Leo1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	isoform ratio	NM_001005548.1	0.07	0.05	2.0e-03	0.02	0.01	0.01	0	3.0e-02	5.4e-02	8.6e-02	1.6e-01
2	BLA	isoform ratio	XM_039081146.2	0.07	0.05	1.9e-03	0.03	0.02	0.01	0.01	8.8e-03	4.3e-02	7.2e-02	1.3e-01
3	BLA	alternative polyA	XM_039081146.2	0.09	0.05	1.1e-03	0.03	0.02	0.02	0.01	9.7e-03	4.3e-02	3.4e-02	1.1e-01
4	Adipose	mRNA stability	Leo1	0.06	0.04	2.8e-05	0.05	0.04	0.04	0.04	4.5e-06	3.2e-05	2.2e-05	1.4e-05
5	Adipose	gene expression	Leo1	0.03	0.02	1.5e-03	0	0.01	0.01	0	7.5e-02	2.0e-02	6.2e-02	1.6e-01
6	BLA	alternative polyA	NM_001005548.1	0.07	0.05	7.4e-03	-0	0.01	-0	-0	6.3e-01	1.4e-01	7.3e-01	3.9e-01
7	PL	alternative polyA	XM_039081146.2	0.04	0.02	2.9e-03	0.02	0.02	0.01	0.02	1.4e-03	2.5e-03	1.2e-02	5.0e-03
8	Brain	mRNA stability	Leo1	0.08	0.05	6.6e-06	0.04	0.06	0.05	0.04	6.5e-05	7.6e-06	1.2e-05	6.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.0	0.0	0.1	-0.1	0.1	0.2	0.3	-0.1	-0.2	0.3	-0.1
Area under the delay curve	1.4	1.6	2.5	1.2	-1.2	-0.8	1.4	1.6	0.5	-1.5	-1.6
BMI with tail	2.2	7.6	12.6	2.3	-2.3	-2.6	2.5	3.6	1.9	-3.2	-3.2
BMI without tail	0.9	2.7	6.5	1.0	-1.0	-1.2	1.8	2.4	0.4	-1.8	-2.6
Body weight	1.5	6.5	13.1	1.9	-1.9	-2.2	2.2	3.6	1.4	-2.8	-3.4
Weight adjusted by age	1.5	2.3	2.9	1.7	-1.7	-1.5	1.7	1.6	1.6	-0.7	-1.4
Bone surface	1.3	2.4	4.5	1.7	-1.7	-1.6	2.1	1.6	1.1	-0.7	-1.6
Bone volume	0.7	1.2	2.4	1.1	-1.1	-1.0	1.6	1.2	0.6	-0.6	-1.3
Breakpoint value in progressive ratio session	1.1	1.3	1.8	1.3	-1.3	-1.1	1.3	1.1	1.2	-0.3	-1.0
Number of licking bursts	1.7	2.7	3.5	1.9	-1.9	-1.8	1.8	1.6	1.7	-0.8	-1.5
Context. condit. distance diff. score	0.6	0.7	1.1	1.1	-1.1	-1.0	0.6	0.6	1.1	-0.6	-0.3
Locomotion velocity, session 1	0.6	0.7	1.6	0.4	-0.4	-0.5	0.8	1.1	-0.1	-1.3	-1.2
Locomotion distance, session 1	0.4	0.5	0.9	-0.9	0.9	0.9	0.2	-0.4	-1.0	0.9	-0.2
Locomotion velocity, session 2	0.9	1.0	1.9	0.6	-0.6	-0.8	1.3	1.2	0.1	-1.2	-1.4
Locomotion distance, session 2	0.5	0.7	1.9	-0.8	0.8	0.7	0.8	0.5	-1.4	-0.2	-1.2
Locomotion velocity, session 3	0.1	0.1	0.9	0.1	-0.1	-0.2	0.9	-0.1	-0.3	-0.0	-0.2
Locomotion distance, session 3	1.6	1.7	2.8	-1.5	1.5	1.5	-0.5	-1.5	-1.7	0.9	0.9
Stereotopy head waving bouts, day 3	0.7	0.8	1.7	0.6	-0.6	-0.7	-0.6	-0.8	1.3	0.9	1.3
Stereotopy head waving duration, day 3	0.7	0.8	2.3	1.0	-1.0	-1.1	-0.4	-0.2	1.5	0.1	0.9
Locomotion velocity, session 7	0.1	0.1	0.2	-0.2	0.2	0.2	-0.0	-0.3	-0.2	0.4	0.2
Locomotion distance, session 7	0.1	0.1	0.3	0.1	-0.1	-0.1	0.6	0.3	-0.1	0.0	-0.5
Stereotopy head waving bouts, day 7	0.2	0.2	0.6	0.6	-0.6	-0.6	0.8	-0.0	0.2	-0.5	-0.0
Stereotopy head waving duration, day 7	0.3	0.3	0.9	0.6	-0.6	-0.6	0.9	0.2	0.1	-0.8	-0.3
Locomotion velocity, session 8	0.7	0.9	2.0	0.4	-0.4	-0.6	1.4	0.8	-0.4	-1.4	-1.2
Locomotion distance, session 8	0.4	0.6	2.0	0.4	-0.4	-0.5	1.4	0.8	-0.1	-0.5	-1.2
Degree of sensitization distance	1.3	1.3	2.0	1.3	-1.3	-1.3	0.7	1.3	1.4	-0.6	-0.9
Degree of sensitization stereotypy	0.2	0.2	0.8	0.5	-0.5	-0.4	0.9	0.1	-0.1	-0.6	-0.3
