Hub : Genes

LOC134486366

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative TSS XR_010065195.1 0.05 0.03 7.9e-05 0.04 0.01 0.01 0.03 1.7e-05 3.0e-02 9.3e-03 7.7e-04
2 Liver alternative TSS XR_010065197.1 0.05 0.03 1.3e-04 0.04 0.01 0.01 0.02 2.9e-05 4.1e-02 1.4e-02 1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.40.70.7-0.80.8
Area under the delay curve0.00.10.10.3-0.3
BMI with tail0.10.30.3-0.60.6
BMI without tail0.31.31.3-1.21.2
Body weight1.04.34.3-2.12.1
Weight adjusted by age0.51.41.41.2-1.2
Bone surface1.22.32.3-1.51.5
Bone volume1.22.32.3-1.51.5
Breakpoint value in progressive ratio session2.34.24.22.1-2.1
Number of licking bursts0.00.00.0-0.20.2
Context. condit. distance diff. score0.10.10.1-0.40.4
Locomotion velocity, session 10.00.00.00.2-0.2
Locomotion distance, session 10.00.00.00.1-0.1
Locomotion velocity, session 21.31.61.61.2-1.2
Locomotion distance, session 20.71.01.0-1.01.0
Locomotion velocity, session 30.30.30.30.6-0.6
Locomotion distance, session 30.20.20.2-0.50.5
Stereotopy head waving bouts, day 31.41.71.7-1.31.3
Stereotopy head waving duration, day 30.40.50.5-0.70.7
Locomotion velocity, session 70.10.10.10.4-0.4
Locomotion distance, session 70.00.00.00.0-0.0
Stereotopy head waving bouts, day 70.40.40.4-0.60.6
Stereotopy head waving duration, day 70.40.50.5-0.70.7
Locomotion velocity, session 80.00.00.0-0.10.1
Locomotion distance, session 80.10.10.1-0.40.4
Degree of sensitization distance0.20.20.20.4-0.4
Degree of sensitization stereotypy0.00.00.0-0.10.1
Conditioned locomotion0.10.10.10.3-0.3
Cocaine response after cond. corrected1.92.82.81.7-1.7
Cocaine response after cond. not corrected0.40.50.50.7-0.7
Cocaine response before conditioning3.13.83.8-1.91.9
Saline control response0.10.10.10.4-0.4
Bone: connectivity density0.20.20.2-0.50.5
Bone: cortical apparent density0.10.20.2-0.40.4
Bone: cortical area5.89.49.4-3.13.1
Bone: cortical porosity3.53.93.9-2.02.0
Bone: cortical porosity5.25.75.7-2.42.4
Bone: cortical thickness4.16.86.8-2.62.6
Bone: cortical thickness6.17.47.4-2.72.7
Bone: cortical tissue density0.10.10.1-0.40.4
Condit. Reinf. active minus inactive responses7.68.68.6-2.92.9
Condit. Reinf. active-inactive response ratio2.22.42.4-1.51.5
Condit. Reinf. active responses5.57.17.1-2.72.7
Condit. Reinf. inactive responses1.62.12.1-1.41.4
Incentive salience index mean6.68.58.5-2.92.9
Condit. Reinf. lever presses0.91.31.3-1.21.2
Condit. Reinf. active minus inactive responses3.35.05.0-2.22.2
Condit. Reinf. active-inactive response ratio1.72.72.7-1.61.6
Condit. Reinf. active responses4.05.75.7-2.42.4
Condit. Reinf. inactive responses0.40.70.7-0.80.8
Condit. Reinf. lever presses5.98.68.6-2.92.9
Condit. Reinf. lever reinforcers received2.63.73.7-1.91.9
Conditioned reinforcement - actives0.93.63.6-1.91.9
Conditioned reinforcement - inactives0.00.00.0-0.10.1
Conditioned locomotion0.40.60.6-0.80.8
Patch foraging indifference point 0 sec0.10.40.4-0.60.6
Patch foraging indifference point AUC0.10.30.30.6-0.6
Delay disc. indifference point, 0s delay0.10.10.1-0.30.3
Delay disc. indifference point, 16s delay0.20.20.2-0.50.5
Delay disc. indifference point, 2s delay0.00.00.00.1-0.1
Delay disc. indifference point, 24s delay0.71.21.21.1-1.1
Delay disc. indifference point, 4s delay1.01.11.11.0-1.0
Delay disc. indifference point, 8s delay0.00.00.0-0.10.1
Indifference point function ln k0.10.40.4-0.60.6
Indifference point function log k0.10.40.4-0.60.6
Patch foraging total patch changes 0 sec0.00.10.1-0.30.3
