LOC134486925

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	LOC134486925	0.65	0.24	1.4e-15	0.27	0.28	0.28	0.28	1.8e-14	2.5e-15	2.7e-15	4.0e-15
2	PL	gene expression	LOC134486925	0.47	0	0.0e+00	0.24	0.22	0.23	0.24	1.2e-25	3.8e-24	2.7e-25	8.2e-26
3	Brain	gene expression	LOC134486925	0.4	0.15	0.0e+00	0.24	0.24	0.24	0.24	1.2e-22	1.1e-22	1.2e-22	9.6e-23
4	NAcc	gene expression	LOC134486925	0.28	0.11	0.0e+00	0.28	0.28	0.28	0.29	3.5e-43	6.1e-43	1.7e-42	6.9e-44
5	RMTg	gene expression	LOC134486925	0.29	0.16	4.6e-05	0.18	0.19	0.24	0.21	1.4e-05	1.1e-05	5.7e-07	2.4e-06
6	Adipose	gene expression	LOC134486925	0.06	0.05	1.8e-05	0.03	0.03	0.03	0.02	7.2e-04	7.7e-04	5.4e-04	1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.8	1.5	2.4	1.2	1.2	1.2	1.0	-1.6	-1.3
Area under the delay curve	0.1	0.2	0.4	0.4	0.4	0.3	0.4	0.4	-0.7
BMI with tail	2.5	8.7	11.7	3.4	3.4	3.4	3.3	-1.4	-2.1
BMI without tail	1.6	8.8	10.3	3.2	3.2	3.1	3.0	-2.4	-2.8
Body weight	7.4	32.2	37.3	6.1	6.0	6.0	5.9	-4.7	-5.1
Weight adjusted by age	0.6	1.8	4.0	1.2	1.3	1.2	1.1	-2.0	-0.9
Bone surface	2.0	3.9	5.9	1.8	1.7	1.7	1.7	-2.4	-2.3
Bone volume	1.1	2.2	3.7	1.3	1.3	1.3	1.1	-1.9	-1.8
Breakpoint value in progressive ratio session	0.2	0.3	0.9	-0.3	-0.6	-0.7	-0.2	0.9	-0.2
Number of licking bursts	0.1	0.2	0.2	-0.5	-0.5	-0.4	-0.4	-0.4	0.4
Context. condit. distance diff. score	0.9	1.0	1.7	-0.9	-0.9	-0.9	-0.9	1.3	1.1
Locomotion velocity, session 1	0.3	0.3	0.7	-0.6	-0.5	-0.5	-0.5	0.4	0.8
Locomotion distance, session 1	2.4	3.0	3.4	-1.8	-1.8	-1.8	-1.7	1.5	1.7
Locomotion velocity, session 2	0.2	0.2	0.4	0.6	0.6	0.5	0.6	-0.2	-0.0
Locomotion distance, session 2	4.3	6.1	7.8	-2.4	-2.3	-2.3	-2.3	2.8	2.7
Locomotion velocity, session 3	1.9	2.2	3.6	-1.4	-1.3	-1.3	-1.3	1.7	1.9
Locomotion distance, session 3	2.0	2.3	4.5	-1.3	-1.2	-1.2	-1.2	2.1	1.9
Stereotopy head waving bouts, day 3	0.8	0.9	1.5	0.8	0.9	0.9	0.7	-1.1	-1.2
Stereotopy head waving duration, day 3	1.4	1.8	2.2	1.4	1.5	1.5	1.3	-1.2	-1.0
Locomotion velocity, session 7	0.4	0.5	1.4	-0.3	-0.3	-0.2	-0.2	1.0	1.2
Locomotion distance, session 7	1.0	1.3	2.7	-0.9	-0.9	-0.9	-0.8	1.6	1.5
Stereotopy head waving bouts, day 7	0.4	0.5	0.8	0.8	0.9	0.9	0.7	0.0	0.1
Stereotopy head waving duration, day 7	1.7	2.1	3.1	1.7	1.8	1.7	1.6	-0.7	-0.7
Locomotion velocity, session 8	4.3	5.2	9.7	-1.9	-1.9	-1.9	-1.8	3.1	2.8
Locomotion distance, session 8	5.3	7.7	9.6	-2.7	-2.7	-2.6	-2.5	3.1	3.1
Degree of sensitization distance	0.3	0.3	0.4	0.6	0.6	0.6	0.7	-0.2	-0.3
Degree of sensitization stereotypy	0.5	0.6	0.9	0.9	0.9	0.9	0.8	0.5	0.5
Conditioned locomotion	0.2	0.2	0.7	0.4	0.3	0.3	0.3	-0.6	-0.8
