Hub : Genes

Lasp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Lasp1 0.02 0.02 2.8e-03 0.02 0.02 0.02 0.02 2.8e-03 4.8e-03 4.4e-03 4.9e-03
2 pVTA gene expression Lasp1 0.03 0.02 9.5e-03 0.02 0.01 0.01 0.01 1.1e-02 2.4e-02 2.3e-02 2.6e-02
3 PL isoform ratio XM_063268798.1 0.03 0.03 8.1e-03 0.01 0.01 0 0.01 1.2e-02 5.1e-02 2.0e-01 6.6e-02
4 PL alternative TSS XM_063268798.1 0.03 0.02 1.0e-03 0.03 0.02 0.02 0.02 6.7e-04 2.2e-03 2.1e-03 2.6e-03
5 PL alternative TSS XM_063268798.1 0.03 0.02 1.1e-03 0.03 0.02 0.02 0.02 6.6e-04 2.5e-03 1.8e-03 2.1e-03
6 Liver gene expression Lasp1 0.07 0.05 3.2e-08 0.06 0.06 0.05 0.06 2.5e-07 5.2e-07 1.2e-06 8.0e-07
7 Liver isoform ratio XM_063268799.1 0.02 0.02 7.8e-03 0.01 0.01 0.02 0.01 7.3e-03 5.6e-02 5.8e-03 2.3e-02
8 OFC isoform ratio XM_063268798.1 0.78 0.16 8.5e-03 0.05 0.05 0.15 0.15 2.5e-02 2.7e-02 2.6e-04 2.5e-04
9 OFC alternative TSS XM_063268798.1 0.85 0.12 1.8e-03 0.01 0.02 0.02 0.08 1.8e-01 1.1e-01 1.1e-01 6.0e-03
10 OFC alternative TSS XM_063268798.1 0.82 0.12 4.0e-03 0 0.01 0.01 0.06 2.6e-01 2.1e-01 1.7e-01 2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density1.01.93.31.8-1.71.71.61.6-1.7-1.20.0-0.10.0
Area under the delay curve1.42.15.50.8-1.01.00.90.9-1.3-1.6-1.2-2.3-2.3
BMI with tail3.813.335.5-2.62.5-2.4-2.5-2.52.43.63.75.86.0
BMI without tail0.73.85.7-2.42.2-2.2-2.1-2.12.01.9-0.61.71.6
Body weight5.523.934.3-5.95.6-5.4-5.5-5.55.64.8-3.23.22.8
Weight adjusted by age0.10.20.8-0.20.4-0.5-0.5-0.50.40.2-0.9-0.2-0.3
Bone surface0.00.00.1-0.10.0-0.0-0.0-0.00.10.10.00.30.2
Bone volume0.00.10.10.3-0.30.20.20.2-0.2-0.10.00.20.2
Breakpoint value in progressive ratio session1.01.83.9-1.61.6-1.3-1.5-1.51.30.8-2.0-0.2-0.4
Number of licking bursts0.20.60.91.0-0.91.00.90.9-0.7-0.90.0-0.3-0.3
Context. condit. distance diff. score0.30.30.6-0.60.8-0.8-0.8-0.80.50.40.00.10.0
Locomotion velocity, session 10.80.91.9-1.01.1-1.4-1.1-1.11.20.90.00.40.3
Locomotion distance, session 12.63.35.9-2.42.3-2.2-2.3-2.32.21.60.00.30.1
Locomotion velocity, session 20.50.61.2-0.90.9-1.0-1.0-1.01.10.60.00.30.2
Locomotion distance, session 20.71.01.7-1.31.3-1.2-1.3-1.31.30.80.00.20.1
Locomotion velocity, session 30.10.10.2-0.50.2-0.3-0.2-0.20.40.30.00.00.0
Locomotion distance, session 30.30.40.7-0.70.7-0.8-0.6-0.60.80.60.00.20.1
Stereotopy head waving bouts, day 32.52.95.02.1-2.12.22.22.2-2.0-1.30.0-0.5-0.3
Stereotopy head waving duration, day 30.50.61.00.9-1.01.01.01.0-0.8-0.50.0-0.3-0.2
Locomotion velocity, session 70.40.41.1-1.00.8-0.9-0.7-0.70.70.50.00.0-0.0
Locomotion distance, session 70.00.00.2-0.40.3-0.4-0.2-0.20.10.10.00.00.0
Stereotopy head waving bouts, day 70.81.02.01.4-1.31.21.31.3-1.0-0.30.0-0.2-0.1
Stereotopy head waving duration, day 70.20.20.60.8-0.70.60.70.7-0.30.10.0-0.1-0.0
Locomotion velocity, session 84.25.08.3-2.92.8-2.8-2.8-2.82.71.90.00.60.3
