Hub : Genes

LOC134485824

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr2_30467590_30469768	0.03	0.02	9.0e-05	0.03	0.01	0.03	0.03	2.2e-05	2.0e-03	1.6e-05	2.1e-05
2	PL	intron excision ratio	chr2_30467590_30478990	0.02	0.01	4.4e-03	0.03	0.02	0.02	0.02	2.5e-04	6.0e-03	3.0e-03	1.9e-03
3	NAcc	intron excision ratio	chr2_30467590_30478990	0.07	0.04	1.4e-12	0.08	0.06	0.06	0.07	1.0e-11	8.2e-10	3.8e-10	4.8e-11
4	Liver	gene expression	LOC134485824	0.06	0.03	1.4e-03	0.01	0.01	0.01	0.01	3.7e-02	9.7e-03	6.3e-02	5.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.2	0.3	0.5	-0.4	-0.3	-0.5
Area under the delay curve	0.7	1.1	2.4	-1.2	1.5	0.9	0.1
BMI with tail	1.4	4.9	5.8	-2.4	2.3	2.0	2.0
BMI without tail	0.9	4.6	6.5	-2.5	1.8	2.1	2.1
Body weight	2.0	8.6	13.1	-3.6	3.3	3.0	1.1
Weight adjusted by age	0.5	1.5	5.6	0.2	-0.2	-0.4	2.4
Bone surface	0.1	0.1	0.3	-0.2	0.6	0.2	-0.3
Bone volume	0.2	0.4	0.5	0.7	-0.6	-0.4	-0.7
Breakpoint value in progressive ratio session	0.1	0.1	0.3	0.1	0.3	-0.2	-0.5
Number of licking bursts	0.1	0.3	0.7	-0.8	-0.3	0.0	0.5
Context. condit. distance diff. score	0.9	1.1	1.8	0.9	-1.4	-1.2	0.6
Locomotion velocity, session 1	0.2	0.3	1.0	-0.1	-1.0	-0.3	-0.2
Locomotion distance, session 1	0.4	0.5	1.2	0.4	-1.1	-0.7	-0.4
Locomotion velocity, session 2	0.3	0.3	1.0	-0.2	-1.0	0.4	-0.4
Locomotion distance, session 2	1.0	1.4	3.0	0.7	-1.7	-1.2	-0.8
Locomotion velocity, session 3	0.4	0.5	1.3	-0.5	-0.6	-0.4	1.1
Locomotion distance, session 3	0.2	0.2	0.4	-0.0	-0.5	-0.5	0.6
Stereotopy head waving bouts, day 3	0.5	0.6	1.1	0.5	-0.4	-1.0	-1.1
Stereotopy head waving duration, day 3	0.4	0.5	1.3	-0.1	0.8	0.1	-1.1
Locomotion velocity, session 7	1.1	1.2	2.3	0.6	-1.3	-0.8	1.5
Locomotion distance, session 7	0.1	0.2	0.3	-0.3	-0.5	0.3	0.6
Stereotopy head waving bouts, day 7	0.7	0.8	2.0	0.2	-0.8	-1.4	0.8
Stereotopy head waving duration, day 7	0.3	0.3	0.8	-0.0	-0.1	-0.7	0.9
Locomotion velocity, session 8	2.6	3.1	7.2	1.5	-2.7	-1.7	-0.3
Locomotion distance, session 8	0.9	1.4	3.1	0.4	-1.8	-1.1	1.0
Degree of sensitization distance	0.1	0.2	0.4	0.2	-0.4	0.2	-0.6
Degree of sensitization stereotypy	0.9	1.0	2.1	0.2	-0.7	-1.2	1.4
Conditioned locomotion	0.1	0.1	0.3	0.2	0.6	-0.3	-0.1
Cocaine response after cond. corrected	0.3	0.5	0.8	-0.9	0.4	0.9	0.5
Cocaine response after cond. not corrected	0.5	0.7	1.1	-1.0	0.3	1.0	0.8
Cocaine response before conditioning	0.2	0.2	0.4	0.2	-0.5	-0.2	0.6
Saline control response	0.3	0.4	0.9	-0.3	0.5	0.6	0.9
Bone: connectivity density	0.1	0.2	0.6	-0.3	0.7	0.1	-0.3
Bone: cortical apparent density	1.6	2.6	4.3	1.5	-1.8	-2.1	0.7