Conditioned locomotion	0.4	0.5	1.0	-0.8	0.8	0.7	-0.8	-0.4	-0.3	1.0	0.4
Cocaine response after cond. corrected	1.9	2.3	3.6	1.7	-1.7	-1.6	1.2	1.5	1.4	-1.9	-1.1
Cocaine response after cond. not corrected	2.8	3.2	4.2	2.1	-2.1	-2.1	1.1	1.8	1.9	-2.0	-1.2
Cocaine response before conditioning	1.1	1.3	2.0	1.2	-1.2	-1.4	0.7	1.4	1.2	-0.8	-1.2
Saline control response	0.4	0.5	1.7	0.1	-0.1	-0.2	-0.8	-1.0	0.5	0.5	1.3
Bone: connectivity density	0.7	1.1	2.2	-1.0	1.0	1.2	-0.3	-1.2	-1.0	1.5	0.7
Bone: cortical apparent density	2.5	3.4	5.6	-1.9	1.9	1.9	-2.4	-2.0	-1.6	0.6	1.9
Bone: cortical area	0.4	0.6	1.7	0.8	-0.8	-0.6	-0.4	-0.4	1.3	0.7	1.0
Bone: cortical porosity	0.7	0.7	2.7	-0.3	0.3	0.2	-0.8	-0.9	0.5	1.6	1.1
Bone: cortical porosity	0.8	0.8	3.3	-0.3	0.3	0.3	-0.7	-1.0	0.5	1.8	1.1
Bone: cortical thickness	2.2	3.7	7.4	-1.4	1.4	1.7	-2.7	-2.4	-0.6	1.6	2.7
Bone: cortical thickness	0.5	0.6	2.0	-0.2	0.2	0.3	-1.4	-0.8	0.3	0.5	1.3
Bone: cortical tissue density	2.3	3.1	5.0	-1.9	1.9	1.9	-2.2	-1.8	-1.7	0.5	1.7
Condit. Reinf. active minus inactive responses	1.0	1.1	3.0	-0.4	0.4	0.3	1.0	1.1	-1.2	-1.3	-1.7
Condit. Reinf. active-inactive response ratio	0.3	0.4	1.9	0.4	-0.4	-0.5	-0.1	0.5	0.1	-1.4	-0.4
Condit. Reinf. active responses	1.4	1.7	5.2	-0.1	0.1	0.1	1.8	1.5	-1.2	-1.3	-2.3
Condit. Reinf. inactive responses	0.8	0.9	2.9	-0.1	0.1	0.2	1.7	1.0	-0.9	-0.2	-1.7
Incentive salience index mean	1.1	1.4	3.7	0.7	-0.7	-0.7	1.8	1.6	0.2	-0.5	-1.9
Condit. Reinf. lever presses	1.7	2.4	3.9	1.5	-1.5	-1.5	2.0	1.3	1.9	1.1	-1.3
Condit. Reinf. active minus inactive responses	1.4	1.8	6.3	1.2	-1.2	-1.2	1.2	1.2	0.2	-2.5	-1.1
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.8	0.8	-0.8	-0.8	0.2	0.1	0.3	-1.4	0.1
Condit. Reinf. active responses	1.9	2.7	6.5	1.2	-1.2	-1.4	1.6	1.9	0.3	-2.6	-2.0
Condit. Reinf. inactive responses	1.0	1.4	3.7	0.7	-0.7	-0.7	1.3	1.7	0.3	-0.9	-1.9
Condit. Reinf. lever presses	1.8	2.5	3.8	1.9	-1.9	-1.9	1.0	1.2	1.9	-1.5	-0.7
Condit. Reinf. lever reinforcers received	1.7	2.3	6.4	1.1	-1.1	-1.2	1.4	1.8	0.3	-2.5	-1.8
Conditioned reinforcement - actives	0.4	0.7	2.1	0.9	-0.9	-1.0	0.5	0.4	1.5	0.4	-0.1
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.0	0.0	-0.1	0.3	0.3	0.2	-0.2	-0.3
Conditioned locomotion	0.3	0.3	0.9	-0.5	0.5	0.6	-1.0	-0.4	-0.1	0.7	0.6
Patch foraging indifference point 0 sec	0.2	0.4	1.1	0.7	-0.7	-0.8	0.5	0.5	0.3	-1.1	-0.4
Patch foraging indifference point AUC	0.6	0.9	1.7	-1.3	1.3	1.2	-0.3	-0.2	-1.2	0.9	-0.3
Delay disc. indifference point, 0s delay	0.7	0.7	2.0	-0.6	0.6	0.8	0.7	0.6	-1.4	-0.7	-1.2
Delay disc. indifference point, 16s delay	0.0	0.0	0.2	0.2	-0.2	0.1	-0.2	0.1	0.0	-0.4	0.1
Delay disc. indifference point, 2s delay	0.7	0.8	2.2	0.5	-0.5	-0.2	0.9	1.2	-0.1	-1.5	-1.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.3	-0.3	-0.1	0.3	0.4	-0.0	-0.4	-0.4
Delay disc. indifference point, 4s delay	1.2	1.2	2.1	1.0	-1.0	-0.6	1.3	1.3	0.2	-1.4	-1.4
