Hub : Genes

LOC134486367

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC134486367	0.12	0.05	0.0e+00	0.14	0.13	0.13	0.14	5.4e-20	1.8e-19	2.1e-19	2.5e-20
2	NAcc	isoform ratio	XR_010065198.1	0.07	0.04	3.6e-08	0.06	0.06	0.06	0.06	2.2e-09	6.1e-10	2.0e-09	9.8e-10
3	BLA	alternative TSS	XR_010065199.1	0.09	0.05	8.1e-04	0.03	0.05	0.04	0.03	1.2e-02	1.0e-03	2.5e-03	7.2e-03
4	NAcc	alternative TSS	XR_010065199.1	0.08	0.04	1.4e-08	0.06	0.06	0.07	0.05	5.2e-09	4.0e-09	3.5e-11	1.5e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.6	1.1	1.6	1.3	1.3	-0.6	-0.9
Area under the delay curve	0.3	0.4	0.8	0.7	0.4	-0.9	-0.3
BMI with tail	0.4	1.4	5.0	0.4	0.4	0.6	-2.2
BMI without tail	0.0	0.1	0.2	-0.3	-0.4	0.2	-0.0
Body weight	0.3	1.5	3.6	-0.4	0.2	1.9	-1.5
Weight adjusted by age	0.4	0.6	1.1	1.0	0.9	-0.7	-0.3
Bone surface	0.0	0.1	0.1	0.3	0.4	-0.1	-0.3
Bone volume	0.1	0.2	0.4	0.5	0.6	0.2	-0.5
Breakpoint value in progressive ratio session	3.5	4.2	5.6	2.4	2.2	-2.2	-1.2
Number of licking bursts	0.1	0.2	0.9	0.1	0.3	-0.0	0.9
Context. condit. distance diff. score	0.4	0.4	1.1	0.5	1.1	0.5	0.3
Locomotion velocity, session 1	0.5	0.5	1.8	0.5	0.0	-0.2	-1.3
Locomotion distance, session 1	0.1	0.1	0.3	0.5	0.3	-0.2	-0.1
Locomotion velocity, session 2	0.3	0.3	1.0	0.3	-0.2	-1.0	-0.1
Locomotion distance, session 2	0.5	0.7	1.2	-1.0	-1.1	0.6	0.4
Locomotion velocity, session 3	0.5	0.6	1.2	1.1	0.8	-0.6	-0.5
Locomotion distance, session 3	0.2	0.3	0.6	0.4	0.3	-0.8	0.4
Stereotopy head waving bouts, day 3	1.3	1.5	2.7	-1.5	-0.7	1.7	0.7
Stereotopy head waving duration, day 3	1.0	1.1	2.6	-1.2	-0.5	1.6	0.5
Locomotion velocity, session 7	0.5	0.6	1.2	-0.6	-1.1	-0.2	0.8
Locomotion distance, session 7	0.3	0.4	0.7	-0.7	-0.8	0.4	0.6
Stereotopy head waving bouts, day 7	0.4	0.4	0.8	0.4	0.8	-0.4	0.9
Stereotopy head waving duration, day 7	0.3	0.4	1.1	0.2	0.6	-0.4	1.0
Locomotion velocity, session 8	0.1	0.1	0.4	0.0	-0.2	0.0	0.6
Locomotion distance, session 8	0.2	0.3	0.7	0.4	0.8	0.6	0.2
Degree of sensitization distance	0.3	0.3	0.8	-0.3	0.1	0.9	0.5
Degree of sensitization stereotypy	1.5	1.7	2.8	1.6	1.7	-1.2	-0.1
Conditioned locomotion	0.3	0.3	1.0	0.0	0.4	-0.3	1.0
Cocaine response after cond. corrected	1.2	1.4	2.9	1.4	1.7	-0.5	-0.8
Cocaine response after cond. not corrected	0.2	0.2	0.3	0.0	0.6	0.5	0.4
Cocaine response before conditioning	3.5	4.2	5.4	-2.3	-1.9	1.8	2.1
Saline control response	1.2	1.6	3.8	1.0	1.0	0.8	-2.0
Bone: connectivity density	1.1	1.7	2.6	1.4	1.6	-0.8	-1.1
Bone: cortical apparent density	0.5	0.7	1.9	0.7	0.7	-0.2	-1.4
Bone: cortical area	2.9	4.4	8.2	-2.3	-2.0	2.9	0.4
