LOC134485908

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC134485908	0.03	0.02	3.0e-03	0.01	0	0	0	4.9e-02	7.6e-02	1.4e-01	7.3e-02
2	Brain	mRNA stability	LOC134485908	0.03	0.02	4.2e-03	0.02	0.02	0.02	0.01	4.0e-03	5.4e-03	7.4e-03	1.3e-02
3	Liver	mRNA stability	LOC134485908	0.04	0.03	4.1e-03	0	0.01	0.01	0.01	7.3e-02	1.1e-02	2.0e-02	2.3e-02
4	Brain	gene expression	LOC134485908	0.03	0.03	8.0e-03	0	0.02	0	0.01	1.4e-01	3.0e-03	1.5e-01	4.9e-02
5	NAcc	gene expression	LOC134485908	0.04	0.02	1.5e-06	0.04	0.04	0.04	0.04	8.5e-07	1.5e-06	2.3e-06	2.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.8	3.1	5.5	1.6	-1.7	-2.3	1.0	1.8
Area under the delay curve	0.7	0.8	2.0	0.8	-0.2	-0.6	1.4	0.9
BMI with tail	0.5	1.8	4.8	-1.9	2.2	0.3	-0.8	-0.2
BMI without tail	0.1	0.2	0.5	0.2	-0.0	-0.7	0.6	0.5
Body weight	0.3	1.5	3.0	-1.7	1.7	0.3	-0.1	1.3
Weight adjusted by age	0.1	0.1	0.6	-0.2	0.1	0.1	-0.8	-0.3
Bone surface	0.3	0.5	1.0	-1.0	0.8	-0.6	-0.3	0.8
Bone volume	0.2	0.4	1.0	-0.5	0.3	-1.0	-0.2	0.9
Breakpoint value in progressive ratio session	0.5	0.6	1.1	0.7	-1.0	-0.8	0.6	0.5
Number of licking bursts	0.2	0.2	0.6	-0.7	0.2	0.2	-0.3	0.8
Context. condit. distance diff. score	0.7	0.9	2.2	1.5	-1.1	-0.6	0.3	0.7
Locomotion velocity, session 1	2.6	2.8	5.7	-2.4	2.3	0.7	-1.6	-0.2
Locomotion distance, session 1	2.2	2.7	5.5	-2.2	2.4	1.2	-1.2	-0.6
Locomotion velocity, session 2	5.6	6.6	11.6	-3.4	3.1	1.8	-2.8	-0.5
Locomotion distance, session 2	4.5	6.2	10.3	-3.2	2.6	2.5	-2.5	-1.2
Locomotion velocity, session 3	0.9	1.0	2.0	-0.1	-0.3	1.3	-1.2	-1.4
Locomotion distance, session 3	0.4	0.5	1.1	0.1	-0.4	1.0	-0.5	-1.0
Stereotopy head waving bouts, day 3	0.8	0.9	1.2	-1.0	0.7	0.9	-1.1	-1.1
Stereotopy head waving duration, day 3	1.1	1.3	2.0	-1.3	1.0	0.9	-1.4	-1.1
Locomotion velocity, session 7	0.5	0.5	1.1	0.9	-0.4	-0.5	0.5	1.0
Locomotion distance, session 7	1.1	1.4	2.8	1.4	-0.7	-1.0	0.7	1.7
Stereotopy head waving bouts, day 7	1.0	1.1	1.7	-1.0	0.3	1.1	-1.3	-1.2
Stereotopy head waving duration, day 7	0.9	1.0	1.7	-0.7	0.1	1.1	-1.3	-1.3
Locomotion velocity, session 8	1.1	1.3	2.7	-1.6	1.6	0.9	-0.8	-0.3
Locomotion distance, session 8	1.5	2.2	3.5	-1.4	1.6	1.6	-1.9	-0.6
Degree of sensitization distance	2.4	2.4	6.2	1.2	-0.5	-1.7	1.1	2.5
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.5	-0.2	0.5	-0.5	-0.5
Conditioned locomotion	0.5	0.6	1.8	0.3	-0.5	0.7	-0.3	-1.4
Cocaine response after cond. corrected	0.1	0.1	0.4	0.5	-0.6	0.2	0.2	-0.2
