Hub : Genes

Lap3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg mRNA stability Lap3 0.15 0.1 3.5e-03 0.05 0.1 0.05 0.07 1.8e-02 1.7e-03 1.8e-02 7.5e-03
2 pVTA gene expression Lap3 0.03 0.02 7.4e-03 0.04 0.02 0.02 0.03 2.8e-04 4.8e-03 5.4e-03 1.2e-03
3 PL mRNA stability Lap3 0.08 0.04 2.9e-13 0.12 0.13 0.12 0.12 4.7e-13 2.9e-14 3.9e-13 2.4e-13
4 OFC gene expression Lap3 0.11 0.07 4.9e-03 0.1 0.09 0.03 0.09 2.2e-03 4.2e-03 8.2e-02 4.2e-03
5 Brain gene expression Lap3 0.15 0.07 7.2e-16 0.16 0.15 0.15 0.14 1.3e-14 6.8e-14 4.6e-14 3.1e-13
6 pVTA mRNA stability Lap3 0.05 0.04 3.2e-04 0.04 0.04 0.04 0.04 4.9e-04 2.8e-04 8.2e-04 8.0e-04
7 Adipose mRNA stability Lap3 0.03 0.02 1.2e-03 0.03 0.02 0.02 0.02 7.4e-04 1.9e-03 2.9e-03 3.0e-03
8 Liver gene expression Lap3 0.14 0.06 0.0e+00 0.16 0.15 0.15 0.16 1.4e-17 1.0e-16 3.1e-16 3.8e-17
9 NAcc mRNA stability Lap3 0.03 0.02 1.4e-07 0.04 0.04 0.03 0.04 1.9e-07 2.0e-06 6.6e-06 3.0e-06
10 Brain mRNA stability Lap3 0.07 0.04 2.1e-06 0.08 0.07 0.07 0.05 1.5e-07 3.3e-07 3.6e-07 3.3e-05
11 Liver mRNA stability Lap3 0.12 0.06 6.9e-12 0.09 0.08 0.07 0.07 9.9e-10 3.5e-09 5.7e-08 2.6e-08
12 LHb gene expression Lap3 0.24 0.13 2.0e-03 0.08 0.12 0.11 0.12 7.2e-03 8.6e-04 1.6e-03 9.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.20.31.70.5-0.30.2-0.3-0.60.4-0.3-0.10.20.5-0.1-1.3
Area under the delay curve3.64.25.52.2-2.32.2-2.3-2.02.0-2.3-2.22.21.42.3-0.4
BMI with tail0.20.73.4-0.10.5-0.10.70.3-0.80.40.6-0.6-1.8-0.9-1.2
BMI without tail0.72.26.1-1.11.5-1.01.51.4-1.81.31.4-1.4-2.5-1.70.3
Body weight4.017.622.3-4.74.3-4.44.34.2-4.64.24.6-4.6-3.4-4.60.3
Weight adjusted by age0.91.43.5-1.91.0-1.61.11.1-0.91.21.2-1.40.8-1.20.0
Bone surface0.61.11.8-1.11.2-1.31.20.9-0.91.21.1-1.0-0.1-1.30.1
Bone volume0.10.20.90.3-0.20.2-0.2-0.50.6-0.2-0.40.61.00.20.2
Breakpoint value in progressive ratio session0.40.51.21.1-0.90.5-0.8-0.50.7-0.8-0.40.41.10.6-0.5
Number of licking bursts2.33.75.12.3-2.21.8-2.1-2.21.8-2.1-1.61.61.51.7-2.1
Context. condit. distance diff. score0.20.20.9-0.90.3-0.40.30.00.10.3-0.10.11.0-0.00.5
Locomotion velocity, session 10.30.40.70.20.8-0.40.60.6-0.50.60.6-0.6-0.8-0.50.9
Locomotion distance, session 10.40.53.70.90.50.10.40.5-0.20.40.1-0.1-0.8-0.11.9
Locomotion velocity, session 20.30.31.21.1-0.00.5-0.1-0.1-0.0-0.1-0.10.2-1.00.21.1
Locomotion distance, session 20.50.72.70.80.5-0.20.60.7-0.80.50.7-0.7-1.6-0.41.2
Locomotion velocity, session 30.20.21.00.20.0-0.3-0.00.00.00.00.5-0.50.7-0.3-1.0
Locomotion distance, session 35.35.78.2-2.52.6-2.92.52.6-2.42.62.7-2.7-0.6-2.50.6
Stereotopy head waving bouts, day 32.73.24.41.6-2.12.0-2.1-2.01.7-2.0-1.91.80.52.1-0.6
Stereotopy head waving duration, day 33.94.77.02.2-2.42.6-2.4-2.52.0-2.4-2.32.20.12.4-0.9
Locomotion velocity, session 70.40.41.0-0.50.8-0.50.60.7-0.70.60.5-0.5-0.9-0.41.0
Locomotion distance, session 70.50.61.1-0.51.0-0.90.91.0-0.70.90.7-0.7-0.1-0.71.0
Stereotopy head waving bouts, day 71.21.32.10.5-1.20.9-1.5-1.21.2-1.5-1.11.01.31.3-0.9
Stereotopy head waving duration, day 71.01.21.60.6-1.11.0-1.3-1.21.1-1.3-1.01.01.11.1-1.0