Delay disc. indifference point, 8s delay	3.3	3.9	6.2	1.8	-1.8	-1.6	2.2	2.5	1.1	-1.9	-2.5
Indifference point function ln k	0.8	1.4	2.4	1.5	-1.5	-1.3	0.7	0.5	1.2	-1.5	-0.1
Indifference point function log k	0.8	1.4	2.4	1.5	-1.5	-1.3	0.7	0.5	1.2	-1.5	-0.1
Patch foraging total patch changes 0 sec	0.1	0.3	1.0	0.5	-0.5	-0.6	0.2	0.3	0.2	-1.0	-0.2
Patch foraging total patch changes 12 sec	0.7	0.9	1.4	-1.1	1.1	1.0	-0.7	-0.7	-0.9	1.2	0.4
Patch foraging total patch changes 18 sec	0.2	0.3	0.7	-0.5	0.5	0.3	-0.8	-0.6	0.0	0.6	0.7
Patch foraging total patch changes 24 sec	0.6	0.9	3.1	-1.1	1.1	1.0	-0.1	0.1	-1.8	-0.9	-0.7
Patch foraging total patch changes 6 sec	0.5	0.7	2.5	-1.0	1.0	0.9	0.1	-0.2	-1.6	-0.2	-0.3
Patch foraging time to switch 0 sec	0.4	0.8	2.6	-0.4	0.4	0.5	-0.6	-1.1	0.1	1.6	1.2
Patch foraging water rate 0 sec	1.1	2.2	7.9	1.1	-1.1	-1.2	0.9	1.7	0.4	-2.8	-1.5
Patch foraging water rate 12 sec	1.4	2.9	8.6	1.3	-1.3	-1.3	1.6	1.8	0.3	-2.9	-1.7
Patch foraging water rate 18 sec	0.6	0.9	3.6	-0.6	0.6	0.6	-0.5	0.1	-1.4	-1.9	-0.3
Patch foraging water rate 24 sec	0.3	0.4	1.9	-0.2	0.2	0.2	-0.0	0.1	-1.0	-1.4	-0.2
Patch foraging water rate 6 sec	1.6	2.4	6.0	1.3	-1.3	-1.2	1.6	1.7	0.4	-2.5	-1.7
Seeking ratio, delayed vs. immediate footshock	4.3	5.2	7.5	2.3	-2.3	-2.2	2.7	2.5	1.8	-2.0	-2.4
Distance traveled before self-admin	1.5	1.9	3.1	1.5	-1.5	-1.4	1.8	1.3	0.9	-1.1	-1.3
Distance traveled after self-admin	2.8	3.4	4.8	2.1	-2.1	-2.2	1.8	1.7	2.2	-1.1	-1.3
Extensor digitorum longus weight	1.1	4.3	9.1	1.4	-1.4	-1.5	2.8	2.6	0.3	-2.2	-3.0
Bone: elastic displacement	0.7	0.8	1.6	-1.2	1.2	1.1	-0.8	-0.4	-1.3	-0.0	0.2
Bone: elastic work	0.3	0.4	0.6	-0.7	0.7	0.7	-0.8	-0.5	-0.7	0.0	0.5
Bone: endosteal estimation	4.3	9.4	12.8	3.5	-3.5	-3.6	3.4	3.0	3.1	-1.5	-2.6
Bone: endosteal perimeter	2.4	5.1	6.6	2.6	-2.6	-2.6	2.5	2.3	2.3	-0.8	-2.0
Epididymis fat weight	2.1	7.3	11.7	-3.3	3.3	3.4	-1.9	-2.1	-3.3	2.1	1.2
Delta time in closed arm before/after self-admin	1.0	1.0	1.9	-1.0	1.0	1.0	-1.4	-0.9	-0.7	0.4	1.0
Delta time in open arm before/after self-admin	0.7	0.7	2.0	-0.4	0.4	0.4	-0.5	-1.4	-0.3	0.9	1.3
Diff in mean of infusions in LGA sessions	2.5	3.1	5.2	2.1	-2.1	-1.8	1.6	1.7	2.3	-0.4	-1.3
Delay discount exponential model param	1.8	2.0	2.9	-1.3	1.3	1.0	-1.5	-1.7	-0.6	1.7	1.7
Extinction: sum of active levers before priming	0.4	0.4	1.1	0.8	-0.8	-0.9	0.5	0.3	1.1	-0.0	-0.1
Active lever presses in extinction session 6	1.6	1.6	2.2	1.4	-1.4	-1.3	1.5	1.2	0.9	-1.2	-1.2
Bone: final force	0.2	0.4	0.7	0.9	-0.9	-0.5	0.5	0.5	0.7	0.1	-0.2
Bone: final moment	0.1	0.2	0.4	0.6	-0.6	-0.2	-0.0	0.1	0.6	0.4	0.3
Food consumed during 24 hour testing period	5.0	6.9	9.6	3.1	-3.1	-3.1	1.9	2.5	3.0	-2.2	-1.7
Glucose	0.0	0.1	0.1	-0.3	0.3	0.2	-0.1	-0.2	-0.3	-0.4	0.1
Heart weight	0.7	1.1	3.1	0.1	-0.1	-0.1	1.2	1.3	-0.6	-1.3	-1.8
Delay discount hyperbolic model param	1.7	1.9	3.0	-1.3	1.3	0.9	-1.5	-1.7	-0.6	1.6	1.7
Intermittent access intake day 1-15 change	0.7	1.5	3.1	0.9	-0.9	-1.0	1.5	1.6	0.8	-0.9	-1.8
