Hub : Genes

LOC134485820

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression LOC134485820 0.22 0.11 0.0e+00 0.23 0.22 0.22 0.22 6.9e-21 8.2e-20 2.0e-20 1.7e-20
2 IL gene expression LOC134485820 0.38 0.15 1.6e-07 0.26 0.17 0.16 0.13 4.7e-07 5.5e-05 1.5e-04 6.2e-04
3 PL gene expression LOC134485820 0.27 0.08 0.0e+00 0.3 0.3 0.31 0.31 2.7e-33 9.4e-34 4.3e-34 3.2e-34
4 IC gene expression LOC134485820 0.37 0.11 0.0e+00 0.39 0.39 0.36 0.4 1.5e-17 2.8e-17 8.1e-16 5.3e-18
5 OFC gene expression LOC134485820 0.49 0.15 5.0e-10 0.29 0.33 0.3 0.35 1.3e-07 9.6e-09 6.5e-08 3.2e-09
6 BLA gene expression LOC134485820 0.61 0.11 5.6e-17 0.19 0.26 0.24 0.27 3.2e-10 7.3e-14 3.6e-13 1.5e-14
7 NAcc gene expression LOC134485820 0.24 0.08 0.0e+00 0.27 0.3 0.3 0.3 5.5e-41 2.2e-46 2.0e-46 2.0e-46
8 Adipose gene expression LOC134485820 0.25 0.09 0.0e+00 0.21 0.22 0.22 0.22 1.2e-22 3.1e-24 4.9e-24 8.3e-24

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.61.11.61.01.11.01.11.31.11.10.6
Area under the delay curve2.52.96.3-1.4-1.2-1.6-1.1-1.3-2.5-1.5-2.3
BMI with tail2.58.711.1-3.0-3.1-3.1-3.0-3.3-2.9-3.2-1.8
BMI without tail1.95.88.2-2.6-2.9-2.6-2.9-2.8-1.6-2.50.2
Body weight2.611.214.4-3.6-3.8-3.7-3.7-3.7-2.8-3.5-0.8
Weight adjusted by age0.00.10.3-0.1-0.10.1-0.0-0.2-0.5-0.1-0.3
Bone surface0.00.00.30.10.1-0.00.10.2-0.00.1-0.6
Bone volume0.91.72.21.41.41.31.41.51.31.30.1
Breakpoint value in progressive ratio session0.30.31.20.40.50.30.50.2-0.80.3-1.1
Number of licking bursts0.20.30.7-0.3-0.5-0.5-0.5-0.8-0.2-0.7-0.1
Context. condit. distance diff. score0.80.91.51.01.01.01.01.20.61.10.6
Locomotion velocity, session 11.01.11.71.10.91.00.81.10.91.21.3
Locomotion distance, session 12.02.53.41.61.51.71.41.51.51.81.7
Locomotion velocity, session 20.81.01.81.00.81.00.81.00.61.31.2
Locomotion distance, session 22.02.73.41.81.61.81.51.61.61.81.6
Locomotion velocity, session 31.01.12.01.41.11.11.11.10.41.40.1
Locomotion distance, session 30.20.20.60.70.40.30.40.2-0.10.5-0.8
Stereotopy head waving bouts, day 31.31.51.91.01.11.31.21.31.31.21.4
Stereotopy head waving duration, day 30.00.00.1-0.3-0.10.00.00.0-0.2-0.10.3
Locomotion velocity, session 70.91.01.51.21.20.91.21.00.31.0-0.7
Locomotion distance, session 70.00.00.20.10.0-0.00.0-0.1-0.10.0-0.4
Stereotopy head waving bouts, day 70.40.40.90.70.40.70.50.70.20.90.9
Stereotopy head waving duration, day 70.10.10.30.30.10.30.20.4-0.30.50.5
Locomotion velocity, session 85.56.68.52.32.22.62.22.62.82.72.9
Locomotion distance, session 81.52.23.41.51.31.51.31.71.01.91.5
Degree of sensitization distance0.10.10.4-0.4-0.2-0.1-0.2-0.10.2-0.20.7
