Hub : Genes

Leo1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA isoform ratio NM_001005548.1 0.07 0.05 2.0e-03 0.02 0.01 0.01 0 3.0e-02 5.4e-02 8.6e-02 1.6e-01
2 BLA isoform ratio XM_039081146.2 0.07 0.05 1.9e-03 0.03 0.02 0.01 0.01 8.8e-03 4.3e-02 7.2e-02 1.3e-01
3 BLA alternative polyA XM_039081146.2 0.09 0.05 1.1e-03 0.03 0.02 0.02 0.01 9.7e-03 4.3e-02 3.4e-02 1.0e-01
4 Adipose mRNA stability Leo1 0.06 0.04 2.8e-05 0.05 0.04 0.04 0.04 4.5e-06 3.2e-05 2.2e-05 1.5e-05
5 Adipose gene expression Leo1 0.03 0.02 1.5e-03 0 0.01 0.01 0 7.5e-02 2.0e-02 6.2e-02 1.6e-01
6 BLA alternative polyA NM_001005548.1 0.07 0.05 7.4e-03 -0 0.01 -0 -0 6.3e-01 1.4e-01 7.3e-01 4.2e-01
7 PL alternative polyA XM_039081146.2 0.04 0.02 2.9e-03 0.02 0.02 0.01 0.02 1.4e-03 2.5e-03 1.2e-02 4.9e-03
8 Brain mRNA stability Leo1 0.08 0.05 6.6e-06 0.04 0.06 0.05 0.04 6.5e-05 7.6e-06 1.2e-05 6.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.00.00.10.1-0.1-0.2-0.3-0.1-0.2-0.3-0.1
Area under the delay curve1.01.62.5-1.21.20.8-1.41.60.51.5-1.6
BMI with tail2.27.612.6-2.32.32.6-2.53.61.93.2-3.2
BMI without tail0.52.76.5-1.01.01.2-1.82.40.41.8-2.6
Body weight1.56.513.1-1.91.92.2-2.23.61.42.8-3.4
Weight adjusted by age0.82.32.9-1.71.71.5-1.71.61.60.7-1.4
Bone surface1.22.44.5-1.71.71.6-2.11.61.10.7-1.6
Bone volume0.61.22.4-1.11.11.0-1.61.20.60.6-1.3
Breakpoint value in progressive ratio session0.71.31.8-1.31.31.1-1.31.11.20.3-1.0
Number of licking bursts0.92.73.5-1.91.91.8-1.81.61.70.8-1.5
Context. condit. distance diff. score0.60.71.1-1.11.11.0-0.60.61.10.6-0.3
Locomotion velocity, session 10.60.71.6-0.40.40.5-0.81.1-0.11.3-1.2
Locomotion distance, session 10.40.50.90.9-0.9-0.9-0.2-0.4-1.0-0.9-0.2
Locomotion velocity, session 20.81.01.9-0.60.60.8-1.31.20.11.2-1.4
Locomotion distance, session 20.50.71.90.8-0.8-0.7-0.80.5-1.40.2-1.2
Locomotion velocity, session 30.10.10.9-0.10.10.2-0.9-0.1-0.30.0-0.2
Locomotion distance, session 31.51.72.81.5-1.5-1.50.5-1.5-1.7-0.90.9
Stereotopy head waving bouts, day 30.70.81.7-0.60.60.70.6-0.81.3-0.91.3
Stereotopy head waving duration, day 30.70.82.3-1.01.01.10.4-0.21.5-0.10.9
Locomotion velocity, session 70.10.10.20.2-0.2-0.20.0-0.3-0.2-0.40.2
Locomotion distance, session 70.10.10.3-0.10.10.1-0.60.3-0.1-0.0-0.5
Stereotopy head waving bouts, day 70.20.20.6-0.60.60.6-0.8-0.00.20.5-0.0
Stereotopy head waving duration, day 70.30.30.9-0.60.60.6-0.90.20.10.8-0.3
Locomotion velocity, session 80.70.92.0-0.40.40.6-1.40.8-0.41.4-1.2
Locomotion distance, session 80.40.62.0-0.40.40.5-1.40.8-0.10.5-1.2