Bone: cortical area	1.7	2.8	6.6	2.6	-0.6	-1.8	-1.1
Bone: cortical porosity	0.1	0.1	0.1	-0.4	0.3	-0.1	0.0
Bone: cortical porosity	0.2	0.2	0.5	0.3	-0.3	-0.7	-0.3
Bone: cortical thickness	2.6	4.3	8.1	2.8	-1.3	-2.7	-0.5
Bone: cortical thickness	0.2	0.2	0.7	0.3	-0.0	0.2	0.8
Bone: cortical tissue density	1.4	2.3	3.9	1.4	-1.7	-2.0	0.6
Condit. Reinf. active minus inactive responses	0.9	1.0	3.5	-0.4	-0.6	-0.2	1.9
Condit. Reinf. active-inactive response ratio	0.8	0.9	3.3	-0.0	-0.4	-0.4	1.8
Condit. Reinf. active responses	0.9	1.1	3.6	-0.8	-0.6	0.2	1.9
Condit. Reinf. inactive responses	0.2	0.3	0.5	-0.7	-0.2	0.7	0.4
Incentive salience index mean	0.9	1.2	2.9	-1.2	-0.1	0.7	1.7
Condit. Reinf. lever presses	0.3	0.5	1.0	-1.0	0.1	0.7	0.6
Condit. Reinf. active minus inactive responses	0.6	0.9	1.6	0.6	-1.3	-0.5	1.1
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.2	-0.1	-0.4	-0.1	0.4
Condit. Reinf. active responses	0.8	1.2	2.0	0.7	-1.4	-0.8	1.3
Condit. Reinf. inactive responses	0.2	0.4	1.2	-0.4	0.0	0.3	1.1
Condit. Reinf. lever presses	0.3	0.5	1.1	0.5	-1.1	-0.3	0.7
Condit. Reinf. lever reinforcers received	0.7	0.9	1.6	0.5	-1.2	-0.7	1.3
Conditioned reinforcement - actives	0.2	0.7	2.0	-0.6	1.4	0.8	0.1
Conditioned reinforcement - inactives	0.1	0.3	0.6	0.8	-0.4	-0.6	-0.3
Conditioned locomotion	0.2	0.3	0.5	0.5	0.5	-0.7	-0.5
Patch foraging indifference point 0 sec	0.7	2.0	3.8	-1.6	1.0	2.0	0.8
Patch foraging indifference point AUC	0.4	1.0	1.4	-1.0	1.2	0.9	-0.9
Delay disc. indifference point, 0s delay	0.7	0.8	1.7	0.7	-1.3	-0.5	0.8
Delay disc. indifference point, 16s delay	0.7	1.0	3.2	-0.7	1.8	0.3	-0.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	-0.6	0.4	0.1	0.6
Delay disc. indifference point, 24s delay	2.0	3.1	4.6	-2.1	1.7	2.1	0.7
Delay disc. indifference point, 4s delay	0.1	0.2	0.4	-0.2	-0.4	0.6	-0.1
Delay disc. indifference point, 8s delay	1.6	2.7	4.3	-1.9	2.1	1.6	0.5
Indifference point function ln k	0.0	0.1	0.5	0.2	-0.2	-0.0	0.7
Indifference point function log k	0.0	0.1	0.5	0.2	-0.2	-0.0	0.7
Patch foraging total patch changes 0 sec	0.7	2.2	4.1	-1.7	1.1	2.0	0.8
Patch foraging total patch changes 12 sec	1.2	1.6	2.5	-1.6	1.3	1.4	0.6
Patch foraging total patch changes 18 sec	0.2	0.5	0.7	-0.9	0.5	0.8	0.5
Patch foraging total patch changes 24 sec	0.5	1.7	2.6	-1.4	1.6	1.4	0.6
Patch foraging total patch changes 6 sec	1.6	2.7	4.6	-2.0	1.4	2.1	0.4
Patch foraging time to switch 0 sec	0.1	0.4	1.1	0.3	-0.5	-0.5	1.1
Patch foraging water rate 0 sec	0.1	0.4	0.7	-0.6	0.6	0.8	-0.4
Patch foraging water rate 12 sec	0.2	0.9	1.7	0.5	-0.7	-1.3	1.0
