Hub : Genes

LOC134485267

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	intron excision ratio	chr1_269851730_269854168	0.02	0.02	8.7e-03	0.03	0.02	0.02	0.02	1.9e-03	4.0e-03	6.9e-03	3.0e-03
2	NAcc	intron excision ratio	chr1_269851730_269854168	0.07	0.04	4.2e-07	0.02	0.04	0.04	0.04	1.2e-03	5.0e-07	6.2e-07	1.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	4.7	8.7	13.2	-2.1	3.6
Area under the delay curve	1.4	2.1	3.1	-1.1	-1.8
BMI with tail	26.7	93.3	112.5	-10.6	8.6
BMI without tail	10.9	57.9	70.4	-8.4	6.7
Body weight	24.6	107.5	123.6	-11.1	9.6
Weight adjusted by age	1.9	5.7	6.9	-2.6	2.1
Bone surface	3.4	6.7	8.4	-2.2	2.9
Bone volume	5.2	10.4	11.7	-3.0	3.4
Breakpoint value in progressive ratio session	1.7	3.2	6.3	-2.5	0.2
Number of licking bursts	0.0	0.0	0.0	-0.2	0.2
Context. condit. distance diff. score	0.2	0.2	0.4	0.1	0.6
Locomotion velocity, session 1	1.0	1.1	1.7	1.3	-0.7
Locomotion distance, session 1	1.7	2.1	2.3	1.4	-1.5
Locomotion velocity, session 2	1.0	1.2	1.9	1.4	-0.8
Locomotion distance, session 2	0.3	0.4	0.5	-0.7	0.6
Locomotion velocity, session 3	1.4	1.6	1.7	1.2	-1.3
Locomotion distance, session 3	0.6	0.7	1.1	1.1	-0.6
Stereotopy head waving bouts, day 3	0.8	1.0	1.5	0.7	-1.2
Stereotopy head waving duration, day 3	1.6	2.0	3.6	0.6	-1.9
Locomotion velocity, session 7	0.0	0.0	0.0	0.0	0.0
Locomotion distance, session 7	1.0	1.2	2.3	-0.3	1.5
Stereotopy head waving bouts, day 7	2.7	3.2	6.1	-0.6	-2.5
Stereotopy head waving duration, day 7	2.9	3.6	7.1	-0.3	-2.7
Locomotion velocity, session 8	0.8	1.0	2.0	1.4	0.2
Locomotion distance, session 8	0.6	0.9	1.2	0.8	1.1
Degree of sensitization distance	2.6	2.8	4.1	-1.2	2.0
Degree of sensitization stereotypy	1.8	2.0	3.2	-0.9	-1.8
Conditioned locomotion	0.2	0.2	0.3	0.2	-0.6
Cocaine response after cond. corrected	1.9	2.8	5.6	2.4	-0.0
Cocaine response after cond. not corrected	3.0	4.3	8.6	2.9	-0.1
Cocaine response before conditioning	0.2	0.2	0.4	0.6	0.2
Saline control response	1.0	1.3	1.5	1.1	-1.2
Bone: connectivity density	1.1	1.8	3.3	-0.6	1.8
Bone: cortical apparent density	6.1	9.6	15.5	3.9	-1.9
Bone: cortical area	9.8	15.9	18.7	-4.3	3.6
Bone: cortical porosity	0.8	0.9	1.1	-1.0	0.8
Bone: cortical porosity	2.2	2.4	3.4	-1.9	1.2
Bone: cortical thickness	5.8	9.7	11.1	-3.3	2.9
Bone: cortical thickness	4.1	5.1	9.4	-3.1	0.8
Bone: cortical tissue density	6.6	10.4	16.9	4.1	-2.0
Condit. Reinf. active minus inactive responses	1.4	1.6	1.6	1.2	1.3
Condit. Reinf. active-inactive response ratio	1.0	1.1	2.1	1.5	0.2
Condit. Reinf. active responses	3.0	3.9	7.8	-0.2	2.8
Condit. Reinf. inactive responses	4.9	6.4	10.2	-1.6	3.2
Incentive salience index mean	1.4	1.8	2.7	0.9	1.6
Condit. Reinf. lever presses	0.7	1.0	1.7	0.6	1.3
Condit. Reinf. active minus inactive responses	1.5	2.4	3.4	-1.9	1.1
Condit. Reinf. active-inactive response ratio	1.6	2.5	4.8	-2.2	0.4
Condit. Reinf. active responses	2.3	3.4	4.0	-2.0	1.7
Condit. Reinf. inactive responses	0.9	1.4	2.2	-0.8	1.5
Condit. Reinf. lever presses	1.7	2.5	2.5	-1.6	1.6
Condit. Reinf. lever reinforcers received	1.6	2.3	2.6	-1.4	1.6
