LOC134486165

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC134486165	0.28	0.1	0.0e+00	0.12	0.11	0.09	0.11	1.1e-12	8.9e-12	4.3e-10	4.3e-12
2	PL	gene expression	LOC134486165	0.03	0.02	5.4e-03	0.02	0.01	0.02	0.02	5.2e-03	8.8e-03	3.3e-03	4.7e-03
3	RMTg	gene expression	LOC134486165	0.2	0.11	8.5e-03	0.09	0.01	-0.01	0.02	2.7e-03	1.7e-01	6.2e-01	1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	1.0	1.9	2.9	-1.2	1.2	-1.7
Area under the delay curve	0.5	0.7	1.9	0.5	-1.4	-0.2
BMI with tail	6.4	22.2	33.4	-5.8	4.7	3.3
BMI without tail	2.5	13.5	17.1	-4.1	3.0	3.8
Body weight	9.9	43.3	63.5	-8.0	7.8	2.3
Weight adjusted by age	0.2	0.6	1.2	-0.2	0.8	1.1
Bone surface	0.2	0.3	0.5	-0.7	0.5	-0.4
Bone volume	0.5	1.0	1.3	-0.9	0.9	-1.1
Breakpoint value in progressive ratio session	0.3	0.5	1.4	0.1	-0.4	1.2
Number of licking bursts	0.4	1.2	1.2	-1.1	1.1	-1.1
Context. condit. distance diff. score	0.2	0.2	0.4	0.3	-0.7	-0.2
Locomotion velocity, session 1	1.7	1.9	4.4	1.1	-2.1	-0.3
Locomotion distance, session 1	2.3	2.9	5.5	1.5	-2.3	-0.9
Locomotion velocity, session 2	1.7	2.1	3.8	1.5	-1.9	-0.3
Locomotion distance, session 2	3.7	5.2	11.1	2.1	-3.3	-0.5
Locomotion velocity, session 3	1.3	1.5	2.2	0.7	-1.5	-1.3
Locomotion distance, session 3	0.4	0.5	0.7	0.2	-0.9	-0.8
Stereotopy head waving bouts, day 3	1.1	1.3	1.8	-1.2	1.4	-0.8
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.5	0.6	-0.0
Locomotion velocity, session 7	0.9	0.9	1.4	1.1	-0.5	-1.2
Locomotion distance, session 7	0.5	0.7	1.7	-0.0	-0.6	-1.3
Stereotopy head waving bouts, day 7	0.4	0.5	0.6	-0.8	0.7	0.6
Stereotopy head waving duration, day 7	0.1	0.2	0.2	-0.4	0.4	-0.3
Locomotion velocity, session 8	1.4	1.6	3.2	1.3	-1.8	-0.1
Locomotion distance, session 8	2.5	3.6	8.5	1.4	-2.9	-0.6
Degree of sensitization distance	0.1	0.1	0.2	-0.3	0.4	-0.1
Degree of sensitization stereotypy	0.4	0.5	1.4	-0.2	-0.0	1.2
Conditioned locomotion	2.6	3.1	3.7	-1.7	1.6	-1.9
Cocaine response after cond. corrected	0.5	0.8	1.3	0.8	-0.6	-1.1
Cocaine response after cond. not corrected	0.9	1.3	3.6	0.5	-0.1	-1.9
Cocaine response before conditioning	0.7	0.8	1.4	-0.5	0.9	-1.2
Saline control response	0.0	0.0	0.1	-0.3	0.1	-0.1
Bone: connectivity density	0.8	1.3	2.8	-0.8	0.7	-1.7
Bone: cortical apparent density	0.0	0.1	0.1	-0.2	0.3	-0.3
Bone: cortical area	2.8	4.6	6.0	-2.2	2.4	-1.7
Bone: cortical porosity	1.8	2.0	3.4	-1.8	1.4	-0.8
Bone: cortical porosity	2.2	2.4	4.2	-2.1	1.6	-0.7
Bone: cortical thickness	5.1	8.5	10.7	-2.9	3.3	-2.5
Bone: cortical thickness	2.0	2.5	2.6	-1.6	1.5	-1.6
Bone: cortical tissue density	0.0	0.0	0.0	0.0	0.2	-0.2
Condit. Reinf. active minus inactive responses	1.0	1.1	1.6	-1.3	1.3	-0.4
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.0	-0.6	1.0	-0.3
Condit. Reinf. active responses	0.1	0.2	0.3	-0.5	0.4	0.3
