2.5-2.8-2.21.41.20.5-1.51.3-0.10.3-0.70.10.4
Mean time between licks in bursts0.31.74.9-0.5-0.7-1.1-0.9-1.01.21.71.60.7-0.81.51.62.2
Mean num. licks in bursts0.10.20.50.60.50.70.40.4-0.7-0.3-0.5-0.50.5-0.3-0.5-0.3
Cd content in liver2.32.67.01.52.61.2-2.0-1.71.40.4-0.12.1-2.11.00.8-1.9
Co content in liver0.30.41.00.70.10.3-0.7-1.00.4-0.20.70.2-0.30.80.90.7
Cu content in liver0.20.20.9-0.3-0.9-0.50.20.1-0.10.40.2-0.60.60.10.21.0
Fe content in liver0.50.71.80.70.20.80.60.4-1.1-0.1-1.1-1.31.2-0.6-0.9-0.0
K content in liver2.01.95.5-2.4-2.2-1.81.81.8-0.5-0.10.6-0.91.1-0.7-0.41.2
Mg content in liver0.91.02.3-0.6-1.2-0.41.20.9-0.9-0.8-0.3-1.51.5-1.0-0.80.4
Mn content in liver1.61.86.0-1.6-2.5-1.31.71.4-0.7-0.80.6-1.41.5-0.7-0.31.5
Na content in liver1.01.12.4-0.6-0.80.11.61.5-1.3-0.7-0.7-1.31.4-1.1-1.00.1
Rb content in liver1.01.14.12.01.71.7-1.0-1.0-0.61.1-0.9-0.20.00.80.30.1
Se content in liver2.32.78.7-2.2-2.9-2.21.91.5-0.4-1.00.7-1.61.7-0.9-0.51.5
Sr content in liver0.30.20.5-0.3-0.30.00.70.7-0.4-0.7-0.4-0.20.3-0.6-0.5-0.6
Zn content in liver0.40.51.20.10.3-0.4-0.9-1.10.90.10.70.7-0.70.70.90.3
Bone: minimum diameter1.53.09.7-3.1-2.3-3.10.70.81.8-1.22.11.4-1.1-0.10.80.1
Time in familiar zone, hab. session 11.01.12.4-0.3-0.10.11.31.6-1.1-0.7-1.0-0.81.0-1.3-1.5-1.1
Time in novel zone, hab. session 10.50.61.61.01.30.8-1.1-1.20.4-0.00.00.6-0.70.60.6-0.4
Total zone transitions, hab. session 11.72.34.9-0.8-1.9-0.41.91.5-1.4-1.6-0.5-2.22.2-1.7-1.50.3
Total locomotion distance, hab. session 10.50.82.2-0.5-1.5-0.61.00.6-0.5-0.9-0.0-1.21.2-0.8-0.70.6
Locomotion velocity, hab. session 10.71.04.2-1.0-2.1-1.21.00.6-0.2-0.50.4-1.11.1-0.5-0.41.1
Time in familiar zone, hab. session 20.70.82.51.41.31.6-0.4-0.3-0.81.2-1.2-0.50.40.2-0.3-0.1
Time in novel zone, hab. session 20.40.41.6-0.7-0.7-1.00.20.10.7-1.30.90.4-0.3-0.30.1-0.2
Total zone transitions, hab. session 20.91.13.8-0.1-1.30.11.10.7-1.1-0.6-0.3-2.01.9-0.8-0.70.9
Total locomotion distance, hab. session 20.20.31.00.7-0.60.2-0.1-0.5-0.3-0.20.1-1.00.90.00.01.0
Locomotion velocity, hab. session 20.30.41.80.5-0.70.30.4-0.1-0.6-0.6-0.1-1.31.2-0.4-0.40.7
Novel to familiar place preference ratio0.70.91.90.21.00.1-1.2-1.01.10.50.81.4-1.40.90.9-0.1
Novelty place preference0.50.71.50.21.00.2-1.0-0.80.90.40.71.2-1.20.70.8-0.2