Intermittent access intake escalation	0.6	1.3	3.0	0.8	-0.8	-0.7	1.5	1.6	0.6	-0.9	-1.7
Intermittent access intake escalation 2	2.8	3.2	5.3	1.5	-1.5	-1.6	2.2	2.2	1.2	-1.5	-2.3
Intermitt. access day 1 inactive lever presses	0.2	0.6	1.3	-0.5	0.5	0.7	-1.1	-0.9	-0.1	0.9	1.1
Intermitt. access day 15 inactive lever presses	0.3	0.7	2.1	-0.8	0.8	1.4	-0.4	-0.3	-1.3	0.6	-0.0
Intermitt. access escalation Index	0.6	0.9	1.5	0.9	-0.9	-1.0	0.3	1.0	1.1	-1.2	-0.7
Intermittent access day 1 total infusions	0.4	0.7	2.2	-0.2	0.2	0.2	-0.9	-0.9	0.5	1.5	1.2
Intermittent access day 15 total infusions	0.1	0.2	0.7	0.3	-0.3	-0.2	0.2	0.2	0.8	0.8	-0.1
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.8	0.8	-0.8	-0.9	0.5	0.7	1.4	0.3	-0.4
Intermittent access total infusions	0.5	0.6	2.0	0.6	-0.6	-0.7	-0.1	-0.2	1.4	1.1	0.5
Intermittent access day 1 locomotion	0.8	1.0	2.1	-0.8	0.8	0.8	-1.3	-0.9	-0.3	1.5	1.1
Intermittent access day 15 total locomotion	0.3	0.5	1.4	-0.5	0.5	0.4	-0.8	-0.6	0.2	1.2	0.8
Intermittent access total locomotion	0.3	0.3	1.1	0.6	-0.6	-0.7	0.1	0.3	1.1	0.2	0.1
Intermittent access standard deviation	0.1	0.2	0.5	0.1	-0.1	-0.2	0.3	0.4	0.5	0.7	-0.4
Left kidney weight	0.3	1.4	2.8	1.1	-1.1	-1.1	0.6	1.7	1.1	-1.2	-1.3
Right kidney weight	0.2	0.9	2.1	0.5	-0.5	-0.6	0.7	1.5	0.3	-1.2	-1.4
Cocaine induced anxiety	0.1	0.1	0.6	0.1	-0.1	0.1	0.0	-0.3	0.5	0.8	0.3
Post-drug Anxiety	0.2	0.2	0.4	-0.4	0.4	0.6	-0.1	-0.5	-0.3	0.6	0.3
Baseline Anxiety	1.2	1.4	4.8	-1.4	1.4	1.2	-0.7	-0.9	-2.2	-0.3	0.3
Tail length	0.1	0.4	1.2	-0.6	0.6	0.7	0.2	0.4	-1.1	0.1	-0.8
Length with tail	0.2	0.8	2.6	-0.1	0.1	-0.0	0.7	1.2	-0.7	-1.1	-1.6
Length without tail	1.5	4.8	8.1	1.9	-1.9	-2.0	1.9	2.8	1.3	-2.7	-2.6
Times rat made contact with spout	2.1	2.5	3.4	1.9	-1.9	-1.8	1.0	1.5	1.8	-1.5	-0.9
Lifetime Intake	0.5	0.6	2.1	0.4	-0.4	-0.4	-0.2	-0.4	1.2	1.4	0.7
Liver weight, left	0.2	0.3	0.7	0.3	-0.3	-0.4	0.3	0.8	0.2	-0.6	-0.8
Liver weight, right	0.5	0.8	1.9	0.6	-0.6	-0.5	0.7	1.4	0.2	-1.2	-1.4
Locomotor activity	0.2	0.3	0.4	0.7	-0.7	-0.5	0.3	0.5	0.6	-0.2	-0.4
Locomotor testing distance	0.1	0.3	0.8	0.6	-0.6	-0.5	0.1	0.3	0.3	-0.9	-0.2
Locomotor testing rearing	0.1	0.2	0.9	0.3	-0.3	-0.2	-0.0	0.2	-0.2	-1.0	-0.2
Locomotion in novel chamber	0.1	0.1	0.3	0.2	-0.2	-0.4	-0.1	-0.1	0.5	0.2	0.3
Locomotion in novel chamber post-restriction	0.3	0.4	0.8	-0.9	0.9	0.7	-0.6	-0.5	-0.9	0.3	0.3
Fecal boli incidents, locomotor time 1	1.0	1.5	2.6	1.2	-1.2	-1.0	1.3	1.6	1.1	0.2	-1.6
Change in fecal boli incidents, locomotor task	0.7	0.7	1.2	0.7	-0.7	-1.1	-0.0	-0.5	0.9	-1.0	0.9
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.2	0.9	-0.9	-0.9	1.0	0.7	1.1	0.2	-0.6
Bouts of movement, locomotor time 1	0.2	0.3	0.7	0.5	-0.5	0.1	0.6	0.7	-0.1	-0.1	-0.8
Total resting periods, locomotor time 1	0.2	0.2	0.4	0.6	-0.6	-0.1	0.5	0.6	0.1	-0.3	-0.6
Rest time, locomotor task time 1	0.7	0.9	2.7	0.9	-0.9	-0.8	0.1	1.1	0.7	-1.6	-0.6
Distance moved, locomotor task time 1	0.7	1.1	2.2	-1.4	1.4	1.3	-0.3	-0.7	-1.5	0.6	0.2