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.4	-0.5	-0.0	0.3	-0.3
Cocaine response before conditioning	0.3	0.3	0.9	-0.4	0.7	-1.0	0.2	-0.0
Saline control response	0.8	1.0	2.4	-0.9	0.7	1.6	-0.4	-1.1
Bone: connectivity density	2.2	3.4	6.3	1.3	-1.3	-2.5	1.4	2.3
Bone: cortical apparent density	0.2	0.3	0.9	0.5	-0.5	-0.2	-0.9	-0.4
Bone: cortical area	1.1	1.7	4.2	-2.0	1.8	0.1	-1.0	-0.2
Bone: cortical porosity	0.2	0.2	0.6	-0.4	0.8	0.4	-0.1	-0.2
Bone: cortical porosity	0.3	0.3	1.1	-0.7	1.1	0.1	-0.1	0.1
Bone: cortical thickness	0.1	0.1	0.3	-0.6	0.4	-0.4	-0.1	0.2
Bone: cortical thickness	0.0	0.0	0.0	-0.2	0.1	-0.2	-0.1	0.2
Bone: cortical tissue density	0.2	0.3	0.9	0.5	-0.5	-0.1	-0.9	-0.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.4	0.3	0.6	0.2	0.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	0.6	-0.7	0.2	0.8	0.2
Condit. Reinf. active responses	1.1	1.4	2.7	-1.6	1.3	1.5	-0.5	-0.3
Condit. Reinf. inactive responses	3.0	3.7	6.8	-2.6	2.3	1.8	-1.5	-0.9
Incentive salience index mean	1.9	2.3	4.0	-2.0	1.8	1.6	-1.1	-0.6
Condit. Reinf. lever presses	5.2	7.3	11.7	-3.4	3.3	2.2	-2.4	-1.8
Condit. Reinf. active minus inactive responses	0.1	0.2	0.8	0.2	-0.2	0.1	0.9	0.3
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.8	1.2	-1.4	0.5	1.0	-0.3
Condit. Reinf. active responses	0.9	1.2	3.0	-1.6	1.7	0.6	-0.4	-0.2
Condit. Reinf. inactive responses	2.8	3.7	9.4	-2.7	3.1	0.5	-1.2	-0.2
Condit. Reinf. lever presses	1.8	2.5	4.3	-1.6	1.3	2.1	-1.0	-1.7
Condit. Reinf. lever reinforcers received	0.9	1.2	3.1	-1.6	1.8	0.5	-0.4	-0.2
Conditioned reinforcement - actives	0.9	1.6	4.3	0.7	0.1	-2.1	1.1	1.4
Conditioned reinforcement - inactives	0.3	0.4	0.7	-0.8	0.8	-0.1	-0.8	-0.3
Conditioned locomotion	1.0	1.2	2.1	-1.4	1.4	0.4	-1.2	-0.7
Patch foraging indifference point 0 sec	1.1	2.1	3.4	-1.5	1.7	1.1	-1.9	-0.7
Patch foraging indifference point AUC	0.2	0.3	0.9	-0.2	0.3	0.8	-0.0	-0.9
Delay disc. indifference point, 0s delay	1.9	2.0	3.9	0.8	-0.9	-2.0	1.2	1.8
Delay disc. indifference point, 16s delay	0.3	0.4	1.2	0.4	0.0	-0.1	1.1	0.6
Delay disc. indifference point, 2s delay	0.3	0.4	0.7	0.4	0.1	-0.6	0.9	0.8
Delay disc. indifference point, 24s delay	2.7	3.0	4.8	2.1	-1.9	-1.1	2.2	1.1
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	0.1	0.2	-0.6	0.5	0.7
Delay disc. indifference point, 8s delay	1.7	2.0	4.4	1.5	-0.8	-1.1	2.1	1.2
Indifference point function ln k	0.2	0.3	1.2	-0.1	-0.0	-0.5	-0.2	1.1