Time in novel zone, NPP test0.70.91.90.31.10.1-1.3-1.01.10.50.71.4-1.40.90.9-0.1
Total zone transitions, NPP test0.81.15.3-1.1-2.3-1.60.50.00.4-0.11.1-0.70.70.10.31.8
Total locomotion distance, NPP test0.50.72.50.5-1.0-0.6-0.7-1.30.80.30.9-0.20.00.80.81.6
Locomotion velocity, NPP test0.30.41.60.3-1.3-0.4-0.1-0.70.3-0.40.6-0.70.50.20.31.2
Intraocular pressure0.60.91.90.40.20.1-1.3-1.41.11.10.70.9-1.01.21.30.8
Delta distance traveled before/after self-admin0.50.61.20.70.60.3-1.1-1.00.90.80.20.9-0.90.90.9-0.1
Delta ambulatory time before/after self-admin0.30.61.91.21.41.1-0.6-0.4-0.1-0.0-0.80.3-0.30.0-0.2-1.3
Parametrial fat weight0.71.74.11.1-0.71.11.00.4-1.6-1.8-1.1-2.01.9-1.3-1.2-0.4
Pavlov. Cond. lever latency2.33.06.82.51.82.60.50.2-1.9-1.4-2.2-1.31.1-1.3-1.8-1.8
Pavlov. Cond. magazine entry latency0.60.72.6-1.6-1.4-1.60.60.60.5-0.70.8-0.10.2-0.40.10.1
Pavlov. Cond. change in total contacts3.63.87.0-1.9-1.6-2.5-1.3-1.22.51.62.61.5-1.41.92.42.2
Pavlov. Cond. index score1.41.86.3-2.5-2.0-2.50.30.41.20.31.70.5-0.30.30.91.0
Pavlov. Cond. latency score1.82.37.3-2.6-2.1-2.70.00.21.60.61.90.8-0.60.71.21.4
Pavlov. Cond. lever contacts1.61.94.8-2.2-1.6-2.2-0.3-0.01.51.01.80.9-0.70.91.41.4
Pavlov. Cond. magazine entry number0.60.72.51.61.31.5-0.5-0.5-0.50.7-1.00.1-0.30.3-0.3-0.2
Pavlov. Cond. intertrial magazine entries0.50.61.91.01.41.1-0.4-0.1-0.30.8-1.00.1-0.1-0.1-0.5-0.9
Pavlov. Cond. lever-magazine prob. diff.1.82.27.3-2.7-2.2-2.70.30.41.40.41.80.6-0.40.41.11.2
Pavlov. Cond. response bias1.11.44.7-2.2-1.8-2.10.20.31.10.11.60.4-0.20.30.90.8
Pavlov. Cond. lever latency0.20.20.8-0.60.3-0.40.40.6-0.1-0.6-0.30.3-0.2-0.5-0.4-0.9
Pavlov. Cond. magazine entry latency0.81.12.71.60.81.1-1.4-1.60.41.10.30.3-0.51.21.10.9
Pavlov. Cond. change in total contacts0.20.41.41.20.41.2-0.2-0.3-0.40.3-0.6-0.80.7-0.1-0.3-0.0
Pavlov. Cond. index score0.40.61.71.30.11.0-0.8-1.10.00.90.1-0.40.20.80.71.0
Pavlov. Cond. latency score0.30.51.81.30.11.0-0.7-1.0-0.10.8-0.0-0.50.30.70.61.0
Pavlov. Cond. lever contacts0.10.10.40.6-0.20.6-0.2-0.4-0.10.40.0-0.40.30.30.20.5
Pavlov. Cond. magazine entry number0.70.92.8-1.7-0.9-1.41.21.3-0.1-1.10.10.10.1-0.9-0.7-0.6
Pavlov. Cond. intertrial magazine entries0.51.01.7-0.9-0.9-0.71.21.3-0.6-1.2-0.7-0.60.7-1.3-1.2-1.1
Pavlov. Cond. lever-magazine prob. diff.0.40.51.51.2-0.00.9-0.7-1.0-0.10.90.1-0.50.40.70.61.1