Condit. Reinf. inactive responses	0.6	0.8	1.2	0.4	-1.0	1.1
Incentive salience index mean	0.0	0.1	0.1	-0.2	0.3	-0.0
Condit. Reinf. lever presses	0.8	1.2	1.4	1.1	-0.9	1.2
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.2	0.2	-0.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.2	-0.2	0.5
Condit. Reinf. active responses	0.1	0.2	0.5	-0.0	-0.1	0.7
Condit. Reinf. inactive responses	0.1	0.2	0.4	-0.1	0.4	0.7
Condit. Reinf. lever presses	1.1	1.6	3.5	0.5	-1.0	1.9
Condit. Reinf. lever reinforcers received	0.2	0.3	0.8	0.3	-0.4	0.9
Conditioned reinforcement - actives	0.5	1.9	3.0	0.1	-1.7	-1.6
Conditioned reinforcement - inactives	0.2	0.6	1.5	0.2	-0.5	-1.2
Conditioned locomotion	1.5	2.2	3.4	1.2	-1.8	-1.4
Patch foraging indifference point 0 sec	0.2	0.5	1.3	1.2	-0.4	0.2
Patch foraging indifference point AUC	1.0	2.5	5.8	2.4	-1.3	-0.2
Delay disc. indifference point, 0s delay	0.2	0.2	0.5	-0.0	-0.7	0.3
Delay disc. indifference point, 16s delay	0.5	0.7	1.0	0.8	-1.0	-0.6
Delay disc. indifference point, 2s delay	0.5	0.6	1.3	-0.0	-1.2	0.7
Delay disc. indifference point, 24s delay	0.5	0.9	2.1	-0.1	-0.7	-1.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.2	-0.2	0.4
Delay disc. indifference point, 8s delay	0.6	0.9	2.4	0.4	-1.6	-0.4
Indifference point function ln k	0.7	2.0	4.9	-2.2	1.0	-0.4
Indifference point function log k	0.7	2.0	4.9	-2.2	1.0	-0.4
Patch foraging total patch changes 0 sec	0.4	1.1	2.5	1.6	-0.8	0.4
Patch foraging total patch changes 12 sec	0.6	0.8	1.8	1.3	-0.4	0.7
Patch foraging total patch changes 18 sec	2.0	4.6	10.4	3.2	-1.7	0.7
Patch foraging total patch changes 24 sec	0.8	2.8	6.4	2.5	-1.3	0.7
Patch foraging total patch changes 6 sec	0.8	1.4	3.6	1.9	-0.4	0.6
Patch foraging time to switch 0 sec	0.7	2.6	4.4	-2.1	1.8	0.3
Patch foraging water rate 0 sec	1.3	4.7	8.7	2.9	-2.3	0.3
Patch foraging water rate 12 sec	0.5	1.9	2.8	1.5	-1.7	-0.8
Patch foraging water rate 18 sec	0.9	1.9	3.9	0.7	-1.2	-2.0
Patch foraging water rate 24 sec	0.6	0.9	1.7	0.8	-1.3	-0.7
Patch foraging water rate 6 sec	0.6	0.9	2.4	0.6	0.0	-1.6
Seeking ratio, delayed vs. immediate footshock	0.6	0.9	2.0	-1.4	0.7	-0.5
Distance traveled before self-admin	1.7	3.7	8.9	1.2	-0.8	3.0
Distance traveled after self-admin	0.3	0.5	1.0	1.0	-0.4	-0.5
Extensor digitorum longus weight	0.1	0.6	1.2	-1.1	0.4	0.6
Bone: elastic displacement	0.1	0.1	0.4	-0.1	0.6	-0.2
Bone: elastic work	1.7	2.2	3.5	-1.9	1.7	0.5
Bone: endosteal estimation	0.4	0.9	2.0	-0.8	0.2	1.4
Bone: endosteal perimeter	0.1	0.1	0.2	0.1	-0.4	0.5
Epididymis fat weight	4.9	24.7	38.0	-6.2	5.7	2.0
Delta time in closed arm before/after self-admin	0.2	0.1	0.3	0.6	-0.1	0.3
Delta time in open arm before/after self-admin	1.4	1.7	2.7	-1.5	1.7	0.4
Diff in mean of infusions in LGA sessions	1.0	1.7	3.8	0.8	-0.9	1.9