Indifference point function log k	0.2	0.3	1.2	-0.1	-0.0	-0.5	-0.2	1.1
Patch foraging total patch changes 0 sec	0.7	1.3	2.4	-1.2	1.5	0.7	-1.5	-0.4
Patch foraging total patch changes 12 sec	0.3	0.4	0.5	-0.5	0.6	0.6	-0.7	-0.7
Patch foraging total patch changes 18 sec	0.9	1.4	1.7	-1.2	1.3	1.3	-0.9	-1.2
Patch foraging total patch changes 24 sec	0.9	1.5	2.1	-1.3	1.3	1.5	-1.0	-1.0
Patch foraging total patch changes 6 sec	3.0	4.6	5.8	-2.1	2.4	1.7	-2.4	-2.0
Patch foraging time to switch 0 sec	0.1	0.2	0.4	0.6	-0.6	0.0	0.3	-0.2
Patch foraging water rate 0 sec	0.1	0.2	0.6	-0.2	0.1	-0.8	-0.1	0.7
Patch foraging water rate 12 sec	0.1	0.2	0.6	-0.2	0.5	-0.8	-0.3	0.3
Patch foraging water rate 18 sec	0.1	0.1	0.3	-0.2	0.0	-0.2	-0.3	0.6
Patch foraging water rate 24 sec	0.3	0.4	1.2	-0.4	0.7	-0.1	-1.1	-0.0
Patch foraging water rate 6 sec	0.4	0.6	2.1	0.3	-0.2	-0.8	0.2	1.5
Seeking ratio, delayed vs. immediate footshock	1.5	1.8	2.4	1.2	-1.3	-1.2	1.6	1.4
Distance traveled before self-admin	0.2	0.2	0.7	0.2	0.5	0.8	0.4	0.1
Distance traveled after self-admin	3.3	4.1	6.8	-1.4	2.1	2.6	-1.7	-2.1
Extensor digitorum longus weight	2.6	10.3	14.8	-3.7	2.7	3.9	-2.9	-2.7
Bone: elastic displacement	1.7	1.9	2.8	1.6	-1.7	1.4	0.4	-1.4
Bone: elastic work	1.3	1.7	3.5	-0.9	0.4	1.7	-1.1	-1.9
Bone: endosteal estimation	1.5	3.3	7.2	-2.7	2.6	0.9	-1.2	-0.4
Bone: endosteal perimeter	0.3	0.6	1.7	-1.3	1.1	-0.0	-0.2	0.1
Epididymis fat weight	0.1	0.2	0.7	-0.2	-0.1	0.1	0.8	0.7
Delta time in closed arm before/after self-admin	2.4	2.3	3.1	1.4	-0.9	-1.7	1.5	1.7
Delta time in open arm before/after self-admin	1.0	1.0	3.1	-0.3	0.1	1.8	-0.6	-1.2
Diff in mean of infusions in LGA sessions	0.4	0.4	1.0	-0.3	-0.5	1.0	-0.2	-0.9
Delay discount exponential model param	0.8	0.9	2.1	-0.9	0.3	0.7	-1.5	-0.9
Extinction: sum of active levers before priming	1.2	1.3	2.5	1.3	-1.4	-0.3	1.6	0.4
Active lever presses in extinction session 6	0.5	0.5	0.8	0.7	-0.7	-0.6	0.9	0.5
Bone: final force	1.1	1.8	3.6	-1.9	1.7	0.5	-1.4	-0.3
Bone: final moment	1.7	2.7	5.2	-2.3	2.0	0.9	-1.7	-0.7
Food consumed during 24 hour testing period	0.4	0.5	0.9	-0.7	0.4	0.9	-1.0	-0.0
Glucose	0.3	0.4	0.9	0.9	-0.9	-0.3	0.5	0.2
Heart weight	2.1	3.2	7.9	0.8	-0.2	-2.3	1.4	2.8
Delay discount hyperbolic model param	1.0	1.1	2.4	-1.0	0.4	0.8	-1.5	-1.1
Intermittent access intake day 1-15 change	0.5	1.1	2.8	-0.7	0.8	1.7	-0.2	-1.3
Intermittent access intake escalation	0.5	1.1	2.8	-0.6	0.8	1.7	0.0	-1.2