Pavlov. Cond. response bias0.30.41.31.10.41.1-0.6-0.7-0.10.7-0.1-0.30.20.50.40.5
Time in closed arm before self-admin0.10.20.40.60.30.2-0.0-0.1-0.60.4-0.4-0.50.40.0-0.30.5
Time in closed arm after self-admin1.01.12.51.21.20.2-1.6-1.60.71.40.30.8-1.01.10.70.6
Time in open arm before self-admin0.40.52.70.20.60.40.50.7-0.4-0.8-0.8-0.10.3-0.8-0.9-1.6
Time in open arm after self-admin0.30.31.80.30.70.70.00.3-0.2-0.1-0.80.2-0.1-0.3-0.4-1.3
Bone: periosteal estimation1.94.616.3-4.0-3.4-3.42.22.20.8-2.11.90.20.2-1.2-0.10.0
Bone: periosteal perimeter1.22.38.6-2.9-2.3-2.71.31.41.0-1.21.60.4-0.1-0.60.20.2
Bone: post-yield work0.30.63.8-0.00.70.20.10.3-0.1-0.9-0.8-0.10.2-1.0-0.9-1.9
Progressive ratio test 1 active lever presses3.66.310.80.40.72.02.62.7-3.3-2.3-2.9-2.52.6-3.0-3.2-2.6
Progressive ratio test 1 breakpoint3.56.110.30.40.72.02.62.7-3.2-2.3-2.8-2.52.5-2.9-3.1-2.5
Progressive ratio test 1 inactive lever presses0.30.91.6-0.10.10.61.01.0-1.1-1.2-0.6-1.01.0-1.2-1.0-1.0
Progressive ratio test 2 active lever presses1.82.54.3-0.2-0.50.72.12.0-2.0-1.9-1.1-1.91.9-1.9-1.6-1.0
Progressive ratio test 2 breakpoint1.72.23.8-0.2-0.40.72.01.9-1.9-1.8-1.0-1.71.8-1.7-1.5-1.0
Progressive ratio test 2 inactive lever presses0.41.33.0-1.0-1.1-0.21.71.6-0.9-1.7-0.1-1.01.1-1.3-0.8-0.6
Incentive Sensitization - Responses0.00.00.10.30.20.20.30.3-0.3-0.3-0.2-0.10.1-0.1-0.0-0.2
Incentive Sensitization - Breakpoint0.00.00.20.40.40.20.10.0-0.2-0.2-0.1-0.10.00.10.1-0.1
Sum of active levers in priming session hrs 5-60.90.81.8-0.2-0.70.51.31.1-0.8-1.3-0.5-1.11.1-1.1-0.7-0.8
Progressive ratio0.10.31.0-0.40.30.10.40.5-0.2-0.7-0.3-0.40.5-0.8-0.6-1.0
Food seeking constrained by brief footshock0.91.11.8-0.20.10.81.21.3-1.2-1.2-1.0-0.80.9-1.3-1.3-1.3
Seeking ratio, punishment vs. effort0.10.20.50.0-0.10.30.60.6-0.7-0.4-0.5-0.20.2-0.4-0.6-0.3
Retroperitoneal fat weight0.10.41.5-0.4-1.2-0.70.1-0.50.3-0.90.7-0.50.4-0.20.10.7
Reaction time number correct0.20.62.0-0.8-0.80.31.31.4-0.7-0.3-0.4-0.60.7-0.7-0.5-0.4
Reaction time mean minus median0.10.40.8-0.10.2-0.0-0.8-0.60.60.90.50.8-0.80.80.70.4
Reaction time mean minus median AUC0.10.41.11.00.50.9-0.8-0.90.10.7-0.10.1-0.20.70.60.5
Reaction time num false alarms0.81.33.7-1.8-1.0-1.9-0.10.21.41.01.21.3-1.10.70.70.9
Reaction time num false alarms AUC0.40.92.3-1.4-0.7-1.5-0.20.11.20.91.01.2-1.00.60.60.8