Cocaine response after cond. corrected	0.4	0.6	0.7	0.7	0.7	0.8	0.7	-0.7	-0.9
Cocaine response after cond. not corrected	0.5	0.7	1.0	0.7	0.7	0.8	0.7	-1.0	-0.9
Cocaine response before conditioning	0.2	0.2	0.5	0.4	0.5	0.5	0.3	-0.7	-0.1
Saline control response	1.0	1.4	2.3	1.1	1.1	1.0	1.0	-1.2	-1.5
Bone: connectivity density	1.0	1.6	1.8	1.3	1.3	1.2	1.2	-1.3	-1.3
Bone: cortical apparent density	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	-0.1	0.0
Bone: cortical area	4.7	7.6	8.7	2.8	2.8	2.8	2.7	-3.0	-2.6
Bone: cortical porosity	0.7	0.7	2.3	0.3	0.3	0.3	0.3	-1.3	-1.5
Bone: cortical porosity	1.5	1.7	3.2	1.0	1.0	1.0	1.0	-1.6	-1.8
Bone: cortical thickness	1.6	2.7	4.0	1.6	1.6	1.6	1.5	-2.0	-1.5
Bone: cortical thickness	0.3	0.4	0.5	0.6	0.6	0.7	0.7	-0.7	0.3
Bone: cortical tissue density	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.4	-0.1	0.1
Condit. Reinf. active minus inactive responses	2.3	2.6	3.7	-1.6	-1.6	-1.6	-1.6	1.3	1.9
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.0	-0.8	-0.8	-0.8	-0.8	0.3	1.0
Condit. Reinf. active responses	1.6	2.0	2.9	-1.4	-1.3	-1.3	-1.3	1.4	1.7
Condit. Reinf. inactive responses	1.1	1.5	2.7	-1.1	-1.1	-1.1	-1.1	1.6	1.2
Incentive salience index mean	0.6	0.8	1.5	-0.9	-0.8	-0.8	-0.8	0.7	1.2
Condit. Reinf. lever presses	0.0	0.1	0.1	0.2	0.2	0.2	0.3	0.1	0.4
Condit. Reinf. active minus inactive responses	1.9	3.0	3.9	2.0	2.0	1.9	1.9	-0.8	-1.5
Condit. Reinf. active-inactive response ratio	0.5	0.7	1.1	1.0	1.1	1.0	1.0	0.3	0.2
Condit. Reinf. active responses	3.3	4.8	6.9	2.2	2.2	2.2	2.1	-1.6	-2.6
Condit. Reinf. inactive responses	2.2	3.3	8.0	1.6	1.6	1.5	1.4	-1.5	-2.8
Condit. Reinf. lever presses	2.4	3.4	4.0	1.9	1.9	2.0	1.8	-1.8	-1.7
Condit. Reinf. lever reinforcers received	3.7	5.1	7.1	2.3	2.3	2.3	2.2	-1.8	-2.7
Conditioned reinforcement - actives	0.1	0.5	0.7	0.8	0.8	0.8	0.7	-0.5	-0.5
Conditioned reinforcement - inactives	0.4	1.1	1.5	1.1	1.2	1.2	1.0	-1.1	-0.7
Conditioned locomotion	0.5	0.8	1.0	0.9	0.9	1.0	0.9	-0.9	-0.6
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.5	0.3	0.3	0.4	-0.4	-0.7
Patch foraging indifference point AUC	0.6	1.5	1.8	1.3	1.2	1.2	1.4	-1.0	-1.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.2	-0.2	-0.1	-0.2	0.4	0.4
Delay disc. indifference point, 16s delay	1.0	1.4	1.9	1.3	1.2	1.1	1.4	-0.4	-1.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.7	0.3	0.3	0.3	0.2	-0.3	-0.8
Delay disc. indifference point, 24s delay	0.4	0.7	1.0	1.0	1.0	0.8	0.9	-0.2	-0.7
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	-0.3	-0.4	-0.3	-0.2	0.7	-0.1
Delay disc. indifference point, 8s delay	0.1	0.2	0.6	0.2	0.3	0.1	0.2	0.3	-0.8