Patch foraging water rate 18 sec	0.2	0.4	1.3	-0.4	0.5	-0.0	1.1
Patch foraging water rate 24 sec	0.9	1.3	1.8	-1.3	1.3	1.3	0.5
Patch foraging water rate 6 sec	0.8	1.2	1.7	1.2	-0.8	-0.9	-1.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.1	-1.1	0.3	0.6	0.2
Distance traveled before self-admin	0.2	0.5	0.9	-0.9	1.0	0.1	0.2
Distance traveled after self-admin	1.4	2.5	4.1	-2.0	1.3	1.8	1.0
Extensor digitorum longus weight	0.1	0.2	0.5	-0.2	0.6	0.1	-0.7
Bone: elastic displacement	1.6	2.0	3.5	1.2	-0.6	-1.6	-1.9
Bone: elastic work	1.3	1.7	4.6	1.0	-0.0	-1.1	-2.2
Bone: endosteal estimation	0.2	0.4	1.1	-0.5	0.5	1.0	-0.2
Bone: endosteal perimeter	0.0	0.1	0.2	0.3	0.1	0.4	0.0
Epididymis fat weight	1.2	5.8	9.5	-3.1	2.3	2.1	2.0
Delta time in closed arm before/after self-admin	0.7	0.7	1.5	0.7	0.1	-1.2	-0.9
Delta time in open arm before/after self-admin	1.4	1.6	5.9	0.0	-0.7	0.0	2.4
Diff in mean of infusions in LGA sessions	0.7	1.2	2.9	1.1	-0.1	-0.9	-1.7
Delay discount exponential model param	1.0	1.3	2.5	1.3	-1.6	-1.0	-0.1
Extinction: sum of active levers before priming	0.4	0.6	2.4	-0.4	0.1	-0.1	1.5
Active lever presses in extinction session 6	0.8	0.8	2.3	-0.8	1.5	0.2	-0.4
Bone: final force	0.7	1.1	2.4	1.5	-0.7	-0.9	-0.7
Bone: final moment	0.5	0.8	1.8	1.3	-0.5	-0.9	-0.8
Food consumed during 24 hour testing period	0.9	1.7	6.0	-0.9	-0.1	0.2	2.5
Glucose	2.2	3.5	6.4	2.1	-2.5	-1.8	-0.2
Heart weight	1.8	2.9	4.5	-2.1	1.7	1.1	1.8
Delay discount hyperbolic model param	0.8	1.0	1.8	1.2	-1.3	-0.9	-0.1
Intermittent access intake day 1-15 change	0.2	1.0	1.4	1.1	-1.2	-1.1	-0.5
Intermittent access intake escalation	0.2	1.2	1.8	1.3	-1.3	-1.2	-0.5
Intermittent access intake escalation 2	0.5	0.8	1.5	1.2	-0.6	-0.9	-0.7
Intermitt. access day 1 inactive lever presses	0.3	3.6	5.4	2.3	-1.6	-2.3	-1.1
Intermitt. access day 15 inactive lever presses	0.6	3.0	4.8	1.5	-2.2	-2.2	-0.4
Intermitt. access escalation Index	0.3	1.1	2.5	1.2	-1.6	-0.6	-0.1
Intermittent access day 1 total infusions	1.2	3.7	6.4	-2.5	2.3	1.3	1.1
Intermittent access day 15 total infusions	0.1	0.2	0.7	-0.5	-0.0	-0.2	0.8
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	-0.6	0.4	-0.4	0.5
Intermittent access total infusions	0.8	0.9	1.8	-1.3	0.9	0.4	1.0
Intermittent access day 1 locomotion	0.8	1.5	3.5	-1.5	1.9	0.6	0.0
Intermittent access day 15 total locomotion	0.5	1.9	4.5	-1.6	2.1	0.5	0.5
Intermittent access total locomotion	0.9	1.0	2.7	-1.2	1.6	-0.0	0.1
Intermittent access standard deviation	0.1	0.4	0.5	-0.6	0.4	-0.7	0.7
Left kidney weight	3.1	24.6	36.0	-6.0	5.4	5.0	3.0
Right kidney weight	3.3	23.0	33.0	-5.7	5.2	4.9	2.8