Vertical activity count, locomotor time 1	0.3	0.6	1.1	-0.9	0.9	1.1	-0.2	-0.6	-0.9	0.9	0.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	-0.1	0.1	-0.3	-0.5	-0.1	0.6	0.4	0.4
Bouts of movement, locomotor time 2	0.6	1.0	2.3	-1.3	1.3	1.3	-0.5	-0.3	-1.5	0.3	-0.2
Total resting periods, locomotor time 2	0.4	0.6	1.5	-1.0	1.0	1.1	-0.4	-0.2	-1.2	0.2	-0.2
Rest time, locomotor task time 2	0.9	1.1	2.4	-0.8	0.8	0.9	-1.6	-1.2	-0.3	0.6	1.4
Distance moved, locomotor task time 2	0.5	0.6	1.2	-0.3	0.3	0.3	1.0	0.6	-1.0	-0.8	-1.1
Vertical activity count, locomotor time 2	0.1	0.2	0.5	0.2	-0.2	-0.2	0.7	0.6	0.1	-0.1	-0.7
Light reinforcement 1	1.3	3.1	6.8	1.3	-1.3	-1.4	2.0	2.5	0.6	-1.5	-2.6
Light reinforcement 2	0.8	1.2	3.1	0.7	-0.7	-0.7	-0.6	-0.5	1.7	1.7	1.2
Bone: marrow area	4.3	9.5	13.0	3.5	-3.5	-3.6	3.3	3.0	3.2	-1.4	-2.5
Bone: maximum diameter	5.6	10.4	14.9	3.9	-3.9	-3.7	3.1	3.1	3.5	-1.7	-2.4
Bone: maximum force	0.4	0.8	1.3	1.1	-1.1	-0.9	0.8	0.7	1.1	0.1	-0.4
Bone: maximum moment	0.3	0.4	1.1	0.9	-0.9	-0.7	0.4	0.3	1.1	0.3	0.0
Mean time between licks in bursts	0.2	0.4	2.0	-0.2	0.2	0.2	-0.6	-0.6	0.4	1.4	0.7
Mean num. licks in bursts	0.3	0.5	1.1	-0.7	0.7	0.6	-1.1	-0.6	-0.5	-0.4	0.8
Cd content in liver	2.4	2.7	8.0	-2.0	2.0	2.0	-0.6	-0.3	-2.8	-0.6	-0.5
Co content in liver	0.6	0.6	1.2	-1.0	1.0	1.1	-0.7	0.1	-1.1	-0.2	-0.3
Cu content in liver	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.2	0.1	0.3	0.0	-0.0
Fe content in liver	1.8	2.2	5.1	1.8	-1.8	-1.7	2.3	0.9	1.2	-0.6	-0.9
K content in liver	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	0.0	-0.3	-0.4	-0.1
Mg content in liver	0.5	0.5	1.2	0.7	-0.7	-0.7	0.7	0.8	0.3	-1.1	-0.7
Mn content in liver	1.2	1.3	2.9	0.6	-0.6	-0.5	-0.8	-0.8	1.7	1.7	1.5
Na content in liver	0.9	1.0	2.6	1.1	-1.1	-1.1	1.6	0.8	0.9	0.2	-0.9
Rb content in liver	0.6	0.7	1.6	0.5	-0.5	-0.6	1.2	0.7	-0.2	-1.2	-0.9
Se content in liver	0.4	0.5	1.4	-0.2	0.2	0.2	-0.6	-1.1	0.1	0.8	1.2
Sr content in liver	0.2	0.1	0.9	-0.1	0.1	0.1	0.3	-0.0	0.1	0.9	-0.1
Zn content in liver	1.2	1.3	1.9	-1.3	1.3	1.2	-1.4	-1.0	-1.0	0.7	0.9
Bone: minimum diameter	0.2	0.4	1.3	0.8	-0.8	-0.6	-0.0	0.2	1.2	0.5	0.3
Time in familiar zone, hab. session 1	1.8	1.7	2.5	1.5	-1.5	-1.5	1.5	1.2	1.6	0.0	-1.1
Time in novel zone, hab. session 1	1.3	1.3	2.1	-1.1	1.1	1.1	-1.4	-0.8	-1.3	-1.1	0.8
Total zone transitions, hab. session 1	1.6	2.3	4.8	-1.9	1.9	2.0	-0.4	-1.0	-2.2	0.8	0.2
Total locomotion distance, hab. session 1	2.6	3.7	8.2	-2.4	2.4	2.6	-0.8	-1.3	-2.9	0.9	0.3
Locomotion velocity, hab. session 1	1.7	2.4	4.6	-1.9	1.9	2.0	-0.5	-1.1	-2.2	1.2	0.3
Time in familiar zone, hab. session 2	0.2	0.2	0.6	0.6	-0.6	-0.5	0.3	0.3	0.2	-0.8	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.1	-0.1	-0.1	-0.4	-0.2	0.4	0.2	0.4
Total zone transitions, hab. session 2	1.1	1.4	4.0	-1.4	1.4	1.4	0.6	0.0	-2.0	0.5	-1.0
Total locomotion distance, hab. session 2	1.6	2.0	4.8	-1.8	1.8	1.8	0.2	-0.3	-2.2	1.2	-0.7
