Hub : Genes

LOC134487042

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC134487042	0.02	0.02	7.0e-03	0	0	-0	-0	2.6e-01	1.2e-01	6.8e-01	3.8e-01
2	RMTg	gene expression	LOC134487042	0.21	0.15	4.8e-03	0.06	0.03	0.05	0.04	1.4e-02	5.6e-02	2.0e-02	3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.2	0.4	0.5	0.7	-0.5
Area under the delay curve	3.3	3.9	4.5	-1.8	2.1
BMI with tail	0.2	0.7	0.9	0.8	-0.9
BMI without tail	0.4	1.2	1.6	0.9	-1.3
Body weight	0.2	0.8	1.2	-1.1	0.7
Weight adjusted by age	0.2	0.3	0.4	-0.6	0.6
Bone surface	0.0	0.1	0.1	0.2	-0.3
Bone volume	0.0	0.0	0.0	0.0	-0.1
Breakpoint value in progressive ratio session	0.7	0.8	1.0	1.0	-0.9
Number of licking bursts	0.1	0.1	0.2	0.4	-0.3
Context. condit. distance diff. score	2.0	2.5	4.3	2.1	-0.8
Locomotion velocity, session 1	0.2	0.2	0.3	-0.2	0.6
Locomotion distance, session 1	0.0	0.0	0.1	0.2	0.3
Locomotion velocity, session 2	0.3	0.3	0.4	0.7	-0.4
Locomotion distance, session 2	0.0	0.0	0.0	0.2	0.1
Locomotion velocity, session 3	1.3	1.4	2.6	1.6	-0.6
Locomotion distance, session 3	1.6	1.7	2.7	1.6	-0.9
Stereotopy head waving bouts, day 3	0.4	0.4	0.7	0.9	-0.3
Stereotopy head waving duration, day 3	0.1	0.1	0.1	0.2	-0.3
Locomotion velocity, session 7	0.3	0.3	0.4	0.5	0.6
Locomotion distance, session 7	0.4	0.5	1.0	0.0	1.0
Stereotopy head waving bouts, day 7	2.4	2.6	3.9	2.0	-1.2
Stereotopy head waving duration, day 7	1.5	1.8	2.2	1.5	-1.2
Locomotion velocity, session 8	1.4	1.7	2.2	1.5	-1.1
Locomotion distance, session 8	2.4	3.5	5.4	2.3	-1.3
Degree of sensitization distance	0.8	0.8	0.9	-0.9	0.9
Degree of sensitization stereotypy	0.9	0.9	1.6	1.3	-0.6
Conditioned locomotion	0.2	0.2	0.4	-0.6	-0.2
Cocaine response after cond. corrected	0.4	0.5	0.7	-0.9	0.6
Cocaine response after cond. not corrected	0.8	1.0	1.0	-1.0	1.0
Cocaine response before conditioning	0.1	0.1	0.3	-0.1	0.5
Saline control response	0.1	0.2	0.3	-0.6	0.0
Bone: connectivity density	0.7	1.1	1.3	1.1	-0.9
Bone: cortical apparent density	0.7	0.9	1.6	-1.3	0.5
Bone: cortical area	0.8	1.2	1.9	-1.4	0.7
Bone: cortical porosity	1.0	1.1	1.6	-0.7	1.3
Bone: cortical porosity	0.4	0.4	0.6	-0.4	0.8
Bone: cortical thickness	0.8	1.3	1.5	-1.2	1.1
Bone: cortical thickness	0.4	0.5	0.9	-0.3	1.0
Bone: cortical tissue density	0.6	0.8	1.4	-1.2	0.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.5	0.2
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.4	-1.1	1.2
Condit. Reinf. active responses	1.0	1.2	2.4	1.5	-0.3
Condit. Reinf. inactive responses	5.7	6.9	10.5	3.2	-1.8
Incentive salience index mean	0.2	0.2	0.4	-0.3	0.6
Condit. Reinf. lever presses	0.3	0.4	0.5	-0.7	0.4
Condit. Reinf. active minus inactive responses	1.2	1.5	2.5	1.6	-0.7
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.8	0.9	-0.0
Condit. Reinf. active responses	1.2	1.7	2.3	1.5	-1.1
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.0	-0.3
Condit. Reinf. lever presses	0.2	0.3	0.4	0.7	-0.4
Condit. Reinf. lever reinforcers received	1.0	1.3	1.9	1.4	-0.9
Conditioned reinforcement - actives	0.1	0.1	0.2	0.5	-0.2
