Hub : Genes

Lasp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Lasp1	0.02	0.02	2.8e-03	0.02	0.02	0.02	0.02	2.8e-03	4.8e-03	4.6e-03	4.9e-03
2	PL	isoform ratio	XM_063268798.1	0.03	0.03	8.1e-03	0.01	0.01	0	0	1.2e-02	5.1e-02	2.0e-01	7.5e-02
3	PL	alternative TSS	XM_063268798.1	0.03	0.02	1.0e-03	0.03	0.02	0.02	0.02	6.7e-04	2.2e-03	2.1e-03	2.5e-03
4	PL	alternative TSS	XM_063268798.1	0.03	0.02	1.1e-03	0.03	0.02	0.02	0.02	6.6e-04	2.5e-03	1.8e-03	2.0e-03
5	Liver	gene expression	Lasp1	0.07	0.05	3.2e-08	0.06	0.06	0.05	0.06	2.5e-07	5.2e-07	1.2e-06	7.6e-07
6	Liver	isoform ratio	XM_063268799.1	0.02	0.02	7.8e-03	0.01	0.01	0.02	0.01	7.3e-03	5.6e-02	5.8e-03	2.5e-02
7	OFC	isoform ratio	XM_063268798.1	0.78	0.16	8.5e-03	-0.01	0.06	0.04	0.1	6.4e-01	1.9e-02	4.2e-02	2.8e-03
8	OFC	alternative TSS	XM_063268798.1	0.85	0.12	1.8e-03	0.01	0.02	0.02	0.08	1.8e-01	1.1e-01	1.1e-01	5.8e-03
9	OFC	alternative TSS	XM_063268798.1	0.82	0.12	4.0e-03	0	0.01	0.01	0.06	2.6e-01	2.1e-01	1.7e-01	2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bone: apparent density	1.0	1.8	3.3	-1.8	-1.7	-1.6	-1.6	1.7	1.2	0.6	-0.1	0.0
Area under the delay curve	2.3	2.6	5.5	-0.8	-1.0	-0.9	-0.9	1.3	1.6	-2.3	-2.3	-2.3
BMI with tail	4.8	16.7	37.1	2.6	2.4	2.5	2.5	-2.4	-3.6	6.1	5.8	6.0
BMI without tail	1.2	3.8	5.7	2.4	2.2	2.1	2.1	-2.0	-1.9	1.1	1.7	1.6
Body weight	5.0	22.1	34.3	5.9	5.4	5.5	5.5	-5.6	-4.8	1.3	3.2	2.8
Weight adjusted by age	0.1	0.1	0.3	0.2	0.5	0.5	0.5	-0.4	-0.2	-0.5	-0.2	-0.3
Bone surface	0.0	0.0	0.1	0.1	0.0	0.0	0.0	-0.1	-0.1	0.1	0.3	0.2
Bone volume	0.0	0.1	0.1	-0.3	-0.2	-0.2	-0.2	0.2	0.1	0.3	0.2	0.2
Breakpoint value in progressive ratio session	1.2	1.4	2.7	1.6	1.3	1.5	1.5	-1.3	-0.8	-1.0	-0.2	-0.4
Number of licking bursts	0.3	0.6	0.9	-1.0	-1.0	-0.9	-0.9	0.7	0.9	0.0	-0.3	-0.3
Context. condit. distance diff. score	0.2	0.3	0.6	0.6	0.8	0.8	0.8	-0.5	-0.4	-0.2	0.1	0.0
Locomotion velocity, session 1	0.8	0.9	1.9	1.0	1.4	1.1	1.1	-1.2	-0.9	-0.2	0.4	0.3
Locomotion distance, session 1	2.5	3.2	5.9	2.4	2.2	2.3	2.3	-2.2	-1.6	-0.6	0.3	0.1
Locomotion velocity, session 2	0.5	0.6	1.2	0.9	1.0	1.0	1.0	-1.1	-0.6	-0.2	0.3	0.2
Locomotion distance, session 2	0.7	1.0	1.7	1.3	1.2	1.3	1.3	-1.3	-0.8	-0.3	0.2	0.1
Locomotion velocity, session 3	0.1	0.1	0.2	0.5	0.3	0.2	0.2	-0.4	-0.3	-0.1	0.0	0.0
Locomotion distance, session 3	0.3	0.3	0.7	0.7	0.8	0.6	0.6	-0.8	-0.6	-0.1	0.2	0.1
Stereotopy head waving bouts, day 3	2.4	2.8	5.0	-2.1	-2.2	-2.2	-2.2	2.0	1.3	0.4	-0.5	-0.3
Stereotopy head waving duration, day 3	0.4	0.5	1.0	-0.9	-1.0	-1.0	-1.0	0.8	0.5	0.0	-0.3	-0.2
Locomotion velocity, session 7	0.4	0.4	1.1	1.0	0.9	0.7	0.7	-0.7	-0.5	-0.3	0.0	-0.0
Locomotion distance, session 7	0.0	0.0	0.2	0.4	0.4	0.2	0.2	-0.1	-0.1	0.0	0.0	0.0
Stereotopy head waving bouts, day 7	0.8	0.9	2.0	-1.4	-1.2	-1.3	-1.3	1.0	0.3	0.2	-0.2	-0.1
Stereotopy head waving duration, day 7	0.2	0.2	0.6	-0.8	-0.6	-0.7	-0.7	0.3	-0.1	0.0	-0.1	-0.0
Locomotion velocity, session 8	4.0	4.8	8.3	2.9	2.8	2.8	2.8	-2.7	-1.9	-0.6	0.6	0.3
Locomotion distance, session 8	1.1	1.6	2.7	1.6	1.6	1.6	1.6	-1.6	-1.3	-0.4	0.3	0.2
Degree of sensitization distance	0.1	0.1	0.3	0.5	0.5	0.5	0.5	-0.2	-0.2	-0.1	0.0	0.0