Locomotion velocity, session 80.30.30.60.4-0.80.5-0.7-0.70.6-0.6-0.50.50.40.7-0.4
Locomotion distance, session 80.10.21.80.30.20.10.20.1-0.00.2-0.10.2-0.40.21.3
Degree of sensitization distance4.54.66.82.2-2.22.5-2.0-2.22.2-2.2-2.62.61.02.40.3
Degree of sensitization stereotypy0.20.20.6-0.2-0.30.1-0.5-0.30.3-0.5-0.20.20.80.4-0.6
Conditioned locomotion1.71.92.51.4-1.51.5-1.6-1.31.4-1.6-1.51.41.01.6-0.7
Cocaine response after cond. corrected0.30.41.0-0.40.4-0.60.50.6-0.80.50.8-0.9-1.0-0.50.3
Cocaine response after cond. not corrected1.01.11.9-0.80.9-1.00.91.0-1.31.01.3-1.3-1.4-1.00.5
Cocaine response before conditioning0.70.91.2-1.01.0-1.11.01.0-1.01.01.0-0.9-0.5-1.00.5
Saline control response0.20.31.4-0.50.3-0.70.20.7-0.10.20.2-0.21.2-0.00.8
Bone: connectivity density0.71.11.9-0.90.9-1.10.90.6-1.00.91.3-1.2-0.6-1.4-1.3
Bone: cortical apparent density0.40.61.7-0.5-0.80.3-0.8-0.80.6-0.8-0.50.51.10.5-1.3
Bone: cortical area0.20.31.7-0.4-0.5-0.0-0.3-0.20.5-0.3-0.40.51.30.3-0.5
Bone: cortical porosity0.10.10.6-0.50.10.10.30.0-0.10.3-0.30.3-0.30.20.8
Bone: cortical porosity0.10.10.7-0.50.2-0.10.40.20.00.4-0.20.20.20.10.9
Bone: cortical thickness1.83.04.51.4-1.81.5-1.7-1.82.0-1.7-1.71.82.11.6-1.3
Bone: cortical thickness0.60.73.80.2-0.70.2-0.5-0.61.0-0.6-0.70.82.00.8-0.0
Bone: cortical tissue density0.40.61.9-0.5-0.70.3-0.8-0.80.6-0.8-0.50.51.00.5-1.4
Condit. Reinf. active minus inactive responses2.42.74.0-1.41.5-1.51.71.9-1.81.71.5-1.4-1.9-1.22.0
Condit. Reinf. active-inactive response ratio2.72.94.1-2.01.6-1.81.72.0-1.91.71.5-1.5-1.5-1.21.9
Condit. Reinf. active responses2.22.74.9-1.31.6-1.41.71.8-1.91.71.6-1.5-2.2-1.51.3
Condit. Reinf. inactive responses0.30.41.30.20.5-0.30.60.3-0.60.60.7-0.6-1.2-0.9-0.6
Incentive salience index mean3.03.74.7-1.62.0-1.92.02.2-2.12.12.0-1.9-1.9-1.91.5
Condit. Reinf. lever presses4.05.66.9-2.32.6-2.52.62.6-2.52.62.6-2.4-1.8-2.50.7
Condit. Reinf. active minus inactive responses0.91.11.6-1.21.1-1.21.21.3-1.01.21.0-1.0-0.3-1.00.9
Condit. Reinf. active-inactive response ratio0.81.01.4-0.60.9-1.01.01.1-1.21.01.2-1.1-1.1-1.00.6
Condit. Reinf. active responses2.12.94.1-1.72.0-1.91.92.0-1.51.91.4-1.5-0.5-1.62.0
Condit. Reinf. inactive responses2.22.84.5-1.42.1-1.72.01.8-1.32.11.3-1.4-0.7-1.72.0
Condit. Reinf. lever presses0.50.72.2-1.00.8-1.00.81.0-0.50.80.5-0.40.3-0.51.5
Condit. Reinf. lever reinforcers received1.72.45.0-1.41.8-1.71.81.8-1.21.81.2-1.2-0.2-1.42.2
Conditioned reinforcement - actives0.10.31.80.60.50.40.1-0.0-0.20.0-0.10.0-1.3-0.00.7
Conditioned reinforcement - inactives0.40.62.21.5-0.41.1-0.5-1.20.8-0.4-0.60.4-0.10.40.0
Conditioned locomotion1.01.35.7-0.80.6-0.60.71.0-1.50.91.1-1.2-2.4-1.00.5
Patch foraging indifference point 0 sec0.10.20.40.60.5-0.10.40.2-0.30.50.5-0.5-0.6-0.70.0
Patch foraging indifference point AUC0.30.41.4-0.1-0.70.3-0.6-0.60.7-0.7-0.50.51.20.7-0.7
Delay disc. indifference point, 0s delay0.20.32.41.5-0.30.5-0.2-0.30.1-0.20.1-0.1-0.6-0.10.0
Delay disc. indifference point, 16s delay1.31.52.51.1-1.31.3-1.3-1.01.1-1.3-1.41.40.51.60.3
Delay disc. indifference point, 2s delay2.93.25.12.2-2.02.1-2.0-1.71.7-1.9-1.91.90.72.0-0.1