Degree of sensitization distance1.21.32.0-1.31.31.3-0.71.31.40.6-0.9
Degree of sensitization stereotypy0.20.20.8-0.50.50.4-0.90.1-0.10.6-0.3
Conditioned locomotion0.40.51.00.8-0.8-0.70.8-0.4-0.3-1.00.4
Cocaine response after cond. corrected1.62.33.6-1.71.71.6-1.21.51.41.9-1.1
Cocaine response after cond. not corrected2.23.24.2-2.12.12.1-1.11.81.92.0-1.2
Cocaine response before conditioning1.11.32.0-1.21.21.4-0.71.41.20.8-1.2
Saline control response0.40.51.7-0.10.10.20.8-1.00.5-0.51.3
Bone: connectivity density0.71.12.21.0-1.0-1.20.3-1.2-1.0-1.50.7
Bone: cortical apparent density2.13.45.61.9-1.9-1.92.4-2.0-1.6-0.61.9
Bone: cortical area0.40.61.7-0.80.80.60.4-0.41.3-0.71.0
Bone: cortical porosity0.70.72.70.3-0.3-0.20.8-0.90.5-1.61.1
Bone: cortical porosity0.70.83.30.3-0.3-0.30.7-1.00.5-1.81.1
Bone: cortical thickness2.23.77.41.4-1.4-1.72.7-2.4-0.6-1.62.7
Bone: cortical thickness0.50.62.00.2-0.2-0.31.4-0.80.3-0.51.3
Bone: cortical tissue density2.03.15.01.9-1.9-1.92.2-1.8-1.7-0.51.7
Condit. Reinf. active minus inactive responses1.01.13.00.4-0.4-0.3-1.01.1-1.21.3-1.7
Condit. Reinf. active-inactive response ratio0.30.41.9-0.40.40.50.10.50.11.4-0.4
Condit. Reinf. active responses1.41.75.20.1-0.1-0.1-1.81.5-1.21.3-2.3
Condit. Reinf. inactive responses0.70.92.90.1-0.1-0.2-1.71.0-0.90.2-1.7
Incentive salience index mean1.11.43.7-0.70.70.7-1.81.60.20.5-1.9
Condit. Reinf. lever presses1.62.43.9-1.51.51.5-2.01.31.9-1.1-1.3
Condit. Reinf. active minus inactive responses1.21.86.3-1.21.21.2-1.21.20.22.5-1.1
Condit. Reinf. active-inactive response ratio0.30.51.8-0.80.80.8-0.20.10.31.40.1
Condit. Reinf. active responses1.92.76.5-1.21.21.4-1.61.90.32.6-2.0
Condit. Reinf. inactive responses0.91.43.7-0.70.70.7-1.31.70.30.9-1.9
Condit. Reinf. lever presses1.72.53.8-1.91.91.9-1.01.21.91.5-0.7
Condit. Reinf. lever reinforcers received1.62.36.4-1.11.11.2-1.41.80.32.5-1.8
Conditioned reinforcement - actives0.20.72.1-0.90.91.0-0.50.41.5-0.4-0.1
Conditioned reinforcement - inactives0.00.00.10.0-0.00.1-0.30.30.20.2-0.3
Conditioned locomotion0.20.30.90.5-0.5-0.61.0-0.4-0.1-0.70.6
Patch foraging indifference point 0 sec0.20.41.1-0.70.70.8-0.50.50.31.1-0.4
Patch foraging indifference point AUC0.40.91.71.3-1.3-1.20.3-0.2-1.2-0.9-0.3
Delay disc. indifference point, 0s delay0.70.72.00.6-0.6-0.8-0.70.6-1.40.7-1.2
Delay disc. indifference point, 16s delay0.00.00.2-0.20.2-0.10.20.10.00.40.1
Delay disc. indifference point, 2s delay0.70.82.2-0.50.50.2-0.91.2-0.11.5-1.2
Delay disc. indifference point, 24s delay0.10.10.2-0.30.30.1-0.30.4-0.00.4-0.4