Degree of sensitization stereotypy	1.1	1.2	2.5	-1.6	-1.3	-1.5	-1.5	1.2	0.5	0.3	-0.2	-0.1
Conditioned locomotion	0.1	0.2	0.3	-0.4	-0.5	-0.6	-0.6	0.5	0.3	0.1	-0.1	-0.1
Cocaine response after cond. corrected	1.1	1.4	3.2	-1.8	-1.4	-1.5	-1.5	1.3	1.1	0.4	-0.3	-0.1
Cocaine response after cond. not corrected	1.9	2.2	4.7	-2.2	-1.8	-1.9	-1.9	1.7	1.1	0.5	-0.2	-0.0
Cocaine response before conditioning	0.6	0.7	1.4	-0.8	-1.2	-1.2	-1.2	1.1	0.3	0.3	-0.1	0.0
Saline control response	0.1	0.1	0.1	-0.1	-0.4	-0.4	-0.4	0.3	0.3	0.1	0.0	0.0
Bone: connectivity density	1.6	2.4	4.1	-2.0	-2.0	-2.0	-2.0	2.0	1.3	0.6	-0.2	-0.0
Bone: cortical apparent density	2.7	3.7	7.3	-2.7	-2.3	-2.5	-2.5	2.4	1.0	1.0	0.0	0.2
Bone: cortical area	0.1	0.2	0.5	-0.6	-0.7	-0.6	-0.6	0.6	0.0	0.4	0.2	0.2
Bone: cortical porosity	0.6	0.7	1.1	-1.0	-1.0	-0.9	-0.9	1.0	1.1	0.1	-0.5	-0.4
Bone: cortical porosity	0.6	0.6	1.3	-0.9	-0.9	-0.8	-0.8	1.1	1.1	0.1	-0.5	-0.3
Bone: cortical thickness	0.8	1.4	3.1	-1.7	-1.5	-1.5	-1.5	1.4	0.6	0.6	0.0	0.2
Bone: cortical thickness	3.0	3.6	6.1	-2.4	-2.5	-2.4	-2.4	2.4	1.7	0.7	-0.4	-0.1
Bone: cortical tissue density	2.7	3.7	7.2	-2.7	-2.3	-2.5	-2.5	2.4	1.0	1.0	0.0	0.2
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	-0.6	-0.7	-0.6	-0.6	0.7	0.4	0.1	-0.2	-0.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.1	-0.7	-0.9	-0.8	-0.8	1.1	0.7	0.1	-0.3	-0.2
Condit. Reinf. active responses	0.3	0.4	0.7	-0.9	-0.8	-0.7	-0.7	0.8	0.6	0.2	-0.2	-0.1
Condit. Reinf. inactive responses	0.2	0.3	0.7	-0.8	-0.6	-0.6	-0.6	0.7	0.6	0.3	-0.0	0.0
Incentive salience index mean	0.7	0.9	1.7	-1.2	-1.3	-1.1	-1.1	1.3	0.8	0.2	-0.3	-0.2
Condit. Reinf. lever presses	0.7	1.0	1.9	-1.2	-1.3	-1.1	-1.1	1.4	1.0	0.3	-0.3	-0.1
Condit. Reinf. active minus inactive responses	0.5	0.7	1.1	-0.9	-1.1	-1.0	-1.0	0.8	1.0	-0.0	-0.5	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.7	-0.6	-0.6	-0.6	0.5	0.5	-0.0	-0.3	-0.2
Condit. Reinf. active responses	0.8	1.1	2.0	-1.1	-1.4	-1.4	-1.4	1.2	1.3	0.1	-0.4	-0.3
Condit. Reinf. inactive responses	1.3	1.7	2.9	-1.4	-1.7	-1.7	-1.7	1.7	1.4	0.4	-0.3	-0.2
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.1	-0.4	-0.4	-0.4	0.1	0.6	-0.2	-0.3	-0.3
Condit. Reinf. lever reinforcers received	0.8	1.1	1.9	-1.0	-1.4	-1.3	-1.3	1.1	1.3	0.1	-0.4	-0.3
Conditioned reinforcement - actives	0.7	1.2	1.8	-0.7	-1.1	-1.2	-1.2	1.3	1.2	-0.7	-1.1	-1.0
Conditioned reinforcement - inactives	0.2	0.3	0.7	0.1	-0.2	-0.1	-0.1	0.4	0.6	-0.7	-0.9	-0.8
Conditioned locomotion	0.9	1.2	2.3	-1.4	-1.3	-1.2	-1.2	1.5	1.3	0.5	-0.2	-0.0
Patch foraging indifference point 0 sec	0.9	1.6	2.8	-1.4	-1.6	-1.7	-1.7	1.4	1.6	0.2	-0.4	-0.3
Patch foraging indifference point AUC	0.1	0.1	0.5	-0.0	0.3	0.3	0.3	-0.4	-0.7	0.1	0.3	0.3
Delay disc. indifference point, 0s delay	2.8	3.0	4.8	-1.6	-1.2	-1.3	-1.3	1.5	2.1	-2.0	-2.2	-2.2
Delay disc. indifference point, 16s delay	0.8	0.8	1.3	-0.7	-0.8	-0.8	-0.8	0.9	0.8	-1.1	-1.1	-1.1
Delay disc. indifference point, 2s delay	3.7	4.1	6.5	-1.5	-1.5	-1.5	-1.5	1.8	2.4	-2.3	-2.6	-2.6
Delay disc. indifference point, 24s delay	0.1	0.2	0.5	-0.1	-0.3	-0.2	-0.2	0.1	-0.4	-0.7	-0.5	-0.5
Delay disc. indifference point, 4s delay	3.9	4.1	12.1	-0.8	-0.4	-0.4	-0.4	0.7	1.9	-3.5	-3.1	-3.2
