Hub : Genes

Larp4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Larp4	0.03	0.04	2.3e-03	0.01	0.01	0.01	0.01	5.1e-02	7.5e-03	1.6e-02	4.1e-02
2	PL	gene expression	Larp4	0.03	0.02	5.0e-04	0.03	0.03	0.02	0.02	6.1e-04	3.9e-04	5.7e-03	2.4e-03
3	Adipose	alternative TSS	XM_039080369.2	0.02	0.02	2.1e-03	0.02	0.02	0.01	0.01	5.7e-03	5.1e-03	2.9e-02	2.5e-02
4	Adipose	alternative TSS	XM_039080369.2	0.03	0.03	5.7e-04	0.02	0.02	0.01	0.01	1.7e-03	1.6e-03	9.1e-03	6.9e-03
5	Brain	mRNA stability	Larp4	0.04	0.03	3.1e-04	0.04	0.04	0.03	0.04	6.2e-05	3.3e-04	7.6e-04	1.9e-04
6	pVTA	gene expression	Larp4	0.05	0.04	6.3e-04	0.03	0.03	0.03	0.03	1.7e-03	1.3e-03	1.6e-03	2.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	6.3	10.8	12.1	3.5	3.4	-3.3	-3.2	3.3	3.0
Area under the delay curve	1.0	1.1	1.2	1.0	1.1	-1.1	-1.1	1.1	1.1
BMI with tail	6.2	21.5	22.2	4.7	4.7	-4.7	-4.7	4.5	4.5
BMI without tail	1.7	5.1	5.7	2.4	2.4	-2.2	-2.2	2.1	2.2
Body weight	6.8	29.7	32.1	5.7	5.6	-5.5	-5.4	5.3	5.2
Weight adjusted by age	0.4	0.7	0.9	0.6	0.7	-0.9	-1.0	0.9	0.7
Bone surface	8.3	15.2	17.1	4.1	4.0	-3.9	-3.9	3.7	3.7
Bone volume	7.9	14.1	15.5	3.9	3.9	-3.7	-3.7	3.7	3.6
Breakpoint value in progressive ratio session	0.6	0.7	0.8	0.9	0.9	-0.8	-0.8	0.8	0.7
Number of licking bursts	0.8	1.2	1.5	-1.2	-1.2	1.0	1.0	-1.2	-1.0
Context. condit. distance diff. score	0.3	0.3	0.5	0.7	0.6	-0.6	-0.6	0.5	0.5
Locomotion velocity, session 1	4.2	4.5	4.9	-2.2	-2.2	2.1	2.1	-2.1	-2.2
Locomotion distance, session 1	3.1	3.9	4.3	-2.1	-2.0	2.0	1.9	-1.9	-1.9
Locomotion velocity, session 2	0.4	0.4	0.5	-0.6	-0.7	0.7	0.7	-0.6	-0.7
Locomotion distance, session 2	3.3	4.6	5.1	-2.2	-2.2	2.1	2.1	-2.0	-2.1
Locomotion velocity, session 3	4.9	5.6	5.9	-2.3	-2.4	2.4	2.4	-2.3	-2.4
Locomotion distance, session 3	2.9	3.2	3.9	-1.5	-1.7	2.0	2.0	-1.7	-1.8
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.2	-0.1	-0.2	-0.3	0.2	0.1
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.4	-0.3	0.1	0.1	-0.0	-0.2
Locomotion velocity, session 7	2.8	3.1	3.8	-1.6	-1.7	1.8	1.9	-1.6	-1.9
Locomotion distance, session 7	3.7	4.7	5.2	-2.0	-2.1	2.3	2.3	-2.0	-2.3
Stereotopy head waving bouts, day 7	0.7	0.8	1.1	0.7	0.8	-1.1	-1.1	0.8	1.0
Stereotopy head waving duration, day 7	1.0	1.2	1.5	0.9	1.0	-1.2	-1.2	1.0	1.2
Locomotion velocity, session 8	0.4	0.5	0.6	-0.7	-0.7	0.7	0.7	-0.6	-0.8
Locomotion distance, session 8	1.1	1.6	1.7	-1.2	-1.2	1.3	1.3	-1.3	-1.3
Degree of sensitization distance	0.0	0.0	0.0	-0.1	0.0	-0.2	-0.2	0.1	0.0
Degree of sensitization stereotypy	0.6	0.7	0.9	0.7	0.8	-0.9	-0.9	0.6	0.9
Conditioned locomotion	0.1	0.1	0.2	-0.3	-0.3	0.3	0.3	-0.4	-0.3