Delay disc. indifference point, 4s delay1.21.22.1-1.01.00.6-1.31.30.21.4-1.4
Delay disc. indifference point, 8s delay2.33.96.2-1.81.81.6-2.22.51.11.9-2.5
Indifference point function ln k0.41.42.4-1.51.51.3-0.70.51.21.5-0.1
Indifference point function log k0.41.42.4-1.51.51.3-0.70.51.21.5-0.1
Patch foraging total patch changes 0 sec0.10.31.0-0.50.50.6-0.20.30.21.0-0.2
Patch foraging total patch changes 12 sec0.60.91.41.1-1.1-1.00.7-0.7-0.9-1.20.4
Patch foraging total patch changes 18 sec0.10.30.70.5-0.5-0.30.8-0.60.0-0.60.7
Patch foraging total patch changes 24 sec0.30.93.11.1-1.1-1.00.10.1-1.80.9-0.7
Patch foraging total patch changes 6 sec0.40.72.51.0-1.0-0.9-0.1-0.2-1.60.2-0.3
Patch foraging time to switch 0 sec0.20.82.60.4-0.4-0.50.6-1.10.1-1.61.2
Patch foraging water rate 0 sec0.62.27.9-1.11.11.2-0.91.70.42.8-1.5
Patch foraging water rate 12 sec0.72.98.6-1.31.31.3-1.61.80.32.9-1.7
Patch foraging water rate 18 sec0.40.93.60.6-0.6-0.60.50.1-1.41.9-0.3
Patch foraging water rate 24 sec0.30.41.90.2-0.2-0.20.00.1-1.01.4-0.2
Patch foraging water rate 6 sec1.62.46.0-1.31.31.2-1.61.70.42.5-1.7
Seeking ratio, delayed vs. immediate footshock3.75.27.5-2.32.32.2-2.72.51.82.0-2.4
Distance traveled before self-admin0.91.93.1-1.51.51.4-1.81.30.91.1-1.3
Distance traveled after self-admin1.93.44.8-2.12.12.2-1.81.72.21.1-1.3
Extensor digitorum longus weight1.14.39.1-1.41.41.5-2.82.60.32.2-3.0
Bone: elastic displacement0.60.81.61.2-1.2-1.10.8-0.4-1.30.00.2
Bone: elastic work0.30.40.60.7-0.7-0.70.8-0.5-0.7-0.00.5
Bone: endosteal estimation3.99.412.8-3.53.53.6-3.43.03.11.5-2.6
Bone: endosteal perimeter2.15.16.6-2.62.62.6-2.52.32.30.8-2.0
Epididymis fat weight1.47.311.73.3-3.3-3.41.9-2.1-3.3-2.11.2
Delta time in closed arm before/after self-admin1.01.01.91.0-1.0-1.01.4-0.9-0.7-0.41.0
Delta time in open arm before/after self-admin0.60.72.00.4-0.4-0.40.5-1.4-0.3-0.91.3
Diff in mean of infusions in LGA sessions1.73.15.2-2.12.11.8-1.61.72.30.4-1.3
Delay discount exponential model param1.52.02.91.3-1.3-1.01.5-1.7-0.6-1.71.7
Extinction: sum of active levers before priming0.30.41.1-0.80.80.9-0.50.31.10.0-0.1
Active lever presses in extinction session 61.61.62.2-1.41.41.3-1.51.20.91.2-1.2
Bone: final force0.20.40.7-0.90.90.5-0.50.50.7-0.1-0.2
Bone: final moment0.10.20.4-0.60.60.20.00.10.6-0.40.3
Food consumed during 24 hour testing period3.46.99.6-3.13.13.1-1.92.53.02.2-1.7
Glucose0.00.10.10.3-0.3-0.20.1-0.2-0.30.40.1
Heart weight0.71.13.1-0.10.10.1-1.21.3-0.61.3-1.8
Delay discount hyperbolic model param1.51.93.01.3-1.3-0.91.5-1.7-0.6-1.61.7