Delay discount exponential model param	0.5	0.7	1.7	-0.5	1.3	0.4
Extinction: sum of active levers before priming	0.8	1.1	1.8	0.9	-0.8	1.4
Active lever presses in extinction session 6	0.9	0.9	1.5	-1.2	0.9	-0.6
Bone: final force	1.9	3.0	4.6	-2.1	1.9	-0.9
Bone: final moment	2.1	3.5	5.3	-2.3	2.0	-1.1
Food consumed during 24 hour testing period	2.1	4.1	4.7	-2.2	2.0	-1.9
Glucose	0.7	1.0	1.7	-0.8	1.3	0.9
Heart weight	1.4	2.3	5.0	-2.2	1.3	0.2
Delay discount hyperbolic model param	0.3	0.4	1.1	-0.3	1.0	0.2
Intermittent access intake day 1-15 change	0.1	0.8	1.2	-0.1	-1.1	1.1
Intermittent access intake escalation	0.1	0.8	1.4	-0.3	-1.2	0.9
Intermittent access intake escalation 2	0.5	0.9	1.7	-0.7	-0.7	1.3
Intermitt. access day 1 inactive lever presses	0.1	1.5	4.3	-0.0	0.5	2.1
Intermitt. access day 15 inactive lever presses	0.2	0.9	1.5	-1.1	1.2	-0.2
Intermitt. access escalation Index	0.1	0.4	1.1	-0.4	1.1	-0.3
Intermittent access day 1 total infusions	0.6	1.9	3.5	-1.4	0.7	-1.9
Intermittent access day 15 total infusions	0.6	1.5	2.5	-1.6	0.2	-1.4
Intermittent access terminal intake (last 3 days)	0.7	1.3	2.8	-1.7	0.6	-0.8
Intermittent access total infusions	1.6	1.9	2.7	-1.5	0.8	-1.6
Intermittent access day 1 locomotion	0.7	1.3	3.2	-0.5	-0.6	-1.8
Intermittent access day 15 total locomotion	0.4	1.7	4.2	-0.9	0.1	-2.0
Intermittent access total locomotion	0.9	1.1	2.5	0.1	-0.9	-1.6
Intermittent access standard deviation	0.1	0.4	1.1	0.4	-1.1	-0.1
Left kidney weight	0.8	6.8	11.3	-3.4	3.0	0.2
Right kidney weight	0.5	3.7	7.3	-2.7	2.0	0.0
Cocaine induced anxiety	0.2	0.4	0.9	0.6	-0.9	-0.1
Post-drug Anxiety	0.3	0.3	0.7	-0.3	0.5	0.8
Baseline Anxiety	1.4	2.4	3.5	-0.8	1.9	1.8
Tail length	0.6	3.0	4.9	-2.0	2.2	-0.3
Length with tail	2.7	11.8	19.5	-4.0	4.4	-0.0
Length without tail	2.9	15.2	22.6	-4.8	4.7	-1.0
Times rat made contact with spout	0.5	0.6	1.7	0.1	-0.1	1.3
Lifetime Intake	0.8	1.0	2.1	-1.0	0.4	-1.4
Liver weight, left	0.9	1.6	2.2	-1.1	1.2	1.5
Liver weight, right	1.8	3.1	4.9	-2.0	2.2	0.6
Locomotor activity	1.1	1.8	3.8	0.2	-1.2	2.0
Locomotor testing distance	0.6	1.4	2.5	1.0	-1.6	0.9
Locomotor testing rearing	0.4	1.4	1.7	1.3	-1.2	1.0
Locomotion in novel chamber	0.4	0.5	1.1	-0.1	0.6	-1.0
Locomotion in novel chamber post-restriction	0.2	0.7	1.5	0.8	0.0	-1.2
Fecal boli incidents, locomotor time 1	0.3	0.7	1.6	0.7	-1.3	-0.0
Change in fecal boli incidents, locomotor task	1.5	1.6	2.9	-0.5	1.7	-1.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	0.4	0.2
Bouts of movement, locomotor time 1	0.3	0.4	1.0	0.4	-1.0	-0.5
Total resting periods, locomotor time 1	0.5	0.5	1.1	0.6	-1.0	-0.4
Rest time, locomotor task time 1	0.0	0.1	0.2	-0.1	-0.4	0.0
Distance moved, locomotor task time 1	0.1	0.4	1.1	0.2	0.2	-1.1
Vertical activity count, locomotor time 1	0.1	0.9	1.1	-1.0	1.0	-0.8