Indifference point function ln k	0.1	0.4	0.6	-0.6	-0.6	-0.6	-0.6	0.5	0.8
Indifference point function log k	0.1	0.4	0.6	-0.6	-0.6	-0.6	-0.6	0.5	0.8
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.5	0.4	0.4	0.5	-0.3	-0.6
Patch foraging total patch changes 12 sec	0.7	1.0	1.6	1.2	1.1	1.1	1.3	-0.0	-0.7
Patch foraging total patch changes 18 sec	0.1	0.3	1.0	0.5	0.4	0.4	0.5	-1.0	-0.5
Patch foraging total patch changes 24 sec	0.2	0.8	1.3	0.8	0.7	0.7	0.9	-1.0	-1.1
Patch foraging total patch changes 6 sec	0.3	0.4	0.9	0.7	0.5	0.5	0.8	-0.5	-1.0
Patch foraging time to switch 0 sec	0.5	2.0	2.6	-1.5	-1.5	-1.6	-1.4	1.2	1.1
Patch foraging water rate 0 sec	1.0	3.9	4.4	2.0	2.0	2.1	1.9	-2.0	-1.8
Patch foraging water rate 12 sec	0.7	2.9	3.9	1.7	1.9	2.0	1.6	-1.7	-1.4
Patch foraging water rate 18 sec	0.8	1.7	2.7	1.5	1.7	1.6	1.5	-0.4	-0.6
Patch foraging water rate 24 sec	0.3	0.4	0.8	0.6	0.9	0.9	0.7	0.3	-0.1
Patch foraging water rate 6 sec	1.4	2.1	3.1	1.4	1.7	1.7	1.4	-1.4	-0.8
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.2	0.2	0.0	0.1	0.3	-0.2	-0.5
Distance traveled before self-admin	0.2	0.3	0.6	-0.6	-0.4	-0.5	-0.6	0.6	0.8
Distance traveled after self-admin	0.1	0.1	0.2	0.2	0.4	0.4	0.1	-0.3	0.2
Extensor digitorum longus weight	5.3	21.2	23.8	4.9	4.8	4.8	4.8	-4.4	-3.9
Bone: elastic displacement	0.2	0.3	0.4	-0.6	-0.6	-0.6	-0.5	-0.5	-0.1
Bone: elastic work	1.4	1.8	4.1	1.0	1.0	1.0	1.0	-2.0	-1.6
Bone: endosteal estimation	3.6	8.8	10.1	3.2	3.1	3.1	3.1	-2.7	-2.6
Bone: endosteal perimeter	1.5	3.7	3.8	1.9	1.9	1.9	1.9	-1.9	-1.9
Epididymis fat weight	0.1	0.6	1.2	-0.7	-0.8	-0.7	-0.7	1.1	-0.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	-0.6	-0.4	-0.6	-0.7	0.4	0.6
Delta time in open arm before/after self-admin	0.2	0.3	0.5	0.5	0.3	0.4	0.6	0.7	-0.4
Diff in mean of infusions in LGA sessions	1.8	3.2	4.4	-1.7	-2.1	-2.1	-1.5	2.1	1.1
Delay discount exponential model param	0.1	0.1	0.3	-0.2	-0.2	-0.1	-0.3	-0.6	0.5
Extinction: sum of active levers before priming	1.0	1.6	2.7	-1.2	-1.1	-1.0	-1.2	1.4	1.6
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.3	-0.4	-0.5	-0.2	0.6	-0.1
Bone: final force	1.8	2.9	3.5	1.7	1.7	1.6	1.6	-1.9	-1.7
Bone: final moment	2.9	4.7	5.4	2.2	2.1	2.1	2.0	-2.3	-2.2
Food consumed during 24 hour testing period	1.7	3.5	4.5	1.9	1.8	1.8	1.9	-2.1	-1.6
Glucose	0.1	0.1	0.2	0.4	0.4	0.4	0.3	-0.4	-0.2
Heart weight	3.2	5.1	6.0	2.2	2.3	2.5	2.2	-2.2	-2.1
Delay discount hyperbolic model param	0.1	0.1	0.4	-0.3	-0.3	-0.2	-0.3	-0.3	0.6
Intermittent access intake day 1-15 change	0.1	0.4	0.7	-0.6	-0.6	-0.5	-0.6	0.3	0.8
Intermittent access intake escalation	0.1	0.3	0.4	-0.6	-0.5	-0.5	-0.6	0.2	0.7