Bone: cortical porosity	0.4	0.4	1.4	-0.5	-0.1	0.1	1.2
Bone: cortical porosity	0.6	0.6	0.9	-0.9	-0.6	0.7	0.8
Bone: cortical thickness	1.2	1.9	4.8	-1.2	-0.9	2.2	-0.7
Bone: cortical thickness	1.6	1.8	4.2	-1.4	-0.9	2.0	0.6
Bone: cortical tissue density	0.6	0.8	1.9	0.8	0.8	-0.3	-1.4
Condit. Reinf. active minus inactive responses	0.7	0.8	1.6	-1.3	-0.8	0.8	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.7	-0.5	0.5	0.2
Condit. Reinf. active responses	1.8	2.2	3.9	-2.0	-1.6	1.0	1.2
Condit. Reinf. inactive responses	1.8	2.2	3.5	-1.9	-1.7	0.7	1.4
Incentive salience index mean	0.7	0.8	1.7	-1.3	-0.9	0.7	0.4
Condit. Reinf. lever presses	0.2	0.3	0.4	-0.6	-0.3	0.7	-0.4
Condit. Reinf. active minus inactive responses	2.6	3.4	7.0	-2.0	-1.7	2.6	-0.0
Condit. Reinf. active-inactive response ratio	1.3	1.6	2.7	-1.3	-1.4	1.6	0.2
Condit. Reinf. active responses	2.9	4.0	8.5	-2.2	-1.7	2.9	-0.2
Condit. Reinf. inactive responses	0.7	0.9	2.6	-1.0	-0.3	1.6	-0.2
Condit. Reinf. lever presses	3.9	5.5	10.0	-2.7	-2.0	3.2	0.7
Condit. Reinf. lever reinforcers received	2.5	3.5	7.4	-1.9	-1.6	2.7	-0.4
Conditioned reinforcement - actives	0.6	1.1	1.4	-1.1	-1.2	1.0	0.7
Conditioned reinforcement - inactives	0.2	0.3	0.7	-0.4	-0.6	-0.2	0.8
Conditioned locomotion	0.4	0.5	1.3	-0.4	-0.6	1.1	-0.2
Patch foraging indifference point 0 sec	0.6	1.0	2.3	1.3	1.5	-0.0	-0.4
Patch foraging indifference point AUC	1.9	2.7	4.9	-1.5	-1.9	-0.5	2.2
Delay disc. indifference point, 0s delay	0.4	0.4	1.4	-0.3	-0.3	0.4	-1.2
Delay disc. indifference point, 16s delay	0.4	0.5	1.2	0.3	0.2	-1.1	0.8
Delay disc. indifference point, 2s delay	0.6	0.6	1.3	-0.2	-0.9	-0.7	-1.1
Delay disc. indifference point, 24s delay	0.9	1.0	1.8	0.8	0.7	-1.3	1.1
Delay disc. indifference point, 4s delay	1.7	1.7	4.3	1.2	0.7	-0.8	-2.1
Delay disc. indifference point, 8s delay	0.2	0.3	0.5	0.7	0.4	-0.7	0.1
Indifference point function ln k	0.1	0.2	0.6	0.1	0.3	0.4	-0.8
Indifference point function log k	0.1	0.2	0.6	0.1	0.3	0.4	-0.8
Patch foraging total patch changes 0 sec	1.0	1.8	3.6	1.8	1.9	-0.3	-0.7
Patch foraging total patch changes 12 sec	0.6	0.7	1.4	-0.7	-0.9	0.4	1.2
Patch foraging total patch changes 18 sec	1.4	2.1	5.8	-1.1	-1.1	-0.2	2.4
Patch foraging total patch changes 24 sec	0.7	1.1	2.2	-1.1	-0.8	1.5	0.8
Patch foraging total patch changes 6 sec	0.4	0.6	0.9	0.7	0.6	-0.9	1.0
Patch foraging time to switch 0 sec	0.5	0.9	1.8	1.0	1.4	-0.1	-1.0
Patch foraging water rate 0 sec	0.7	1.4	2.0	-1.4	-1.3	1.1	1.0
Patch foraging water rate 12 sec	1.1	2.2	3.8	-1.7	-2.0	1.4	-0.1
Patch foraging water rate 18 sec	1.1	1.6	2.8	-0.8	-1.1	1.7	-1.4
