Hub : Genes

LOC134486151

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression LOC134486151 0.03 0.02 2.7e-03 0.03 0.02 0.02 0.02 1.4e-03 3.0e-03 9.0e-03 3.6e-03
2 Eye gene expression LOC134486151 0.34 0.19 4.8e-03 0.02 -0.02 -0.01 -0 1.7e-01 8.8e-01 4.1e-01 3.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.50.91.50.6-1.2
Area under the delay curve0.30.30.5-0.30.7
BMI with tail0.10.50.50.7-0.7
BMI without tail2.26.67.52.7-2.4
Body weight3.113.415.84.0-3.3
Weight adjusted by age2.13.24.42.1-1.4
Bone surface0.61.01.20.9-1.1
Bone volume0.51.01.20.9-1.1
Breakpoint value in progressive ratio session2.53.03.21.8-1.7
Number of licking bursts0.10.20.4-0.30.6
Context. condit. distance diff. score0.00.00.0-0.1-0.2
Locomotion velocity, session 10.20.20.40.6-0.4
Locomotion distance, session 10.20.20.30.4-0.5
Locomotion velocity, session 20.00.00.1-0.30.0
Locomotion distance, session 21.52.02.71.2-1.6
Locomotion velocity, session 31.31.51.71.3-1.1
Locomotion distance, session 37.27.88.02.8-2.8
Stereotopy head waving bouts, day 31.31.51.8-1.11.3
Stereotopy head waving duration, day 31.11.31.6-1.01.3
Locomotion velocity, session 70.80.91.00.9-1.0
Locomotion distance, session 70.81.11.70.6-1.3
Stereotopy head waving bouts, day 70.30.40.60.8-0.4
Stereotopy head waving duration, day 70.10.10.20.4-0.0
Locomotion velocity, session 80.30.40.60.4-0.8
Locomotion distance, session 81.82.53.41.3-1.8
Degree of sensitization distance2.12.22.8-1.71.2
Degree of sensitization stereotypy2.12.32.91.7-1.3
Conditioned locomotion3.23.74.82.2-1.6
Cocaine response after cond. corrected0.10.10.2-0.40.3
Cocaine response after cond. not corrected0.10.20.2-0.50.3
Cocaine response before conditioning0.10.10.1-0.40.2
Saline control response6.89.111.23.3-2.6
Bone: connectivity density0.20.30.50.2-0.7
Bone: cortical apparent density1.11.51.81.3-1.1
Bone: cortical area3.55.46.02.4-2.2
Bone: cortical porosity0.00.00.10.30.1
Bone: cortical porosity0.30.30.50.7-0.4
Bone: cortical thickness1.82.93.11.8-1.7
Bone: cortical thickness0.40.50.50.7-0.7
Bone: cortical tissue density0.91.21.41.2-1.0
Condit. Reinf. active minus inactive responses1.01.21.41.0-1.2
Condit. Reinf. active-inactive response ratio1.01.11.31.0-1.1
Condit. Reinf. active responses0.60.70.70.9-0.8
Condit. Reinf. inactive responses0.00.00.00.00.1
Incentive salience index mean0.40.50.50.7-0.7
Condit. Reinf. lever presses0.00.00.10.3-0.0
Condit. Reinf. active minus inactive responses3.14.04.51.9-2.1
Condit. Reinf. active-inactive response ratio2.83.23.31.7-1.8
Condit. Reinf. active responses4.86.77.52.4-2.7
Condit. Reinf. inactive responses0.70.91.00.8-1.0
Condit. Reinf. lever presses1.52.02.21.5-1.4
Condit. Reinf. lever reinforcers received3.65.05.52.1-2.3
Conditioned reinforcement - actives0.00.00.1-0.2-0.0
Conditioned reinforcement - inactives0.10.10.10.3-0.2
Conditioned locomotion0.20.20.4-0.20.6
Patch foraging indifference point 0 sec0.00.10.10.30.2
Patch foraging indifference point AUC1.01.41.91.0-1.4
Delay disc. indifference point, 0s delay2.93.24.0-1.52.0
Delay disc. indifference point, 16s delay0.60.71.0-0.71.0
Delay disc. indifference point, 2s delay0.00.00.1-0.00.3
Delay disc. indifference point, 24s delay2.02.32.3-1.51.5
Delay disc. indifference point, 4s delay0.10.10.20.4-0.1
Delay disc. indifference point, 8s delay0.30.40.5-0.40.7
Indifference point function ln k0.00.10.10.3-0.1
Indifference point function log k0.00.10.10.3-0.1
Patch foraging total patch changes 0 sec0.10.10.20.40.1