Degree of sensitization stereotypy0.10.10.20.50.10.20.10.1-0.40.50.1
Conditioned locomotion0.30.30.7-0.3-0.4-0.3-0.3-0.8-0.7-0.7-0.7
Cocaine response after cond. corrected0.10.10.30.10.30.00.20.1-0.40.0-0.5
Cocaine response after cond. not corrected0.00.00.2-0.3-0.0-0.1-0.10.2-0.40.00.0
Cocaine response before conditioning0.10.10.8-0.2-0.2-0.0-0.20.40.30.20.9
Saline control response0.91.21.9-1.2-1.2-1.0-1.2-1.4-1.3-1.00.2
Bone: connectivity density0.00.10.20.10.10.20.20.30.10.40.4
Bone: cortical apparent density2.43.34.72.22.11.92.01.91.81.70.0
Bone: cortical area0.10.20.90.40.50.20.40.2-0.10.1-0.9
Bone: cortical porosity0.20.20.7-0.10.20.00.2-0.3-0.7-0.2-0.8
Bone: cortical porosity0.20.20.70.10.30.20.3-0.3-0.6-0.0-0.8
Bone: cortical thickness0.50.91.41.21.20.91.10.90.40.9-0.7
Bone: cortical thickness0.70.81.0-0.9-0.8-1.0-0.8-1.0-0.7-1.0-0.9
Bone: cortical tissue density2.53.44.72.22.12.02.12.01.91.70.0
Condit. Reinf. active minus inactive responses0.20.20.80.20.00.2-0.0-0.00.70.20.9
Condit. Reinf. active-inactive response ratio0.20.21.3-0.1-0.3-0.1-0.4-0.10.60.01.1
Condit. Reinf. active responses0.10.10.50.20.10.20.1-0.10.50.20.7
Condit. Reinf. inactive responses0.10.10.10.30.40.30.40.20.10.30.1
Incentive salience index mean0.10.20.3-0.4-0.4-0.3-0.5-0.5-0.1-0.20.5
Condit. Reinf. lever presses0.20.20.8-0.3-0.3-0.4-0.3-0.5-0.9-0.3-0.5
Condit. Reinf. active minus inactive responses0.10.20.80.30.30.10.2-0.1-0.5-0.1-0.9
Condit. Reinf. active-inactive response ratio0.10.10.3-0.2-0.2-0.3-0.2-0.3-0.5-0.4-0.4
Condit. Reinf. active responses0.20.30.80.60.60.40.60.2-0.30.3-0.9
Condit. Reinf. inactive responses0.20.20.6-0.3-0.3-0.3-0.2-0.4-0.8-0.3-0.6
Condit. Reinf. lever presses0.30.41.20.70.60.40.70.4-0.00.3-1.1
Condit. Reinf. lever reinforcers received0.20.31.60.50.50.20.50.0-0.50.0-1.3
Conditioned reinforcement - actives0.30.53.3-0.4-0.5-0.1-0.50.10.40.21.8
Conditioned reinforcement - inactives0.00.10.1-0.4-0.2-0.2-0.4-0.2-0.3-0.30.2
Conditioned locomotion2.53.35.51.31.31.71.51.92.31.82.3
Patch foraging indifference point 0 sec0.71.31.9-1.2-1.2-1.3-1.3-1.2-0.5-1.4-0.5
Patch foraging indifference point AUC1.21.73.4-1.2-1.1-1.3-1.1-1.2-1.9-1.2-1.2
Delay disc. indifference point, 0s delay1.11.26.0-0.30.0-0.40.2-0.5-1.6-0.6-2.4
Delay disc. indifference point, 16s delay1.11.22.2-1.1-0.9-1.1-0.9-0.9-1.5-1.0-1.2
Delay disc. indifference point, 2s delay1.41.56.1-0.5-0.2-0.7-0.1-0.6-2.1-0.9-2.5
Delay disc. indifference point, 24s delay4.34.89.3-1.9-1.8-2.1-1.6-2.0-3.1-2.1-2.6