Patch foraging water rate 24 sec	0.1	0.1	0.3	-0.1	-0.4	0.5	-0.1
Patch foraging water rate 6 sec	1.2	1.8	2.5	-1.6	-1.6	1.5	0.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.5	-0.7	-0.5	0.6	0.2
Distance traveled before self-admin	0.8	1.1	3.1	-0.9	-0.5	1.8	-0.5
Distance traveled after self-admin	2.0	2.5	3.6	-1.9	-1.9	1.5	0.6
Extensor digitorum longus weight	0.5	2.1	3.7	-1.6	-1.9	1.5	-0.2
Bone: elastic displacement	0.4	0.5	1.6	0.4	0.2	0.3	-1.2
Bone: elastic work	1.5	1.9	5.6	0.0	-0.1	1.5	-2.4
Bone: endosteal estimation	1.2	2.7	4.0	-1.7	-1.7	0.9	2.0
Bone: endosteal perimeter	2.3	4.8	6.9	-2.6	-2.6	1.7	1.7
Epididymis fat weight	6.4	21.9	34.9	5.9	5.3	-4.2	-2.6
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	0.6	0.4	-0.1	-0.7
Delta time in open arm before/after self-admin	0.5	0.5	1.3	-0.7	-0.3	1.1	-0.2
Diff in mean of infusions in LGA sessions	9.8	11.9	16.1	4.0	3.9	-3.4	-2.2
Delay discount exponential model param	0.4	0.5	1.0	-0.8	-0.4	1.0	0.2
Extinction: sum of active levers before priming	0.3	0.4	1.2	0.3	0.3	0.3	-1.1
Active lever presses in extinction session 6	0.9	0.8	3.1	0.4	0.3	0.1	-1.8
Bone: final force	3.7	5.8	9.1	-2.9	-3.0	1.9	1.6
Bone: final moment	3.9	6.3	10.1	-3.0	-3.2	2.1	1.5
Food consumed during 24 hour testing period	0.6	0.9	1.9	-1.0	-0.7	1.4	0.1
Glucose	0.9	1.3	3.2	-1.3	-1.8	0.8	0.1
Heart weight	0.1	0.1	0.2	-0.4	-0.1	-0.3	0.4
Delay discount hyperbolic model param	0.5	0.5	1.2	-0.8	-0.4	1.1	0.5
Intermittent access intake day 1-15 change	0.9	1.8	4.3	-1.5	-2.1	0.8	-0.2
Intermittent access intake escalation	0.6	1.2	3.0	-1.2	-1.7	0.4	-0.1
Intermittent access intake escalation 2	1.0	1.1	2.6	-1.2	-1.6	0.7	-0.3
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	-0.1	0.4	-0.2	-0.3
Intermitt. access day 15 inactive lever presses	0.2	0.5	0.6	-0.7	-0.6	0.8	0.6
Intermitt. access escalation Index	0.1	0.1	0.5	0.2	0.7	0.0	-0.1
Intermittent access day 1 total infusions	0.2	0.3	1.1	0.1	0.2	-0.3	1.0
Intermittent access day 15 total infusions	0.5	0.7	1.2	-0.8	-1.1	-0.2	1.0
Intermittent access terminal intake (last 3 days)	0.4	0.6	1.1	-0.8	-1.0	0.4	0.6
Intermittent access total infusions	0.3	0.3	1.0	-0.3	-0.4	-0.0	1.0
Intermittent access day 1 locomotion	0.6	0.7	1.9	1.0	1.4	0.0	0.2
Intermittent access day 15 total locomotion	0.3	0.5	0.8	-0.5	-0.8	0.9	-0.6
Intermittent access total locomotion	0.1	0.2	0.6	-0.0	-0.1	0.8	-0.2
Intermittent access standard deviation	1.3	2.8	5.8	-2.0	-2.4	1.1	0.4
Left kidney weight	0.6	2.6	4.7	-1.9	-2.2	1.4	0.2
Right kidney weight	1.2	5.5	8.6	-2.7	-2.9	2.4	-0.1
Cocaine induced anxiety	1.9	2.7	3.8	2.0	1.8	-0.6	-1.8