Reaction time trials correct on left0.20.62.0-0.8-0.80.31.31.4-0.7-0.3-0.4-0.60.7-0.7-0.5-0.4
Reaction time trials on left0.20.62.1-0.8-0.80.31.31.4-0.7-0.3-0.4-0.60.7-0.8-0.5-0.5
Reaction time mean0.30.73.10.50.91.00.10.3-0.5-0.9-1.0-0.10.1-0.8-0.8-1.8
Reaction time mean AUC0.41.03.80.70.91.30.40.5-0.9-1.1-1.4-0.40.5-1.0-1.1-1.9
Median of all reaction times0.81.34.60.60.91.20.50.6-0.9-1.3-1.5-0.50.5-1.2-1.2-2.1
Reaction time omissions0.10.20.5-0.3-0.20.40.70.7-0.3-0.5-0.2-0.40.5-0.6-0.4-0.3
Reaction time false alarm rate0.81.13.2-1.1-0.6-1.8-0.6-0.41.40.71.21.1-1.10.80.71.0
Reaction time premature initiation rate1.42.13.90.80.6-0.2-2.0-1.91.32.01.21.1-1.31.91.71.7
Reaction time premature initiations0.10.41.50.40.20.3-0.8-0.60.41.20.40.4-0.50.90.80.9
Std. dev. reaction times0.10.41.50.61.20.9-0.7-0.40.20.4-0.30.7-0.70.30.1-0.8
Reaction time trials completed0.20.62.1-0.8-0.80.31.31.4-0.7-0.3-0.4-0.60.7-0.8-0.5-0.5
Reaction time trials AUC0.20.72.4-0.9-0.80.31.31.6-0.7-0.3-0.5-0.50.7-0.8-0.6-0.6
Run reversals in cocaine runway, females0.91.03.60.90.71.90.60.7-1.50.1-1.3-1.21.1-0.6-0.7-0.6
Run reversals in cocaine runway, males0.50.61.71.30.21.0-0.0-0.3-1.0-0.0-0.9-1.21.1-0.2-0.40.4
Latency to leave start box in cocaine runway3.34.57.40.10.1-1.0-2.7-2.72.62.32.02.1-2.22.62.71.9
Latency to leave start box in cocaine runway, F3.34.16.6-0.4-0.4-1.3-2.2-2.12.42.52.02.0-2.12.52.62.2
Latency to leave start box in cocaine runway, M1.11.03.00.80.50.1-1.6-1.71.10.60.70.8-0.91.21.30.5
Std. dev. time between licks in bursts1.01.96.5-2.0-2.6-1.90.80.50.8-0.02.00.00.00.30.82.1
Total sessions with >9 infusions2.83.57.7-0.8-0.90.12.82.5-2.2-2.7-0.9-1.81.9-2.2-2.0-0.8
Short access day 1 total inactive lever presses0.71.54.1-1.6-2.0-0.91.61.3-0.5-2.00.4-0.90.9-1.1-0.5-0.1
Short access day 10 total inactive lever presses0.00.30.8-0.30.30.5-0.6-0.40.80.10.50.7-0.70.40.9-0.6
Short access day 1 total infusions1.01.95.0-1.6-1.5-0.62.22.1-1.1-2.00.1-1.11.2-1.5-0.9-0.1
Short access day 10 total infusions2.33.87.30.50.51.62.22.2-2.7-2.1-1.9-2.02.0-2.2-2.3-1.7
Short access total infusions1.21.84.0-0.5-0.60.22.01.9-1.6-1.9-0.6-1.21.3-1.6-1.3-0.7
Short access day 1 locomotion1.11.85.1-1.3-1.4-0.62.11.8-1.1-2.20.1-1.01.1-1.5-1.1-0.2
