Hub : Genes

LOC134486366

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative TSS XR_010065195.1 0.05 0.03 7.9e-05 0.04 0.01 0.01 0.03 1.7e-05 3.0e-02 9.5e-03 8.0e-04
2 Liver alternative TSS XR_010065197.1 0.05 0.03 1.3e-04 0.04 0.01 0.01 0.02 2.9e-05 4.1e-02 1.3e-02 1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.40.70.70.8-0.8
Area under the delay curve0.10.10.1-0.30.3
BMI with tail0.10.30.30.6-0.6
BMI without tail0.41.31.31.2-1.2
Body weight1.04.34.32.1-2.1
Weight adjusted by age0.91.41.4-1.21.2
Bone surface1.32.32.31.5-1.5
Bone volume1.32.32.31.5-1.5
Breakpoint value in progressive ratio session3.54.24.2-2.12.1
Number of licking bursts0.00.00.00.2-0.2
Context. condit. distance diff. score0.10.10.10.4-0.4
Locomotion velocity, session 10.00.00.0-0.20.2
Locomotion distance, session 10.00.00.0-0.10.1
Locomotion velocity, session 21.31.61.6-1.21.2
Locomotion distance, session 20.71.01.01.0-1.0
Locomotion velocity, session 30.30.30.3-0.60.6
Locomotion distance, session 30.20.20.20.5-0.5
Stereotopy head waving bouts, day 31.41.71.71.3-1.3
Stereotopy head waving duration, day 30.40.50.50.7-0.7
Locomotion velocity, session 70.10.10.1-0.40.4
Locomotion distance, session 70.00.00.0-0.00.0
Stereotopy head waving bouts, day 70.40.40.40.6-0.6
Stereotopy head waving duration, day 70.40.50.50.7-0.7
Locomotion velocity, session 80.00.00.00.1-0.1
Locomotion distance, session 80.10.10.10.4-0.4
Degree of sensitization distance0.20.20.2-0.40.4
Degree of sensitization stereotypy0.00.00.00.1-0.1
Conditioned locomotion0.10.10.1-0.30.3
Cocaine response after cond. corrected2.32.82.8-1.71.7
Cocaine response after cond. not corrected0.40.50.5-0.70.7
Cocaine response before conditioning3.23.83.81.9-1.9
Saline control response0.10.10.1-0.40.4
Bone: connectivity density0.20.20.20.5-0.5
Bone: cortical apparent density0.10.20.20.4-0.4
Bone: cortical area6.19.49.43.1-3.1
Bone: cortical porosity3.63.93.92.0-2.0
Bone: cortical porosity5.35.75.72.4-2.4
Bone: cortical thickness4.16.86.82.6-2.6
Bone: cortical thickness6.37.47.42.7-2.7
Bone: cortical tissue density0.10.10.10.4-0.4
Condit. Reinf. active minus inactive responses7.78.68.62.9-2.9
Condit. Reinf. active-inactive response ratio2.22.42.41.5-1.5
Condit. Reinf. active responses5.77.17.12.7-2.7
Condit. Reinf. inactive responses1.72.12.11.4-1.4
Incentive salience index mean6.98.58.52.9-2.9
Condit. Reinf. lever presses0.91.31.31.2-1.2
Condit. Reinf. active minus inactive responses3.95.05.02.2-2.2
Condit. Reinf. active-inactive response ratio2.32.72.71.6-1.6
Condit. Reinf. active responses4.15.75.72.4-2.4
Condit. Reinf. inactive responses0.50.70.70.8-0.8
Condit. Reinf. lever presses6.28.68.62.9-2.9
Condit. Reinf. lever reinforcers received2.73.73.71.9-1.9
Conditioned reinforcement - actives2.13.63.61.9-1.9
Conditioned reinforcement - inactives0.00.00.00.1-0.1
Conditioned locomotion0.50.60.60.8-0.8
Patch foraging indifference point 0 sec0.20.40.40.6-0.6
Patch foraging indifference point AUC0.20.30.3-0.60.6
Delay disc. indifference point, 0s delay0.10.10.10.3-0.3
Delay disc. indifference point, 16s delay0.20.20.20.5-0.5
Delay disc. indifference point, 2s delay0.00.00.0-0.10.1
Delay disc. indifference point, 24s delay1.11.21.2-1.11.1
Delay disc. indifference point, 4s delay1.01.11.1-1.01.0
Delay disc. indifference point, 8s delay0.00.00.00.1-0.1
Indifference point function ln k0.20.40.40.6-0.6
Indifference point function log k0.20.40.40.6-0.6
Patch foraging total patch changes 0 sec0.10.10.10.3-0.3