Delay disc. indifference point, 8s delay	1.0	1.2	2.4	-0.5	-0.7	-0.7	-0.7	1.2	1.1	-1.4	-1.6	-1.5
Indifference point function ln k	0.0	0.1	0.1	-0.1	-0.3	-0.3	-0.3	0.2	0.4	-0.2	-0.3	-0.3
Indifference point function log k	0.0	0.1	0.1	-0.1	-0.3	-0.3	-0.3	0.2	0.4	-0.2	-0.3	-0.3
Patch foraging total patch changes 0 sec	0.5	1.0	1.7	-1.1	-1.2	-1.3	-1.3	1.1	1.3	0.1	-0.3	-0.2
Patch foraging total patch changes 12 sec	2.4	3.2	5.2	-2.3	-2.2	-2.3	-2.3	2.1	1.7	0.7	-0.2	-0.0
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.6	-0.5	-0.3	-0.3	0.1	0.5	0.1	0.1	0.1
Patch foraging total patch changes 24 sec	0.5	0.9	2.6	-1.6	-1.2	-1.1	-1.1	1.0	0.9	0.3	-0.2	-0.1
Patch foraging total patch changes 6 sec	0.5	0.7	1.7	-1.3	-1.1	-1.1	-1.1	0.8	0.7	0.3	-0.1	0.0
Patch foraging time to switch 0 sec	0.0	0.0	0.3	-0.1	-0.1	-0.0	-0.0	0.2	0.6	-0.0	-0.2	-0.2
Patch foraging water rate 0 sec	0.0	0.0	0.2	-0.0	-0.2	-0.3	-0.3	0.1	-0.4	0.1	0.1	0.1
Patch foraging water rate 12 sec	0.1	0.3	0.5	0.6	0.7	0.7	0.7	-0.7	-0.7	-0.3	0.1	-0.0
Patch foraging water rate 18 sec	0.3	0.5	1.2	-0.8	-0.8	-0.8	-0.8	1.1	0.6	0.1	-0.4	-0.2
Patch foraging water rate 24 sec	0.2	0.2	0.5	-0.4	-0.7	-0.7	-0.7	0.7	0.4	0.2	-0.1	-0.0
Patch foraging water rate 6 sec	0.5	0.7	1.4	-1.0	-1.2	-1.1	-1.1	1.1	0.4	0.4	-0.1	0.0
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	2.2	0.4	0.5	0.5	0.5	-0.5	-0.9	1.5	1.5	1.5
Distance traveled before self-admin	0.1	0.1	0.4	0.6	0.5	0.4	0.4	-0.1	0.1	-0.4	-0.2	-0.3
Distance traveled after self-admin	0.6	0.8	1.8	1.3	0.7	0.8	0.8	-0.6	-1.1	0.7	0.9	0.8
Extensor digitorum longus weight	5.1	20.2	33.1	5.7	5.7	5.7	5.7	-5.8	-4.0	-1.4	1.1	0.5
Bone: elastic displacement	0.0	0.0	0.1	-0.2	-0.0	-0.2	-0.2	0.0	0.3	-0.1	-0.2	-0.2
Bone: elastic work	0.0	0.0	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.0	-0.0	0.0
Bone: endosteal estimation	1.0	2.2	4.9	2.2	1.8	1.8	1.8	-1.8	-1.1	-0.5	0.3	0.1
Bone: endosteal perimeter	1.0	2.2	4.9	2.2	1.8	1.9	1.9	-1.8	-1.1	-0.4	0.4	0.2
Epididymis fat weight	0.0	0.1	0.3	0.6	0.2	0.2	0.2	-0.3	-0.2	-0.3	-0.1	-0.1
Delta time in closed arm before/after self-admin	2.9	2.7	3.8	1.9	1.7	1.8	1.8	-1.9	-1.8	0.8	1.4	1.3
Delta time in open arm before/after self-admin	0.1	0.1	0.4	-0.1	0.1	0.1	0.1	0.0	0.3	-0.6	-0.6	-0.6
Diff in mean of infusions in LGA sessions	0.1	0.1	0.6	0.8	0.2	0.2	0.2	-0.1	0.0	0.1	0.2	0.2
Delay discount exponential model param	2.1	2.3	5.5	0.6	0.7	0.7	0.7	-1.0	-1.4	2.4	2.3	2.3
Extinction: sum of active levers before priming	0.4	0.5	1.0	0.8	0.5	0.5	0.5	-0.6	-0.9	-1.0	-0.5	-0.6
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.1	-0.2	-0.2	-0.2	0.1	-0.5	0.3	0.3	0.3
Bone: final force	0.8	1.2	2.1	-1.3	-1.5	-1.4	-1.4	1.4	0.8	0.5	-0.1	0.0
Bone: final moment	0.7	1.1	1.8	-1.2	-1.4	-1.3	-1.3	1.3	0.9	0.5	-0.1	-0.0
Food consumed during 24 hour testing period	0.5	0.6	1.6	1.0	0.8	0.8	0.8	-1.3	-1.0	-0.4	0.1	-0.0
Glucose	0.7	1.2	2.1	-1.0	-0.8	-0.9	-0.9	0.8	0.8	-1.4	-1.4	-1.4
Heart weight	3.3	5.1	5.7	2.3	2.3	2.4	2.4	-2.3	-2.4	1.8	2.3	2.2
Delay discount hyperbolic model param	2.1	2.4	5.8	0.5	0.7	0.6	0.6	-1.0	-1.4	2.4	2.3	2.3
Intermittent access intake day 1-15 change	0.2	0.5	1.2	0.7	0.3	0.3	0.3	-0.1	-0.7	1.1	0.9	1.0