Post-drug Anxiety	0.1	0.1	0.2	0.0	0.2	0.4	0.5
Baseline Anxiety	2.9	3.3	5.6	-2.1	-1.4	1.1	2.4
Tail length	1.0	3.8	7.8	-2.0	-1.6	1.0	2.8
Length with tail	0.4	1.6	2.6	-1.4	-0.7	1.6	1.2
Length without tail	0.5	1.5	4.0	-1.0	-0.4	2.0	-1.0
Times rat made contact with spout	0.2	0.2	0.3	0.6	0.4	0.2	-0.5
Lifetime Intake	0.1	0.2	0.5	-0.3	-0.3	-0.1	0.7
Liver weight, left	0.2	0.3	1.2	-0.1	-0.0	1.1	-0.3
Liver weight, right	0.6	1.1	1.8	-1.1	-1.0	1.3	-0.5
Locomotor activity	1.3	2.1	2.9	-1.7	-1.6	1.7	-0.0
Locomotor testing distance	2.2	3.9	5.4	-2.3	-2.2	2.3	-0.1
Locomotor testing rearing	4.3	8.7	11.6	-3.4	-3.4	3.4	0.3
Locomotion in novel chamber	0.0	0.1	0.1	0.1	0.3	-0.2	0.3
Locomotion in novel chamber post-restriction	0.9	1.4	2.4	0.3	1.2	1.3	-1.5
Fecal boli incidents, locomotor time 1	1.3	1.9	4.7	0.3	1.0	-1.3	2.2
Change in fecal boli incidents, locomotor task	0.4	0.4	0.7	-0.7	-0.8	0.8	-0.1
Time >=10cm from walls, locomotor time 1	0.4	0.5	0.8	-0.9	-0.4	0.7	0.7
Bouts of movement, locomotor time 1	5.8	6.6	13.2	3.1	3.6	-1.8	-0.4
Total resting periods, locomotor time 1	6.0	6.7	12.8	3.2	3.6	-1.9	-0.5
Rest time, locomotor task time 1	2.9	3.7	7.4	2.0	2.7	-1.5	1.1
Distance moved, locomotor task time 1	2.8	4.2	5.9	-1.8	-2.4	2.0	-1.9
Vertical activity count, locomotor time 1	0.7	1.7	3.1	-0.7	-1.4	1.0	-1.8
Time >=10cm from walls, locomotor time 2	1.7	2.5	4.1	-2.0	-1.7	1.6	0.6
Bouts of movement, locomotor time 2	1.1	1.8	4.0	1.5	2.0	-1.0	0.1
Total resting periods, locomotor time 2	1.9	3.3	6.7	2.1	2.6	-1.5	-0.0
Rest time, locomotor task time 2	1.6	2.1	4.9	1.5	2.2	-0.7	0.9
Distance moved, locomotor task time 2	3.7	4.4	6.6	-1.7	-2.0	2.6	-2.1
Vertical activity count, locomotor time 2	0.8	1.0	3.0	-0.3	-0.9	0.4	-1.7
Light reinforcement 1	0.1	0.4	1.1	-0.1	-0.1	0.6	-1.0
Light reinforcement 2	0.2	0.3	0.5	0.7	0.6	-0.2	-0.6
Bone: marrow area	1.1	2.4	3.8	-1.6	-1.7	0.8	1.9
Bone: maximum diameter	1.7	3.2	5.2	-2.0	-1.6	2.3	1.1
Bone: maximum force	3.1	5.4	7.7	-2.7	-2.8	2.4	0.9
Bone: maximum moment	3.5	6.1	9.1	-2.8	-3.0	2.6	0.8
Mean time between licks in bursts	1.0	2.4	4.1	-1.7	-1.6	2.0	-0.4
Mean num. licks in bursts	0.3	0.5	2.1	0.2	-0.0	0.2	-1.4
Cd content in liver	0.3	0.4	0.8	0.3	0.3	-0.9	0.7
Co content in liver	1.1	1.3	2.1	-1.5	-1.0	1.3	0.5
Cu content in liver	0.7	0.8	1.4	-0.4	-0.8	-1.1	1.2
Fe content in liver	1.5	1.8	2.3	1.4	1.2	-1.5	-1.3
K content in liver	0.4	0.3	0.6	-0.5	-0.8	0.2	0.6
Mg content in liver	0.5	0.5	0.8	-0.6	-0.9	0.2	0.9
Mn content in liver	1.2	1.4	2.3	-1.5	-1.5	0.9	0.3
Na content in liver	0.9	1.0	2.1	-1.0	-0.9	1.4	-0.3
Rb content in liver	1.8	2.1	3.0	-1.7	-1.5	0.6	1.7