Locomotion velocity, hab. session 2	1.7	2.2	4.1	-1.9	1.9	1.9	-0.0	-0.6	-2.0	1.7	-0.3
Novel to familiar place preference ratio	0.3	0.4	0.7	0.5	-0.5	-0.5	0.5	0.8	0.5	-0.8	-0.7
Novelty place preference	0.9	1.0	1.3	1.0	-1.0	-0.9	0.7	1.2	0.9	-1.1	-1.0
Time in novel zone, NPP test	1.6	1.7	2.9	1.4	-1.4	-1.3	0.9	1.4	1.2	-1.7	-1.1
Total zone transitions, NPP test	0.4	0.6	1.8	-0.7	0.7	0.8	0.7	0.3	-1.4	-0.2	-1.0
Total locomotion distance, NPP test	0.7	0.9	2.4	-1.0	1.0	1.0	0.8	0.2	-1.6	0.2	-1.0
Locomotion velocity, NPP test	1.0	1.5	3.4	-1.5	1.5	1.5	0.5	-0.4	-1.9	1.0	-0.6
Intraocular pressure	0.3	0.5	2.5	-0.3	0.3	0.2	-0.2	0.4	-0.7	-1.6	-0.5
Delta distance traveled before/after self-admin	0.3	0.3	0.8	0.4	-0.4	-0.7	-0.1	0.6	0.9	-0.6	-0.2
Delta ambulatory time before/after self-admin	0.3	0.4	1.4	0.5	-0.5	-0.8	-0.3	0.4	1.2	-0.6	0.1
Parametrial fat weight	1.2	2.8	4.1	-2.0	2.0	1.7	-1.5	-1.4	-1.5	1.9	1.0
Pavlov. Cond. lever latency	1.5	2.0	4.4	-1.2	1.2	1.2	-2.1	-1.5	-1.2	-0.6	1.7
Pavlov. Cond. magazine entry latency	0.6	0.7	5.2	-0.3	0.3	0.2	0.4	-0.1	0.4	2.3	-0.2
Pavlov. Cond. change in total contacts	0.3	0.4	1.8	-0.0	0.0	0.0	0.6	0.5	0.3	1.3	-0.7
Pavlov. Cond. index score	0.6	0.7	3.5	0.1	-0.1	-0.2	1.1	0.5	0.6	1.9	-0.8
Pavlov. Cond. latency score	0.6	0.7	2.7	0.2	-0.2	-0.3	1.1	0.6	0.6	1.6	-0.9
Pavlov. Cond. lever contacts	1.0	1.2	2.5	0.9	-0.9	-0.9	1.6	1.1	1.1	1.0	-1.3
Pavlov. Cond. magazine entry number	0.4	0.6	3.8	0.5	-0.5	-0.4	-0.3	0.1	-0.1	-1.9	0.2
Pavlov. Cond. intertrial magazine entries	0.9	1.1	3.6	-0.1	0.1	0.1	1.0	0.7	-1.4	-1.9	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	3.8	0.2	-0.2	-0.2	1.2	0.5	0.6	2.0	-0.9
Pavlov. Cond. response bias	0.5	0.6	3.0	0.1	-0.1	-0.1	0.9	0.5	0.5	1.7	-0.7
Pavlov. Cond. lever latency	2.7	3.7	4.4	-2.1	2.1	2.1	-1.9	-1.9	-1.7	1.9	1.6
Pavlov. Cond. magazine entry latency	1.0	1.2	3.0	-0.4	0.4	0.3	-1.0	-1.5	0.3	1.7	1.6
Pavlov. Cond. change in total contacts	0.2	0.4	0.6	0.7	-0.7	-0.7	0.6	0.6	0.5	-0.8	-0.4
Pavlov. Cond. index score	0.6	0.8	1.5	1.1	-1.1	-1.1	0.8	0.5	1.2	-0.2	-0.2
Pavlov. Cond. latency score	0.9	1.2	2.4	1.4	-1.4	-1.4	1.0	0.6	1.5	-0.4	-0.3
Pavlov. Cond. lever contacts	2.6	3.6	4.6	2.1	-2.1	-2.1	1.8	1.9	1.8	-1.8	-1.5
Pavlov. Cond. magazine entry number	0.3	0.4	0.8	-0.3	0.3	0.3	0.1	0.7	-0.7	-0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.3	0.5	1.5	0.3	-0.3	-0.3	0.8	1.0	-0.0	-0.4	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.4	1.0	-1.0	-1.0	0.7	0.4	1.2	-0.0	-0.2
Pavlov. Cond. response bias	0.4	0.5	0.7	0.9	-0.9	-0.9	0.8	0.6	0.8	-0.5	-0.5
Time in closed arm before self-admin	1.1	1.5	2.1	1.4	-1.4	-1.3	1.4	1.0	1.5	-0.0	-0.9
Time in closed arm after self-admin	0.3	0.3	0.4	-0.6	0.6	0.6	-0.5	-0.4	-0.4	0.5	0.4
Time in open arm before self-admin	1.0	1.0	1.5	1.1	-1.1	-1.1	0.5	1.1	1.2	-1.0	-0.7
Time in open arm after self-admin	1.1	1.2	2.6	1.4	-1.4	-1.4	0.8	0.2	1.6	-0.2	0.2
Bone: periosteal estimation	2.8	5.9	8.8	3.0	-3.0	-2.9	2.3	2.1	2.8	-0.9	-1.5