Intermittent access intake escalation 2	0.2	0.4	1.1	-0.5	-0.5	-0.5	-0.4	0.7	1.0
Intermitt. access day 1 inactive lever presses	0.0	0.4	1.1	-0.5	-0.4	-0.3	-0.6	0.7	1.0
Intermitt. access day 15 inactive lever presses	0.2	1.1	1.7	0.9	1.0	1.0	0.8	-1.3	-1.1
Intermitt. access escalation Index	0.1	0.3	0.5	-0.6	-0.7	-0.7	-0.5	0.2	-0.3
Intermittent access day 1 total infusions	1.0	2.9	3.3	1.8	1.8	1.8	1.8	-1.4	-1.6
Intermittent access day 15 total infusions	0.5	1.3	1.6	1.2	1.3	1.3	1.2	-0.9	-0.7
Intermittent access terminal intake (last 3 days)	0.6	1.1	1.5	1.2	1.1	1.1	1.2	-0.9	-0.6
Intermittent access total infusions	2.9	3.4	4.5	2.1	2.0	2.0	2.1	-1.3	-1.4
Intermittent access day 1 locomotion	0.5	0.9	1.6	0.8	0.8	0.8	0.8	-1.3	-1.2
Intermittent access day 15 total locomotion	0.4	1.4	3.2	1.0	1.0	1.0	1.0	-1.8	-1.2
Intermittent access total locomotion	0.8	1.0	1.7	0.9	0.8	0.8	0.9	-1.3	-1.1
Intermittent access standard deviation	0.1	0.8	1.2	1.1	1.1	1.0	1.1	0.1	-0.3
Left kidney weight	1.5	11.9	14.0	3.7	3.7	3.6	3.5	-3.2	-2.8
Right kidney weight	2.4	16.9	19.0	4.4	4.3	4.3	4.1	-3.9	-3.7
Cocaine induced anxiety	1.1	2.9	4.3	-1.5	-1.5	-1.6	-1.6	1.9	2.1
Post-drug Anxiety	0.3	0.3	0.8	-0.5	-0.4	-0.5	-0.5	0.4	0.9
Baseline Anxiety	0.4	0.6	1.3	0.6	0.6	0.6	0.7	-1.2	-0.9
Tail length	2.1	11.0	17.9	3.0	2.9	2.9	2.8	-4.2	-3.8
Length with tail	4.7	20.7	26.4	4.5	4.3	4.4	4.3	-5.1	-4.7
Length without tail	1.6	8.1	9.5	3.1	3.0	3.0	3.0	-2.4	-2.6
Times rat made contact with spout	0.4	0.5	1.4	0.5	0.5	0.5	0.5	-1.2	-0.9
Lifetime Intake	2.7	3.3	4.4	2.1	2.0	2.0	2.1	-1.3	-1.3
Liver weight, left	2.2	3.8	6.5	1.7	1.7	1.6	1.6	-2.6	-2.3
Liver weight, right	2.0	3.5	4.8	1.8	1.8	1.8	1.6	-2.2	-2.0
Locomotor activity	0.9	1.4	2.0	-1.4	-1.3	-1.2	-1.4	0.7	1.0
Locomotor testing distance	0.4	0.9	1.4	-1.2	-1.1	-1.0	-1.2	0.3	0.6
Locomotor testing rearing	0.4	1.5	2.0	-1.4	-1.3	-1.2	-1.3	1.1	1.1
Locomotion in novel chamber	0.1	0.1	0.3	-0.4	-0.5	-0.3	-0.5	0.1	0.4
Locomotion in novel chamber post-restriction	0.4	1.1	1.5	-1.2	-1.1	-1.2	-1.2	0.7	0.6
Fecal boli incidents, locomotor time 1	0.0	0.1	0.4	0.0	0.0	-0.0	0.1	-0.4	-0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.2	0.3	0.1	-0.0	-0.5	-0.3
Time >=10cm from walls, locomotor time 1	1.7	2.2	2.9	1.4	1.5	1.5	1.4	-1.7	-1.3
Bouts of movement, locomotor time 1	0.4	0.5	0.7	-0.6	-0.8	-0.7	-0.5	0.8	0.7
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.3	-0.5	-0.4	-0.3	0.2	0.1
Rest time, locomotor task time 1	0.0	0.1	0.1	-0.2	-0.3	-0.3	-0.2	0.2	0.3
Distance moved, locomotor task time 1	0.1	0.4	0.8	-0.5	-0.3	-0.5	-0.7	0.6	0.9