Cocaine response after cond. corrected	0.0	0.0	0.1	-0.2	-0.2	0.0	0.0	-0.0	-0.1
Cocaine response after cond. not corrected	0.3	0.3	0.4	-0.6	-0.6	0.6	0.6	-0.4	-0.5
Cocaine response before conditioning	1.8	2.2	2.6	-1.3	-1.4	1.6	1.6	-1.5	-1.5
Saline control response	0.0	0.0	0.1	0.1	-0.1	0.2	0.2	-0.1	-0.2
Bone: connectivity density	3.0	4.6	5.5	2.3	2.3	-2.1	-2.1	2.1	1.9
Bone: cortical apparent density	0.2	0.3	0.8	-0.9	-0.7	0.5	0.4	-0.2	-0.4
Bone: cortical area	6.3	9.6	10.8	3.3	3.2	-3.1	-3.1	3.0	2.9
Bone: cortical porosity	0.1	0.1	0.2	0.4	0.3	-0.1	-0.1	-0.0	0.3
Bone: cortical porosity	0.0	0.0	0.0	0.2	0.1	0.1	0.1	-0.2	0.0
Bone: cortical thickness	2.0	3.3	3.6	1.9	1.9	-1.8	-1.8	1.7	1.7
Bone: cortical thickness	0.2	0.2	0.3	-0.3	-0.3	0.5	0.5	-0.4	-0.6
Bone: cortical tissue density	0.3	0.4	0.9	-1.0	-0.8	0.6	0.6	-0.3	-0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.2	-0.2	0.2	0.2	-0.4	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	0.5	0.5	-0.4	-0.4	0.2	0.3
Condit. Reinf. active responses	0.7	0.8	0.9	-0.9	-0.9	0.9	0.9	-0.9	-0.9
Condit. Reinf. inactive responses	2.6	3.2	4.0	-2.0	-1.9	1.8	1.8	-1.6	-1.7
Incentive salience index mean	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.0	0.1
Condit. Reinf. lever presses	0.4	0.6	0.7	0.6	0.7	-0.8	-0.8	0.7	0.8
Condit. Reinf. active minus inactive responses	0.8	1.0	1.3	1.0	1.0	-1.0	-1.0	0.9	1.2
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.0	0.8	0.9	-0.8	-0.8	0.7	1.0
Condit. Reinf. active responses	0.1	0.1	0.2	0.3	0.3	-0.3	-0.3	0.3	0.4
Condit. Reinf. inactive responses	0.6	0.8	0.9	-0.9	-0.9	0.9	0.9	-0.8	-0.9
Condit. Reinf. lever presses	0.0	0.0	0.1	0.2	0.1	-0.0	-0.0	0.3	0.0
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	-0.0	-0.0	0.1	0.1	-0.1	0.0
Conditioned reinforcement - actives	0.5	0.8	0.9	-0.9	-0.9	1.0	1.0	-0.8	-0.8
Conditioned reinforcement - inactives	4.0	5.9	6.7	-2.3	-2.4	2.5	2.5	-2.6	-2.4
Conditioned locomotion	0.3	0.4	0.8	-0.5	-0.5	0.6	0.6	-0.9	-0.5
Patch foraging indifference point 0 sec	5.3	9.7	11.0	-2.9	-3.0	3.1	3.2	-3.3	-3.2
Patch foraging indifference point AUC	0.7	1.0	1.3	-1.1	-1.1	0.9	0.9	-0.9	-0.9
Delay disc. indifference point, 0s delay	2.0	2.1	2.2	1.5	1.5	-1.5	-1.5	1.3	1.5
Delay disc. indifference point, 16s delay	0.7	0.8	1.0	0.9	0.9	-0.9	-0.9	1.0	0.8
Delay disc. indifference point, 2s delay	1.8	2.0	2.4	1.2	1.3	-1.5	-1.6	1.4	1.5
Delay disc. indifference point, 24s delay	0.4	0.5	0.5	0.6	0.7	-0.7	-0.7	0.6	0.6
Delay disc. indifference point, 4s delay	1.3	1.3	1.4	1.2	1.2	-1.2	-1.2	1.1	1.2
Delay disc. indifference point, 8s delay	1.1	1.3	1.4	1.2	1.2	-1.1	-1.1	1.2	1.0