Intermittent access intake escalation 2	1.7	1.9	6.0	-0.6	0.4	2.4	-0.3	-1.7
Intermitt. access day 1 inactive lever presses	0.2	0.8	1.5	-1.1	1.2	0.1	-0.8	-0.9
Intermitt. access day 15 inactive lever presses	0.3	0.6	2.2	0.6	-1.5	-0.3	0.8	-0.0
Intermitt. access escalation Index	2.0	2.9	4.0	1.8	-1.6	-1.5	2.0	1.5
Intermittent access day 1 total infusions	0.2	0.3	0.6	-0.6	0.8	-0.8	-0.1	0.4
Intermittent access day 15 total infusions	0.2	0.2	0.5	-0.2	0.7	-0.2	0.7	0.2
Intermittent access terminal intake (last 3 days)	0.5	0.7	1.6	-0.9	1.3	0.7	-0.3	-0.6
Intermittent access total infusions	0.2	0.3	0.7	-0.2	0.8	-0.6	0.3	0.4
Intermittent access day 1 locomotion	0.4	0.5	1.4	-0.7	1.2	-0.6	-0.5	-0.2
Intermittent access day 15 total locomotion	0.7	1.2	2.5	-1.3	1.6	0.5	-1.0	-0.8
Intermittent access total locomotion	1.3	1.5	2.5	-1.6	1.5	0.5	-1.4	-0.9
Intermittent access standard deviation	0.1	0.1	0.3	-0.2	0.3	0.5	0.3	-0.4
Left kidney weight	0.1	0.4	1.0	-0.8	0.3	1.0	-0.6	0.3
Right kidney weight	0.2	0.7	2.4	-0.5	-0.1	1.6	-0.8	-0.7
Cocaine induced anxiety	0.1	0.2	0.6	0.4	-0.1	0.4	0.8	-0.4
Post-drug Anxiety	0.9	1.0	1.8	-0.5	0.8	1.1	-1.0	-1.3
Baseline Anxiety	2.2	2.6	7.3	-1.3	1.3	0.9	-2.7	-1.3
Tail length	0.2	0.8	1.2	0.5	-1.0	-0.5	1.1	1.1
Length with tail	0.1	0.5	1.0	-1.0	0.2	0.8	0.1	1.0
Length without tail	0.9	2.8	6.3	-2.5	1.9	1.7	-1.2	0.4
Times rat made contact with spout	0.3	0.4	1.0	-0.2	0.3	0.9	-1.0	-0.1
Lifetime Intake	0.5	0.6	1.3	-0.1	0.9	-1.1	0.6	0.8
Liver weight, left	0.7	1.2	2.6	-1.4	1.6	0.9	-0.8	-0.4
Liver weight, right	2.0	3.5	5.2	-2.0	2.1	1.2	-2.3	-1.7
Locomotor activity	2.4	3.8	6.5	-2.5	2.5	1.8	-0.8	-1.5
Locomotor testing distance	0.9	1.6	3.1	-1.7	1.6	1.2	0.0	-0.7
Locomotor testing rearing	0.3	0.7	1.7	-1.1	1.3	0.7	-0.1	-0.3
Locomotion in novel chamber	0.9	1.2	1.8	-0.9	1.0	0.9	-1.1	-1.4
Locomotion in novel chamber post-restriction	0.3	0.6	1.6	0.3	0.0	-1.3	0.5	1.0
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	0.4	0.1	0.4	0.9	-0.1
Change in fecal boli incidents, locomotor task	0.4	0.4	0.8	-0.5	0.9	-0.2	-0.7	-0.4
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	-0.3	0.6	0.0	-0.5	-0.4
Bouts of movement, locomotor time 1	2.0	2.3	4.9	0.7	-0.5	-2.2	1.3	2.0
Total resting periods, locomotor time 1	2.2	2.4	5.5	0.7	-0.5	-2.4	1.3	2.1
Rest time, locomotor task time 1	1.5	1.9	4.6	0.7	-0.2	-2.1	0.9	1.9
Distance moved, locomotor task time 1	0.5	0.7	1.4	0.7	-1.2	1.1	0.3	-0.5
Vertical activity count, locomotor time 1	0.7	1.6	4.9	-0.1	-0.3	2.2	-0.8	-1.6