Delay disc. indifference point, 24s delay6.16.89.22.7-2.52.8-2.9-3.02.6-2.9-2.62.61.42.6-2.2
Delay disc. indifference point, 4s delay1.51.54.42.1-1.31.4-1.3-1.11.2-1.3-1.11.10.41.20.0
Delay disc. indifference point, 8s delay2.52.94.51.1-1.91.5-1.7-1.51.8-1.9-1.91.92.12.1-0.1
Indifference point function ln k0.30.53.50.70.50.40.30.1-0.40.4-0.00.0-1.9-0.21.2
Indifference point function log k0.30.53.50.70.50.40.30.1-0.40.4-0.00.0-1.9-0.21.2
Patch foraging total patch changes 0 sec0.10.10.30.60.40.00.30.1-0.20.30.3-0.3-0.5-0.40.2
Patch foraging total patch changes 12 sec0.00.10.50.0-0.3-0.0-0.1-0.1-0.0-0.10.0-0.10.1-0.1-0.7
Patch foraging total patch changes 18 sec2.13.24.6-1.21.9-2.01.91.9-1.62.12.1-2.1-0.5-2.10.9
Patch foraging total patch changes 24 sec0.00.00.2-0.10.2-0.20.2-0.10.1-0.0-0.00.00.40.10.2
Patch foraging total patch changes 6 sec0.00.10.50.1-0.1-0.0-0.0-0.0-0.10.10.2-0.30.0-0.3-0.7
Patch foraging time to switch 0 sec1.32.74.5-1.11.4-1.81.51.7-1.81.72.1-2.1-1.3-2.1-0.6
Patch foraging water rate 0 sec0.30.51.10.4-0.50.8-0.6-0.80.8-0.7-1.01.00.60.90.2
Patch foraging water rate 12 sec0.10.32.6-0.40.5-0.10.40.20.00.3-0.10.10.30.11.6
Patch foraging water rate 18 sec0.20.30.8-0.90.8-0.50.70.4-0.40.40.3-0.3-0.4-0.20.7
Patch foraging water rate 24 sec0.10.10.7-0.70.1-0.20.20.3-0.20.2-0.0-0.00.30.10.9
Patch foraging water rate 6 sec0.10.20.5-0.40.30.00.1-0.10.3-0.1-0.50.50.60.50.7
Seeking ratio, delayed vs. immediate footshock0.10.10.6-0.70.20.10.20.2-0.20.2-0.20.3-0.50.20.8
Distance traveled before self-admin0.10.11.20.0-0.5-0.1-0.30.1-0.2-0.10.3-0.2-0.2-0.2-1.1
Distance traveled after self-admin0.10.10.2-0.20.1-0.2-0.10.4-0.20.20.2-0.40.0-0.4-0.5
Extensor digitorum longus weight1.14.45.8-2.32.2-2.42.02.3-2.31.92.4-2.4-1.6-2.20.1
Bone: elastic displacement1.01.22.01.4-0.91.1-1.0-1.11.4-1.1-1.21.31.01.10.2
Bone: elastic work0.91.22.40.6-1.10.8-1.0-0.91.3-1.1-1.21.31.51.3-0.2
Bone: endosteal estimation2.14.66.7-2.62.1-2.42.32.5-2.32.32.1-2.0-1.3-2.11.2
Bone: endosteal perimeter1.53.25.1-2.21.6-2.31.82.1-1.91.91.9-1.9-0.4-1.80.6
Epididymis fat weight1.65.510.5-3.22.3-2.52.32.3-2.62.22.5-2.3-1.9-2.6-0.4
Delta time in closed arm before/after self-admin1.41.32.7-0.81.0-0.91.11.0-1.31.11.2-1.2-1.6-1.10.8
Delta time in open arm before/after self-admin0.80.81.5-0.81.2-1.11.11.0-0.51.00.7-0.80.4-0.90.8
Diff in mean of infusions in LGA sessions0.40.51.90.1-0.1-0.3-0.10.4-0.8-0.10.7-0.6-1.4-0.4-1.3
Delay discount exponential model param4.55.06.5-2.32.5-2.42.52.2-2.22.52.4-2.4-1.5-2.60.6
Extinction: sum of active levers before priming0.00.10.10.3-0.30.1-0.10.2-0.2-0.30.00.0-0.30.20.4
Active lever presses in extinction session 62.22.13.11.6-1.81.5-1.7-1.41.4-1.7-1.41.41.21.5-1.0
Bone: final force0.20.30.8-0.8-0.50.1-0.4-0.30.4-0.4-0.70.80.90.6-0.1
Bone: final moment0.10.20.8-0.9-0.3-0.1-0.2-0.10.2-0.1-0.40.50.90.3-0.1
Food consumed during 24 hour testing period2.83.97.4-2.72.1-2.32.12.0-2.12.11.9-1.9-1.0-2.00.6
Glucose1.82.85.3-2.01.6-1.61.61.7-2.01.61.5-1.6-2.3-1.40.9
Heart weight1.72.65.9-2.41.9-1.71.91.5-1.61.81.4-1.4-0.6-1.60.7