Indifference point function ln k	3.7	6.6	7.0	2.7	2.6	-2.5	-2.5	2.6	2.5
Indifference point function log k	3.7	6.6	7.0	2.7	2.6	-2.5	-2.5	2.6	2.5
Patch foraging total patch changes 0 sec	4.8	9.1	10.2	-2.8	-2.9	3.1	3.1	-3.2	-3.1
Patch foraging total patch changes 12 sec	6.4	8.3	8.8	-2.8	-2.9	2.9	2.9	-3.0	-2.9
Patch foraging total patch changes 18 sec	5.8	8.9	9.3	-3.0	-3.0	3.0	3.0	-2.8	-3.0
Patch foraging total patch changes 24 sec	3.3	5.6	6.1	-2.3	-2.3	2.4	2.4	-2.5	-2.4
Patch foraging total patch changes 6 sec	6.8	10.4	11.3	-3.2	-3.2	3.2	3.2	-3.4	-3.3
Patch foraging time to switch 0 sec	1.8	3.8	4.1	-2.0	-2.0	2.0	2.0	-1.7	-1.9
Patch foraging water rate 0 sec	2.9	6.2	6.8	2.6	2.6	-2.5	-2.5	2.2	2.5
Patch foraging water rate 12 sec	1.9	4.0	4.4	2.1	2.1	-2.0	-2.0	1.9	1.9
Patch foraging water rate 18 sec	0.3	0.5	0.6	0.7	0.7	-0.8	-0.8	0.6	0.8
Patch foraging water rate 24 sec	4.7	6.5	7.1	2.5	2.5	-2.6	-2.6	2.7	2.5
Patch foraging water rate 6 sec	6.3	9.2	9.7	3.1	3.1	-3.0	-3.0	3.0	3.0
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.5	0.7	0.7	-0.7	-0.7	0.5	0.7
Distance traveled before self-admin	2.1	2.8	2.9	-1.7	-1.7	1.6	1.6	-1.7	-1.7
Distance traveled after self-admin	1.3	1.5	1.7	-1.1	-1.2	1.3	1.3	-1.3	-1.3
Extensor digitorum longus weight	4.9	19.3	21.0	4.0	4.3	-4.6	-4.6	4.5	4.4
Bone: elastic displacement	6.7	7.8	7.9	-2.8	-2.8	2.8	2.8	-2.7	-2.8
Bone: elastic work	0.0	0.1	0.1	-0.2	-0.2	0.3	0.3	-0.2	-0.3
Bone: endosteal estimation	6.8	14.9	16.9	4.1	4.0	-3.8	-3.8	3.7	3.7
Bone: endosteal perimeter	6.5	13.8	15.3	3.9	3.8	-3.7	-3.7	3.6	3.6
Epididymis fat weight	0.3	0.9	1.7	1.3	1.1	-0.8	-0.8	0.9	0.7
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.2	0.1	-0.1	-0.1	0.2	0.1
Delta time in open arm before/after self-admin	1.2	1.2	1.5	-1.0	-1.0	1.2	1.2	-0.9	-1.2
Diff in mean of infusions in LGA sessions	0.7	0.8	0.9	0.9	0.9	-1.0	-1.0	0.8	0.8
Delay discount exponential model param	1.0	1.1	1.2	-1.0	-1.0	1.1	1.1	-1.1	-1.0
Extinction: sum of active levers before priming	2.3	2.6	2.9	1.6	1.6	-1.7	-1.7	1.4	1.6
Active lever presses in extinction session 6	0.1	0.1	0.2	0.4	0.3	-0.3	-0.3	0.2	0.1
Bone: final force	11.3	18.0	19.9	4.5	4.4	-4.2	-4.2	4.2	4.1
Bone: final moment	12.6	20.3	22.5	4.7	4.6	-4.5	-4.4	4.4	4.3
Food consumed during 24 hour testing period	1.5	2.1	2.6	1.6	1.5	-1.4	-1.4	1.4	1.4
Glucose	0.4	0.6	0.9	-0.7	-0.7	0.7	0.7	-0.9	-0.9
Heart weight	0.2	0.3	0.7	0.8	0.7	-0.5	-0.5	0.4	0.5
Delay discount hyperbolic model param	1.0	1.1	1.2	-1.0	-1.0	1.1	1.1	-1.0	-1.0
Intermittent access intake day 1-15 change	0.1	0.2	0.5	0.5	0.4	-0.2	-0.2	0.7	0.4
Intermittent access intake escalation	0.3	0.7	1.2	0.9	0.8	-0.6	-0.6	1.1	0.8