Intermittent access intake escalation	0.2	0.5	1.4	0.7	0.2	0.2	0.2	-0.1	-0.7	1.2	1.0	1.1
Intermittent access intake escalation 2	1.8	2.0	4.1	0.9	0.7	0.8	0.8	-0.8	-1.6	2.0	2.0	2.0
Intermitt. access day 1 inactive lever presses	0.2	0.8	1.5	-0.4	-0.7	-0.6	-0.6	0.9	1.1	-1.0	-1.2	-1.2
Intermitt. access day 15 inactive lever presses	0.3	0.6	1.2	-1.1	-0.7	-0.7	-0.7	0.8	0.4	1.1	0.6	0.7
Intermitt. access escalation Index	0.6	0.8	1.8	1.0	1.0	0.9	0.9	-1.4	-0.8	0.3	0.8	0.6
Intermittent access day 1 total infusions	0.1	0.1	0.4	0.1	0.0	-0.1	-0.1	0.2	0.1	-0.6	-0.6	-0.6
Intermittent access day 15 total infusions	0.1	0.1	0.5	0.7	0.2	0.1	0.1	-0.0	-0.5	0.2	0.1	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	0.3	-0.2	-0.2	-0.2	0.3	-0.4	0.6	0.4	0.5
Intermittent access total infusions	0.1	0.1	0.3	0.5	0.3	0.2	0.2	-0.1	-0.4	-0.3	-0.2	-0.2
Intermittent access day 1 locomotion	0.4	0.5	1.1	-0.3	-0.4	-0.4	-0.4	0.5	0.8	-1.0	-1.0	-1.0
Intermittent access day 15 total locomotion	0.3	0.6	1.3	-0.7	-1.0	-1.0	-1.0	1.1	0.4	-0.2	-0.6	-0.5
Intermittent access total locomotion	0.9	1.1	1.8	-1.1	-1.2	-1.1	-1.1	1.4	1.1	-0.4	-0.9	-0.8
Intermittent access standard deviation	0.1	0.2	0.7	-0.0	-0.3	-0.2	-0.2	0.4	-0.2	0.8	0.6	0.6
Left kidney weight	0.7	3.4	6.1	2.3	2.3	2.2	2.2	-2.5	-1.6	-1.2	-0.0	-0.3
Right kidney weight	0.1	0.5	1.1	0.7	0.7	0.6	0.6	-1.0	-0.4	-1.0	-0.5	-0.6
Cocaine induced anxiety	3.2	4.5	5.7	2.3	2.1	2.1	2.1	-2.1	-2.4	1.6	2.1	2.0
Post-drug Anxiety	1.3	1.4	2.1	1.2	0.9	0.9	0.9	-0.8	-1.1	1.4	1.5	1.5
Baseline Anxiety	2.8	3.3	4.7	-2.2	-2.0	-2.0	-2.0	1.9	2.1	-0.9	-1.5	-1.4
Tail length	3.6	14.0	47.5	2.5	2.6	2.5	2.5	-2.5	-0.2	-6.9	-4.5	-5.1
Length with tail	3.4	14.6	21.3	4.6	4.4	4.3	4.3	-4.6	-2.4	-4.4	-1.7	-2.3
Length without tail	2.2	7.0	12.0	3.2	3.1	3.1	3.1	-3.5	-2.6	0.4	1.6	1.3
Times rat made contact with spout	0.6	0.7	1.5	-1.2	-1.2	-1.1	-1.1	0.7	0.7	0.0	-0.3	-0.2
Lifetime Intake	0.0	0.1	0.1	0.4	0.1	0.0	0.0	0.0	-0.2	-0.4	-0.3	-0.3
Liver weight, left	0.1	0.2	0.4	0.5	0.6	0.6	0.6	-0.5	-0.7	-0.2	0.1	0.1
Liver weight, right	0.7	1.3	3.3	-0.7	-0.6	-0.6	-0.6	0.6	0.7	-1.8	-1.7	-1.7
Locomotor activity	0.4	0.6	1.1	-1.0	-1.0	-1.0	-1.0	0.9	0.6	0.2	-0.1	-0.1
Locomotor testing distance	1.8	3.2	5.9	-2.1	-2.4	-2.2	-2.2	2.3	1.6	0.6	-0.3	-0.1
Locomotor testing rearing	2.3	4.6	8.3	-2.8	-2.9	-2.7	-2.7	2.7	1.6	0.7	-0.4	-0.2
Locomotion in novel chamber	3.6	4.5	7.5	-2.7	-1.8	-1.8	-1.8	1.6	1.8	-2.3	-2.5	-2.5
Locomotion in novel chamber post-restriction	0.3	0.5	1.6	-0.4	-0.6	-0.6	-0.6	0.2	0.2	1.3	0.8	0.9
Fecal boli incidents, locomotor time 1	1.2	1.7	4.4	0.4	0.7	0.7	0.7	-0.5	-1.3	2.1	1.9	2.0
Change in fecal boli incidents, locomotor task	1.4	1.4	2.9	-0.6	-0.8	-0.8	-0.8	0.8	1.1	-1.7	-1.7	-1.7
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.2	-0.9	-0.7	-0.7	-0.7	0.8	0.8	-0.8	-1.1	-1.0
Bouts of movement, locomotor time 1	0.3	0.4	0.9	0.8	0.9	0.9	0.9	-0.5	-0.1	-0.3	-0.1	-0.1
Total resting periods, locomotor time 1	0.4	0.5	1.0	0.9	1.0	1.0	1.0	-0.6	-0.0	-0.3	-0.1	-0.1
Rest time, locomotor task time 1	0.1	0.2	0.4	0.2	0.3	0.3	0.3	-0.3	0.7	-0.5	-0.5	-0.5
Distance moved, locomotor task time 1	0.2	0.4	0.7	-0.2	-0.6	-0.6	-0.6	0.5	0.4	-0.8	-0.8	-0.8