Vertical activity count, locomotor time 1	0.1	0.6	1.1	-0.8	-0.7	-0.7	-0.7	1.1	0.7
Time >=10cm from walls, locomotor time 2	1.6	4.6	6.7	2.0	2.1	2.0	1.9	-2.6	-2.2
Bouts of movement, locomotor time 2	0.0	0.1	0.2	0.4	0.2	0.3	0.4	0.0	-0.4
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.1	-0.1	0.1	0.2	0.3	-0.4
Rest time, locomotor task time 2	0.7	1.1	1.7	-1.0	-1.2	-1.1	-0.9	1.3	0.7
Distance moved, locomotor task time 2	0.4	0.6	1.9	-0.5	-0.3	-0.5	-0.6	0.7	1.4
Vertical activity count, locomotor time 2	0.0	0.1	0.3	0.3	0.5	0.4	0.3	0.2	0.1
Light reinforcement 1	0.3	1.5	2.5	1.5	1.4	1.4	1.6	-0.2	-0.4
Light reinforcement 2	1.0	2.2	3.4	1.7	1.6	1.6	1.8	-1.1	-0.8
Bone: marrow area	3.5	8.5	9.7	3.1	3.0	3.1	3.0	-2.6	-2.6
Bone: maximum diameter	4.3	8.6	10.0	2.9	2.9	2.9	2.8	-3.2	-3.0
Bone: maximum force	2.9	5.7	6.4	2.5	2.5	2.5	2.4	-2.1	-2.3
Bone: maximum moment	4.0	7.6	8.2	2.9	2.8	2.8	2.7	-2.5	-2.8
Mean time between licks in bursts	0.1	0.4	0.9	0.6	0.6	0.6	0.7	-1.0	-0.1
Mean num. licks in bursts	0.3	0.7	1.1	0.9	0.9	0.8	0.8	-0.6	-1.0
Cd content in liver	2.4	2.7	2.9	1.7	1.7	1.7	1.7	-1.5	-1.5
Co content in liver	0.2	0.2	0.4	0.4	0.4	0.4	0.3	-0.6	-0.6
Cu content in liver	0.1	0.2	0.2	-0.4	-0.5	-0.4	-0.4	-0.1	0.4
Fe content in liver	0.3	0.3	0.8	-0.3	-0.3	-0.3	-0.3	-0.8	-0.9
K content in liver	0.6	0.6	1.0	-1.0	-0.9	-0.8	-1.0	0.6	0.3
Mg content in liver	0.1	0.1	0.1	-0.3	-0.2	-0.2	-0.4	0.2	-0.1
Mn content in liver	0.2	0.3	0.6	0.3	0.3	0.4	0.4	-0.8	-0.7
Na content in liver	2.2	2.5	3.4	-1.8	-1.7	-1.7	-1.8	1.3	1.0
Rb content in liver	1.1	1.3	3.1	-1.1	-0.9	-1.0	-1.2	1.8	0.2
Se content in liver	2.2	2.6	3.6	-1.9	-1.8	-1.8	-1.8	0.6	1.3
Sr content in liver	3.1	2.7	3.4	-1.7	-1.7	-1.7	-1.6	1.3	1.8
Zn content in liver	0.1	0.1	0.3	0.1	0.1	0.2	0.2	-0.5	0.3
Bone: minimum diameter	1.9	3.6	4.1	2.0	2.0	2.0	1.9	-1.7	-1.8
Time in familiar zone, hab. session 1	1.0	1.1	1.2	1.0	1.0	1.0	1.0	-1.0	-1.1
Time in novel zone, hab. session 1	4.1	4.6	7.7	-1.9	-1.9	-1.9	-1.9	2.8	2.3
Total zone transitions, hab. session 1	5.5	7.7	9.7	-3.1	-3.1	-3.1	-3.1	1.8	2.1
Total locomotion distance, hab. session 1	3.2	4.6	6.6	-2.5	-2.6	-2.5	-2.5	0.6	1.3
Locomotion velocity, hab. session 1	1.6	2.3	3.6	-1.8	-1.9	-1.8	-1.8	-0.2	0.5
Time in familiar zone, hab. session 2	0.2	0.2	0.3	0.5	0.5	0.5	0.6	0.0	-0.2
Time in novel zone, hab. session 2	0.5	0.5	0.7	-0.8	-0.8	-0.8	-0.8	0.7	0.6
Total zone transitions, hab. session 2	4.7	6.1	6.4	-2.5	-2.5	-2.5	-2.5	2.3	2.5
Total locomotion distance, hab. session 2	1.1	1.4	2.1	-1.4	-1.5	-1.4	-1.4	0.1	0.9
Locomotion velocity, hab. session 2	0.7	0.9	1.4	-1.1	-1.2	-1.1	-1.1	-0.3	0.6