Cocaine induced anxiety	0.1	0.3	0.9	-0.2	1.0	0.2	0.1
Post-drug Anxiety	1.1	1.3	3.0	-1.2	1.7	0.7	0.4
Baseline Anxiety	0.2	0.4	1.5	-1.2	0.3	0.2	-0.0
Tail length	0.6	3.4	5.6	-2.3	1.5	2.4	0.6
Length with tail	1.3	5.7	8.1	-2.8	2.6	2.9	-0.1
Length without tail	0.6	3.0	4.4	-1.9	2.0	2.1	-0.1
Times rat made contact with spout	3.0	3.4	8.3	-1.8	1.0	1.1	2.9
Lifetime Intake	1.0	1.2	2.7	-1.6	1.2	0.5	0.8
Liver weight, left	3.1	5.4	6.9	-2.4	1.7	2.4	2.6
Liver weight, right	2.2	3.9	5.4	-2.3	1.9	2.2	1.3
Locomotor activity	0.5	0.8	2.8	-0.7	-0.1	0.0	1.7
Locomotor testing distance	1.1	2.8	8.6	-1.1	0.8	0.9	2.9
Locomotor testing rearing	0.6	2.2	6.9	-0.7	0.8	0.8	2.6
Locomotion in novel chamber	0.2	0.2	0.7	-0.2	0.0	-0.8	0.4
Locomotion in novel chamber post-restriction	0.2	0.7	1.6	-0.8	0.1	0.7	-1.3
Fecal boli incidents, locomotor time 1	0.2	0.5	1.5	0.2	0.4	-0.5	-1.2
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.1	-0.3	0.1	0.2
Time >=10cm from walls, locomotor time 1	1.6	2.0	5.8	0.9	0.6	-1.0	-2.4
Bouts of movement, locomotor time 1	0.5	0.6	1.1	0.6	-0.9	0.3	1.1
Total resting periods, locomotor time 1	0.4	0.4	0.6	0.6	-0.8	0.5	0.7
Rest time, locomotor task time 1	0.3	0.5	1.5	-0.0	-1.2	-0.6	0.3
Distance moved, locomotor task time 1	0.3	0.8	1.1	-0.5	1.1	0.9	0.9
Vertical activity count, locomotor time 1	0.1	0.4	0.6	0.1	0.8	0.7	0.7
Time >=10cm from walls, locomotor time 2	0.1	0.4	0.6	-0.7	0.8	0.4	-0.3
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.2	0.1	-0.0	-0.2
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.1	-0.2	-0.3	-0.1
Rest time, locomotor task time 2	1.0	1.6	3.0	1.0	-1.4	-1.7	0.8
Distance moved, locomotor task time 2	1.3	1.8	2.1	-1.3	1.2	1.4	1.4
Vertical activity count, locomotor time 2	0.4	1.0	1.7	-1.0	0.6	0.9	1.3
Light reinforcement 1	0.4	1.9	3.2	-1.3	1.5	1.8	0.6
Light reinforcement 2	0.4	0.9	2.5	-0.9	1.6	0.2	-0.7
Bone: marrow area	0.2	0.4	1.0	-0.5	0.5	1.0	-0.2
Bone: maximum diameter	0.2	0.3	0.7	0.5	0.8	0.2	-0.6
Bone: maximum force	0.2	0.5	1.3	1.1	-0.4	-0.6	-0.2
Bone: maximum moment	0.2	0.3	0.9	1.0	-0.2	-0.5	-0.4
Mean time between licks in bursts	0.1	0.4	0.9	0.1	0.7	0.4	-0.9
Mean num. licks in bursts	0.3	0.7	1.9	-0.0	0.8	0.5	1.4
Cd content in liver	0.4	0.5	1.1	0.6	-0.5	-0.3	1.0
Co content in liver	0.8	1.0	3.0	-0.6	0.2	0.7	1.7
Cu content in liver	0.0	0.0	0.1	0.1	0.0	-0.3	0.1
Fe content in liver	1.2	1.4	2.0	1.4	-1.3	-1.1	-0.9
K content in liver	1.1	1.1	1.8	-1.1	0.9	1.3	0.6
Mg content in liver	0.5	0.6	1.0	0.9	-0.7	-1.0	-0.3
Mn content in liver	2.3	2.6	3.7	1.9	-1.9	-1.7	-0.6
Na content in liver	0.7	0.8	1.3	-0.9	1.0	1.1	0.3
Rb content in liver	0.1	0.1	0.3	0.2	0.1	-0.2	0.6