Patch foraging total patch changes 12 sec0.30.40.60.7-0.5
Patch foraging total patch changes 18 sec0.50.80.8-0.80.9
Patch foraging total patch changes 24 sec1.11.92.4-1.21.6
Patch foraging total patch changes 6 sec0.50.70.80.9-0.8
Patch foraging time to switch 0 sec1.63.23.4-1.71.8
Patch foraging water rate 0 sec3.57.37.72.8-2.6
Patch foraging water rate 12 sec0.10.20.40.2-0.7
Patch foraging water rate 18 sec0.40.60.70.7-0.8
Patch foraging water rate 24 sec0.60.90.90.9-1.0
Patch foraging water rate 6 sec2.13.03.51.9-1.6
Seeking ratio, delayed vs. immediate footshock0.00.00.0-0.20.2
Distance traveled before self-admin4.05.35.62.4-2.2
Distance traveled after self-admin1.82.32.71.6-1.3
Extensor digitorum longus weight0.00.10.10.4-0.3
Bone: elastic displacement0.00.10.10.0-0.3
Bone: elastic work0.00.00.10.1-0.2
Bone: endosteal estimation0.40.81.31.1-0.6
Bone: endosteal perimeter2.04.35.02.2-1.9
Epididymis fat weight0.10.20.5-0.10.7
Delta time in closed arm before/after self-admin0.80.70.8-0.90.8
Delta time in open arm before/after self-admin0.60.60.60.7-0.8
Diff in mean of infusions in LGA sessions0.30.40.60.4-0.7
Delay discount exponential model param0.20.20.40.3-0.6
Extinction: sum of active levers before priming1.82.02.31.3-1.5
Active lever presses in extinction session 60.00.00.10.10.3
Bone: final force3.35.26.42.5-2.0
Bone: final moment2.53.95.02.2-1.7
Food consumed during 24 hour testing period0.81.21.3-1.01.2
Glucose0.00.10.10.3-0.2
Heart weight3.55.46.02.2-2.5
Delay discount hyperbolic model param0.20.20.40.2-0.6
Intermittent access intake day 1-15 change0.10.20.30.5-0.2
Intermittent access intake escalation0.10.10.20.5-0.2
Intermittent access intake escalation 20.10.10.10.3-0.3
Intermitt. access day 1 inactive lever presses0.10.30.40.7-0.4
Intermitt. access day 15 inactive lever presses0.20.40.7-0.40.8
Intermitt. access escalation Index0.30.40.70.3-0.8
Intermittent access day 1 total infusions0.00.00.0-0.00.2
Intermittent access day 15 total infusions0.00.00.00.2-0.1
Intermittent access terminal intake (last 3 days)0.00.00.00.2-0.2
Intermittent access total infusions0.00.00.00.1-0.2
Intermittent access day 1 locomotion0.10.10.2-0.40.1
Intermittent access day 15 total locomotion0.00.00.00.20.2
Intermittent access total locomotion0.10.10.20.4-0.3
Intermittent access standard deviation0.10.30.40.6-0.5
Left kidney weight0.00.00.10.20.2
Right kidney weight0.00.00.00.20.0
Cocaine induced anxiety4.15.96.1-2.42.5
Post-drug Anxiety3.23.43.5-1.81.9
Baseline Anxiety0.20.20.30.4-0.5
Tail length3.714.317.34.2-3.4
Length with tail5.222.727.45.2-4.2
Length without tail1.96.17.82.8-2.1
Times rat made contact with spout0.00.00.1-0.10.3
Lifetime Intake0.10.10.20.4-0.2
Liver weight, left0.71.11.51.2-0.9
Liver weight, right0.20.40.60.8-0.4
Locomotor activity0.40.60.90.5-0.9
Locomotor testing distance0.00.10.1-0.30.2
Locomotor testing rearing0.20.50.50.6-0.7
Locomotion in novel chamber0.00.00.00.00.2
Locomotion in novel chamber post-restriction0.61.01.11.0-1.0
Fecal boli incidents, locomotor time 10.10.10.10.1-0.4
Change in fecal boli incidents, locomotor task0.30.30.4-0.40.6
Time >=10cm from walls, locomotor time 10.10.10.10.3-0.4
Bouts of movement, locomotor time 11.71.92.0-1.41.4
Total resting periods, locomotor time 11.31.41.5-1.21.2
Rest time, locomotor task time 10.10.20.3-0.50.3
Distance moved, locomotor task time 10.00.00.00.00.0
Vertical activity count, locomotor time 10.00.00.10.3-0.0
Time >=10cm from walls, locomotor time 20.00.00.0-0.00.2