Patch foraging total patch changes 12 sec2.33.03.01.7-1.7
Patch foraging total patch changes 18 sec1.72.52.51.6-1.6
Patch foraging total patch changes 24 sec1.62.72.71.7-1.7
Patch foraging total patch changes 6 sec0.10.20.2-0.40.4
Patch foraging time to switch 0 sec0.00.00.00.1-0.1
Patch foraging water rate 0 sec1.83.93.92.0-2.0
Patch foraging water rate 12 sec1.83.83.82.0-2.0
Patch foraging water rate 18 sec2.43.73.71.9-1.9
Patch foraging water rate 24 sec0.91.31.31.1-1.1
Patch foraging water rate 6 sec2.02.92.91.7-1.7
Seeking ratio, delayed vs. immediate footshock0.81.01.01.0-1.0
Distance traveled before self-admin3.14.14.12.0-2.0
Distance traveled after self-admin2.63.23.21.8-1.8
Extensor digitorum longus weight0.20.90.90.9-0.9
Bone: elastic displacement0.20.30.3-0.50.5
Bone: elastic work0.10.10.1-0.30.3
Bone: endosteal estimation0.51.01.01.0-1.0
Bone: endosteal perimeter0.51.11.11.1-1.1
Epididymis fat weight8.529.229.2-5.45.4
Delta time in closed arm before/after self-admin0.50.50.5-0.70.7
Delta time in open arm before/after self-admin0.70.70.70.9-0.9
Diff in mean of infusions in LGA sessions6.68.08.0-2.82.8
Delay discount exponential model param0.20.20.20.5-0.5
Extinction: sum of active levers before priming0.60.70.70.8-0.8
Active lever presses in extinction session 62.02.02.01.4-1.4
Bone: final force2.64.14.12.0-2.0
Bone: final moment2.33.73.71.9-1.9
Food consumed during 24 hour testing period2.43.33.31.8-1.8
Glucose1.01.51.51.2-1.2
Heart weight0.10.10.10.4-0.4
Delay discount hyperbolic model param0.20.30.30.5-0.5
Intermittent access intake day 1-15 change1.53.03.01.7-1.7
Intermittent access intake escalation1.22.52.51.6-1.6
Intermittent access intake escalation 20.81.01.01.0-1.0
Intermitt. access day 1 inactive lever presses0.83.03.0-1.71.7
Intermitt. access day 15 inactive lever presses0.20.40.4-0.60.6
Intermitt. access escalation Index0.00.00.00.0-0.0
Intermittent access day 1 total infusions0.00.10.10.2-0.2
Intermittent access day 15 total infusions1.62.42.41.6-1.6
Intermittent access terminal intake (last 3 days)2.12.82.81.7-1.7
Intermittent access total infusions1.41.71.71.3-1.3
Intermittent access day 1 locomotion0.60.80.8-0.90.9
Intermittent access day 15 total locomotion0.40.70.70.8-0.8
Intermittent access total locomotion0.30.30.30.6-0.6
Intermittent access standard deviation1.43.03.01.7-1.7
Left kidney weight0.63.03.01.7-1.7
Right kidney weight1.14.94.92.2-2.2
Cocaine induced anxiety0.71.01.0-1.01.0
Post-drug Anxiety0.10.10.10.4-0.4
Baseline Anxiety3.03.53.51.9-1.9
Tail length1.56.06.02.5-2.5
Length with tail1.46.06.02.4-2.4
Length without tail1.23.83.82.0-2.0
Times rat made contact with spout1.01.11.1-1.11.1
Lifetime Intake2.32.82.81.7-1.7
Liver weight, left0.61.11.11.0-1.0
Liver weight, right0.10.10.10.4-0.4
Locomotor activity2.94.54.52.1-2.1
Locomotor testing distance4.88.68.62.9-2.9
Locomotor testing rearing3.77.47.42.7-2.7
Locomotion in novel chamber0.10.10.10.3-0.3
Locomotion in novel chamber post-restriction0.71.21.21.1-1.1
Fecal boli incidents, locomotor time 11.31.91.9-1.41.4
Change in fecal boli incidents, locomotor task0.90.90.91.0-1.0
Time >=10cm from walls, locomotor time 10.30.40.40.6-0.6
Bouts of movement, locomotor time 15.05.65.6-2.42.4
Total resting periods, locomotor time 14.75.25.2-2.32.3
Rest time, locomotor task time 13.44.34.3-2.12.1
Distance moved, locomotor task time 14.16.16.12.5-2.5
Vertical activity count, locomotor time 10.51.21.21.1-1.1