Delay discount hyperbolic model param4.75.26.7-2.42.6-2.52.52.2-2.32.52.4-2.4-1.4-2.60.5
Intermittent access intake day 1-15 change1.32.63.7-1.61.9-1.51.81.6-1.81.81.3-1.4-1.7-1.61.1
Intermittent access intake escalation0.81.72.6-1.31.5-1.11.41.3-1.51.51.0-1.1-1.6-1.21.0
Intermittent access intake escalation 22.02.23.1-1.51.7-1.41.61.5-1.71.71.2-1.3-1.7-1.40.9
Intermitt. access day 1 inactive lever presses0.20.61.3-0.60.7-1.00.70.8-0.60.71.1-1.10.3-0.8-0.1
Intermitt. access day 15 inactive lever presses0.81.72.7-1.31.6-1.31.61.2-1.21.61.2-1.2-1.0-1.50.6
Intermitt. access escalation Index0.10.10.40.4-0.70.3-0.5-0.10.0-0.5-0.40.4-0.30.3-0.1
Intermittent access day 1 total infusions0.10.10.30.5-0.40.4-0.6-0.40.3-0.5-0.3-0.00.00.5-0.1
Intermittent access day 15 total infusions0.71.13.3-0.81.2-0.60.90.9-1.31.10.7-1.0-1.8-0.80.9
Intermittent access terminal intake (last 3 days)0.40.51.8-0.50.9-0.30.60.5-0.80.70.3-0.7-1.4-0.50.8
Intermittent access total infusions0.20.21.5-0.10.30.20.10.2-0.40.2-0.1-0.2-1.20.10.9
Intermittent access day 1 locomotion0.20.30.80.7-0.50.6-0.5-0.1-0.0-0.4-0.30.2-0.80.60.9
Intermittent access day 15 total locomotion0.20.30.6-0.70.4-0.40.40.5-0.70.40.6-0.8-0.8-0.40.1
Intermittent access total locomotion0.40.52.4-0.20.3-0.20.30.6-0.90.40.5-0.6-1.5-0.21.0
Intermittent access standard deviation0.10.20.6-0.3-0.30.6-0.4-0.70.4-0.4-0.80.60.10.5-0.2
Left kidney weight0.31.63.3-1.80.9-1.41.01.5-1.51.11.3-1.2-0.9-1.01.0
Right kidney weight0.20.81.5-1.20.4-0.90.40.9-1.20.51.1-1.0-1.1-0.7-0.9
Cocaine induced anxiety0.70.91.91.4-0.81.3-1.0-1.00.6-1.1-0.90.9-1.00.6-0.8
Post-drug Anxiety0.40.51.30.8-0.60.8-0.7-0.70.4-0.8-0.50.5-0.50.3-1.2
Baseline Anxiety0.50.61.6-1.30.4-1.10.60.9-0.60.60.9-0.90.8-0.5-0.3
Tail length2.811.115.1-3.93.4-3.83.43.7-3.53.53.5-3.5-1.5-3.41.9
Length with tail4.017.327.1-5.24.3-4.94.34.5-4.24.44.4-4.4-1.6-4.12.1
Length without tail2.06.612.7-3.62.5-3.12.62.6-2.52.62.8-2.8-0.7-2.60.3
Times rat made contact with spout0.30.42.7-0.60.3-0.50.20.0-0.30.20.5-0.50.1-0.6-1.6
Lifetime Intake0.20.31.6-0.20.30.00.10.3-0.60.2-0.0-0.3-1.30.00.9
Liver weight, left2.84.710.0-3.22.0-2.32.12.3-2.52.22.1-2.0-1.8-2.00.9
Liver weight, right1.83.27.8-2.81.3-2.11.52.0-2.21.61.9-1.9-1.2-1.7-0.0
Locomotor activity1.01.66.1-2.51.1-1.50.91.3-1.30.91.2-1.1-0.7-0.9-0.5
Locomotor testing distance0.61.13.5-1.91.1-1.40.91.2-0.90.90.8-0.8-0.0-0.60.9
Locomotor testing rearing0.10.20.8-0.90.3-0.50.30.4-0.20.30.2-0.20.4-0.10.6
Locomotion in novel chamber0.10.10.60.0-0.50.4-0.4-0.3-0.2-0.2-0.10.1-0.80.1-0.5
Locomotion in novel chamber post-restriction0.61.02.60.6-1.11.0-1.1-1.10.7-1.2-0.80.80.00.9-1.6
Fecal boli incidents, locomotor time 10.30.42.30.4-0.30.6-0.4-0.20.3-0.4-0.70.7-0.40.91.5
Change in fecal boli incidents, locomotor task0.30.30.6-0.60.5-0.70.50.5-0.30.60.6-0.60.3-0.8-0.5
Time >=10cm from walls, locomotor time 11.01.11.9-0.91.1-1.11.10.8-1.11.01.4-1.4-0.8-1.2-0.5
Bouts of movement, locomotor time 10.40.41.9-0.6-0.3-0.1-0.5-0.0-0.7-0.20.5-0.5-1.1-0.2-1.4
Total resting periods, locomotor time 10.50.51.9-0.70.1-0.2-0.20.1-0.80.10.8-0.7-1.4-0.5-1.3