Locomotion distance, session 81.21.72.7-1.61.6-1.6-1.6-1.61.61.30.00.30.2
Degree of sensitization distance0.10.10.3-0.50.5-0.5-0.5-0.50.20.20.00.00.0
Degree of sensitization stereotypy1.11.22.51.6-1.51.31.51.5-1.2-0.50.0-0.2-0.1
Conditioned locomotion0.20.20.50.4-0.70.50.60.6-0.5-0.30.0-0.1-0.1
Cocaine response after cond. corrected1.01.53.21.8-1.51.41.51.5-1.3-1.10.0-0.3-0.1
Cocaine response after cond. not corrected1.62.44.72.2-2.01.81.91.9-1.7-1.10.0-0.2-0.0
Cocaine response before conditioning0.60.71.40.8-1.21.21.21.2-1.1-0.30.0-0.10.0
Saline control response0.10.10.10.1-0.40.40.40.4-0.3-0.30.00.00.0
Bone: connectivity density1.62.54.12.0-2.02.02.02.0-2.0-1.30.0-0.2-0.0
Bone: cortical apparent density2.53.97.32.7-2.62.32.52.5-2.4-1.00.00.00.2
Bone: cortical area0.10.20.50.6-0.60.70.60.6-0.6-0.00.00.20.2
Bone: cortical porosity0.60.71.11.0-0.91.00.90.9-1.0-1.10.0-0.5-0.4
Bone: cortical porosity0.60.71.30.9-0.90.90.80.8-1.1-1.10.0-0.5-0.3
Bone: cortical thickness0.91.43.11.7-1.51.51.51.5-1.4-0.60.00.00.2
Bone: cortical thickness3.13.76.12.4-2.42.52.42.4-2.4-1.70.0-0.4-0.1
Bone: cortical tissue density2.43.97.22.7-2.62.32.52.5-2.4-1.00.00.00.2
Condit. Reinf. active minus inactive responses0.20.30.50.6-0.60.70.60.6-0.7-0.40.0-0.2-0.1
Condit. Reinf. active-inactive response ratio0.50.51.10.7-0.80.90.80.8-1.1-0.70.0-0.3-0.2
Condit. Reinf. active responses0.30.40.70.9-0.80.80.70.7-0.8-0.60.0-0.2-0.1
Condit. Reinf. inactive responses0.20.30.70.8-0.60.60.60.6-0.7-0.60.0-0.00.0
Incentive salience index mean0.70.91.71.2-1.11.31.11.1-1.3-0.80.0-0.3-0.2
Condit. Reinf. lever presses0.71.01.91.2-1.11.31.11.1-1.4-1.00.0-0.3-0.1
Condit. Reinf. active minus inactive responses0.50.71.10.9-1.01.11.01.0-0.8-1.00.0-0.5-0.4
Condit. Reinf. active-inactive response ratio0.20.30.50.7-0.60.60.60.6-0.5-0.50.0-0.3-0.3
Condit. Reinf. active responses0.81.22.01.1-1.41.41.41.4-1.2-1.30.0-0.4-0.3
Condit. Reinf. inactive responses1.21.82.91.4-1.71.71.71.7-1.7-1.40.0-0.3-0.2
Condit. Reinf. lever presses0.10.10.30.1-0.40.40.40.4-0.1-0.60.0-0.3-0.3
Condit. Reinf. lever reinforcers received0.81.21.91.0-1.41.41.31.3-1.1-1.30.0-0.4-0.3
Conditioned reinforcement - actives0.31.21.80.7-1.11.11.21.2-1.3-1.20.5-1.1-1.0
Conditioned reinforcement - inactives0.10.20.7-0.1-0.10.20.10.1-0.4-0.6-0.2-0.9-0.8
Conditioned locomotion1.01.53.01.4-1.21.31.21.2-1.5-1.31.7-0.2-0.0
Patch foraging indifference point 0 sec0.61.72.81.4-1.51.61.71.7-1.4-1.60.0-0.4-0.3
Patch foraging indifference point AUC0.10.10.50.00.3-0.3-0.3-0.30.40.70.00.30.3
Delay disc. indifference point, 0s delay2.22.54.81.6-1.21.21.31.3-1.5-2.1-0.7-2.2-2.2
Delay disc. indifference point, 16s delay0.50.71.30.7-0.80.80.80.8-0.9-0.8-0.4-1.1-1.1
Delay disc. indifference point, 2s delay3.13.46.61.5-1.61.51.51.5-1.8-2.4-0.8-2.6-2.5