Novel to familiar place preference ratio	0.4	0.5	2.1	-0.3	-0.4	-0.3	-0.3	-1.4	-0.5
Novelty place preference	0.4	0.6	1.3	-0.7	-0.7	-0.6	-0.7	-1.1	-0.3
Time in novel zone, NPP test	0.5	0.6	0.9	-0.8	-0.9	-0.8	-0.8	-1.0	-0.1
Total zone transitions, NPP test	3.7	5.5	6.8	-2.3	-2.3	-2.3	-2.2	2.3	2.6
Total locomotion distance, NPP test	1.3	1.8	2.3	-1.4	-1.4	-1.4	-1.3	0.7	1.5
Locomotion velocity, NPP test	0.8	1.1	1.5	-1.1	-1.2	-1.1	-1.1	0.4	1.2
Intraocular pressure	0.3	0.6	1.1	0.8	0.6	0.5	0.7	-0.7	-1.1
Delta distance traveled before/after self-admin	0.6	0.7	0.9	0.9	1.0	0.9	0.7	-1.0	-0.5
Delta ambulatory time before/after self-admin	0.2	0.3	0.5	0.5	0.6	0.6	0.4	-0.7	-0.4
Parametrial fat weight	0.3	0.6	1.4	-0.5	-0.5	-0.5	-0.4	1.2	1.2
Pavlov. Cond. lever latency	0.4	0.6	1.5	-0.6	-0.6	-0.6	-0.7	1.2	0.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	-0.4	-0.6	-0.5	-0.4	-0.5	-0.4
Pavlov. Cond. change in total contacts	0.4	0.4	0.6	-0.7	-0.7	-0.7	-0.7	0.1	0.5
Pavlov. Cond. index score	0.1	0.1	0.5	-0.2	-0.3	-0.2	-0.1	-0.7	-0.3
Pavlov. Cond. latency score	0.2	0.2	0.9	0.0	-0.1	-0.0	0.1	-1.0	-0.5
Pavlov. Cond. lever contacts	0.3	0.4	1.3	0.4	0.3	0.4	0.4	-1.2	-0.6
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	0.4	0.6	0.5	0.4	0.5	0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.2	-0.5	-0.3	-0.4	-0.4	1.1	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	-0.2	-0.3	-0.2	-0.1	-0.7	-0.2
Pavlov. Cond. response bias	0.1	0.1	0.5	-0.2	-0.3	-0.2	-0.2	-0.7	-0.3
Pavlov. Cond. lever latency	0.6	0.9	1.1	-1.0	-0.9	-1.0	-1.0	1.0	0.6
Pavlov. Cond. magazine entry latency	0.3	0.4	0.6	-0.7	-0.7	-0.7	-0.7	0.1	0.7
Pavlov. Cond. change in total contacts	0.2	0.5	0.7	0.7	0.7	0.7	0.7	-0.9	-0.1
Pavlov. Cond. index score	0.1	0.2	0.5	0.3	0.3	0.4	0.4	-0.7	0.0
Pavlov. Cond. latency score	0.5	0.8	1.8	0.8	0.7	0.8	0.9	-1.3	-0.5
Pavlov. Cond. lever contacts	0.5	0.8	0.9	0.9	0.9	0.9	1.0	-0.9	-0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.2	0.2	0.2	0.2	-0.0	-0.6
Pavlov. Cond. intertrial magazine entries	0.3	0.6	1.9	0.6	0.7	0.6	0.5	0.0	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.5	0.4	0.3	0.4	0.4	-0.7	0.0
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	0.1	0.2	0.2	-0.1	0.3
Time in closed arm before self-admin	0.1	0.2	0.3	0.5	0.6	0.6	0.5	-0.3	-0.1
Time in closed arm after self-admin	0.2	0.2	0.3	-0.4	-0.3	-0.4	-0.6	0.3	0.5
Time in open arm before self-admin	0.4	0.5	2.7	0.0	0.1	0.2	-0.1	-1.7	-0.4
Time in open arm after self-admin	0.3	0.3	0.6	0.6	0.5	0.6	0.7	-0.3	-0.7
Bone: periosteal estimation	5.3	12.6	13.7	3.7	3.6	3.6	3.6	-3.5	-3.2
Bone: periosteal perimeter	5.2	10.3	10.7	3.2	3.2	3.2	3.1	-3.2	-3.3