Time >=10cm from walls, locomotor time 2	0.2	0.3	1.0	0.2	-0.0	-0.6	0.4	1.0
Bouts of movement, locomotor time 2	3.3	5.3	11.2	1.6	-1.6	-3.4	2.2	2.3
Total resting periods, locomotor time 2	2.3	4.0	9.1	1.3	-1.3	-3.0	1.9	2.0
Rest time, locomotor task time 2	0.3	0.4	1.4	-0.7	1.2	-0.2	-0.5	-0.0
Distance moved, locomotor task time 2	0.9	1.0	2.5	1.2	-1.6	-0.2	1.0	0.6
Vertical activity count, locomotor time 2	0.4	0.5	1.6	0.1	-0.1	1.2	-0.5	-0.8
Light reinforcement 1	0.1	0.2	0.3	-0.5	0.0	0.5	-0.1	-0.5
Light reinforcement 2	1.5	2.3	4.8	-2.2	1.7	1.2	-1.5	-0.3
Bone: marrow area	1.7	3.6	7.6	-2.8	2.7	1.0	-1.4	-0.5
Bone: maximum diameter	2.3	4.2	8.4	-2.9	2.7	0.9	-2.0	-0.9
Bone: maximum force	0.9	1.5	3.1	-1.8	1.5	0.6	-1.2	-0.5
Bone: maximum moment	1.4	2.4	4.6	-2.1	1.8	1.0	-1.5	-0.9
Mean time between licks in bursts	0.4	1.0	1.6	-1.2	1.1	1.3	-0.8	-0.4
Mean num. licks in bursts	0.2	0.3	0.8	0.9	-0.3	0.1	-0.0	-0.6
Cd content in liver	0.2	0.2	0.7	0.0	-0.2	-0.5	0.3	0.8
Co content in liver	0.3	0.3	0.7	0.8	-0.6	-0.2	0.8	0.0
Cu content in liver	0.1	0.2	0.3	-0.3	0.4	0.6	-0.1	-0.4
Fe content in liver	1.2	1.5	2.6	1.6	-1.5	-0.5	1.5	-0.4
K content in liver	1.9	1.8	4.3	-1.9	2.1	0.2	-0.9	0.4
Mg content in liver	1.2	1.2	2.3	-1.5	1.5	-0.0	-0.4	1.1
Mn content in liver	1.1	1.2	2.6	0.6	-0.8	-1.6	1.2	1.1
Na content in liver	1.8	1.9	4.6	-1.8	2.1	0.6	-1.1	-0.2
Rb content in liver	0.3	0.4	0.9	-0.4	0.4	0.8	-0.0	-1.0
Se content in liver	0.4	0.4	1.0	0.6	-0.1	-1.0	0.6	0.7
Sr content in liver	2.5	2.2	2.9	1.4	-1.5	-1.7	1.7	1.1
Zn content in liver	1.5	1.6	6.0	-0.0	0.2	-1.3	0.6	2.5
Bone: minimum diameter	0.7	1.3	3.0	-1.7	1.7	-0.5	0.0	0.8
Time in familiar zone, hab. session 1	3.1	3.0	5.0	-1.5	1.3	1.7	-1.8	-2.2
Time in novel zone, hab. session 1	3.8	3.8	4.8	1.8	-1.7	-2.1	1.9	2.2
Total zone transitions, hab. session 1	1.4	1.9	3.8	-2.0	1.9	1.0	-1.1	-0.3
Total locomotion distance, hab. session 1	0.2	0.2	1.0	-1.0	0.1	0.0	-0.3	0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.6	-0.8	-0.1	0.1	-0.1	-0.2
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.2	0.2	0.2	-0.6	-0.7
Time in novel zone, hab. session 2	1.0	1.0	1.4	1.2	-1.2	-0.4	1.2	1.0
Total zone transitions, hab. session 2	3.6	4.5	8.4	-2.9	2.9	1.2	-2.1	-0.4
Total locomotion distance, hab. session 2	0.7	0.9	2.2	-1.5	1.0	0.5	-0.9	0.2
Locomotion velocity, hab. session 2	0.9	1.2	3.3	-1.8	1.3	0.4	-1.0	0.3
Novel to familiar place preference ratio	0.1	0.1	0.2	0.2	0.0	-0.4	-0.3	0.4