Delay disc. indifference point, 24s delay0.10.20.70.1-0.30.30.20.2-0.10.4-0.8-0.5-0.5
Delay disc. indifference point, 4s delay3.03.210.20.8-0.40.40.40.4-0.7-1.9-2.7-3.1-3.2
Delay disc. indifference point, 8s delay0.61.02.40.5-0.70.70.70.7-1.2-1.1-0.3-1.6-1.5
Indifference point function ln k0.00.10.10.1-0.40.30.30.3-0.2-0.40.0-0.3-0.3
Indifference point function log k0.00.10.10.1-0.40.30.30.3-0.2-0.40.0-0.3-0.3
Patch foraging total patch changes 0 sec0.41.11.71.1-1.21.21.31.3-1.1-1.30.0-0.3-0.2
Patch foraging total patch changes 12 sec2.53.35.22.3-2.22.22.32.3-2.1-1.70.0-0.2-0.0
Patch foraging total patch changes 18 sec0.10.10.30.6-0.40.50.30.3-0.1-0.50.00.10.1
Patch foraging total patch changes 24 sec0.30.92.61.6-1.11.21.11.1-1.0-0.90.0-0.2-0.1
Patch foraging total patch changes 6 sec0.40.71.71.3-1.01.11.11.1-0.8-0.70.0-0.10.0
Patch foraging time to switch 0 sec0.00.00.30.1-0.00.10.00.0-0.2-0.60.0-0.2-0.2
Patch foraging water rate 0 sec0.00.00.20.0-0.30.20.30.3-0.10.40.00.10.1
Patch foraging water rate 12 sec0.10.30.5-0.60.7-0.7-0.7-0.70.70.70.00.10.0
Patch foraging water rate 18 sec0.20.51.20.8-0.70.80.80.8-1.1-0.60.0-0.4-0.3
Patch foraging water rate 24 sec0.20.30.70.4-0.80.70.70.7-0.7-0.40.0-0.1-0.0
Patch foraging water rate 6 sec0.50.71.41.0-1.11.21.11.1-1.1-0.40.0-0.10.0
Seeking ratio, delayed vs. immediate footshock0.50.82.2-0.40.8-0.5-0.5-0.50.50.90.81.51.5
Distance traveled before self-admin0.10.20.5-0.60.7-0.5-0.4-0.40.1-0.1-0.4-0.2-0.3
Distance traveled after self-admin0.40.71.8-1.31.0-0.7-0.8-0.80.61.10.00.90.8
Extensor digitorum longus weight5.321.233.1-5.75.7-5.7-5.7-5.75.84.00.01.00.5
Bone: elastic displacement0.00.00.10.2-0.20.00.20.2-0.0-0.30.0-0.2-0.2
Bone: elastic work0.00.00.0-0.0-0.1-0.00.10.10.10.10.0-0.00.0
Bone: endosteal estimation0.92.34.9-2.21.9-1.8-1.8-1.81.81.10.00.30.1
Bone: endosteal perimeter1.02.44.9-2.21.9-1.8-1.9-1.91.81.10.00.40.2
Epididymis fat weight0.00.10.3-0.60.3-0.2-0.2-0.20.30.2-0.6-0.1-0.1
Delta time in closed arm before/after self-admin3.02.83.8-1.91.9-1.7-1.8-1.81.91.8-0.71.41.3
Delta time in open arm before/after self-admin0.10.10.30.10.0-0.1-0.1-0.1-0.0-0.3-0.5-0.6-0.6
Diff in mean of infusions in LGA sessions0.00.10.6-0.80.2-0.2-0.2-0.20.1-0.00.10.20.2
Delay discount exponential model param1.31.85.3-0.60.7-0.7-0.7-0.71.01.41.42.32.3
Extinction: sum of active levers before priming0.40.62.1-0.80.6-0.5-0.5-0.50.60.9-1.5-0.5-0.6
Active lever presses in extinction session 60.10.10.20.10.00.20.20.2-0.10.50.10.30.3
Bone: final force0.81.32.21.3-1.51.51.41.4-1.4-0.80.0-0.10.0
Bone: final moment0.71.11.81.2-1.31.41.31.3-1.3-0.90.0-0.1-0.0
Food consumed during 24 hour testing period0.30.71.6-1.00.9-0.8-0.8-0.81.31.00.00.10.0
Glucose0.61.02.11.0-0.90.80.90.9-0.8-0.8-0.7-1.4-1.4
Heart weight3.04.85.7-2.32.3-2.3-2.4-2.42.32.4-0.12.32.2