Conditioned reinforcement - inactives	1.0	1.5	1.9	-1.4	1.0
Conditioned locomotion	0.3	0.3	0.7	0.8	-0.1
Patch foraging indifference point 0 sec	1.5	2.8	3.8	-1.9	1.4
Patch foraging indifference point AUC	0.1	0.1	0.2	0.1	0.4
Delay disc. indifference point, 0s delay	2.3	2.5	4.0	-1.0	2.0
Delay disc. indifference point, 16s delay	1.1	1.3	1.4	-1.2	1.0
Delay disc. indifference point, 2s delay	0.8	0.9	1.1	-0.8	1.1
Delay disc. indifference point, 24s delay	3.5	3.9	6.2	-2.5	1.3
Delay disc. indifference point, 4s delay	4.4	4.6	5.3	-2.0	2.3
Delay disc. indifference point, 8s delay	3.2	3.8	4.8	-1.7	2.2
Indifference point function ln k	0.2	0.4	0.8	-0.9	-0.1
Indifference point function log k	0.2	0.4	0.8	-0.9	-0.1
Patch foraging total patch changes 0 sec	1.2	2.3	3.2	-1.8	1.2
Patch foraging total patch changes 12 sec	0.4	0.6	0.9	-0.5	0.9
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	-0.7	0.3
Patch foraging total patch changes 24 sec	0.0	0.1	0.1	-0.3	0.2
Patch foraging total patch changes 6 sec	0.7	1.1	1.4	-1.2	0.9
Patch foraging time to switch 0 sec	0.0	0.0	0.0	-0.1	0.1
Patch foraging water rate 0 sec	0.0	0.0	0.1	0.1	-0.2
Patch foraging water rate 12 sec	0.2	0.5	0.5	0.6	-0.7
Patch foraging water rate 18 sec	1.4	2.1	2.4	1.5	-1.3
Patch foraging water rate 24 sec	0.2	0.3	0.6	0.7	-0.1
Patch foraging water rate 6 sec	0.2	0.4	0.7	0.8	-0.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.1	-0.3
Distance traveled before self-admin	3.9	5.1	5.6	2.4	-2.1
Distance traveled after self-admin	0.1	0.1	0.1	0.4	-0.4
Extensor digitorum longus weight	0.2	0.9	1.5	1.2	-0.6
Bone: elastic displacement	2.9	3.4	4.0	1.7	-2.0
Bone: elastic work	1.0	1.3	1.9	1.4	-0.8
Bone: endosteal estimation	0.1	0.2	0.3	-0.2	-0.6
Bone: endosteal perimeter	0.0	0.1	0.2	-0.4	-0.1
Epididymis fat weight	2.2	7.5	8.1	-2.8	2.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.3	0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.5	0.0
Diff in mean of infusions in LGA sessions	0.1	0.2	0.2	-0.3	-0.5
Delay discount exponential model param	3.8	4.2	4.6	2.0	-2.1
Extinction: sum of active levers before priming	0.3	0.3	0.3	-0.6	0.5
Active lever presses in extinction session 6	0.1	0.1	0.2	0.2	-0.4
Bone: final force	0.9	1.4	1.4	-1.2	1.2
Bone: final moment	0.6	1.0	1.2	-0.9	1.1
Food consumed during 24 hour testing period	0.1	0.1	0.3	0.2	0.5
Glucose	0.2	0.3	0.5	0.3	0.7
Heart weight	15.3	23.7	27.1	5.2	-4.5
Delay discount hyperbolic model param	3.8	4.3	4.7	2.0	-2.2
Intermittent access intake day 1-15 change	0.1	0.3	0.4	0.7	0.4
Intermittent access intake escalation	0.2	0.4	0.7	0.8	0.1
Intermittent access intake escalation 2	0.7	0.8	1.7	1.3	-0.1
Intermitt. access day 1 inactive lever presses	0.2	0.8	0.8	-0.9	0.9
Intermitt. access day 15 inactive lever presses	0.2	0.4	0.8	0.9	0.1
Intermitt. access escalation Index	1.9	2.7	3.0	1.7	-1.5
Intermittent access day 1 total infusions	0.2	0.4	0.6	-0.8	0.4
Intermittent access day 15 total infusions	0.2	0.3	0.6	-0.1	0.8
Intermittent access terminal intake (last 3 days)	0.7	0.9	1.3	-0.7	1.2
Intermittent access total infusions	1.5	1.8	1.8	-1.4	1.3