Intermittent access intake escalation 2	0.1	0.2	0.5	0.4	0.3	-0.2	-0.2	0.7	0.3
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.4	-0.4	0.3	0.3	-0.5	-0.2
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	0.0	0.0	0.1	0.1	-0.1	0.2
Intermitt. access escalation Index	0.0	0.0	0.1	-0.1	0.0	-0.3	-0.3	-0.1	0.2
Intermittent access day 1 total infusions	1.2	1.9	2.4	-1.3	-1.3	1.4	1.4	-1.6	-1.3
Intermittent access day 15 total infusions	0.4	0.6	0.7	-0.7	-0.7	0.8	0.8	-0.7	-0.7
Intermittent access terminal intake (last 3 days)	0.6	0.8	0.9	-0.8	-0.9	1.0	1.0	-0.8	-0.8
Intermittent access total infusions	1.2	1.4	1.6	-1.1	-1.1	1.2	1.2	-1.2	-1.1
Intermittent access day 1 locomotion	1.0	1.3	1.7	-1.0	-1.1	1.1	1.1	-1.3	-1.2
Intermittent access day 15 total locomotion	0.3	0.6	0.9	-0.4	-0.6	0.9	0.9	-1.0	-0.8
Intermittent access total locomotion	2.3	2.8	3.1	-1.5	-1.6	1.7	1.7	-1.8	-1.7
Intermittent access standard deviation	0.0	0.1	0.2	-0.1	-0.2	0.4	0.4	0.1	-0.3
Left kidney weight	1.5	7.2	8.2	2.9	2.8	-2.6	-2.6	2.6	2.6
Right kidney weight	4.3	19.8	21.4	4.6	4.6	-4.5	-4.4	4.3	4.3
Cocaine induced anxiety	2.1	3.0	3.6	1.8	1.8	-1.6	-1.6	1.9	1.5
Post-drug Anxiety	3.7	4.0	4.6	2.1	2.1	-1.9	-1.9	2.1	1.8
Baseline Anxiety	0.3	0.3	0.5	0.6	0.6	-0.6	-0.6	0.5	0.7
Tail length	0.0	0.0	0.1	0.3	0.2	-0.0	-0.0	-0.2	0.0
Length with tail	1.6	7.0	8.0	2.8	2.8	-2.6	-2.6	2.5	2.5
Length without tail	5.7	18.3	19.2	4.4	4.4	-4.3	-4.3	4.2	4.1
Times rat made contact with spout	0.0	0.0	0.0	0.1	0.1	0.1	0.1	-0.0	-0.0
Lifetime Intake	2.0	2.5	2.7	-1.5	-1.5	1.6	1.6	-1.7	-1.5
Liver weight, left	10.2	16.9	19.2	4.4	4.3	-4.1	-4.1	3.9	4.0
Liver weight, right	3.3	5.8	6.7	2.6	2.5	-2.3	-2.3	2.4	2.3
Locomotor activity	1.2	1.8	1.9	-1.3	-1.3	1.4	1.4	-1.3	-1.4
Locomotor testing distance	2.9	5.2	5.5	-2.2	-2.3	2.3	2.3	-2.3	-2.3
Locomotor testing rearing	1.6	3.2	3.8	-1.6	-1.7	1.9	1.9	-1.6	-1.8
Locomotion in novel chamber	4.8	6.1	6.9	2.5	2.5	-2.4	-2.4	2.6	2.5
Locomotion in novel chamber post-restriction	0.2	0.3	0.5	0.6	0.5	-0.4	-0.4	0.7	0.5
Fecal boli incidents, locomotor time 1	0.8	1.2	1.8	-0.9	-1.0	1.1	1.1	-1.3	-1.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.1	0.2	-0.3	-0.3	0.5	0.2
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.7	-0.7	-0.7	0.7	0.7	-0.8	-0.8
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.2	-0.1	-0.0	-0.0	-0.2	-0.0
Total resting periods, locomotor time 1	0.5	0.5	0.7	-0.8	-0.8	0.7	0.7	-0.7	-0.7
Rest time, locomotor task time 1	0.7	0.9	1.0	-1.0	-1.0	0.9	0.9	-0.9	-0.9
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.0	-0.1	-0.0