Delay discount hyperbolic model param1.41.85.5-0.50.7-0.7-0.6-0.61.01.41.52.32.3
Intermittent access intake day 1-15 change0.10.41.0-0.70.3-0.3-0.3-0.30.10.70.80.91.0
Intermittent access intake escalation0.10.41.1-0.70.3-0.2-0.2-0.20.10.71.01.01.1
Intermittent access intake escalation 20.91.64.1-0.90.8-0.7-0.8-0.80.81.61.12.02.0
Intermitt. access day 1 inactive lever presses0.10.71.50.4-0.60.70.60.6-0.9-1.1-0.1-1.2-1.2
Intermitt. access day 15 inactive lever presses0.10.72.51.1-0.70.70.70.7-0.8-0.41.60.60.7
Intermitt. access escalation Index0.30.91.8-1.00.9-1.0-0.9-0.91.40.8-0.80.80.7
Intermittent access day 1 total infusions0.00.10.4-0.10.0-0.00.10.1-0.2-0.1-0.3-0.6-0.6
Intermittent access day 15 total infusions0.00.10.5-0.70.2-0.2-0.1-0.10.00.50.20.10.2
Intermittent access terminal intake (last 3 days)0.10.20.7-0.3-0.20.20.20.2-0.30.40.80.40.5
Intermittent access total infusions0.10.10.3-0.50.2-0.3-0.2-0.20.10.4-0.3-0.2-0.2
Intermittent access day 1 locomotion0.20.41.10.3-0.30.40.40.4-0.5-0.8-0.4-1.0-1.0
Intermittent access day 15 total locomotion0.20.71.30.7-0.91.01.01.0-1.1-0.40.7-0.6-0.5
Intermittent access total locomotion1.01.11.81.1-1.11.21.11.1-1.4-1.10.8-0.9-0.8
Intermittent access standard deviation0.00.21.00.0-0.20.30.20.2-0.40.21.00.60.6
Left kidney weight0.54.49.1-2.32.2-2.3-2.2-2.22.51.6-3.0-0.0-0.3
Right kidney weight0.10.72.5-0.70.6-0.7-0.6-0.61.00.4-1.6-0.5-0.6
Cocaine induced anxiety1.64.35.7-2.32.1-2.1-2.1-2.12.12.4-0.22.12.0
Post-drug Anxiety1.01.12.2-1.20.9-0.9-0.9-0.90.81.10.51.51.5
Baseline Anxiety2.03.34.72.2-2.02.02.02.0-1.9-2.10.7-1.5-1.4
Tail length2.915.469.4-2.52.6-2.6-2.5-2.52.50.2-8.3-4.5-5.1
Length with tail4.319.158.0-4.64.5-4.4-4.3-4.34.62.4-7.6-1.7-2.3
Length without tail1.57.712.0-3.23.1-3.1-3.1-3.13.52.6-2.21.61.4
Times rat made contact with spout0.70.81.51.2-1.11.21.11.1-0.7-0.70.0-0.3-0.2
Lifetime Intake0.00.00.1-0.40.1-0.1-0.0-0.0-0.00.2-0.2-0.3-0.3
Liver weight, left0.20.30.4-0.50.4-0.6-0.6-0.60.50.7-0.60.10.1
Liver weight, right0.61.02.90.7-0.60.60.60.6-0.6-0.7-1.1-1.7-1.7
Locomotor activity0.40.61.11.0-0.91.01.01.0-0.9-0.60.0-0.1-0.1
Locomotor testing distance1.33.35.92.1-2.12.42.22.2-2.3-1.60.0-0.3-0.1
Locomotor testing rearing1.34.88.32.8-2.72.92.72.7-2.7-1.60.0-0.4-0.2
Locomotion in novel chamber2.93.97.52.7-1.81.81.81.8-1.6-1.8-0.9-2.5-2.5
Locomotion in novel chamber post-restriction0.20.62.50.4-0.70.60.60.6-0.2-0.21.60.80.9
Fecal boli incidents, locomotor time 10.51.43.9-0.40.8-0.7-0.7-0.70.51.31.51.92.0
Change in fecal boli incidents, locomotor task1.11.12.80.6-0.80.80.80.8-0.8-1.1-1.0-1.7-1.7
Time >=10cm from walls, locomotor time 10.50.61.20.9-0.80.70.70.7-0.8-0.80.2-1.1-1.0
Bouts of movement, locomotor time 10.30.50.9-0.80.9-0.9-0.9-0.90.50.1-0.5-0.1-0.1
Total resting periods, locomotor time 10.50.61.0-0.90.9-1.0-1.0-1.00.60.0-0.6-0.1-0.1