Bone: periosteal perimeter	1.3	2.3	3.9	2.0	-2.0	-1.9	1.3	1.1	1.9	-0.4	-0.6
Bone: post-yield work	2.9	4.3	6.1	2.3	-2.3	-2.3	2.5	2.0	1.8	-1.2	-1.9
Progressive ratio test 1 active lever presses	0.4	0.5	1.7	0.6	-0.6	-0.7	-0.3	-0.1	1.3	0.7	0.5
Progressive ratio test 1 breakpoint	0.5	0.6	2.2	0.7	-0.7	-0.9	-0.3	0.0	1.5	0.7	0.5
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.7	0.1	-0.1	-0.1	-0.7	-0.4	0.5	0.8	0.7
Progressive ratio test 2 active lever presses	0.3	0.3	1.3	0.5	-0.5	-0.5	0.1	0.3	1.1	0.6	0.0
Progressive ratio test 2 breakpoint	0.2	0.2	1.0	0.4	-0.4	-0.4	0.1	0.2	1.0	0.7	0.1
Progressive ratio test 2 inactive lever presses	0.2	0.4	1.2	-0.0	0.0	0.1	-0.6	-0.6	0.6	1.1	0.8
Incentive Sensitization - Responses	0.1	0.2	0.6	0.2	-0.2	-0.2	0.1	0.3	0.7	0.8	-0.1
Incentive Sensitization - Breakpoint	0.1	0.1	0.7	-0.1	0.1	0.1	-0.0	0.2	0.4	0.8	-0.1
Sum of active levers in priming session hrs 5-6	0.9	0.8	1.7	1.0	-1.0	-0.9	0.8	0.7	0.7	-1.3	-0.6
Progressive ratio	0.4	0.7	1.2	0.7	-0.7	-0.7	0.9	1.1	0.8	-0.1	-1.0
Food seeking constrained by brief footshock	4.9	6.0	10.5	2.3	-2.3	-2.3	2.5	2.7	1.4	-3.2	-2.5
Seeking ratio, punishment vs. effort	0.6	0.8	3.3	0.7	-0.7	-0.8	0.9	0.7	0.0	-1.8	-0.7
Retroperitoneal fat weight	2.2	9.3	15.8	-4.0	4.0	3.6	-2.5	-2.1	-3.8	1.7	1.2
Reaction time number correct	0.1	0.2	0.8	0.4	-0.4	-0.4	0.9	0.2	-0.0	-0.4	-0.4
Reaction time mean minus median	0.7	1.6	2.2	-1.4	1.4	1.5	-1.4	-1.3	-0.9	1.0	1.2
Reaction time mean minus median AUC	0.4	1.1	1.6	-1.0	1.0	1.1	-1.2	-1.3	-0.6	1.0	1.2
Reaction time num false alarms	0.8	1.2	1.6	-1.1	1.1	1.2	-1.1	-1.3	-1.2	0.8	1.0
Reaction time num false alarms AUC	0.8	1.2	1.8	-1.1	1.1	1.1	-1.1	-1.4	-1.2	0.7	1.1
Reaction time trials correct on left	0.1	0.2	0.8	0.4	-0.4	-0.4	0.9	0.2	-0.0	-0.4	-0.4
Reaction time trials on left	0.1	0.1	0.6	0.3	-0.3	-0.3	0.8	0.1	-0.1	-0.3	-0.3
Reaction time mean	0.8	1.3	2.4	-0.9	0.9	0.9	-1.4	-1.4	-0.1	1.5	1.5
Reaction time mean AUC	0.6	0.9	1.7	-0.7	0.7	0.8	-1.1	-1.2	-0.1	1.2	1.3
Median of all reaction times	0.9	1.3	2.5	-0.7	0.7	0.8	-1.3	-1.4	0.1	1.6	1.6
Reaction time omissions	2.8	4.1	5.2	-2.1	2.1	2.3	-1.7	-2.3	-2.0	1.8	1.8
Reaction time false alarm rate	1.1	1.5	2.4	-1.3	1.3	1.2	-1.5	-1.3	-1.2	0.7	1.2
Reaction time premature initiation rate	0.2	0.3	0.9	-0.1	0.1	0.3	0.2	0.5	-0.6	-0.9	-0.7
Reaction time premature initiations	0.2	0.4	1.2	0.1	-0.1	0.1	0.6	0.6	-0.6	-1.1	-0.8
Std. dev. reaction times	1.2	2.2	2.9	-1.4	1.4	1.6	-1.6	-1.7	-0.9	1.5	1.6
Reaction time trials completed	0.1	0.1	0.6	0.3	-0.3	-0.3	0.8	0.1	-0.1	-0.3	-0.3
Reaction time trials AUC	0.1	0.2	0.8	0.4	-0.4	-0.4	0.9	0.2	-0.0	-0.4	-0.4
Run reversals in cocaine runway, females	0.8	0.8	1.9	-0.8	0.8	0.6	-1.4	-1.0	-0.5	0.2	1.2
Run reversals in cocaine runway, males	1.0	1.0	2.3	0.6	-0.6	-0.5	1.5	1.2	-0.2	-0.9	-1.5
Latency to leave start box in cocaine runway	0.2	0.2	0.3	0.4	-0.4	-0.5	0.5	0.0	0.6	0.5	-0.0
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.2	-0.2	-0.2	0.3	0.2	0.1	0.1	-0.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.2	-0.2	-0.3	0.2	-0.4	0.4	0.5	0.4