Se content in liver	1.2	1.4	2.8	1.2	-1.7	-1.2	0.2
Sr content in liver	0.2	0.1	0.5	0.1	-0.3	0.7	-0.1
Zn content in liver	0.1	0.1	0.3	-0.4	0.4	-0.1	0.5
Bone: minimum diameter	2.8	5.4	9.7	3.1	-2.0	-2.5	-1.2
Time in familiar zone, hab. session 1	0.1	0.2	0.3	-0.6	0.5	-0.1	-0.1
Time in novel zone, hab. session 1	0.8	0.9	1.6	-0.5	0.4	1.3	1.2
Total zone transitions, hab. session 1	0.3	0.4	1.1	0.2	-1.1	-0.5	-0.3
Total locomotion distance, hab. session 1	0.5	0.7	1.0	0.8	-0.9	-0.6	-1.0
Locomotion velocity, hab. session 1	1.0	1.4	2.4	1.1	-1.0	-0.9	-1.5
Time in familiar zone, hab. session 2	1.3	1.5	3.0	-1.3	1.7	1.0	0.6
Time in novel zone, hab. session 2	0.2	0.2	0.6	0.1	-0.8	-0.1	0.5
Total zone transitions, hab. session 2	0.3	0.4	1.3	-1.1	-0.1	0.6	0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.3	0.0	-0.5	-0.4	-0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.4	-0.1	-0.6	-0.3	-0.2
Novel to familiar place preference ratio	0.1	0.2	0.3	0.5	-0.2	-0.5	0.3
Novelty place preference	0.1	0.2	0.3	0.5	-0.2	-0.4	0.6
Time in novel zone, NPP test	0.2	0.2	0.3	0.6	-0.2	-0.5	0.5
Total zone transitions, NPP test	0.3	0.4	1.1	-0.1	-1.1	-0.4	-0.6
Total locomotion distance, NPP test	1.4	1.9	2.7	1.1	-1.6	-1.6	-1.1
Locomotion velocity, NPP test	1.2	1.7	2.6	1.0	-1.6	-1.5	-1.1
Intraocular pressure	1.7	2.7	4.8	1.6	-2.2	-1.8	-0.4
Delta distance traveled before/after self-admin	1.0	1.1	2.8	-1.1	0.5	1.7	0.7
Delta ambulatory time before/after self-admin	0.9	1.6	3.0	-1.2	0.3	1.7	1.3
Parametrial fat weight	0.1	0.3	0.6	-0.5	0.4	0.4	0.8
Pavlov. Cond. lever latency	0.3	0.4	0.7	0.9	-0.7	-0.6	0.3
Pavlov. Cond. magazine entry latency	2.7	3.5	6.2	-2.0	1.8	2.5	0.4
Pavlov. Cond. change in total contacts	0.6	0.6	1.5	-0.6	0.7	1.2	0.2
Pavlov. Cond. index score	1.6	2.0	3.3	-1.6	1.5	1.8	0.1
Pavlov. Cond. latency score	1.2	1.6	2.4	-1.4	1.5	1.5	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.3	0.3	0.4	-0.5
Pavlov. Cond. magazine entry number	5.0	6.3	10.7	2.7	-2.4	-3.3	-1.3
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.4	0.9	-1.2	-1.0	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	2.9	-1.4	1.3	1.7	0.1
Pavlov. Cond. response bias	2.7	3.4	5.9	-2.0	1.7	2.4	0.7
Pavlov. Cond. lever latency	0.4	0.5	1.1	-0.3	0.9	-0.1	-1.1
Pavlov. Cond. magazine entry latency	1.7	2.5	3.5	-1.4	1.1	1.8	1.9
Pavlov. Cond. change in total contacts	0.1	0.2	0.6	0.5	-0.8	-0.1	0.3
Pavlov. Cond. index score	0.5	0.8	2.4	-0.4	-0.1	0.9	1.5
Pavlov. Cond. latency score	0.8	1.2	3.2	-0.7	0.2	1.1	1.8
Pavlov. Cond. lever contacts	0.5	0.7	1.4	0.5	-1.1	-0.1	1.2