Rest time, locomotor task time 10.50.62.2-1.51.0-0.80.60.7-0.80.70.6-0.6-0.6-0.6-0.0
Distance moved, locomotor task time 10.10.11.00.4-0.2-0.00.10.0-0.00.1-0.10.00.00.01.0
Vertical activity count, locomotor time 10.51.22.41.6-1.21.3-0.9-1.11.1-1.0-1.21.20.51.10.4
Time >=10cm from walls, locomotor time 21.52.33.5-1.31.7-1.61.51.5-1.61.41.9-1.9-1.0-1.7-0.2
Bouts of movement, locomotor time 20.30.42.2-1.50.5-0.80.60.7-0.60.60.5-0.50.2-0.40.1
Total resting periods, locomotor time 20.40.72.7-1.70.8-1.00.81.0-0.80.80.7-0.70.0-0.60.5
Rest time, locomotor task time 20.10.10.8-0.90.5-0.30.30.3-0.20.20.1-0.10.1-0.10.0
Distance moved, locomotor task time 20.10.10.20.5-0.40.1-0.3-0.20.1-0.1-0.10.00.2-0.0-0.2
Vertical activity count, locomotor time 20.60.82.21.2-1.50.9-1.1-0.90.7-0.9-0.70.70.50.7-0.4
Light reinforcement 11.12.73.90.8-1.61.6-1.6-1.81.8-1.8-1.92.01.61.8-1.1
Light reinforcement 21.21.92.91.3-1.11.3-1.1-1.51.7-1.3-1.51.51.71.2-1.0
Bone: marrow area2.24.86.8-2.62.2-2.52.32.5-2.42.32.1-2.1-1.3-2.21.2
Bone: maximum diameter0.40.71.5-1.20.5-0.90.70.8-1.00.70.8-0.7-0.6-0.9-0.6
Bone: maximum force0.20.42.3-1.3-0.0-0.70.10.20.10.10.1-0.01.5-0.2-0.8
Bone: maximum moment0.30.52.1-1.40.2-1.00.40.5-0.10.40.3-0.21.4-0.4-0.6
Mean time between licks in bursts0.51.24.22.0-1.11.4-1.1-1.00.7-1.0-1.01.0-0.71.00.4
Mean num. licks in bursts3.04.78.2-2.92.5-2.32.42.3-2.12.32.0-2.0-1.3-2.11.4
Cd content in liver1.21.31.81.1-1.31.2-1.3-1.21.3-1.1-1.31.11.01.3-0.1
Co content in liver0.20.21.3-0.3-0.1-0.20.20.20.20.2-0.20.31.20.11.0
Cu content in liver0.30.44.10.40.10.10.10.5-0.30.10.00.0-0.50.22.0
Fe content in liver0.30.41.20.4-0.50.4-0.5-0.40.7-0.4-0.60.61.10.71.1
K content in liver1.21.21.8-1.01.1-1.41.21.3-1.01.21.2-1.20.2-1.30.4
Mg content in liver0.00.00.00.1-0.20.10.10.00.00.0-0.10.10.10.00.0
Mn content in liver1.01.13.0-0.21.2-0.71.20.8-1.11.11.0-0.9-1.7-1.20.7
Na content in liver0.50.61.2-1.10.7-1.00.80.9-0.60.90.6-0.60.2-0.60.8
Rb content in liver1.72.04.0-1.31.3-1.21.51.4-1.61.51.2-1.3-2.0-1.50.9
Se content in liver2.32.73.71.7-1.61.9-1.6-1.81.8-1.5-1.91.91.21.8-0.1
Sr content in liver0.70.61.1-0.20.8-0.90.90.9-0.80.91.0-0.9-0.5-0.90.2
Zn content in liver0.20.30.7-0.80.2-0.70.40.8-0.60.50.6-0.50.1-0.40.1
Bone: minimum diameter0.20.41.1-1.10.5-0.80.70.7-0.30.80.2-0.20.4-0.30.9
Time in familiar zone, hab. session 10.70.71.60.6-1.10.6-0.9-0.60.9-0.8-0.80.81.30.90.1
Time in novel zone, hab. session 10.50.51.0-0.51.0-0.60.80.6-0.70.80.7-0.7-0.7-0.8-0.0
Total zone transitions, hab. session 10.10.21.10.2-0.30.2-0.30.20.2-0.3-0.30.30.30.61.1
Total locomotion distance, hab. session 10.71.01.81.0-1.00.9-1.0-0.41.0-1.0-1.01.01.21.40.8
Locomotion velocity, hab. session 10.40.51.01.0-0.90.7-0.8-0.20.7-0.7-0.60.60.71.00.5
Time in familiar zone, hab. session 20.70.72.51.6-0.90.7-0.9-0.80.6-0.8-0.30.30.30.2-1.3
Time in novel zone, hab. session 20.70.72.9-1.70.9-0.70.80.7-0.60.80.2-0.1-0.1-0.01.6
Total zone transitions, hab. session 21.31.72.4-0.71.2-1.21.21.5-1.51.21.5-1.4-1.5-1.21.1