Intermittent access intake day 1-15 change0.31.53.1-0.90.91.0-1.51.60.80.9-1.8
Intermittent access intake escalation0.21.33.0-0.80.80.7-1.51.60.60.9-1.7
Intermittent access intake escalation 21.93.25.3-1.51.51.6-2.22.21.21.5-2.3
Intermitt. access day 1 inactive lever presses0.00.61.30.5-0.5-0.71.1-0.9-0.1-0.91.1
Intermitt. access day 15 inactive lever presses0.10.72.10.8-0.8-1.40.4-0.3-1.3-0.6-0.0
Intermitt. access escalation Index0.30.91.5-0.90.91.0-0.31.01.11.2-0.7
Intermittent access day 1 total infusions0.20.72.20.2-0.2-0.20.9-0.90.5-1.51.2
Intermittent access day 15 total infusions0.10.20.7-0.30.30.2-0.20.20.8-0.8-0.1
Intermittent access terminal intake (last 3 days)0.40.61.8-0.80.80.9-0.50.71.4-0.3-0.4
Intermittent access total infusions0.50.62.0-0.60.60.70.1-0.21.4-1.10.5
Intermittent access day 1 locomotion0.51.02.10.8-0.8-0.81.3-0.9-0.3-1.51.1
Intermittent access day 15 total locomotion0.10.51.40.5-0.5-0.40.8-0.60.2-1.20.8
Intermittent access total locomotion0.30.31.1-0.60.60.7-0.10.31.1-0.20.1
Intermittent access standard deviation0.00.20.5-0.10.10.2-0.30.40.5-0.7-0.4
Left kidney weight0.21.42.8-1.11.11.1-0.61.71.11.2-1.3
Right kidney weight0.10.92.1-0.50.50.6-0.71.50.31.2-1.4
Cocaine induced anxiety0.10.10.6-0.10.1-0.1-0.0-0.30.5-0.80.3
Post-drug Anxiety0.20.20.40.4-0.4-0.60.1-0.5-0.3-0.60.3
Baseline Anxiety0.91.44.81.4-1.4-1.20.7-0.9-2.20.30.3
Tail length0.10.41.20.6-0.6-0.7-0.20.4-1.1-0.1-0.8
Length with tail0.20.82.60.1-0.10.0-0.71.2-0.71.1-1.6
Length without tail0.94.88.1-1.91.92.0-1.92.81.32.7-2.6
Times rat made contact with spout2.12.53.4-1.91.91.8-1.01.51.81.5-0.9
Lifetime Intake0.50.62.1-0.40.40.40.2-0.41.2-1.40.7
Liver weight, left0.20.30.7-0.30.30.4-0.30.80.20.6-0.8
Liver weight, right0.50.81.9-0.60.60.5-0.71.40.21.2-1.4
Locomotor activity0.20.30.4-0.70.70.5-0.30.50.60.2-0.4
Locomotor testing distance0.10.30.8-0.60.60.5-0.10.30.30.9-0.2
Locomotor testing rearing0.00.20.9-0.30.30.20.00.2-0.21.0-0.2
Locomotion in novel chamber0.10.10.3-0.20.20.40.1-0.10.5-0.20.3
Locomotion in novel chamber post-restriction0.10.40.80.9-0.9-0.70.6-0.5-0.9-0.30.3
Fecal boli incidents, locomotor time 10.61.52.6-1.21.21.0-1.31.61.1-0.2-1.6
Change in fecal boli incidents, locomotor task0.60.71.2-0.70.71.10.0-0.50.91.00.9
Time >=10cm from walls, locomotor time 10.60.71.2-0.90.90.9-1.00.71.1-0.2-0.6
Bouts of movement, locomotor time 10.20.30.7-0.50.5-0.1-0.60.7-0.10.1-0.8
Total resting periods, locomotor time 10.20.20.4-0.60.60.1-0.50.60.10.3-0.6
Rest time, locomotor task time 10.50.92.7-0.90.90.8-0.11.10.71.6-0.6