Pavlov. Cond. magazine entry number	0.9	1.2	2.1	0.8	-0.8	-1.2	-1.4
Pavlov. Cond. intertrial magazine entries	0.4	0.9	2.1	0.9	-0.4	-0.7	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	3.1	-0.5	-0.1	0.8	1.8
Pavlov. Cond. response bias	0.3	0.4	1.2	0.3	-0.6	0.2	1.1
Time in closed arm before self-admin	0.8	1.5	2.4	1.3	-1.6	-0.7	-1.2
Time in closed arm after self-admin	1.4	1.6	2.6	1.2	-1.0	-1.2	-1.6
Time in open arm before self-admin	2.8	3.4	5.5	-2.3	2.3	1.7	0.5
Time in open arm after self-admin	3.6	4.0	7.9	-2.0	0.9	1.9	2.8
Bone: periosteal estimation	0.3	0.7	1.8	1.4	-0.1	-0.6	-0.8
Bone: periosteal perimeter	0.5	1.0	2.4	1.6	0.1	-0.6	-1.2
Bone: post-yield work	0.1	0.2	0.5	-0.2	0.4	0.7	-0.5
Progressive ratio test 1 active lever presses	0.2	0.4	1.0	-1.0	0.6	0.3	0.2
Progressive ratio test 1 breakpoint	0.2	0.3	0.8	-0.9	0.5	0.2	0.2
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.5	-0.7	0.3	0.1	-0.3
Progressive ratio test 2 active lever presses	1.0	1.5	2.6	-1.6	1.2	0.9	1.1
Progressive ratio test 2 breakpoint	1.0	1.3	2.4	-1.5	1.0	0.8	1.1
Progressive ratio test 2 inactive lever presses	0.2	0.5	0.8	-0.9	0.8	0.5	0.6
Incentive Sensitization - Responses	0.6	1.8	2.5	-1.3	0.7	1.5	1.6
Incentive Sensitization - Breakpoint	0.8	1.7	2.6	-1.3	0.7	1.4	1.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.4	0.4	0.2	-0.2
Progressive ratio	0.3	1.0	2.6	-0.0	-1.0	0.5	1.6
Food seeking constrained by brief footshock	1.0	1.3	2.5	-1.6	0.7	1.4	0.4
Seeking ratio, punishment vs. effort	0.5	1.1	1.7	-0.8	1.3	0.5	-1.3
Retroperitoneal fat weight	0.5	2.2	4.0	-1.8	0.7	1.0	2.0
Reaction time number correct	0.2	0.9	1.5	0.8	-1.2	-1.1	-0.1
Reaction time mean minus median	0.1	0.4	0.9	0.4	-1.0	-0.7	-0.3
Reaction time mean minus median AUC	0.0	0.1	0.2	0.0	-0.4	-0.3	-0.2
Reaction time num false alarms	0.1	0.2	0.5	-0.3	0.7	0.4	-0.0
Reaction time num false alarms AUC	0.2	0.5	1.4	-0.6	1.2	0.6	-0.0
Reaction time trials correct on left	0.2	0.9	1.5	0.8	-1.2	-1.1	-0.1
Reaction time trials on left	0.3	1.1	1.9	0.9	-1.4	-1.3	-0.0
Reaction time mean	1.4	3.0	5.0	1.8	-2.2	-1.9	0.4
Reaction time mean AUC	0.9	2.3	3.8	1.5	-1.9	-1.7	0.2
Median of all reaction times	1.7	2.6	3.8	1.8	-2.0	-1.8	0.5
Reaction time omissions	1.9	3.0	5.3	1.4	-2.0	-2.3	0.8
Reaction time false alarm rate	1.0	1.3	2.8	-1.0	1.7	1.2	-0.0
Reaction time premature initiation rate	2.3	3.6	5.1	-2.2	2.0	2.3	0.6
Reaction time premature initiations	0.4	1.1	1.8	-1.3	0.9	1.2	0.5
Std. dev. reaction times	0.5	1.6	3.2	1.0	-1.8	-1.5	-0.1
Reaction time trials completed	0.3	1.1	1.9	0.9	-1.4	-1.3	-0.0
Reaction time trials AUC	0.3	1.2	1.9	1.0	-1.4	-1.3	0.1