Delay disc. indifference point, 4s delay1.11.13.4-0.7-0.4-0.8-0.4-0.5-1.8-0.7-1.8
Delay disc. indifference point, 8s delay2.22.65.4-1.5-1.3-1.6-1.3-1.4-2.3-1.5-1.7
Indifference point function ln k0.40.81.70.60.50.70.50.91.30.81.3
Indifference point function log k0.40.81.70.60.50.70.50.91.30.81.3
Patch foraging total patch changes 0 sec0.61.21.8-1.1-1.2-1.3-1.2-1.1-0.5-1.3-0.5
Patch foraging total patch changes 12 sec1.72.23.3-1.5-1.3-1.6-1.3-1.7-1.2-1.8-1.4
Patch foraging total patch changes 18 sec1.72.53.9-1.3-1.3-1.6-1.4-1.7-1.6-1.7-2.0
Patch foraging total patch changes 24 sec3.86.67.8-2.7-2.5-2.7-2.5-2.7-2.7-2.8-1.8
Patch foraging total patch changes 6 sec1.21.82.5-1.2-1.2-1.5-1.2-1.3-1.2-1.6-1.5
Patch foraging time to switch 0 sec0.30.52.9-0.1-0.2-0.5-0.2-0.6-0.6-0.6-1.7
Patch foraging water rate 0 sec0.10.21.0-0.3-0.3-0.1-0.30.00.2-0.11.0
Patch foraging water rate 12 sec0.30.71.30.70.70.90.80.71.20.71.0
Patch foraging water rate 18 sec0.81.21.9-1.4-1.3-1.0-1.2-1.1-0.7-1.10.7
Patch foraging water rate 24 sec0.60.81.1-1.0-1.0-0.9-1.0-1.0-0.9-0.90.3
Patch foraging water rate 6 sec0.30.50.90.50.50.60.50.90.60.70.9
Seeking ratio, delayed vs. immediate footshock0.10.21.1-0.3-0.10.1-0.10.10.00.21.0
Distance traveled before self-admin0.60.81.6-0.7-0.7-0.9-0.7-0.8-1.2-0.9-1.3
Distance traveled after self-admin2.22.74.7-1.6-1.7-1.7-1.5-1.8-2.2-1.5-1.0
Extensor digitorum longus weight0.10.30.90.50.40.30.40.61.00.4-0.1
Bone: elastic displacement1.01.21.71.31.31.11.31.20.71.0-0.7
Bone: elastic work0.50.71.20.81.00.81.01.10.40.8-0.3
Bone: endosteal estimation0.30.61.1-0.9-0.7-0.8-0.7-0.7-0.4-1.0-0.5
Bone: endosteal perimeter0.10.30.5-0.7-0.5-0.6-0.5-0.5-0.4-0.6-0.5
Epididymis fat weight1.86.39.7-2.9-3.1-2.6-3.0-2.6-1.7-2.31.1
Delta time in closed arm before/after self-admin0.30.20.90.50.50.30.50.40.00.1-1.0
Delta time in open arm before/after self-admin0.00.00.10.00.10.0-0.0-0.1-0.40.1-0.2
Diff in mean of infusions in LGA sessions0.81.01.61.21.21.11.31.2-0.21.1-0.3
Delay discount exponential model param2.52.86.31.51.21.61.11.32.51.52.3
Extinction: sum of active levers before priming0.20.20.6-0.2-0.1-0.2-0.1-0.3-0.7-0.4-0.8
Active lever presses in extinction session 60.70.72.3-0.5-0.4-0.6-0.3-0.6-1.4-0.7-1.5
Bone: final force0.30.42.60.10.3-0.10.30.2-0.7-0.1-1.6
Bone: final moment0.30.42.80.10.3-0.10.30.1-0.7-0.2-1.7
Food consumed during 24 hour testing period1.82.53.3-1.4-1.4-1.7-1.5-1.6-1.5-1.8-1.8
Glucose3.25.08.12.32.22.22.12.42.82.21.3
Heart weight2.23.44.9-2.2-2.0-1.9-2.1-1.8-1.9-1.80.0
Delay discount hyperbolic model param2.32.55.81.41.11.41.01.22.41.42.2