Distance moved, locomotor task time 10.41.12.21.4-1.4-1.30.3-0.7-1.5-0.60.2
Vertical activity count, locomotor time 10.10.61.10.9-0.9-1.10.2-0.6-0.9-0.90.2
Time >=10cm from walls, locomotor time 20.00.10.40.1-0.10.30.5-0.10.6-0.40.4
Bouts of movement, locomotor time 20.31.02.31.3-1.3-1.30.5-0.3-1.5-0.3-0.2
Total resting periods, locomotor time 20.20.61.51.0-1.0-1.10.4-0.2-1.2-0.2-0.2
Rest time, locomotor task time 20.61.12.40.8-0.8-0.91.6-1.2-0.3-0.61.4
Distance moved, locomotor task time 20.40.61.20.3-0.3-0.3-1.00.6-1.00.8-1.1
Vertical activity count, locomotor time 20.10.20.5-0.20.20.2-0.70.60.10.1-0.7
Light reinforcement 10.73.16.8-1.31.31.4-2.02.50.61.5-2.6
Light reinforcement 20.51.23.1-0.70.70.70.6-0.51.7-1.71.2
Bone: marrow area3.99.513.0-3.53.53.6-3.33.03.21.4-2.5
Bone: maximum diameter5.210.414.9-3.93.93.7-3.13.13.51.7-2.4
Bone: maximum force0.40.81.3-1.11.10.9-0.80.71.1-0.1-0.4
Bone: maximum moment0.20.41.1-0.90.90.7-0.40.31.1-0.30.0
Mean time between licks in bursts0.10.42.00.2-0.2-0.20.6-0.60.4-1.40.7
Mean num. licks in bursts0.20.51.10.7-0.7-0.61.1-0.6-0.50.40.8
Cd content in liver2.42.78.02.0-2.0-2.00.6-0.3-2.80.6-0.5
Co content in liver0.50.61.21.0-1.0-1.10.70.1-1.10.2-0.3
Cu content in liver0.00.00.1-0.10.10.10.20.10.3-0.0-0.0
Fe content in liver1.82.25.1-1.81.81.7-2.30.91.20.6-0.9
K content in liver0.00.00.10.1-0.1-0.10.10.0-0.30.4-0.1
Mg content in liver0.50.51.2-0.70.70.7-0.70.80.31.1-0.7
Mn content in liver1.11.32.9-0.60.60.50.8-0.81.7-1.71.5
Na content in liver0.91.02.6-1.11.11.1-1.60.80.9-0.2-0.9
Rb content in liver0.60.71.6-0.50.50.6-1.20.7-0.21.2-0.9
Se content in liver0.40.51.40.2-0.2-0.20.6-1.10.1-0.81.2
Sr content in liver0.10.10.90.1-0.1-0.1-0.3-0.00.1-0.9-0.1
Zn content in liver1.11.31.91.3-1.3-1.21.4-1.0-1.0-0.70.9
Bone: minimum diameter0.20.41.3-0.80.80.60.00.21.2-0.50.3
Time in familiar zone, hab. session 11.61.72.5-1.51.51.5-1.51.21.6-0.0-1.1
Time in novel zone, hab. session 11.11.32.11.1-1.1-1.11.4-0.8-1.31.10.8
Total zone transitions, hab. session 11.62.34.81.9-1.9-2.00.4-1.0-2.2-0.80.2
Total locomotion distance, hab. session 12.63.78.22.4-2.4-2.60.8-1.3-2.9-0.90.3
Locomotion velocity, hab. session 11.72.44.61.9-1.9-2.00.5-1.1-2.2-1.20.3
Time in familiar zone, hab. session 20.20.20.6-0.60.60.5-0.30.30.20.8-0.2
Time in novel zone, hab. session 20.10.10.2-0.10.10.10.4-0.20.4-0.20.4
Total zone transitions, hab. session 21.11.44.01.4-1.4-1.4-0.60.0-2.0-0.5-1.0
Total locomotion distance, hab. session 21.62.04.81.8-1.8-1.8-0.2-0.3-2.2-1.2-0.7