Se content in liver	0.2	0.2	0.6	0.4	0.8	-0.4	0.2
Sr content in liver	0.6	0.5	0.9	-0.9	-0.8	0.8	-0.2
Zn content in liver	0.2	0.2	0.4	0.2	0.6	0.6	0.5
Bone: minimum diameter	0.8	1.4	2.6	-1.3	-1.2	1.6	0.1
Time in familiar zone, hab. session 1	2.0	1.9	5.4	-1.1	-1.0	-0.3	2.3
Time in novel zone, hab. session 1	2.5	2.5	7.8	1.2	0.9	-0.0	-2.8
Total zone transitions, hab. session 1	1.5	2.0	6.1	-1.1	-0.7	2.5	-0.6
Total locomotion distance, hab. session 1	1.9	2.7	5.0	-1.7	-1.7	2.2	-0.4
Locomotion velocity, hab. session 1	1.2	1.7	3.6	-1.3	-1.3	1.9	-0.2
Time in familiar zone, hab. session 2	3.5	3.7	6.5	2.2	2.6	-0.0	-1.8
Time in novel zone, hab. session 2	2.3	2.3	3.6	-1.7	-1.9	-0.2	1.7
Total zone transitions, hab. session 2	0.4	0.5	1.6	-0.4	-0.0	1.3	-0.5
Total locomotion distance, hab. session 2	0.2	0.3	0.9	0.3	0.2	0.2	-1.0
Locomotion velocity, hab. session 2	0.2	0.3	1.2	0.2	0.0	0.2	-1.1
Novel to familiar place preference ratio	0.2	0.3	0.5	0.3	0.7	0.6	-0.2
Novelty place preference	0.3	0.4	0.8	0.6	0.9	0.3	-0.4
Time in novel zone, NPP test	0.3	0.4	0.9	0.6	0.9	0.4	-0.3
Total zone transitions, NPP test	0.1	0.2	0.5	0.0	0.6	0.7	0.0
Total locomotion distance, NPP test	0.3	0.4	0.8	-0.6	-0.5	0.9	-0.2
Locomotion velocity, NPP test	0.5	0.7	1.0	-0.9	-0.8	1.0	-0.2
Intraocular pressure	0.3	0.5	1.3	-0.6	-0.5	1.1	0.2
Delta distance traveled before/after self-admin	0.5	0.5	1.0	-0.4	-1.0	-0.7	0.4
Delta ambulatory time before/after self-admin	1.4	1.7	3.9	-1.5	-2.0	0.2	0.8
Parametrial fat weight	2.3	5.5	8.8	3.0	2.1	-1.7	-2.4
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.6	0.2	-0.8	0.2
Pavlov. Cond. magazine entry latency	0.2	0.3	0.8	-0.3	-0.1	-0.4	0.9
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	-0.6	-0.7	-0.4	0.2
Pavlov. Cond. index score	0.3	0.4	0.9	-0.9	-0.6	0.4	0.5
Pavlov. Cond. latency score	0.4	0.5	1.0	-1.0	-0.6	0.6	0.5
Pavlov. Cond. lever contacts	0.1	0.2	0.4	-0.4	0.1	0.6	-0.4
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	0.5	0.6	0.9	-0.7
Pavlov. Cond. intertrial magazine entries	1.7	2.1	2.9	-1.7	-1.4	1.4	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	-0.8	-0.4	0.3	0.3
Pavlov. Cond. response bias	0.2	0.3	0.5	-0.4	-0.4	-0.7	0.5
Pavlov. Cond. lever latency	1.7	2.3	4.2	1.7	1.3	-2.1	-0.6
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	0.3	0.8	0.0	0.9
Pavlov. Cond. change in total contacts	0.5	0.8	1.2	-1.0	-0.9	0.6	1.1
Pavlov. Cond. index score	0.3	0.4	0.8	-0.5	-0.1	0.9	0.7
Pavlov. Cond. latency score	0.1	0.2	0.4	-0.2	0.2	0.5	0.6
Pavlov. Cond. lever contacts	1.6	2.2	3.9	-1.7	-1.2	2.0	0.7