Novelty place preference	0.1	0.1	0.2	0.2	-0.1	-0.4	-0.4	0.3
Time in novel zone, NPP test	0.1	0.1	0.2	0.3	-0.1	-0.3	-0.4	0.2
Total zone transitions, NPP test	1.1	1.6	3.3	-1.8	1.8	0.7	-0.9	-0.4
Total locomotion distance, NPP test	0.6	0.8	2.1	-1.5	1.2	-0.0	-0.5	0.4
Locomotion velocity, NPP test	0.5	0.8	2.1	-1.4	1.2	0.1	-0.5	0.2
Intraocular pressure	1.2	1.8	3.1	1.0	-1.0	-1.3	1.4	1.8
Delta distance traveled before/after self-admin	3.8	4.0	5.9	-1.6	1.6	2.1	-2.1	-2.4
Delta ambulatory time before/after self-admin	2.1	2.6	4.2	-1.2	1.1	1.8	-1.7	-2.1
Parametrial fat weight	0.9	2.0	4.6	-1.7	1.0	2.1	-0.5	-1.2
Pavlov. Cond. lever latency	6.5	8.2	13.0	3.6	-3.4	-2.3	2.7	1.9
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	-0.7	0.4	0.2	-0.3	-0.0
Pavlov. Cond. change in total contacts	1.2	1.3	3.1	-1.8	1.4	0.4	-0.9	0.4
Pavlov. Cond. index score	2.5	3.2	5.3	-2.3	2.0	1.4	-2.0	-0.8
Pavlov. Cond. latency score	3.1	4.0	6.9	-2.6	2.4	1.4	-2.1	-0.9
Pavlov. Cond. lever contacts	4.9	5.9	10.5	-3.2	3.0	1.8	-2.4	-1.1
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	0.9	-0.5	-0.4	1.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.0	0.9	-0.9	-0.2	1.0	0.8
Pavlov. Cond. lever-magazine prob. diff.	2.3	2.9	4.9	-2.2	1.9	1.3	-1.8	-0.8
Pavlov. Cond. response bias	2.0	2.5	4.5	-2.1	1.7	1.4	-1.7	-0.4
Pavlov. Cond. lever latency	2.6	3.5	6.5	2.5	-2.4	-1.6	1.4	0.8
Pavlov. Cond. magazine entry latency	4.0	4.9	7.3	-2.1	1.9	2.7	-2.2	-1.9
Pavlov. Cond. change in total contacts	1.5	2.5	5.2	-2.2	2.3	1.2	-0.9	-0.1
Pavlov. Cond. index score	3.5	4.7	6.7	-2.6	2.5	2.4	-1.8	-1.3
Pavlov. Cond. latency score	3.2	4.2	6.4	-2.5	2.5	2.2	-1.7	-1.0
Pavlov. Cond. lever contacts	3.2	4.5	7.7	-2.8	2.6	1.8	-1.8	-1.0
Pavlov. Cond. magazine entry number	4.3	5.4	8.4	2.3	-2.2	-2.9	2.2	1.9
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.4	1.2	-0.7	-0.7	0.9	0.4
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.8	5.5	-2.3	2.2	2.2	-1.7	-1.1
Pavlov. Cond. response bias	4.0	5.5	8.7	-3.0	2.8	2.2	-2.0	-1.5
Time in closed arm before self-admin	0.7	0.9	1.9	-0.9	1.1	0.5	-1.4	-0.6
Time in closed arm after self-admin	0.7	0.7	1.4	0.7	0.1	-1.0	0.7	1.2
Time in open arm before self-admin	0.1	0.1	0.6	-0.8	-0.0	0.3	-0.1	-0.1
Time in open arm after self-admin	0.3	0.3	0.8	-0.1	-0.6	0.9	-0.2	-0.7
Bone: periosteal estimation	1.9	4.0	9.4	-3.1	2.8	0.7	-1.4	-0.5
Bone: periosteal perimeter	0.6	1.0	2.6	-1.6	1.5	-0.3	-0.4	0.2