Conditioned reinforcement - actives	0.6	2.6	3.6	1.9	-1.3
Conditioned reinforcement - inactives	0.2	0.7	0.8	0.9	-0.7
Conditioned locomotion	2.4	3.5	5.5	2.3	-1.3
Patch foraging indifference point 0 sec	2.5	7.1	10.9	-3.3	1.8
Patch foraging indifference point AUC	0.1	0.3	0.4	-0.3	-0.6
Delay disc. indifference point, 0s delay	0.6	0.7	1.3	-1.2	-0.2
Delay disc. indifference point, 16s delay	1.1	1.6	2.8	-0.6	-1.7
Delay disc. indifference point, 2s delay	1.2	1.3	2.4	-0.4	-1.5
Delay disc. indifference point, 24s delay	1.1	1.7	2.4	-1.0	-1.6
Delay disc. indifference point, 4s delay	1.5	1.6	2.4	-0.9	-1.5
Delay disc. indifference point, 8s delay	1.0	1.6	3.1	-0.5	-1.7
Indifference point function ln k	0.3	0.9	1.7	-0.1	1.3
Indifference point function log k	0.3	0.9	1.7	-0.1	1.3
Patch foraging total patch changes 0 sec	2.8	8.3	12.7	-3.6	2.0
Patch foraging total patch changes 12 sec	3.3	4.4	6.9	-2.6	1.4
Patch foraging total patch changes 18 sec	1.3	3.0	4.2	-2.0	1.4
Patch foraging total patch changes 24 sec	0.2	0.6	1.3	-1.1	0.0
Patch foraging total patch changes 6 sec	2.6	4.4	7.2	-2.7	1.3
Patch foraging time to switch 0 sec	0.3	1.2	1.8	1.4	-0.7
Patch foraging water rate 0 sec	0.8	3.2	4.8	-2.2	1.2
Patch foraging water rate 12 sec	0.8	3.3	5.2	-2.3	1.2
Patch foraging water rate 18 sec	0.4	1.0	1.5	-1.2	0.7
Patch foraging water rate 24 sec	1.9	2.7	4.0	-2.0	1.2
Patch foraging water rate 6 sec	1.4	2.0	2.2	-1.5	1.4
Seeking ratio, delayed vs. immediate footshock	4.4	6.3	12.0	3.5	-0.8
Distance traveled before self-admin	1.5	3.2	3.7	1.6	-1.9
Distance traveled after self-admin	2.0	3.5	3.9	1.7	-2.0
Extensor digitorum longus weight	1.3	5.3	6.4	-2.1	2.5
Bone: elastic displacement	0.5	0.6	1.2	-0.3	-1.1
Bone: elastic work	1.2	1.5	3.0	-1.7	-0.3
Bone: endosteal estimation	1.6	4.0	4.7	-2.2	1.8
Bone: endosteal perimeter	1.8	4.4	7.6	-2.8	1.1
Epididymis fat weight	18.8	94.9	109.6	-10.5	9.0
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	0.4	0.7
Delta time in open arm before/after self-admin	1.1	1.3	1.5	-1.1	1.2
Diff in mean of infusions in LGA sessions	0.8	1.4	2.1	-1.5	-0.8
Delay discount exponential model param	1.8	2.4	3.7	1.1	1.9
Extinction: sum of active levers before priming	0.5	0.8	1.6	-1.3	0.2
Active lever presses in extinction session 6	2.5	2.5	4.9	-2.2	-0.3
Bone: final force	7.2	11.8	14.1	-3.7	3.1
Bone: final moment	8.0	12.9	14.5	-3.8	3.4
Food consumed during 24 hour testing period	0.4	0.8	1.1	-0.8	1.0
Glucose	4.8	7.6	14.1	-3.8	1.0
Heart weight	13.3	21.5	26.3	-5.1	4.1
Delay discount hyperbolic model param	2.0	2.6	4.0	1.1	2.0
Intermittent access intake day 1-15 change	0.1	0.7	1.4	0.3	-1.2
Intermittent access intake escalation	0.1	0.4	0.8	0.1	-0.9
Intermittent access intake escalation 2	0.0	0.0	0.1	-0.3	-0.1
Intermitt. access day 1 inactive lever presses	0.1	1.3	1.7	-1.3	0.9
Intermitt. access day 15 inactive lever presses	0.2	1.1	2.1	-1.5	-0.4
Intermitt. access escalation Index	0.2	0.5	0.6	0.6	0.8
Intermittent access day 1 total infusions	0.2	0.5	0.6	0.8	-0.6
Intermittent access day 15 total infusions	0.5	1.1	1.8	0.7	-1.3
Intermittent access terminal intake (last 3 days)	0.5	0.8	1.4	0.5	-1.2