Rest time, locomotor task time 10.10.20.4-0.20.3-0.3-0.3-0.30.3-0.7-0.3-0.5-0.5
Distance moved, locomotor task time 10.10.30.60.2-0.60.60.60.6-0.5-0.4-0.6-0.8-0.8
Vertical activity count, locomotor time 10.00.00.3-0.40.1-0.2-0.1-0.10.00.5-0.10.10.1
Time >=10cm from walls, locomotor time 20.72.04.51.5-1.11.11.01.0-1.3-1.7-0.4-2.1-2.1
Bouts of movement, locomotor time 20.00.10.40.4-0.10.10.00.0-0.6-0.40.5-0.1-0.1
Total resting periods, locomotor time 20.00.10.30.10.2-0.2-0.2-0.2-0.4-0.30.50.10.1
Rest time, locomotor task time 20.71.22.3-1.11.4-1.4-1.5-1.51.00.5-0.20.80.8
Distance moved, locomotor task time 20.30.51.90.0-0.10.10.10.10.1-0.2-1.4-1.1-1.2
Vertical activity count, locomotor time 20.20.51.6-0.30.1-0.00.00.00.1-0.2-1.3-1.2-1.2
Light reinforcement 10.42.03.31.4-1.81.71.81.8-1.6-1.60.0-0.4-0.2
Light reinforcement 20.20.51.10.7-1.01.01.01.0-0.8-0.60.0-0.2-0.1
Bone: marrow area0.92.24.7-2.21.9-1.8-1.8-1.81.81.10.00.30.1
Bone: maximum diameter0.00.00.1-0.0-0.10.20.10.1-0.10.00.00.20.2
Bone: maximum force0.00.00.10.1-0.30.30.30.3-0.20.10.00.10.1
Bone: maximum moment0.00.00.0-0.0-0.20.20.20.2-0.20.00.00.10.1
Mean time between licks in bursts0.31.93.7-1.61.7-1.7-1.9-1.91.60.70.00.20.1
Mean num. licks in bursts0.00.00.0-0.00.00.0-0.1-0.1-0.00.20.00.00.1
Cd content in liver0.60.71.7-1.31.1-0.9-1.1-1.10.60.60.00.20.2
Co content in liver1.51.72.9-1.71.6-1.6-1.6-1.61.51.30.00.50.3
Cu content in liver0.60.71.3-0.91.1-1.1-1.1-1.11.10.40.00.40.3
Fe content in liver1.41.82.8-1.61.6-1.6-1.6-1.61.71.20.00.40.3
K content in liver0.00.00.10.30.3-0.1-0.3-0.30.10.00.0-0.1-0.1
Mg content in liver0.00.00.20.50.00.0-0.0-0.0-0.0-0.00.0-0.0-0.0
Mn content in liver0.00.00.10.30.10.2-0.1-0.1-0.2-0.10.00.00.0
Na content in liver0.10.10.60.5-0.20.30.20.2-0.1-0.80.0-0.1-0.0
Rb content in liver0.91.01.61.3-1.11.21.11.1-1.3-1.20.0-0.4-0.2
Se content in liver1.72.04.32.1-1.71.81.71.7-1.7-1.20.0-0.3-0.1
Sr content in liver0.80.71.0-1.01.0-1.0-1.0-1.01.00.80.00.20.1
Zn content in liver0.91.01.91.4-1.11.21.11.1-1.3-1.20.0-0.2-0.0
Bone: minimum diameter0.30.51.1-1.10.8-0.6-0.7-0.70.81.00.00.40.3
Time in familiar zone, hab. session 10.40.40.80.6-0.80.90.80.8-0.7-0.20.0-0.3-0.3
Time in novel zone, hab. session 10.40.50.90.9-0.80.60.80.8-0.8-0.90.0-0.00.0
Total zone transitions, hab. session 11.62.23.4-1.81.9-1.8-1.8-1.81.81.40.00.20.0
Total locomotion distance, hab. session 10.00.00.1-0.30.1-0.0-0.1-0.10.1-0.20.0-0.1-0.1
Locomotion velocity, hab. session 10.30.51.1-1.00.9-0.7-0.8-0.80.80.30.00.10.0
Time in familiar zone, hab. session 20.40.50.90.6-0.90.80.90.9-0.9-0.80.0-0.3-0.2
Time in novel zone, hab. session 20.00.00.00.2-0.00.10.00.0-0.1-0.00.00.00.1
Total zone transitions, hab. session 20.40.61.0-1.00.9-0.8-1.0-1.00.80.60.00.1-0.0
Total locomotion distance, hab. session 20.00.10.3-0.50.3-0.1-0.3-0.30.20.10.0-0.0-0.1