Vertical activity count, locomotor time 1	0.4	1.0	1.1	1.0	1.0	-1.0	-1.0	0.8	1.0
Time >=10cm from walls, locomotor time 2	0.4	0.5	0.6	-0.7	-0.7	0.8	0.8	-0.7	-0.7
Bouts of movement, locomotor time 2	2.6	4.1	4.3	2.0	2.0	-2.1	-2.1	2.0	2.0
Total resting periods, locomotor time 2	2.6	4.6	4.8	2.1	2.1	-2.2	-2.2	2.1	2.1
Rest time, locomotor task time 2	0.2	0.3	0.6	-0.5	-0.5	0.4	0.4	-0.8	-0.4
Distance moved, locomotor task time 2	0.0	0.1	0.1	-0.3	-0.3	0.2	0.2	-0.0	-0.2
Vertical activity count, locomotor time 2	0.1	0.2	0.3	0.4	0.4	-0.4	-0.4	0.6	0.4
Light reinforcement 1	0.7	1.7	2.0	-1.4	-1.3	1.3	1.3	-1.4	-1.1
Light reinforcement 2	0.0	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.2
Bone: marrow area	6.4	13.9	15.9	4.0	3.9	-3.7	-3.7	3.6	3.5
Bone: maximum diameter	1.6	3.0	3.6	1.9	1.8	-1.8	-1.7	1.6	1.6
Bone: maximum force	14.1	25.0	26.3	5.1	5.1	-5.0	-5.0	4.9	4.8
Bone: maximum moment	15.7	27.6	29.2	5.4	5.4	-5.3	-5.3	5.2	5.1
Mean time between licks in bursts	0.1	0.2	0.3	-0.6	-0.5	0.4	0.4	-0.2	-0.4
Mean num. licks in bursts	0.4	0.6	0.9	1.0	0.8	-0.6	-0.5	0.8	0.6
Cd content in liver	0.2	0.2	0.3	-0.5	-0.5	0.5	0.5	-0.5	-0.4
Co content in liver	0.2	0.3	0.3	-0.5	-0.5	0.5	0.5	-0.5	-0.5
Cu content in liver	0.1	0.1	0.3	0.6	0.5	-0.3	-0.3	0.3	0.2
Fe content in liver	1.6	2.0	2.1	-1.4	-1.4	1.5	1.5	-1.3	-1.4
K content in liver	0.2	0.2	0.3	-0.4	-0.4	0.4	0.4	-0.3	-0.5
Mg content in liver	0.2	0.2	0.2	-0.4	-0.4	0.4	0.4	-0.2	-0.4
Mn content in liver	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1	-0.2	-0.2
Na content in liver	0.0	0.0	0.0	0.2	0.1	0.0	0.0	0.1	-0.0
Rb content in liver	1.4	1.7	2.0	-1.1	-1.2	1.3	1.3	-1.4	-1.4
Se content in liver	3.7	4.4	4.5	-2.0	-2.1	2.1	2.1	-2.1	-2.1
Sr content in liver	0.6	0.5	0.7	0.8	0.7	-0.7	-0.6	0.7	0.6
Zn content in liver	0.8	0.9	1.0	-0.9	-0.9	1.0	1.0	-0.9	-1.0
Bone: minimum diameter	7.9	14.5	15.4	3.9	3.9	-3.8	-3.8	3.7	3.7
Time in familiar zone, hab. session 1	0.0	0.0	0.0	0.0	0.0	-0.1	-0.1	0.2	0.2
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.1	0.1
Total zone transitions, hab. session 1	0.1	0.1	0.3	-0.6	-0.4	0.2	0.2	-0.3	-0.1
Total locomotion distance, hab. session 1	0.3	0.5	0.7	-0.8	-0.8	0.6	0.6	-0.7	-0.7
Locomotion velocity, hab. session 1	0.2	0.3	0.4	-0.6	-0.6	0.4	0.4	-0.5	-0.5
Time in familiar zone, hab. session 2	1.6	1.7	1.9	1.3	1.3	-1.3	-1.3	1.4	1.3
Time in novel zone, hab. session 2	1.8	1.9	2.2	-1.4	-1.4	1.3	1.3	-1.5	-1.4
Total zone transitions, hab. session 2	0.2	0.3	0.4	-0.6	-0.6	0.5	0.5	-0.4	-0.5
Total locomotion distance, hab. session 2	0.4	0.6	0.7	-0.8	-0.8	0.7	0.7	-0.7	-0.8
Locomotion velocity, hab. session 2	0.2	0.3	0.3	-0.6	-0.6	0.6	0.6	-0.5	-0.6