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.4	0.2	0.1	0.1	-0.0	-0.5	-0.0	0.1	0.1
Time >=10cm from walls, locomotor time 2	1.7	2.5	4.5	-1.5	-1.1	-1.0	-1.0	1.3	1.7	-1.8	-2.1	-2.1
Bouts of movement, locomotor time 2	0.1	0.1	0.4	-0.4	-0.1	-0.0	-0.0	0.6	0.4	0.1	-0.1	-0.1
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.1	0.2	0.2	0.2	0.4	0.3	0.3	0.1	0.1
Rest time, locomotor task time 2	0.9	1.2	2.3	1.1	1.4	1.5	1.5	-1.0	-0.5	0.6	0.8	0.8
Distance moved, locomotor task time 2	0.4	0.5	2.0	-0.0	-0.1	-0.1	-0.1	-0.1	0.2	-1.4	-1.1	-1.2
Vertical activity count, locomotor time 2	0.4	0.5	2.0	0.3	0.0	-0.0	-0.0	-0.1	0.2	-1.4	-1.2	-1.2
Light reinforcement 1	0.8	1.9	3.3	-1.4	-1.7	-1.8	-1.8	1.6	1.6	0.5	-0.4	-0.2
Light reinforcement 2	0.3	0.5	1.0	-0.7	-1.0	-1.0	-1.0	0.8	0.6	0.3	-0.2	-0.1
Bone: marrow area	1.0	2.1	4.7	2.2	1.8	1.8	1.8	-1.8	-1.1	-0.5	0.3	0.1
Bone: maximum diameter	0.0	0.0	0.1	0.0	-0.2	-0.1	-0.1	0.1	-0.0	0.2	0.2	0.2
Bone: maximum force	0.0	0.0	0.1	-0.1	-0.3	-0.3	-0.3	0.2	-0.1	0.2	0.1	0.1
Bone: maximum moment	0.0	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.2	-0.0	0.2	0.1	0.1
Mean time between licks in bursts	0.7	1.8	3.7	1.6	1.7	1.9	1.9	-1.6	-0.7	-0.4	0.2	0.1
Mean num. licks in bursts	0.0	0.0	0.0	0.0	-0.0	0.1	0.1	0.0	-0.2	0.1	0.0	0.1
Cd content in liver	0.6	0.6	1.7	1.3	0.9	1.1	1.1	-0.6	-0.6	-0.1	0.2	0.2
Co content in liver	1.4	1.6	2.9	1.7	1.6	1.6	1.6	-1.5	-1.3	-0.2	0.5	0.3
Cu content in liver	0.6	0.7	1.3	0.9	1.1	1.1	1.1	-1.1	-0.4	-0.0	0.4	0.3
Fe content in liver	1.4	1.7	2.8	1.6	1.6	1.6	1.6	-1.7	-1.2	-0.3	0.4	0.3
K content in liver	0.0	0.0	0.1	-0.3	0.1	0.3	0.3	-0.1	-0.0	-0.1	-0.1	-0.1
Mg content in liver	0.0	0.0	0.2	-0.5	-0.0	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.0
Mn content in liver	0.0	0.0	0.1	-0.3	-0.2	0.1	0.1	0.2	0.1	0.1	0.0	0.0
Na content in liver	0.1	0.1	0.6	-0.5	-0.3	-0.2	-0.2	0.1	0.8	0.1	-0.1	-0.1
Rb content in liver	0.9	1.0	1.6	-1.3	-1.2	-1.1	-1.1	1.3	1.2	0.2	-0.4	-0.2
Se content in liver	1.7	2.0	4.3	-2.1	-1.8	-1.7	-1.7	1.7	1.2	0.5	-0.3	-0.1
Sr content in liver	0.7	0.6	1.0	1.0	1.0	1.0	1.0	-1.0	-0.8	-0.2	0.2	0.1
Zn content in liver	0.9	1.0	1.9	-1.4	-1.2	-1.1	-1.1	1.3	1.2	0.4	-0.2	-0.0
Bone: minimum diameter	0.3	0.5	1.1	1.1	0.6	0.7	0.7	-0.8	-1.0	0.0	0.4	0.3
Time in familiar zone, hab. session 1	0.4	0.4	0.8	-0.6	-0.9	-0.8	-0.8	0.7	0.2	-0.0	-0.3	-0.3
Time in novel zone, hab. session 1	0.5	0.5	0.9	-0.9	-0.6	-0.8	-0.8	0.8	0.9	0.3	-0.0	0.0
Total zone transitions, hab. session 1	1.5	2.1	3.4	1.8	1.8	1.8	1.8	-1.8	-1.4	-0.6	0.2	-0.0
Total locomotion distance, hab. session 1	0.0	0.0	0.1	0.3	0.0	0.1	0.1	-0.1	0.2	-0.1	-0.1	-0.1
Locomotion velocity, hab. session 1	0.3	0.4	1.1	1.0	0.7	0.8	0.8	-0.8	-0.3	-0.3	0.1	-0.0
Time in familiar zone, hab. session 2	0.5	0.5	0.9	-0.6	-0.8	-0.9	-0.9	0.9	0.8	0.1	-0.3	-0.2
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.2	-0.1	-0.0	-0.0	0.1	0.0	0.1	0.0	0.1
Total zone transitions, hab. session 2	0.4	0.5	1.0	1.0	0.8	1.0	1.0	-0.8	-0.6	-0.3	0.1	-0.0
Total locomotion distance, hab. session 2	0.0	0.1	0.3	0.5	0.1	0.3	0.3	-0.2	-0.1	-0.1	-0.0	-0.1
Locomotion velocity, hab. session 2	0.1	0.2	0.6	0.8	0.3	0.5	0.5	-0.4	-0.3	-0.1	0.0	-0.0