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.3	-0.3
Intermittent access day 15 total locomotion	0.0	0.1	0.1	0.3	0.3
Intermittent access total locomotion	0.0	0.0	0.0	-0.1	0.1
Intermittent access standard deviation	0.3	0.7	0.9	-0.7	1.0
Left kidney weight	0.2	1.1	1.4	1.2	-0.9
Right kidney weight	0.0	0.2	0.3	0.5	-0.4
Cocaine induced anxiety	0.1	0.1	0.2	-0.4	-0.1
Post-drug Anxiety	0.2	0.3	0.3	0.4	-0.6
Baseline Anxiety	0.3	0.3	0.4	0.6	-0.5
Tail length	0.7	2.8	3.7	-1.9	1.3
Length with tail	1.3	5.5	6.8	-2.6	2.1
Length without tail	0.5	1.5	2.0	-1.4	1.0
Times rat made contact with spout	0.0	0.1	0.1	0.3	-0.0
Lifetime Intake	1.0	1.2	1.4	-1.2	1.1
Liver weight, left	4.5	7.5	7.9	-2.7	2.8
Liver weight, right	4.2	7.3	10.0	-2.1	3.2
Locomotor activity	1.3	2.0	2.1	1.4	-1.4
Locomotor testing distance	2.1	3.9	4.3	2.1	-1.8
Locomotor testing rearing	0.5	1.0	1.2	1.1	-0.9
Locomotion in novel chamber	1.8	2.3	3.1	1.8	-1.2
Locomotion in novel chamber post-restriction	0.8	1.4	1.5	1.1	-1.2
Fecal boli incidents, locomotor time 1	7.0	10.1	13.7	-2.6	3.7
Change in fecal boli incidents, locomotor task	1.2	1.2	1.7	0.8	-1.3
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.5	0.4	-0.7
Bouts of movement, locomotor time 1	1.5	1.7	1.8	-1.3	1.4
Total resting periods, locomotor time 1	1.4	1.5	1.7	-1.3	1.2
Rest time, locomotor task time 1	0.9	1.1	1.3	1.2	-1.0
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.3	-0.3
Vertical activity count, locomotor time 1	1.3	3.1	4.7	1.2	-2.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.5	0.2
Bouts of movement, locomotor time 2	0.3	0.4	0.7	-0.8	0.4
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.5	-0.1
Rest time, locomotor task time 2	3.1	4.0	4.8	1.8	-2.2
Distance moved, locomotor task time 2	0.6	0.7	1.0	-0.6	1.0
Vertical activity count, locomotor time 2	0.3	0.4	0.6	0.8	-0.5
Light reinforcement 1	0.2	0.5	1.0	1.0	-0.1
Light reinforcement 2	0.1	0.1	0.1	-0.3	-0.3
Bone: marrow area	0.1	0.2	0.3	-0.2	-0.5
Bone: maximum diameter	0.3	0.6	1.2	-1.1	0.3
Bone: maximum force	0.5	0.8	0.9	-1.0	0.9
Bone: maximum moment	0.2	0.4	0.5	-0.6	0.7
Mean time between licks in bursts	0.0	0.1	0.1	-0.1	-0.3
Mean num. licks in bursts	0.1	0.1	0.2	-0.3	0.4
Cd content in liver	0.0	0.0	0.0	-0.1	-0.1
Co content in liver	0.1	0.1	0.3	0.5	0.2
Cu content in liver	0.1	0.1	0.1	0.0	-0.4
Fe content in liver	0.5	0.6	0.9	0.6	-1.0
K content in liver	0.5	0.5	0.5	0.7	-0.7
Mg content in liver	0.0	0.0	0.1	-0.1	-0.3
Mn content in liver	0.7	0.8	1.0	0.7	-1.0
Na content in liver	1.2	1.3	2.3	0.5	-1.5
Rb content in liver	0.5	0.6	1.0	0.4	-1.0
Se content in liver	0.1	0.2	0.3	-0.5	-0.1
Sr content in liver	0.1	0.1	0.1	0.0	-0.3
Zn content in liver	3.6	4.0	4.8	-1.8	2.2
Bone: minimum diameter	0.5	0.8	1.5	-1.2	0.4
Time in familiar zone, hab. session 1	0.1	0.1	0.1	0.4	0.1
Time in novel zone, hab. session 1	0.5	0.5	1.0	-1.0	0.1
Total zone transitions, hab. session 1	0.1	0.2	0.3	0.2	-0.6
Total locomotion distance, hab. session 1	0.2	0.3	0.5	-0.1	0.7
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.2	0.5