Total locomotion distance, hab. session 20.10.20.50.10.1-0.20.10.6-0.50.20.5-0.5-0.7-0.20.5
Locomotion velocity, hab. session 20.10.10.60.20.0-0.10.10.5-0.50.10.5-0.5-0.8-0.20.2
Novel to familiar place preference ratio0.20.21.3-0.1-0.20.5-0.2-0.2-0.2-0.3-0.20.3-1.10.3-0.5
Novelty place preference0.20.20.70.0-0.40.6-0.3-0.40.0-0.4-0.30.4-0.80.5-0.5
Time in novel zone, NPP test0.10.10.7-0.1-0.30.5-0.2-0.3-0.0-0.3-0.30.3-0.80.4-0.4
Total zone transitions, NPP test0.10.10.60.80.0-0.10.00.4-0.00.00.4-0.3-0.1-0.20.1
Total locomotion distance, NPP test0.20.31.50.70.4-0.20.40.6-0.10.30.5-0.40.2-0.21.2
Locomotion velocity, NPP test0.10.21.11.00.10.10.20.30.10.10.2-0.20.10.11.1
Intraocular pressure0.10.10.2-0.20.3-0.50.20.3-0.30.30.4-0.50.1-0.30.0
Delta distance traveled before/after self-admin0.30.30.7-0.50.8-0.50.50.6-0.40.70.3-0.5-0.3-0.50.7
Delta ambulatory time before/after self-admin0.00.00.1-0.20.30.1-0.1-0.00.20.1-0.40.20.20.10.4
Parametrial fat weight0.20.65.40.1-0.10.3-0.00.4-0.90.10.1-0.2-2.3-0.10.6
Pavlov. Cond. lever latency0.70.92.00.7-1.10.7-1.1-1.01.0-1.0-0.80.71.40.7-1.0
Pavlov. Cond. magazine entry latency0.30.42.00.10.70.10.70.3-0.50.60.1-0.0-1.4-0.20.8
Pavlov. Cond. change in total contacts1.31.41.9-1.01.2-1.11.31.4-1.41.31.0-1.1-1.3-1.01.3
Pavlov. Cond. index score1.11.42.0-1.01.4-1.01.41.3-1.31.30.9-0.9-1.4-0.91.4
Pavlov. Cond. latency score0.81.02.2-0.71.2-0.61.11.0-1.01.00.6-0.6-1.5-0.61.4
Pavlov. Cond. lever contacts1.11.32.4-1.01.3-0.91.31.2-1.11.20.8-0.7-1.3-0.71.6
Pavlov. Cond. magazine entry number0.30.31.10.2-0.70.2-0.7-0.40.6-0.7-0.20.21.10.3-0.9
Pavlov. Cond. intertrial magazine entries0.10.20.9-0.4-0.2-0.4-0.10.4-0.0-0.10.1-0.11.00.20.8
Pavlov. Cond. lever-magazine prob. diff.1.51.92.5-1.31.6-1.31.61.5-1.51.51.2-1.1-1.4-1.11.3
Pavlov. Cond. response bias0.60.71.2-0.51.0-0.61.00.8-0.81.00.5-0.5-1.1-0.61.0
Pavlov. Cond. lever latency0.30.51.81.0-0.50.7-0.4-0.70.1-0.4-0.10.1-1.1-0.0-1.3
Pavlov. Cond. magazine entry latency0.50.61.90.5-0.80.5-0.7-0.60.9-0.7-0.70.71.40.90.2
Pavlov. Cond. change in total contacts0.61.05.2-0.80.9-1.00.91.1-0.30.90.4-0.40.8-0.42.3
Pavlov. Cond. index score0.40.52.6-0.1-0.2-0.1-0.20.10.6-0.2-0.50.51.60.61.5
Pavlov. Cond. latency score0.40.53.0-0.0-0.2-0.0-0.2-0.00.7-0.2-0.50.51.70.61.4
Pavlov. Cond. lever contacts0.50.62.0-1.20.7-1.00.71.0-0.30.70.3-0.30.9-0.31.4
Pavlov. Cond. magazine entry number0.50.62.5-0.60.7-0.40.70.5-0.90.60.6-0.6-1.6-0.8-0.5
Pavlov. Cond. intertrial magazine entries0.10.11.10.50.10.30.0-0.1-0.10.1-0.20.2-1.00.00.5
Pavlov. Cond. lever-magazine prob. diff.0.60.83.70.2-0.50.2-0.4-0.20.9-0.4-0.80.81.90.91.5
Pavlov. Cond. response bias0.20.31.4-0.40.0-0.30.10.30.30.1-0.20.21.10.31.2
Time in closed arm before self-admin2.02.63.80.9-1.71.4-1.8-1.41.8-1.8-1.71.92.01.8-0.9
Time in closed arm after self-admin1.41.52.10.7-1.41.2-1.5-1.41.1-1.4-1.11.20.81.2-1.5
Time in open arm before self-admin1.51.63.5-1.11.2-1.01.40.9-1.51.31.4-1.5-1.9-1.30.5
Time in open arm after self-admin3.13.44.9-1.62.1-1.92.22.0-1.72.01.7-1.8-1.0-1.72.1
Bone: periosteal estimation0.61.33.1-1.81.0-1.51.21.4-1.11.21.1-0.90.1-1.10.3