Novel to familiar place preference ratio	1.4	1.5	1.8	1.1	1.2	-1.3	-1.3	1.1	1.2
Novelty place preference	0.8	0.9	1.1	0.8	0.9	-1.0	-1.0	0.8	0.9
Time in novel zone, NPP test	0.5	0.6	0.8	0.6	0.7	-0.9	-0.9	0.6	0.8
Total zone transitions, NPP test	2.7	4.0	4.4	-2.1	-2.0	1.9	1.9	-2.0	-2.0
Total locomotion distance, NPP test	3.7	5.0	5.5	-2.3	-2.3	2.2	2.2	-2.2	-2.2
Locomotion velocity, NPP test	2.4	3.4	3.6	-1.9	-1.9	1.8	1.8	-1.8	-1.9
Intraocular pressure	5.5	7.9	8.5	-2.8	-2.8	2.9	2.9	-2.7	-2.7
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.4	0.3	-0.0	0.0	0.2	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.2	0.1	0.2	0.2	0.1	-0.1
Parametrial fat weight	0.4	1.0	1.2	-1.0	-1.0	1.1	1.1	-0.8	-1.0
Pavlov. Cond. lever latency	0.2	0.3	0.4	-0.5	-0.5	0.5	0.5	-0.5	-0.6
Pavlov. Cond. magazine entry latency	1.1	1.4	1.8	1.1	1.2	-1.2	-1.2	1.1	1.3
Pavlov. Cond. change in total contacts	1.5	1.6	2.0	1.2	1.2	-1.3	-1.3	1.2	1.4
Pavlov. Cond. index score	1.0	1.3	1.5	1.1	1.1	-1.1	-1.1	1.1	1.2
Pavlov. Cond. latency score	0.8	1.0	1.3	1.0	1.0	-1.0	-1.0	1.0	1.1
Pavlov. Cond. lever contacts	0.2	0.2	0.3	0.4	0.5	-0.4	-0.4	0.5	0.6
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	-0.8	-0.9	0.9	0.9	-0.7	-1.0
Pavlov. Cond. intertrial magazine entries	5.0	6.0	6.7	-2.5	-2.5	2.4	2.4	-2.3	-2.6
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.7	2.0	1.2	1.3	-1.3	-1.3	1.2	1.4
Pavlov. Cond. response bias	0.3	0.4	0.6	0.6	0.6	-0.6	-0.6	0.5	0.8
Pavlov. Cond. lever latency	0.8	1.1	1.4	1.0	1.0	-1.1	-1.1	0.9	1.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	-0.4	-0.4	0.4	0.4	-0.4	-0.6
Pavlov. Cond. change in total contacts	0.5	0.8	1.0	0.8	0.9	-1.0	-1.0	0.9	0.8
Pavlov. Cond. index score	0.2	0.3	0.5	-0.5	-0.5	0.5	0.5	-0.4	-0.7
Pavlov. Cond. latency score	0.3	0.4	0.6	-0.6	-0.6	0.6	0.6	-0.5	-0.8
Pavlov. Cond. lever contacts	0.6	0.8	1.1	-0.8	-0.9	0.9	0.9	-0.8	-1.0
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0	0.0	0.2
Pavlov. Cond. intertrial magazine entries	1.8	2.8	3.5	-1.4	-1.5	1.9	1.9	-1.7	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	-0.4	-0.4	0.4	0.4	-0.3	-0.6
Pavlov. Cond. response bias	0.2	0.3	0.5	-0.5	-0.5	0.6	0.6	-0.5	-0.7
Time in closed arm before self-admin	1.4	1.7	2.7	1.1	1.2	-1.3	-1.4	1.7	1.2
Time in closed arm after self-admin	0.4	0.4	1.1	0.4	0.5	-0.6	-0.6	1.0	0.6
Time in open arm before self-admin	0.4	0.4	0.6	-0.8	-0.7	0.5	0.5	-0.8	-0.5
Time in open arm after self-admin	0.3	0.3	0.4	-0.6	-0.6	0.5	0.5	-0.7	-0.6
Bone: periosteal estimation	9.5	20.1	22.6	4.8	4.7	-4.5	-4.5	4.3	4.2
Bone: periosteal perimeter	9.0	15.4	16.9	4.1	4.1	-4.0	-3.9	3.7	3.8