Bouts of movement, locomotor time 20.30.50.6-0.70.8
Total resting periods, locomotor time 20.20.40.4-0.70.6
Rest time, locomotor task time 20.10.10.3-0.5-0.0
Distance moved, locomotor task time 20.00.00.1-0.00.3
Vertical activity count, locomotor time 20.00.10.10.3-0.2
Light reinforcement 10.61.61.91.4-1.1
Light reinforcement 20.50.70.91.0-0.7
Bone: marrow area0.30.81.11.1-0.6
Bone: maximum diameter4.37.98.72.9-2.7
Bone: maximum force0.81.42.01.4-0.9
Bone: maximum moment0.40.61.01.0-0.5
Mean time between licks in bursts0.00.00.1-0.10.3
Mean num. licks in bursts0.10.10.10.2-0.4
Cd content in liver2.62.93.51.5-1.9
Co content in liver2.73.13.21.8-1.7
Cu content in liver3.54.24.32.1-2.0
Fe content in liver0.10.10.20.1-0.4
K content in liver0.70.70.80.7-0.9
Mg content in liver4.04.14.22.0-2.0
Mn content in liver3.03.43.41.8-1.8
Na content in liver0.50.50.7-0.60.8
Rb content in liver4.24.95.52.1-2.3
Se content in liver1.51.71.81.3-1.3
Sr content in liver0.30.30.40.7-0.3
Zn content in liver1.61.82.21.5-1.2
Bone: minimum diameter1.52.83.31.8-1.5
Time in familiar zone, hab. session 11.11.11.4-1.20.8
Time in novel zone, hab. session 10.40.40.50.7-0.6
Total zone transitions, hab. session 10.20.30.60.3-0.8
Total locomotion distance, hab. session 10.10.10.3-0.0-0.5
Locomotion velocity, hab. session 10.10.10.20.1-0.5
Time in familiar zone, hab. session 21.31.41.4-1.21.1
Time in novel zone, hab. session 21.41.41.51.2-1.1
Total zone transitions, hab. session 22.53.23.51.7-1.9
Total locomotion distance, hab. session 20.50.70.80.8-0.9
Locomotion velocity, hab. session 20.20.20.30.4-0.5
Novel to familiar place preference ratio0.20.20.3-0.50.3
Novelty place preference0.40.40.5-0.70.5
Time in novel zone, NPP test0.20.20.3-0.50.4
Total zone transitions, NPP test0.20.20.30.4-0.5
Total locomotion distance, NPP test0.10.10.20.3-0.4
Locomotion velocity, NPP test0.00.00.0-0.0-0.1
Intraocular pressure0.00.00.10.1-0.3
Delta distance traveled before/after self-admin0.10.10.20.4-0.1
Delta ambulatory time before/after self-admin0.50.60.8-0.70.9
Parametrial fat weight0.20.50.6-0.70.8
Pavlov. Cond. lever latency0.20.20.30.5-0.4
Pavlov. Cond. magazine entry latency0.30.30.40.5-0.6
Pavlov. Cond. change in total contacts0.10.10.10.3-0.2
Pavlov. Cond. index score0.00.00.0-0.0-0.0
Pavlov. Cond. latency score0.00.10.1-0.30.2
Pavlov. Cond. lever contacts0.00.00.0-0.00.1
Pavlov. Cond. magazine entry number0.50.70.8-0.90.8
Pavlov. Cond. intertrial magazine entries0.20.30.40.4-0.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.0-0.1
Pavlov. Cond. response bias0.40.40.50.7-0.6
Pavlov. Cond. lever latency4.15.66.6-2.62.1
Pavlov. Cond. magazine entry latency0.00.00.10.10.2
Pavlov. Cond. change in total contacts2.74.35.52.4-1.7
Pavlov. Cond. index score2.63.44.32.1-1.6
Pavlov. Cond. latency score1.92.63.31.8-1.4
Pavlov. Cond. lever contacts3.44.75.72.4-2.0
Pavlov. Cond. magazine entry number0.50.60.8-0.90.7
Pavlov. Cond. intertrial magazine entries0.50.81.1-1.10.7
Pavlov. Cond. lever-magazine prob. diff.2.12.83.61.9-1.4
Pavlov. Cond. response bias3.64.86.02.4-1.9
Time in closed arm before self-admin0.30.30.4-0.60.5
Time in closed arm after self-admin1.01.11.4-1.20.9
Time in open arm before self-admin0.10.10.1-0.20.4
Time in open arm after self-admin0.40.40.70.8-0.5
Bone: periosteal estimation1.94.04.92.2-1.7
Bone: periosteal perimeter2.44.25.02.2-1.8
Bone: post-yield work1.01.52.2-0.91.5
Progressive ratio test 1 active lever presses1.61.92.21.3-1.5