Intermittent access intake day 1-15 change0.20.41.90.40.50.40.30.31.40.20.4
Intermittent access intake escalation0.10.21.30.30.40.30.20.21.10.10.2
Intermittent access intake escalation 20.10.10.60.40.40.40.30.00.80.20.1
Intermitt. access day 1 inactive lever presses0.31.11.91.21.41.11.31.00.10.9-1.0
Intermitt. access day 15 inactive lever presses0.20.41.90.50.70.30.60.4-0.30.2-1.4
Intermitt. access escalation Index0.00.10.20.20.20.00.00.10.50.0-0.4
Intermittent access day 1 total infusions4.06.58.2-2.8-2.9-2.8-2.8-2.5-2.8-2.5-0.9
Intermittent access day 15 total infusions0.91.31.9-1.3-1.3-1.3-1.4-1.2-0.8-1.2-0.4
Intermittent access terminal intake (last 3 days)0.70.91.4-1.1-1.1-1.0-1.2-1.1-0.9-1.0-0.1
Intermittent access total infusions1.61.92.4-1.5-1.6-1.5-1.6-1.4-1.2-1.4-0.6
Intermittent access day 1 locomotion0.91.12.3-1.1-1.1-1.1-1.1-0.7-1.5-0.8-0.5
Intermittent access day 15 total locomotion0.91.72.7-1.6-1.5-1.5-1.6-1.1-0.8-1.30.0
Intermittent access total locomotion0.20.20.3-0.5-0.5-0.5-0.5-0.3-0.4-0.5-0.4
Intermittent access standard deviation0.10.10.3-0.3-0.4-0.4-0.2-0.4-0.1-0.4-0.6
Left kidney weight4.520.827.4-5.2-5.1-4.8-5.1-5.1-3.8-4.9-0.6
Right kidney weight5.223.529.0-5.4-5.3-5.1-5.3-5.4-4.4-5.2-1.3
Cocaine induced anxiety0.20.30.90.40.50.50.60.90.10.80.1
Post-drug Anxiety0.30.31.10.10.10.30.20.70.30.61.0
Baseline Anxiety0.10.10.5-0.4-0.3-0.2-0.4-0.20.3-0.30.7
Tail length0.52.03.0-1.6-1.7-1.3-1.7-1.3-0.2-1.11.5
Length with tail0.83.45.2-2.2-2.3-1.8-2.3-1.7-0.9-1.51.5
Length without tail1.03.24.4-2.1-2.1-2.0-2.1-1.7-1.8-1.7-0.2
Times rat made contact with spout2.12.43.5-1.8-1.6-1.6-1.7-1.9-1.5-1.6-0.1
Lifetime Intake1.92.43.1-1.6-1.7-1.7-1.8-1.6-1.5-1.5-0.7
Liver weight, left5.79.511.3-3.3-3.4-3.3-3.3-3.4-2.8-3.3-1.4
Liver weight, right2.34.06.0-2.3-2.4-2.3-2.3-2.1-1.3-2.1-0.4
Locomotor activity0.00.10.10.1-0.4-0.2-0.4-0.2-0.30.10.1
Locomotor testing distance0.50.91.5-0.8-1.2-1.1-1.2-1.0-0.6-0.8-0.3
Locomotor testing rearing0.20.40.7-0.5-0.7-0.6-0.6-0.8-0.4-0.7-0.6
Locomotion in novel chamber0.50.71.20.90.91.10.80.40.80.70.6
Locomotion in novel chamber post-restriction0.20.31.30.20.10.3-0.10.40.40.51.2
Fecal boli incidents, locomotor time 10.60.91.8-0.9-0.9-0.8-1.0-1.3-0.6-1.2-0.3
Change in fecal boli incidents, locomotor task1.91.82.41.21.21.31.21.41.51.51.4
Time >=10cm from walls, locomotor time 13.03.17.11.11.21.61.31.82.31.72.7
Bouts of movement, locomotor time 10.30.31.80.40.40.10.40.1-0.20.1-1.3
Total resting periods, locomotor time 10.20.20.30.50.50.40.50.50.30.5-0.5
Rest time, locomotor task time 11.92.43.91.31.21.51.21.51.71.82.0