Time in familiar zone, hab. session 2	3.2	3.4	4.8	1.4	-2.2
Time in novel zone, hab. session 2	1.1	1.2	2.0	-0.5	1.4
Total zone transitions, hab. session 2	3.7	4.7	5.3	2.0	-2.3
Total locomotion distance, hab. session 2	1.5	2.0	3.2	1.8	-0.9
Locomotion velocity, hab. session 2	1.0	1.3	2.2	1.5	-0.6
Novel to familiar place preference ratio	0.2	0.2	0.3	-0.1	0.6
Novelty place preference	0.1	0.1	0.2	-0.1	0.5
Time in novel zone, NPP test	0.1	0.1	0.2	-0.1	0.5
Total zone transitions, NPP test	0.2	0.2	0.3	0.3	-0.6
Total locomotion distance, NPP test	0.2	0.2	0.5	0.7	0.0
Locomotion velocity, NPP test	0.2	0.3	0.5	0.7	0.1
Intraocular pressure	0.1	0.1	0.3	0.5	0.1
Delta distance traveled before/after self-admin	2.8	3.0	3.5	-1.9	1.6
Delta ambulatory time before/after self-admin	2.3	2.8	3.4	-1.8	1.5
Parametrial fat weight	1.6	3.8	6.3	-1.2	2.5
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.7	-0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	-0.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. index score	0.4	0.5	0.9	-0.9	0.4
Pavlov. Cond. latency score	0.3	0.4	0.7	-0.8	0.3
Pavlov. Cond. lever contacts	0.3	0.4	0.4	-0.6	0.6
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	0.3
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.2	0.6	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.3	-1.1	0.5
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.2	-0.1
Pavlov. Cond. lever latency	1.5	2.1	3.0	-1.7	1.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	0.1
Pavlov. Cond. change in total contacts	0.6	0.9	1.2	1.1	-0.8
Pavlov. Cond. index score	0.3	0.4	0.7	0.8	-0.4
Pavlov. Cond. latency score	0.3	0.4	0.6	0.8	-0.4
Pavlov. Cond. lever contacts	1.3	1.9	2.6	1.6	-1.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.4	0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.8	0.9	-0.5
Pavlov. Cond. response bias	0.8	1.1	1.8	1.3	-0.6
Time in closed arm before self-admin	0.2	0.2	0.4	0.7	-0.1
Time in closed arm after self-admin	0.5	0.5	0.6	-0.7	0.8
Time in open arm before self-admin	0.1	0.2	0.3	-0.6	0.1
Time in open arm after self-admin	1.0	1.1	1.2	1.1	-1.0
Bone: periosteal estimation	0.4	0.7	1.4	-1.2	0.3
Bone: periosteal perimeter	0.2	0.3	0.5	-0.7	0.2
Bone: post-yield work	1.0	1.4	1.4	-1.2	1.2
Progressive ratio test 1 active lever presses	0.1	0.2	0.2	-0.3	-0.5
Progressive ratio test 1 breakpoint	0.1	0.2	0.2	-0.4	-0.5
Progressive ratio test 1 inactive lever presses	0.5	0.7	1.2	-1.1	0.5
Progressive ratio test 2 active lever presses	0.8	1.0	1.3	-1.1	0.8
Progressive ratio test 2 breakpoint	0.8	0.9	1.3	-1.1	0.7
Progressive ratio test 2 inactive lever presses	0.7	1.2	1.5	-1.2	0.9
Incentive Sensitization - Responses	1.2	1.7	2.4	-1.6	1.0
Incentive Sensitization - Breakpoint	1.5	1.9	2.6	-1.6	1.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.3	-0.2
Progressive ratio	0.1	0.2	0.2	-0.4	-0.4
Food seeking constrained by brief footshock	2.1	2.6	3.6	1.9	-1.3
Seeking ratio, punishment vs. effort	0.4	0.6	1.0	1.0	-0.4
Retroperitoneal fat weight	0.1	0.4	0.6	0.8	-0.5
Reaction time number correct	0.1	0.2	0.4	0.6	0.1