Locomotion velocity, hab. session 20.10.20.6-0.80.5-0.3-0.5-0.50.40.30.00.0-0.0
Novel to familiar place preference ratio0.81.01.9-1.11.2-1.3-1.1-1.11.41.10.00.20.1
Novelty place preference0.40.61.1-0.90.8-1.0-0.8-0.81.00.80.00.20.1
Time in novel zone, NPP test0.10.10.3-0.30.4-0.5-0.4-0.40.60.50.00.0-0.0
Total zone transitions, NPP test0.20.30.6-0.80.7-0.5-0.6-0.60.60.50.0-0.0-0.1
Total locomotion distance, NPP test0.00.00.1-0.1-0.10.10.10.1-0.0-0.30.0-0.1-0.1
Locomotion velocity, NPP test0.10.20.5-0.70.6-0.5-0.5-0.50.60.20.00.0-0.0
Intraocular pressure0.91.42.4-1.51.3-1.2-1.3-1.31.11.4-1.60.30.1
Delta distance traveled before/after self-admin0.70.81.7-0.90.7-0.5-0.7-0.70.71.30.41.21.2
Delta ambulatory time before/after self-admin0.20.30.7-0.70.2-0.1-0.3-0.30.40.80.20.80.8
Parametrial fat weight0.61.42.30.8-1.01.21.31.3-1.3-1.5-0.1-1.4-1.4
Pavlov. Cond. lever latency1.72.24.0-1.81.8-2.0-1.8-1.81.91.30.00.30.1
Pavlov. Cond. magazine entry latency6.58.313.43.6-3.63.73.63.6-3.5-2.40.0-0.4-0.1
Pavlov. Cond. change in total contacts5.86.210.33.2-3.23.13.23.2-2.9-1.60.0-0.4-0.1
Pavlov. Cond. index score6.27.812.93.4-3.53.63.53.5-3.4-2.30.0-0.5-0.2
Pavlov. Cond. latency score4.86.110.23.0-3.13.23.13.1-3.0-2.00.0-0.4-0.1
Pavlov. Cond. lever contacts2.22.74.62.0-2.02.12.02.0-2.0-1.50.0-0.3-0.1
Pavlov. Cond. magazine entry number9.211.718.7-4.34.3-4.3-4.3-4.34.12.60.00.60.2
Pavlov. Cond. intertrial magazine entries1.11.42.4-1.31.5-1.4-1.5-1.51.41.00.00.20.0
Pavlov. Cond. lever-magazine prob. diff.7.29.014.73.7-3.73.83.83.8-3.6-2.40.0-0.5-0.2
Pavlov. Cond. response bias7.08.814.23.6-3.73.83.73.7-3.6-2.40.0-0.5-0.2
Pavlov. Cond. lever latency0.30.40.7-0.60.9-0.8-0.8-0.80.40.60.00.20.1
Pavlov. Cond. magazine entry latency0.00.00.1-0.00.0-0.1-0.1-0.10.3-0.00.00.0-0.0
Pavlov. Cond. change in total contacts0.20.50.80.7-0.90.80.90.9-0.7-0.70.0-0.3-0.2
Pavlov. Cond. index score0.10.20.50.5-0.70.60.60.6-0.2-0.40.0-0.2-0.1
Pavlov. Cond. latency score0.10.20.40.4-0.60.60.60.6-0.2-0.40.0-0.1-0.1
Pavlov. Cond. lever contacts0.40.61.10.8-1.01.01.01.0-0.7-0.80.0-0.2-0.2
Pavlov. Cond. magazine entry number0.10.20.4-0.50.6-0.5-0.5-0.50.30.50.00.10.1
Pavlov. Cond. intertrial magazine entries0.71.42.3-1.51.5-1.5-1.5-1.51.41.00.00.30.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.3-0.50.40.40.4-0.1-0.40.0-0.1-0.1
Pavlov. Cond. response bias0.60.81.41.1-1.21.11.11.1-0.8-0.90.0-0.2-0.2
Time in closed arm before self-admin1.01.82.61.3-1.61.61.51.5-1.4-1.41.4-0.3-0.2
Time in closed arm after self-admin0.30.40.8-0.60.5-0.3-0.4-0.40.70.60.20.90.9
Time in open arm before self-admin2.22.63.5-1.61.9-1.9-1.8-1.81.71.7-0.41.61.5
Time in open arm after self-admin0.50.50.9-0.60.9-0.9-0.9-0.90.70.5-0.70.20.1
Bone: periosteal estimation0.10.20.4-0.70.5-0.4-0.4-0.40.40.40.00.20.2