Time >=10cm from walls, locomotor time 2	1.0	2.8	4.6	-2.1	1.9	0.6
Bouts of movement, locomotor time 2	0.7	2.3	3.0	1.2	-1.5	1.7
Total resting periods, locomotor time 2	0.6	2.6	4.3	1.2	-1.5	2.1
Rest time, locomotor task time 2	0.5	0.8	1.1	0.6	-1.1	1.0
Distance moved, locomotor task time 2	0.6	0.8	2.2	0.2	0.4	-1.5
Vertical activity count, locomotor time 2	0.2	0.5	1.2	-0.5	0.4	-1.1
Light reinforcement 1	0.1	0.5	1.0	0.5	-1.0	-0.4
Light reinforcement 2	0.1	0.3	0.6	0.4	-0.8	-0.4
Bone: marrow area	0.3	0.8	1.8	-0.8	0.2	1.4
Bone: maximum diameter	0.4	0.8	1.1	-1.0	1.0	-0.5
Bone: maximum force	1.6	3.1	5.0	-2.2	1.8	-0.9
Bone: maximum moment	1.9	3.7	6.0	-2.5	2.0	-1.0
Mean time between licks in bursts	0.8	5.0	8.1	-1.0	2.9	-2.4
Mean num. licks in bursts	0.3	0.9	1.7	0.8	-0.6	1.3
Cd content in liver	0.6	0.7	1.2	-0.6	1.1	-0.7
Co content in liver	2.2	2.6	5.5	-0.2	1.5	-2.4
Cu content in liver	0.1	0.2	0.3	0.3	0.4	-0.5
Fe content in liver	1.6	2.0	3.2	-1.8	1.6	-0.3
K content in liver	2.4	2.4	3.4	1.9	-1.5	1.2
Mg content in liver	0.1	0.1	0.3	0.1	0.4	0.5
Mn content in liver	1.4	1.5	3.4	1.8	-1.1	-0.1
Na content in liver	0.3	0.4	0.5	0.7	-0.7	0.5
Rb content in liver	0.8	0.9	1.2	-0.9	1.1	0.8
Se content in liver	2.4	2.9	4.8	-1.9	2.2	0.1
Sr content in liver	1.0	0.9	1.6	1.2	-0.8	-0.6
Zn content in liver	1.8	2.1	2.2	-1.4	1.5	-1.4
Bone: minimum diameter	0.9	1.7	2.7	-1.7	1.5	-0.5
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.4	0.8	-0.5
Time in novel zone, hab. session 1	0.7	0.7	1.6	0.5	-0.6	1.3
Total zone transitions, hab. session 1	0.2	0.3	0.6	0.2	-0.4	-0.8
Total locomotion distance, hab. session 1	0.5	0.7	1.2	0.9	-1.1	-0.1
Locomotion velocity, hab. session 1	0.4	0.5	0.9	0.5	-0.9	-0.6
Time in familiar zone, hab. session 2	0.4	0.4	1.2	0.3	-1.1	-0.1
Time in novel zone, hab. session 2	0.3	0.3	0.6	-0.2	0.8	0.5
Total zone transitions, hab. session 2	0.2	0.3	0.7	0.2	-0.9	0.1
Total locomotion distance, hab. session 2	1.9	2.5	5.1	1.4	-2.3	0.7
Locomotion velocity, hab. session 2	1.9	2.5	4.9	1.6	-2.2	0.2
Novel to familiar place preference ratio	0.3	0.3	0.7	-0.9	0.3	0.4
Novelty place preference	0.4	0.5	1.1	-1.1	0.6	0.2
Time in novel zone, NPP test	0.5	0.6	1.2	-1.1	0.7	0.5
Total zone transitions, NPP test	1.0	1.5	2.4	1.4	-1.6	0.4
Total locomotion distance, NPP test	3.0	4.2	8.2	2.0	-2.9	0.6
Locomotion velocity, NPP test	2.7	3.9	7.4	2.1	-2.7	0.0
Intraocular pressure	0.7	1.2	2.3	-0.7	0.8	-1.5
Delta distance traveled before/after self-admin	2.4	2.6	7.7	0.3	-0.0	-2.8
Delta ambulatory time before/after self-admin	1.5	2.5	7.5	0.2	0.1	-2.7
Parametrial fat weight	10.2	24.0	29.4	-5.4	5.0	4.2
Pavlov. Cond. lever latency	1.0	1.3	2.7	-1.7	1.0	-0.5
Pavlov. Cond. magazine entry latency	0.8	1.0	1.5	-1.1	0.7	1.2
Pavlov. Cond. change in total contacts	0.3	0.3	0.7	0.5	-0.0	0.8