Intermittent access total infusions	0.8	0.9	1.2	1.1	-0.8
Intermittent access day 1 locomotion	1.2	2.1	2.3	1.5	-1.4
Intermittent access day 15 total locomotion	0.3	1.1	2.2	0.3	-1.5
Intermittent access total locomotion	1.3	1.6	2.1	1.5	-1.0
Intermittent access standard deviation	0.2	1.2	2.3	-0.5	-1.5
Left kidney weight	5.3	42.6	47.4	-6.9	6.1
Right kidney weight	7.3	51.1	51.6	-7.1	7.2
Cocaine induced anxiety	1.1	2.9	4.1	2.0	-1.3
Post-drug Anxiety	0.2	0.2	0.3	0.4	0.6
Baseline Anxiety	1.7	2.9	3.5	-1.9	1.5
Tail length	0.2	1.0	1.3	-1.1	0.8
Length with tail	2.2	9.8	10.6	-3.3	3.0
Length without tail	2.8	14.9	16.1	-4.0	3.7
Times rat made contact with spout	1.6	1.8	1.9	-1.3	1.4
Lifetime Intake	0.8	0.9	1.2	1.1	-0.8
Liver weight, left	10.5	18.1	20.2	-4.5	4.0
Liver weight, right	7.0	12.2	16.5	-2.8	4.1
Locomotor activity	0.1	0.2	0.3	0.6	-0.0
Locomotor testing distance	0.3	0.8	1.5	1.2	-0.4
Locomotor testing rearing	0.3	1.0	1.8	0.4	-1.3
Locomotion in novel chamber	0.3	0.4	0.5	-0.5	0.7
Locomotion in novel chamber post-restriction	0.2	0.7	1.2	-0.3	-1.1
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	-0.5	-0.3
Change in fecal boli incidents, locomotor task	1.3	1.3	2.3	-0.6	1.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.4	0.2
Bouts of movement, locomotor time 1	0.2	0.3	0.4	-0.5	0.6
Total resting periods, locomotor time 1	0.3	0.3	0.5	-0.5	0.7
Rest time, locomotor task time 1	0.5	0.7	1.2	-0.6	1.1
Distance moved, locomotor task time 1	0.3	0.8	1.7	-0.1	-1.3
Vertical activity count, locomotor time 1	0.1	0.7	1.3	0.4	-1.1
Time >=10cm from walls, locomotor time 2	0.2	0.5	0.7	-0.5	0.8
Bouts of movement, locomotor time 2	0.1	0.2	0.3	0.4	-0.5
Total resting periods, locomotor time 2	0.1	0.3	0.4	0.4	-0.6
Rest time, locomotor task time 2	0.1	0.1	0.1	0.4	-0.3
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.3	0.0
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.0	0.3
Light reinforcement 1	0.0	0.2	0.3	0.5	0.4
Light reinforcement 2	0.1	0.3	0.7	0.8	-0.1
Bone: marrow area	1.8	4.4	5.2	-2.3	1.9
Bone: maximum diameter	4.9	9.9	13.1	-3.6	2.6
Bone: maximum force	5.6	11.1	11.2	-3.3	3.3
Bone: maximum moment	6.3	11.9	12.6	-3.3	3.6
Mean time between licks in bursts	0.2	1.2	2.0	0.7	1.4
Mean num. licks in bursts	0.1	0.4	0.4	-0.6	0.6
Cd content in liver	0.4	0.4	0.8	0.9	-0.3
Co content in liver	0.2	0.2	0.2	-0.4	0.4
Cu content in liver	0.0	0.0	0.0	0.1	-0.2
Fe content in liver	1.4	1.8	3.0	-0.7	1.7
K content in liver	0.1	0.1	0.1	0.1	-0.4
Mg content in liver	0.6	0.7	1.3	0.2	-1.1
Mn content in liver	0.2	0.2	0.4	-0.6	0.0
Na content in liver	1.2	1.4	2.3	-1.5	-0.7
Rb content in liver	0.1	0.1	0.2	-0.1	-0.5
Se content in liver	0.3	0.3	0.5	0.7	-0.4
Sr content in liver	5.9	5.1	6.5	1.9	-2.5
Zn content in liver	1.3	1.5	1.6	1.2	-1.3
Bone: minimum diameter	5.1	9.8	12.8	-3.6	2.6
Time in familiar zone, hab. session 1	1.4	1.6	3.1	-1.8	-0.2
Time in novel zone, hab. session 1	2.0	2.3	4.4	2.1	-0.4
Total zone transitions, hab. session 1	0.2	0.3	0.5	-0.1	-0.7
Total locomotion distance, hab. session 1	0.0	0.1	0.1	0.3	0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.2	0.5