Locomotion velocity, hab. session 21.72.24.11.9-1.9-1.90.0-0.6-2.0-1.7-0.3
Novel to familiar place preference ratio0.30.40.7-0.50.50.5-0.50.80.50.8-0.7
Novelty place preference0.71.01.3-1.01.00.9-0.71.20.91.1-1.0
Time in novel zone, NPP test1.41.72.9-1.41.41.3-0.91.41.21.7-1.1
Total zone transitions, NPP test0.40.61.80.7-0.7-0.8-0.70.3-1.40.2-1.0
Total locomotion distance, NPP test0.60.92.41.0-1.0-1.0-0.80.2-1.6-0.2-1.0
Locomotion velocity, NPP test1.01.53.41.5-1.5-1.5-0.5-0.4-1.9-1.0-0.6
Intraocular pressure0.30.52.50.3-0.3-0.20.20.4-0.71.6-0.5
Delta distance traveled before/after self-admin0.30.30.8-0.40.40.70.10.60.90.6-0.2
Delta ambulatory time before/after self-admin0.20.41.4-0.50.50.80.30.41.20.60.1
Parametrial fat weight1.22.84.12.0-2.0-1.71.5-1.4-1.5-1.91.0
Pavlov. Cond. lever latency1.52.04.41.2-1.2-1.22.1-1.5-1.20.61.7
Pavlov. Cond. magazine entry latency0.60.75.20.3-0.3-0.2-0.4-0.10.4-2.3-0.2
Pavlov. Cond. change in total contacts0.30.41.80.0-0.0-0.0-0.60.50.3-1.3-0.7
Pavlov. Cond. index score0.60.73.5-0.10.10.2-1.10.50.6-1.9-0.8
Pavlov. Cond. latency score0.60.72.7-0.20.20.3-1.10.60.6-1.6-0.9
Pavlov. Cond. lever contacts1.01.22.5-0.90.90.9-1.61.11.1-1.0-1.3
Pavlov. Cond. magazine entry number0.40.63.8-0.50.50.40.30.1-0.11.90.2
Pavlov. Cond. intertrial magazine entries0.91.13.60.1-0.1-0.1-1.00.7-1.41.9-1.2
Pavlov. Cond. lever-magazine prob. diff.0.70.83.8-0.20.20.2-1.20.50.6-2.0-0.9
Pavlov. Cond. response bias0.50.63.0-0.10.10.1-0.90.50.5-1.7-0.7
Pavlov. Cond. lever latency2.63.74.42.1-2.1-2.11.9-1.9-1.7-1.91.6
Pavlov. Cond. magazine entry latency0.81.23.00.4-0.4-0.31.0-1.50.3-1.71.6
Pavlov. Cond. change in total contacts0.20.40.6-0.70.70.7-0.60.60.50.8-0.4
Pavlov. Cond. index score0.50.81.5-1.11.11.1-0.80.51.20.2-0.2
Pavlov. Cond. latency score0.81.22.4-1.41.41.4-1.00.61.50.4-0.3
Pavlov. Cond. lever contacts2.53.64.6-2.12.12.1-1.81.91.81.8-1.5
Pavlov. Cond. magazine entry number0.30.40.80.3-0.3-0.3-0.10.7-0.70.9-0.9
Pavlov. Cond. intertrial magazine entries0.20.51.5-0.30.30.3-0.81.0-0.00.4-1.2
Pavlov. Cond. lever-magazine prob. diff.0.40.71.4-1.01.01.0-0.70.41.20.0-0.2
Pavlov. Cond. response bias0.40.50.7-0.90.90.9-0.80.60.80.5-0.5
Time in closed arm before self-admin0.81.52.1-1.41.41.3-1.41.01.50.0-0.9
Time in closed arm after self-admin0.20.30.40.6-0.6-0.60.5-0.4-0.4-0.50.4
Time in open arm before self-admin0.91.01.5-1.11.11.1-0.51.11.21.0-0.7
Time in open arm after self-admin1.11.22.6-1.41.41.4-0.80.21.60.20.2
Bone: periosteal estimation2.55.98.8-3.03.02.9-2.32.12.80.9-1.5