Pavlov. Cond. magazine entry number	0.8	1.0	1.8	-1.0	-1.3	0.8	-0.6
Pavlov. Cond. intertrial magazine entries	1.3	2.0	3.8	-1.5	-1.9	1.2	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	-0.4	-0.1	0.7	0.6
Pavlov. Cond. response bias	1.2	1.6	3.3	-1.3	-0.9	1.8	0.7
Time in closed arm before self-admin	0.1	0.2	0.5	-0.3	-0.0	-0.1	0.7
Time in closed arm after self-admin	0.0	0.0	0.0	-0.1	-0.1	0.0	-0.0
Time in open arm before self-admin	2.4	2.7	4.2	1.8	1.7	-2.1	-0.4
Time in open arm after self-admin	0.2	0.2	0.6	0.4	0.8	0.2	-0.1
Bone: periosteal estimation	2.2	4.7	6.0	-2.4	-2.3	2.3	1.5
Bone: periosteal perimeter	3.1	5.3	7.6	-2.7	-2.6	2.5	1.1
Bone: post-yield work	0.9	1.3	1.7	-1.2	-1.1	1.3	0.8
Progressive ratio test 1 active lever presses	0.4	0.4	0.7	-0.8	-0.6	0.7	0.6
Progressive ratio test 1 breakpoint	0.3	0.4	0.6	-0.8	-0.5	0.6	0.6
Progressive ratio test 1 inactive lever presses	0.5	0.7	1.9	-0.7	-0.3	1.4	-0.4
Progressive ratio test 2 active lever presses	0.6	0.7	2.0	-0.7	-0.5	0.0	1.4
Progressive ratio test 2 breakpoint	0.6	0.7	2.0	-0.6	-0.5	0.1	1.4
Progressive ratio test 2 inactive lever presses	1.3	2.1	5.4	-1.4	-1.1	0.2	2.3
Incentive Sensitization - Responses	0.5	0.7	2.5	-0.6	-0.4	0.1	1.6
Incentive Sensitization - Breakpoint	0.6	0.8	2.5	-0.6	-0.4	0.2	1.6
Sum of active levers in priming session hrs 5-6	1.4	1.3	3.5	1.1	0.8	-1.9	-0.0
Progressive ratio	0.1	0.2	0.4	0.3	0.7	0.5	0.1
Food seeking constrained by brief footshock	0.7	0.9	1.9	1.0	0.6	-1.4	0.5
Seeking ratio, punishment vs. effort	0.1	0.2	0.6	0.1	-0.3	-0.8	-0.3
Retroperitoneal fat weight	2.7	11.7	21.8	3.8	3.1	-1.1	-4.7
Reaction time number correct	1.1	2.2	2.6	-1.1	-1.5	1.6	-1.6
Reaction time mean minus median	0.8	2.1	2.8	1.6	1.4	-1.7	1.0
Reaction time mean minus median AUC	1.2	3.1	5.2	2.3	1.8	-2.0	0.1
Reaction time num false alarms	5.2	7.3	11.5	-3.1	-3.4	2.3	1.7
Reaction time num false alarms AUC	5.1	8.0	12.9	-3.3	-3.6	2.1	2.1
Reaction time trials correct on left	1.1	2.2	2.6	-1.1	-1.5	1.6	-1.6
Reaction time trials on left	1.1	2.1	2.4	-1.1	-1.6	1.6	-1.6
Reaction time mean	3.5	5.6	9.3	2.6	2.3	-3.0	1.1
Reaction time mean AUC	3.8	6.1	9.2	2.8	2.6	-3.0	0.9
Median of all reaction times	4.0	5.7	10.4	2.6	2.2	-3.2	0.9
Reaction time omissions	0.4	0.6	1.3	0.7	0.3	-0.9	1.1
Reaction time false alarm rate	3.2	4.4	6.3	-2.2	-2.3	1.1	2.5
Reaction time premature initiation rate	0.1	0.1	0.2	0.1	0.4	0.2	0.4
Reaction time premature initiations	0.3	0.5	1.2	-0.5	-0.5	1.1	-0.5
Std. dev. reaction times	1.4	2.5	4.0	1.5	1.2	-2.0	1.5
Reaction time trials completed	1.1	2.1	2.4	-1.1	-1.6	1.6	-1.6
Reaction time trials AUC	1.3	2.5	3.1	-1.3	-1.8	1.7	-1.6