Novel to familiar place preference ratio	0.9	1.0	1.9	1.1	1.3	1.1	1.1	-1.4	-1.1	-0.4	0.2	0.1
Novelty place preference	0.5	0.6	1.1	0.9	1.0	0.8	0.8	-1.0	-0.8	-0.3	0.2	0.1
Time in novel zone, NPP test	0.1	0.1	0.3	0.3	0.5	0.4	0.4	-0.6	-0.5	-0.2	0.0	-0.0
Total zone transitions, NPP test	0.2	0.3	0.6	0.8	0.5	0.6	0.6	-0.6	-0.5	-0.3	-0.0	-0.1
Total locomotion distance, NPP test	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1	0.0	0.3	-0.1	-0.1	-0.1
Locomotion velocity, NPP test	0.1	0.2	0.5	0.7	0.5	0.5	0.5	-0.6	-0.2	-0.2	0.0	-0.0
Intraocular pressure	0.8	1.2	2.2	1.5	1.2	1.3	1.3	-1.1	-1.4	-0.4	0.3	0.1
Delta distance traveled before/after self-admin	0.9	0.9	1.7	0.9	0.5	0.7	0.7	-0.7	-1.3	1.1	1.2	1.2
Delta ambulatory time before/after self-admin	0.3	0.3	0.7	0.7	0.1	0.3	0.3	-0.4	-0.8	0.7	0.8	0.8
Parametrial fat weight	0.7	1.6	2.3	-0.8	-1.2	-1.3	-1.3	1.3	1.5	-1.2	-1.4	-1.4
Pavlov. Cond. lever latency	1.7	2.1	4.0	1.8	2.0	1.8	1.8	-1.9	-1.3	-0.5	0.3	0.1
Pavlov. Cond. magazine entry latency	6.2	7.9	13.4	-3.6	-3.7	-3.6	-3.6	3.5	2.4	1.1	-0.4	-0.1
Pavlov. Cond. change in total contacts	5.5	5.9	10.3	-3.2	-3.1	-3.2	-3.2	2.9	1.6	0.8	-0.4	-0.1
Pavlov. Cond. index score	5.9	7.4	12.9	-3.4	-3.6	-3.5	-3.5	3.4	2.3	1.0	-0.5	-0.1
Pavlov. Cond. latency score	4.6	5.8	10.2	-3.0	-3.2	-3.1	-3.1	3.0	2.0	0.8	-0.4	-0.1
Pavlov. Cond. lever contacts	2.2	2.6	4.6	-2.0	-2.1	-2.0	-2.0	2.0	1.5	0.6	-0.3	-0.1
Pavlov. Cond. magazine entry number	8.8	11.1	18.7	4.3	4.3	4.3	4.3	-4.1	-2.6	-1.1	0.6	0.2
Pavlov. Cond. intertrial magazine entries	1.1	1.3	2.4	1.3	1.4	1.5	1.5	-1.4	-1.0	-0.4	0.2	0.0
Pavlov. Cond. lever-magazine prob. diff.	6.9	8.5	14.7	-3.7	-3.8	-3.8	-3.8	3.6	2.4	1.0	-0.5	-0.1
Pavlov. Cond. response bias	6.7	8.3	14.2	-3.6	-3.8	-3.7	-3.7	3.6	2.4	1.0	-0.5	-0.2
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.6	0.8	0.8	0.8	-0.4	-0.6	-0.0	0.2	0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.0	0.1	0.1	0.1	-0.3	0.0	-0.1	0.0	-0.0
Pavlov. Cond. change in total contacts	0.3	0.4	0.8	-0.7	-0.8	-0.9	-0.9	0.7	0.7	0.1	-0.3	-0.2
Pavlov. Cond. index score	0.1	0.2	0.4	-0.5	-0.6	-0.6	-0.6	0.2	0.4	-0.0	-0.2	-0.1
Pavlov. Cond. latency score	0.1	0.2	0.4	-0.4	-0.6	-0.6	-0.6	0.2	0.4	-0.0	-0.1	-0.1
Pavlov. Cond. lever contacts	0.4	0.5	1.1	-0.8	-1.0	-1.0	-1.0	0.7	0.8	0.1	-0.2	-0.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.5	0.5	0.5	0.5	-0.3	-0.5	-0.1	0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.9	1.3	2.3	1.5	1.5	1.5	1.5	-1.4	-1.0	-0.3	0.3	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.4	0.1	0.4	-0.1	-0.1	-0.1
Pavlov. Cond. response bias	0.5	0.7	1.2	-1.1	-1.1	-1.1	-1.1	0.8	0.9	0.2	-0.2	-0.2
Time in closed arm before self-admin	1.1	1.5	2.6	-1.3	-1.6	-1.5	-1.5	1.4	1.4	0.3	-0.3	-0.2
Time in closed arm after self-admin	0.4	0.4	0.8	0.6	0.3	0.4	0.4	-0.7	-0.6	0.8	0.9	0.9
Time in open arm before self-admin	2.5	2.7	3.4	1.6	1.9	1.8	1.8	-1.7	-1.7	1.1	1.6	1.5
Time in open arm after self-admin	0.4	0.4	0.9	0.6	0.9	0.9	0.9	-0.7	-0.5	-0.1	0.2	0.1
Bone: periosteal estimation	0.1	0.2	0.4	0.7	0.4	0.4	0.4	-0.4	-0.4	0.0	0.2	0.2
Bone: periosteal perimeter	0.4	0.6	1.4	1.2	0.8	1.0	1.0	-0.9	-0.7	-0.0	0.4	0.3