Bone: periosteal perimeter1.22.33.9-2.02.01.9-1.31.11.90.4-0.6
Bone: post-yield work2.54.36.1-2.32.32.3-2.52.01.81.2-1.9
Progressive ratio test 1 active lever presses0.30.51.7-0.60.60.70.3-0.11.3-0.70.5
Progressive ratio test 1 breakpoint0.40.62.2-0.70.70.90.30.01.5-0.70.5
Progressive ratio test 1 inactive lever presses0.10.30.7-0.10.10.10.7-0.40.5-0.80.7
Progressive ratio test 2 active lever presses0.20.31.3-0.50.50.5-0.10.31.1-0.60.0
Progressive ratio test 2 breakpoint0.20.21.0-0.40.40.4-0.10.21.0-0.70.1
Progressive ratio test 2 inactive lever presses0.10.41.20.0-0.0-0.10.6-0.60.6-1.10.8
Incentive Sensitization - Responses0.10.20.6-0.20.20.2-0.10.30.7-0.8-0.1
Incentive Sensitization - Breakpoint0.00.10.70.1-0.1-0.10.00.20.4-0.8-0.1
Sum of active levers in priming session hrs 5-60.90.81.7-1.01.00.9-0.80.70.71.3-0.6
Progressive ratio0.20.71.2-0.70.70.7-0.91.10.80.1-1.0
Food seeking constrained by brief footshock4.86.010.5-2.32.32.3-2.52.71.43.2-2.5
Seeking ratio, punishment vs. effort0.40.83.3-0.70.70.8-0.90.70.01.8-0.7
Retroperitoneal fat weight2.19.315.84.0-4.0-3.62.5-2.1-3.8-1.71.2
Reaction time number correct0.10.20.8-0.40.40.4-0.90.2-0.00.4-0.4
Reaction time mean minus median0.31.62.21.4-1.4-1.51.4-1.3-0.9-1.01.2
Reaction time mean minus median AUC0.21.11.61.0-1.0-1.11.2-1.3-0.6-1.01.2
Reaction time num false alarms0.71.21.61.1-1.1-1.21.1-1.3-1.2-0.81.0
Reaction time num false alarms AUC0.51.21.81.1-1.1-1.11.1-1.4-1.2-0.71.1
Reaction time trials correct on left0.10.20.8-0.40.40.4-0.90.2-0.00.4-0.4
Reaction time trials on left0.00.10.6-0.30.30.3-0.80.1-0.10.3-0.3
Reaction time mean0.61.32.40.9-0.9-0.91.4-1.4-0.1-1.51.5
Reaction time mean AUC0.40.91.70.7-0.7-0.81.1-1.2-0.1-1.21.3
Median of all reaction times0.81.32.50.7-0.7-0.81.3-1.40.1-1.61.6
Reaction time omissions2.54.15.22.1-2.1-2.31.7-2.3-2.0-1.81.8
Reaction time false alarm rate1.11.52.41.3-1.3-1.21.5-1.3-1.2-0.71.2
Reaction time premature initiation rate0.20.30.90.1-0.1-0.3-0.20.5-0.60.9-0.7
Reaction time premature initiations0.10.41.2-0.10.1-0.1-0.60.6-0.61.1-0.8
Std. dev. reaction times0.72.22.91.4-1.4-1.61.6-1.7-0.9-1.51.6
Reaction time trials completed0.00.10.6-0.30.30.3-0.80.1-0.10.3-0.3
Reaction time trials AUC0.10.20.8-0.40.40.4-0.90.2-0.00.4-0.4
Run reversals in cocaine runway, females0.70.81.90.8-0.8-0.61.4-1.0-0.5-0.21.2
Run reversals in cocaine runway, males0.91.02.3-0.60.60.5-1.51.2-0.20.9-1.5
Latency to leave start box in cocaine runway0.10.20.3-0.40.40.5-0.50.00.6-0.5-0.0
Latency to leave start box in cocaine runway, F0.00.00.1-0.20.20.2-0.30.20.1-0.1-0.2