Time >=10cm from walls, locomotor time 20.30.50.50.7-0.7
Bouts of movement, locomotor time 21.72.72.7-1.71.7
Total resting periods, locomotor time 21.93.43.4-1.81.8
Rest time, locomotor task time 21.62.02.0-1.41.4
Distance moved, locomotor task time 22.63.13.11.7-1.7
Vertical activity count, locomotor time 20.00.00.00.1-0.1
Light reinforcement 10.00.00.00.2-0.2
Light reinforcement 20.10.10.1-0.30.3
Bone: marrow area0.51.11.11.1-1.1
Bone: maximum diameter2.95.55.52.3-2.3
Bone: maximum force2.95.15.12.3-2.3
Bone: maximum moment2.84.84.82.2-2.2
Mean time between licks in bursts0.10.30.30.6-0.6
Mean num. licks in bursts0.30.50.5-0.70.7
Cd content in liver0.00.00.0-0.20.2
Co content in liver0.91.01.01.0-1.0
Cu content in liver0.10.10.1-0.30.3
Fe content in liver1.21.51.5-1.21.2
K content in liver0.00.00.00.2-0.2
Mg content in liver0.40.40.40.6-0.6
Mn content in liver6.97.67.62.8-2.8
Na content in liver1.92.12.11.4-1.4
Rb content in liver1.01.11.11.1-1.1
Se content in liver0.91.01.0-1.01.0
Sr content in liver0.80.70.70.8-0.8
Zn content in liver0.00.00.0-0.10.1
Bone: minimum diameter0.91.71.71.3-1.3
Time in familiar zone, hab. session 10.00.00.0-0.20.2
Time in novel zone, hab. session 10.50.50.5-0.70.7
Total zone transitions, hab. session 11.72.42.41.6-1.6
Total locomotion distance, hab. session 10.91.31.31.1-1.1
Locomotion velocity, hab. session 10.91.21.21.1-1.1
Time in familiar zone, hab. session 22.42.52.5-1.61.6
Time in novel zone, hab. session 22.52.52.51.6-1.6
Total zone transitions, hab. session 21.31.61.61.3-1.3
Total locomotion distance, hab. session 20.30.40.40.6-0.6
Locomotion velocity, hab. session 20.10.20.20.4-0.4
Novel to familiar place preference ratio0.00.00.00.0-0.0
Novelty place preference0.00.00.00.0-0.0
Time in novel zone, NPP test0.00.00.0-0.00.0
Total zone transitions, NPP test0.10.10.10.4-0.4
Total locomotion distance, NPP test0.50.70.70.8-0.8
Locomotion velocity, NPP test0.50.70.70.8-0.8
Intraocular pressure1.72.42.41.6-1.6
Delta distance traveled before/after self-admin0.50.60.6-0.70.7
Delta ambulatory time before/after self-admin0.10.10.10.3-0.3
Parametrial fat weight3.37.87.8-2.82.8
Pavlov. Cond. lever latency1.21.51.5-1.21.2
Pavlov. Cond. magazine entry latency0.20.20.20.4-0.4
Pavlov. Cond. change in total contacts1.51.61.61.3-1.3
Pavlov. Cond. index score1.11.41.41.2-1.2
Pavlov. Cond. latency score1.21.51.51.2-1.2
Pavlov. Cond. lever contacts2.02.42.41.5-1.5
Pavlov. Cond. magazine entry number0.40.50.5-0.70.7
Pavlov. Cond. intertrial magazine entries2.32.72.71.7-1.7
Pavlov. Cond. lever-magazine prob. diff.1.11.41.41.2-1.2
Pavlov. Cond. response bias0.50.60.60.8-0.8
Pavlov. Cond. lever latency5.87.97.9-2.82.8
Pavlov. Cond. magazine entry latency0.60.80.80.9-0.9
Pavlov. Cond. change in total contacts2.03.23.21.8-1.8
Pavlov. Cond. index score2.53.33.31.8-1.8
Pavlov. Cond. latency score1.82.42.41.5-1.5
Pavlov. Cond. lever contacts5.77.87.82.8-2.8
Pavlov. Cond. magazine entry number0.20.30.3-0.50.5
Pavlov. Cond. intertrial magazine entries0.50.70.70.8-0.8
Pavlov. Cond. lever-magazine prob. diff.1.92.62.61.6-1.6
Pavlov. Cond. response bias4.45.95.92.4-2.4
Time in closed arm before self-admin0.10.10.1-0.30.3
Time in closed arm after self-admin0.10.20.2-0.40.4
Time in open arm before self-admin2.22.42.4-1.51.5
Time in open arm after self-admin0.00.00.00.0-0.0
Bone: periosteal estimation3.26.76.72.6-2.6
Bone: periosteal perimeter2.54.34.32.1-2.1
Bone: post-yield work0.30.50.50.7-0.7
Progressive ratio test 1 active lever presses2.83.53.51.9-1.9