Short access day 10 total locomotion1.97.815.3-1.1-2.20.33.93.5-3.2-3.8-1.5-3.23.3-3.4-2.9-1.2
Short access total locomotion2.94.49.2-0.6-1.10.53.02.7-2.6-2.9-1.2-2.22.2-2.5-2.2-0.9
One hour access (0.3 mA shock)1.92.24.1-0.2-1.2-0.41.91.4-1.7-2.0-0.8-1.91.9-1.8-1.7-0.4
Compulsive drug intake1.52.24.80.70.5-0.8-2.0-1.91.62.20.91.5-1.61.81.41.1
One hour access (shock baseline)1.33.35.9-0.7-1.10.22.42.1-2.1-2.4-1.0-2.32.4-2.2-1.9-0.7
Social response proportion0.20.21.10.60.31.10.10.0-0.4-0.7-0.4-0.0-0.1-0.2-0.1-0.7
Social responses0.81.02.3-0.8-1.1-0.11.31.2-0.7-1.5-0.5-0.91.0-1.3-1.0-0.9
Social time0.71.23.30.30.80.2-1.2-1.11.20.20.61.8-1.81.11.3-0.4
Soleus weight0.61.78.0-2.8-1.5-2.01.11.60.60.31.30.9-0.6-0.10.30.5
Bone: stiffness0.51.02.4-1.2-1.6-1.5-0.2-0.41.10.31.30.6-0.60.71.11.1
Tibialis anterior weight0.72.27.1-2.20.3-1.8-0.40.51.61.31.32.7-2.40.90.9-0.2
Time to tail flick, vehicle, before self-admin0.70.91.60.10.3-0.4-0.8-0.71.21.10.91.3-1.31.21.20.7
Time to tail flick, vehicle, after self-admin2.14.38.4-1.5-0.6-1.7-1.8-1.52.91.92.52.7-2.62.22.61.3
Time to tail flick, test, before self-admin1.31.53.50.30.4-0.7-1.2-1.11.11.91.11.1-1.21.81.51.6
Time to tail flick, test, after self-admin2.22.34.1-0.60.0-1.0-1.5-1.32.02.01.61.7-1.71.81.91.3
Delta time to tail flick, vehicle, before/after SA1.11.14.6-2.1-1.0-1.50.10.41.20.61.31.1-0.90.50.80.5
Delta time to tail flick, test, before/after SA0.10.10.7-0.80.00.00.10.40.3-0.10.10.3-0.2-0.3-0.2-0.6
Tibia length2.67.127.1-4.5-5.2-4.42.21.81.1-1.72.8-0.30.6-0.60.72.0
Ambulatory time before self-admin0.30.93.7-1.9-1.6-1.50.90.80.4-0.71.00.1-0.0-0.40.00.5
Ambulatory time after self-admin0.10.20.7-0.6-0.2-0.30.30.40.3-0.5-0.00.4-0.3-0.4-0.2-0.9
Bone: tissue strength0.60.72.0-1.3-1.4-1.40.40.20.6-1.01.00.1-0.0-0.20.30.4
Total heroin consumption0.60.72.0-1.2-0.7-0.70.90.90.2-1.40.0-0.10.2-1.0-0.6-1.2
Bone: trabecular number0.61.12.20.81.00.1-1.5-1.50.81.20.31.2-1.31.31.00.7
Bone: trabecular spacing0.00.00.1-0.20.20.10.20.30.00.00.0-0.10.2-0.2-0.2-0.3
Bone: trabecular thickness0.10.10.40.10.60.30.20.4-0.40.3-0.50.1-0.1-0.2-0.4-0.3
Bone: trabecular tissue density0.71.32.1-0.0-0.2-0.4-1.3-1.31.51.21.21.2-1.21.41.41.0
Water consumed over 24 hours0.71.34.3-1.9-2.1-1.61.00.80.4-1.01.6-0.10.2-0.10.41.1
Number of responses in last shaping day0.81.02.9-1.6-1.7-1.60.70.50.3-0.91.3-0.20.2-0.10.31.2