Time in familiar zone, hab. session 2	0.3	0.3	0.5	-0.2	0.7
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.1	-0.5
Total zone transitions, hab. session 2	0.1	0.1	0.1	-0.3	-0.4
Total locomotion distance, hab. session 2	0.5	0.7	0.9	-0.9	0.8
Locomotion velocity, hab. session 2	0.6	0.7	1.1	-1.0	0.6
Novel to familiar place preference ratio	0.4	0.6	1.1	0.1	1.1
Novelty place preference	0.3	0.3	0.6	0.2	0.8
Time in novel zone, NPP test	0.5	0.6	1.2	-0.0	1.1
Total zone transitions, NPP test	0.5	0.8	1.3	-0.5	1.1
Total locomotion distance, NPP test	0.5	0.7	1.4	-0.3	1.2
Locomotion velocity, NPP test	0.4	0.5	1.1	-0.0	1.0
Intraocular pressure	0.1	0.2	0.3	-0.4	0.5
Delta distance traveled before/after self-admin	0.2	0.2	0.3	0.4	-0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	0.3	-0.3
Parametrial fat weight	29.9	70.4	79.6	-8.9	7.8
Pavlov. Cond. lever latency	0.7	0.8	0.9	0.9	-0.9
Pavlov. Cond. magazine entry latency	1.4	1.8	2.4	-1.1	1.5
Pavlov. Cond. change in total contacts	3.5	3.8	3.8	-1.9	1.9
Pavlov. Cond. index score	1.5	1.9	2.3	-1.3	1.5
Pavlov. Cond. latency score	1.3	1.6	1.8	-1.2	1.3
Pavlov. Cond. lever contacts	1.1	1.3	1.9	-1.4	0.8
Pavlov. Cond. magazine entry number	1.5	1.9	2.5	1.1	-1.6
Pavlov. Cond. intertrial magazine entries	3.3	4.0	6.0	-1.4	2.4
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.5	3.1	-1.4	1.7
Pavlov. Cond. response bias	1.0	1.3	1.5	-1.0	1.2
Pavlov. Cond. lever latency	1.4	2.0	3.0	1.0	-1.7
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.4	-0.1
Pavlov. Cond. change in total contacts	0.2	0.4	0.7	-0.4	0.8
Pavlov. Cond. index score	0.5	0.7	1.1	-0.6	1.1
Pavlov. Cond. latency score	0.4	0.7	1.1	-0.5	1.1
Pavlov. Cond. lever contacts	1.0	1.5	2.0	-0.9	1.4
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	0.3	0.0
Pavlov. Cond. intertrial magazine entries	1.2	2.7	3.0	-1.7	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	-0.5	0.7
Pavlov. Cond. response bias	1.0	1.4	2.1	-0.8	1.5
Time in closed arm before self-admin	0.0	0.1	0.1	0.1	-0.3
Time in closed arm after self-admin	0.4	0.5	0.9	0.9	-0.2
Time in open arm before self-admin	1.5	1.8	1.9	1.3	-1.4
Time in open arm after self-admin	0.1	0.1	0.2	-0.5	-0.1
Bone: periosteal estimation	6.4	15.2	17.4	-4.2	3.6
Bone: periosteal perimeter	6.6	13.0	19.9	-4.5	2.5
Bone: post-yield work	2.0	3.5	6.4	-0.7	2.5
Progressive ratio test 1 active lever presses	1.0	1.7	2.0	1.2	-1.4
Progressive ratio test 1 breakpoint	0.9	1.5	1.9	1.0	-1.4
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	0.3	-0.3
Progressive ratio test 2 active lever presses	0.3	0.4	0.8	0.2	-0.9
Progressive ratio test 2 breakpoint	0.2	0.3	0.6	0.2	-0.8
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.3	0.5	0.4
Incentive Sensitization - Responses	0.1	0.2	0.3	-0.6	-0.1
Incentive Sensitization - Breakpoint	0.0	0.1	0.2	-0.4	-0.1
Sum of active levers in priming session hrs 5-6	0.6	0.5	0.8	-0.9	0.5
Progressive ratio	1.9	5.5	6.7	2.1	-2.6
Food seeking constrained by brief footshock	5.4	6.7	8.2	2.3	-2.9
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	0.1	0.4
Retroperitoneal fat weight	31.4	140.4	154.7	-12.4	11.2