Progressive ratio test 1 breakpoint1.72.12.41.3-1.5
Progressive ratio test 1 inactive lever presses0.10.10.20.3-0.5
Progressive ratio test 2 active lever presses0.20.30.30.6-0.5
Progressive ratio test 2 breakpoint0.30.40.40.6-0.6
Progressive ratio test 2 inactive lever presses0.30.40.50.7-0.6
Incentive Sensitization - Responses0.10.10.10.3-0.3
Incentive Sensitization - Breakpoint0.00.00.00.1-0.1
Sum of active levers in priming session hrs 5-60.90.81.01.0-0.8
Progressive ratio4.57.09.0-2.33.0
Food seeking constrained by brief footshock0.00.00.00.10.1
Seeking ratio, punishment vs. effort3.34.85.72.0-2.4
Retroperitoneal fat weight0.93.84.7-1.72.2
Reaction time number correct0.20.30.60.8-0.2
Reaction time mean minus median0.51.21.7-0.91.3
Reaction time mean minus median AUC0.30.71.0-0.71.0
Reaction time num false alarms1.52.22.51.4-1.6
Reaction time num false alarms AUC1.62.42.81.4-1.7
Reaction time trials correct on left0.20.30.60.8-0.2
Reaction time trials on left0.20.40.80.9-0.2
Reaction time mean0.00.00.0-0.00.0
Reaction time mean AUC0.00.00.0-0.10.1
Median of all reaction times0.00.10.10.2-0.3
Reaction time omissions0.71.01.01.0-1.0
Reaction time false alarm rate1.01.31.90.9-1.4
Reaction time premature initiation rate0.10.20.3-0.6-0.1
Reaction time premature initiations0.00.10.1-0.30.0
Std. dev. reaction times0.10.10.20.4-0.2
Reaction time trials completed0.20.40.80.9-0.2
Reaction time trials AUC0.20.50.90.9-0.3
Run reversals in cocaine runway, females0.10.10.2-0.40.1
Run reversals in cocaine runway, males1.51.52.30.9-1.5
Latency to leave start box in cocaine runway0.30.40.6-0.80.3
Latency to leave start box in cocaine runway, F0.70.81.5-1.20.4
Latency to leave start box in cocaine runway, M0.20.20.30.6-0.3
Std. dev. time between licks in bursts0.30.40.50.7-0.6
Total sessions with >9 infusions0.10.20.30.5-0.2
Short access day 1 total inactive lever presses2.53.33.4-1.81.8
Short access day 10 total inactive lever presses1.12.63.0-1.51.7
Short access day 1 total infusions0.10.10.2-0.30.4
Short access day 10 total infusions0.10.20.2-0.30.5
Short access total infusions0.00.00.00.20.1
Short access day 1 locomotion0.60.80.9-1.00.8
Short access day 10 total locomotion0.00.00.0-0.10.0
Short access total locomotion0.00.00.0-0.20.1
One hour access (0.3 mA shock)0.00.00.00.0-0.2
Compulsive drug intake1.61.91.9-1.41.4
One hour access (shock baseline)0.50.70.70.9-0.8
Social response proportion1.01.11.51.2-0.9
Social responses5.16.66.82.5-2.6
Social time0.50.70.90.7-1.0
Soleus weight0.00.00.0-0.0-0.2
Bone: stiffness2.13.44.22.0-1.6
Tibialis anterior weight1.34.55.11.9-2.3
Time to tail flick, vehicle, before self-admin2.32.43.0-1.31.7
Time to tail flick, vehicle, after self-admin0.71.01.2-0.81.1
Time to tail flick, test, before self-admin0.80.91.01.0-0.8
Time to tail flick, test, after self-admin0.50.50.5-0.70.7
Delta time to tail flick, vehicle, before/after SA2.92.73.11.8-1.5
Delta time to tail flick, test, before/after SA1.11.11.1-1.01.1
Tibia length4.813.114.13.8-3.5
Ambulatory time before self-admin2.53.84.52.1-1.7
Ambulatory time after self-admin2.93.44.12.0-1.6
Bone: tissue strength0.10.10.10.4-0.1
Total heroin consumption3.44.04.31.9-2.1
Bone: trabecular number1.11.82.41.1-1.5
Bone: trabecular spacing0.00.00.1-0.20.2
Bone: trabecular thickness0.60.71.00.7-1.0
Bone: trabecular tissue density1.92.93.11.8-1.6
Water consumed over 24 hours0.00.10.1-0.10.3
Number of responses in last shaping day0.00.00.10.1-0.3