Distance moved, locomotor task time 11.11.62.1-1.3-1.1-1.3-1.1-1.2-1.4-1.5-1.3
Vertical activity count, locomotor time 10.51.31.7-1.2-1.1-1.1-1.1-1.1-1.2-1.3-1.0
Time >=10cm from walls, locomotor time 20.40.61.60.50.60.70.80.81.30.70.8
Bouts of movement, locomotor time 20.10.20.80.30.40.40.30.9-0.10.60.1
Total resting periods, locomotor time 20.10.30.80.40.50.40.40.9-0.10.70.1
Rest time, locomotor task time 20.30.40.90.50.40.50.40.60.60.70.9
Distance moved, locomotor task time 20.20.20.5-0.7-0.5-0.6-0.4-0.3-0.5-0.5-0.4
Vertical activity count, locomotor time 20.10.10.3-0.5-0.3-0.3-0.3-0.4-0.3-0.5-0.2
Light reinforcement 10.20.61.2-0.8-0.9-0.6-0.9-0.6-0.2-0.71.1
Light reinforcement 21.01.52.2-1.4-1.3-1.2-1.5-1.3-0.9-1.30.2
Bone: marrow area0.30.61.1-1.0-0.7-0.8-0.8-0.7-0.5-1.1-0.6
Bone: maximum diameter1.01.93.2-1.2-1.0-1.3-1.0-1.4-1.6-1.4-1.8
Bone: maximum force0.10.31.3-0.20.1-0.20.10.1-0.8-0.3-1.2
Bone: maximum moment0.20.31.5-0.20.1-0.20.1-0.0-0.8-0.3-1.2
Mean time between licks in bursts0.71.82.4-1.6-1.4-1.5-1.4-1.1-1.4-1.4-0.5
Mean num. licks in bursts0.20.41.0-0.7-0.5-0.6-0.5-0.4-1.0-0.4-0.5
Cd content in liver0.10.20.70.30.30.20.30.2-0.40.1-0.8
Co content in liver0.40.51.90.30.30.50.30.51.10.41.4
Cu content in liver0.20.21.0-0.2-0.20.0-0.10.60.20.21.0
Fe content in liver0.60.71.41.21.00.81.00.8-0.20.8-0.7
K content in liver0.90.82.0-0.8-0.7-0.9-0.8-0.7-1.4-0.9-0.8
Mg content in liver0.10.10.6-0.2-0.2-0.3-0.3-0.1-0.8-0.2-0.3
Mn content in liver1.61.82.71.61.61.41.61.40.61.2-0.7
Na content in liver0.80.91.3-1.2-1.0-0.9-1.0-0.8-1.1-0.80.7
Rb content in liver0.50.50.8-0.9-0.9-0.9-0.9-0.7-0.3-0.80.1
Se content in liver0.91.11.71.21.21.11.21.3-0.11.20.0
Sr content in liver0.60.60.80.80.80.80.80.70.90.70.1
Zn content in liver0.20.21.0-0.5-0.4-0.2-0.3-0.0-0.2-0.21.0
Bone: minimum diameter0.71.31.91.11.41.31.31.31.11.10.2
Time in familiar zone, hab. session 10.10.10.4-0.2-0.1-0.1-0.1-0.10.6-0.20.5
Time in novel zone, hab. session 10.80.80.9-0.9-0.9-0.9-0.9-0.9-0.9-0.8-0.6
Total zone transitions, hab. session 11.31.82.41.41.31.51.31.41.31.51.1
Total locomotion distance, hab. session 10.91.31.81.31.21.31.11.21.21.10.8
Locomotion velocity, hab. session 11.52.12.91.71.51.61.41.41.41.51.0
Time in familiar zone, hab. session 21.61.72.9-1.7-1.5-1.4-1.5-1.1-1.2-1.30.1
Time in novel zone, hab. session 20.60.61.11.00.90.80.90.40.80.6-0.5
Total zone transitions, hab. session 20.10.10.50.00.00.1-0.00.2-0.10.30.7
Total locomotion distance, hab. session 20.10.10.20.50.40.40.30.2-0.20.40.3