Std. dev. time between licks in bursts	0.5	0.7	2.1	0.7	-0.7	-0.6	1.5	0.7	0.6	0.6	-1.0
Total sessions with >9 infusions	0.3	0.4	1.3	0.7	-0.7	-0.6	0.3	0.3	1.1	0.9	0.0
Short access day 1 total inactive lever presses	0.1	0.2	0.5	0.2	-0.2	0.3	-0.7	-0.1	0.5	0.6	0.4
Short access day 10 total inactive lever presses	0.0	0.1	0.1	-0.3	0.3	0.4	-0.3	-0.0	-0.3	0.1	-0.1
Short access day 1 total infusions	0.2	0.3	1.1	0.3	-0.3	-0.2	0.0	-0.1	0.8	1.0	0.2
Short access day 10 total infusions	1.0	1.3	3.9	0.5	-0.5	-0.4	-0.6	-1.0	1.4	2.0	1.5
Short access total infusions	0.7	1.0	4.0	-0.1	0.1	0.2	-0.7	-1.0	0.8	2.0	1.2
Short access day 1 locomotion	0.4	0.4	1.0	0.5	-0.5	-0.5	0.7	1.0	0.6	-0.3	-0.9
Short access day 10 total locomotion	0.2	0.4	1.2	0.8	-0.8	-0.8	0.4	0.2	1.1	0.2	0.1
Short access total locomotion	0.4	0.5	1.6	0.6	-0.6	-0.5	-0.2	0.0	1.3	1.0	0.5
One hour access (0.3 mA shock)	0.1	0.2	0.5	-0.0	0.0	-0.2	-0.3	-0.3	0.7	0.7	0.5
Compulsive drug intake	0.4	0.5	1.1	0.7	-0.7	-0.7	-0.4	-0.4	1.1	-0.3	0.9
One hour access (shock baseline)	0.2	0.2	1.6	-0.1	0.1	-0.1	0.2	-0.1	0.4	1.3	-0.0
Social response proportion	0.6	0.6	2.0	-0.4	0.4	0.2	-1.1	-1.0	0.2	0.6	1.4
Social responses	0.1	0.1	0.3	0.1	-0.1	-0.4	0.1	-0.1	0.6	0.5	0.2
Social time	0.0	0.1	0.1	0.2	-0.2	-0.2	-0.0	-0.2	0.3	0.0	0.3
Soleus weight	7.2	21.1	30.8	4.4	-4.4	-4.4	5.5	5.3	2.6	-4.2	-5.3
Bone: stiffness	0.0	0.1	0.3	0.2	-0.2	-0.1	0.5	0.2	-0.2	-0.2	-0.3
Tibialis anterior weight	3.9	13.3	17.5	3.6	-3.6	-3.7	4.2	4.0	2.2	-3.7	-3.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.5	0.5	0.5	-0.2	-0.3	-0.4	0.1	0.1
Time to tail flick, vehicle, after self-admin	1.1	1.4	2.7	1.5	-1.5	-1.6	1.0	0.7	1.6	-0.2	-0.3
Time to tail flick, test, before self-admin	0.3	0.3	1.0	-0.7	0.7	0.7	-0.2	0.1	-1.0	0.2	-0.4
Time to tail flick, test, after self-admin	0.8	0.9	1.6	0.8	-0.8	-0.9	0.8	1.3	0.6	-1.0	-1.2
Delta time to tail flick, vehicle, before/after SA	1.5	1.4	2.2	1.4	-1.4	-1.5	1.4	1.0	1.1	-0.6	-0.8
Delta time to tail flick, test, before/after SA	1.4	1.4	3.3	1.5	-1.5	-1.5	0.6	0.8	1.8	-0.8	-0.2
Tibia length	1.2	3.4	9.3	2.3	-2.3	-2.3	0.7	1.4	3.1	0.3	-0.4
Ambulatory time before self-admin	0.5	0.8	1.9	1.0	-1.0	-0.9	1.4	0.8	0.6	-0.1	-0.9
Ambulatory time after self-admin	2.7	3.2	5.1	2.1	-2.1	-2.2	1.5	1.5	2.2	-1.0	-1.0
Bone: tissue strength	0.5	0.5	0.9	-0.6	0.6	0.6	-0.9	-0.8	-0.4	0.1	0.9
Total heroin consumption	1.3	1.5	2.2	1.2	-1.2	-1.0	1.2	1.4	0.8	-1.5	-1.4
Bone: trabecular number	0.2	0.3	1.7	-0.2	0.2	0.2	0.6	-0.3	-0.1	1.3	-0.1
Bone: trabecular spacing	1.8	2.4	3.6	-1.9	1.9	1.9	-1.7	-1.3	-1.7	0.5	1.1
Bone: trabecular thickness	0.1	0.1	0.2	0.2	-0.2	-0.3	-0.3	-0.0	0.5	-0.1	0.3
Bone: trabecular tissue density	0.1	0.2	1.0	-0.1	0.1	0.1	-1.0	-0.3	0.1	-0.3	0.6
Water consumed over 24 hours	2.6	3.4	4.7	2.2	-2.2	-2.1	1.6	1.8	2.0	-1.4	-1.3
Number of responses in last shaping day	2.7	2.9	4.6	1.8	-1.8	-1.7	1.7	2.0	2.2	-0.5	-1.6