Patch foraging total patch changes 12 sec2.23.03.0-1.71.7
Patch foraging total patch changes 18 sec1.12.52.5-1.61.6
Patch foraging total patch changes 24 sec0.82.72.7-1.71.7
Patch foraging total patch changes 6 sec0.10.20.20.4-0.4
Patch foraging time to switch 0 sec0.00.00.0-0.10.1
Patch foraging water rate 0 sec1.03.93.9-2.02.0
Patch foraging water rate 12 sec1.03.83.8-2.02.0
Patch foraging water rate 18 sec1.63.73.7-1.91.9
Patch foraging water rate 24 sec0.91.31.3-1.11.1
Patch foraging water rate 6 sec2.02.92.9-1.71.7
Seeking ratio, delayed vs. immediate footshock0.71.01.0-1.01.0
Distance traveled before self-admin1.94.14.1-2.02.0
Distance traveled after self-admin1.83.23.2-1.81.8
Extensor digitorum longus weight0.20.90.9-0.90.9
Bone: elastic displacement0.20.30.30.5-0.5
Bone: elastic work0.10.10.10.3-0.3
Bone: endosteal estimation0.41.01.0-1.01.0
Bone: endosteal perimeter0.51.11.1-1.11.1
Epididymis fat weight5.829.229.25.4-5.4
Delta time in closed arm before/after self-admin0.50.50.50.7-0.7
Delta time in open arm before/after self-admin0.60.70.7-0.90.9
Diff in mean of infusions in LGA sessions4.58.08.02.8-2.8
Delay discount exponential model param0.20.20.2-0.50.5
Extinction: sum of active levers before priming0.40.70.7-0.80.8
Active lever presses in extinction session 62.02.02.0-1.41.4
Bone: final force2.54.14.1-2.02.0
Bone: final moment2.33.73.7-1.91.9
Food consumed during 24 hour testing period1.73.33.3-1.81.8
Glucose1.01.51.5-1.21.2
Heart weight0.10.10.1-0.40.4
Delay discount hyperbolic model param0.20.30.3-0.50.5
Intermittent access intake day 1-15 change0.53.03.0-1.71.7
Intermittent access intake escalation0.52.52.5-1.61.6
Intermittent access intake escalation 20.61.01.0-1.01.0
Intermitt. access day 1 inactive lever presses0.23.03.01.7-1.7
Intermitt. access day 15 inactive lever presses0.10.40.40.6-0.6
Intermitt. access escalation Index0.00.00.0-0.00.0
Intermittent access day 1 total infusions0.00.10.1-0.20.2
Intermittent access day 15 total infusions1.02.42.4-1.61.6
Intermittent access terminal intake (last 3 days)1.62.82.8-1.71.7
Intermittent access total infusions1.41.71.7-1.31.3
Intermittent access day 1 locomotion0.40.80.80.9-0.9
Intermittent access day 15 total locomotion0.20.70.7-0.80.8
Intermittent access total locomotion0.30.30.3-0.60.6
Intermittent access standard deviation0.63.03.0-1.71.7
Left kidney weight0.43.03.0-1.71.7
Right kidney weight0.74.94.9-2.22.2
Cocaine induced anxiety0.41.01.01.0-1.0
Post-drug Anxiety0.10.10.1-0.40.4
Baseline Anxiety2.13.53.5-1.91.9
Tail length1.16.06.0-2.52.5
Length with tail1.46.06.0-2.42.4
Length without tail0.73.83.8-2.02.0
Times rat made contact with spout1.01.11.11.1-1.1
Lifetime Intake2.22.82.8-1.71.7
Liver weight, left0.61.11.1-1.01.0
Liver weight, right0.10.10.1-0.40.4
Locomotor activity2.94.54.5-2.12.1
Locomotor testing distance3.58.68.6-2.92.9
Locomotor testing rearing2.07.47.4-2.72.7
Locomotion in novel chamber0.10.10.1-0.30.3
Locomotion in novel chamber post-restriction0.41.21.2-1.11.1
Fecal boli incidents, locomotor time 10.71.91.91.4-1.4
Change in fecal boli incidents, locomotor task0.90.90.9-1.01.0
Time >=10cm from walls, locomotor time 10.30.40.4-0.60.6
Bouts of movement, locomotor time 14.45.65.62.4-2.4
Total resting periods, locomotor time 14.65.25.22.3-2.3
Rest time, locomotor task time 12.74.34.32.1-2.1
Distance moved, locomotor task time 12.16.16.1-2.52.5
Vertical activity count, locomotor time 10.21.21.2-1.11.1