Locomotion velocity, hab. session 20.10.10.20.40.30.30.30.1-0.40.40.2
Novel to familiar place preference ratio0.00.00.10.30.10.10.10.0-0.10.1-0.3
Novelty place preference0.00.00.10.20.0-0.00.1-0.1-0.0-0.1-0.3
Time in novel zone, NPP test0.10.10.20.50.30.30.30.20.20.2-0.1
Total zone transitions, NPP test0.71.01.41.21.11.11.01.10.31.20.4
Total locomotion distance, NPP test1.21.62.61.61.41.41.31.21.01.40.7
Locomotion velocity, NPP test0.50.81.61.21.01.00.90.70.51.00.2
Intraocular pressure7.610.912.93.33.43.63.43.63.43.52.1
Delta distance traveled before/after self-admin1.31.43.1-1.1-1.2-1.1-1.0-1.3-1.8-1.0-0.6
Delta ambulatory time before/after self-admin0.81.01.6-1.0-1.1-1.0-1.0-1.1-1.3-0.8-0.0
Parametrial fat weight0.10.31.40.10.20.30.20.10.70.11.2
Pavlov. Cond. lever latency0.70.92.40.90.80.90.91.01.60.70.6
Pavlov. Cond. magazine entry latency1.21.62.3-1.5-1.5-1.2-1.5-1.3-0.8-1.00.9
Pavlov. Cond. change in total contacts0.10.10.2-0.3-0.3-0.2-0.3-0.4-0.2-0.10.5
Pavlov. Cond. index score1.21.52.2-1.3-1.3-1.2-1.3-1.3-1.5-1.1-0.1
Pavlov. Cond. latency score1.01.31.9-1.3-1.2-1.1-1.2-1.2-1.4-1.0-0.0
Pavlov. Cond. lever contacts0.10.20.7-0.4-0.3-0.3-0.3-0.3-0.8-0.1-0.0
Pavlov. Cond. magazine entry number2.43.04.22.02.01.82.11.91.41.6-0.5
Pavlov. Cond. intertrial magazine entries2.42.98.01.11.21.51.11.32.81.22.4
Pavlov. Cond. lever-magazine prob. diff.0.80.91.6-1.0-1.0-1.0-1.0-1.1-1.2-0.8-0.1
Pavlov. Cond. response bias1.51.92.5-1.5-1.6-1.4-1.6-1.5-1.4-1.20.1
Pavlov. Cond. lever latency0.40.52.5-0.7-0.6-0.3-0.7-0.1-0.2-0.11.6
Pavlov. Cond. magazine entry latency4.25.16.7-2.0-2.0-2.4-2.0-2.1-2.4-2.3-2.6
Pavlov. Cond. change in total contacts0.40.64.10.20.3-0.10.30.1-0.5-0.2-2.0
Pavlov. Cond. index score1.11.46.4-0.5-0.6-1.0-0.6-0.8-1.1-1.0-2.5
Pavlov. Cond. latency score1.62.27.5-0.9-0.9-1.4-0.9-1.2-1.4-1.4-2.7
Pavlov. Cond. lever contacts0.50.73.20.80.70.40.70.20.10.2-1.8
Pavlov. Cond. magazine entry number3.84.78.91.81.82.31.81.92.22.23.0
Pavlov. Cond. intertrial magazine entries0.30.50.90.70.60.80.70.50.10.90.9
Pavlov. Cond. lever-magazine prob. diff.1.31.87.1-0.7-0.8-1.2-0.7-1.0-1.3-1.2-2.7
Pavlov. Cond. response bias0.40.64.00.30.2-0.10.3-0.2-0.4-0.3-2.0
Time in closed arm before self-admin0.40.51.30.50.40.60.50.50.70.81.1
Time in closed arm after self-admin0.10.10.40.40.20.10.20.2-0.10.1-0.6
Time in open arm before self-admin1.81.92.9-1.7-1.7-1.5-1.6-1.0-1.4-1.20.1
Time in open arm after self-admin0.60.71.1-1.0-0.9-0.9-1.0-0.7-0.8-0.60.3
Bone: periosteal estimation0.10.31.6-0.3-0.1-0.3-0.1-0.3-0.4-0.6-1.3
Bone: periosteal perimeter0.10.20.7-0.4-0.3-0.5-0.4-0.3-0.5-0.4-0.9