Bone: post-yield work	1.3	2.3	3.3	1.6	1.7	1.6	1.4	-0.7	-1.8
Progressive ratio test 1 active lever presses	1.5	2.6	3.3	1.8	1.6	1.5	1.8	-1.0	-1.7
Progressive ratio test 1 breakpoint	1.4	2.3	3.1	1.7	1.6	1.5	1.8	-0.9	-1.6
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.2	0.1	0.1	0.1	0.1	-0.1	-0.4
Progressive ratio test 2 active lever presses	0.5	0.7	1.0	1.0	1.0	0.8	1.0	-0.3	-0.7
Progressive ratio test 2 breakpoint	0.6	0.7	1.1	1.0	1.0	0.9	1.0	-0.4	-0.8
Progressive ratio test 2 inactive lever presses	0.1	0.4	0.8	0.5	0.6	0.5	0.4	-0.9	-0.7
Incentive Sensitization - Responses	0.1	0.2	0.3	-0.3	-0.3	-0.4	-0.4	0.5	0.3
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.1	-0.0	-0.2	-0.1	0.3	0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.3	0.2	0.2	0.3	0.2	-0.5
Progressive ratio	0.1	0.4	0.6	-0.7	-0.6	-0.7	-0.8	0.3	0.4
Food seeking constrained by brief footshock	17.2	21.5	24.6	5.0	4.9	4.9	5.0	-3.7	-4.2
Seeking ratio, punishment vs. effort	3.5	7.9	10.0	3.1	3.0	3.0	3.2	-2.0	-2.3
Retroperitoneal fat weight	1.0	4.3	8.4	-1.8	-1.8	-1.7	-1.7	2.9	2.2
Reaction time number correct	0.1	0.2	0.5	0.3	0.4	0.4	0.2	-0.7	-0.6
Reaction time mean minus median	0.1	0.8	1.0	-0.9	-0.7	-0.9	-0.9	0.9	1.0
Reaction time mean minus median AUC	0.1	0.6	0.9	-0.7	-0.6	-0.7	-0.7	0.9	0.9
Reaction time num false alarms	0.2	0.3	0.8	-0.3	-0.4	-0.3	-0.4	0.7	0.9
Reaction time num false alarms AUC	0.0	0.1	0.3	-0.1	-0.2	-0.1	-0.1	0.4	0.6
Reaction time trials correct on left	0.1	0.2	0.5	0.3	0.4	0.4	0.2	-0.7	-0.6
Reaction time trials on left	0.1	0.3	0.7	0.4	0.5	0.5	0.2	-0.9	-0.7
Reaction time mean	0.0	0.0	0.1	0.2	0.3	0.2	0.2	0.1	-0.1
Reaction time mean AUC	0.0	0.1	0.2	0.3	0.4	0.4	0.3	-0.1	-0.3
Median of all reaction times	0.2	0.3	0.4	0.6	0.6	0.6	0.5	-0.3	-0.4
Reaction time omissions	0.4	0.7	1.6	0.7	0.7	0.7	0.6	-1.2	-0.9
Reaction time false alarm rate	0.3	0.5	0.8	-0.5	-0.7	-0.6	-0.5	0.9	0.8
Reaction time premature initiation rate	0.2	0.2	0.4	-0.5	-0.6	-0.7	-0.4	0.5	0.2
Reaction time premature initiations	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.1	-0.0	-0.3
Std. dev. reaction times	0.2	0.8	1.3	-0.8	-0.6	-0.8	-0.9	1.0	1.1
Reaction time trials completed	0.1	0.3	0.7	0.4	0.5	0.5	0.2	-0.9	-0.7
Reaction time trials AUC	0.1	0.3	0.7	0.4	0.6	0.5	0.3	-0.8	-0.7
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.6	-0.7	-0.6	-0.6	0.2	0.5
Run reversals in cocaine runway, males	0.1	0.1	0.3	-0.1	-0.0	-0.1	-0.1	0.5	-0.4
Latency to leave start box in cocaine runway	0.3	0.4	1.6	0.5	0.3	0.2	0.5	-0.4	-1.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.4	0.0	-0.1	-0.2	0.0	0.1	-0.6