Bone: post-yield work	6.8	10.0	10.5	3.2	3.2	-3.1	-3.1	3.2	3.0
Progressive ratio test 1 active lever presses	7.2	8.9	9.3	-2.9	-3.0	3.0	3.0	-3.0	-2.9
Progressive ratio test 1 breakpoint	7.0	8.6	9.0	-2.8	-2.9	3.0	3.0	-2.9	-2.9
Progressive ratio test 1 inactive lever presses	0.4	0.6	0.7	-0.8	-0.8	0.8	0.8	-0.7	-0.6
Progressive ratio test 2 active lever presses	1.5	1.7	1.9	-1.2	-1.3	1.4	1.4	-1.3	-1.2
Progressive ratio test 2 breakpoint	1.3	1.5	1.6	-1.2	-1.2	1.3	1.3	-1.3	-1.2
Progressive ratio test 2 inactive lever presses	0.4	0.6	0.8	-0.7	-0.7	0.9	0.9	-0.8	-0.7
Incentive Sensitization - Responses	0.6	0.8	0.9	0.9	0.9	-0.9	-0.9	0.9	0.9
Incentive Sensitization - Breakpoint	0.5	0.7	0.7	0.8	0.8	-0.8	-0.8	0.8	0.9
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.3	-0.3	0.2	0.2	-0.5	-0.3
Progressive ratio	1.4	2.1	2.4	-1.5	-1.5	1.4	1.4	-1.3	-1.5
Food seeking constrained by brief footshock	3.1	3.8	4.1	-2.0	-2.0	2.0	2.0	-1.7	-2.0
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	0.3	0.3	-0.2	-0.2	0.2	0.3
Retroperitoneal fat weight	0.8	3.3	3.8	-1.6	-1.7	1.9	1.9	-1.7	-2.0
Reaction time number correct	0.8	1.5	2.1	1.4	1.3	-1.1	-1.1	1.3	1.0
Reaction time mean minus median	3.0	7.4	8.0	-2.7	-2.7	2.8	2.8	-2.8	-2.6
Reaction time mean minus median AUC	2.1	5.2	5.4	-2.3	-2.3	2.3	2.3	-2.3	-2.2
Reaction time num false alarms	1.4	2.0	2.6	-1.5	-1.4	1.3	1.3	-1.6	-1.2
Reaction time num false alarms AUC	1.5	2.4	3.0	-1.7	-1.6	1.4	1.4	-1.7	-1.3
Reaction time trials correct on left	0.8	1.5	2.1	1.4	1.3	-1.1	-1.1	1.3	1.0
Reaction time trials on left	0.6	1.1	1.7	1.3	1.1	-0.9	-0.9	1.1	0.9
Reaction time mean	0.6	1.0	1.3	-0.9	-0.9	1.0	1.0	-1.1	-1.0
Reaction time mean AUC	0.4	0.6	0.9	-0.6	-0.7	0.8	0.8	-0.9	-0.7
Median of all reaction times	0.0	0.0	0.1	0.0	-0.0	0.1	0.1	-0.3	-0.1
Reaction time omissions	7.9	11.6	12.1	-3.4	-3.4	3.5	3.5	-3.3	-3.3
Reaction time false alarm rate	1.8	2.5	3.3	-1.8	-1.7	1.4	1.4	-1.8	-1.3
Reaction time premature initiation rate	3.2	4.4	5.1	-2.1	-2.1	2.3	2.3	-1.7	-2.1
Reaction time premature initiations	1.0	1.7	2.4	-1.2	-1.3	1.5	1.5	-0.9	-1.4
Std. dev. reaction times	3.8	7.0	7.9	-2.6	-2.6	2.7	2.7	-2.8	-2.5
Reaction time trials completed	0.6	1.1	1.7	1.3	1.1	-0.9	-0.9	1.1	0.9
Reaction time trials AUC	1.0	2.0	2.7	1.6	1.5	-1.3	-1.3	1.5	1.2
Run reversals in cocaine runway, females	0.6	0.6	1.3	0.7	0.7	-0.6	-0.6	1.2	0.7
Run reversals in cocaine runway, males	0.5	0.5	0.7	-0.8	-0.8	0.7	0.7	-0.7	-0.6
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.1	-0.0	0.1
Latency to leave start box in cocaine runway, F	0.9	1.1	1.5	-1.2	-1.1	1.0	1.0	-1.0	-0.9