Bone: post-yield work0.10.20.4-0.6-0.5-0.5-0.5-0.4-0.6-0.30.1
Progressive ratio test 1 active lever presses1.82.23.4-1.3-1.5-1.5-1.5-1.4-1.8-1.5-1.2
Progressive ratio test 1 breakpoint1.61.92.9-1.3-1.4-1.5-1.4-1.3-1.7-1.4-1.2
Progressive ratio test 1 inactive lever presses1.01.43.2-1.0-1.0-1.2-1.1-1.1-1.8-1.1-1.1
Progressive ratio test 2 active lever presses2.93.44.8-2.0-2.1-2.1-2.2-1.8-1.7-1.8-0.4
Progressive ratio test 2 breakpoint2.93.34.6-2.0-2.1-2.0-2.1-1.8-1.7-1.8-0.3
Progressive ratio test 2 inactive lever presses0.71.11.8-1.3-1.3-1.2-1.3-0.7-0.6-0.80.7
Incentive Sensitization - Responses1.82.54.1-1.9-1.9-1.8-2.0-1.6-0.9-1.60.3
Incentive Sensitization - Breakpoint1.72.33.7-1.8-1.8-1.7-1.9-1.5-0.8-1.50.5
Sum of active levers in priming session hrs 5-60.60.52.30.40.50.30.70.4-0.80.2-1.5
Progressive ratio0.00.10.20.30.10.10.00.1-0.50.1-0.3
Food seeking constrained by brief footshock0.00.10.2-0.00.10.10.10.40.30.10.4
Seeking ratio, punishment vs. effort0.00.10.2-0.3-0.2-0.2-0.10.10.4-0.20.2
Retroperitoneal fat weight0.83.44.9-2.1-2.2-1.8-2.2-2.1-0.6-1.81.3
Reaction time number correct0.91.62.31.51.51.41.51.21.11.20.2
Reaction time mean minus median0.10.21.10.10.1-0.10.10.1-0.2-0.1-1.1
Reaction time mean minus median AUC0.00.10.3-0.1-0.1-0.2-0.0-0.1-0.1-0.2-0.6
Reaction time num false alarms0.91.21.9-1.4-1.2-1.0-1.3-1.0-0.7-1.20.7
Reaction time num false alarms AUC1.11.72.7-1.6-1.5-1.3-1.6-1.1-0.8-1.40.9
Reaction time trials correct on left0.91.62.31.51.51.41.51.21.11.20.2
Reaction time trials on left1.12.02.81.71.71.61.71.41.21.40.1
Reaction time mean0.20.30.60.80.60.60.70.30.30.5-0.6
Reaction time mean AUC0.10.20.40.60.50.40.50.20.30.4-0.6
Median of all reaction times0.20.20.50.70.60.50.60.30.30.5-0.4
Reaction time omissions2.53.64.92.22.21.92.12.21.61.9-0.5
Reaction time false alarm rate2.43.25.1-2.3-2.1-1.8-2.2-1.6-1.3-1.80.7
Reaction time premature initiation rate1.62.33.7-1.8-1.9-1.6-1.9-1.4-0.6-1.30.8
Reaction time premature initiations0.20.30.6-0.7-0.8-0.5-0.7-0.40.2-0.40.8
Std. dev. reaction times0.10.30.50.70.60.40.50.40.30.4-0.6
Reaction time trials completed1.12.02.81.71.71.61.71.41.21.40.1
Reaction time trials AUC1.02.02.81.71.71.61.71.41.11.40.0
Run reversals in cocaine runway, females0.60.63.30.10.10.3-0.00.71.00.61.8
Run reversals in cocaine runway, males0.50.51.5-0.2-0.4-0.6-0.3-0.6-0.9-0.5-1.2
Latency to leave start box in cocaine runway0.40.41.6-0.1-0.1-0.3-0.2-0.4-1.0-0.5-1.3
Latency to leave start box in cocaine runway, F0.10.10.3-0.2-0.2-0.2-0.1-0.3-0.4-0.6-0.6