Reaction time mean minus median	0.7	1.8	2.3	-1.5	1.2
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.3	0.1
Reaction time num false alarms	1.3	1.9	1.9	1.4	-1.3
Reaction time num false alarms AUC	2.1	3.3	3.4	1.9	-1.8
Reaction time trials correct on left	0.1	0.2	0.4	0.6	0.1
Reaction time trials on left	0.1	0.2	0.3	0.6	0.1
Reaction time mean	1.0	1.6	2.4	-1.5	0.9
Reaction time mean AUC	0.9	1.5	2.2	-1.5	0.9
Median of all reaction times	0.9	1.3	1.8	-1.3	0.9
Reaction time omissions	0.4	0.6	0.9	-1.0	0.5
Reaction time false alarm rate	1.2	1.7	1.9	1.2	-1.4
Reaction time premature initiation rate	0.6	0.8	1.1	-0.7	1.1
Reaction time premature initiations	0.4	0.7	1.2	-0.4	1.1
Std. dev. reaction times	1.0	1.9	2.5	-1.6	1.1
Reaction time trials completed	0.1	0.2	0.3	0.6	0.1
Reaction time trials AUC	0.1	0.1	0.3	0.5	0.2
Run reversals in cocaine runway, females	0.4	0.4	0.7	0.3	-0.8
Run reversals in cocaine runway, males	1.7	1.7	2.3	1.5	-1.1
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.5	0.0
Latency to leave start box in cocaine runway, F	0.5	0.6	0.6	-0.7	0.8
Latency to leave start box in cocaine runway, M	0.5	0.5	1.0	0.0	-1.0
Std. dev. time between licks in bursts	0.6	0.8	0.9	0.8	-1.0
Total sessions with >9 infusions	0.0	0.0	0.1	-0.2	-0.2
Short access day 1 total inactive lever presses	0.0	0.1	0.1	-0.3	0.2
Short access day 10 total inactive lever presses	0.2	0.5	0.7	-0.8	0.6
Short access day 1 total infusions	0.2	0.2	0.4	0.1	-0.7
Short access day 10 total infusions	0.2	0.3	0.6	-0.8	0.2
Short access total infusions	0.4	0.5	0.8	-0.9	0.4
Short access day 1 locomotion	0.1	0.1	0.1	-0.3	-0.3
Short access day 10 total locomotion	0.8	1.5	2.1	1.0	-1.4
Short access total locomotion	0.6	0.7	0.9	0.7	-1.0
One hour access (0.3 mA shock)	0.8	0.9	1.1	-0.9	1.0
Compulsive drug intake	1.8	2.1	2.5	1.3	-1.6
One hour access (shock baseline)	2.1	3.3	4.1	-1.6	2.0
Social response proportion	0.2	0.3	0.4	-0.6	0.3
Social responses	0.2	0.2	0.5	-0.0	0.7
Social time	0.2	0.2	0.4	0.7	-0.1
Soleus weight	0.2	0.7	1.4	1.2	-0.2
Bone: stiffness	0.8	1.3	1.4	-1.2	1.1
Tibialis anterior weight	0.1	0.3	0.5	-0.4	0.7
Time to tail flick, vehicle, before self-admin	2.3	2.4	2.5	1.5	-1.6
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.1	-0.2	-0.3
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.2	-0.6
Time to tail flick, test, after self-admin	2.8	2.9	3.4	1.9	-1.6
Delta time to tail flick, vehicle, before/after SA	2.1	2.0	2.4	-1.5	1.3
Delta time to tail flick, test, before/after SA	0.5	0.5	0.8	0.9	-0.5
Tibia length	0.4	1.0	1.8	-1.4	0.5
Ambulatory time before self-admin	2.5	3.7	4.1	2.0	-1.8
Ambulatory time after self-admin	0.2	0.2	0.2	0.5	-0.5
Bone: tissue strength	0.1	0.1	0.1	-0.3	0.3
Total heroin consumption	0.0	0.1	0.1	-0.3	-0.1
Bone: trabecular number	0.5	0.8	1.0	1.0	-0.8
Bone: trabecular spacing	0.4	0.6	0.8	-0.9	0.6
Bone: trabecular thickness	0.1	0.1	0.1	0.4	0.0
Bone: trabecular tissue density	0.7	1.0	1.2	-1.1	0.9
Water consumed over 24 hours	0.6	0.8	1.2	1.1	-0.7
Number of responses in last shaping day	0.3	0.3	0.6	-0.8	0.3