Bone: post-yield work	0.4	0.5	1.3	1.1	0.9	1.0	1.0	-0.8	-0.3	-0.3	0.1	0.0
Progressive ratio test 1 active lever presses	1.1	1.3	2.7	-0.5	-0.8	-0.9	-0.9	0.9	1.0	-1.6	-1.6	-1.6
Progressive ratio test 1 breakpoint	1.0	1.2	2.4	-0.4	-0.8	-0.9	-0.9	0.9	1.0	-1.5	-1.5	-1.5
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.7	0.1	-0.3	-0.3	-0.3	0.4	0.6	-0.7	-0.8	-0.8
Progressive ratio test 2 active lever presses	0.5	0.6	1.1	-0.7	-0.7	-0.8	-0.8	0.8	0.5	-0.9	-1.0	-1.0
Progressive ratio test 2 breakpoint	0.7	0.8	1.4	-0.7	-0.7	-0.8	-0.8	0.8	0.5	-1.0	-1.2	-1.1
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	0.3	0.6	0.5	0.5	-0.3	-0.6	-0.3	-0.1	-0.1
Incentive Sensitization - Responses	0.3	0.5	0.9	-0.9	-0.7	-0.7	-0.7	0.7	0.5	-0.5	-0.7	-0.7
Incentive Sensitization - Breakpoint	0.3	0.3	0.7	-0.9	-0.5	-0.6	-0.6	0.6	0.3	-0.4	-0.6	-0.6
Sum of active levers in priming session hrs 5-6	1.0	0.9	3.0	-0.3	-0.4	-0.4	-0.4	0.4	-0.0	-1.7	-1.5	-1.5
Progressive ratio	0.0	0.0	0.1	0.1	-0.0	0.0	0.0	-0.1	0.3	-0.0	0.1	0.0
Food seeking constrained by brief footshock	0.3	0.3	0.6	-0.6	-0.7	-0.7	-0.7	0.8	0.5	0.1	-0.2	-0.1
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	-0.6	-0.4	-0.4	-0.4	0.5	-0.1	-0.2	-0.4	-0.4
Retroperitoneal fat weight	0.2	1.0	2.0	-0.4	-0.9	-0.9	-0.9	1.0	1.4	-1.0	-1.2	-1.2
Reaction time number correct	0.3	0.7	1.2	1.0	1.0	1.1	1.1	-1.1	-0.4	-0.2	0.2	0.1
Reaction time mean minus median	0.0	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	-0.1	0.2	0.2	0.2
Reaction time mean minus median AUC	0.1	0.3	0.6	-0.7	-0.7	-0.6	-0.6	0.7	0.7	0.4	0.0	0.1
Reaction time num false alarms	0.4	0.6	1.0	-0.9	-1.0	-1.0	-1.0	1.0	0.4	-0.0	-0.4	-0.3
Reaction time num false alarms AUC	0.3	0.4	0.8	-0.8	-0.8	-0.9	-0.9	0.8	0.4	-0.1	-0.4	-0.3
Reaction time trials correct on left	0.3	0.7	1.2	1.0	1.0	1.1	1.1	-1.1	-0.4	-0.2	0.2	0.1
Reaction time trials on left	0.3	0.6	1.1	1.0	0.9	1.0	1.0	-1.0	-0.4	-0.2	0.2	0.1
Reaction time mean	0.0	0.0	0.1	-0.3	0.0	0.0	0.0	0.0	0.2	0.2	0.2	0.2
Reaction time mean AUC	0.0	0.0	0.1	-0.3	0.2	0.1	0.1	-0.0	0.1	0.2	0.2	0.2
Median of all reaction times	0.1	0.1	0.6	-0.8	-0.3	-0.3	-0.3	0.3	0.4	0.2	0.1	0.1
Reaction time omissions	0.2	0.3	0.7	-0.6	-0.7	-0.8	-0.8	0.7	0.4	0.3	-0.0	0.0
Reaction time false alarm rate	0.8	1.1	1.9	-1.2	-1.3	-1.4	-1.4	1.3	0.7	0.0	-0.5	-0.4
Reaction time premature initiation rate	0.2	0.3	0.7	-0.4	-0.8	-0.7	-0.7	0.5	0.6	0.3	-0.0	0.0
Reaction time premature initiations	0.0	0.0	0.2	0.4	0.0	0.2	0.2	-0.3	0.2	0.1	0.1	0.1
Std. dev. reaction times	0.0	0.1	0.1	-0.3	-0.2	-0.2	-0.2	0.2	0.2	0.3	0.2	0.2
Reaction time trials completed	0.3	0.6	1.1	1.0	0.9	1.0	1.0	-1.0	-0.4	-0.2	0.2	0.1
Reaction time trials AUC	0.3	0.5	1.0	0.9	0.9	1.0	1.0	-1.0	-0.3	-0.2	0.1	0.0
Run reversals in cocaine runway, females	0.8	0.8	1.6	1.3	1.1	1.1	1.1	-1.0	-1.0	-0.3	0.1	0.0
Run reversals in cocaine runway, males	0.9	0.9	3.3	-0.7	-0.5	-0.5	-0.5	0.5	-0.2	1.8	1.2	1.4
Latency to leave start box in cocaine runway	3.7	4.2	5.7	1.8	2.0	2.0	2.0	-1.8	-2.0	2.2	2.4	2.4
Latency to leave start box in cocaine runway, F	4.0	4.6	6.4	1.9	2.0	2.0	2.0	-2.1	-1.8	2.2	2.5	2.5
Latency to leave start box in cocaine runway, M	0.7	0.6	1.3	0.4	0.8	0.8	0.8	-0.6	-1.1	0.8	0.8	0.9