Bone: periosteal perimeter0.30.71.4-1.21.0-0.8-1.0-1.00.90.70.00.40.3
Bone: post-yield work0.30.61.3-1.11.0-0.9-1.0-1.00.80.30.00.10.0
Progressive ratio test 1 active lever presses0.61.12.70.5-0.80.80.90.9-0.9-1.0-0.8-1.6-1.6
Progressive ratio test 1 breakpoint0.61.02.40.4-0.80.80.90.9-0.9-1.0-0.7-1.5-1.5
Progressive ratio test 1 inactive lever presses0.10.20.7-0.1-0.20.30.30.3-0.4-0.6-0.2-0.8-0.8
Progressive ratio test 2 active lever presses0.40.51.10.7-0.70.70.80.8-0.8-0.5-0.1-1.0-1.0
Progressive ratio test 2 breakpoint0.50.71.40.7-0.70.70.80.8-0.8-0.5-0.2-1.2-1.1
Progressive ratio test 2 inactive lever presses0.10.20.4-0.30.6-0.6-0.5-0.50.30.6-0.5-0.1-0.1
Incentive Sensitization - Responses0.20.50.90.9-0.70.70.70.7-0.7-0.50.3-0.7-0.7
Incentive Sensitization - Breakpoint0.10.30.70.9-0.50.50.60.6-0.6-0.30.3-0.6-0.6
Sum of active levers in priming session hrs 5-60.80.72.40.3-0.30.40.40.4-0.40.0-1.3-1.5-1.6
Progressive ratio0.00.00.1-0.10.10.0-0.0-0.00.1-0.3-0.30.10.0
Food seeking constrained by brief footshock0.30.40.60.6-0.80.70.70.7-0.8-0.50.7-0.2-0.2
Seeking ratio, punishment vs. effort0.10.20.30.6-0.50.40.40.4-0.50.10.3-0.4-0.4
Retroperitoneal fat weight0.20.92.00.4-0.70.90.90.9-1.0-1.4-0.1-1.2-1.2
Reaction time number correct0.20.71.2-1.01.1-1.0-1.1-1.11.10.40.00.20.1
Reaction time mean minus median0.00.00.0-0.1-0.1-0.1-0.1-0.10.10.10.00.20.2
Reaction time mean minus median AUC0.10.40.90.7-1.00.70.60.6-0.7-0.70.00.00.1
Reaction time num false alarms0.30.61.00.9-0.81.01.01.0-1.0-0.40.0-0.4-0.3
Reaction time num false alarms AUC0.20.40.80.8-0.70.80.90.9-0.8-0.40.0-0.4-0.4
Reaction time trials correct on left0.20.71.2-1.01.1-1.0-1.1-1.11.10.40.00.20.1
Reaction time trials on left0.20.61.1-1.01.0-0.9-1.0-1.01.00.40.00.20.1
Reaction time mean0.00.00.10.3-0.1-0.0-0.0-0.0-0.0-0.20.00.20.2
Reaction time mean AUC0.00.00.10.3-0.1-0.2-0.1-0.10.0-0.10.00.20.2
Median of all reaction times0.10.10.60.8-0.40.30.30.3-0.3-0.40.00.10.1
Reaction time omissions0.20.41.00.6-1.00.70.80.8-0.7-0.40.0-0.00.0
Reaction time false alarm rate0.81.11.91.2-1.21.31.41.4-1.3-0.70.0-0.5-0.4
Reaction time premature initiation rate0.20.30.70.4-0.60.80.70.7-0.5-0.60.0-0.00.0
Reaction time premature initiations0.00.00.2-0.40.2-0.0-0.2-0.20.3-0.20.00.10.1
Std. dev. reaction times0.00.10.20.3-0.40.20.20.2-0.2-0.20.00.20.2
Reaction time trials completed0.20.61.1-1.01.0-0.9-1.0-1.01.00.40.00.20.1
Reaction time trials AUC0.20.51.0-0.90.9-0.9-1.0-1.01.00.30.00.10.0
Run reversals in cocaine runway, females0.91.01.6-1.31.0-1.1-1.1-1.11.01.0-1.10.10.0
Run reversals in cocaine runway, males0.91.04.80.7-0.40.50.50.5-0.50.22.21.21.4
Latency to leave start box in cocaine runway2.83.85.7-1.82.0-2.0-2.0-2.01.82.00.72.42.4
Latency to leave start box in cocaine runway, F3.34.16.4-1.92.0-2.0-2.0-2.02.11.80.62.52.5