Bone: post-yield work	0.1	0.2	0.4	-0.6	0.5	0.2	0.0	-0.0
Progressive ratio test 1 active lever presses	0.3	0.3	1.2	-0.3	0.3	-1.1	0.2	0.6
Progressive ratio test 1 breakpoint	0.2	0.3	0.7	-0.5	0.5	-0.9	-0.1	0.4
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.6	-0.8	0.3	-0.1	-0.3	-0.1
Progressive ratio test 2 active lever presses	0.4	0.4	0.9	-0.4	0.8	-1.0	0.2	0.6
Progressive ratio test 2 breakpoint	0.4	0.4	0.8	-0.5	0.9	-0.9	0.1	0.5
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.6	-0.3	0.2	-0.8	0.6	0.7
Incentive Sensitization - Responses	0.3	0.4	1.0	-0.9	1.0	0.2	-0.3	-0.4
Incentive Sensitization - Breakpoint	0.2	0.3	0.8	-0.8	0.9	0.2	-0.2	-0.3
Sum of active levers in priming session hrs 5-6	0.4	0.3	0.7	-0.2	0.5	0.8	0.0	-0.9
Progressive ratio	3.3	5.1	6.8	2.1	-1.6	-2.6	2.4	2.5
Food seeking constrained by brief footshock	1.8	2.2	4.1	0.9	-0.6	-1.7	2.0	1.7
Seeking ratio, punishment vs. effort	0.6	0.8	1.1	-0.9	0.8	1.0	-0.8	-0.9
Retroperitoneal fat weight	0.1	0.6	1.7	-0.8	0.1	1.3	0.7	0.2
Reaction time number correct	0.0	0.1	0.2	-0.2	0.1	-0.1	-0.4	0.5
Reaction time mean minus median	1.2	3.1	9.5	-0.3	0.2	3.1	-0.4	-2.4
Reaction time mean minus median AUC	0.5	1.2	4.5	0.0	-0.1	2.1	0.1	-1.3
Reaction time num false alarms	3.1	4.4	5.9	1.9	-2.0	-2.4	2.1	2.1
Reaction time num false alarms AUC	2.2	3.5	5.0	1.7	-1.8	-2.2	1.8	1.7
Reaction time trials correct on left	0.0	0.1	0.2	-0.2	0.1	-0.1	-0.4	0.5
Reaction time trials on left	0.0	0.1	0.2	-0.1	0.0	-0.1	-0.3	0.5
Reaction time mean	0.8	1.3	2.6	0.9	-1.2	1.6	0.5	-1.2
Reaction time mean AUC	0.7	1.2	3.2	0.5	-0.9	1.8	0.4	-1.3
Median of all reaction times	0.9	1.2	2.8	1.3	-1.7	0.7	1.0	-0.4
Reaction time omissions	1.2	1.8	4.7	1.2	-1.6	0.6	2.2	-0.0
Reaction time false alarm rate	3.0	4.1	5.4	1.9	-2.0	-2.3	2.3	1.5
Reaction time premature initiation rate	4.7	6.5	8.6	2.9	-2.5	-2.7	2.6	2.0
Reaction time premature initiations	2.6	4.6	5.6	2.4	-2.1	-2.3	2.0	2.0
Std. dev. reaction times	0.7	1.3	4.0	0.2	-0.1	2.0	0.3	-1.5
Reaction time trials completed	0.0	0.1	0.2	-0.1	0.0	-0.1	-0.3	0.5
Reaction time trials AUC	0.1	0.1	0.4	-0.1	0.0	-0.2	-0.3	0.7
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.1	0.2	0.0	-0.3	-0.3
Run reversals in cocaine runway, males	1.1	1.1	1.9	-1.1	1.4	1.3	-0.7	-0.7
Latency to leave start box in cocaine runway	0.6	0.7	1.3	0.9	-1.1	0.2	1.1	-0.1
Latency to leave start box in cocaine runway, F	0.2	0.3	0.7	0.6	-0.9	0.1	0.4	-0.1