Pavlov. Cond. index score	0.1	0.2	0.4	0.2	0.2	0.7
Pavlov. Cond. latency score	0.1	0.2	0.4	0.6	-0.1	0.4
Pavlov. Cond. lever contacts	0.7	0.8	1.4	1.2	-0.6	0.8
Pavlov. Cond. magazine entry number	0.7	0.9	1.8	0.7	-0.7	-1.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.5	0.5	-0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.9	0.1	-0.0	1.0
Pavlov. Cond. response bias	0.5	0.6	1.2	-0.5	0.6	1.1
Pavlov. Cond. lever latency	0.7	1.0	2.0	0.8	-0.6	-1.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.1	0.1	0.5
Pavlov. Cond. change in total contacts	0.4	1.0	2.9	-0.2	0.4	1.7
Pavlov. Cond. index score	0.5	0.7	1.5	-0.6	0.7	1.2
Pavlov. Cond. latency score	0.3	0.5	1.0	-0.5	0.6	1.0
Pavlov. Cond. lever contacts	0.7	1.0	2.2	-0.8	0.5	1.5
Pavlov. Cond. magazine entry number	0.2	0.3	0.3	0.5	-0.6	-0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	0.1	-0.6	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	1.0	1.8	-0.7	0.8	1.3
Pavlov. Cond. response bias	0.7	0.9	1.6	-0.8	0.7	1.3
Time in closed arm before self-admin	0.5	0.8	1.6	-0.7	0.7	-1.2
Time in closed arm after self-admin	0.8	0.9	2.6	0.0	0.4	-1.6
Time in open arm before self-admin	0.2	0.3	0.3	0.6	-0.5	0.5
Time in open arm after self-admin	0.6	0.6	1.5	-0.3	0.5	1.2
Bone: periosteal estimation	0.7	1.7	3.3	-1.8	1.3	-0.0
Bone: periosteal perimeter	0.2	0.4	0.6	-0.4	0.6	-0.8
Bone: post-yield work	0.7	1.2	2.3	-1.5	0.8	-0.8
Progressive ratio test 1 active lever presses	0.0	0.1	0.1	-0.2	-0.3	-0.3
Progressive ratio test 1 breakpoint	0.0	0.1	0.1	-0.3	-0.2	-0.3
Progressive ratio test 1 inactive lever presses	0.6	1.6	2.6	0.7	-1.3	1.6
Progressive ratio test 2 active lever presses	0.1	0.2	0.6	-0.2	-0.8	0.0
Progressive ratio test 2 breakpoint	0.2	0.2	0.6	-0.2	-0.8	-0.1
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	-0.4	-0.2	-0.1
Incentive Sensitization - Responses	0.1	0.1	0.3	0.3	-0.6	0.2
Incentive Sensitization - Breakpoint	0.1	0.2	0.4	0.4	-0.7	0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.4	-0.1	0.4
Progressive ratio	0.2	0.5	1.3	-0.2	0.3	-1.1
Food seeking constrained by brief footshock	3.1	3.9	6.0	2.4	-2.2	-1.0
Seeking ratio, punishment vs. effort	0.5	1.1	1.8	1.3	-1.2	0.3
Retroperitoneal fat weight	12.3	54.9	69.7	-8.3	8.3	5.2
Reaction time number correct	0.1	0.5	1.0	1.0	-0.7	-0.2
Reaction time mean minus median	0.2	1.4	2.5	-0.9	0.9	1.6
Reaction time mean minus median AUC	0.2	1.0	1.2	-0.8	1.1	1.1
Reaction time num false alarms	1.5	2.5	7.4	-0.3	0.1	-2.7
Reaction time num false alarms AUC	0.7	1.5	4.6	0.1	-0.2	-2.1
Reaction time trials correct on left	0.1	0.5	1.0	1.0	-0.7	-0.2
Reaction time trials on left	0.1	0.5	1.0	1.0	-0.7	-0.1
Reaction time mean	0.8	1.7	4.2	-0.8	0.4	2.1
Reaction time mean AUC	0.6	1.4	3.0	-1.0	0.6	1.7
Median of all reaction times	0.8	1.3	3.3	-0.7	0.2	1.8