Run reversals in cocaine runway, females	0.7	0.7	1.5	-0.5	0.8	-0.7	-1.2
Run reversals in cocaine runway, males	0.5	0.6	1.7	0.4	0.0	-0.7	-1.3
Latency to leave start box in cocaine runway	1.0	1.4	3.8	0.8	-0.9	-0.3	-2.0
Latency to leave start box in cocaine runway, F	0.5	0.6	1.7	0.6	-0.5	0.3	-1.3
Latency to leave start box in cocaine runway, M	0.6	0.6	1.5	0.4	-0.4	-0.7	-1.2
Std. dev. time between licks in bursts	0.7	1.3	1.9	-1.2	1.4	1.2	-0.3
Total sessions with >9 infusions	0.7	0.8	2.3	-1.5	0.8	0.4	0.5
Short access day 1 total inactive lever presses	0.2	0.4	1.2	-1.1	0.5	0.2	0.2
Short access day 10 total inactive lever presses	0.2	1.2	2.2	1.3	-1.5	-0.6	-0.9
Short access day 1 total infusions	0.1	0.2	0.7	-0.9	0.4	0.2	-0.1
Short access day 10 total infusions	0.2	0.3	0.4	-0.6	0.7	-0.6	0.2
Short access total infusions	0.6	0.9	2.4	-1.5	0.9	0.3	0.2
Short access day 1 locomotion	0.1	0.2	0.5	-0.7	0.5	-0.1	0.2
Short access day 10 total locomotion	0.8	3.3	7.8	1.4	-1.4	-2.8	-1.1
Short access total locomotion	0.4	0.5	1.7	-0.2	0.3	-1.3	-0.5
One hour access (0.3 mA shock)	0.8	1.0	1.7	-1.3	1.3	0.4	0.5
Compulsive drug intake	0.1	0.2	0.4	-0.2	-0.6	0.4	-0.2
One hour access (shock baseline)	0.1	0.3	0.7	-0.5	0.9	-0.1	0.5
Social response proportion	6.0	7.6	10.8	2.7	-2.6	-3.3	-2.3
Social responses	1.4	1.9	3.2	1.3	-1.5	-1.8	-0.6
Social time	0.5	0.7	1.5	0.7	-1.2	-0.8	-0.4
Soleus weight	0.7	1.9	3.8	-0.8	1.6	0.9	-1.9
Bone: stiffness	0.1	0.2	0.5	0.4	-0.3	0.2	0.7
Tibialis anterior weight	2.0	6.8	9.7	2.4	-2.5	-3.1	-2.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.4	0.3	0.1	-0.4
Time to tail flick, vehicle, after self-admin	0.1	0.3	1.0	0.2	1.0	0.1	0.1
Time to tail flick, test, before self-admin	0.4	0.5	1.3	0.4	-0.5	-1.2	0.5
Time to tail flick, test, after self-admin	0.9	0.9	1.6	1.0	-1.3	-1.0	0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.0	0.3	-0.2	0.3
Delta time to tail flick, test, before/after SA	0.3	0.4	1.0	0.6	-0.5	0.1	-1.0
Tibia length	0.1	0.2	0.2	0.3	0.5	0.3	-0.4
Ambulatory time before self-admin	0.1	0.4	0.9	-0.8	0.9	0.2	0.2
Ambulatory time after self-admin	0.7	1.1	1.6	-1.1	0.5	1.3	1.1
Bone: tissue strength	0.4	0.4	0.9	0.9	-0.4	-0.5	-0.5
Total heroin consumption	0.7	0.9	1.6	1.3	-0.5	-0.8	-0.9
Bone: trabecular number	0.0	0.0	0.1	0.0	-0.1	0.3	0.1
Bone: trabecular spacing	0.8	1.2	1.5	1.2	-1.2	-1.2	0.3
Bone: trabecular thickness	1.9	2.6	3.8	1.7	-1.3	-1.4	-2.0
Bone: trabecular tissue density	0.2	0.3	0.5	-0.4	-0.7	-0.4	0.7
Water consumed over 24 hours	2.5	4.8	11.6	-2.3	0.9	1.3	3.4
Number of responses in last shaping day	0.9	1.2	2.5	-1.6	1.2	0.5	0.8