Latency to leave start box in cocaine runway, M	0.4	0.3	1.1	0.5	0.4	0.4	0.5	-0.4	-1.0
Std. dev. time between licks in bursts	0.5	0.9	1.5	1.0	0.9	1.0	1.0	-1.2	-0.6
Total sessions with >9 infusions	0.3	0.3	0.5	0.7	0.6	0.5	0.7	-0.5	-0.4
Short access day 1 total inactive lever presses	0.1	0.1	0.2	0.4	0.4	0.4	0.4	0.3	0.0
Short access day 10 total inactive lever presses	0.3	2.4	4.0	-1.4	-1.3	-1.2	-1.5	1.7	2.0
Short access day 1 total infusions	0.1	0.1	0.2	-0.2	-0.2	-0.3	-0.2	0.5	0.5
Short access day 10 total infusions	0.5	0.8	1.1	0.9	0.9	0.9	1.0	-0.8	-0.8
Short access total infusions	0.8	1.1	1.5	1.2	1.1	1.1	1.2	-0.9	-0.8
Short access day 1 locomotion	0.3	0.5	0.7	-0.8	-0.8	-0.8	-0.8	0.2	0.4
Short access day 10 total locomotion	0.1	0.4	0.6	-0.7	-0.7	-0.8	-0.6	-0.4	-0.2
Short access total locomotion	0.1	0.2	0.6	0.1	-0.1	-0.1	0.1	-0.8	-0.5
One hour access (0.3 mA shock)	0.9	1.1	1.6	1.2	1.3	1.2	1.2	-0.3	-0.6
Compulsive drug intake	0.2	0.2	0.8	-0.3	-0.2	-0.3	-0.4	0.9	0.5
One hour access (shock baseline)	0.5	1.2	1.4	1.2	1.1	1.1	1.2	-1.0	-0.8
Social response proportion	2.3	3.0	4.7	-1.6	-1.5	-1.5	-1.5	1.9	2.2
Social responses	0.6	0.8	2.4	-0.6	-0.5	-0.5	-0.5	1.0	1.6
Social time	0.6	0.9	2.4	-0.7	-0.8	-0.9	-0.6	1.6	0.7
Soleus weight	2.6	7.8	10.1	2.7	2.7	2.6	2.6	-3.2	-3.0
Bone: stiffness	0.4	0.7	0.9	1.0	0.9	1.0	0.9	-0.7	-0.8
Tibialis anterior weight	7.4	25.3	31.0	5.6	5.5	5.5	5.5	-4.1	-3.7
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.4	-0.5	-0.3	-0.3	0.0	-0.2
Time to tail flick, vehicle, after self-admin	0.6	1.3	3.2	0.9	0.9	0.9	0.9	-1.8	-1.1
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.1	0.0	0.2	0.1	-0.1	0.3
Time to tail flick, test, after self-admin	0.2	0.2	1.3	-0.0	0.2	0.2	0.0	-1.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.3	0.7	0.8	0.6	0.6	-1.2	-0.7
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.5	-0.3	-0.4	-0.6	-0.7	0.1
Tibia length	2.2	6.0	7.1	2.6	2.7	2.5	2.4	-1.9	-2.6
Ambulatory time before self-admin	0.4	1.3	1.6	-1.2	-1.1	-1.1	-1.2	1.1	1.1
Ambulatory time after self-admin	0.0	0.0	0.1	0.2	0.3	0.3	0.1	-0.0	0.1
Bone: tissue strength	1.4	1.4	2.1	-1.2	-1.1	-1.2	-1.2	1.4	1.0
Total heroin consumption	0.3	0.3	0.7	-0.3	-0.7	-0.8	-0.3	0.7	-0.4
Bone: trabecular number	0.3	0.5	0.8	0.6	0.6	0.6	0.5	-0.9	-0.8
Bone: trabecular spacing	0.2	0.3	0.4	0.6	0.6	0.6	0.7	0.2	0.5
Bone: trabecular thickness	0.1	0.1	0.4	-0.2	-0.2	-0.2	-0.4	-0.4	-0.6
Bone: trabecular tissue density	3.5	6.1	9.8	-2.2	-2.0	-2.0	-2.1	3.1	3.1
Water consumed over 24 hours	1.3	2.4	5.2	1.4	1.3	1.3	1.4	-2.3	-1.4
Number of responses in last shaping day	1.6	2.0	2.4	1.4	1.4	1.3	1.5	-1.3	-1.6