Progressive ratio test 1 breakpoint2.63.23.21.8-1.8
Progressive ratio test 1 inactive lever presses0.20.30.30.6-0.6
Progressive ratio test 2 active lever presses1.11.31.31.1-1.1
Progressive ratio test 2 breakpoint1.21.31.31.2-1.2
Progressive ratio test 2 inactive lever presses0.40.60.60.8-0.8
Incentive Sensitization - Responses0.20.30.30.5-0.5
Incentive Sensitization - Breakpoint0.20.20.20.5-0.5
Sum of active levers in priming session hrs 5-61.41.31.3-1.11.1
Progressive ratio1.42.22.21.5-1.5
Food seeking constrained by brief footshock0.50.60.60.8-0.8
Seeking ratio, punishment vs. effort0.30.40.4-0.60.6
Retroperitoneal fat weight4.820.620.6-4.54.5
Reaction time number correct0.30.60.60.7-0.7
Reaction time mean minus median0.71.81.8-1.31.3
Reaction time mean minus median AUC1.02.52.5-1.61.6
Reaction time num false alarms1.52.12.11.5-1.5
Reaction time num false alarms AUC2.64.04.02.0-2.0
Reaction time trials correct on left0.30.60.60.7-0.7
Reaction time trials on left0.30.50.50.7-0.7
Reaction time mean3.04.74.7-2.22.2
Reaction time mean AUC3.55.75.7-2.42.4
Median of all reaction times2.83.93.9-2.02.0
Reaction time omissions1.01.51.5-1.21.2
Reaction time false alarm rate1.11.61.61.3-1.3
Reaction time premature initiation rate0.60.90.9-0.90.9
Reaction time premature initiations0.10.20.2-0.50.5
Std. dev. reaction times1.22.22.2-1.51.5
Reaction time trials completed0.30.50.50.7-0.7
Reaction time trials AUC0.61.11.11.0-1.0
Run reversals in cocaine runway, females0.40.40.4-0.60.6
Run reversals in cocaine runway, males0.10.10.1-0.40.4
Latency to leave start box in cocaine runway0.40.40.4-0.70.7
Latency to leave start box in cocaine runway, F0.10.20.2-0.40.4
Latency to leave start box in cocaine runway, M0.90.90.9-0.90.9
Std. dev. time between licks in bursts1.62.22.21.5-1.5
Total sessions with >9 infusions1.41.71.71.3-1.3
Short access day 1 total inactive lever presses0.20.30.3-0.60.6
Short access day 10 total inactive lever presses0.71.71.7-1.31.3
Short access day 1 total infusions1.62.12.11.5-1.5
Short access day 10 total infusions2.73.43.41.8-1.8
Short access total infusions1.72.12.11.5-1.5
Short access day 1 locomotion0.20.20.20.5-0.5
Short access day 10 total locomotion0.00.10.10.3-0.3
Short access total locomotion0.20.30.30.5-0.5
One hour access (0.3 mA shock)2.02.32.31.5-1.5
Compulsive drug intake8.810.510.5-3.23.2
One hour access (shock baseline)6.19.39.33.1-3.1
Social response proportion0.40.50.5-0.70.7
Social responses1.92.52.51.6-1.6
Social time0.91.21.2-1.11.1
Soleus weight0.00.00.0-0.00.0
Bone: stiffness4.87.87.82.8-2.8
Tibialis anterior weight0.10.20.2-0.40.4
Time to tail flick, vehicle, before self-admin1.51.61.6-1.31.3
Time to tail flick, vehicle, after self-admin4.66.16.1-2.52.5
Time to tail flick, test, before self-admin0.80.80.8-0.90.9
Time to tail flick, test, after self-admin0.50.50.5-0.70.7
Delta time to tail flick, vehicle, before/after SA0.00.00.00.0-0.0
Delta time to tail flick, test, before/after SA0.30.30.3-0.50.5
Tibia length8.924.624.65.0-5.0
Ambulatory time before self-admin2.84.24.22.1-2.1
Ambulatory time after self-admin1.61.81.81.4-1.4
Bone: tissue strength0.20.20.20.5-0.5
Total heroin consumption0.30.40.4-0.60.6
Bone: trabecular number0.00.00.00.2-0.2
Bone: trabecular spacing0.00.00.0-0.10.1
Bone: trabecular thickness0.91.21.21.1-1.1
Bone: trabecular tissue density0.71.01.01.0-1.0
Water consumed over 24 hours2.33.13.11.8-1.8
Number of responses in last shaping day1.71.81.81.4-1.4