Bone: periosteal perimeter0.30.51.2-1.10.3-1.00.60.7-0.50.60.6-0.50.9-0.6-0.3
Bone: post-yield work0.20.41.0-0.20.6-0.80.60.5-0.10.60.6-0.61.0-0.7-0.3
Progressive ratio test 1 active lever presses0.40.51.70.9-0.10.8-0.3-0.30.1-0.4-0.50.3-1.30.61.3
Progressive ratio test 1 breakpoint0.40.52.00.9-0.00.8-0.3-0.30.0-0.3-0.40.3-1.40.61.3
Progressive ratio test 1 inactive lever presses3.95.67.7-0.82.8-2.12.72.3-2.32.52.7-2.6-2.4-2.42.1
Progressive ratio test 2 active lever presses0.70.84.50.40.9-0.00.60.6-0.80.60.5-0.8-2.1-0.51.4
Progressive ratio test 2 breakpoint0.70.84.20.40.8-0.00.60.5-0.80.60.5-0.7-2.1-0.51.3
Progressive ratio test 2 inactive lever presses1.62.67.0-0.51.7-1.01.71.3-1.81.71.6-1.7-2.6-1.61.3
Incentive Sensitization - Responses1.92.74.5-0.42.0-1.21.91.5-1.71.81.6-1.9-2.1-1.81.3
Incentive Sensitization - Breakpoint1.82.43.7-0.41.8-1.21.71.4-1.61.71.5-1.8-1.9-1.71.2
Sum of active levers in priming session hrs 5-60.20.21.21.1-0.50.4-0.1-0.40.4-0.1-0.2-0.00.1-0.0-0.0
Progressive ratio0.10.21.4-0.10.2-0.20.50.3-0.00.2-0.00.00.30.11.2
Food seeking constrained by brief footshock1.21.52.61.4-1.31.6-1.4-1.21.1-1.1-1.41.50.01.30.0
Seeking ratio, punishment vs. effort0.81.11.81.0-1.11.3-1.4-1.10.9-1.1-1.11.1-0.11.0-0.9
Retroperitoneal fat weight1.35.48.2-2.92.1-2.32.32.3-2.72.22.4-2.4-2.6-2.4-0.0
Reaction time number correct0.10.30.9-1.00.4-0.50.50.6-0.70.30.4-0.4-0.7-0.30.3
Reaction time mean minus median0.20.55.1-0.1-0.30.1-0.3-0.70.4-0.30.00.00.7-0.2-2.2
Reaction time mean minus median AUC0.10.42.7-0.1-0.2-0.0-0.1-0.60.5-0.10.00.01.1-0.2-1.6
Reaction time num false alarms3.34.66.12.1-2.32.0-2.4-2.22.3-2.2-2.22.12.52.0-1.5
Reaction time num false alarms AUC2.94.69.31.9-2.21.7-2.3-2.02.4-2.1-2.01.93.11.9-1.6
Reaction time trials correct on left0.10.30.9-1.00.4-0.50.50.6-0.70.30.4-0.4-0.7-0.30.3
Reaction time trials on left0.10.20.7-0.80.3-0.30.30.5-0.60.20.2-0.3-0.6-0.10.1
Reaction time mean0.50.82.70.9-1.01.0-0.9-1.10.8-0.8-0.60.70.20.5-1.6
Reaction time mean AUC0.50.83.10.8-0.90.8-0.8-1.10.8-0.8-0.60.70.60.4-1.8
Median of all reaction times0.91.22.01.4-1.21.4-1.1-1.41.0-1.0-1.01.10.10.9-1.1
Reaction time omissions3.34.97.42.1-2.42.1-2.4-2.42.3-2.3-1.91.92.01.8-2.7
Reaction time false alarm rate3.24.58.12.2-2.11.8-2.3-2.12.4-2.1-2.01.92.91.9-1.3
Reaction time premature initiation rate0.30.40.70.4-0.70.8-0.8-0.70.4-0.7-0.60.7-0.40.7-0.4
Reaction time premature initiations0.10.10.7-0.4-0.30.2-0.4-0.1-0.2-0.3-0.10.2-0.80.3-0.5
Std. dev. reaction times0.20.33.0-0.1-0.20.1-0.1-0.40.1-0.10.2-0.10.1-0.3-1.7
Reaction time trials completed0.10.20.7-0.80.3-0.30.30.5-0.60.20.2-0.3-0.6-0.10.1
Reaction time trials AUC0.10.20.8-0.90.4-0.40.40.6-0.70.30.3-0.3-0.7-0.20.3
Run reversals in cocaine runway, females3.83.86.02.4-2.12.2-2.1-2.32.1-1.9-1.81.81.71.7-1.3
Run reversals in cocaine runway, males0.20.20.6-0.30.1-0.40.10.3-0.50.30.4-0.4-0.7-0.7-0.8
Latency to leave start box in cocaine runway1.61.84.61.6-1.71.3-1.4-1.31.0-1.6-0.90.90.31.0-2.2
Latency to leave start box in cocaine runway, F0.91.01.7-0.70.4-1.00.71.0-1.10.71.1-1.1-1.1-1.2-1.3