Reaction time omissions	0.4	0.6	1.7	0.1	0.2	1.3
Reaction time false alarm rate	0.8	1.2	3.4	-0.2	0.1	-1.8
Reaction time premature initiation rate	0.5	0.8	1.6	-0.7	0.4	-1.3
Reaction time premature initiations	0.1	0.4	1.3	-0.0	-0.1	-1.2
Std. dev. reaction times	0.5	1.8	4.2	-0.8	0.7	2.0
Reaction time trials completed	0.1	0.5	1.0	1.0	-0.7	-0.1
Reaction time trials AUC	0.1	0.5	1.0	1.0	-0.7	-0.0
Run reversals in cocaine runway, females	0.3	0.3	0.7	-0.4	0.8	-0.3
Run reversals in cocaine runway, males	0.2	0.2	0.6	0.2	-0.3	0.8
Latency to leave start box in cocaine runway	1.7	2.3	3.4	-1.9	1.0	-1.5
Latency to leave start box in cocaine runway, F	3.5	4.3	6.2	-2.5	1.9	-1.8
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	0.2	-0.7	-0.3
Std. dev. time between licks in bursts	0.6	1.2	2.4	-0.0	1.1	-1.5
Total sessions with >9 infusions	0.3	0.4	1.0	0.3	-1.0	-0.0
Short access day 1 total inactive lever presses	0.4	0.8	1.3	-1.1	0.2	-1.1
Short access day 10 total inactive lever presses	0.2	1.4	1.9	-1.3	0.8	1.4
Short access day 1 total infusions	0.5	1.1	1.5	0.5	-1.2	-1.2
Short access day 10 total infusions	0.1	0.2	0.6	0.1	-0.8	0.0
Short access total infusions	0.2	0.3	0.8	-0.1	-0.2	-0.9
Short access day 1 locomotion	0.4	0.7	1.3	0.6	-1.1	0.6
Short access day 10 total locomotion	0.7	2.9	5.3	1.7	-2.3	0.8
Short access total locomotion	1.8	2.7	5.7	1.5	-2.4	0.3
One hour access (0.3 mA shock)	0.6	0.7	1.8	0.6	-1.3	-0.0
Compulsive drug intake	0.8	1.2	3.0	1.7	-0.7	-0.1
One hour access (shock baseline)	0.3	0.8	1.4	-1.2	0.1	-1.1
Social response proportion	1.3	1.7	2.2	-1.5	0.8	1.5
Social responses	0.1	0.1	0.2	0.0	-0.5	0.3
Social time	0.3	0.4	0.7	-0.8	-0.0	0.8
Soleus weight	0.1	0.2	0.5	-0.3	0.7	-0.3
Bone: stiffness	1.3	2.4	3.4	-1.9	1.5	-1.2
Tibialis anterior weight	0.6	2.2	3.4	-1.8	1.5	1.0
Time to tail flick, vehicle, before self-admin	4.2	5.1	8.7	-2.6	2.9	-0.1
Time to tail flick, vehicle, after self-admin	0.4	0.7	1.2	-0.9	1.1	0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.1	-0.2	-0.4
Time to tail flick, test, after self-admin	0.4	0.4	1.1	-1.0	0.1	-0.4
Delta time to tail flick, vehicle, before/after SA	0.7	0.8	1.3	1.1	-1.1	0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.3	-0.1	0.5
Tibia length	6.2	17.3	25.5	-4.9	5.1	-1.4
Ambulatory time before self-admin	1.0	2.9	7.8	0.9	-0.3	2.8
Ambulatory time after self-admin	0.4	0.6	1.0	1.0	-0.3	-0.8
Bone: tissue strength	0.1	0.1	0.2	-0.2	0.5	-0.3
Total heroin consumption	0.2	0.3	0.5	0.5	-0.1	0.7
Bone: trabecular number	0.9	1.6	2.4	-1.0	1.3	-1.5
Bone: trabecular spacing	0.4	0.6	1.6	0.2	0.1	1.3
Bone: trabecular thickness	1.2	1.7	2.4	-1.0	1.5	-1.3
Bone: trabecular tissue density	0.1	0.2	0.3	-0.5	0.6	0.0
Water consumed over 24 hours	0.1	0.1	0.2	-0.4	-0.2	-0.4
Number of responses in last shaping day	0.5	0.6	1.0	0.1	-1.0	-1.0