Run reversals in cocaine runway, females	0.4	0.4	0.9	-0.1	-0.0	0.9	-0.9
Run reversals in cocaine runway, males	1.3	1.3	2.8	1.1	0.7	-0.8	-1.7
Latency to leave start box in cocaine runway	0.2	0.2	0.4	0.4	0.6	-0.0	-0.5
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.1	0.5	0.5	-0.3
Latency to leave start box in cocaine runway, M	0.8	0.8	1.2	1.1	0.9	-0.8	-0.6
Std. dev. time between licks in bursts	1.1	1.5	2.0	-1.4	-1.4	1.2	0.7
Total sessions with >9 infusions	0.1	0.1	0.2	0.3	0.5	0.3	0.3
Short access day 1 total inactive lever presses	0.1	0.1	0.4	0.0	-0.1	0.1	-0.6
Short access day 10 total inactive lever presses	0.0	0.1	0.1	-0.1	-0.2	-0.3	0.3
Short access day 1 total infusions	0.3	0.4	0.8	0.9	0.7	-0.5	-0.5
Short access day 10 total infusions	0.3	0.4	1.2	-0.6	-0.2	1.1	0.0
Short access total infusions	0.1	0.2	0.2	0.5	0.4	-0.5	-0.1
Short access day 1 locomotion	0.1	0.2	0.3	0.4	0.5	0.5	-0.2
Short access day 10 total locomotion	0.1	0.2	0.3	0.2	0.5	0.6	-0.0
Short access total locomotion	0.2	0.3	0.8	0.0	0.3	0.9	0.3
One hour access (0.3 mA shock)	2.7	3.2	4.7	-1.8	-1.6	1.5	2.2
Compulsive drug intake	0.3	0.4	1.1	0.5	0.4	-1.0	0.1
One hour access (shock baseline)	0.7	1.1	1.9	-1.0	-0.7	1.4	0.9
Social response proportion	1.6	1.8	3.5	1.4	1.0	-1.9	0.9
Social responses	2.0	2.5	3.5	-1.7	-1.9	0.6	1.8
Social time	1.0	1.4	4.1	-0.7	-0.9	-0.3	2.0
Soleus weight	0.3	0.8	1.3	-0.8	-1.1	1.1	-0.6
Bone: stiffness	4.0	6.5	9.8	-3.0	-3.1	1.9	1.9
Tibialis anterior weight	0.1	0.3	0.5	0.4	0.4	-0.7	0.6
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.8	-0.7	-0.3	0.2	1.4
Time to tail flick, vehicle, after self-admin	2.2	2.9	5.1	1.9	1.6	-2.3	-0.2
Time to tail flick, test, before self-admin	0.3	0.4	0.7	0.8	0.0	-0.3	-0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.2	-0.1	0.1	-0.5
Delta time to tail flick, vehicle, before/after SA	1.2	1.1	2.1	1.2	0.8	-1.4	-0.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.2	0.5	-0.4	0.2
Tibia length	2.5	6.9	15.4	-3.0	-1.8	3.9	0.5
Ambulatory time before self-admin	0.8	1.2	3.7	-0.9	-0.4	1.9	-0.1
Ambulatory time after self-admin	1.9	2.3	3.6	-1.7	-1.9	1.3	1.0
Bone: tissue strength	0.8	0.8	1.3	-0.9	-1.1	1.0	-0.4
Total heroin consumption	1.0	1.2	1.8	1.0	1.2	-1.3	-0.8
Bone: trabecular number	1.1	1.8	3.4	1.5	1.9	-0.7	-1.1
Bone: trabecular spacing	0.9	1.2	2.0	-1.1	-1.2	1.4	0.1
Bone: trabecular thickness	0.1	0.1	0.2	0.4	0.4	-0.3	-0.1
Bone: trabecular tissue density	0.2	0.3	0.6	-0.6	-0.8	0.4	-0.1
Water consumed over 24 hours	1.3	1.7	3.5	-1.4	-0.9	1.9	0.8
Number of responses in last shaping day	0.8	0.8	1.2	1.1	1.1	-1.0	-0.0