Latency to leave start box in cocaine runway, M0.20.21.00.20.2-0.10.00.1-0.80.1-1.0
Std. dev. time between licks in bursts1.62.23.0-1.7-1.6-1.5-1.6-1.6-1.3-1.7-0.4
Total sessions with >9 infusions1.21.41.9-1.2-1.3-1.3-1.4-1.3-1.2-1.3-0.4
Short access day 1 total inactive lever presses0.40.60.9-0.7-0.8-1.0-0.7-0.4-0.8-0.7-0.7
Short access day 10 total inactive lever presses0.71.82.81.31.51.51.71.50.71.50.4
Short access day 1 total infusions0.40.51.0-0.7-0.8-0.9-1.0-0.8-0.5-0.7-0.1
Short access day 10 total infusions0.70.91.7-0.7-0.8-1.0-0.9-1.0-1.1-0.9-1.3
Short access total infusions1.41.82.2-1.3-1.4-1.5-1.5-1.4-1.4-1.3-0.8
Short access day 1 locomotion0.00.00.1-0.1-0.2-0.1-0.20.00.3-0.10.3
Short access day 10 total locomotion1.12.03.51.81.81.51.91.00.61.1-1.2
Short access total locomotion0.20.20.40.60.50.50.50.30.10.4-0.2
One hour access (0.3 mA shock)0.70.81.3-1.1-0.9-0.9-1.0-1.0-0.5-1.1-0.1
Compulsive drug intake0.30.40.7-0.7-0.6-0.7-0.9-0.5-0.4-0.7-0.0
One hour access (shock baseline)0.10.20.3-0.4-0.4-0.4-0.2-0.4-0.3-0.5-0.5
Social response proportion7.07.99.73.03.12.92.92.93.12.91.0
Social responses3.64.78.22.02.12.11.92.22.92.11.9
Social time4.25.77.92.62.52.42.62.82.32.60.6
Soleus weight0.20.61.0-0.9-0.9-0.9-1.0-0.7-0.5-0.70.5
Bone: stiffness0.10.20.4-0.4-0.2-0.4-0.2-0.2-0.6-0.5-0.6
Tibialis anterior weight3.010.113.53.33.23.33.13.23.73.32.1
Time to tail flick, vehicle, before self-admin0.80.91.5-0.8-0.9-1.0-0.8-0.7-1.2-0.9-0.9
Time to tail flick, vehicle, after self-admin1.31.74.1-1.2-1.2-1.3-1.0-1.1-2.0-1.2-1.1
Time to tail flick, test, before self-admin1.31.38.60.0-0.0-0.60.1-0.7-0.8-0.8-2.9
Time to tail flick, test, after self-admin1.31.41.81.01.11.31.11.21.21.11.4
Delta time to tail flick, vehicle, before/after SA0.00.00.2-0.00.1-0.00.1-0.1-0.5-0.1-0.4
Delta time to tail flick, test, before/after SA4.34.411.91.31.41.91.32.02.42.03.5
Tibia length0.41.02.3-1.0-0.9-0.9-0.9-1.3-1.5-0.8-0.5
Ambulatory time before self-admin0.71.01.7-0.8-0.8-1.0-0.7-0.9-1.3-1.0-1.3
Ambulatory time after self-admin1.51.83.8-1.1-1.2-1.3-1.0-1.4-2.0-1.2-1.4
Bone: tissue strength0.20.20.40.50.50.50.50.6-0.10.60.3
Total heroin consumption0.80.91.51.21.21.11.20.80.01.0-0.5
Bone: trabecular number0.00.10.20.20.10.20.20.30.10.30.4
Bone: trabecular spacing0.50.62.8-0.1-0.1-0.5-0.2-0.5-1.1-0.5-1.7
Bone: trabecular thickness4.65.87.62.42.42.52.42.52.82.41.6
Bone: trabecular tissue density0.20.30.40.60.60.50.60.60.20.5-0.3
Water consumed over 24 hours1.52.02.9-1.6-1.5-1.5-1.6-1.7-0.7-1.6-0.5
Number of responses in last shaping day0.70.82.0-0.6-0.7-1.0-0.8-0.8-0.6-1.0-1.4