Reaction time number correct	0.1	0.2	0.4	-0.7	0.2
Reaction time mean minus median	0.2	1.1	2.2	0.1	-1.5
Reaction time mean minus median AUC	0.4	2.7	5.4	-0.1	-2.3
Reaction time num false alarms	1.0	1.6	2.7	-0.7	1.7
Reaction time num false alarms AUC	0.7	1.5	2.0	-1.0	1.4
Reaction time trials correct on left	0.1	0.2	0.4	-0.7	0.2
Reaction time trials on left	0.1	0.2	0.4	-0.7	0.2
Reaction time mean	2.4	5.3	8.8	1.3	-3.0
Reaction time mean AUC	2.6	6.2	10.1	1.5	-3.2
Median of all reaction times	3.8	6.0	9.4	1.6	-3.1
Reaction time omissions	0.1	0.2	0.2	0.3	-0.5
Reaction time false alarm rate	0.9	1.2	1.9	-0.8	1.4
Reaction time premature initiation rate	0.1	0.2	0.4	0.2	-0.6
Reaction time premature initiations	0.0	0.1	0.2	-0.3	-0.4
Std. dev. reaction times	0.3	1.1	2.1	-0.1	-1.5
Reaction time trials completed	0.1	0.2	0.4	-0.7	0.2
Reaction time trials AUC	0.1	0.5	0.8	-0.9	0.4
Run reversals in cocaine runway, females	0.7	0.8	1.1	0.7	-1.0
Run reversals in cocaine runway, males	0.5	0.5	0.8	0.5	-0.9
Latency to leave start box in cocaine runway	1.0	1.4	2.6	0.5	-1.6
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.1	-0.5
Latency to leave start box in cocaine runway, M	1.5	1.4	2.8	0.2	-1.7
Std. dev. time between licks in bursts	0.7	1.2	2.0	1.4	0.6
Total sessions with >9 infusions	1.5	1.9	2.2	1.5	-1.3
Short access day 1 total inactive lever presses	0.7	1.5	2.2	1.5	0.9
Short access day 10 total inactive lever presses	0.5	3.1	3.7	-1.6	1.9
Short access day 1 total infusions	0.4	0.8	1.6	1.2	-0.3
Short access day 10 total infusions	1.3	2.1	2.4	1.5	-1.4
Short access total infusions	1.1	1.6	2.4	1.6	-0.9
Short access day 1 locomotion	0.4	0.6	1.0	0.5	-1.0
Short access day 10 total locomotion	0.3	1.3	1.5	1.0	-1.2
Short access total locomotion	2.1	3.2	3.3	1.8	-1.8
One hour access (0.3 mA shock)	0.4	0.4	0.5	0.7	-0.6
Compulsive drug intake	0.7	1.0	1.7	-0.6	1.3
One hour access (shock baseline)	0.6	1.7	2.2	1.5	-1.1
Social response proportion	1.6	2.1	4.1	-0.0	2.0
Social responses	2.2	2.9	3.4	-1.6	1.8
Social time	0.1	0.2	0.3	-0.5	-0.2
Soleus weight	1.6	4.8	7.8	-2.8	1.3
Bone: stiffness	2.5	4.5	5.5	-1.9	2.3
Tibialis anterior weight	0.2	0.6	1.0	-0.3	1.0
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.3	0.0	0.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.4	-0.2
Time to tail flick, test, before self-admin	2.1	2.4	3.3	1.3	-1.8
Time to tail flick, test, after self-admin	0.8	0.9	1.2	0.7	1.1
Delta time to tail flick, vehicle, before/after SA	1.1	1.2	1.8	-1.3	-0.7
Delta time to tail flick, test, before/after SA	2.5	3.1	6.1	-0.4	2.5
Tibia length	0.4	1.2	1.7	-1.3	0.9
Ambulatory time before self-admin	0.6	2.0	2.2	1.3	-1.5
Ambulatory time after self-admin	2.2	3.6	4.0	1.8	-2.0
Bone: tissue strength	0.1	0.1	0.1	0.2	-0.4
Total heroin consumption	5.3	6.3	12.5	-3.5	0.2
Bone: trabecular number	2.6	4.9	6.3	-1.9	2.5
Bone: trabecular spacing	2.7	4.0	6.4	2.5	-1.2
Bone: trabecular thickness	8.9	12.3	17.1	-4.1	2.7
Bone: trabecular tissue density	1.2	2.1	4.1	2.0	-0.2
Water consumed over 24 hours	0.1	0.2	0.3	-0.5	0.3
Number of responses in last shaping day	0.6	0.7	0.9	0.7	-1.0