Latency to leave start box in cocaine runway, M0.10.10.3-0.20.20.3-0.2-0.40.4-0.50.4
Std. dev. time between licks in bursts0.40.72.1-0.70.70.6-1.50.70.6-0.6-1.0
Total sessions with >9 infusions0.30.41.3-0.70.70.6-0.30.31.1-0.90.0
Short access day 1 total inactive lever presses0.10.20.5-0.20.2-0.30.7-0.10.5-0.60.4
Short access day 10 total inactive lever presses0.00.10.10.3-0.3-0.40.3-0.0-0.3-0.1-0.1
Short access day 1 total infusions0.10.31.1-0.30.30.2-0.0-0.10.8-1.00.2
Short access day 10 total infusions0.81.33.9-0.50.50.40.6-1.01.4-2.01.5
Short access total infusions0.71.04.00.1-0.1-0.20.7-1.00.8-2.01.2
Short access day 1 locomotion0.30.41.0-0.50.50.5-0.71.00.60.3-0.9
Short access day 10 total locomotion0.10.41.2-0.80.80.8-0.40.21.1-0.20.1
Short access total locomotion0.30.51.6-0.60.60.50.20.01.3-1.00.5
One hour access (0.3 mA shock)0.10.20.50.0-0.00.20.3-0.30.7-0.70.5
Compulsive drug intake0.30.51.1-0.70.70.70.4-0.41.10.30.9
One hour access (shock baseline)0.10.21.60.1-0.10.1-0.2-0.10.4-1.3-0.0
Social response proportion0.50.62.00.4-0.4-0.21.1-1.00.2-0.61.4
Social responses0.10.10.3-0.10.10.4-0.1-0.10.6-0.50.2
Social time0.00.10.1-0.20.20.20.0-0.20.3-0.00.3
Soleus weight7.221.130.8-4.44.44.4-5.55.32.64.2-5.3
Bone: stiffness0.00.10.3-0.20.20.1-0.50.2-0.20.2-0.3
Tibialis anterior weight3.813.317.5-3.63.63.7-4.24.02.23.7-3.8
Time to tail flick, vehicle, before self-admin0.10.10.20.5-0.5-0.50.2-0.3-0.4-0.10.1
Time to tail flick, vehicle, after self-admin0.71.42.7-1.51.51.6-1.00.71.60.2-0.3
Time to tail flick, test, before self-admin0.30.31.00.7-0.7-0.70.20.1-1.0-0.2-0.4
Time to tail flick, test, after self-admin0.80.91.6-0.80.80.9-0.81.30.61.0-1.2
Delta time to tail flick, vehicle, before/after SA1.41.42.2-1.41.41.5-1.41.01.10.6-0.8
Delta time to tail flick, test, before/after SA1.21.43.3-1.51.51.5-0.60.81.80.8-0.2
Tibia length1.23.49.3-2.32.32.3-0.71.43.1-0.3-0.4
Ambulatory time before self-admin0.30.81.9-1.01.00.9-1.40.80.60.1-0.9
Ambulatory time after self-admin2.03.25.1-2.12.12.2-1.51.52.21.0-1.0
Bone: tissue strength0.40.50.90.6-0.6-0.60.9-0.8-0.4-0.10.9
Total heroin consumption1.31.52.2-1.21.21.0-1.21.40.81.5-1.4
Bone: trabecular number0.10.31.70.2-0.2-0.2-0.6-0.3-0.1-1.3-0.1
Bone: trabecular spacing1.72.43.61.9-1.9-1.91.7-1.3-1.7-0.51.1
Bone: trabecular thickness0.10.10.2-0.20.20.30.3-0.00.50.10.3
Bone: trabecular tissue density0.10.21.00.1-0.1-0.11.0-0.30.10.30.6
Water consumed over 24 hours1.83.44.7-2.22.22.1-1.61.82.01.4-1.3
Number of responses in last shaping day2.32.94.6-1.81.81.7-1.72.02.20.5-1.6