Latency to leave start box in cocaine runway, M0.60.61.3-0.40.8-0.8-0.8-0.80.61.10.30.80.8
Std. dev. time between licks in bursts0.10.20.5-0.50.5-0.7-0.6-0.60.70.40.00.20.1
Total sessions with >9 infusions0.10.10.3-0.1-0.20.20.30.3-0.3-0.2-0.3-0.6-0.6
Short access day 1 total inactive lever presses0.91.94.60.8-1.01.01.11.1-1.2-1.6-0.9-2.1-2.1
Short access day 10 total inactive lever presses0.21.63.9-1.11.0-0.8-0.9-0.90.80.91.51.92.0
Short access day 1 total infusions0.00.00.00.1-0.00.00.10.1-0.20.0-0.1-0.1-0.1
Short access day 10 total infusions0.10.10.30.4-0.40.40.50.5-0.60.20.4-0.2-0.2
Short access total infusions0.00.00.0-0.00.1-0.1-0.0-0.0-0.00.1-0.2-0.1-0.1
Short access day 1 locomotion0.30.50.70.8-0.80.90.90.9-0.9-0.60.5-0.5-0.4
Short access day 10 total locomotion0.72.84.41.8-1.82.11.91.9-2.0-1.51.7-0.5-0.4
Short access total locomotion0.20.30.50.4-0.50.60.60.6-0.6-0.60.7-0.1-0.0
One hour access (0.3 mA shock)0.10.10.3-0.4-0.00.10.20.2-0.3-0.2-0.2-0.5-0.5
Compulsive drug intake0.91.33.80.2-0.60.40.50.5-0.4-1.4-1.6-1.8-1.9
One hour access (shock baseline)0.20.41.0-0.60.4-0.2-0.2-0.20.10.91.00.91.0
Social response proportion0.00.00.10.00.0-0.2-0.0-0.0-0.2-0.30.0-0.1-0.1
Social responses0.00.00.10.2-0.30.10.30.3-0.4-0.20.0-0.1-0.1
Social time0.00.00.1-0.10.1-0.10.00.00.10.30.00.10.1
Soleus weight0.31.01.81.3-1.21.21.31.3-1.1-0.90.0-0.10.0
Bone: stiffness0.00.10.10.1-0.30.30.30.3-0.3-0.10.00.30.3
Tibialis anterior weight0.82.95.2-1.92.1-2.1-2.1-2.12.31.50.00.50.3
Time to tail flick, vehicle, before self-admin0.50.61.50.4-0.50.60.70.7-0.8-0.7-0.8-1.2-1.2
Time to tail flick, vehicle, after self-admin0.20.40.90.4-0.30.60.50.5-0.20.30.90.91.0
Time to tail flick, test, before self-admin0.40.51.0-0.70.5-0.5-0.3-0.30.61.00.51.01.0
Time to tail flick, test, after self-admin0.10.10.20.4-0.30.20.30.3-0.2-0.00.40.10.2
Delta time to tail flick, vehicle, before/after SA0.70.72.60.7-0.70.70.60.6-0.4-0.11.60.91.0
Delta time to tail flick, test, before/after SA1.72.13.81.5-1.31.31.11.1-1.3-1.8-0.6-2.0-1.9
Tibia length0.41.12.3-1.31.2-1.2-1.2-1.21.51.00.00.40.3
Ambulatory time before self-admin0.20.61.6-0.91.3-1.0-1.0-1.00.60.4-0.40.20.1
Ambulatory time after self-admin1.32.13.7-1.91.6-1.4-1.5-1.51.31.8-0.51.21.1
Bone: tissue strength0.20.20.6-0.60.5-0.7-0.5-0.50.80.60.00.20.1
Total heroin consumption0.20.20.80.9-0.40.50.40.4-0.6-0.20.0-0.5-0.5
Bone: trabecular number2.95.48.62.9-2.92.92.92.9-2.9-2.00.0-0.3-0.1
Bone: trabecular spacing0.60.81.5-1.21.1-1.1-1.1-1.11.00.80.00.10.0
Bone: trabecular thickness0.00.00.00.2-0.10.0-0.0-0.00.0-0.00.00.10.1
Bone: trabecular tissue density0.00.00.0-0.10.0-0.2-0.1-0.10.10.10.00.0-0.0
Water consumed over 24 hours0.00.00.0-0.0-0.10.20.20.20.2-0.10.0-0.2-0.2
Number of responses in last shaping day0.30.31.1-0.10.4-0.3-0.2-0.20.51.10.40.90.9