Time >=10cm from walls, locomotor time 20.20.50.5-0.70.7
Bouts of movement, locomotor time 20.82.72.71.7-1.7
Total resting periods, locomotor time 20.83.43.41.8-1.8
Rest time, locomotor task time 21.22.02.01.4-1.4
Distance moved, locomotor task time 22.33.13.1-1.71.7
Vertical activity count, locomotor time 20.00.00.0-0.10.1
Light reinforcement 10.00.00.0-0.20.2
Light reinforcement 20.00.10.10.3-0.3
Bone: marrow area0.51.11.1-1.11.1
Bone: maximum diameter2.75.55.5-2.32.3
Bone: maximum force2.65.15.1-2.32.3
Bone: maximum moment2.54.84.8-2.22.2
Mean time between licks in bursts0.10.30.3-0.60.6
Mean num. licks in bursts0.20.50.50.7-0.7
Cd content in liver0.00.00.00.2-0.2
Co content in liver0.91.01.0-1.01.0
Cu content in liver0.10.10.10.3-0.3
Fe content in liver1.21.51.51.2-1.2
K content in liver0.00.00.0-0.20.2
Mg content in liver0.40.40.4-0.60.6
Mn content in liver6.87.67.6-2.82.8
Na content in liver1.82.12.1-1.41.4
Rb content in liver1.01.11.1-1.11.1
Se content in liver0.91.01.01.0-1.0
Sr content in liver0.80.70.7-0.80.8
Zn content in liver0.00.00.00.1-0.1
Bone: minimum diameter0.91.71.7-1.31.3
Time in familiar zone, hab. session 10.00.00.00.2-0.2
Time in novel zone, hab. session 10.50.50.50.7-0.7
Total zone transitions, hab. session 11.72.42.4-1.61.6
Total locomotion distance, hab. session 10.91.31.3-1.11.1
Locomotion velocity, hab. session 10.91.21.2-1.11.1
Time in familiar zone, hab. session 22.22.52.51.6-1.6
Time in novel zone, hab. session 22.32.52.5-1.61.6
Total zone transitions, hab. session 21.31.61.6-1.31.3
Total locomotion distance, hab. session 20.30.40.4-0.60.6
Locomotion velocity, hab. session 20.10.20.2-0.40.4
Novel to familiar place preference ratio0.00.00.0-0.00.0
Novelty place preference0.00.00.0-0.00.0
Time in novel zone, NPP test0.00.00.00.0-0.0
Total zone transitions, NPP test0.10.10.1-0.40.4
Total locomotion distance, NPP test0.50.70.7-0.80.8
Locomotion velocity, NPP test0.50.70.7-0.80.8
Intraocular pressure1.52.42.4-1.61.6
Delta distance traveled before/after self-admin0.50.60.60.7-0.7
Delta ambulatory time before/after self-admin0.10.10.1-0.30.3
Parametrial fat weight3.37.87.82.8-2.8
Pavlov. Cond. lever latency1.21.51.51.2-1.2
Pavlov. Cond. magazine entry latency0.20.20.2-0.40.4
Pavlov. Cond. change in total contacts1.51.61.6-1.31.3
Pavlov. Cond. index score1.11.41.4-1.21.2
Pavlov. Cond. latency score1.21.51.5-1.21.2
Pavlov. Cond. lever contacts2.02.42.4-1.51.5
Pavlov. Cond. magazine entry number0.40.50.50.7-0.7
Pavlov. Cond. intertrial magazine entries2.32.72.7-1.71.7
Pavlov. Cond. lever-magazine prob. diff.1.11.41.4-1.21.2
Pavlov. Cond. response bias0.50.60.6-0.80.8
Pavlov. Cond. lever latency5.67.97.92.8-2.8
Pavlov. Cond. magazine entry latency0.50.80.8-0.90.9
Pavlov. Cond. change in total contacts1.33.23.2-1.81.8
Pavlov. Cond. index score2.13.33.3-1.81.8
Pavlov. Cond. latency score1.52.42.4-1.51.5
Pavlov. Cond. lever contacts5.37.87.8-2.82.8
Pavlov. Cond. magazine entry number0.20.30.30.5-0.5
Pavlov. Cond. intertrial magazine entries0.30.70.7-0.80.8
Pavlov. Cond. lever-magazine prob. diff.1.72.62.6-1.61.6
Pavlov. Cond. response bias4.35.95.9-2.42.4
Time in closed arm before self-admin0.00.10.10.3-0.3
Time in closed arm after self-admin0.10.20.20.4-0.4
Time in open arm before self-admin1.92.42.41.5-1.5
Time in open arm after self-admin0.00.00.0-0.00.0
Bone: periosteal estimation2.86.76.7-2.62.6
Bone: periosteal perimeter2.24.34.3-2.12.1
Bone: post-yield work0.30.50.5-0.70.7
Progressive ratio test 1 active lever presses2.03.53.5-1.91.9