Std. dev. time between licks in bursts	0.2	0.2	0.5	0.5	0.7	0.6	0.6	-0.7	-0.4	-0.1	0.2	0.1
Total sessions with >9 infusions	0.1	0.1	0.3	0.1	-0.2	-0.3	-0.3	0.3	0.2	-0.6	-0.6	-0.6
Short access day 1 total inactive lever presses	1.8	2.4	4.6	-0.8	-1.0	-1.1	-1.1	1.2	1.6	-2.0	-2.1	-2.1
Short access day 10 total inactive lever presses	0.8	1.9	4.5	1.1	0.8	0.9	0.9	-0.8	-0.9	2.1	1.9	2.0
Short access day 1 total infusions	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.1	0.2	-0.0	-0.1	-0.1	-0.1
Short access day 10 total infusions	0.1	0.1	0.3	-0.4	-0.4	-0.5	-0.5	0.6	-0.2	-0.0	-0.2	-0.2
Short access total infusions	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1
Short access day 1 locomotion	0.4	0.5	0.7	-0.8	-0.9	-0.9	-0.9	0.9	0.6	-0.2	-0.5	-0.4
Short access day 10 total locomotion	1.3	2.4	4.4	-1.8	-2.1	-1.9	-1.9	2.0	1.5	0.3	-0.5	-0.4
Short access total locomotion	0.2	0.2	0.4	-0.4	-0.6	-0.6	-0.6	0.6	0.6	0.2	-0.1	-0.0
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.4	-0.1	-0.2	-0.2	0.3	0.2	-0.5	-0.5	-0.5
Compulsive drug intake	1.4	1.6	4.4	-0.2	-0.4	-0.5	-0.5	0.4	1.4	-2.1	-1.8	-2.0
One hour access (shock baseline)	0.3	0.5	1.3	0.6	0.2	0.2	0.2	-0.1	-0.9	1.1	0.9	1.0
Social response proportion	0.0	0.0	0.1	-0.0	0.2	0.0	0.0	0.2	0.3	0.0	-0.1	-0.1
Social responses	0.0	0.0	0.1	-0.2	-0.1	-0.3	-0.3	0.4	0.2	0.1	-0.1	-0.1
Social time	0.0	0.0	0.1	0.1	0.1	-0.0	-0.0	-0.1	-0.3	0.1	0.1	0.1
Soleus weight	0.3	1.0	1.8	-1.3	-1.2	-1.3	-1.3	1.1	0.9	0.4	-0.1	0.0
Bone: stiffness	0.0	0.1	0.2	-0.1	-0.3	-0.3	-0.3	0.3	0.1	0.4	0.3	0.3
Tibialis anterior weight	0.8	2.7	5.2	1.9	2.1	2.1	2.1	-2.3	-1.5	-0.5	0.5	0.2
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.6	-0.4	-0.6	-0.7	-0.7	0.8	0.7	-1.3	-1.2	-1.2
Time to tail flick, vehicle, after self-admin	0.3	0.5	1.1	-0.4	-0.6	-0.5	-0.5	0.2	-0.3	1.1	0.9	1.0
Time to tail flick, test, before self-admin	0.5	0.6	1.0	0.7	0.5	0.3	0.3	-0.6	-1.0	0.9	1.0	1.0
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.4	-0.2	-0.3	-0.3	0.2	0.0	0.2	0.1	0.2
Delta time to tail flick, vehicle, before/after SA	0.7	0.6	1.9	-0.7	-0.7	-0.6	-0.6	0.4	0.1	1.4	0.9	1.0
Delta time to tail flick, test, before/after SA	2.4	2.5	3.8	-1.5	-1.3	-1.1	-1.1	1.3	1.8	-1.8	-2.0	-1.9
Tibia length	0.4	1.1	2.3	1.3	1.2	1.2	1.2	-1.5	-1.0	-0.3	0.4	0.3
Ambulatory time before self-admin	0.3	0.5	1.0	0.9	1.0	1.0	1.0	-0.6	-0.4	-0.0	0.2	0.1
Ambulatory time after self-admin	1.7	2.0	3.7	1.9	1.4	1.5	1.5	-1.3	-1.8	0.8	1.2	1.1
Bone: tissue strength	0.2	0.2	0.6	0.6	0.7	0.5	0.5	-0.8	-0.6	-0.1	0.2	0.1
Total heroin consumption	0.2	0.3	0.8	-0.9	-0.5	-0.4	-0.4	0.6	0.2	-0.4	-0.5	-0.5
Bone: trabecular number	3.2	5.2	8.6	-2.9	-2.9	-2.9	-2.9	2.9	2.0	0.9	-0.3	-0.0
Bone: trabecular spacing	0.6	0.8	1.5	1.2	1.1	1.1	1.1	-1.0	-0.8	-0.3	0.1	0.0
Bone: trabecular thickness	0.0	0.0	0.0	-0.2	-0.0	0.0	0.0	-0.0	0.0	0.1	0.1	0.1
Bone: trabecular tissue density	0.0	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	-0.1	-0.0	0.0	-0.0
Water consumed over 24 hours	0.0	0.0	0.0	0.0	-0.2	-0.2	-0.2	-0.2	0.1	-0.2	-0.2	-0.2
Number of responses in last shaping day	0.4	0.4	1.1	0.1	0.3	0.2	0.2	-0.5	-1.1	0.9	0.9	0.9