Latency to leave start box in cocaine runway, M	1.9	1.8	1.9	1.3	1.3	-1.4	-1.4	1.3	1.3
Std. dev. time between licks in bursts	1.1	1.5	1.6	-1.3	-1.3	1.2	1.2	-1.3	-1.2
Total sessions with >9 infusions	2.3	2.8	3.2	-1.7	-1.7	1.7	1.7	-1.8	-1.6
Short access day 1 total inactive lever presses	1.5	1.9	2.1	-1.4	-1.4	1.5	1.5	-1.2	-1.3
Short access day 10 total inactive lever presses	0.0	0.1	0.1	0.3	0.3	-0.3	-0.3	0.1	0.4
Short access day 1 total infusions	1.1	1.5	1.7	-1.1	-1.2	1.3	1.3	-1.2	-1.3
Short access day 10 total infusions	1.9	2.4	2.5	-1.5	-1.5	1.6	1.6	-1.5	-1.5
Short access total infusions	3.4	4.4	4.7	-1.9	-2.0	2.2	2.2	-2.1	-2.1
Short access day 1 locomotion	0.4	0.5	0.5	-0.7	-0.7	0.7	0.7	-0.7	-0.7
Short access day 10 total locomotion	0.3	0.5	0.6	-0.6	-0.7	0.8	0.8	-0.7	-0.7
Short access total locomotion	1.1	1.3	1.4	-1.1	-1.1	1.2	1.2	-1.2	-1.1
One hour access (0.3 mA shock)	0.3	0.3	0.5	0.7	0.6	-0.5	-0.5	0.5	0.7
Compulsive drug intake	0.3	0.4	0.5	0.6	0.6	-0.7	-0.7	0.5	0.7
One hour access (shock baseline)	0.2	0.3	0.4	0.6	0.6	-0.4	-0.4	0.5	0.5
Social response proportion	0.1	0.1	0.2	-0.2	-0.3	0.4	0.4	-0.4	-0.4
Social responses	4.5	5.8	6.6	-2.4	-2.4	2.4	2.4	-2.6	-2.2
Social time	0.4	0.5	0.7	0.8	0.8	-0.6	-0.6	0.7	0.6
Soleus weight	0.9	2.7	2.9	1.7	1.7	-1.6	-1.6	1.7	1.6
Bone: stiffness	19.4	31.5	32.0	5.7	5.7	-5.6	-5.6	5.6	5.5
Tibialis anterior weight	3.2	10.8	12.3	2.8	3.1	-3.5	-3.5	3.3	3.5
Time to tail flick, vehicle, before self-admin	1.1	1.2	1.3	-1.1	-1.1	1.1	1.1	-1.0	-1.1
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.7	0.5	0.6	-0.6	-0.6	0.8	0.6
Time to tail flick, test, before self-admin	0.2	0.2	0.3	-0.6	-0.5	0.5	0.5	-0.3	-0.5
Time to tail flick, test, after self-admin	1.2	1.2	1.7	1.0	1.0	-1.0	-1.0	1.3	1.0
Delta time to tail flick, vehicle, before/after SA	0.7	0.6	0.8	0.9	0.8	-0.7	-0.7	0.9	0.7
Delta time to tail flick, test, before/after SA	0.6	0.6	0.7	0.8	0.8	-0.8	-0.8	0.7	0.8
Tibia length	4.5	12.5	15.2	3.9	3.8	-3.5	-3.5	3.3	3.2
Ambulatory time before self-admin	2.4	3.6	3.9	-1.9	-1.9	1.9	1.9	-2.0	-1.9
Ambulatory time after self-admin	1.9	2.2	2.5	-1.3	-1.4	1.6	1.6	-1.5	-1.5
Bone: tissue strength	1.5	1.5	1.6	1.2	1.2	-1.3	-1.3	1.1	1.2
Total heroin consumption	0.5	0.5	0.8	0.9	0.8	-0.7	-0.7	0.5	0.7
Bone: trabecular number	3.3	5.5	6.7	2.6	2.5	-2.3	-2.3	2.3	2.1
Bone: trabecular spacing	0.9	1.2	1.5	-1.2	-1.1	1.0	1.0	-1.1	-0.9
Bone: trabecular thickness	0.4	0.4	0.6	0.6	0.6	-0.6	-0.6	0.8	0.7
Bone: trabecular tissue density	0.8	1.2	1.9	0.7	0.9	-1.2	-1.2	1.1	1.4
Water consumed over 24 hours	0.0	0.0	0.1	0.3	0.2	0.0	0.0	0.2	-0.0
Number of responses in last shaping day	0.0	0.0	0.1	-0.0	0.0	-0.1	-0.1	0.3	0.2