Progressive ratio test 1 breakpoint1.83.23.2-1.81.8
Progressive ratio test 1 inactive lever presses0.10.30.3-0.60.6
Progressive ratio test 2 active lever presses0.91.31.3-1.11.1
Progressive ratio test 2 breakpoint1.01.31.3-1.21.2
Progressive ratio test 2 inactive lever presses0.20.60.6-0.80.8
Incentive Sensitization - Responses0.10.30.3-0.50.5
Incentive Sensitization - Breakpoint0.10.20.2-0.50.5
Sum of active levers in priming session hrs 5-61.41.31.31.1-1.1
Progressive ratio0.72.22.2-1.51.5
Food seeking constrained by brief footshock0.50.60.6-0.80.8
Seeking ratio, punishment vs. effort0.20.40.40.6-0.6
Retroperitoneal fat weight4.620.620.64.5-4.5
Reaction time number correct0.20.60.6-0.70.7
Reaction time mean minus median0.31.81.81.3-1.3
Reaction time mean minus median AUC0.42.52.51.6-1.6
Reaction time num false alarms1.32.12.1-1.51.5
Reaction time num false alarms AUC1.84.04.0-2.02.0
Reaction time trials correct on left0.20.60.6-0.70.7
Reaction time trials on left0.20.50.5-0.70.7
Reaction time mean2.14.74.72.2-2.2
Reaction time mean AUC2.35.75.72.4-2.4
Median of all reaction times2.53.93.92.0-2.0
Reaction time omissions0.91.51.51.2-1.2
Reaction time false alarm rate1.11.61.6-1.31.3
Reaction time premature initiation rate0.60.90.90.9-0.9
Reaction time premature initiations0.10.20.20.5-0.5
Std. dev. reaction times0.72.22.21.5-1.5
Reaction time trials completed0.20.50.5-0.70.7
Reaction time trials AUC0.31.11.1-1.01.0
Run reversals in cocaine runway, females0.30.40.40.6-0.6
Run reversals in cocaine runway, males0.10.10.10.4-0.4
Latency to leave start box in cocaine runway0.30.40.40.7-0.7
Latency to leave start box in cocaine runway, F0.10.20.20.4-0.4
Latency to leave start box in cocaine runway, M0.90.90.90.9-0.9
Std. dev. time between licks in bursts1.22.22.2-1.51.5
Total sessions with >9 infusions1.41.71.7-1.31.3
Short access day 1 total inactive lever presses0.20.30.30.6-0.6
Short access day 10 total inactive lever presses0.31.71.71.3-1.3
Short access day 1 total infusions1.12.12.1-1.51.5
Short access day 10 total infusions2.13.43.4-1.81.8
Short access total infusions1.52.12.1-1.51.5
Short access day 1 locomotion0.10.20.2-0.50.5
Short access day 10 total locomotion0.00.10.1-0.30.3
Short access total locomotion0.20.30.3-0.50.5
One hour access (0.3 mA shock)1.92.32.3-1.51.5
Compulsive drug intake7.110.510.53.2-3.2
One hour access (shock baseline)3.69.39.3-3.13.1
Social response proportion0.40.50.50.7-0.7
Social responses1.92.52.5-1.61.6
Social time0.81.21.21.1-1.1
Soleus weight0.00.00.00.0-0.0
Bone: stiffness4.37.87.8-2.82.8
Tibialis anterior weight0.00.20.20.4-0.4
Time to tail flick, vehicle, before self-admin1.31.61.61.3-1.3
Time to tail flick, vehicle, after self-admin3.06.16.12.5-2.5
Time to tail flick, test, before self-admin0.70.80.80.9-0.9
Time to tail flick, test, after self-admin0.50.50.50.7-0.7
Delta time to tail flick, vehicle, before/after SA0.00.00.0-0.00.0
Delta time to tail flick, test, before/after SA0.20.30.30.5-0.5
Tibia length8.824.624.6-5.05.0
Ambulatory time before self-admin1.44.24.2-2.12.1
Ambulatory time after self-admin1.11.81.8-1.41.4
Bone: tissue strength0.20.20.2-0.50.5
Total heroin consumption0.30.40.40.6-0.6
Bone: trabecular number0.00.00.0-0.20.2
Bone: trabecular spacing0.00.00.00.1-0.1
Bone: trabecular thickness0.81.21.2-1.11.1
Bone: trabecular tissue density0.61.01.0-1.01.0
Water consumed over 24 hours1.63.13.1-1.81.8
Number of responses in last shaping day1.41.81.8-1.41.4