Latency to leave start box in cocaine runway, M10.49.712.53.5-3.33.4-3.4-3.33.2-3.5-3.13.12.03.3-1.8
Std. dev. time between licks in bursts0.20.30.50.3-0.70.4-0.6-0.50.3-0.7-0.40.50.00.5-0.6
Total sessions with >9 infusions0.20.20.90.4-0.40.6-0.4-0.2-0.1-0.3-0.40.4-0.90.40.7
Short access day 1 total inactive lever presses0.00.00.30.10.00.10.1-0.1-0.00.1-0.00.1-0.20.10.6
Short access day 10 total inactive lever presses0.71.83.2-1.01.4-1.51.31.3-1.31.31.7-1.8-1.0-1.5-0.1
Short access day 1 total infusions0.20.20.9-0.50.5-0.20.30.3-0.50.30.2-0.3-0.9-0.20.7
Short access day 10 total infusions0.10.11.0-0.10.00.2-0.1-0.0-0.3-0.1-0.2-0.0-1.00.30.6
Short access total infusions0.20.21.5-0.2-0.00.2-0.20.2-0.4-0.0-0.1-0.0-1.20.20.7
Short access day 1 locomotion0.10.10.8-0.30.2-0.10.20.1-0.50.30.4-0.5-0.9-0.30.1
Short access day 10 total locomotion0.20.31.2-0.10.1-0.20.30.6-0.80.40.5-0.4-1.1-0.21.1
Short access total locomotion0.40.50.80.7-0.90.9-0.8-0.50.2-0.6-0.60.7-0.70.80.8
One hour access (0.3 mA shock)0.60.72.90.11.0-0.20.80.3-0.80.80.5-0.9-1.7-0.70.9
Compulsive drug intake1.21.42.2-0.51.2-1.31.31.2-1.01.41.5-1.3-0.5-1.40.9
One hour access (shock baseline)0.20.40.90.7-0.20.9-0.5-0.50.3-0.5-0.80.5-0.90.60.3
Social response proportion0.10.10.20.10.4-0.10.30.1-0.20.20.2-0.1-0.4-0.3-0.1
Social responses0.10.20.9-0.50.1-0.50.10.2-0.00.20.4-0.40.9-0.3-0.6
Social time0.10.10.60.3-0.1-0.0-0.1-0.0-0.1-0.10.4-0.3-0.1-0.2-0.8
Soleus weight0.20.71.1-0.51.0-0.90.91.0-0.80.80.9-0.8-0.3-0.70.8
Bone: stiffness0.20.31.4-1.1-0.2-0.4-0.10.00.0-0.1-0.10.00.8-0.0-1.2
Tibialis anterior weight1.13.66.7-2.61.7-2.31.72.0-2.11.62.2-2.2-0.7-2.0-0.5
Time to tail flick, vehicle, before self-admin1.51.52.3-0.91.3-1.21.31.2-1.41.11.5-1.5-1.4-1.20.1
Time to tail flick, vehicle, after self-admin0.20.30.80.20.7-0.20.4-0.0-0.30.50.5-0.6-0.9-0.8-0.6
Time to tail flick, test, before self-admin1.21.33.50.7-1.01.1-1.2-1.41.1-1.3-0.90.90.81.0-1.9
Time to tail flick, test, after self-admin2.32.45.60.8-1.91.0-1.6-1.41.6-1.6-1.31.22.41.4-1.6
Delta time to tail flick, vehicle, before/after SA0.20.20.60.7-0.20.3-0.3-0.70.6-0.1-0.30.30.7-0.1-0.8
Delta time to tail flick, test, before/after SA0.10.10.70.1-0.6-0.0-0.20.20.2-0.2-0.30.20.80.30.5
Tibia length0.41.03.80.6-1.30.9-1.1-1.00.7-1.2-0.70.80.40.8-1.9
Ambulatory time before self-admin0.10.10.50.3-0.60.2-0.3-0.0-0.2-0.20.1-0.1-0.4-0.0-0.7
Ambulatory time after self-admin0.20.30.5-0.20.5-0.40.40.7-0.60.60.5-0.7-0.5-0.70.2
Bone: tissue strength0.50.51.7-0.5-0.40.2-0.6-0.70.7-0.6-0.60.71.30.5-0.9
Total heroin consumption0.20.31.61.2-0.70.5-0.4-0.40.4-0.5-0.20.10.30.40.2
Bone: trabecular number0.10.10.9-0.1-0.2-0.1-0.2-0.30.3-0.2-0.10.10.8-0.0-1.0
Bone: trabecular spacing0.10.10.6-0.50.3-0.30.20.5-0.30.20.2-0.20.0-0.10.8
Bone: trabecular thickness2.02.53.81.9-1.51.7-1.6-1.81.7-1.5-1.71.81.21.4-0.7
Bone: trabecular tissue density3.55.28.31.6-2.62.1-2.5-2.32.5-2.4-2.22.32.92.4-1.0
Water consumed over 24 hours0.60.82.4-1.61.0-1.20.90.7-0.60.90.7-0.80.4-0.9-0.2
Number of responses in last shaping day0.40.51.21.1-0.50.9-0.6-0.50.5-0.7-0.70.7-0.40.70.8