Latency to leave start box in cocaine runway, M	0.4	0.3	1.1	0.5	-0.4	0.2	1.1	-0.4
Std. dev. time between licks in bursts	0.4	0.5	1.1	-1.0	1.0	-0.2	0.4	0.5
Total sessions with >9 infusions	2.0	2.5	4.5	0.4	0.5	-2.1	1.8	2.0
Short access day 1 total inactive lever presses	1.3	1.7	3.3	1.0	-0.4	-1.8	1.5	1.4
Short access day 10 total inactive lever presses	0.5	1.1	1.6	-1.0	0.8	1.3	-0.9	-1.2
Short access day 1 total infusions	1.4	1.9	3.6	-0.2	1.2	-1.9	1.2	1.7
Short access day 10 total infusions	0.5	0.7	1.5	-0.1	0.6	-1.2	0.6	1.0
Short access total infusions	1.0	1.3	2.7	0.2	0.7	-1.7	1.2	1.4
Short access day 1 locomotion	1.0	1.3	4.5	-1.1	2.1	-0.6	-0.1	0.5
Short access day 10 total locomotion	0.3	0.6	1.2	-1.1	1.0	-0.1	-0.8	-0.2
Short access total locomotion	0.8	1.0	2.0	-0.4	1.3	-1.4	0.4	0.9
One hour access (0.3 mA shock)	0.6	0.6	1.0	-1.0	0.5	0.8	-0.7	-0.9
Compulsive drug intake	0.9	1.0	1.6	-0.9	0.0	1.2	-1.3	-1.1
One hour access (shock baseline)	0.1	0.2	0.6	-0.3	0.8	-0.5	0.2	0.3
Social response proportion	0.6	0.6	1.2	1.1	-0.5	-0.1	0.9	-0.9
Social responses	0.3	0.4	1.1	-0.5	0.8	0.0	-0.0	-1.1
Social time	1.6	2.2	4.2	2.1	-1.6	-0.3	1.7	-1.0
Soleus weight	0.9	2.8	6.4	-1.9	1.4	1.4	-2.5	-0.4
Bone: stiffness	0.7	1.1	2.5	-1.4	1.6	-0.1	-0.8	0.3
Tibialis anterior weight	5.6	18.9	30.2	-5.5	4.8	3.8	-4.4	-2.7
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.1	-0.2	0.4	0.4	0.1
Time to tail flick, vehicle, after self-admin	2.6	3.5	4.8	1.6	-2.2	-1.6	1.9	1.9
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.1	0.3	-0.5	0.7	0.7
Time to tail flick, test, after self-admin	0.5	0.5	0.8	0.9	-0.6	-0.6	0.6	0.8
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	2.2	0.9	-1.1	-1.5	0.6	1.1
Delta time to tail flick, test, before/after SA	0.4	0.4	0.9	0.8	-0.9	-0.5	0.5	0.3
Tibia length	1.5	4.1	8.2	-2.9	2.7	0.9	-2.0	0.1
Ambulatory time before self-admin	0.3	0.5	1.4	-0.2	0.9	1.2	-0.0	-0.3
Ambulatory time after self-admin	4.2	4.9	8.9	-1.3	2.1	3.0	-1.9	-2.5
Bone: tissue strength	1.2	1.2	2.0	-1.1	0.7	1.4	-0.8	-1.3
Total heroin consumption	0.4	0.4	1.1	0.5	-0.0	-1.0	0.5	0.8
Bone: trabecular number	1.9	3.1	6.2	1.5	-1.6	-2.5	1.0	1.9
Bone: trabecular spacing	0.0	0.0	0.1	0.1	0.1	0.0	0.4	0.2
Bone: trabecular thickness	0.2	0.3	0.6	-0.5	0.4	-0.7	-0.6	0.3
Bone: trabecular tissue density	1.0	1.4	2.6	-0.8	0.9	1.3	-1.2	-1.6
Water consumed over 24 hours	1.8	2.4	4.6	-1.6	1.5	1.6	-2.1	-0.1
Number of responses in last shaping day	1.4	1.6	3.9	-1.5	2.0	-0.8	-0.5	0.8